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Advances, challenges, and future directions in the clinical translation of ECM biomaterials for regenerative medicine applications 再生医学应用中 ECM 生物材料临床转化的进展、挑战和未来方向。
IF 16.1 1区 医学
Advanced drug delivery reviews Pub Date : 2024-06-04 DOI: 10.1016/j.addr.2024.115347
Héctor Capella-Monsonís , Raphael J. Crum , George S. Hussey , Stephen F. Badylak
{"title":"Advances, challenges, and future directions in the clinical translation of ECM biomaterials for regenerative medicine applications","authors":"Héctor Capella-Monsonís ,&nbsp;Raphael J. Crum ,&nbsp;George S. Hussey ,&nbsp;Stephen F. Badylak","doi":"10.1016/j.addr.2024.115347","DOIUrl":"10.1016/j.addr.2024.115347","url":null,"abstract":"<div><p>Extracellular Matrix (ECM) scaffolds and biomaterials have been widely used for decades across a variety of diverse clinical applications and have been implanted in millions of patients worldwide. ECM-based biomaterials have been especially successful in soft tissue repair applications but their utility in other clinical applications such as for regeneration of bone or neural tissue is less well understood. The beneficial healing outcome with the use of ECM biomaterials is the result of their biocompatibility, their biophysical properties and their ability to modify cell behavior after injury. As a consequence of successful clinical outcomes, there has been motivation for the development of next-generation formulations of ECM materials ranging from hydrogels, bioinks, powders, to whole organ or tissue scaffolds. The continued development of novel ECM formulations as well as active research interest in these materials ensures a wealth of possibilities for future clinical translation and innovation in regenerative medicine. The clinical translation of next generation formulations ECM scaffolds faces predictable challenges such as manufacturing, manageable regulatory pathways, surgical implantation, and the cost required to address these challenges. The current status of ECM-based biomaterials, including clinical translation, novel formulations and therapies currently under development, and the challenges that limit clinical translation of ECM biomaterials are reviewed herein.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"211 ","pages":"Article 115347"},"PeriodicalIF":16.1,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141282669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria 针对肿瘤中的细菌代谢物进行癌症治疗：针对肿瘤相关细菌的另一种方法
IF 16.1 1区 医学
Advanced drug delivery reviews Pub Date : 2024-06-02 DOI: 10.1016/j.addr.2024.115345
Guofeng Ji , Jingjing Zhao , Xinghui Si , Wantong Song
{"title":"Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria","authors":"Guofeng Ji ,&nbsp;Jingjing Zhao ,&nbsp;Xinghui Si ,&nbsp;Wantong Song","doi":"10.1016/j.addr.2024.115345","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115345","url":null,"abstract":"<div><p>Emerging evidence reveal that tumor-associated bacteria (TAB) can facilitate the initiation and progression of multiple types of cancer. Recent work has emphasized the significant role of intestinal microbiota, particularly bacteria, plays in affecting responses to chemo- and immuno-therapies. Hence, it seems feasible to improve cancer treatment outcomes by targeting intestinal bacteria. While considering variable richness of the intestinal microbiota and diverse components among individuals, direct manipulating the gut microbiota is complicated in clinic. Tumor initiation and progression requires the gut microbiota-derived metabolites to contact and reprogram neoplastic cells. Hence, directly targeting tumor-associated bacteria metabolites may have the potential to provide alternative and innovative strategies to bypass the gut microbiota for cancer therapy. As such, there are great opportunities to explore holistic approaches that incorporates TAB-derived metabolites and related metabolic signals modulation for cancer therapy. In this review, we will focus on key opportunistic areas by targeting TAB-derived metabolites and related metabolic signals, but not bacteria itself, for cancer treatment, and elucidate future challenges that need to be addressed in this emerging field.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"211 ","pages":"Article 115345"},"PeriodicalIF":16.1,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiscale engineering of brain organoids for disease modeling 用于疾病建模的多尺度脑器官工程。
IF 16.1 1区 医学
Advanced drug delivery reviews Pub Date : 2024-05-27 DOI: 10.1016/j.addr.2024.115344
Cong Xu , Alia Alameri , Wei Leong , Emily Johnson , Zaozao Chen , Bin Xu , Kam W. Leong
{"title":"Multiscale engineering of brain organoids for disease modeling","authors":"Cong Xu ,&nbsp;Alia Alameri ,&nbsp;Wei Leong ,&nbsp;Emily Johnson ,&nbsp;Zaozao Chen ,&nbsp;Bin Xu ,&nbsp;Kam W. Leong","doi":"10.1016/j.addr.2024.115344","DOIUrl":"10.1016/j.addr.2024.115344","url":null,"abstract":"<div><p>Brain organoids hold great potential for modeling human brain development and pathogenesis. They recapitulate certain aspects of the transcriptional trajectory, cellular diversity, tissue architecture and functions of the developing brain. In this review, we explore the engineering strategies to control the molecular-, cellular- and tissue-level inputs to achieve high-fidelity brain organoids. We review the application of brain organoids in neural disorder modeling and emerging bioengineering methods to improve data collection and feature extraction at multiscale. The integration of multiscale engineering strategies and analytical methods has significant potential to advance insight into neurological disorders and accelerate drug development.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"210 ","pages":"Article 115344"},"PeriodicalIF":16.1,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive comparison of DNA and RNA vaccines DNA 和 RNA 疫苗的综合比较。
IF 16.1 1区 医学
Advanced drug delivery reviews Pub Date : 2024-05-27 DOI: 10.1016/j.addr.2024.115340
Chunxi Wang, Fan Yuan
{"title":"A comprehensive comparison of DNA and RNA vaccines","authors":"Chunxi Wang,&nbsp;Fan Yuan","doi":"10.1016/j.addr.2024.115340","DOIUrl":"10.1016/j.addr.2024.115340","url":null,"abstract":"<div><p>Nucleic acid technology has revolutionized vaccine development, enabling rapid design and production of RNA and DNA vaccines for prevention and treatment of diseases. The successful deployment of mRNA and plasmid DNA vaccines against COVID-19 has further validated the technology. At present, mRNA platform is prevailing due to its higher efficacy, while DNA platform is undergoing rapid evolution because it possesses unique advantages that can potentially overcome the problems associated with the mRNA platform. To help understand the recent performances of the two vaccine platforms and recognize their clinical potentials in the future, this review compares the advantages and drawbacks of mRNA and DNA vaccines that are currently known in the literature, in terms of development timeline, financial cost, ease of distribution, efficacy, safety, and regulatory approval of products. Additionally, the review discusses the ongoing clinical trials, strategies for improvement, and alternative designs of RNA and DNA platforms for vaccination.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"210 ","pages":"Article 115340"},"PeriodicalIF":16.1,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulating the immune system towards a functional chronic wound healing: A biomaterials and Nanomedicine perspective 调节免疫系统，实现功能性慢性伤口愈合：生物材料与纳米医学的视角
IF 16.1 1区 医学
Advanced drug delivery reviews Pub Date : 2024-05-24 DOI: 10.1016/j.addr.2024.115342
Kevin Las Heras , Itxaso Garcia-Orue , Fiorenza Rancan , Manoli Igartua , Edorta Santos-Vizcaino , Rosa Maria Hernandez
{"title":"Modulating the immune system towards a functional chronic wound healing: A biomaterials and Nanomedicine perspective","authors":"Kevin Las Heras ,&nbsp;Itxaso Garcia-Orue ,&nbsp;Fiorenza Rancan ,&nbsp;Manoli Igartua ,&nbsp;Edorta Santos-Vizcaino ,&nbsp;Rosa Maria Hernandez","doi":"10.1016/j.addr.2024.115342","DOIUrl":"10.1016/j.addr.2024.115342","url":null,"abstract":"<div><p>Chronic non-healing wounds persist as a substantial burden for healthcare systems, influenced by factors such as aging, diabetes, and obesity. In contrast to the traditionally pro-regenerative emphasis of therapies, the recognition of the immune system integral role in wound healing has significantly grown, instigating an approach shift towards immunological processes. Thus, this review explores the wound healing process, highlighting the engagement of the immune system, and delving into the behaviors of innate and adaptive immune cells in chronic wound scenarios. Moreover, the article investigates biomaterial-based strategies for the modulation of the immune system, elucidating how the adjustment of their physicochemical properties or their synergistic combination with other agents such as drugs, proteins or mesenchymal stromal cells can effectively modulate the behaviors of different immune cells. Finally this review explores various strategies based on synthetic and biological nanostructures, including extracellular vesicles, to finely tune the immune system as natural immunomodulators or therapeutic nanocarriers with promising biophysical properties.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"210 ","pages":"Article 115342"},"PeriodicalIF":16.1,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0169409X24001649/pdfft?md5=89e39d8cadbc6da6d3b51f030b927790&pid=1-s2.0-S0169409X24001649-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141131401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art 整合微针和传感策略，用于诊断和监测应用：最新技术
IF 16.1 1区 医学
Advanced drug delivery reviews Pub Date : 2024-05-24 DOI: 10.1016/j.addr.2024.115341
Shihao Pei , Samuel Babity , Ana Sara Cordeiro , Davide Brambilla
{"title":"Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art","authors":"Shihao Pei ,&nbsp;Samuel Babity ,&nbsp;Ana Sara Cordeiro ,&nbsp;Davide Brambilla","doi":"10.1016/j.addr.2024.115341","DOIUrl":"10.1016/j.addr.2024.115341","url":null,"abstract":"<div><p>Microneedles (MNs) offer minimally-invasive access to interstitial fluid (ISF) — a potent alternative to blood in terms of monitoring physiological analytes. This property is particularly advantageous for the painless detection and monitoring of drugs and biomolecules. However, the complexity of the skin environment, coupled with the inherent nature of the analytes being detected and the inherent physical properties of MNs, pose challenges when conducting physiological monitoring using this fluid. In this review, we discuss different sensing mechanisms and highlight advancements in monitoring different targets, with a particular focus on drug monitoring. We further list the current challenges facing the field and conclude by discussing aspects of MN design which serve to enhance their performance when monitoring different classes of analytes.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"210 ","pages":"Article 115341"},"PeriodicalIF":16.1,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141130891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogenic fungi: Novel targets and theranostic strategies 致病真菌：新靶标和治疗策略。
IF 16.1 1区 医学
Advanced drug delivery reviews Pub Date : 2024-05-21 DOI: 10.1016/j.addr.2024.115343
Yue Wang, Linqi Wang, Chong Li
{"title":"Pathogenic fungi: Novel targets and theranostic strategies","authors":"Yue Wang,&nbsp;Linqi Wang,&nbsp;Chong Li","doi":"10.1016/j.addr.2024.115343","DOIUrl":"10.1016/j.addr.2024.115343","url":null,"abstract":"","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"210 ","pages":"Article 115343"},"PeriodicalIF":16.1,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0169409X24001650/pdfft?md5=24053bcbf7922aff9acba37e058b92a1&pid=1-s2.0-S0169409X24001650-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel strategies for modulating the gut microbiome for cancer therapy 调节肠道微生物组以治疗癌症的新策略。
IF 16.1 1区 医学
Advanced drug delivery reviews Pub Date : 2024-05-15 DOI: 10.1016/j.addr.2024.115332
Young Seok Cho , Kai Han , Jin Xu , James J. Moon
{"title":"Novel strategies for modulating the gut microbiome for cancer therapy","authors":"Young Seok Cho ,&nbsp;Kai Han ,&nbsp;Jin Xu ,&nbsp;James J. Moon","doi":"10.1016/j.addr.2024.115332","DOIUrl":"10.1016/j.addr.2024.115332","url":null,"abstract":"<div><p>Recent advancements in genomics, transcriptomics, and metabolomics have significantly advanced our understanding of the human gut microbiome and its impact on the efficacy and toxicity of anti-cancer therapeutics, including chemotherapy, immunotherapy, and radiotherapy. In particular, prebiotics, probiotics, and postbiotics are recognized for their unique properties in modulating the gut microbiota, maintaining the intestinal barrier, and regulating immune cells, thus emerging as new cancer treatment modalities. However, clinical translation of microbiome-based therapy is still in its early stages, facing challenges to overcome physicochemical and biological barriers of the gastrointestinal tract, enhance target-specific delivery, and improve drug bioavailability. This review aims to highlight the impact of prebiotics, probiotics, and postbiotics on the gut microbiome and their efficacy as cancer treatment modalities. Additionally, we summarize recent innovative engineering strategies designed to overcome challenges associated with oral administration of anti-cancer treatments. Moreover, we will explore the potential benefits of engineered gut microbiome-modulating approaches in ameliorating the side effects of immunotherapy and chemotherapy.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"210 ","pages":"Article 115332"},"PeriodicalIF":16.1,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular probes for super-resolution imaging of drug dynamics 用于药物动态超分辨率成像的分子探针。
IF 16.1 1区 医学
Advanced drug delivery reviews Pub Date : 2024-05-10 DOI: 10.1016/j.addr.2024.115330
Hongbao Fang , Mengmeng Wang , Pengfan Wei , Qian Liu , Yan Su , Hongke Liu , Yuncong Chen , Zhi Su , Weijiang He
{"title":"Molecular probes for super-resolution imaging of drug dynamics","authors":"Hongbao Fang ,&nbsp;Mengmeng Wang ,&nbsp;Pengfan Wei ,&nbsp;Qian Liu ,&nbsp;Yan Su ,&nbsp;Hongke Liu ,&nbsp;Yuncong Chen ,&nbsp;Zhi Su ,&nbsp;Weijiang He","doi":"10.1016/j.addr.2024.115330","DOIUrl":"10.1016/j.addr.2024.115330","url":null,"abstract":"<div><p>Super-resolution molecular probes (SRMPs) are essential tools for visualizing drug dynamics within cells, transcending the resolution limits of conventional microscopy. In this review, we provide an overview of the principles and design strategies of SRMPs, emphasizing their role in accurately tracking drug molecules. By illuminating the intricate processes of drug distribution, diffusion, uptake, and metabolism at a subcellular and molecular level, SRMPs offer crucial insights into therapeutic interventions. Additionally, we explore the practical applications of super-resolution imaging in disease treatment, highlighting the significance of SRMPs in advancing our understanding of drug action. Finally, we discuss future perspectives, envisioning potential advancements and innovations in this field. Overall, this review serves to inform and practitioners about the utility of SRMPs in driving innovation and progress in pharmacology, providing valuable insights for drug development and optimization.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"210 ","pages":"Article 115330"},"PeriodicalIF":16.1,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering antigen-presenting cells for immunotherapy of autoimmunity 工程化抗原递呈细胞用于自身免疫的免疫疗法。
IF 16.1 1区 医学
Advanced drug delivery reviews Pub Date : 2024-05-08 DOI: 10.1016/j.addr.2024.115329
Clinton T. Smith , Zhenyu Wang , Jamal S. Lewis
{"title":"Engineering antigen-presenting cells for immunotherapy of autoimmunity","authors":"Clinton T. Smith ,&nbsp;Zhenyu Wang ,&nbsp;Jamal S. Lewis","doi":"10.1016/j.addr.2024.115329","DOIUrl":"10.1016/j.addr.2024.115329","url":null,"abstract":"<div><p>Autoimmune diseases are burdensome conditions that affect a significant fraction of the global population. The hallmark of autoimmune disease is a host’s immune system being licensed to attack its tissues based on specific antigens. There are no cures for autoimmune diseases. The current clinical standard for treating autoimmune diseases is the administration of immunosuppressants, which weaken the immune system and reduce auto-inflammatory responses. However, people living with autoimmune diseases are subject to toxicity, fail to mount a sufficient immune response to protect against pathogens, and are more likely to develop infections. Therefore, there is a concerted effort to develop more effective means of targeting immunomodulatory therapies to antigen-presenting cells, which are involved in modulating the immune responses to specific antigens. In this review, we highlight approaches that are currently in development to target antigen-presenting cells and improve therapeutic outcomes in autoimmune diseases.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"210 ","pages":"Article 115329"},"PeriodicalIF":16.1,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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