Advanced drug delivery reviews最新文献_第7页

Current issues in optical monitoring of drug delivery via hair follicles 毛囊给药光学监测的现状

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115477

Yulia I. Svenskaya , Roman A. Verkhovskii , Sergey M. Zaytsev , Juergen Lademann , Elina A. Genina

{"title":"Current issues in optical monitoring of drug delivery via hair follicles","authors":"Yulia I. Svenskaya , Roman A. Verkhovskii , Sergey M. Zaytsev , Juergen Lademann , Elina A. Genina","doi":"10.1016/j.addr.2024.115477","DOIUrl":"10.1016/j.addr.2024.115477","url":null,"abstract":"<div><div>Drug delivery via hair follicles has attracted much research attention due to its potential to serve for both local and systemic therapeutic purposes. Recent studies on topical application of various particulate formulations have demonstrated a great role of this delivery route for targeting numerous cell populations located in skin and transporting the encapsulated drug molecules to the bloodstream. Despite a great promise of follicle-targeting carriers, their clinical implementation is very rare, mostly because of their poorer characterization compared to conventional topical dosage forms, such as ointments and creams, which have a history spanning over a century. Gathering as complete information as possible on the intrafollicular penetration depth, storage, degradation/metabolization profiles of such carriers and the release kinetics of drugs they contain, as well as their impact on skin health would significantly contribute to understanding the pros and cons of each carrier type and facilitate the selection of the most suitable candidates for clinical trials. Optical imaging and spectroscopic techniques are extensively applied to study dermal penetration of drugs. Current paper provides the state-of-the-art overview of techniques, which are used in optical monitoring of follicular drug delivery, with a special focus on non-invasive <em>in vivo</em> methods. It discusses key features, advantages and limitations of their use, as well as provide expert perspectives on future directions in this field.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115477"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142742743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra-tumoral bacteria in breast cancer and intervention strategies 乳腺癌肿瘤内细菌及其干预策略

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2025.115516

Ting Hou , Xiaoling Huang , Jiahui Lai , Dongfang Zhou

{"title":"Intra-tumoral bacteria in breast cancer and intervention strategies","authors":"Ting Hou , Xiaoling Huang , Jiahui Lai , Dongfang Zhou","doi":"10.1016/j.addr.2025.115516","DOIUrl":"10.1016/j.addr.2025.115516","url":null,"abstract":"<div><div>The microbiome, consisting of a wide range of both beneficial and harmful microorganisms, is vital to various physiological and pathological processes in the human body, including cancer pathogenesis. Tumor progression is often accompanied by the destruction of the vascular system, allowing bacteria to circulate into the tumor area and flourish in an immunosuppressive environment. Microbes are recognized as significant components of the tumor microenvironment. Recent research has increasingly focused on the role of intra-tumoral bacteria in the onset, progression, and treatment of breast cancer—the most prevalent cancer among women. This review elucidates the potential mechanisms by which intra-tumoral bacteria impact breast cancer and discusses different therapeutic approaches aimed at targeting these bacteria. It provides essential insights for enhancing existing treatment paradigms while paving the way for novel anticancer interventions. As our understanding of the microbiome’s intricate relationship with cancer deepens, it opens avenues for groundbreaking strategies that could redefine oncology.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115516"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D extrusion bioprinting of microbial inks for biomedical applications 用于生物医学应用的微生物油墨的3D挤出生物打印

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115505

Nicolas Burns , Arjun Rajesh , Avinash Manjula-Basavanna , Anna Duraj-Thatte

{"title":"3D extrusion bioprinting of microbial inks for biomedical applications","authors":"Nicolas Burns , Arjun Rajesh , Avinash Manjula-Basavanna , Anna Duraj-Thatte","doi":"10.1016/j.addr.2024.115505","DOIUrl":"10.1016/j.addr.2024.115505","url":null,"abstract":"<div><div>In recent years, the field of 3D bioprinting has witnessed the intriguing development of a new type of bioink known as microbial inks. Bioinks, typically associated with mammalian cells, have been reimagined to involve microbes, enabling many new applications beyond tissue engineering and regenerative medicine. This review presents the latest advancements in microbial inks, including their definition, types, composition, salient characteristics, and biomedical applications. Herein, microbes are genetically engineered to produce 1) extrudable bioink and 2) life-like functionalities such as self-regeneration, self-healing, self-regulation, biosynthesis, biosensing, biosignaling, biosequestration, etc. We also discuss some of the promising applications of 3D extrusion printed microbial inks, such as 1) drugs and probiotics delivery, 2) metabolite production, 3) tissue engineering, 4) bioremediation, 5) biosensors and bioelectronics, 6) biominerals and biocomposites, and 7) infectious disease modeling. Finally, we describe some of the current challenges of microbial inks that needs to be addressed in the coming years, to make a greater impact in health science and technology and many other fields.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115505"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Droplet-based 3D bioprinting for drug delivery and screening 用于药物输送和筛选的基于液滴的3D生物打印

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115486

Heqi Xu , Shaokun Zhang , Kaidong Song , Huayong Yang , Jun Yin , Yong Huang

{"title":"Droplet-based 3D bioprinting for drug delivery and screening","authors":"Heqi Xu , Shaokun Zhang , Kaidong Song , Huayong Yang , Jun Yin , Yong Huang","doi":"10.1016/j.addr.2024.115486","DOIUrl":"10.1016/j.addr.2024.115486","url":null,"abstract":"<div><div>Recently, the conventional criterion of “one-size-fits-all” is not qualified for each individual patient, requiring precision medicine for enhanced therapeutic effects. Besides, drug screening is a high-cost and time-consuming process which requires innovative approaches to facilitate drug development rate. Benefiting from consistent technical advances in 3D bioprinting techniques, droplet-based 3D bioprinting techniques have been broadly utilized in pharmaceutics due to the noncontact printing mechanism and precise control on the deposition position of droplets. More specifically, cell-free/cell-laden bioinks which are deposited for the fabrication of drug carriers/3D tissue constructs have been broadly utilized for precise drug delivery and high throughput drug screening, respectively. This review summarizes the mechanism of various droplet-based 3D bioprinting techniques and the most up-to-date applications in drug delivery and screening and discusses the potential improvements of droplet-based 3D bioprinting techniques from both technical and material aspects. Through technical innovations, materials development, and the assistance from artificial intelligence, the formation process of drug carriers will be more stable and accurately controlled guaranteeing precise drug delivery. Meanwhile, the shape fidelity and uniformity of the printed tissue models will be significantly improved ensuring drug screening efficiency and efficacy.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115486"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of pharmacometrics in drug development 药物计量学在药物开发中的应用

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115503

Yuan Xiong , Mahesh N. Samtani , Daniele Ouellet

{"title":"Applications of pharmacometrics in drug development","authors":"Yuan Xiong , Mahesh N. Samtani , Daniele Ouellet","doi":"10.1016/j.addr.2024.115503","DOIUrl":"10.1016/j.addr.2024.115503","url":null,"abstract":"<div><div>The last two decades have witnessed profound changes in how advanced computational tools can help leverage tons of data to improve our knowledge, and ultimately reduce cost and increase productivity in drug development. Pharmacometrics has demonstrated its impact through model-informed drug development (MIDD) approaches. It is now an indispensable component throughout the whole continuum of drug discovery, development, regulatory review, and approval. Today, applications of pharmacometrics are common in designing better trials and accelerating evidence-based decisions. Newly emerging technologies, especially those from data and computer sciences, are being integrated with existing computational tools used in the pharmaceutical industry at a remarkably fast pace. The new challenges faced by the pharmacometrics community are not what or how to contribute, but which optimal MIDD strategy should be adopted to maximize its value in the decision-making process. While we are embracing new innovative approaches and tools, this article discusses how a variety of existing modeling tools, with differentiated advantages and focus, can work in concert to inform drug development.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115503"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing tumor microenvironment and lymphoid tissue research through 3D bioprinting and biofabrication 通过生物3D打印和生物制造推进肿瘤微环境和淋巴组织的研究

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115485

Corrado Mazzaglia , Yan Yan Shery Huang , Jacqueline D. Shields

{"title":"Advancing tumor microenvironment and lymphoid tissue research through 3D bioprinting and biofabrication","authors":"Corrado Mazzaglia , Yan Yan Shery Huang , Jacqueline D. Shields","doi":"10.1016/j.addr.2024.115485","DOIUrl":"10.1016/j.addr.2024.115485","url":null,"abstract":"<div><div>Cancer progression is significantly influenced by the complex interactions within the tumor microenvironment (TME). Immune cells, in particular, play a critical role by infiltrating tumors from the circulation and surrounding lymphoid tissues in an attempt to control their spread. However, they often fail in this task. Current <em>in vivo</em> and <em>in vitro</em> preclinical models struggle to fully capture these intricate interactions affecting our ability to understand immune evasion and predict drugs behaviour in the clinic. To address this challenge, biofabrication and particularly 3D bioprinting has emerged as a promising tool for modeling both tumors and the immune system. Its ability to incorporate multiple cell types into 3D matrices, enable tissue compartmentalization with high spatial accuracy, and integrate vasculature makes it a valuable approach. Nevertheless, limited research has focused on capturing the complex tumor-immune interplay <em>in vitro</em>. This review highlights the composition and significance of the TME, the architecture and function of lymphoid tissues, and innovative approaches to modeling their interactions <em>in vitro</em>, while proposing the concept of an extended TME.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115485"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeing through the skin: Optical methods for visualizing transdermal drug delivery with microneedles 透过皮肤看世界：用光学方法观察微针透皮给药情况

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115478

Benchaphorn Limcharoen , Supason Wanichwecharungruang , Wijit Banlunara , Maxim E. Darvin

{"title":"Seeing through the skin: Optical methods for visualizing transdermal drug delivery with microneedles","authors":"Benchaphorn Limcharoen , Supason Wanichwecharungruang , Wijit Banlunara , Maxim E. Darvin","doi":"10.1016/j.addr.2024.115478","DOIUrl":"10.1016/j.addr.2024.115478","url":null,"abstract":"<div><div>Optical methods play a pivotal role in advancing transdermal drug delivery research, particularly with the emergence of microneedle technology. This review presents a comprehensive analysis of optical methods used in studying transdermal drug delivery facilitated by microneedle technology. Beginning with an introduction to microneedle technology and skin anatomy and optical properties, the review explores the integration of optical methods for enhanced visualization. Optical imaging offers key advantages including real-time drug distribution visualization, non-invasive skin response monitoring, and quantitative drug penetration analysis. A spectrum of optical imaging modalities ranging from conventional dermoscopy and stereomicroscopy to advance techniques as fluorescence microscopy, laser scanning microscopy, <em>in vivo</em> imaging system, two-photon microscopy, fluorescence lifetime imaging microscopy, optical coherence tomography, Raman microspectroscopy, laser speckle contrast imaging, and photoacoustic microscopy is discussed. Challenges such as resolution and depth penetration limitations are addressed alongside potential breakthroughs and future directions in optical techniques development. The review underscores the importance of bridging the gap between preclinical and clinical studies, explores opportunities for integrating optical imaging and chemical sensing methods with drug delivery systems, and highlight the importance of non-invasive “optical biopsy” as a valuable alternative to conventional histology. Overall, this review provides insight into the role of optical methods in understanding transdermal drug delivery mechanisms with microneedles.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115478"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Additive manufacturing in spatial patterning for spinal cord injury treatment 用于脊髓损伤治疗的空间模式的增材制造

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-27 DOI: 10.1016/j.addr.2025.115523

Christy Kwokdinata , Sing Yian Chew

{"title":"Additive manufacturing in spatial patterning for spinal cord injury treatment","authors":"Christy Kwokdinata , Sing Yian Chew","doi":"10.1016/j.addr.2025.115523","DOIUrl":"10.1016/j.addr.2025.115523","url":null,"abstract":"<div><div>Combinatorial treatments integrating cells and biomolecules within scaffolds have been investigated to address the multifactorial nature of spinal cord injury (SCI). Current regenerative treatments have been ineffective as they do not consider the spatial positions of various cell types to effectively form functional neural pathways. Emulating the complex heterogeneity of cells in the native spinal cord requires translating the existing biological understanding of spatial patterning in neural development, as well as the influence of biomolecule and mechanical patterning on regional specification and axonal regeneration, to engineer a scaffold for spinal cord regeneration. This review explores the potential of 3D bioprinting to precisely control material, cell and drug patterns in scaffolds, achieving spatial phenotype specification and providing axonal guidance to form appropriate connections. We also discuss the application of extrusion-based and digital light processing bioprinting in integrating mechanical, chemical and biological cues within a scaffold to advance spatially patterned 3D bioprinted scaffold, as well as current challenges and future perspectives in these bioengineering strategies.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"218 ","pages":"Article 115523"},"PeriodicalIF":15.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical perspective on pluripotent stem cells derived cell therapies for the treatment of neurodegenerative diseases 多能干细胞衍生细胞疗法治疗神经退行性疾病的临床前景

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-27 DOI: 10.1016/j.addr.2025.115525

Michal Izrael , Judith Chebath , Kfir Molakandov , Michel Revel

{"title":"Clinical perspective on pluripotent stem cells derived cell therapies for the treatment of neurodegenerative diseases","authors":"Michal Izrael , Judith Chebath , Kfir Molakandov , Michel Revel","doi":"10.1016/j.addr.2025.115525","DOIUrl":"10.1016/j.addr.2025.115525","url":null,"abstract":"<div><div>Self-renewal capacity and potential to differentiate into almost any cell type of the human body makes pluripotent stem cells a valuable starting material for manufacturing of clinical grade cell therapies. Neurodegenerative diseases are characterized by gradual loss of structure or function of neurons, often leading to neuronal death. This results in gradual decline of cognitive, motor, and physiological functions due to the degeneration of the central nervous systems. Over the past two decades, comprehensive preclinical efficacy (proof-of-concept) and safety studies have led to the initiation of First-in-Human phase I-II clinical trials for a range of neurodegenerative diseases. In this review, we explore the fundamentals and challenges of neural-cell therapies derived from pluripotent stem cells for treating neurodegenerative diseases. Additionally, we highlight key preclinical investigations that paved the way for regulatory approvals of these trials. Furthermore, we provide an overview on progress and status of clinical trials done so far in treating neurodegenerative diseases such as spinal cord injury (SCI), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), as well as advances in retina diseases such as Stargardt disease (a.k.a fundus flavimaculatus), retinitis pigmentosa (RP) and age-related macular degeneration (AMD). These trials will pave the way for the development of new cell-based therapies targeting additional neurological conditions, including Alzheimer’s disease and epilepsy.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"218 ","pages":"Article 115525"},"PeriodicalIF":15.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging 突破靶向治疗的障碍：推进外泌体分离、工程和成像

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-22 DOI: 10.1016/j.addr.2025.115522

Anastasiya Kostyusheva , Eugenia Romano , Neng Yan , Manu Lopus , Andrey A. Zamyatnin Jr. , Alessandro Parodi

{"title":"Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging","authors":"Anastasiya Kostyusheva , Eugenia Romano , Neng Yan , Manu Lopus , Andrey A. Zamyatnin Jr. , Alessandro Parodi","doi":"10.1016/j.addr.2025.115522","DOIUrl":"10.1016/j.addr.2025.115522","url":null,"abstract":"<div><div>Exosomes have emerged as promising tools for targeted drug delivery in biomedical applications and medicine. This review delves into the scientific advancements, challenges, and future prospects specifically associated with these technologies. In this work, we trace the research milestones that led to the discovery and characterization of exosomes and extracellular vesicles, and discuss strategies for optimizing the synthetic yield and the loading of these particles with various therapeutics. In addition, we report the current major issues affecting the field and hampering the clinical translation of these technologies. Highlighting the pivotal role of imaging techniques, we explore how they drive exosome therapy and development by offering insights into biodistribution and cellular trafficking dynamics. Methodologies for vesicle isolation, characterization, loading, and delivery mechanisms are thoroughly examined, alongside strategies aimed at enhancing their therapeutic efficacy. Special emphasis was dedicated to their therapeutic properties, particularly to their ability to deliver biologics into the cytoplasm. Furthermore, we delve into the intricate balance between surface modifications and targeting properties including also transgenic methods aimed at their functionalization and visualization within biological systems. This review underscores the transformative potential of these carriers in targeted drug delivery and identifies crucial areas for further research and clinical translation.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"218 ","pages":"Article 115522"},"PeriodicalIF":15.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0