Current research in physiology最新文献

{"title":"Assessment of the hypoglycemic effect of Cyanthillium cinereum (L.) H. Rob. and its dual impact on uterine contraction in gestational diabetic rats","authors":"Sasitorn Kerdsuknirund ,&nbsp;Arreeya Kosinan ,&nbsp;Panida Khunkaewla ,&nbsp;Pakanit Kupittayanant ,&nbsp;Pattama Tongdee ,&nbsp;Porntip Nimkuntod ,&nbsp;Susan Wray ,&nbsp;Sajeera Kupittayanant","doi":"10.1016/j.crphys.2025.100139","DOIUrl":"10.1016/j.crphys.2025.100139","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the effects of <em>Cyanthillium cinereum</em> (L.) H. Rob. ethanolic extract (CCE) on gestational diabetes mellitus (GDM) in rats using biochemical, histological, and uterine contractility studies.</div></div><div><h3>Methods</h3><div>Diabetes was induced in pregnant rats using streptozotocin (60 mg/kg). CCE was administered orally at low (50 mg/kg BW) and high (500 mg/kg BW) doses from gestation day 7 to day 21. Maternal evaluations included body weight, gravid uterine weight, and biochemical assays for serum glucose, insulin, lipids, and liver enzymes. Fetal outcomes included fetal size. Histological analyses of maternal pancreatic and uterine tissues and uterine contractility studies using <em>ex vivo</em> muscle strip experiments were also performed.</div></div><div><h3>Results</h3><div>CCE and metformin (MET) significantly reduced elevated blood glucose levels and improved the Islets of Langerhans area compared to the GDM group (<em>P</em> &lt; 0.05). Both treatments showed a trend toward increased insulin levels (<em>P</em> &gt; 0.05) and significantly reduced lipids, AST, and ALP levels (<em>P</em> &lt; 0.05). High-dose CCE and MET increased gravid uterine weight and fetal size (<em>P</em> &lt; 0.05) while showing a trend toward reducing placental weight and index (<em>P</em> &gt; 0.05). Histological analysis revealed increased fiber area and decreased interstitial space in uterine sections (<em>P</em> &lt; 0.05). <em>Ex vivo</em>, CCE enhanced spontaneous and oxytocin-induced contractions (<em>P</em> &lt; 0.05), while MET had no effect.</div></div><div><h3>Conclusion</h3><div>CCE reduces elevated glucose levels and exhibits hypolipidemic and hepatoprotective effects, improving maternal and fetal outcomes in GDM. Its uterine contractility effects suggest potential as a complementary therapy to MET for GDM management.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100139"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143210956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in the association between albuminuria and vascular health in individuals living with chronic kidney disease","authors":"Badal S.B. Pattar ,&nbsp;Sofia B. Ahmed ,&nbsp;Jessalyn K. Holodinsky ,&nbsp;Nicole Larsen ,&nbsp;Sakshi Kharbanda ,&nbsp;Sarah Rabi ,&nbsp;Victoria Riehl-Tonn ,&nbsp;Darlene Y. Sola ,&nbsp;Sarah Blayney ,&nbsp;Sandra M. Dumanski","doi":"10.1016/j.crphys.2025.100145","DOIUrl":"10.1016/j.crphys.2025.100145","url":null,"abstract":"<div><div>Cardiovascular disease is the leading cause of death in chronic kidney disease (CKD). Albuminuria, a marker of CKD severity, is independently associated with cardiovascular disease, however limited studies explore the impact of sex. We aimed to explore sex differences in the association between albuminuria and vascular health in individuals living with CKD. Albuminuria was quantified through urine albumin-to-creatinine ratio (uACR) and measures of vascular health included Aortic Augmentation Index (AIx), Pulse Wave Velocity (PWV) and Mean Arterial Pressure (MAP). Multivariable linear regression analyses estimated the association between uACR and each outcome, and sex was assessed as an effect modifier. Adults living with CKD were recruited from nephrology clinics in Calgary, Canada and 66 participants (39 female, 27 male) were included in this study. A higher eGFR (89[56] versus 58[50] ml/min/1.73m2) and lower uACR (32[405] versus 386[933] mg/g) were observed in females. Sex modified the relationship between uACR and AIx; with a positive association in females (<span><math><mrow><mi>β</mi></mrow></math></span> = 0.02; p &lt; 0.01), and no relationship in males (<span><math><mrow><mi>β</mi></mrow></math></span> = -0.004; p = 0.16). Positive relationships between uACR and both PWV and MAP were observed, though sex did not modify either relationship. Further research to elucidate the mechanisms underpinning these sex differences are necessary to optimize and personalize cardiovascular risk reduction strategies in CKD.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100145"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High carbohydrate diet programs metabolic enzyme gene expression modification in F2 generation wistar rat males","authors":"Joseph Chimezie ,&nbsp;Worship Odosa Agbonifo ,&nbsp;Hope Oluwabukola Francis ,&nbsp;Mercy Oluwaseun Awoleye ,&nbsp;Temitope Gabriel Adedeji","doi":"10.1016/j.crphys.2025.100154","DOIUrl":"10.1016/j.crphys.2025.100154","url":null,"abstract":"<div><div>Diets high in carbohydrates (HCD) negatively impact transgenerational metabolic health and phenotype, factors directly influenced by gene expression. This study investigates the effects of HCD feeding on gene expression of key enzymes of important metabolic pathways in the Parent (F0), first (F1) and second (F2) filial generations. Each generation consisted of a control and HCD group of male and female counterparts in the F0 and F1 generations. Female rat cohorts (F0) fed a control or high-carbohydrate diet were mated at pro-oestrous period with males fed with similar diets at a ratio of 1:1 overnight. The offspring of the F1 generation exposed to the same diet were mated (1:1) to produce the F2 generation fed on a control diet. Male animals in each generation were analysed for metabolic changes, gene expression, and phenotypic outcomes. The results indicate that HCD caused significant increases (P &lt; 0.05) in body weight in both the F1 and F2 generations, fasting blood glucose in the F2 generation, as well as serum insulin and HOMA-IR in the F1 and F2 generations. The F0 and F1 HCD-fed rats demonstrated a significant increase (P &lt; 0.05) in the expression of genes involved in glycolysis and glycogen synthesis, along with a significant decrease (P &lt; 0.05) in the expression of genes for gluconeogenic enzymes. Additionally, there was an increase (P &lt; 0.05) in the expression of genes associated with fatty acid biosynthesis and a decrease (P &lt; 0.05) in β-oxidation gene expression, a pattern similarly observed in control-fed F2 male rats. These findings suggest that a parental diet high in carbohydrates can induce modifications in the gene expression of metabolic rate-limiting enzymes in F2 offspring, regardless of their diet. However, this study did not assess the epigenetic modifications potentially responsible for the observed transgenerational effects. Future research could investigate epigenetic changes such as DNA methylation and histone modifications, and also assess these effects in female animals.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100154"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acidosis enhances contribution of Ca2+-activated chloride channels to vascular tone regulation in early postnatal period","authors":"Anastasia A. Shvetsova ,&nbsp;Margarita A. Khlystova ,&nbsp;Valentina S. Shateeva ,&nbsp;Sofia D. Simonenko ,&nbsp;Anna A. Borzykh ,&nbsp;Denis V. Abramochkin ,&nbsp;Dina K. Gaynullina","doi":"10.1016/j.crphys.2025.100143","DOIUrl":"10.1016/j.crphys.2025.100143","url":null,"abstract":"<div><h3>Introduction</h3><div>Acidosis often occurs during clinical complications in newborns and can lead to changes in the mechanisms of arterial tone regulation. However, it is unknown how acidosis affects the activity of Ca²⁺-activated chloride channels (CaCC) in arteries during early ontogenesis. We hypothesized that their activity may increase during acidosis.</div></div><div><h3>Methods</h3><div>We studied isometric contractions of saphenous arteries isolated from adult and 10-13-day-old rats. Intracellular pH was measured using a fluorescent indicator BCECF-AM simultaneously with recording the contractile activity of the arterial preparation in isometric mode.</div></div><div><h3>Results</h3><div>Metabolic acidosis with pH = 6.8 caused a significant decrease in the arterial contractile responses of adult and 10-13-day-old rats. The functional contribution of CaCC was absent in the adult rat arteries both at pH = 7.4 and pH = 6.8. However, in 10-13-day-old rat pups, the functional contribution of CaCC was higher at pH = 6.8 compared to pH = 7.4.</div></div><div><h3>Conclusion</h3><div>Acidosis augments the functional role of CaCC in arteries during early postnatal ontogenesis, but not in adulthood.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100143"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1H MRS-based metabolite changes at ventral respiratory control centers of the medulla oblongata following administration of morphine in wild-type and GIRK2 mutant mice","authors":"Ozra Dehkordi ,&nbsp;Stephen Lin ,&nbsp;Safia Mohamud ,&nbsp;Richard M. Millis ,&nbsp;Paul C. Wang","doi":"10.1016/j.crphys.2025.100147","DOIUrl":"10.1016/j.crphys.2025.100147","url":null,"abstract":"<div><div>Respiratory depression is the leading cause of death in opioid overdose and is closely associated with the development of tolerance following repeated morphine use. However, the neurochemical adaptations in brainstem regions that regulate breathing, particularly under chronic opioid exposure, remain poorly understood. G-protein-gated inwardly rectifying potassium (GIRK) channels, especially the GIRK2 subunit, are expressed in rhythm-generating neurons of the pre-Bötzinger complex and have been implicated in opioid-induced respiratory depression. Nonetheless, their specific role in morphine-induced neurochemical changes is not yet fully defined. In this study, <em>in vivo</em> proton magnetic resonance spectroscopy (¹H MRS) was used in mice to assess morphine-induced metabolite changes in ventral brainstem regions encompassing the pre-Bötzinger complex. Wild-type mice were compared with GIRK2 heterozygous (GIRK2⁺/⁻) mutants. Baseline levels of several metabolites including glutamate (Glu), myo-inositol (Ins), N-acetylaspartate plus N-acetylaspartylglutamate (NAA + NAAG), and glutamate plus glutamine (Glu + Gln) differed significantly between GIRK2⁺/⁻ and wild-type mice. Despite these baseline differences, many of morphine's effects on metabolite levels were similar in the wild-type and GIRK2⁺/⁻ mice. Morphine increased phosphocreatine (PCr) in both genotypes, while total creatine (Cr + PCr) decreased only in the wild-type mice. Glutamine levels increased significantly in both groups. Notably, NAA decreased in wild-type but increased in GIRK2⁺/⁻ mice, whereas NAA + NAAG decreased in both. These findings demonstrate that chronic morphine exposure induces substantial neurochemical changes in brainstem respiratory centers. Although the GIRK2⁺/ ^- mutation altered some of the metabolite responses, it does not fully block morphine's effects, highlighting the complexity of opioid-induced adaptations in the respiratory control networks.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100147"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The story so far………- current opinion in the use and applications of interactive storytelling in physiology and clinical education","authors":"Bagley L. ,&nbsp;Wilson J. ,&nbsp;Kime A.","doi":"10.1016/j.crphys.2025.100142","DOIUrl":"10.1016/j.crphys.2025.100142","url":null,"abstract":"<div><div>Physiology and clinical practice are subjects of study which demand integration of multiple sources of systems working knowledge and information on the performance of those systems to come to meaningful conclusions. This is made more complex by the interpretation and actions as a result of this conclusion having direct impact on the sum of the component systems, the human, thereby integrating significant social and psychological considerations into an already complex situation.</div><div>As higher education educators, it is a significant challenge to provide our learners with training and most importantly, practice, in these knowledge, skills and behaviours in the classroom. There has been a significant interest in recent years in providing active learning opportunities which allow learners to apply subject knowledge to multi-faceted, immersive, continuously evolving stories which reflect a graduate's professional aspirations. This review highlights practices from the literature of storytelling education which the higher education educator can utilise in promoting “meaning making” in the classroom. Here, the case for interactive storytelling in physiology and clinical education is argued, as well as presenting commonly utilised techniques and practices with which educators can embed storytelling into their pedagogy as well as highlighting future directions in this field.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100142"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular endothelial cells display organ-specific responses to extracellular matrix stiffness","authors":"Rana Haidari ,&nbsp;Wesley J. Fowler ,&nbsp;Stephen D. Robinson ,&nbsp;Robert T. Johnson ,&nbsp;Derek T. Warren","doi":"10.1016/j.crphys.2025.100140","DOIUrl":"10.1016/j.crphys.2025.100140","url":null,"abstract":"<div><div>The extracellular matrix was originally thought of as simply a cellular scaffold but is now considered a key regulator of cell function and phenotype from which cells can derive biochemical and mechanical stimuli. Age-associated changes in matrix composition drive increases in matrix stiffness. Enhanced matrix stiffness promotes the progression of numerous diseases including cardiovascular disease, musculoskeletal disease, fibrosis, and cancer. Macrovascular endothelial cells undergo endothelial dysfunction in response to enhanced matrix stiffness. However, endothelial cells are highly heterogeneous, adopting structural and gene expression profiles specific to their organ of origin. Endothelial cells isolated from different vessels (i.e. arteries, veins or capillaries) respond differently to changes in substrate stiffness. It is unknown whether microvascular endothelial cells isolated from different organs also display organ-specific responses to substrate stiffness. In this study, we compare the response of microvascular endothelial cells isolated from both the mouse lung and mammary gland to a range of physiologically relevant substrate stiffnesses. We find that endothelial origin influences microvascular endothelial cell response to substrate stiffness in terms of both proliferation and migration speed. In lung-derived endothelial cells, proliferation is bimodal, where both physiologically soft and stiff substrates drive enhanced proliferation. Conversely, in mammary gland-derived endothelial cells, proliferation increases as substrate stiffness increases. Substrate stiffness also promotes enhanced endothelial migration. Enhanced stiffness drove greater increases in migration speed in mammary gland-derived than lung-derived endothelial cells. However, stiffness-induced changes in microvascular endothelial cell morphology were consistent between both cell lines, with substrate stiffness driving an increase in endothelial volume. Our research demonstrates the importance of considering endothelial origin in experimental design, especially when investigating how age-associated changes in matrix stiffness drive endothelial dysfunction and disease progression.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100140"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How PPAR-alpha mediated inflammation may affect the pathophysiology of chronic kidney disease","authors":"Sepiso K. Masenga ,&nbsp;Selam Desta ,&nbsp;Mark Hatcher ,&nbsp;Annet Kirabo ,&nbsp;Dexter L. Lee","doi":"10.1016/j.crphys.2024.100133","DOIUrl":"10.1016/j.crphys.2024.100133","url":null,"abstract":"<div><div>Chronic kidney disease (CKD) is a major risk factor for death in adults. Inflammation plays a role in the pathogenesis of CKD, but the mechanisms are poorly understood. Peroxisome proliferator-activated receptor alpha (PPAR-α) is a nuclear receptor and one of the three members (PPARα, PPARβ/δ, and PPARγ) of the PPARs that plays an important role in ameliorating pathological processes that accelerate acute and chronic kidney disease. Although other PPARs members are well studied, the role of PPAR-α is not well described and its role in inflammation-mediated chronic disease is not clear. Herein, we review the role of PPAR-α in chronic kidney disease with implications for the immune system.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100133"},"PeriodicalIF":2.1,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142722950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-based homologous expression system for in-vitro characterization of environmental effects on transmembrane peptide transport in fish","authors":"Pazit Con ,&nbsp;Jens Hamar ,&nbsp;Jakob Biran ,&nbsp;Dietmar Kültz ,&nbsp;Avner Cnaani","doi":"10.1016/j.crphys.2024.100118","DOIUrl":"10.1016/j.crphys.2024.100118","url":null,"abstract":"<div><p>All organisms encounter environmental changes that lead to physiological adjustments that could drive evolutionary adaptations. The ability to adjust performance in order to cope with environmental changes depends on the organism's physiological plasticity. These adjustments can be reflected in behavioral, physiological, and molecular changes, which interact and affect each other. Deciphering the role of molecular adjustments in physiological changes will help to understand how multiple levels of biological organization are synchronized during adaptations. Transmembrane transporters, which facilitate a cell's interaction with its surroundings, are prime targets for molecular studies of the environmental effects on an organism's physiology. Fish are subjected to environmental fluctuations and exhibit different coping mechanisms. To study the molecular adjustments of fish transporters to their external surrounding, suitable experimental systems must be established. The Mozambique tilapia (<em>Oreochromis mossambicus</em>) is an excellent model for environmental stress studies, due to its extreme salinity tolerance. We established a homologous cellular-based expression system and uptake assay that allowed us to study the effects of environmental conditions on transmembrane transport. We applied our expression system to investigate the effects of environmental conditions on the activity of PepT2, a transmembrane transporter critical in the absorption of dietary peptides and drugs. We created a stable, modified fish cell-line, in which we exogenously expressed the tilapia PepT2, and tested the effects of water temperature and salinity on the uptake of a fluorescent di-peptide, β-Ala-Lys-AMCA. While temperature affected only Vmax, medium salinity had a bi-directional effect, with significantly reduced Vmax in hyposaline conditions and significantly increased Km in hypersaline conditions. These assays demonstrate the importance of suitable experimental systems for fish ecophysiology studies. Furthermore, our <em>in-vitro</em> results show how the effect of hypersaline conditions on the transporter activity can explain expression shifts seen in the intestine of saltwater-acclimated fish, emphasizing the importance of complimentary studies in better understanding environmental physiology. This research highlights the advantages of using homologous expression systems to study environmental effects encountered by fish, in a relevant cellular context. The presented tools and methods can be adapted to study other transporters <em>in-vitro</em>.</p></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"7 ","pages":"Article 100118"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665944124000026/pdfft?md5=87c94ed733d490da908a966953cd895c&pid=1-s2.0-S2665944124000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139392587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a cajuína hydroelectrolytic drink on the physical performance and hydration status of recreational runners","authors":"Valmir Oliveira Silvino ,&nbsp;Mara Cristina Carvalho Batista ,&nbsp;Manoel Miranda Neto ,&nbsp;André Luiz Berzoti Ribeiro ,&nbsp;Paulo Pedro do Nascimento ,&nbsp;Esmeralda Maria Lustosa Barros ,&nbsp;Rayane Carvalho de Moura ,&nbsp;Karen Christie Gomes Sales ,&nbsp;Luanne Morais Vieira Galvão ,&nbsp;Lívio César Cunha Nunes ,&nbsp;Alessandra Durazzo ,&nbsp;Alexandre Sérgio Silva ,&nbsp;Marcos Antonio Pereira dos Santos","doi":"10.1016/j.crphys.2024.100119","DOIUrl":"https://doi.org/10.1016/j.crphys.2024.100119","url":null,"abstract":"<div><p>Cajuína is a processed drink derived from cashew and is widely consumed in the northeast region of Brazil. This study evaluated the effect of a cajuína-based hydroelectrolytic drink on the aerobic performance and hydration status of recreational runners. Seventeen males (31.9 ± 1.6 years, 51.0 ± 1.4 ml/kg/min) performed three time-to-exhaustion running sessions on a treadmill at 70% VO₂max, ingesting cajuína hydroelectrolytic drink (CJ), high carbohydrate commercial hydroelectrolytic drink (CH) and mineral water (W) every 15 min during the running test. The participants ran 80.3 ± 8.4 min in CJ, 70.3 ± 6.8 min in CH and 71.8 ± 6.9 min in W, with no statistical difference between procedures. Nevertheless, an effect size of η² = 0.10 (moderate) was observed. No statistical difference was observed in the concentrations of sodium, potassium, and osmolality in both serum and urine between the three conditions. However, the effect size was moderate (urine sodium) and high (serum sodium, potassium, and osmolality). Urine specific gravity, sweating rate and heart rate were not significantly different between drinks. The cajuína-based hydroelectrolytic drink promotes similar effects compared to commercial hydroelectrolytic drink and water, considering specific urine gravity, heart rate, sweating, and time to exhaustion in recreational runners.</p></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"7 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665944124000038/pdfft?md5=f3ece7ae8b06641a30b0fc016534eb92&pid=1-s2.0-S2665944124000038-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139709436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}