Current research in physiology最新文献

{"title":"Positive effects of single-nanosized oxygen nanobubble water on exercise tolerance: A randomized crossover trial","authors":"Yuki Muramoto ,&nbsp;Noriyuki Ishida ,&nbsp;Emi Minaguchi ,&nbsp;Kazuhisa Sugai ,&nbsp;Kyohei Daigo ,&nbsp;Yuji Iwasawa ,&nbsp;Genki Ichihara ,&nbsp;Kengo Nagashima ,&nbsp;Yasunori Sato ,&nbsp;Kazuki Sato ,&nbsp;Yoshinori Katsumata","doi":"10.1016/j.crphys.2025.100159","DOIUrl":"10.1016/j.crphys.2025.100159","url":null,"abstract":"<div><div>The effect of single-nanosized oxygen nanobubble water (NBO₂W), an oxygen-enriched beverage, on exercise performance remains unclear. This double-blind, randomized, placebo-controlled crossover trial investigated whether NBO₂W intake influences lactate threshold (LT), a key indicator of aerobic exercise performance. The participants (n = 20; age, 47.4 ± 5.0 years; female, 12) consumed either NBO₂W or placebo water (PW) immediately followed by an incremental exercise test on an ergometer for symptom-limited exhaustion. During the test, the heart rate, respiratory gas analysis (VO₂ and VCO₂), tissue oxygen index (TOI), and blood lactate level were continuously monitored. The first administered beverage was randomly selected, with both participants and investigators blinded to the beverages. A washout period of minimum seven days was implemented between the two tests. The mean peak VO₂ was 26.13 ± 5.05 mL/min/kg. Eighteen (90 %) participants exercised less than four times per week, indicating limited exercise habits. The average washout period was 9.7 ± 5.0 days. The work rate (WR) at LT was significantly higher after NBO₂W intake than after PW intake (mean difference = 3.33 W, p = 0.03). The WR was not significantly different at peak VO₂ or at the onset of blood lactate accumulation. Furthermore, NBO₂W intake significantly increased the lactate levels 5 min post-exercise (mean difference = 0.88, p = 0.01) and decreased the TOI (mean difference = −3.8, p = 0.01). Short-term NBO₂W consumption in three doses, including that on the day before exercise, did not affect the peak exercise capacity, but improved the WR at LT.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100159"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144781014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using digital escape rooms to enhance data analysis skills and student experience in a higher education human physiology module","authors":"Nicola Morgan,&nbsp;Marriam Yaqoob,&nbsp;Matthew Allan Jones","doi":"10.1016/j.crphys.2025.100165","DOIUrl":"10.1016/j.crphys.2025.100165","url":null,"abstract":"<div><div>Active and gamified teaching methods have garnered significant interest, with an increased demand for higher education institutions to enhance student engagement. One popular example of active learning is the escape room. Escape rooms are playful tools reported to increase students’ key transferable skills, which are valuable for students to boost their employability. In recent years, a transition to “digital” computerised escape rooms has allowed participants similar experiences using significantly fewer resources compared to in-person modalities. In physiology, the ability to analyse and interpret data is vital and an intended learning outcome of physiology modules/units. However, many students possess limited experience or exhibit anxiety when conducting data analysis, which leaves them unprepared to do this within a laboratory setting or employment. Therefore, this project aimed to design and develop a digital escape room to allow students to playfully build their analytical skills and assess its impact on student experience and knowledge acquisition.</div><div>The digital escape room was created using the University of Salford's universal digital escape room platform “UoScape”. Students' perceived data analysis skills and experience upon completion were evaluated using pedagogical surveys comprising either open-answer questions or a 5-point Likert scale.</div><div>A total of 104 second-year undergraduate students completed the evaluation survey. Most students reported positive benefits to their knowledge of physiological data analysis (74.0 %), overall experience (67.3 %), experience of gamified learning (74.0 %) and that it would enhance their overall degree value (68.3 %). The majority of students stated digital escape rooms would support their education (71.2 %) and upcoming assessments (76.0 %). Individual puzzle analysis identified those with mathematical elements as more challenging than image analysis-based puzzles (73.3 % Vs 51.8 %, <em>P</em> = 0.0006). Interestingly, a positive correlation was observed between challenge and enjoyment within mathematics puzzles (R = 0.308, <em>P</em> = 0.004). Stratification based on socioeconomic factors revealed minimal impact on pedagogical measures, with only self-perceived knowledge acquisition being significantly higher in low-access populations (<em>P</em> = 0.046).</div><div>These data show the equitable pedagogical benefits of digital escape rooms, which enhance students’ knowledge of handling physiological data, student experience, and degree value. This highlights the benefits of active gamified teaching methods for physiological concepts within higher education.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100165"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic effects of late-onset estradiol replacement in high-fat-fed ovariectomized mice","authors":"Alessandra Gonçalves da Cruz,&nbsp;Jessica Denielle Matos dos Santos,&nbsp;Ester dos Santos Alves,&nbsp;Anne Raissa Melo dos Santos,&nbsp;Bruna Fantini Trinca,&nbsp;Felipe Nunes de Camargo,&nbsp;Guilherme Fancio Bovolin,&nbsp;João Paulo Camporez","doi":"10.1016/j.crphys.2025.100144","DOIUrl":"10.1016/j.crphys.2025.100144","url":null,"abstract":"<div><h3>Background</h3><div>Decreased estrogen levels in postmenopausal women negatively impact metabolic health. It is known that estradiol (E2) replacement can reverse this condition. However, there is no consensus on whether the effects mediated by E2 depend on the starting time of E2 replacement after menopause. We aimed to investigate the effects of different onset E2 treatments on glucose tolerance and metabolic parameters in high-fat-fed ovariectomized mice.</div></div><div><h3>Material and methods</h3><div>Eight-week-old female C57BL/6J mice were divided into three groups: SHAM, OVX, and E2, to evaluate three different time points of E2 replacement after ovariectomy: early (after 4 weeks), intermediate (after 12 weeks), and late replacement (after 20 weeks). E2 groups received treatment through subcutaneous pellets.</div></div><div><h3>Results</h3><div>E2 replacement improved the parameters analyzed independently of the time since ovariectomy, reducing body weight gain and fat mass, as well as increasing the percentage of lean mass. Glucose intolerance, fasting insulin, HOMA-IR, and cholesterol levels were also reduced after treatment with E2. In the liver, there was a decrease in triacylglycerol (TAG) deposition, with no difference in the expression of SREBP1 and ERα proteins. In the muscle, there was a decrease in TAG deposition. In periuterine adipose tissue, there was an increase in the expression of SREBP1, FASN, and SCD, with no difference in the expression of ERα.</div></div><div><h3>Conclusions</h3><div>Our findings reinforce the critical role of E2 in regulating both glucose and lipid metabolism and indicate that E2 action on metabolic health was not dependent on time since ovariectomy for the parameters analyzed.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100144"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderate chronic aortic constriction induces modest, sex-specific effects on rat hearts and skeletal muscle","authors":"William S. Evans ,&nbsp;Yuan Liu ,&nbsp;Maria Clara Canellas Da Silva ,&nbsp;Harry Zichen Li ,&nbsp;Steven J. Prior ,&nbsp;Sarah Kuzmiak-Glancy","doi":"10.1016/j.crphys.2025.100153","DOIUrl":"10.1016/j.crphys.2025.100153","url":null,"abstract":"<div><div>Heart failure with preserved ejection fraction (HFpEF) accounts for ∼50 % of heart failure diagnoses, occurs in older individuals, is more prevalent in females than males, and includes hypertension as contributing factor. We sought to determine whether a long-term, moderate, transverse aortic constriction in male and female rats induces ventricular hypertrophy and preserved ejection fraction, changes in skeletal muscle mass and strength, and sex-specific differences in these outcomes, mimicking HFpEF. Transverse aortic constriction (TAC) surgery was performed on male and female rats at 4 weeks of age, and rats were sacrificed 40 weeks after surgery, following echocardiography and grip strength measures. Male TAC rats demonstrated a 12 % greater heart mass and 17 % higher heart to body mass ratio than Sham rats; however, these parameters did not differ between female TAC and Sham rats. TAC rats demonstrated a preserved ejection fraction, and TAC had no effect on skeletal muscle size or strength. In summary, male rats were more susceptible to TAC-induced pressure-overload hypertrophy than female rats, and this moderate constriction resulted in preserved ejection fraction despite a long time course. Collectively, these investigations reveal, in the absence of comorbidities, pressure overload produces modest, sex-specific effects in the myocardium and skeletal muscle.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100153"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of the Quercetin on experimental cuprizone-induced multiple sclerosis in male C57BL/6 mice","authors":"Samin Ghasemi ,&nbsp;Shahin Hassanpour ,&nbsp;Razieh Hosseini","doi":"10.1016/j.crphys.2025.100146","DOIUrl":"10.1016/j.crphys.2025.100146","url":null,"abstract":"<div><div>This study aimed to determine protective effect of the Quercetin on experimental cuprizone-induced (CPZ) multiple sclerosis (MS) in Male C57BL/6 mice. Forty male C57BL/6 mice were allocated into 4 experimental groups. Control group received the standard diet. In group 2, mice received a diet containing 0.2 % (w/w) CPZ mixed with ground chow for a duration of 4 weeks (Zhu et al., 2021). In group 3, mice received Quercetin (150 mg/kg) orally every day for 4 weeks. In group 4, mice received a diet with 0.2 % CPZ and Quercetin (150 mg/kg) orally for 4 weeks. After incidence of the sign of the MS reflexive motor behavior and serum antioxidant levels were assessed. Based on the findings, administration of the CPZ significantly decreased ambulation score, number of crosses using OFT (open field test), stay on rotarod, hindlimb foot angle, front- and hindlimb suspension and grip strength (P &lt; 0.05). Quercetin significantly increased ambulation score, number of cross using, stay on rotarod, hindlimb foot angle, front- and hindlimb suspension and grip strength (P &lt; 0.05). Administration of the CPZ significantly increased serum malondialdehyde (MDA), tumor necrosis factor (TNF-α) and interleukin-1 beta (IL-1β) While decreased superoxide dismutase (SOD), glutathione peroxidase (GPX) and total antioxidant status (TAS) levels (P &lt; 0.05). Quercetin significantly decreased serum MDA, TNF-α and IL-1β while increased SOD, GPX and TAS levels (P &lt; 0.05). These results suggested, Quercetin has protective effect against CPZ-induced MS in mice.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100146"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Academic writing and critical appraisal in physiology education: discerning the benefits of using large language models as knowledge receivers or knowledge providers","authors":"Matthew Hardy","doi":"10.1016/j.crphys.2025.100156","DOIUrl":"10.1016/j.crphys.2025.100156","url":null,"abstract":"","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100156"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing laboratory education through collaborative online international learning: A case study between USA and UK students","authors":"Matthew Allan Jones ,&nbsp;Pika Miklavc ,&nbsp;MaryAnne Stewart","doi":"10.1016/j.crphys.2025.100141","DOIUrl":"10.1016/j.crphys.2025.100141","url":null,"abstract":"<div><div>Collaborative Online International Learning (COIL) has emerged in recent years as an effective and viable alternative to increase the international opportunities within taught curricula. Through recent innovations in online collaboration tools, and elevated demand for international opportunities, there has been a recent increase in the development of COIL opportunities globally across a range of health aligned disciplines. This style of learning has been described as positively contributing to the internationalisation of students and enhancement of their transferable skills. However, there have been no reported COIL opportunities described in the fields of laboratory medicine and biomedicine, likely due to the large practical elements associated with the subjects. This study therefore aims to develop a COIL opportunity that incorporates practical laboratory elements and evaluate the efficacy of this teaching and learning approach.</div><div>A laboratory-based COIL was developed and delivered across two days. Day one was composed of synchronous livestreamed laboratory demonstrations and practical activities, with day two focused on the completion of a time-dependent team-based task. The pedagogical impact of this laboratory-based COIL was evaluated through 1) pre and post surveys and 2) an overall survey utilising Likert scales.</div><div>The laboratory-based COIL was well received by students (n = 34) with the majority enjoying (94.1 %) and learnt a lot (94.1 %) by participating in the session. It also produced highly positive benefits to student confidence (97.1 %), teamworking (100 %), and communication (97.1 %). Pre (n = 46) and Post-analysis (n = 35) revealed significant enhancement of students international education knowledge, international medical practice knowledge, cultural intelligence, social initiative, emotional stability, and work-based flexibility (<em>P</em> &lt; 0.05). Further analysis based on participants international institution revealed significant differences in responses between the two participating cohorts, namely questions relating to cultural intelligence and their confidence of working with cultures unfamiliar to themselves.</div><div>We are the first to report that implementation of laboratory-based COIL opportunities have significant potential in enhancing students' international, cultural and transferable competencies within laboratory and health education. These findings suggest that practical-based COILs are effective methods for preparing students to thrive in a globalized healthcare environment, making a strong case for its continued use and expansion in educational programmes.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100141"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No sex differences in fatigability or neuromuscular responses during one set of maximal intended velocity muscle actions to failure at 30 % one-repetition maximum","authors":"Tyler J. Neltner ,&nbsp;Robert W. Smith ,&nbsp;Jocelyn E. Arnett ,&nbsp;Dolores G. Ortega ,&nbsp;Richard J. Schmidt ,&nbsp;Dona McCanlies ,&nbsp;Terry J. Housh","doi":"10.1016/j.crphys.2025.100149","DOIUrl":"10.1016/j.crphys.2025.100149","url":null,"abstract":"<div><div>Traditionally, research using dynamic constant external resistance (DCER) training has focused on self-selected velocities. This study aimed to examine sex differences in fatigability and neuromuscular responses during maximal intended velocity, DCER forearm flexion muscle actions to failure. Fourteen men (mean ± SD; age: 22.9 ± 2.0 yrs) and 13 women (age: 22.9 ± 2.6 yrs) completed one set of forearm flexion muscle actions to failure performing the concentric phase of the repetition at maximal intended velocity (as fast as possible). Electromyographic (EMG) and mechanomyographic (MMG) signals were recorded from the biceps brachii. The results indicated that men were significantly stronger and more powerful than women, however, there were no sex differences in the number of repetitions to failure (70 ± 18) or reductions in peak force (31 ± 8 %), peak velocity (57 ± 18 %), or peak power (64 ± 17 %). Additionally, there were no sex differences in the neuromuscular responses, which included increases in EMG amplitude (AMP), decreases in EMG mean power frequency (MPF), and no changes in MMG AMP or MPF. The increase in EMG AMP and decrease in EMG MPF, combined with no changes in MMG AMP or MPF, suggested that the decreases in performance were due to excitation contraction coupling failure, rather than a reduction in central drive. Thus, despite the low relative load, the maximal intended velocity muscle actions resulted in similar impairments of contractile function for the men and women that diminished sex differences in fatigability.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100149"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the hypoglycemic effect of Cyanthillium cinereum (L.) H. Rob. and its dual impact on uterine contraction in gestational diabetic rats","authors":"Sasitorn Kerdsuknirund ,&nbsp;Arreeya Kosinan ,&nbsp;Panida Khunkaewla ,&nbsp;Pakanit Kupittayanant ,&nbsp;Pattama Tongdee ,&nbsp;Porntip Nimkuntod ,&nbsp;Susan Wray ,&nbsp;Sajeera Kupittayanant","doi":"10.1016/j.crphys.2025.100139","DOIUrl":"10.1016/j.crphys.2025.100139","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the effects of <em>Cyanthillium cinereum</em> (L.) H. Rob. ethanolic extract (CCE) on gestational diabetes mellitus (GDM) in rats using biochemical, histological, and uterine contractility studies.</div></div><div><h3>Methods</h3><div>Diabetes was induced in pregnant rats using streptozotocin (60 mg/kg). CCE was administered orally at low (50 mg/kg BW) and high (500 mg/kg BW) doses from gestation day 7 to day 21. Maternal evaluations included body weight, gravid uterine weight, and biochemical assays for serum glucose, insulin, lipids, and liver enzymes. Fetal outcomes included fetal size. Histological analyses of maternal pancreatic and uterine tissues and uterine contractility studies using <em>ex vivo</em> muscle strip experiments were also performed.</div></div><div><h3>Results</h3><div>CCE and metformin (MET) significantly reduced elevated blood glucose levels and improved the Islets of Langerhans area compared to the GDM group (<em>P</em> &lt; 0.05). Both treatments showed a trend toward increased insulin levels (<em>P</em> &gt; 0.05) and significantly reduced lipids, AST, and ALP levels (<em>P</em> &lt; 0.05). High-dose CCE and MET increased gravid uterine weight and fetal size (<em>P</em> &lt; 0.05) while showing a trend toward reducing placental weight and index (<em>P</em> &gt; 0.05). Histological analysis revealed increased fiber area and decreased interstitial space in uterine sections (<em>P</em> &lt; 0.05). <em>Ex vivo</em>, CCE enhanced spontaneous and oxytocin-induced contractions (<em>P</em> &lt; 0.05), while MET had no effect.</div></div><div><h3>Conclusion</h3><div>CCE reduces elevated glucose levels and exhibits hypolipidemic and hepatoprotective effects, improving maternal and fetal outcomes in GDM. Its uterine contractility effects suggest potential as a complementary therapy to MET for GDM management.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100139"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143210956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in the association between albuminuria and vascular health in individuals living with chronic kidney disease","authors":"Badal S.B. Pattar ,&nbsp;Sofia B. Ahmed ,&nbsp;Jessalyn K. Holodinsky ,&nbsp;Nicole Larsen ,&nbsp;Sakshi Kharbanda ,&nbsp;Sarah Rabi ,&nbsp;Victoria Riehl-Tonn ,&nbsp;Darlene Y. Sola ,&nbsp;Sarah Blayney ,&nbsp;Sandra M. Dumanski","doi":"10.1016/j.crphys.2025.100145","DOIUrl":"10.1016/j.crphys.2025.100145","url":null,"abstract":"<div><div>Cardiovascular disease is the leading cause of death in chronic kidney disease (CKD). Albuminuria, a marker of CKD severity, is independently associated with cardiovascular disease, however limited studies explore the impact of sex. We aimed to explore sex differences in the association between albuminuria and vascular health in individuals living with CKD. Albuminuria was quantified through urine albumin-to-creatinine ratio (uACR) and measures of vascular health included Aortic Augmentation Index (AIx), Pulse Wave Velocity (PWV) and Mean Arterial Pressure (MAP). Multivariable linear regression analyses estimated the association between uACR and each outcome, and sex was assessed as an effect modifier. Adults living with CKD were recruited from nephrology clinics in Calgary, Canada and 66 participants (39 female, 27 male) were included in this study. A higher eGFR (89[56] versus 58[50] ml/min/1.73m2) and lower uACR (32[405] versus 386[933] mg/g) were observed in females. Sex modified the relationship between uACR and AIx; with a positive association in females (<span><math><mrow><mi>β</mi></mrow></math></span> = 0.02; p &lt; 0.01), and no relationship in males (<span><math><mrow><mi>β</mi></mrow></math></span> = -0.004; p = 0.16). Positive relationships between uACR and both PWV and MAP were observed, though sex did not modify either relationship. Further research to elucidate the mechanisms underpinning these sex differences are necessary to optimize and personalize cardiovascular risk reduction strategies in CKD.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100145"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}