Communications engineering最新文献_第2页

A wireless W-band 3D-printed temperature sensor based on a three-dimensional photonic crystal operating beyond 1000 ∘C 基于三维光子晶体的无线 W 波段三维打印温度传感器，工作温度超过 1000 ∘C。

Communications engineering Pub Date : 2024-09-23 DOI: 10.1038/s44172-024-00282-5

Jesús Sánchez-Pastor, Petr Kadĕra, Masoud Sakaki, Rolf Jakoby, Jaroslav Lacik, Niels Benson, Alejandro Jiménez-Sáez

{"title":"A wireless W-band 3D-printed temperature sensor based on a three-dimensional photonic crystal operating beyond 1000 ∘C","authors":"Jesús Sánchez-Pastor, Petr Kadĕra, Masoud Sakaki, Rolf Jakoby, Jaroslav Lacik, Niels Benson, Alejandro Jiménez-Sáez","doi":"10.1038/s44172-024-00282-5","DOIUrl":"10.1038/s44172-024-00282-5","url":null,"abstract":"In addressing sensing in harsh and dynamic environments, there are no available millimeter-wave chipless and wireless sensors capable of continuous operation at extremely high temperatures. Here we present a fully dielectric wireless temperature sensor capable of operating beyond 1000 ∘C. The sensor uses high-Q cavities embedded within a three-dimensional photonic crystal resonating at 83.5 GHz and 85.5 GHz, and a flattened Luneburg lens enhances its readout range. The sensor is additively manufactured using Lithography-based Ceramic Manufacturing in Alumina (Al2O3). Despite the clutter, its frequency-coded response remains detectable from outside the furnace at 50 cm and at temperatures up to 1200 ∘C. It is observed that the resonance frequencies shift with temperature. This shift is linked to a change in the dielectric properties of Al2O3, which are estimated up to 1200 ∘C and show good agreement with literature values. The sensor is thus highly suitable for millimeter-wave applications in dynamic, cluttered, and high-temperature environments. Jesús Sánchez-Pastor and colleagues demonstrate a ceramic W-band wireless temperature sensor leveraging high-Q cavities within a three-dimensional photonic crystal. The sensor is additively manufactured in Alumina and can continuously operate at extreme temperatures above 1000 ∘C with potential applications in dynamic, cluttered, and high-temperature environments.","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44172-024-00282-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acoustically semitransparent nanofibrous meshes appraised by high signal-to-noise-ratio MEMS microphones 通过高信噪比 MEMS 麦克风评估半透明纳米纤维网。

Communications engineering Pub Date : 2024-09-23 DOI: 10.1038/s44172-024-00283-4

Hutomo Suryo Wasisto, Sebastian Anzinger, Giovanni Acanfora, Aloysius Farrel, Valentina Sabatini, Elisa Grimoldi, Vasco Marelli, Nikita Ovsiannikov, Konstantin Tkachuk, Giordano Tosolini, Carmine Lucignano, Marco Mietta, Guangzhao Zhang, Marc Fueldner, Erwin Peiner

{"title":"Acoustically semitransparent nanofibrous meshes appraised by high signal-to-noise-ratio MEMS microphones","authors":"Hutomo Suryo Wasisto, Sebastian Anzinger, Giovanni Acanfora, Aloysius Farrel, Valentina Sabatini, Elisa Grimoldi, Vasco Marelli, Nikita Ovsiannikov, Konstantin Tkachuk, Giordano Tosolini, Carmine Lucignano, Marco Mietta, Guangzhao Zhang, Marc Fueldner, Erwin Peiner","doi":"10.1038/s44172-024-00283-4","DOIUrl":"10.1038/s44172-024-00283-4","url":null,"abstract":"Microelectromechanical system-based microphones demand high ingress protection levels with regard to their use in harsh environment. Here, we develop environmental protective components comprising polyimide nanofibers combined onto polyether ether ketone fabric meshes and subsequently appraise their impact on the electroacoustic properties of high signal-to-noise-ratio microelectromechanical system-based microphones via industry-standard characterizations and theoretical simulations. Being placed directly on top of the microphone sound port, the nanofiber mesh die-cut parts with an inner diameter of 1.4 mm result in signal-to-noise-ratio and insertion losses of (2.05 ± 0.16) dB(A) and (0.30 ± 0.11) dBFS, respectively, in electroacoustic measurements. Hence, a high signal-to-noise-ratio value of (70.05 ± 0.17) dB(A) can be maintained by the mesh-protected microphone system. Due to their high temperature stability, acoustic performance, environmental robustness, and industry-scale batch production, these nanofibrous meshes reveal high potential to be practically implemented in high-market-volume applications of packaged microelectromechanical system-based microphones. Hutomo Suryo Wasisto and colleagues develop a nanofiber-based mesh for improving the ingress protection level of microelectromechanical system (MEMS)-based microphone. Their device demonstrates high acoustic performance and environmental robustness.","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44172-024-00283-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scintillation event imaging with a single photon avalanche diode camera 利用单光子雪崩二极管相机进行闪烁事件成像

Communications engineering Pub Date : 2024-09-18 DOI: 10.1038/s44172-024-00281-6

Alex Bocchieri, Edoardo Charbon, Andreas Velten

{"title":"Scintillation event imaging with a single photon avalanche diode camera","authors":"Alex Bocchieri, Edoardo Charbon, Andreas Velten","doi":"10.1038/s44172-024-00281-6","DOIUrl":"10.1038/s44172-024-00281-6","url":null,"abstract":"Position and time measurements of scintillation events encode information about the radiation source. Single photon avalanche diode (SPAD) arrays offer multiple-megapixel spatial resolution and tens of picoseconds temporal resolution for detecting single photons. Current lensless designs for measuring scintillation events use sensors that are lower in spatial resolution. Camera-based designs use sensors that are lower in temporal resolution or readout rate and cannot image individual interactions. Here we propose to image scintillation events in a thick, monolithic scintillator using a high-resolution SPAD camera. We demonstrate that a commercial SPAD camera is able to gather sufficient signal to image individual scintillation events and observe 3D shifts in their spatial distribution. Simulations show that a SPAD camera can localize individual scintillation events in 3D. We report direct imaging of gamma-ray interactions in a scintillator with a SPAD camera. The proposed design may allow to measure complex signatures of individual particles interacting in the scintillator. Alex Bocchieri and colleagues propose an imaging technique in a thick, monolithic scintillator using a high-resolution SPAD camera. They report a direct imaging of gamma-ray interactions in a scintillator.","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44172-024-00281-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactive computer-aided diagnosis on medical image using large language models 利用大型语言模型对医学影像进行交互式计算机辅助诊断

Communications engineering Pub Date : 2024-09-17 DOI: 10.1038/s44172-024-00271-8

Sheng Wang, Zihao Zhao, Xi Ouyang, Tianming Liu, Qian Wang, Dinggang Shen

{"title":"Interactive computer-aided diagnosis on medical image using large language models","authors":"Sheng Wang, Zihao Zhao, Xi Ouyang, Tianming Liu, Qian Wang, Dinggang Shen","doi":"10.1038/s44172-024-00271-8","DOIUrl":"10.1038/s44172-024-00271-8","url":null,"abstract":"Computer-aided diagnosis (CAD) has advanced medical image analysis, while large language models (LLMs) have shown potential in clinical applications. However, LLMs struggle to interpret medical images, which are critical for decision-making. Here we show a strategy integrating LLMs with CAD networks. The framework uses LLMs’ medical knowledge and reasoning to enhance CAD network outputs, such as diagnosis, lesion segmentation, and report generation, by summarizing information in natural language. The generated reports are of higher quality and can improve the performance of vision-based CAD models. In chest X-rays, an LLM using ChatGPT improved diagnosis performance by 16.42 percentage points compared to state-of-the-art models, while GPT-3 provided a 15.00 percentage point F1-score improvement. Our strategy allows accurate report generation and creates a patient-friendly interactive system, unlike conventional CAD systems only understood by professionals. This approach has the potential to revolutionize clinical decision-making and patient communication. Wang et al. developed a machine learning strategy for improving large language model to understand and analyse visual medical information. Their framework seamlessly integrates medical image computer-aided diagnosis networks with large language models, converting medical image inputs into a clear and concise textual summary of the patient’s condition.","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44172-024-00271-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergizing physics and machine learning for advanced battery management 将物理学与机器学习相结合，实现先进的电池管理

Communications engineering Pub Date : 2024-09-17 DOI: 10.1038/s44172-024-00273-6

Manashita Borah, Qiao Wang, Scott Moura, Dirk Uwe Sauer, Weihan Li

{"title":"Synergizing physics and machine learning for advanced battery management","authors":"Manashita Borah, Qiao Wang, Scott Moura, Dirk Uwe Sauer, Weihan Li","doi":"10.1038/s44172-024-00273-6","DOIUrl":"10.1038/s44172-024-00273-6","url":null,"abstract":"Improving battery health and safety motivates the synergy of a powerful duo: physics and machine learning. Through seamless integration of these disciplines, the efficacy of mathematical battery models can be significantly enhanced. This paper delves into the challenges and potentials of managing battery health and safety, highlighting the transformative impact of integrating physics and machine learning to address those challenges. Based on our systematic review in this context, we outline several future directions and perspectives, offering a comprehensive exploration of efficient and reliable approaches. Our analysis emphasizes that the integration of physics and machine learning stands as a disruptive innovation in the development of emerging battery health and safety management technologies. Lithium-ion batteries are integral to modern technologies but the sustainability of long-term battery health is a significant and persistent challenge. In this perspective Borah and colleagues discuss the integration of physics and machine learning to support developments in battery performance and safety.","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44172-024-00273-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A full-custom fully implantable cochlear implant system validated in vivo with an animal model 通过动物模型在体内验证的全定制全植入式人工耳蜗系统

Communications engineering Pub Date : 2024-09-14 DOI: 10.1038/s44172-024-00275-4

Hasan Uluşan, M. Berat Yüksel, Özlem Topçu, H. Andaç Yiğit, Akın M. Yılmaz, Mert Doğan, Nagihan Gülhan Yasar, İbrahim Kuyumcu, Aykan Batu, Nebil Göksu, M. Birol Uğur, Haluk Külah

{"title":"A full-custom fully implantable cochlear implant system validated in vivo with an animal model","authors":"Hasan Uluşan, M. Berat Yüksel, Özlem Topçu, H. Andaç Yiğit, Akın M. Yılmaz, Mert Doğan, Nagihan Gülhan Yasar, İbrahim Kuyumcu, Aykan Batu, Nebil Göksu, M. Birol Uğur, Haluk Külah","doi":"10.1038/s44172-024-00275-4","DOIUrl":"10.1038/s44172-024-00275-4","url":null,"abstract":"Realizations of fully implantable cochlear implants (FICIs) for providing adequate solution to esthetic concerns and frequent battery replacement have lacked of addressing system level criteria as a complete device. Here, we present a full-custom FICI that considers design of both an implantable sensor for wide range sound sensing and a signal conditioning circuit for electrical stimulation of the auditory nerve. The microelectromechanical system (MEMS)-based acoustic sensor utilizes multiple cantilever beam structures to sense and filter the mechanical vibrations on the ossicular chain. The area optimized bilayer design of the piezoelectric sensor met with the volume limitation in the middle ear while achieving high signal-to-noise-ratio. The sensor outputs are processed by a current mode low-power signal conditioning circuit that stimulates the auditory neurons through intracochlear electrodes. The FICI is validated with an in vivo model where the electrical auditory brainstem response (eABR) of the animal was observed while applying sound excitation. The eABR results demonstrate that the system is able to evoke responses in the auditory nerves of a guinea pig for sound range of 45–100 dB SPL within the selected frequency bands. Dr Ulusan and colleagues design a fully implantable cochlear implant and demonstrate functionality using an in vivo model where sound vibrations within a range of 45–100 dB SPL can be detected and filtered. The design uses a MEMS-based acoustic sensor coupled with a low-power signal-conditioning circuit that will also ensure long operating times.","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44172-024-00275-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142234045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-view neural 3D reconstruction of micro- and nanostructures with atomic force microscopy 利用原子力显微镜对微观和纳米结构进行多视角神经三维重建

Communications engineering Pub Date : 2024-09-12 DOI: 10.1038/s44172-024-00270-9

Shuo Chen, Mao Peng, Yijin Li, Bing-Feng Ju, Hujun Bao, Yuan-Liu Chen, Guofeng Zhang

{"title":"Multi-view neural 3D reconstruction of micro- and nanostructures with atomic force microscopy","authors":"Shuo Chen, Mao Peng, Yijin Li, Bing-Feng Ju, Hujun Bao, Yuan-Liu Chen, Guofeng Zhang","doi":"10.1038/s44172-024-00270-9","DOIUrl":"10.1038/s44172-024-00270-9","url":null,"abstract":"Atomic Force Microscopy (AFM) is a widely employed tool for micro- and nanoscale topographic imaging. However, conventional AFM scanning struggles to reconstruct complex 3D micro- and nanostructures precisely due to limitations such as incomplete sample topography capturing and tip-sample convolution artifacts. Here, we propose a multi-view neural-network-based framework with AFM, named MVN-AFM, which accurately reconstructs surface models of intricate micro- and nanostructures. Unlike previous 3D-AFM approaches, MVN-AFM does not depend on any specially shaped probes or costly modifications to the AFM system. To achieve this, MVN-AFM employs an iterative method to align multi-view data and eliminate AFM artifacts simultaneously. Furthermore, we apply the neural implicit surface reconstruction technique in nanotechnology and achieve improved results. Additional extensive experiments show that MVN-AFM effectively eliminates artifacts present in raw AFM images and reconstructs various micro- and nanostructures, including complex geometrical microstructures printed via two-photon lithography and nanoparticles such as poly(methyl methacrylate) (PMMA) nanospheres and zeolitic imidazolate framework-67 (ZIF-67) nanocrystals. This work presents a cost-effective tool for micro- and nanoscale 3D analysis. Shuo Chen and colleagues present a cost-effective neural network-based method to deal with tip-sample convolution artifacts in atomic force microscopy. Their method merges multiview atomic force microscopy images into precise 3D models of complex micro- and nanostructures.","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44172-024-00270-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142234039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seamlessly merging radar ranging and imaging, wireless communications, and spectrum sensing for 6G empowered by microwave photonics 无缝融合雷达测距与成像、无线通信和频谱传感技术，实现由微波光子技术助力的 6G

Communications engineering Pub Date : 2024-09-12 DOI: 10.1038/s44172-024-00279-0

Taixia Shi, Yang Chen, Jianping Yao

{"title":"Seamlessly merging radar ranging and imaging, wireless communications, and spectrum sensing for 6G empowered by microwave photonics","authors":"Taixia Shi, Yang Chen, Jianping Yao","doi":"10.1038/s44172-024-00279-0","DOIUrl":"10.1038/s44172-024-00279-0","url":null,"abstract":"To facilitate intelligent interconnection among people, machines, and things, the next generation of communication technology must incorporate various sensing functions besides high-speed wireless communications. Integration of radar, wireless communications, and spectrum sensing is being investigated for 6G with increased spectral efficiency, enhanced system integration, and reduced cost. Microwave photonics, a technique that combines microwave engineering and photonic technology is considered an effective solution for implementing the integration and breaking the bottleneck problems of electronic solutions. Here, we show a photonics-assisted joint radar, wireless communications, and spectrum sensing system that enables precise perception of the surrounding physical and electromagnetic environments while maintaining high-speed communication. Communication signals and frequency-sweep signals are merged optically using a shared system architecture and hardware to achieve signal level sharing, ultimately simultaneously achieving high-accuracy radar ranging and imaging with a measurement error within ± 4 cm and an imaging resolution of 25 × 24.7 mm, high-data-rate wireless communications at 2 Gbaud, and wideband spectrum sensing with a frequency measurement error within ±10 MHz in a 6 GHz bandwidth. Taixia Shi and colleagues demonstrate a microwave photonics system with integrated capabilities of radar, communication, and spectrum sensing for 6G technologies, simultaneously achieving high-accuracy radar ranging and imaging, high-data-rate wireless communications, and wideband spectrum sensing.","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44172-024-00279-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142234032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bidirectional wavelength-division-multiplexing fibre-free-space optical communications using polarisation multiplexing technique and tunable optical vestigial sideband filter 利用偏振多路复用技术和可调谐光学边带滤波器实现双向波分复用光纤自由空间光通信

Communications engineering Pub Date : 2024-09-09 DOI: 10.1038/s44172-024-00277-2

Hsiao-Mei Lin, Chia-Peng Wang, Hai-Han Lu, Stotaw Talbachew Hayle, Xu-Hong Huang, Wei-Wen Hsu, Yu-Chen Chung, Yu-Yao Bai, Kelper Okram, Jia-Ming Lu

{"title":"Bidirectional wavelength-division-multiplexing fibre-free-space optical communications using polarisation multiplexing technique and tunable optical vestigial sideband filter","authors":"Hsiao-Mei Lin, Chia-Peng Wang, Hai-Han Lu, Stotaw Talbachew Hayle, Xu-Hong Huang, Wei-Wen Hsu, Yu-Chen Chung, Yu-Yao Bai, Kelper Okram, Jia-Ming Lu","doi":"10.1038/s44172-024-00277-2","DOIUrl":"10.1038/s44172-024-00277-2","url":null,"abstract":"To address the growing demand from emerging applications, high transmission capacity is essential for both fibre backbones and last-mile communications. This can be achieved by integrating optical fibre with optical wireless technologies, facilitating the development of fibre-free-space optical communications. Here we report a bidirectional wavelength-division-multiplexing fibre-free-space optical communication employing polarisation multiplexing technique and tunable optical vestigial sideband filter. The transmission capacity is considerably increased by integrating the polarisation multiplexing technique with the wavelength-division-multiplexing scheme. The transmission performance is extensively enhanced by using a tunable optical vestigial sideband filter and vestigial sideband-four-level pulse amplitude modulation. Moreover, the optical wireless link is substantially extended through the operation of triplet lenses. Low bit error rates and clear vestigial sideband-four-level pulse amplitude modulation eye diagrams are attained with a high aggregate transmission capacity of 480 Gb/s for downstream/upstream transmission. This capability of bidirectional fibre-free-space optical communications holds substantial potential for enhancing advanced wired-wireless communications. Hsiao-Mei Lin and coauthors achieve bidirectional communication using polarisation multiplexing and a tunable optical vestigial sideband filter. The system transmitted data over a total distance of 31.6 km, including both single-mode fibre and free-space optical links, achieving an aggregate capacity of 480 Gb/s for downstream and upstream transmissions.","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44172-024-00277-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142165818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal stem cell cryopreservation with cavitation-mediated trehalose treatment 通过空化介导的三卤糖处理冷冻间充质干细胞

Communications engineering Pub Date : 2024-09-09 DOI: 10.1038/s44172-024-00265-6

Carla V. Fuenteslópez, Michael Gray, Simge Bahcevanci, Alexander Martin, Cameron A. B. Smith, Constantin Coussios, Zhanfeng Cui, Hua Ye, Viorica Patrulea

{"title":"Mesenchymal stem cell cryopreservation with cavitation-mediated trehalose treatment","authors":"Carla V. Fuenteslópez, Michael Gray, Simge Bahcevanci, Alexander Martin, Cameron A. B. Smith, Constantin Coussios, Zhanfeng Cui, Hua Ye, Viorica Patrulea","doi":"10.1038/s44172-024-00265-6","DOIUrl":"10.1038/s44172-024-00265-6","url":null,"abstract":"Dimethylsulfoxide (DMSO) has conventionally been used for cell cryopreservation both in research and in clinical applications, but has long-term cytotoxic effects. Trehalose, a natural disaccharide, has been proposed as a non-toxic cryoprotectant. However, the lack of specific cell membrane transporter receptors inhibits transmembrane transport and severely limits its cryoprotective capability. This research presents a method to successfully deliver trehalose into mesenchymal stem cells (MSCs) using ultrasound in the presence of microbubbles. The optimised trehalose concentration was shown to be able to not only preserve membrane integrity and cell viability but also the multipotency of MSCs, which are essential for stem cell therapy. Confocal imaging revealed that rhodamine-labelled trehalose was transported into cells rather than simply attached to the membrane. Additionally, the membranes were successfully preserved in lyophilised cells. This study demonstrates that ultrasonication with microbubbles facilitated trehalose delivery, offering promising cryoprotective capability without the cytotoxicity associated with DMSO-based methods. The team led by Dr. Patrulea propose a method to use trehalose as a non-toxic cryopreservation & lyophilisation agent. They demonstrate how ultrasound & microbubbles can be used to successfully internalise trehalose into mesenchymal stem cells, preventing cryodamage.","PeriodicalId":72644,"journal":{"name":"Communications engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44172-024-00265-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142165802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0