Advanced drug delivery reviews最新文献

{"title":"Branched DNA for disease diagnosis and therapy","authors":"Junru Li ,&nbsp;Yongming Han ,&nbsp;Na Chen ,&nbsp;Wenzhi Yang ,&nbsp;Xiaohan Cai ,&nbsp;Siqi Tian ,&nbsp;Peipei Zhao ,&nbsp;Wenhao Zhang ,&nbsp;Dan Luo ,&nbsp;Guoqing Tang ,&nbsp;Fengqin Li ,&nbsp;Peifeng Liu","doi":"10.1016/j.addr.2025.115683","DOIUrl":"10.1016/j.addr.2025.115683","url":null,"abstract":"<div><div>DNA exhibits remarkable versatility, which is attributed to its inherent molecular recognition capabilities, programmable sequences, and excellent biocompatibility. Among its various topological forms, branched DNA (bDNA), including Y-shaped DNA (Y-DNA), X-shaped DNA (X-DNA), etc., stands out as a fundamental building block for fabricating functional DNA-based materials and has demonstrated great promise across diverse applications in recent years. Motivated by urgent demands in disease diagnosis and therapy, bDNA has developed into a rapidly advancing field. In this review, the design strategies for synthesizing monomers of bDNA and their assembly into complex functional materials are summarized. The pivotal role of bDNA in disease diagnostics is presented, emphasizing its utility in detecting disease-related biomarkers with high sensitivity and specificity. Additionally, we highlight the therapeutic applications of bDNA-based materials, such as hydrogels and microspheres, particularly in cancer treatment and the clinical translation of bDNA. Finally, the challenges and future directions for advancing bDNA technology in disease diagnosis and therapy are discussed, providing new insights into potential breakthroughs and their translational potential. These advances highlight the clinical translational potential of bDNA structures as powerful tools for disease diagnosis and treatment, offering promising avenues for improved disease detection and personalized therapy.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"226 ","pages":"Article 115683"},"PeriodicalIF":17.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aptamers as target-specific recognition elements in drug delivery","authors":"Agbor Otu Egbe Vydaline ,&nbsp;Sergei Rozhkov ,&nbsp;German Sosa ,&nbsp;Prabodhika Mallikaratchy","doi":"10.1016/j.addr.2025.115685","DOIUrl":"10.1016/j.addr.2025.115685","url":null,"abstract":"<div><div>Targeted drug delivery significantly enhances therapeutic efficacy across various diseases, particularly in cancer treatments, where conventional approaches such as chemotherapy and radiotherapy often cause severe side effects. In this context, nucleic acid aptamers—short, single-stranded DNA or RNA oligonucleotides capable of binding specific targets with high affinity—have emerged as promising tools for precision drug delivery and therapy. Aptamers can be selected against whole, living cells using SELEX and chemically modified for diverse applications. Their chemical versatility and specific binding capabilities allow aptamers to be engineered into aptamer-drug conjugates, nanoparticles, DNA origami structures, and bi-/multivalent or bispecific constructs. These platforms enable selective recognition of unique molecular signatures on cells or small molecules, facilitating highly targeted drug delivery and controlled release at the disease site. Such precision reduces systemic toxicity and enhances therapeutic outcomes. Compared to antibodies, aptamers offer several advantages, including faster tissue penetration, lower immunogenicity, greater chemical stability, and improved bioavailability in vivo. This review highlights recent advances in aptamer modification strategies—both covalent and non-covalent—for conjugation with chemotherapeutic agents, gold nanoparticles (GNPs), and photosensitizers. We further assess their potential as drug delivery vehicles and therapeutic agents and discuss how these innovations are driving progress in precision medicine.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"226 ","pages":"Article 115685"},"PeriodicalIF":17.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design principles for construction of DNA-based nanostructures","authors":"Chunfa Chen ,&nbsp;Xiaoyu Xia ,&nbsp;Cheng Tian ,&nbsp;Zhe Zhang ,&nbsp;Jin Jin ,&nbsp;Cheng Zhi Huang ,&nbsp;Hua Zuo ,&nbsp;Chengde Mao","doi":"10.1016/j.addr.2025.115679","DOIUrl":"10.1016/j.addr.2025.115679","url":null,"abstract":"<div><div>DNA nanotechnology, a cutting-edge field that constructs sophisticated DNA-based nanostructures by harnessing the unparalleled programmability of DNA, has evolved into a powerful tool for applications in therapy, biosensing, logic computation, and more. This review outlines the fundamental strategies for constructing DNA nanostructures, beginning with the design of basic building blocks such as small, symmetric tiles (e.g., DX and TX tiles, point star motifs, T-junctions), and extending to more complex, addressable scaffolds like DNA origami and single-stranded tile (SST) structures. Furthermore, it surveys extended arrays (1D/2D arrays, nanotubes, 3D crystals) formed through motif association, while introducing the computational potential of algorithmic self-assembly and the properties of DNA-based aggregates (hydrogels, liquid–liquid phase separation systems). The design and construction logic of DNA nanostructures, spanning from static to dynamic systems and from microscopic to macroscopic scales, is also elucidated.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"226 ","pages":"Article 115679"},"PeriodicalIF":17.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in intelligent oxygen delivery systems for tissue regeneration","authors":"Xuehui Rui ,&nbsp;Yiyang Jia ,&nbsp;Ruochen Qiao ,&nbsp;Xiaoting Peng ,&nbsp;Yuchen Wang ,&nbsp;Tao Li ,&nbsp;Chuan Zhao ,&nbsp;Jinhui Wu","doi":"10.1016/j.addr.2025.115684","DOIUrl":"10.1016/j.addr.2025.115684","url":null,"abstract":"<div><div>Oxygen plays a critical regulatory role in tissue repair and regeneration. However, in the microenvironment of tissues with vascular damage, hypoxia is commonly present. This not only suppresses cell proliferation and differentiation but also delays angiogenesis and extracellular matrix reconstruction, ultimately hindering the tissue regeneration process. Therefore, developing oxygen delivery strategies that can effectively enhance local oxygen levels has become one of the key approaches to promoting tissue regeneration. Traditional oxygen delivery strategies for tissue regeneration face several challenges, including inadequate sustained oxygen supply, poor targeting ability, and limited biocompatibility. To address these limitations, researchers have developed a variety of “intelligent oxygen delivery systems.” These systems can dynamically regulate oxygen release and achieve tissue-specific targeted delivery by responding to environmental or external stimuli, thereby significantly improving the precision and efficacy of oxygen therapy. This review systematically summarizes the biological functions of oxygen in tissue regeneration, with a particular focus on intelligent strategies for oxygen generation and supply developed in recent years. In addition, this review discusses the oxygen generation mechanisms, release kinetics, biocompatibility, application potential, and limitations of various oxygen delivery strategies. Finally, the review emphasizes that future designs of oxygen delivery systems should place greater emphasis on intelligent regulation, aiming to facilitate their clinical translation in tissue regeneration-related diseases such as chronic wounds, bone repair, and myocardial infarction.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"226 ","pages":"Article 115684"},"PeriodicalIF":17.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and opportunities on achieving an adequate delivery efficiency and immunogenicity with peptide-based anticancer vaccines","authors":"Yanqing Wang ,&nbsp;Da Sun ,&nbsp;Victoria Laney ,&nbsp;Hong Wang ,&nbsp;Li Lily Wang ,&nbsp;Zheng-Rong Lu","doi":"10.1016/j.addr.2025.115675","DOIUrl":"10.1016/j.addr.2025.115675","url":null,"abstract":"<div><div>Peptide vaccines are based on small peptide segments that contain antigenic epitopes recognizable by immune cells. Unlike traditional vaccines, they include only specific antigenic epitopes rather than entire pathogens or proteins. They are recognized, internalized, processed, and presented by antigen-presenting cells, such as dendritic cells, and subsequently presented to T cells, triggering an immune response. Peptide-based vaccines, an innovative regimen of cancer immunotherapy, have shown the potential to elicit target-specific anti-tumor immune responses, however their therapeutic efficacy is often diminished by their poor stability, rapid clearance from circulation, low immunogenicity, individual variability, and immune escape. In recent years, significant advancements have been achieved in the mechanism of action, design, and delivery of potent peptide-based cancer vaccines to address their limitations for clinical translation. Long peptide vaccines are more likely to induce antigen cross-presentation than short peptide vaccines. Tumor-specific peptide antigens and tumor-associated antigens have been developed to enhance anti-cancer immunogenicity. Incorporation of various delivery systems, such as lipid nanoparticles, polymers, and viral vectors substantially improve the stability of peptide antigens in circulation. Co-delivery of the peptide antigens and adjuvants further enhances with antigen presentation and T-cell activation, resulting in robust immunogenicity and efficacious cancer immunotherapy. Combination therapy of peptide vaccines and other therapies, including chemotherapy, radiotherapy, immune checkpoint inhibitors, and targeted therapy also enhances therapeutic outcomes. This article provides insights in cancer peptide vaccines, including the mechanism of action of peptide antigens and adjuvants, while discussing their challenges and opportunities, and exploring the use of delivery systems to improve their pharmacokinetics and therapeutic efficacies for cancer immunotherapy.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"225 ","pages":"Article 115675"},"PeriodicalIF":17.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA nanotechnology in oligonucleotide drug delivery systems: Prospects for Bio-nanorobots in cancer treatment","authors":"Haniyeh Abdollahzadeh ,&nbsp;Tonya L. Peeples ,&nbsp;Mohammad Shahcheraghi","doi":"10.1016/j.addr.2025.115673","DOIUrl":"10.1016/j.addr.2025.115673","url":null,"abstract":"<div><div>DNA-based nanomaterials have demonstrated significant potential in various applications due to their unique properties, including DNA’s diverse molecular interactions, programmability, and versatility with biological modules. Meanwhile, the DNA origami platforms have shown promise in the creation of drug carriers. This technique has paved the way for the production of nanomachines with outstanding performance. Moreover, DNA’s encoding capability and its massive parallelism help us to manipulate it for DNA computation. The DNA nanotechnology method holds potential, particularly for oligonucleotide therapeutics that enable precision medicine for cancers.</div><div>In this review, we explore the potential of DNA nanotechnology in this context, focusing on the DNA origami method and its production challenges, and proposing streamlined methods to enhance scalability and efficiency by enzymatic tools in life-like artificial systems. We then delve into studies demonstrating the application of DNA nanotechnology in delivering oligonucleotide drugs for tumor targeting. Following this, we assess DNA-based dynamic nanodevices that can be activated through molecular binding, environmental stimuli, and external field manipulation. Subsequently, we investigate the significance of DNA computation in the production of logic gates, DNA circuits, data storage, and machine learning, along with its role in drug delivery approaches.</div><div>By systematically classifying DNA robots according to their fundamental operating mechanisms, Machinery DNA Robots (MDNARs) and Computational DNA Robots (CDNARs), we pave the way for next-generation ’Bio-nanorobots.’ These advanced systems can integrate DNA computation with dynamic DNA machinery to enable precision cancer therapeutics through intelligent molecular-scale operations.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"225 ","pages":"Article 115673"},"PeriodicalIF":17.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-scale metabolic modelling in antimicrobial pharmacology: Present and future","authors":"Jianjun Tao ,&nbsp;Yu-Wei Lin ,&nbsp;Lingyuxiu Zhong ,&nbsp;Yan Zhu ,&nbsp;Xinpeng Yao ,&nbsp;Michael Aichem ,&nbsp;Falk Schreiber ,&nbsp;Jinxin Zhao ,&nbsp;Jian Li","doi":"10.1016/j.addr.2025.115672","DOIUrl":"10.1016/j.addr.2025.115672","url":null,"abstract":"<div><div>The persistent surge in antimicrobial resistance (AMR) has propelled the search for innovative strategies in antimicrobial use. Genome-scale metabolic modelling (GSMM) has emerged as a transformative tool in this quest, offering a comprehensive understanding of host and microbial metabolism and their interactions with antimicrobial agents. This review emphasises current advancements in the application of GSMM to antimicrobial pharmacology, highlighting its role in deciphering complex microbial and host responses to drug exposure, identifying novel therapeutic targets and optimising therapeutic options. We discuss how GSMM has elucidated mechanisms of drug action, resistance pathways, and off-target effects, providing a systems-level perspective that challenges the traditional “one drug, one target” approach. The integration of GSMM with high-throughput omics technologies and machine learning showcases its potential to refine predictions of drug efficacy, optimise dosing strategies, and minimise toxicity. We also address the challenges and future directions of GSMM, including its expansion to host-pathogen-drug interactions and personalised medicine. Ultimately, GSMM stands as a critical approach in modern antimicrobial research, with the potential to revolutionise the development of effective treatments against MDR pathogens.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"225 ","pages":"Article 115672"},"PeriodicalIF":17.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA-based nanostructures for cell membrane receptor regulation and disease treatment","authors":"Zhongyu Cheng ,&nbsp;Yanfei Liu ,&nbsp;Qiwen Chen ,&nbsp;Yifu Tan ,&nbsp;Yunqi Man ,&nbsp;Zhirou Zhang ,&nbsp;Shuqing Du ,&nbsp;Zexiang Lv ,&nbsp;Qian Wang ,&nbsp;Kan Shao ,&nbsp;Zhenbao Liu","doi":"10.1016/j.addr.2025.115674","DOIUrl":"10.1016/j.addr.2025.115674","url":null,"abstract":"<div><div>The aberrant expression and dysfunction of cell membrane receptors are closely associated with the onset and progression of various major diseases, such as cancer, neurodegenerative disorders, and inflammation. However, conventional membrane protein regulation strategies, such as small-molecule inhibitors or antibody-based therapies, face several challenges, including target dependency, limited degradation scope, and the development of drug resistance. In recent years, DNA nanostructure has emerged as an innovative solution for the precise modulation of membrane receptors, owing to its high programmability, precise spatial control, and dynamic responsiveness. This review provides a comprehensive overview of the design strategies and recent progress in the application of DNA nanostructures for membrane protein regulation, with a particular emphasis on their pivotal roles in spatial blockade, spatial reorganization, and targeted degradation of membrane receptors. By rationally designing DNA origami, aptamer-based nanoarrays, and dynamic responsive devices, researchers have achieved precise control over receptor dimerization, oligomerization, and membrane compartmentalization, thereby modulating downstream signaling pathways. In addition, DNA nano-degradation platforms based on proteolysis-targeting chimeras (PROTACs), lysosome-targeting chimeras (LYTACs), and the autophagy-lysosome pathway have significantly enhanced the efficiency of membrane protein degradation while demonstrating excellent tumor selectivity. DNA nanostructures have been successfully applied in cancer immunotherapy, interventions for neurodegenerative diseases, and the regulation of metabolic disorders, offering new strategies for targeting previously “undruggable” proteins. This review highlights recent breakthroughs in the field and outlines future directions and clinical translation potential of DNA nanostructures for membrane protein regulation.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"225 ","pages":"Article 115674"},"PeriodicalIF":17.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classic versus innovative strategies for immuno-therapy in pancreatic cancer","authors":"Maria Giovanna Formelli ,&nbsp;Andrea Palloni ,&nbsp;Simona Tavolari ,&nbsp;Chiara Deiana ,&nbsp;Elisa Andrini ,&nbsp;Mariacristina Di Marco ,&nbsp;Davide Campana ,&nbsp;Giuseppe Lamberti ,&nbsp;Giovanni Brandi","doi":"10.1016/j.addr.2025.115671","DOIUrl":"10.1016/j.addr.2025.115671","url":null,"abstract":"<div><div>Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a dismal prognosis. Immunotherapy with immune checkpoint inhibitors (ICIs), either as monotherapy, in combination with other ICIs, or alongside chemotherapy, has significantly improved outcomes in several solid tumors. However, its efficacy in PDAC remains limited due to multiple resistance mechanisms.</div><div>Key determinants of immunotherapy resistance in PDAC include physical barriers that hinder immune cells infiltration, such as aberrant vasculature, cancer-associated fibroblasts (CAFs), and excessive hyaluronic acid deposition in the tumor microenvironment (TME). Additionally, PDAC is characterized by an immunosuppressive TME enriched with regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and by low immunogenicity of tumor cells due to KRAS mutations, MYC overexpression, and a low tumor mutational burden, further impairing antitumor immunity.</div><div>This review discusses advanced drug delivery systems to overcome determinants of immunotherapy resistance and to improve outcomes, explores emerging immunotherapy strategies, including adoptive cell therapies, cancer vaccines, and the potential role of microbiota as modulator of TME through fecal microbiota transplantation or intratumoral bacterial inoculation. Given the ambivalent role of microbiota in PDAC, the need for a clear definition of favorable strains and their selection is highlighted. Emerging approaches involving engineered bacteria and artificial intelligence applications are also explored.</div><div>Finally, we propose a hypothetical conceptual framework for an innovative multimodal immunotherapy approach to overcome resistance and improve clinical outcomes in PDAC.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"225 ","pages":"Article 115671"},"PeriodicalIF":17.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards airway microbiome engineering for improving respiratory health.","authors":"Kelsey E Hern, Arthur Prindle","doi":"10.1016/j.addr.2025.115662","DOIUrl":"10.1016/j.addr.2025.115662","url":null,"abstract":"<p><p>The known roles of human-associated microbes in health and disease have expanded in recent years. While the gut microbiome is the most well studied, the airway microbiome is gaining attention as an important gatekeeper of respiratory health. Compared to the gut, the airway microbiome has lower species complexity, greater niche stability, and represents an immediate point of contact with the outside world. These features make it an attractive target for improving respiratory health. As respiratory disease continues to increase among humans, it will be critical to develop novel approaches to combat new and emergent bacterial infections, viruses, and cancers for which we do not currently have treatments. This review seeks to define strategies for airway microbiome engineering-the intentional manipulation of airway associated microbes to restore species balance, enhance protective functions, or treat disease. We summarize the growing body of literature linking the airway microbiome to respiratory health and discuss both broad-spectrum and high precision technologies that hold particular promise for further development. We argue that inhaled probiotics and bacteriophage are among the most attractive technologies for clinical translation of airway microbiome engineering to improve respiratory health.</p>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":" ","pages":"115662"},"PeriodicalIF":21.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}