Advanced drug delivery reviews最新文献_第10页

Emerging strategies for nanomedicine in autoimmunity 纳米医学在自身免疫方面的新策略。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-10 DOI: 10.1016/j.addr.2024.115194

Ajay S. Thatte , Margaret M. Billingsley , Drew Weissman , Jilian R. Melamed , Michael J. Mitchell

{"title":"Emerging strategies for nanomedicine in autoimmunity","authors":"Ajay S. Thatte , Margaret M. Billingsley , Drew Weissman , Jilian R. Melamed , Michael J. Mitchell","doi":"10.1016/j.addr.2024.115194","DOIUrl":"10.1016/j.addr.2024.115194","url":null,"abstract":"<div><p>Autoimmune disorders have risen to be among the most prevalent chronic diseases across the globe, affecting approximately 5–7% of the population. As autoimmune diseases steadily rise in prevalence, so do the number of potential therapeutic strategies to combat them. In recent years, fundamental research investigating autoimmune pathologies has led to the emergence of several cellular targets that provide new therapeutic opportunities. However, key challenges persist in terms of accessing and specifically combating the dysregulated, self-reactive cells while avoiding systemic immune suppression and other off-target effects. Fortunately, the continued advancement of nanomedicines may provide strategies to address these challenges and bring innovative autoimmunity therapies to the clinic. Through precise engineering and rational design, nanomedicines can possess a variety of physicochemical properties, surface modifications, and cargoes, allowing for specific targeting of therapeutics to pathological cell and organ types. These advances in nanomedicine have been demonstrated in cancer therapies and have the broad potential to advance applications in autoimmunity therapies as well. In this review, we focus on leveraging the power of nanomedicine for prevalent autoimmune disorders throughout the body. We expand on three key areas for the development of autoimmunity therapies – avoiding systemic immunosuppression, balancing interactions with the immune system, and elevating current platforms for delivering complex cargoes – and emphasize how nanomedicine-based strategies can overcome these barriers and enable the development of next-generation, clinically relevant autoimmunity therapies.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115194"},"PeriodicalIF":16.1,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers 超越全身途径的不良影响：利用纳米载体局部治疗皮肤癌。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-09 DOI: 10.1016/j.addr.2024.115197

Beatriz da Silva Gomes , Ana Cláudia Paiva-Santos , Francisco Veiga , Filipa Mascarenhas-Melo

{"title":"Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers","authors":"Beatriz da Silva Gomes , Ana Cláudia Paiva-Santos , Francisco Veiga , Filipa Mascarenhas-Melo","doi":"10.1016/j.addr.2024.115197","DOIUrl":"10.1016/j.addr.2024.115197","url":null,"abstract":"<div><p>Skin cancer is a heterogeneous disease that can be divided into two main groups, melanoma and nonmelanoma skin cancers. Conventional therapies for skin cancer have numerous systemic side effects and a high recurrence rate. Topical treatment is an alternative approach, but drug permeability remains a challenge. Therefore, nanocarriers appear as important nanotechnology tools that reduces both the side effects and improves clinical outcomes. This is why they are attracting growing interest. In this review, scientific articles on the use of nanocarriers for the topical treatment of skin cancer were collected. Despite the promising results of the presented nanocarriers and considering that some of them are already on the market, there is an urgent need for investment in the development of manufacturing methods, as well as of suitable toxicological and regulatory evaluations, since the conventional methods currently used to develop these nanocarriers-based products are more time-consuming and expensive than conventional products.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115197"},"PeriodicalIF":16.1,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0169409X2400019X/pdfft?md5=0c5b62e3daa0674101043ef6939fde0a&pid=1-s2.0-S0169409X2400019X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles are key players in mesenchymal stem cells’ dual potential to regenerate and modulate the immune system 细胞外囊泡是间充质干细胞具有再生和调节免疫系统双重潜力的关键因素。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-09 DOI: 10.1016/j.addr.2024.115203

Martijn van Griensven , Elizabeth R. Balmayor

{"title":"Extracellular vesicles are key players in mesenchymal stem cells’ dual potential to regenerate and modulate the immune system","authors":"Martijn van Griensven , Elizabeth R. Balmayor","doi":"10.1016/j.addr.2024.115203","DOIUrl":"10.1016/j.addr.2024.115203","url":null,"abstract":"<div><p>MSCs are used for treatment of inflammatory conditions or for regenerative purposes. MSCs are complete cells and allogenic transplantation is in principle possible, but mostly autologous use is preferred. In recent years, it was discovered that cells secrete extracellular vesicles. These are active budded off vesicles that carry a cargo. The cargo can be miRNA, protein, lipids etc. The extracellular vesicles can be transported through the body and fuse with target cells. Thereby, they influence the phenotype and modulate the disease. The extracellular vesicles have, like the MSCs, immunomodulatory or regenerative capacities. This review will focus on those features of extracellular vesicles and discuss their dual role. Besides the immunomodulation, the regeneration will concentrate on bone, cartilage, tendon, vessels and nerves. Current clinical trials with extracellular vesicles for immunomodulation and regeneration that started in the last five years are highlighted as well. In summary, extracellular vesicles have a great potential as disease modulating entity and treatment. Their dual characteristics need to be taken into account and often are both important for having the best effect.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115203"},"PeriodicalIF":16.1,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0169409X24000255/pdfft?md5=8a672f38dd65752f4f6c918a1db99291&pid=1-s2.0-S0169409X24000255-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology strategies to address challenges in topical and cellular delivery of siRNAs in skin disease therapy 采用纳米技术策略应对皮肤病治疗中局部和细胞递送 siRNA 的挑战。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-09 DOI: 10.1016/j.addr.2024.115198

Ana Vitoria Pupo Silvestrini, Milena Finazzi Morais, Bryan Wender Debiasi, Fabíola Garcia Praça, Maria Vitória Lopes Badra Bentley

{"title":"Nanotechnology strategies to address challenges in topical and cellular delivery of siRNAs in skin disease therapy","authors":"Ana Vitoria Pupo Silvestrini, Milena Finazzi Morais, Bryan Wender Debiasi, Fabíola Garcia Praça, Maria Vitória Lopes Badra Bentley","doi":"10.1016/j.addr.2024.115198","DOIUrl":"10.1016/j.addr.2024.115198","url":null,"abstract":"<div><p>Gene therapy is one of the most advanced therapies in current medicine. In particular, interference RNA-based therapy by small interfering RNA (siRNA) has gained attention in recent years as it is a highly versatile, selective and specific therapy. In dermatological conditions, topical delivery of siRNA offers numerous therapeutic advantages, mainly by inhibiting the expression of target transcripts directly in the skin. However, crossing the stratum corneum and overcoming intracellular barriers is an inherent challenge. Substantial efforts by scientists have moved towards the use of multimodal and multifunctional nanoparticles to overcome these barriers and achieve greater bioavailability in their site of action, the cytoplasm. In this review the most innovative strategies based on nanoparticle and physical methods are presented, as well as the design principles and the main factors that contribute to the performance of these systems. This review also highlights the synergistic contributions of medicine, nanotechnology, and molecular biology to advancing translational research into siRNA-based therapeutics for skin diseases.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115198"},"PeriodicalIF":16.1,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139715719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing anti-inflammatory pathways and macrophage nano delivery to treat inflammatory and fibrotic disorders 利用抗炎途径和巨噬细胞纳米输送治疗炎症和纤维化疾病。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-09 DOI: 10.1016/j.addr.2024.115204

Ahmad Zaid, Amiram Ariel

{"title":"Harnessing anti-inflammatory pathways and macrophage nano delivery to treat inflammatory and fibrotic disorders","authors":"Ahmad Zaid, Amiram Ariel","doi":"10.1016/j.addr.2024.115204","DOIUrl":"10.1016/j.addr.2024.115204","url":null,"abstract":"<div><p>Targeting specific organs and cell types using nanotechnology and sophisticated delivery methods has been at the forefront of applicative biomedical sciences lately. Macrophages are an appealing target for immunomodulation by nanodelivery as they are heavily involved in various aspects of many diseases and are highly plastic in their nature. Their continuum of functional “polarization” states has been a research focus for many years yielding a profound understanding of various aspects of these cells. The ability of monocyte-derived macrophages to metamorphose from pro-inflammatory to reparative and consequently to pro-resolving effectors has raised significant interest in its therapeutic potential. Here, we briefly survey macrophages' ontogeny and various polarization phenotypes, highlighting their function in the inflammation-resolution shift. We review their inducing mediators, signaling pathways, and biological programs with emphasis on the nucleic acid sensing-IFN-I axis. We also portray the polarization spectrum of macrophages and the characteristics of their transition between different subtypes. Finally, we highlighted different current drug delivery methods for targeting macrophages with emphasis on nanotargeting that might lead to breakthroughs in the treatment of wound healing, bone regeneration, autoimmune, and fibrotic diseases.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115204"},"PeriodicalIF":16.1,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revealing the clinical potential of high-resolution organoids 揭示高分辨率有机体的临床潜力

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-08 DOI: 10.1016/j.addr.2024.115202

Jihoon Ko , Sujin Hyung , Sunghun Cheong , Yoojin Chung , Noo Li Jeon

引用次数: 0

Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway 鼻内给药：纳米颗粒与鼻脑通路之间的相互作用。

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-07 DOI: 10.1016/j.addr.2024.115196

Yaoxing Chen , Chenyun Zhang , Yukun Huang , Yuxiao Ma , Qingxiang Song , Hongzhuan Chen , Gan Jiang , Xiaoling Gao

引用次数: 0

AcousticRobots: Smart acoustically powered micro-/nanoswimmers for precise biomedical applications 声学机器人：用于精确生物医学应用的智能声动力微型/纳米游泳器

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-06 DOI: 10.1016/j.addr.2024.115201

Gege Wu , Wei Xian , Qing You , Jingjing Zhang , Xiaoyuan Chen

{"title":"AcousticRobots: Smart acoustically powered micro-/nanoswimmers for precise biomedical applications","authors":"Gege Wu , Wei Xian , Qing You , Jingjing Zhang , Xiaoyuan Chen","doi":"10.1016/j.addr.2024.115201","DOIUrl":"10.1016/j.addr.2024.115201","url":null,"abstract":"<div><p>Although nanotechnology has evolutionarily progressed in biomedical field over the past decades, achieving satisfactory therapeutic effects remains difficult with limited delivery efficiency. Ultrasound could provide a deep penetration and maneuverable actuation to efficiently power micro-/nanoswimmers with little harm, offering an emerging and fascinating alternative to the active delivery platform. Recent advances in novel fabrication, controllable concepts like intelligent swarm and the integration of hybrid propulsions have promoted its function and potential for medical applications. In this review, we will summarize the mechanisms and types of ultrasonically propelled micro/nanorobots (termed here as “AcousticRobots”), including the interactions between AcousticRobots and acoustic field, practical design considerations (<em>e.g.</em>, component, size, shape), the synthetic methods, surface modification, controllable behaviors, and the advantages when combined with other propulsion approaches. The representative biomedical applications of functional AcousticRobots are also highlighted, including drug delivery, invasive surgery, eradication on the surrounding bio-environment, cell manipulation, detection, and imaging, <em>etc.</em> We conclude by discussing the challenges and outlook of AcousticRobots in biomedical applications.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115201"},"PeriodicalIF":16.1,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139696304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From concept to early clinical trials: 30 years of microbubble-based ultrasound-mediated drug delivery research 从概念到早期临床试验：基于微泡的超声介导给药研究 30 年

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-05 DOI: 10.1016/j.addr.2024.115199

Ayache Bouakaz, Jean Michel Escoffre

{"title":"From concept to early clinical trials: 30 years of microbubble-based ultrasound-mediated drug delivery research","authors":"Ayache Bouakaz, Jean Michel Escoffre","doi":"10.1016/j.addr.2024.115199","DOIUrl":"10.1016/j.addr.2024.115199","url":null,"abstract":"<div><p>Ultrasound mediated drug delivery, a promising therapeutic modality, has evolved remarkably over the past three decades. Initially designed to enhance contrast in ultrasound imaging, microbubbles have emerged as a main vector for drug delivery, offering targeted therapy with minimized side effects. This review addresses the historical progression of this technology, emphasizing the pivotal role microbubbles play in augmenting drug extravasation and targeted delivery. We explore the complex mechanisms behind this technology, from stable and inertial cavitation to diverse acoustic phenomena, and their applications in medical fields. While the potential of ultrasound mediated drug delivery is undeniable, there are still challenges to overcome. Balancing therapeutic efficacy and safety and establishing standardized procedures are essential areas requiring attention. A multidisciplinary approach, gathering collaborations between researchers, engineers, and clinicians, is important for exploiting the full potential of this technology. In summary, this review highlights the potential of using ultrasound mediated drug delivery in improving patient care across various medical conditions.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"206 ","pages":"Article 115199"},"PeriodicalIF":16.1,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0169409X24000218/pdfft?md5=564b495ee664f36c43b7f0ca16133c76&pid=1-s2.0-S0169409X24000218-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139690495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the Mitochondria for Nanomedicine-based Treatments: Overcoming Biological Barriers, Improving Designs, and Selecting Verification Techniques 释放线粒体，实现基于纳米药物的治疗：克服生物学障碍、改进设计和选择验证技术

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-02-05 DOI: 10.1016/j.addr.2024.115195

Camilla Pegoraro, Inés Domingo-Ortí, Inmaculada Conejos-Sánchez, María J. Vicent

{"title":"Unlocking the Mitochondria for Nanomedicine-based Treatments: Overcoming Biological Barriers, Improving Designs, and Selecting Verification Techniques","authors":"Camilla Pegoraro, Inés Domingo-Ortí, Inmaculada Conejos-Sánchez, María J. Vicent","doi":"10.1016/j.addr.2024.115195","DOIUrl":"10.1016/j.addr.2024.115195","url":null,"abstract":"<div><p>Enhanced targeting approaches will support the treatment of diseases associated with dysfunctional mitochondria, which play critical roles in energy generation and cell survival. Obstacles to mitochondria-specific targeting include the presence of distinct biological barriers and the need to pass through (or avoid) various cell internalization mechanisms. A range of studies have reported the design of mitochondrially-targeted nanomedicines that navigate the complex routes required to influence mitochondrial function; nonetheless, a significant journey lies ahead before mitochondrially-targeted nanomedicines become suitable for clinical use. Moving swiftly forward will require safety studies, <em>in vivo</em> assays confirming effectiveness, and methodologies to validate mitochondria-targeted nanomedicines' subcellular location/activity. From a nanomedicine standpoint, we describe the biological routes involved (from administration to arrival within the mitochondria), the features influencing rational design, and the techniques used to identify/validate successful targeting. Overall, rationally-designed mitochondria-targeted-based nanomedicines hold great promise for precise subcellular therapeutic delivery.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"207 ","pages":"Article 115195"},"PeriodicalIF":16.1,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0169409X24000176/pdfft?md5=96c1477b2a2644931d406c3ebd2a2c07&pid=1-s2.0-S0169409X24000176-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139690559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0