Advanced drug delivery reviews最新文献

The molecular circadian clock: From fundamental mechanisms to therapeutic promise in neurological disorders 分子生物钟：从基本机制到神经疾病的治疗前景

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-12 DOI: 10.1016/j.addr.2025.115653

Adam Campbell-Galland, Akanksha Bafna, Aarti Jagannath

{"title":"The molecular circadian clock: From fundamental mechanisms to therapeutic promise in neurological disorders","authors":"Adam Campbell-Galland, Akanksha Bafna, Aarti Jagannath","doi":"10.1016/j.addr.2025.115653","DOIUrl":"https://doi.org/10.1016/j.addr.2025.115653","url":null,"abstract":"Circadian rhythms are intrinsic biological processes in all forms of life, governed by a molecular clock, organising physiological and behavioural cycles to align with a 24-hour light–dark cycle. The disruption of these rhythms has been linked to a plethora of neurological conditions and impacting cognitive and metabolic functions.This review offers a clear overview of the genetic and molecular mechanisms that govern the circadian clock. It focuses on the core clock feedback loops, the pathways involved and how these mechanisms are regulated. We explore how clocks in peripheral tissues are synchronised to the suprachiasmatic nucleus and how this is achieved through neuronal and humoral pathways. Additionally, we discuss how dysregulation in circadian rhythms contribute to neurological conditions and potential therapeutic treatments targeting circadian mechanisms. Understanding the mechanisms of circadian dysregulation provides insight into disease pathology and potential therapies. Interventions targeting circadian mechanisms, such as gene and drug delivery systems, show promise to restore rhythms and mitigate neurological symptoms. This review collates current knowledge on circadian biology and its applications addressing neurological dysfunctions, providing a foundation for potential chronotherapeutic interventions.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"28 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibody-drug conjugates as multimodal therapies against hard-to-treat cancers 抗体-药物结合作为多模式治疗难以治疗的癌症

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-11 DOI: 10.1016/j.addr.2025.115648

Georgina B Armstrong, Harriet Graham, Anthony Cheung, Hanieh Montaseri, Glenn A Burley, Sophia N Karagiannis, Zahra Rattray

{"title":"Antibody-drug conjugates as multimodal therapies against hard-to-treat cancers","authors":"Georgina B Armstrong, Harriet Graham, Anthony Cheung, Hanieh Montaseri, Glenn A Burley, Sophia N Karagiannis, Zahra Rattray","doi":"10.1016/j.addr.2025.115648","DOIUrl":"https://doi.org/10.1016/j.addr.2025.115648","url":null,"abstract":"Antibody-drug conjugates (ADCs) are rapidly emerging as an effective multimodal approach for the targeted delivery of cytotoxic small molecule to tumours with aberrantly overexpressed markers. Recent advances in antibody engineering and the emergence of highly potent cytotoxic drugs have created unprecedented scope for precision-based design of novel ADCs against chemotherapy-resistant tumours. However, their clinical translation faces the challenge of balancing efficacy and toxicity. Innovations in conjugation chemistries and antibody engineering are addressing these challenges, yet a more comprehensive <em>in vitro − in vivo</em> correlation is critical to accelerating their clinical translation. This review examines the latest advancements in ADC-based therapies for hard-to-treat cancers, focusing on design considerations that define their efficacy in breast cancer and glioblastoma multiforme. Additionally, we highlight current challenges in reconciling ADC quality attributes influencing their <em>in vivo</em> performance, which impedes their clinical translation. By integrating cutting-edge advancements in antibody engineering with industrial insights, this review casts a spotlight on the pivotal role of ADCs as a powerful biomolecular toolbox for delivering next-generation therapies to address unmet clinical need.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"14 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lights out for Superbugs: Is antimicrobial blue light a potential approach for future infection Control? 超级细菌熄灯：抗菌蓝光是未来感染控制的潜在方法吗？

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-10 DOI: 10.1016/j.addr.2025.115654

Gizem D. Ozdemir, Carolina dos Anjos, Mehmet A. Ozdemir, Leon G. Leanse, Tianhong Dai

{"title":"Lights out for Superbugs: Is antimicrobial blue light a potential approach for future infection Control?","authors":"Gizem D. Ozdemir, Carolina dos Anjos, Mehmet A. Ozdemir, Leon G. Leanse, Tianhong Dai","doi":"10.1016/j.addr.2025.115654","DOIUrl":"https://doi.org/10.1016/j.addr.2025.115654","url":null,"abstract":"The rise of antimicrobial resistance (AMR) poses a significant threat to global health, as traditional antimicrobials are increasingly losing efficacy against a broad spectrum of pathogens. Antimicrobial blue light (aBL), an innovative light-based approach that utilizes wavelengths between 405 and 470 nm, has emerged as a prominent alternative. Unlike conventional antimicrobials, aBL inactivates microorganisms without promoting resistance by targeting endogenous chromophores within pathogens to generate reactive oxygen species (ROS). This review first provides an in-depth analysis of aBL’s mechanisms of action, highlighting its unique ROS-driven effects on microbial membranes, DNA, and proteins. Moreover, we discussed recent developments in aBL’s applications across bacterial, viral, and fungal pathogens and evaluated its effectiveness in biofilm eradication and combinational therapies with conventional antimicrobials as well as with multimodal innovations. This review also examines the safety and regulatory considerations associated with aBL. While aBL holds tremendous potential, challenges remain in its clinical translation, including optimizing dosages, ensuring safety in complex biological systems, and advancing device design. Future research must address these gaps to facilitate the clinical translation of aBL and expand its role in combating resistant infections.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"108 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing carbon nanomaterials for reactive oxygen species regulation: Insights into generation, scavenging, and sensing 利用碳纳米材料的活性氧调节：洞察产生，清除，和传感

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-10 DOI: 10.1016/j.addr.2025.115651

Zhanpeng Jim Liu, Arpita Roy, Yuting Zheng, Nasim Annabi

{"title":"Harnessing carbon nanomaterials for reactive oxygen species regulation: Insights into generation, scavenging, and sensing","authors":"Zhanpeng Jim Liu, Arpita Roy, Yuting Zheng, Nasim Annabi","doi":"10.1016/j.addr.2025.115651","DOIUrl":"https://doi.org/10.1016/j.addr.2025.115651","url":null,"abstract":"Carbon nanomaterials (CBNs) have driven significant research advances in medicine over the past decades due to their unique structures and properties. In particular, the role of CBNs in regulating reactive oxygen species (ROS) has been extensively studied recently. ROS, primarily comprising free radicals and non-radical species of oxygen, are recognized as critical byproducts of cell metabolism. ROS level is vital for local cell and tissue homeostasis, facilitating cell–cell communication, and stabilizing the redox system under normal conditions. However, excessive accumulation of ROS can cause oxidative stress, leading to aging and serious pathologies. As a result, the regulation of ROS in various diseases has garnered significant attention. In this regard, understanding the interaction of CBNs with ROS is critical for their biomedical applications. This review article highlights the dual role of ROS in the tissue microenvironment and emphasizes the significance of the structure–property relationship of CBNs in regulating ROS. It further identifies emerging trends in recent studies on CBN-based ROS regulation including generation, scavenging, and sensing. Specifically, the potential for dynamic modulation of the tissue microenvironment through the combined generation and scavenging of ROS is highlighted. Finally, future perspectives are discussed, with a focus on discussing the biosafety and potential clinical applications of CBNs, along with recent advances in sensing technologies and a deeper understanding of redox biology. Together, these insights aim to provide a foundation for designing CBN-based biomaterials for both ROS therapeutic and monitoring applications.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"11 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the complexities of pancreatic ductal adenocarcinoma: A review on therapeutic models and RAS inhibitors 胰腺导管腺癌的复杂性：治疗模型和RAS抑制剂的综述

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-09 DOI: 10.1016/j.addr.2025.115652

Sara Barrambana, Elena Zamorano-Domínguez, Vasiliki Liaki, Carmen Guerra

引用次数: 0

Gut-brain-immune interactions: exploring probiotics as a drug delivery platform for neurological disease 肠道-脑免疫相互作用：探索益生菌作为神经系统疾病的药物传递平台

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-09 DOI: 10.1016/j.addr.2025.115650

Chinmayi R. Gudi, Michael J. Wannemuehler, Thomas J. Mansell

{"title":"Gut-brain-immune interactions: exploring probiotics as a drug delivery platform for neurological disease","authors":"Chinmayi R. Gudi, Michael J. Wannemuehler, Thomas J. Mansell","doi":"10.1016/j.addr.2025.115650","DOIUrl":"https://doi.org/10.1016/j.addr.2025.115650","url":null,"abstract":"The gut-brain-immune (GBI) axis, connecting gut microbes, neural tissue, and the cells of the immune system, plays a critical role in human health, particularly in relation to neurological diseases. Research in this field over the last few decades shows that disruptions in the microbiome have been linked to chronic inflammation, which may contribute to neurological conditions, including Parkinson’s disease, Alzheimer’s disease, and other mental health disorders. As we gain a greater understanding of the links between these systems, novel therapeutic strategies are being explored to treat disease by modulation of the GBI axis. One of the most promising approaches is the use of live biotherapeutics, such as engineered probiotics, as next-generation drug delivery systems. These live microorganisms can be designed to deliver specific therapeutic compounds to the gut and brain in order to modulate immune responses and reduce inflammation at the source. Probiotics and live biotherapeutics can offer a targeted approach to treating neurological diseases by influencing both the microbiome and immune system. In this review, we outline the research and mechanisms that have been implicated in GBI interactions and highlight the potential of these innovative therapies in treating neurological disorders, emphasizing their role in improving precision medicine through targeted, microbiome-based interventions.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"692 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gelatin-integrated carbon nanomaterials in nanomedicine: From biosensing and bioprinting to tissue engineering and other biomedical applications 纳米医学中的明胶集成碳纳米材料：从生物传感和生物打印到组织工程和其他生物医学应用

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-09 DOI: 10.1016/j.addr.2025.115649

Mahdi Saeidirad, Nooshin Naderi, Saminalsadat Sehat, Fateme Sadat Qazi, Iman Zare, Mahsa Imani, Heemin Kang, Mojdeh Mirshafiei, Morvarid Koohkhezri, Zahra Sadat, Amir Kashtiaray, Mohammad Mahdavi, Reza Eivazzadeh-Keihan, Ali Maleki, Jianliang Shen

{"title":"Gelatin-integrated carbon nanomaterials in nanomedicine: From biosensing and bioprinting to tissue engineering and other biomedical applications","authors":"Mahdi Saeidirad, Nooshin Naderi, Saminalsadat Sehat, Fateme Sadat Qazi, Iman Zare, Mahsa Imani, Heemin Kang, Mojdeh Mirshafiei, Morvarid Koohkhezri, Zahra Sadat, Amir Kashtiaray, Mohammad Mahdavi, Reza Eivazzadeh-Keihan, Ali Maleki, Jianliang Shen","doi":"10.1016/j.addr.2025.115649","DOIUrl":"https://doi.org/10.1016/j.addr.2025.115649","url":null,"abstract":"Carbon nanomaterials (CNMs) in combination with hydrogels (gelatin (Gel)) have shown significant potential in diagnostic and therapeutic applications. This study highlights their significant potential and explores their transformative role in biomedicine. By integrating Gel with CNMs, unique synergistic properties combine mechanical, biocompatibility, and biodegradability properties with the exceptional characteristics of nanomaterials, including high surface area, mechanical strength, and functionalization capabilities. These advanced nanocomposites exhibit remarkable potential across diverse biomedical applications such as cancer therapy, bioprinting applications, tissue engineering and regenerative medicine, wound healing, antimicrobial activity, and bio-packaging. Overall, Gel-integrated CNMs represent a new class of materials with significant promise in advancing biosensing technologies and biomedical performance. Their unique combination of properties opens up new opportunities for the development of next-generation healthcare technologies, improved diagnostics, therapies, and medical devices with enhanced performance and functionality.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"195 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies 克服胰腺癌治疗耐药：挑战和新兴策略

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-09 DOI: 10.1016/j.addr.2025.115647

Taymin du Toit-Thompson, Lionel Leck, Josef Gillson, Nick Pavlakis, Anthony J. Gill, Jaswinder S. Samra, Anubhav Mittal, Sumit Sahni

引用次数: 0

From cell-SELEX to tissue-SELEX for targeted drug delivery and aptamer nanomedicine 从细胞selex到组织- selex用于靶向药物递送和适体纳米药物

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-04 DOI: 10.1016/j.addr.2025.115646

Ka-Ying Wong , Man-Sau Wong , Jung Heon Lee , Juewen Liu

{"title":"From cell-SELEX to tissue-SELEX for targeted drug delivery and aptamer nanomedicine","authors":"Ka-Ying Wong , Man-Sau Wong , Jung Heon Lee , Juewen Liu","doi":"10.1016/j.addr.2025.115646","DOIUrl":"10.1016/j.addr.2025.115646","url":null,"abstract":"<div><div>Aptamers are nucleic acid-based ligands that can selectively bind to target molecules. Because of their unique target-binding properties, the use of aptamers for targeting cell surface molecules has attracted broad research interest. The field has evolved from selecting aptamers against purified surface proteins to using whole cells (cell-SELEX) as targets. To further advance the field, the concept of tissue-SELEX was later proposed to ensure that selected aptamers possess optimal binding properties in more native <em>in vivo</em> environments. In this article, we review recent progress made for tissue-SELEX, covering methods including tissue slide-based SELEX, morph-X-SELEX, <em>ex vivo</em>-SELEX, and microfluidic tissue-SELEX. The target tissues include cornea, breast, ovary, lung, cardiac and thyroid tissues. For the diseases targeted, cancer is the most extensively studied followed by cardiomyopathies and vascular conditions. The advantages of each method are discussed and potential limitations are also critically reviewed. Applications of tissue- or <em>in vivo</em>-SELEX-derived aptamers in drug delivery include local administration for ocular diseases and systemic administration for lung cancer. Finally, future directions are discussed, emphasizing the need for systematic comparative studies to evaluate cell-SELEX and tissue-SELEX derived aptamers, using antibodies as benchmarks to guide the development of clinically relevant therapeutic applications.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"224 ","pages":"Article 115646"},"PeriodicalIF":15.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergen to asset: Pollen-based drug delivery systems 过敏原对资产：基于花粉的药物输送系统

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-03 DOI: 10.1016/j.addr.2025.115643

Mohammed Shahrudin Ibrahim , Abdul Rahim Ferhan , Chenchen Zhou , Jian Li , Yu-Chien Lin , Jingyu Deng , Ze Zhao , Nam-Joon Cho

{"title":"Allergen to asset: Pollen-based drug delivery systems","authors":"Mohammed Shahrudin Ibrahim , Abdul Rahim Ferhan , Chenchen Zhou , Jian Li , Yu-Chien Lin , Jingyu Deng , Ze Zhao , Nam-Joon Cho","doi":"10.1016/j.addr.2025.115643","DOIUrl":"10.1016/j.addr.2025.115643","url":null,"abstract":"<div><div>The rising demand for therapeutics, driven by aging populations and chronic diseases, challenges the pharmaceutical manufacturing of sustainable drug delivery systems. While development of microcarriers from natural sources such as plant or animal-sourced polymers and lipids show promise, the resource-intensive and complex processes involved limits their translatability and access. In this review, we discuss briefly the existing microcarriers fabricated from natural polymers and transition to recent efforts that have been devoted to exemplify pollen, traditionally regarded as an allergen, exhibits qualities that fit the criteria of a desirable microcarrier, and can be exploited to be valuable drug delivery assets with potential of encapsulating a wide spectrum of cargo and targeted conveyance. We scope through the various derivatives of pollen-derived microcarriers, especially highlighting the recent development of the soft pollen microgel variants, which was designed in alignment with the concept of Cross Economy of transforming abundant, low-value materials to create high-value products through easily portable, innovative and effective processing methods. We further discuss the future outlook of the pollen microgel and suggest aspects of pollen research that needs to be pursued to realize its translation to be a sustainable asset to drug delivery applications.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"224 ","pages":"Article 115643"},"PeriodicalIF":15.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0