Advanced drug delivery reviews最新文献

{"title":"Devices to overcome the buccal mucosal barrier to administer Therapeutic Peptides","authors":"Sahil Malhotra, Thomas Lijnse, Eoin O’ Cearbhaill, David J. Brayden","doi":"10.1016/j.addr.2025.115572","DOIUrl":"https://doi.org/10.1016/j.addr.2025.115572","url":null,"abstract":"Peptide therapeutics are important in healthcare owing to their high target specificity, therapeutic efficacy, and relatively low side effect profile. Injections of these agents have improved the<!-- --> <!-- -->treatment of chronic diseases including autoimmune, metabolic disorders, and cancer. However, their administration via injections can prove a barrier to patient acceptability of treatments. While oral delivery of these molecules is preferable, oral peptide formulations are associated with limited bioavailability due to degradation in the intestine and low epithelial permeability. Buccal administration of peptides is a potential alternative to injections and oral formulations. Similar to the oral route, the buccal route can promote better patient adherence to dosing regimens, along with the added advantages of not requiring restriction on food or drink consumption before and after administration, as well as avoidance of the liver first-pass metabolism. However, like oral, effective buccal absorption of peptides is still challenging due to the high epithelial permeability barrier. We present a multidisciplinary approach to understanding the buccal physiological barrier to macromolecule permeation and discuss how engineered devices may overcome it. Selected examples of buccal devices can facilitate fast and efficient macromolecule absorption through multiple mechanisms including physical disruption of epithelia, convection-based mass transfer, and a combination of physicochemical strategies. Importantly, minimally invasive devices can be self-applied and are associated with the maintenance of the barrier after exposure. We analysed the critical attributes that are required for<!-- --> <!-- -->the clinical translation of buccal peptide administration devices. These include performance-driven device development, manufacturing features, patient acceptability, and commercial viability.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"19 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating the electronic structure of graphdiyne-based nanomaterials for engineering nano-bio interfaces in biomedical applications","authors":"Hui Wang ,&nbsp;Xiaoyu Zhang ,&nbsp;Jing Liu ,&nbsp;Chunying Chen","doi":"10.1016/j.addr.2025.115570","DOIUrl":"10.1016/j.addr.2025.115570","url":null,"abstract":"<div><div>Graphdiyne (GDY), a two-dimensional (2D) carbon allotrope featuring a unique electronic structure, has attracted considerable attention due to its outstanding properties and potential applications in various fields, particularly in biomedicine due to its exceptional surface area, tunable electronic structure, and biocompatibility. Although promising, this field is still in the proof-of-concept stage due to incomplete understanding of the effects of structural regulation, particularly electronic structure, of GDY-based nanomaterials on their nano-bio interfaces, which seriously hinders the research of GDY-based nanomaterials in the biomedical field. To provide a comprehensive understanding of the relationship between electronic structures and nano-bio interfaces, this review focuses on the modulation of the electronic structure of GDY-based nanomaterials and its implications for engineering nano-bio interfaces for biomedical applications. Firstly, we delve into the intrinsic electronic properties of GDY, including its bandgap tunability and high carrier mobility, which are critical for its functionality in biomedical applications. We then discuss strategies for modulating these properties through oxidation, nonmetallic doping, covalent modification, and metal loading, aiming to optimize the electronic structure of GDY-based nanomaterials for superior performance in specific biomedical contexts, such as biomedical imaging, surface and interface catalysis, free radical scavenging, and drug delivery. Furthermore, we provide an overview of the methodologies for the investigation of these electronic properties, including theoretical simulation, characterization techniques, and real-time analysis of electron transfer at the nano-bio interfaces, highlighting their roles in advancing our understanding and guiding the design of novel GDY-based materials. Finally, this review provides an outlook on future research directions aimed at further optimizing the design of GDY-based nanomaterials and nano-bio interfaces, emphasizing the need for interdisciplinary collaboration to overcome current challenges and to fully realize the potential of GDY-based nanomaterials in biomedical applications. These principles are anticipated to facilitate the future development and clinical translation of precise, safe, and effective nanomedicines with intelligent theranostic features.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115570"},"PeriodicalIF":15.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography for noninvasive monitoring of drug delivery","authors":"Salavat R. Aglyamov,&nbsp;Kirill V. Larin","doi":"10.1016/j.addr.2025.115571","DOIUrl":"10.1016/j.addr.2025.115571","url":null,"abstract":"<div><div>Optical Coherence Tomography (OCT) has revolutionized various medical imaging and diagnostics fields, offering unprecedented insights into the microstructural compositions of biological tissues. In recent years, OCT applications have been extended to noninvasive drug delivery monitoring, which is a critical aspect of many therapeutic procedures and pharmacokinetic studies. Such an extension is strongly enhanced by the inherent combination with 3D anatomical images provided by OCT. This review presents an overview of the principles of OCT technology, its functional extensions for drug delivery systems, and its advancements in monitoring therapeutic interventions. We discuss its advantages over traditional imaging modalities in terms of spatial resolution, depth penetration, and real-time capabilities. The paper highlights significant studies that have utilized OCT for the visualization and quantification of drug delivery processes, including the diffusion of injectable formulations in ocular tissues and the permeation of topical drugs through the skin. In the review, we focused on the latest OCT applications, including OCT-guided drug injection, topical drug delivery monitoring, application of OCT in inhaled drug delivery systems, and the integration of OCT with other imaging modalities.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115571"},"PeriodicalIF":15.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles targeting the central circadian clock: Potential applications for neurological disorders","authors":"Marion Le Meur ,&nbsp;Jaime Pignatelli ,&nbsp;Paolo Blasi ,&nbsp;Valle Palomo","doi":"10.1016/j.addr.2025.115561","DOIUrl":"10.1016/j.addr.2025.115561","url":null,"abstract":"<div><div>Circadian rhythms and their involvement with various human diseases, including neurological disorders, have become an intense area of research for the development of new pharmacological treatments. The location of the circadian clock machinery in the central nervous system makes it challenging to reach molecular targets at therapeutic concentrations. In addition, a timely administration of the therapeutic agents is necessary to efficiently modulate the circadian clock. Thus, the use of nanoparticles in circadian clock dysfunctions may accelerate their clinical translation by addressing these two key challenges: enhancing brain penetration and/or enabling their formulation in chronodelivery systems. This review describes the implications of the circadian clock in neurological pathologies, reviews potential molecular targets and their modulators and suggests how the use of nanoparticle-based formulations could improve their clinical success. Finally, the potential integration of nanoparticles into chronopharmaceutical drug delivery systems will be described.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115561"},"PeriodicalIF":15.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Tumor-Associated Microbiome: A New Aspect of Modulating Tumor Microenvironment for Cancer Therapy","authors":"Wantong Song, Leaf Huang","doi":"10.1016/j.addr.2025.115554","DOIUrl":"https://doi.org/10.1016/j.addr.2025.115554","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Declaration of competing interest</h2>The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</section></section>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"52 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printing in musculoskeletal interface engineering: Current progress and future directions","authors":"Tianpeng Xu ,&nbsp;Jingdong Rao ,&nbsp;Yongyi Mo ,&nbsp;Avery Chik-Him Lam ,&nbsp;Yuhe Yang ,&nbsp;Sidney Wing-Fai Wong ,&nbsp;Ka-Hing Wong ,&nbsp;Xin Zhao","doi":"10.1016/j.addr.2025.115552","DOIUrl":"10.1016/j.addr.2025.115552","url":null,"abstract":"<div><div>The musculoskeletal system relies on critical tissue interfaces for its function; however, these interfaces are often compromised by injuries and diseases. Restoration of these interfaces is complex by nature which renders traditional treatments inadequate. An emerging solution is three-dimensional printing, which allows for precise fabrication of biomimetic scaffolds to enhance tissue regeneration. This review summarizes the use of 3D printing in creating scaffolds for musculoskeletal interfaces, mainly focusing on advanced techniques such as multi-material printing, bioprinting, and 4D printing. We emphasize the significance of mimicking natural tissue gradients and the selection of appropriate biomaterials to ensure scaffold success. The review outlines state-of-the-art 3D printing technologies, varying from extrusion, inkjet and laser-assisted bioprinting, which are crucial for producing scaffolds with tailored mechanical and biological properties. Applications in cartilage-bone, intervertebral disc, tendon/ligament-bone, and muscle–tendon junction engineering are discussed, highlighting the potential for improved integration and functionality. Furthermore, we address challenges in material development, printing resolution, and the <em>in vivo</em> performance of scaffolds, as well as the prospects for clinical translation. The review concludes by underscoring the transformative potential of 3D printing to advance orthopedic medicine, offering a roadmap for future research at the intersection of biomaterials, drug delivery, and tissue engineering.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"219 ","pages":"Article 115552"},"PeriodicalIF":15.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MIDD in Japan– Implementations, challenges and opportunities","authors":"Mayumi Hasegawa ,&nbsp;Shinichi Kijima","doi":"10.1016/j.addr.2025.115553","DOIUrl":"10.1016/j.addr.2025.115553","url":null,"abstract":"<div><div>In Japan, there has been a growing adoption of Model Informed Drug Development (MIDD) approaches as the rationale for optimal dose decision and modeling outputs have supported better characterizing the risk–benefit profile of a drug by accelerating development period and regulatory-approval pathways. Three primary guidelines on pharmacometric analysis tools issued in Japan between 2019 and 2020 function as a shared communication medium between pharmaceutical companies and the regulatory agency in Japan and have contributed to increasing number of MIDD applications embedded into new drug application documents. This review article describes how the Pharmaceuticals and Medical Devices Agency have been promoting the adoption of modeling and simulation and how MIDD applications have been implemented in Japan by introducing multiple case studies. The intent is to share the knowledge and to promote the harmonization of regulations globally for accelerating the appropriate utilization of MIDD tools and implementation of various new technologies. (149 words)</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115553"},"PeriodicalIF":15.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the EPR effect: Intravital microscopy analysis of nanoparticle drug delivery to tumors","authors":"Iaroslav B. Belyaev ,&nbsp;Olga Yu. Griaznova ,&nbsp;Alexey V. Yaremenko ,&nbsp;Sergey M. Deyev ,&nbsp;Ivan V. Zelepukin","doi":"10.1016/j.addr.2025.115550","DOIUrl":"10.1016/j.addr.2025.115550","url":null,"abstract":"<div><div>Delivery of nanoparticles (NPs) to solid tumors has long relied on enhanced permeability and retention (EPR) effect, involving permeation of NPs through a leaky vasculature with prolonged retention by reduced lymphatic drainage in tumor. Recent research studies and clinical data challenge EPR concept, revealing alternative pathways and approaches of NP delivery. The area was significantly impacted by the implementation of intravital optical microscopy, unraveling delivery mechanisms at cellular level <em>in vivo</em>. This review presents analysis of the reasons for EPR heterogeneity in tumors and describes non-EPR based concepts for drug delivery, which can supplement the current paradigm. One of the approaches is targeting tumor endothelium by NPs with subsequent intravascular drug release and gradient-driven drug transport to tumor interstitium. Others exploit various immune cells for tumor infiltration and breaking endothelial barriers. Finally, we discuss the involvement of active transcytosis through endothelial cells in NP delivery. This review aims to inspire further understanding of the process of NP extravasation in tumors and provide insights for developing next-generation nanomedicines with improved delivery.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"219 ","pages":"Article 115550"},"PeriodicalIF":15.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic tweezers for targeted drug delivery","authors":"Léa Guerassimoff ,&nbsp;Stefaan C. De Smedt ,&nbsp;Félix Sauvage ,&nbsp;Michael Baudoin","doi":"10.1016/j.addr.2025.115551","DOIUrl":"10.1016/j.addr.2025.115551","url":null,"abstract":"<div><div>Acoustic tweezers are a highly promising technology for targeted drug delivery thanks to their unique capabilities: (i) they can effectively operate in both <em>in vitro</em> and <em>in vivo</em> environments, (ii) they can manipulate a wide range of particle sizes and materials, and (iii) they can exert forces several orders of magnitude larger than competing techniques while remaining safe for biological tissues. In particular, tweezers capable of selectively capturing and manipulating objects in 3D with a single beam, known as ‘single beam tweezers’, open new perspectives for delivering drug carriers to precise locations. In this review, we first introduce the fundamental physical principles underlying the manipulation of particles using acoustic tweezers and highlight the latest advancements in the field. We then discuss essential considerations for the design of drug delivery carriers suitable for use with acoustic tweezers. Finally, we summarise recent promising studies that explore the use of acoustic tweezers for <em>in vitro</em>, <em>ex vivo</em>, and <em>in vivo</em> drug delivery.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115551"},"PeriodicalIF":15.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PhotoChem Interplays: Lighting the Way for Drug Delivery and Diagnosis","authors":"Asmita Banstola,&nbsp;Zuan-Tao Lin,&nbsp;Yongli Li,&nbsp;Mei X. Wu","doi":"10.1016/j.addr.2025.115549","DOIUrl":"10.1016/j.addr.2025.115549","url":null,"abstract":"<div><div>Light, a non-invasive tool integrated with cutting-edge nanotechnologies, has driven transformative advancements in imaging-based diagnosis and drug delivery for cancer and bacterial treatments. This review discusses recent progress in these areas, beginning with emerging imaging technologies. Unlike traditional photosensors activated by visible light, alternative energy sources such as near-infrared (NIR) light, X-rays, and ultrasound have been extensively investigated to activate various photosensors, achieving high sensitivity, wavelength versatility, and spatial resolution for deep-tissue imaging. Moreover, to address challenges like tissue autofluorescence in real-time fluorescence imaging, afterglow luminescent nanoparticles are being developed by integrating these alternative energy sources for real-time imaging and sensing in deep tissue for precise cancer diagnosis and treatment beyond superficial tissues. In addition to deep tissue imaging, light-responsive nanomedicines are revolutionizing anticancer and antimicrobial phototherapy by enabling spatially and temporally controlled drug release. These smart nanoparticles are engineered to release therapeutic cargo at target sites in response to microenvironmental cues specific to tumors or infections. In anticancer phototherapy, these nanoparticles facilitate controlled drug release via photoisomerization, photothermal, and photodynamic processes. To enhance circulation time and specific targeting, biomimetic nanoparticles, which mimic natural anti-tumor responses by our body, have attracted increasing attention. In antimicrobial phototherapy, research has been focused on the chemical modification of the photosensitizer to enable targeted drug delivery. An intriguing strategy has recently emerged involving the development of “pro-photosensitizers” that are specifically activated within bacterial cells upon light irradiation, offering a high margin of safety. These advancements leverage photochemical reactions and nanotechnology to enhance precision therapy and diagnosis in addressing critical health challenges.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"219 ","pages":"Article 115549"},"PeriodicalIF":15.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}