Current research in physiology最新文献

{"title":"How effective is online teaching of physiology modules? perception of Rwandan health sciences students","authors":"Abdullateef Isiaka Alagbonsi ,&nbsp;Mojeed Akorede Gbadamosi ,&nbsp;Mathieu Nemerimana ,&nbsp;Makinde V. Olubiyi ,&nbsp;Olufunke Onaadepo ,&nbsp;Akaninyene Ubong Ime ,&nbsp;Abdul-Rahuf Aderemi Feyitimi ,&nbsp;Ruth Wanjiru Mungai ,&nbsp;Florent Rutagarama ,&nbsp;Danilo Milanes Zambrano ,&nbsp;Noah Adavize Omeiza ,&nbsp;Simiat Olanike Elias","doi":"10.1016/j.crphys.2025.100181","DOIUrl":"10.1016/j.crphys.2025.100181","url":null,"abstract":"<div><h3>Background</h3><div>While blended teaching is approved in Rwandan medical education, the perceived effectiveness of online-only delivery for physiology modules remains unclear. This uncertainty limits its continued use. The present study assessed Rwandan health sciences students’ perceptions of the effectiveness of online teaching for physiology modules.</div></div><div><h3>Methods</h3><div>A total of 528 students from medicine and surgery (n = 300), pharmacy (n = 99), dentistry (n = 89), and clinical psychology (n = 40) programs at the University of Rwanda completed an online questionnaire. Data were analyzed using multivariable logistic regression and non-parametric tests (Mann-Whitney U, Kruskal-Wallis) with corresponding effect sizes.</div></div><div><h3>Results</h3><div>Female students (adjusted odds ratio (aOR) = 0.64, 95 % CI: 0.43–0.94, <em>p</em> = 0.024) had significantly lower odds of perceiving online teaching as effective, whereas Year 2 students (aOR = 1.63, 95 % CI: 1.05–2.55, <em>p</em> = 0.030) had significantly higher odds of doing so. Experiential factors strongly influenced perceived effectiveness: satisfaction with online teaching (aOR = 35.11, 95 % CI: 6.96–177.11, <em>p</em> &lt; 0.001), high interactivity (aOR = 5.17, 95 % CI: 2.46–10.87, <em>p</em> &lt; 0.001), and regular participation in discussions (aOR = 7.58, 95 % CI: 3.47–16.55, <em>p</em> &lt; 0.001) were associated with positive perceptions. Video conferencing was rated as most helpful for complex concepts (Kruskal-Wallis H (5) = 65.58, <em>p</em> &lt; 0.001). The predictive model (Nagelkerke R² = 0.629) strongly indicated that students perceived online teaching as comparably effective as face-to-face teaching.</div></div><div><h3>Conclusions</h3><div>Students’ perceptions of online teaching effectiveness are shaped more by interactivity, satisfaction, and active participation than by demographic characteristics. Educators should prioritize interactive, synchronous sessions and foster student engagement to increase acceptance of online physiology teaching in Rwanda.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"9 ","pages":"Article 100181"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145646003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of troxerutin on schizophrenia-like behaviors and oxidative damage in mice","authors":"Parham Malek ,&nbsp;Shahin Hassanpour ,&nbsp;Morteza Zendehdel","doi":"10.1016/j.crphys.2026.100183","DOIUrl":"10.1016/j.crphys.2026.100183","url":null,"abstract":"<div><div>The aim of this study was to investigate the influence of troxerutin on ketamine-induced schizophrenia-like behaviors in male mice, as well as its effects on antioxidant levels in brain tissue and serum cytokines. There were four experimental groups, each consisting of six male mice. The control group did not receive any treatment, the ketamine group was administered ketamine (30 mg/kg, ip), the troxerutin group was given troxerutin (150 mg/kg, orally), and the combined group was treated with both ketamine (30 mg/kg, ip) and troxerutin (150 mg/kg, orally). The animals were given troxerutin for a period of 30 days. Ketamine was injected once a day between days 16 and 30 of the study. At the end of the study, symptoms similar to schizophrenia were evaluated using novel object recognition, tail suspension, forced swimming, and open field assessments. Furthermore, measurements were taken of serum levels of TNF-α and IL-1β. Subsequently, animals were euthanized and the concentrations of malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) were assessed in both the brain cortex and sub-cortex. According to the results, ketamine resulted in a significant decrease in body weight and the frequency of crossings in the open field assay, while enhancing immobility duration in the tail suspension and forced swim assessments (P &lt; 0.05). Furthermore, ketamine significantly heightened memory deficits (P &lt; 0.05). Pre-treatment with troxerutin significantly reduced the effects of ketamine on body weight, open field test outcomes, and immobility duration (P &lt; 0.05). The results indicated that troxerutin can protect the brain from ketamine-induced issues in mice by reducing behavioral deficits, oxidative stress, and serum levels of inflammatory cytokines.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"9 ","pages":"Article 100183"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147802514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of safranal on anxiety and the MYD88/NF-kb signaling pathway in the hippocampus in a rat model of ulcerative colitis","authors":"Kaveh Rahimi,&nbsp;Atena Kooti,&nbsp;Nirvana Kafaie,&nbsp;Asal Chaboksavarian,&nbsp;Mohammad Javad Alimohammadi","doi":"10.1016/j.crphys.2025.100177","DOIUrl":"10.1016/j.crphys.2025.100177","url":null,"abstract":"<div><h3>Introduction</h3><div>Individuals with colitis are more likely to experience anxiety symptoms compared to those without the condition. However, the biological mechanisms linking colitis to anxiety remain unclear. This study investigated the potential effects of safranal on anxiety-like behaviors and the involvement of the MYD88/NF-κB signaling cascade within the hippocampus in a rat model of ulcerative colitis induced by acetic acid.</div></div><div><h3>Methods</h3><div>Thirty-two male rats were randomly divided into four groups: a control group, a colitis group, and two treatment groups receiving safranal at 72.75 or 145.5 mg/kg. The intervention lasted seven days. To confirm colitis induction, the Disease Activity Index (DAI) was assessed based on weight loss, stool consistency, and presence of blood. Anxiety-like behaviors were evaluated using the open field test and elevated plus maze. Molecular analyses measured hippocampal expression of TLR4, MYD88, and NF-κB, along with IL-6 and IL-1β protein levels.</div></div><div><h3>Results</h3><div>Safranal administration alleviated anxiety-like behaviors, as reflected by improved performance in both behavioral tests. Colitis induction was confirmed by a significant elevation in the DAI score, while safranal treatment at both doses significantly reduced this score, indicating attenuation of colitis severity. Safranal also decreased hippocampal IL-1β and IL-6 levels and suppressed TLR4, MYD88, and NF-κB expression, demonstrating inhibition of neuroinflammatory signaling.</div></div><div><h3>Conclusions</h3><div>These findings suggest that safranal exerts anxiolytic effects in experimental colitis, likely mediated through downregulation of the TLR4/MYD88/NF-κB pathway and reduced hippocampal neuroinflammation.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"9 ","pages":"Article 100177"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle activity of the lower extremities during exergames with varying movement demands in older adults (Registered Report - Stage I).","authors":"Thomas C Kosiolek, Dirk Möller, Eleftheria Giannouli","doi":"10.1016/j.crphys.2025.100158","DOIUrl":"10.1016/j.crphys.2025.100158","url":null,"abstract":"<p><strong>Objective: </strong>This study examines lower-leg muscle activity during four exergames with varying movement demands in older adults. A secondary objective is to compare individual muscle activity across the exergames.</p><p><strong>Background: </strong>Exergaming, which combines physical exercise with interactive video games, is increasingly used in older adults' rehabilitation, improving balance, strength, and cognitive function. Prior research suggests that different exergames engage specific motor functions. However, the activity of key lower-leg muscles-critical for balance-has not been systematically analyzed across exergames with varying movement demands (e.g., weight shifts, multidirectional steps, stepping in place, and walking).</p><p><strong>Methods: </strong>This cross-sectional study investigates muscle activity of the M. tibialis anterior, M. gastrocnemius, and M. soleus during four exergames using surface EMG. Muscle activity is quantified as Root Mean Square (RMS 100) values and normalized to the maximum voluntary contraction (MVC). Exergames are performed on the Dividat Senso platform, each emphasizing different movement patterns: multidirectional stepping, balance shifting, stepping in place, and whole-platform stepping. Thirty older adults (≥65 years) with no major functional or cognitive impairments (SPPB ≥7, MoCA ≥26) will be recruited. Exclusion criteria include severe motor impairments, mobility restrictions, extreme visual impairments, unstable cardiovascular conditions, or language barriers. Muscle activity will be compared across exergames using Multivariate Analysis of Variance (MANOVA), followed by univariate ANOVAs to identify specific differences.</p><p><strong>Potential significance: </strong>This study will identify muscle-specific activity patterns during exergames, informing targeted rehabilitation and exergame design. Findings may improve training strategies for balance enhancement and fall prevention in older adults, with potential benefits for healthcare cost reduction and quality of life.</p>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"100158"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The beneficial effect of propolis during an eight-weeks of resistance training on TNF-α and IL-6 genes expression in the kidney tissue of female Wistar rats undergoing testosterone enanthate consumption","authors":"Khadijeh Molaei ,&nbsp;Sanaz Mirzayan Shanjani ,&nbsp;Ali Gorzi ,&nbsp;Yaser Kazemzadeh ,&nbsp;Abdolali Banaeifar","doi":"10.1016/j.crphys.2025.100167","DOIUrl":"10.1016/j.crphys.2025.100167","url":null,"abstract":"<div><div>This study investigated the potential benefits of propolis in mitigating the adverse effects of testosterone enanthate on the gene expression levels of pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) in the kidney tissue of female Wistar rats undergoing resistance training. Testosterone enanthate, a commonly used anabolic steroid among female athletes, is known to impair kidney function through inflammatory and oxidative pathways. Twenty-four female Wistar rats (8 weeks old, weighing 208.22 ± 14.17 g) were obtained from the Pasteur Institute. After a one-week acclimatization period, the rats were randomly divided into three groups: 1) training + placebo (n = 8), 2) training + testosterone enanthate (n = 8), and 3) training + testosterone enanthate + propolis (n = 8). The 8-week resistance training program involved a 1-m vertical ladder with 26 steps and additional weights. Training occurred five days a week with two rest days. Rats in the testosterone enanthate group received injections of 20 mg/kg body weight. The other group received the same testosterone supplementation plus propolis via gavage at 400 mg/kg body weight, three times a week. TNF-α gene expression in the training + testosterone group was significantly higher than in the training + placebo (<em>P</em> &lt; 0.0001) and training + testosterone + propolis (<em>P</em> = 0.0025) groups. TNF-α gene expression in the training + testosterone + propolis group was also significantly higher than in the training + placebo group (<em>P</em> = 0.0001). Similarly, IL-6 gene expression in the training + testosterone group was significantly higher than in both the training + placebo (<em>P</em> &lt; 0.0001) and training + testosterone + propolis (<em>P</em> = 0.0142) groups. IL-6 gene expression in the training + testosterone + propolis group was significantly higher than in the training + placebo group (<em>P</em> = 0.0016). These findings suggest that propolis supplementation can partially attenuate the inflammatory effects of testosterone enanthate on kidney tissue, likely through modulation of cytokines gene expression, highlighting its potential therapeutic role in preserving kidney health during anabolic steroid exposure.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100167"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145323271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-generated multiple-choice questions in health science education: Stakeholder perspectives and implementation considerations","authors":"Matthew Reid ,&nbsp;Michelle French ,&nbsp;Stavroula Andreopoulos ,&nbsp;Christine Wong ,&nbsp;Nohjin Kee","doi":"10.1016/j.crphys.2025.100160","DOIUrl":"10.1016/j.crphys.2025.100160","url":null,"abstract":"<div><div>Multiple-choice questions (MCQs) are widely used in health science education because they are an efficient way to evaluate knowledge from simple recall to complex clinical reasoning. The creation of high-quality MCQs, however, can be time-consuming and requires expertise in question composition. Advancements in artificial intelligence (AI), especially large language models (LLMs), offer the potential to allow for the rapid generation of high-quality, consistent, and course-specific MCQs. Here we discuss the potential benefits and drawbacks of the use of this technology in the generation of MCQs, including ensuring the accuracy and fairness of questions, along with technical, ethical, and privacy considerations. We offer practical guiding principles for the implementation of AI-generated MCQs and outline future research areas related to their impact on student learning and educational quality.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100160"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"You don't know what you don't know; using high school outreach to improve awareness of bioscience-based careers and higher education","authors":"Christine Greensmith ,&nbsp;David Greensmith","doi":"10.1016/j.crphys.2025.100151","DOIUrl":"10.1016/j.crphys.2025.100151","url":null,"abstract":"<div><div>When considering the diversity of students in higher education, an important but frequently overlooked characteristic is socioeconomic background. It is well known that those from socially disadvantaged backgrounds are less likely to progress to higher education, and accounts for an associated lack of diversity in the STEM workplace. The reasons for this are many and complex, though a lack of awareness of STEM-based education thence career pathways among secondary school learners remains a key contributor. To address this, we designed an adaptable and scalable high school outreach programme that sought to raise STEM (with a focus on bioscience) awareness through events that could be readily adapted to meet high school needs and resource constraints. Learner perceptions were recorded using a pre- and post-event questionnaire. Following the event, awareness of bioscience-based careers and the required prerequisite skills and qualifications were increased by 58 and 53 % respectively. The degree to which learners were considering a bioscience-based career was increased by 43 %. Though interest in attending university to study STEM was unaltered, awareness of the qualifications required to progress to university was increased by 58 %. These findings suggest that outreach events are an effective way to raise general awareness of STEM-based higher education learning thence careers and highlight the importance of tailoring outreach events to meet school and learner needs.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100151"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential responses to acute endurance exercise-induced signaling protein phosphorylation and abundance alterations in whole murine gastrocnemius muscle and isolated myofibers","authors":"Kazuki Uemichi ,&nbsp;Takanaga Shirai ,&nbsp;Shunsuke Sugiyama ,&nbsp;Tohru Takemasa","doi":"10.1016/j.crphys.2025.100173","DOIUrl":"10.1016/j.crphys.2025.100173","url":null,"abstract":"<div><div>Skeletal muscle is composed of diverse cell types, including myofibers. In this study, we investigated how acute endurance exercise could induce signaling protein phosphorylation and abundance alterations using protein lysate extracted from whole-muscle tissue or isolated myofibers. We subjected 8-week-old male Institute Cancer Research mice to a single bout of treadmill running-based endurance exercise, and evaluated the signaling protein expression responses in the whole gastrocnemius muscle and isolated myofibers, obtained by incubation in 0.2 % collagenase/medium, immediately after exercise. Our results revealed that exercise activated mitochondrial biogenesis- and protein anabolism-related signaling, including 5′-adenosine monophosphate-activated kinase and Akt/p70 S6 kinases, respectively, as well as increased glucose metabolism-related proteins in whole-muscle samples immediately after exercise. However, these signaling responses were not present in the muscle fiber lysate and mitochondrial oxidative phosphorylation-related protein abundance significantly decreased postexercise. Our data suggest that signaling protein activation and quantitative alterations in myofibers digested in collagenase-dissolved medium post acute exercise do not necessarily reflect the expression responses in whole skeletal muscle tissue.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100173"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145518951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of neural mechanisms underlying antidepressant-like property of Ziziphora clinopodioides Lam. essential oil using mouse forced swimming test: Involvement of the monoaminergic systems","authors":"Saeedeh Ghaffarzadeh Shirabad,&nbsp;Samad Alimohammadi","doi":"10.1016/j.crphys.2025.100174","DOIUrl":"10.1016/j.crphys.2025.100174","url":null,"abstract":"<div><h3>Objective</h3><div><em>Ziziphora clinopodioides</em> has been valued in Iranian traditional medicine for various medicinal applications. This novel study was conducted to assess the antidepressant-like effect of the essential oil of <em>Ziziphora clinopodioides</em> (EOZC) and to identify the possible mechanisms contributing to this action through forced swimming test (FST).</div></div><div><h3>Methods</h3><div>The chemical profile of EOZC obtained by GC-MS. The mice received EOZC (10, 20, and 40 mg/kg) 1 h before the FST intraperitoneally. Moreover, naloxone (non-selective antagonist for opioid receptor subtypes, 1 mg/kg), prazosin (α_1-adrenergic receptor antagonist, 1 mg/kg), yohimbine (α_2-adrenergic receptor antagonist, 1 mg/kg), propranolol (β-adrenergic receptor antagonist, 2 mg/kg), WAY100635 (selective 5-HT_1A receptor antagonist, 0.1 mg/kg), ondansetron (5-HT₃ receptor antagonist, 1 mg/kg), haloperidol (non-selective dopamine receptor blocker, 0.2 mg/kg), SCH23390 (selective dopamine D₁ receptor blocker, 0.05 mg/kg), sulpiride (selective dopamine D₂ receptor blocker, 50 mg/kg) and flumazenil (GABA_A/BDZ receptor antagonist, 10 mg/kg) were used to ascertain the neural pathways implicated in the antidepressant-like response of EOZC.</div></div><div><h3>Results</h3><div>The GC-MS evaluation demonstrated that predominant components of EOZC comprised carvacrol (65.22 %), thymol (19.51 %), p-cymene (4.86 %), γ-terpinene (4.63 %) and E-Caryophyllene (1.07 %). EOZC exhibited a significant dose-dependent effect that resulted in a marked decrease in the duration of immobility time (P &lt; 0.05). The antidepressant-like action of EOZC was reversed by prazosin, yohimbine, WAY100635, ondansetron, haloperidol, SCH23390 and sulpiride. However, this effect remained unaffected by naloxone, propranolol and flumazenil.</div></div><div><h3>Conclusion</h3><div>These findings indicate that EOZC elicits antidepressant-like response, which relies on its interaction with noradrenergic, serotonergic and dopaminergic pathways.</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100174"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum electrolytes and blood urea nitrogen changes in end-stage renal disease patients undergoing contemporary haemodialysis: A multi-center cross-sectional study","authors":"Wastina Bitewlign ,&nbsp;Mohammed Jemal ,&nbsp;Enyew Fenta Mengistu ,&nbsp;Hiwot Tezera Endale ,&nbsp;Tadesse Asmamaw Dejenie ,&nbsp;Kibur Hunie Tesfa","doi":"10.1016/j.crphys.2025.100175","DOIUrl":"10.1016/j.crphys.2025.100175","url":null,"abstract":"<div><h3>Background</h3><div>Correction of electrolyte imbalance and adequate haemodialysis (HD) minimizes disease complications and hospitalization. Despite the problem, there is a paucity of data regarding the assessment of serum electrolytes and blood urea nitrogen changes (BUN) in end-stage renal disease patients undergoing contemporary HD in Ethiopia.</div></div><div><h3>Objective</h3><div>The objective of this study was to assess serum electrolytes and BUN changes in patients with End-Stage Renal Disease undergoing contemporary HD in Ethiopia.</div></div><div><h3>Methods</h3><div>A multi-center cross-sectional study was conducted from June 1 to August 10, 2021. The levels of serum electrolytes and BUN before and immediately after HD were measured using an ion-selective electrode and a spectrophotometry analyzer, respectively. Data analysis was performed using SPSS version 26. Descriptive statistics were performed for descriptive variables, and continuous variables were compared as the mean ± SD using a paired <em>t</em>-test. Pearson's correlation coefficient with a 95 % confidence level was used to measure the strength of the association. P-values &lt; 0.05 were declared statistically significant.</div></div><div><h3>Results</h3><div>The mean ± SD age of the participants was 44.19 ± 15.25 years. The mean ± SD duration of HD was 1.71 ± 1.65 years, and 52 (72.2 %) patients received dialysis twice per week. Compared with immediate postdialysis concentration, a statistically significant decrease was noted for potassium (1.74 ± 1.11 mmol/L, <em>p &lt; 0.001</em>), magnesium (0.42 ± 0.35 mmol/L, <em>p &lt; 0.001</em>), phosphorus (0.62 ± 0.49 mmol/L, <em>p &lt; 0.001</em>), and BUN (31.9 ± 10.4 mmol/L, <em>p &lt; 0.001</em>). This study showed that 43 (59.7 %) end-stage renal disease patients received adequate HD.</div></div><div><h3>Conclusion</h3><div>This study found a significant decrease in serum potassium, magnesium, phosphorus, and BUN following dialysis. The urea reduction ratio revealed a minimum adequate HD session among end-stage renal disease patients on maintenance haemodialysis (MHD).</div></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"8 ","pages":"Article 100175"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}