Advanced drug delivery reviews最新文献_第8页

Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads 探索细胞衍生囊泡瞬时传递基因编辑有效载荷的潜力。

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-06-06 DOI: 10.1016/j.addr.2024.115346

Kevin Leandro , David Rufino-Ramos , Koen Breyne , Emilio Di Ianni , Sara M. Lopes , Rui Jorge Nobre , Benjamin P. Kleinstiver , Pedro R.L. Perdigão , Xandra O. Breakefield , Luís Pereira de Almeida

{"title":"Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads","authors":"Kevin Leandro , David Rufino-Ramos , Koen Breyne , Emilio Di Ianni , Sara M. Lopes , Rui Jorge Nobre , Benjamin P. Kleinstiver , Pedro R.L. Perdigão , Xandra O. Breakefield , Luís Pereira de Almeida","doi":"10.1016/j.addr.2024.115346","DOIUrl":"10.1016/j.addr.2024.115346","url":null,"abstract":"<div><p>Gene editing technologies have the potential to correct genetic disorders by modifying, inserting, or deleting specific DNA sequences or genes, paving the way for a new class of genetic therapies. While gene editing tools continue to be improved to increase their precision and efficiency, the limited efficacy of <em>in vivo</em> delivery remains a major hurdle for clinical use. An ideal delivery vehicle should be able to target a sufficient number of diseased cells in a transient time window to maximize on-target editing and mitigate off-target events and immunogenicity.</p><p>Here, we review major advances in novel delivery platforms based on cell-derived vesicles − extracellular vesicles and virus-like particles − for transient delivery of gene editing payloads. We discuss major findings regarding packaging, <em>in vivo</em> biodistribution, therapeutic efficacy, and safety concerns of cell-derived vesicles delivery of gene editing cargos and their potential for clinical translation.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"211 ","pages":"Article 115346"},"PeriodicalIF":15.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141287593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo deposition of poorly soluble drugs 难溶性药物的体内沉积。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-06-06 DOI: 10.1016/j.addr.2024.115358

Zhaohuan Lou , Chaofeng Mu , Clairissa D. Corpstein , Tonglei Li

{"title":"In vivo deposition of poorly soluble drugs","authors":"Zhaohuan Lou , Chaofeng Mu , Clairissa D. Corpstein , Tonglei Li","doi":"10.1016/j.addr.2024.115358","DOIUrl":"10.1016/j.addr.2024.115358","url":null,"abstract":"<div><p>Administered drug molecules, whether dissolved or solubilized, have the potential to precipitate and accumulate as solid forms in tissues and cells within the body. This phase transition can significantly impact the pharmacokinetics of treatment. It is thus crucial to gain an understanding of how drug solubility/permeability, drug formulations and routes of administration affect <em>in vivo</em> behaviors of drug deposition. This review examines literature reports on the drug deposition in tissues and cells of poorly water-soluble drugs, as well as underlying physical mechanisms that lead to precipitation. Our work particularly highlights drug deposition in macrophages and the subcellular fate of precipitated drugs. We also propose a tissue permeability-based classification framework to evaluate precipitation potentials of poorly soluble drugs in major organs and tissues. The impact on pharmacokinetics is further discussed and needs to be considered in developing drug delivery systems. Finally, bioimaging techniques that are used to examine aggregated states and the intracellular trafficking of absorbed drugs are summarized.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"211 ","pages":"Article 115358"},"PeriodicalIF":16.1,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery 用于线粒体靶向基因递送的线粒体内源性物质转运纳米材料。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-06-05 DOI: 10.1016/j.addr.2024.115355

Yi Wang , Jing-Song Yang , Min Zhao , Jia-Qi Chen , Hai-Xin Xie , Hao-Yuan Yu , Na-Hui Liu , Zi-Juan Yi , Hui-Lin Liang , Lei Xing , Hu-Lin Jiang

{"title":"Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery","authors":"Yi Wang , Jing-Song Yang , Min Zhao , Jia-Qi Chen , Hai-Xin Xie , Hao-Yuan Yu , Na-Hui Liu , Zi-Juan Yi , Hui-Lin Liang , Lei Xing , Hu-Lin Jiang","doi":"10.1016/j.addr.2024.115355","DOIUrl":"10.1016/j.addr.2024.115355","url":null,"abstract":"<div><p>Mitochondrial genome (mtDNA) independent of nuclear gene is a set of double-stranded circular DNA that encodes 13 proteins, 2 ribosomal RNAs and 22 mitochondrial transfer RNAs, all of which play vital roles in functions as well as behaviors of mitochondria. Mutations in mtDNA result in various mitochondrial disorders without available cures. However, the manipulation of mtDNA via the mitochondria-targeted gene delivery faces formidable barriers, particularly owing to the mitochondrial double membrane. Given the fact that there are various transport channels on the mitochondrial membrane used to transfer a variety of endogenous substances to maintain the normal functions of mitochondria, mitochondrial endogenous substance transport-inspired nanomaterials have been proposed for mitochondria-targeted gene delivery. In this review, we summarize mitochondria-targeted gene delivery systems based on different mitochondrial endogenous substance transport pathways. These are categorized into mitochondrial steroid hormones import pathways-inspired nanomaterials, protein import pathways-inspired nanomaterials and other mitochondria-targeted gene delivery nanomaterials. We also review the applications and challenges involved in current mitochondrial gene editing systems. This review delves into the approaches of mitochondria-targeted gene delivery, providing details on the design of mitochondria-targeted delivery systems and the limitations regarding the various technologies. Despite the progress in this field is currently slow, the ongoing exploration of mitochondrial endogenous substance transport and mitochondrial biological phenomena may act as a crucial breakthrough in the targeted delivery of gene into mitochondria and even the manipulation of mtDNA.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"211 ","pages":"Article 115355"},"PeriodicalIF":16.1,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141287594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances, challenges, and future directions in the clinical translation of ECM biomaterials for regenerative medicine applications 再生医学应用中 ECM 生物材料临床转化的进展、挑战和未来方向。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-06-04 DOI: 10.1016/j.addr.2024.115347

Héctor Capella-Monsonís , Raphael J. Crum , George S. Hussey , Stephen F. Badylak

{"title":"Advances, challenges, and future directions in the clinical translation of ECM biomaterials for regenerative medicine applications","authors":"Héctor Capella-Monsonís , Raphael J. Crum , George S. Hussey , Stephen F. Badylak","doi":"10.1016/j.addr.2024.115347","DOIUrl":"10.1016/j.addr.2024.115347","url":null,"abstract":"<div><p>Extracellular Matrix (ECM) scaffolds and biomaterials have been widely used for decades across a variety of diverse clinical applications and have been implanted in millions of patients worldwide. ECM-based biomaterials have been especially successful in soft tissue repair applications but their utility in other clinical applications such as for regeneration of bone or neural tissue is less well understood. The beneficial healing outcome with the use of ECM biomaterials is the result of their biocompatibility, their biophysical properties and their ability to modify cell behavior after injury. As a consequence of successful clinical outcomes, there has been motivation for the development of next-generation formulations of ECM materials ranging from hydrogels, bioinks, powders, to whole organ or tissue scaffolds. The continued development of novel ECM formulations as well as active research interest in these materials ensures a wealth of possibilities for future clinical translation and innovation in regenerative medicine. The clinical translation of next generation formulations ECM scaffolds faces predictable challenges such as manufacturing, manageable regulatory pathways, surgical implantation, and the cost required to address these challenges. The current status of ECM-based biomaterials, including clinical translation, novel formulations and therapies currently under development, and the challenges that limit clinical translation of ECM biomaterials are reviewed herein.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"211 ","pages":"Article 115347"},"PeriodicalIF":16.1,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141282669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria 针对肿瘤中的细菌代谢物进行癌症治疗：针对肿瘤相关细菌的另一种方法

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-06-02 DOI: 10.1016/j.addr.2024.115345

Guofeng Ji , Jingjing Zhao , Xinghui Si , Wantong Song

{"title":"Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria","authors":"Guofeng Ji , Jingjing Zhao , Xinghui Si , Wantong Song","doi":"10.1016/j.addr.2024.115345","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115345","url":null,"abstract":"<div><p>Emerging evidence reveal that tumor-associated bacteria (TAB) can facilitate the initiation and progression of multiple types of cancer. Recent work has emphasized the significant role of intestinal microbiota, particularly bacteria, plays in affecting responses to chemo- and immuno-therapies. Hence, it seems feasible to improve cancer treatment outcomes by targeting intestinal bacteria. While considering variable richness of the intestinal microbiota and diverse components among individuals, direct manipulating the gut microbiota is complicated in clinic. Tumor initiation and progression requires the gut microbiota-derived metabolites to contact and reprogram neoplastic cells. Hence, directly targeting tumor-associated bacteria metabolites may have the potential to provide alternative and innovative strategies to bypass the gut microbiota for cancer therapy. As such, there are great opportunities to explore holistic approaches that incorporates TAB-derived metabolites and related metabolic signals modulation for cancer therapy. In this review, we will focus on key opportunistic areas by targeting TAB-derived metabolites and related metabolic signals, but not bacteria itself, for cancer treatment, and elucidate future challenges that need to be addressed in this emerging field.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"211 ","pages":"Article 115345"},"PeriodicalIF":16.1,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiscale engineering of brain organoids for disease modeling 用于疾病建模的多尺度脑器官工程。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-05-27 DOI: 10.1016/j.addr.2024.115344

Cong Xu , Alia Alameri , Wei Leong , Emily Johnson , Zaozao Chen , Bin Xu , Kam W. Leong

引用次数: 0

A comprehensive comparison of DNA and RNA vaccines DNA 和 RNA 疫苗的综合比较。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-05-27 DOI: 10.1016/j.addr.2024.115340

Chunxi Wang, Fan Yuan

引用次数: 0

Modulating the immune system towards a functional chronic wound healing: A biomaterials and Nanomedicine perspective 调节免疫系统，实现功能性慢性伤口愈合：生物材料与纳米医学的视角

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-05-24 DOI: 10.1016/j.addr.2024.115342

Kevin Las Heras , Itxaso Garcia-Orue , Fiorenza Rancan , Manoli Igartua , Edorta Santos-Vizcaino , Rosa Maria Hernandez

{"title":"Modulating the immune system towards a functional chronic wound healing: A biomaterials and Nanomedicine perspective","authors":"Kevin Las Heras , Itxaso Garcia-Orue , Fiorenza Rancan , Manoli Igartua , Edorta Santos-Vizcaino , Rosa Maria Hernandez","doi":"10.1016/j.addr.2024.115342","DOIUrl":"10.1016/j.addr.2024.115342","url":null,"abstract":"<div><p>Chronic non-healing wounds persist as a substantial burden for healthcare systems, influenced by factors such as aging, diabetes, and obesity. In contrast to the traditionally pro-regenerative emphasis of therapies, the recognition of the immune system integral role in wound healing has significantly grown, instigating an approach shift towards immunological processes. Thus, this review explores the wound healing process, highlighting the engagement of the immune system, and delving into the behaviors of innate and adaptive immune cells in chronic wound scenarios. Moreover, the article investigates biomaterial-based strategies for the modulation of the immune system, elucidating how the adjustment of their physicochemical properties or their synergistic combination with other agents such as drugs, proteins or mesenchymal stromal cells can effectively modulate the behaviors of different immune cells. Finally this review explores various strategies based on synthetic and biological nanostructures, including extracellular vesicles, to finely tune the immune system as natural immunomodulators or therapeutic nanocarriers with promising biophysical properties.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"210 ","pages":"Article 115342"},"PeriodicalIF":16.1,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0169409X24001649/pdfft?md5=89e39d8cadbc6da6d3b51f030b927790&pid=1-s2.0-S0169409X24001649-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141131401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art 整合微针和传感策略，用于诊断和监测应用：最新技术

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-05-24 DOI: 10.1016/j.addr.2024.115341

Shihao Pei , Samuel Babity , Ana Sara Cordeiro , Davide Brambilla

引用次数: 0

Pathogenic fungi: Novel targets and theranostic strategies 致病真菌：新靶标和治疗策略。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-05-21 DOI: 10.1016/j.addr.2024.115343

Yue Wang, Linqi Wang, Chong Li

引用次数: 0