Advanced drug delivery reviews最新文献_第9页

Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system 用于向中枢和外周神经系统输送超声波调节药物的微型治疗系统。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-03-03 DOI: 10.1016/j.addr.2024.115275

Pancheng Zhu , Ignasi Simon , Ida Kokalari , Daniel S. Kohane , Alina Y. Rwei

引用次数: 0

Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release 纳米载体可消除细胞内障碍，实现高效给药、克服耐药性、亚细胞靶向和控制释放。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-03-02 DOI: 10.1016/j.addr.2024.115239

Jing Liu , Horacio Cabral , Peng Mi

{"title":"Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release","authors":"Jing Liu , Horacio Cabral , Peng Mi","doi":"10.1016/j.addr.2024.115239","DOIUrl":"10.1016/j.addr.2024.115239","url":null,"abstract":"<div><p>The cellular barriers are major bottlenecks for bioactive compounds entering into cells to accomplish their biological functions, which limits their biomedical applications. Nanocarriers have demonstrated high potential and benefits for encapsulating bioactive compounds and efficiently delivering them into target cells by overcoming a cascade of intracellular barriers to achieve desirable therapeutic and diagnostic effects. In this review, we introduce the cellular barriers ahead of drug delivery and nanocarriers, as well as summarize recent advances and strategies of nanocarriers for increasing internalization with cells, promoting intracellular trafficking, overcoming drug resistance, targeting subcellular locations and controlled drug release. Lastly, the future perspectives of nanocarriers for intracellular drug delivery are discussed, which mainly focus on potential challenges and future directions. Our review presents an overview of intracellular drug delivery by nanocarriers, which may encourage the future development of nanocarriers for efficient and precision drug delivery into a wide range of cells and subcellular targets.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115239"},"PeriodicalIF":16.1,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bringing innovative wound care polymer materials to the market: Challenges, developments, and new trends 将创新的伤口护理聚合物材料推向市场：挑战、发展和新趋势。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-27 DOI: 10.1016/j.addr.2024.115217

Pegah Sanjarnia , Matías L. Picchio , Agustin N. Polegre Solis , Katharina Schuhladen , Patricia M. Fliss , Nikolaos Politakos , Lutz Metterhausen , Marcelo Calderón , Ernesto R. Osorio-Blanco

{"title":"Bringing innovative wound care polymer materials to the market: Challenges, developments, and new trends","authors":"Pegah Sanjarnia , Matías L. Picchio , Agustin N. Polegre Solis , Katharina Schuhladen , Patricia M. Fliss , Nikolaos Politakos , Lutz Metterhausen , Marcelo Calderón , Ernesto R. Osorio-Blanco","doi":"10.1016/j.addr.2024.115217","DOIUrl":"10.1016/j.addr.2024.115217","url":null,"abstract":"<div><p>The development of innovative products for treating acute and chronic wounds has become a significant topic in healthcare, resulting in numerous products and innovations over time. The growing number of patients with comorbidities and chronic diseases, which may significantly alter, delay, or inhibit normal wound healing, has introduced considerable new challenges into the wound management scenario. Researchers in academia have quickly identified promising solutions, and many advanced wound healing materials have recently been designed; however, their successful translation to the market remains highly complex and unlikely without the contribution of industry experts. This review article condenses the main aspects of wound healing applications that will serve as a practical guide for researchers working in academia and industry devoted to designing, evaluating, validating, and translating polymer wound care materials to the market. The article highlights the current challenges in wound management, describes the state-of-the-art products already on the market and trending polymer materials, describes the regulation pathways for approval, discusses current wound healing models, and offers a perspective on new technologies that could soon reach consumers. We envision that this comprehensive review will significantly contribute to highlighting the importance of networking and exchanges between academia and healthcare companies. Only through the joint of these two actors, where innovation, manufacturing, regulatory insights, and financial resources act in harmony, can wound care products be developed efficiently to reach patients quickly and affordably.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115217"},"PeriodicalIF":16.1,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems 利用药物输送系统解决神经发育障碍中的髓鞘缺陷问题。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-24 DOI: 10.1016/j.addr.2024.115218

May Rokach , Corinne Portioli , Sayanti Brahmachari , Bianca Martins Estevão , Paolo Decuzzi , Boaz Barak

{"title":"Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems","authors":"May Rokach , Corinne Portioli , Sayanti Brahmachari , Bianca Martins Estevão , Paolo Decuzzi , Boaz Barak","doi":"10.1016/j.addr.2024.115218","DOIUrl":"10.1016/j.addr.2024.115218","url":null,"abstract":"<div><p>Interest in myelin and its roles in almost all brain functions has been greatly increasing in recent years, leading to countless new studies on myelination, as a dominant process in the development of cognitive functions. Here, we explore the unique role myelin plays in the central nervous system and specifically discuss the results of altered myelination in neurodevelopmental disorders. We present parallel developmental trajectories involving myelination that correlate with the onset of cognitive impairment in neurodevelopmental disorders and discuss the key challenges in the treatment of these chronic disorders. Recent developments in drug repurposing and nano/micro particle-based therapies are reviewed as a possible pathway to circumvent some of the main hurdles associated with early intervention, including patient’s adherence and compliance, side effects, relapse, and faster route to possible treatment of these disorders. The strategy of drug encapsulation overcomes drug solubility and metabolism, with the possibility of drug targeting to a specific compartment, reducing side effects upon systemic administration.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115218"},"PeriodicalIF":16.1,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139970618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-viral delivery of RNA for therapeutic T cell engineering 用于治疗性 T 细胞工程的非病毒 RNA 运送技术

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-23 DOI: 10.1016/j.addr.2024.115215

Dominika Berdecka , Stefaan C. De Smedt , Winnok H. De Vos , Kevin Braeckmans

{"title":"Non-viral delivery of RNA for therapeutic T cell engineering","authors":"Dominika Berdecka , Stefaan C. De Smedt , Winnok H. De Vos , Kevin Braeckmans","doi":"10.1016/j.addr.2024.115215","DOIUrl":"10.1016/j.addr.2024.115215","url":null,"abstract":"<div><p>Adoptive T cell transfer has shown great success in treating blood cancers, resulting in a growing number of FDA-approved therapies using chimeric antigen receptor (CAR)-engineered T cells. However, the effectiveness of this treatment for solid tumors is still not satisfactory, emphasizing the need for improved T cell engineering strategies and combination approaches. Currently, CAR T cells are mainly manufactured using gammaretroviral and lentiviral vectors due to their high transduction efficiency. However, there are concerns about their safety, the high cost of producing them in compliance with current Good Manufacturing Practices (cGMP), regulatory obstacles, and limited cargo capacity, which limit the broader use of engineered T cell therapies. To overcome these limitations, researchers have explored non-viral approaches, such as membrane permeabilization and carrier-mediated methods, as more versatile and sustainable alternatives for next-generation T cell engineering. Non-viral delivery methods can be designed to transport a wide range of molecules, including RNA, which allows for more controlled and safe modulation of T cell phenotype and function. In this review, we provide an overview of non-viral RNA delivery in adoptive T cell therapy. We first define the different types of RNA therapeutics, highlighting recent advancements in manufacturing for their therapeutic use. We then discuss the challenges associated with achieving effective RNA delivery in T cells. Next, we provide an overview of current and emerging technologies for delivering RNA into T cells. Finally, we discuss ongoing preclinical and clinical studies involving RNA-modified T cells.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"208 ","pages":"Article 115215"},"PeriodicalIF":16.1,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139943292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactions between nanoparticles and pathological changes of vascular in Alzheimer’s disease 纳米粒子与阿尔茨海默病血管病理变化之间的相互作用

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-23 DOI: 10.1016/j.addr.2024.115219

Ting Lei , Zixiao Yang , Hanmei Li , Meng Qin , Huile Gao

{"title":"Interactions between nanoparticles and pathological changes of vascular in Alzheimer’s disease","authors":"Ting Lei , Zixiao Yang , Hanmei Li , Meng Qin , Huile Gao","doi":"10.1016/j.addr.2024.115219","DOIUrl":"10.1016/j.addr.2024.115219","url":null,"abstract":"<div><p>Emerging evidence suggests that vascular pathological changes play a pivotal role in the pathogenesis of Alzheimer's disease (AD). The dysfunction of the cerebral vasculature occurs in the early course of AD, characterized by alterations in vascular morphology, diminished cerebral blood flow (CBF), impairment of the neurovascular unit (NVU), vasculature inflammation, and cerebral amyloid angiopathy. Vascular dysfunction not only facilitates the influx of neurotoxic substances into the brain, triggering inflammation and immune responses but also hampers the efflux of toxic proteins such as Aβ from the brain, thereby contributing to neurodegenerative changes in AD. Furthermore, these vascular changes significantly impact drug delivery and distribution within the brain. Therefore, developing targeted delivery systems or therapeutic strategies based on vascular alterations may potentially represent a novel breakthrough in AD treatment. This review comprehensively examines various aspects of vascular alterations in AD and outlines the current interactions between nanoparticles and pathological changes of vascular.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115219"},"PeriodicalIF":16.1,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139943328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration 用于治疗椎间盘变性的微RNA靶向纳米药物

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-22 DOI: 10.1016/j.addr.2024.115214

Hussein H. Genedy , Paul Humbert , Bilel Laoulaou , Brian Le Moal , Marion Fusellier , Catherine Passirani , Catherine Le Visage , Jérôme Guicheux , Élise Lepeltier , Johann Clouet

{"title":"MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration","authors":"Hussein H. Genedy , Paul Humbert , Bilel Laoulaou , Brian Le Moal , Marion Fusellier , Catherine Passirani , Catherine Le Visage , Jérôme Guicheux , Élise Lepeltier , Johann Clouet","doi":"10.1016/j.addr.2024.115214","DOIUrl":"10.1016/j.addr.2024.115214","url":null,"abstract":"<div><p>Low back pain stands as a pervasive global health concern, afflicting almost 80% of adults at some point in their lives with nearly 40% attributable to intervertebral disc degeneration (IVDD). As only symptomatic relief can be offered to patients there is a dire need for innovative treatments.Given the accumulating evidence that multiple microRNAs (miRs) are dysregulated during IVDD, they could have a huge potential against this debilitating condition. The way miRs can profoundly modulate signaling pathways and influence several cellular processes at once is particularly exciting to tackle this multifaceted disorder. However, miR delivery encounters extracellular and intracellular biological barriers. A promising technology to address this challenge is the vectorization of miRs within nanoparticles, providing both protection and enhancing their uptake within the scarce target cells of the degenerated IVD. This comprehensive review presents the diverse spectrum of miRs’ connection with IVDD and demonstrates their therapeutic potential when vectorized in nanomedicines.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115214"},"PeriodicalIF":16.1,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139937777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interaction between particles and vascular endothelium in blood flow 微粒与血管内皮在血流中的相互作用

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-21 DOI: 10.1016/j.addr.2024.115216

Xiaotong Li , Jiahui Zou , Zhongshan He , Yanhua Sun , Xiangrong Song , Wei He

{"title":"The interaction between particles and vascular endothelium in blood flow","authors":"Xiaotong Li , Jiahui Zou , Zhongshan He , Yanhua Sun , Xiangrong Song , Wei He","doi":"10.1016/j.addr.2024.115216","DOIUrl":"10.1016/j.addr.2024.115216","url":null,"abstract":"<div><p>Particle-based drug delivery systems have shown promising application potential to treat human diseases; however, an incomplete understanding of their interactions with vascular endothelium in blood flow prevents their inclusion into mainstream clinical applications. The flow performance of nano/micro-sized particles in the blood are disturbed by many external/internal factors, including blood constituents, particle properties, and endothelium bioactivities, affecting the fate of particles <em>in vivo</em> and therapeutic effects for diseases. This review highlights how the blood constituents, hemodynamic environment and particle properties influence the interactions and particle activities <em>in vivo</em>. Moreover, we briefly summarized the structure and functions of endothelium and simulated devices for studying particle performance under blood flow conditions. Finally, based on particle-endothelium interactions, we propose future opportunities for novel therapeutic strategies and provide solutions to challenges in particle delivery systems for accelerating their clinical translation. This review helps provoke an increasing in-depth understanding of particle-endothelium interactions and inspires more strategies that may benefit the development of particle medicine.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115216"},"PeriodicalIF":16.1,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139917276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoscale contrast agents: A promising tool for ultrasound imaging and therapy 纳米级造影剂：超声成像和治疗的理想工具

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-15 DOI: 10.1016/j.addr.2024.115200

Jieqiong Wang , Yuanyuan Wang , Lin Zhong , Fei Yan , Hairong Zheng

引用次数: 0

Encapsulation and immune protection for type 1 diabetes cell therapy 为 1 型糖尿病细胞疗法提供封装和免疫保护。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-13 DOI: 10.1016/j.addr.2024.115205

Sophia Kioulaphides , Andrés J. García

引用次数: 0