Dermatologie (Heidelberg, Germany)最新文献

{"title":"[Severe anaphylaxis following administration of omalizumab].","authors":"Franziska Keidel, Priscila Wölbing, Knut Schäkel","doi":"10.1007/s00105-025-05542-9","DOIUrl":"10.1007/s00105-025-05542-9","url":null,"abstract":"<p><p>A patient with chronic spontaneous urticaria (CSU) received treatment with the monoclonal antibody omalizumab, which resulted in significant clinical improvement but repeatedly triggered severe anaphylactic reactions. These occurred both after administration of the medication and during a prick test. The exact mechanisms behind the reactions are unclear; possible causes could include additives such as polysorbate 20 or specific antibodies. The case highlights the rare but serious risk of anaphylaxis with omalizumab and emphasizes the need for close monitoring and emergency preparedness.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"578-580"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Mycoses].","authors":"Valentina Laura Müller, Pietro Nenoff, Peter Mayser","doi":"10.1007/s00105-025-05559-0","DOIUrl":"https://doi.org/10.1007/s00105-025-05559-0","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":"76 9","pages":"521-522"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Trichophyton mentagrophytes ITS genotype VIII/Trichophyton indotineae in Germany-revisit after 5 years].","authors":"Silke Uhrlaß, Rüdiger Panzer, Daniela Koch, Hanna Mütze, Susanne Richter, Lena Müller, Michael Ardabili, Marko Averbeck, Claudia Baldauf, Janina Batel, Sophia Bender-Säbelkampf, Martin Braun, Elisabeth Bröse, Cornelia Deutsch, Eleni Fischer, Antje Ganser, Walter Geißdörfer, Philipp Grigorjan, Christina Hawlitschek, Oliver Hirschsteiner, Johanna Maria Hoffmann, Michael Hoffmann, Silke C Hofmann, Uta Hradetzky, Julia Huynh, Martin Jansen, Eva Kämmerer, Esther Klonowski, Lars Köhler, Constanze Krüger, Friederike Lange, Andreas Maronna, Isabell Marxsen, Christine Meder, Andreas Montag, Valentina Laura Müller, Georgios Nikolakis, Astrid Odon, Marie Rabe, Susanne Rausch, Lena Ressler, Linda Richter, Martin Schaller, Tim Schäfer, Tobias Sinnberg, Cassian Sitaru, Michael Sticherling, Shyam B Verma, Floras Voigt, Birgit Walker, Carolin Wamsler, Tino Wetzig, Pietro Nenoff","doi":"10.1007/s00105-025-05553-6","DOIUrl":"10.1007/s00105-025-05553-6","url":null,"abstract":"<p><p>Trichophyton (T.) mentagrophytes ITS genotype VIII/T. indotineae (TMVIII/TINDO) is a new, anthropophilic dermatophyte from the T. mentagrophytes/T. interdigitale complex that has gained increasing importance worldwide in recent years. This pathogen is characterized by frequent terbinafine resistance and a clinical picture of pronounced, inflammatory, and therapy-resistant dermatophytoses that predominantly affect the groin, trunk, extremities, and face. Between 2018 and the end of 2024, all TMVIII/TINDO cases detected in patients from Germany by culture and/or molecular biology were systematically recorded at the Leipzig-Mölbis laboratory. Identification and genotyping were performed by sequencing the internal transcribed spacer (ITS) region of the rDNA. In vitro resistance testing for terbinafine and itraconazole was performed using a breakpoint test. Additionally, the squalene epoxidase (SQLE) gene was sequenced to analyze resistance-associated point mutations. A total of 242 isolates from 196 patients were identified; some patients were consecutively detected repeatedly. The majority of affected patients had a migration background, particularly from South Asia (especially India) and Arab countries. Only a few infections were diagnosed in patients of German descent. As part of the diagnostic workup an in vitro susceptibility testing was performed using a breakpoint test, which demonstrated terbinafine resistance in 61.8% of the TMVIII/TINDO strains. Point mutations in the SQLE gene that correlated with resistance were found in a total of 161 of 188 strains. The most frequently detected mutation was Phe³⁹⁷Leu, which was associated with terbinafine resistance and clinical treatment failure with terbinafine in all cases. In addition, double mutations were detected in 26 strains. In vitro itraconazole resistance was observed in 11 of 186 tested isolates, corresponding to 5.9%. Itraconazole is currently the drug of choice for the systemic treatment of TMVIII/TINDO dermatophytoses. The recommended dosage is 100 mg twice daily for a period of 4-8 weeks, or up to 12 weeks if needed. Concurrent topical treatment with azoles, amorolfine, or ciclopirox is always recommended. In the event of itraconazole treatment failure, there are currently no standardized treatment recommendations. The off-label use of voriconazole has been reported in isolated cases, and there is also experimental experience with other active ingredients. The spread of TMVIII/TINDO in Germany and worldwide is particularly worrying in view of the dermatophyte's resistance to terbinafine and itraconazole.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"551-564"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Large intramuscular lipoma of the tensor fasciae latae muscle].","authors":"Zacharias Drosos, Felix Cromme, Almut Böer-Auer, Thomas Mentzel, Syrus Karsai","doi":"10.1007/s00105-025-05529-6","DOIUrl":"10.1007/s00105-025-05529-6","url":null,"abstract":"<p><p>We present the case of a woman with a large intramuscular lipoma of the tensor fasciae latae muscle. Histologically, the diagnosis was confirmed and differentiated from other entities by immunohistochemical staining. Our case underlines the importance of radiologic and histologic differentiation of common lipomas from atypical adipose tissue tumors.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"575-577"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Lupus erythematosus].","authors":"Patrick-Pascal Strunz, Marc Schmalzing, Matthias Goebeler, Astrid Schmieder","doi":"10.1007/s00105-025-05554-5","DOIUrl":"10.1007/s00105-025-05554-5","url":null,"abstract":"<p><p>Cutaneous lupus erythematosus (CLE) comprises a heterogeneous spectrum of autoimmune dermatoses. Four main forms are distinguished: acute (ACLE), subacute (SCLE), intermediate (ICLE), and chronic CLE (CCLE). Epidemiological studies show that the overall risk of developing systemic lupus erythematosus (SLE) is highest within the first 3 years following diagnosis of CLE. Therefore, patients with newly diagnosed CLE should be closely monitored for systemic symptoms, especially in the first few years following CLE diagnosis. Therapy of CLE includes both topical and systemic approaches. Treatment of SLE with organ and cutaneous manifestation should ideally be treated in close cooperation with an internal medicine rheumatologist. The overall therapeutic landscape of lupus erythematosus in increasingly moving toward personalized approaches.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"582-600"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Development of resistance in skin fungi : Molecular mechanisms, antifungal resistance assays, risk factors, and diagnostic regime-challenges for medical treatment].","authors":"Anke Burmester, Cornelia Wiegand","doi":"10.1007/s00105-025-05527-8","DOIUrl":"10.1007/s00105-025-05527-8","url":null,"abstract":"<p><p>The growing prevalence of resistant dermatophyte isolates, particularly from Trichophyton indotineae (synonym: T. mentagrophytes ITS genotype VIII) but also from T. rubrum may lead to increasing numbers of difficult-to-treat dermatomycoses. Terbinafine resistance in T. indotineae or T. rubrum is caused by point mutations that alter specific positions in the Erg1 gene encoding squalene epoxidase, thereby, preventing effective binding of terbinafine to the enzyme. In T. indotineae, two different forms of genomic amplification of Erg11B that lead to azole resistance have been identified. Like Erg11A, Erg11B encodes a form of sterol-14-α-demethylase, whose enzymatic activity is inhibited by azole binding. In T. indotineae as well as in T. rubrum, point mutations in Erg11B have been identified that result in altered amino acid sequences and prevent binding of specific classes of azoles. Another resistance mechanism involves increased expression of transporter proteins responsible for drug efflux. The combination of these various mechanisms presents a major challenge for diagnostics and requires adaptation of both the diagnostic approach and the subsequent therapeutic strategies.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"523-532"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Trichophyton indotineae-a master in treatment resistance].","authors":"Valentina Laura Müller, Pietro Nenoff, Silke Uhrlaß, Alexander Kreuter","doi":"10.1007/s00105-025-05543-8","DOIUrl":"10.1007/s00105-025-05543-8","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"574"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OMW: Von der Adjuvanz zur Neoadjuvanz: Neue Therapiestrategien beim Melanom ab dem Stadium IIIB.","authors":"Miriam Mengoni, Evelyn Gaffal, Andreas Dominik Braun","doi":"10.1007/s00105-025-05560-7","DOIUrl":"10.1007/s00105-025-05560-7","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"581"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Relevant aspects of Candida species in dermatology : An overview].","authors":"Valentina Laura Müller, Alexander Kreuter, Silke Uhrlaß, Pietro Nenoff","doi":"10.1007/s00105-025-05538-5","DOIUrl":"10.1007/s00105-025-05538-5","url":null,"abstract":"<p><p>Candida species are opportunistic yeasts that form part of the normal human microbiota. Under certain conditions, such as immunosuppression, alterations in the microbiota, or disruption of the skin barrier, these commensals may become pathogenic and lead to clinically relevant infection. Candida (C.) albicans plays a central role in skin and mucosal infections, while other species, such as Nakaseomyces (N.) glabratus (formerly known as Candida glabratus) and C. auris, are increasingly gaining clinical significance. The most common Candida infections affect the skin and mucosal membranes; however, under predisposing factors, the pathogen can enter the bloodstream, leading to septicemia with organ involvement. In this context, multidrug-resistant pathogens, particularly C. auris, pose an escalating threat to public health. Diagnosis of Candida species is generally performed using conventional microbiological techniques, including cultures and microscopy, as well as advanced molecular methods such as polymerase chain reaction (PCR) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Given the rising rates of resistance and the associated therapeutic challenges, accurate species identification and resistance profiling prior to antifungal treatment are critical. Preventive measures, especially for high-risk populations, are crucial to reduce the incidence of Candida infections. While many superficial Candida infections can be managed with hygiene practices and topical antifungal treatments, invasive candidiasis necessitates close collaboration between microbiology, pharmacology, and infectious disease specialists to ensure optimal patient care.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"544-550"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Artificial intelligence in total body photography, digital dermoscopy and high-resolution dermoscopy].","authors":"S Hobelsberger, A-T Seitz","doi":"10.1007/s00105-025-05570-5","DOIUrl":"https://doi.org/10.1007/s00105-025-05570-5","url":null,"abstract":"<p><strong>Background: </strong>The incidence of malignant melanoma has increased exponentially in recent decades. The combination of total body photography (TBP) and digital dermoscopy (DD) improved the early detection of melanoma in previous studies. Furthermore, the use of artificial intelligence (AI) can improve the diagnostic accuracy of dermatologists.</p><p><strong>Objectives: </strong>In the present work, the applications of AI in TBP, DD, and high-resolution dermoscopy in clinical practice are evaluated.</p><p><strong>Materials and methods: </strong>A literature review was conducted of previous studies on the use of TBP, DD, and high-resolution dermoscopy and the integration of AI in these devices for the early detection of melanoma.</p><p><strong>Results and conclusion: </strong>The use of AI can improve the diagnostic accuracy of TBP, DD, and high-resolution dermoscopy. As most of the studies to date have been conducted in an artificial setting, more studies are needed to evaluate the potential use of AI in the clinical setting. In addition, staff must be trained and informed about the legal framework regarding the use of AI in everyday clinical practice.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}