Advanced drug delivery reviews最新文献

Beyond the EPR effect: Intravital microscopy analysis of nanoparticle drug delivery to tumors

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-26 DOI: 10.1016/j.addr.2025.115550

Iaroslav B. Belyaev, Olga Yu. Griaznova, Alexey V. Yaremenko, Sergey M. Deyev, Ivan V. Zelepukin

{"title":"Beyond the EPR effect: Intravital microscopy analysis of nanoparticle drug delivery to tumors","authors":"Iaroslav B. Belyaev, Olga Yu. Griaznova, Alexey V. Yaremenko, Sergey M. Deyev, Ivan V. Zelepukin","doi":"10.1016/j.addr.2025.115550","DOIUrl":"https://doi.org/10.1016/j.addr.2025.115550","url":null,"abstract":"Delivery of nanoparticles (NPs) to solid tumors has long relied on enhanced permeability and retention (EPR) effect, involving permeation of NPs through a leaky vasculature with prolonged retention by reduced lymphatic drainage in tumor. Recent research studies and clinical data challenge EPR concept, revealing alternative pathways and approaches of NP delivery. The area was significantly impacted by the implementation of intravital optical microscopy, unraveling delivery mechanisms at cellular level <em>in vivo</em>. This review presents analysis of the reasons for EPR heterogeneity in tumors and describes non-EPR based concepts for drug delivery, which can supplement the current paradigm. One of the approaches is targeting tumor endothelium by NPs with subsequent intravascular drug release and gradient-driven drug transport to tumor interstitium. Others exploit various immune cells for tumor infiltration and breaking endothelial barriers. Finally, we discuss the involvement of active transcytosis through endothelial cells in NP delivery. This review aims to inspire further understanding of the process of NP extravasation in tumors and provide insights for developing next-generation nanomedicines with improved delivery","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"32 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acoustic tweezers for targeted drug delivery

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-21 DOI: 10.1016/j.addr.2025.115551

Léa Guerassimoff, Stefaan C. De Smedt, Félix Sauvage, Michael Baudoin

引用次数: 0

Application of photosensitive microalgae in targeted tumor therapy

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-13 DOI: 10.1016/j.addr.2025.115519

Ruoxi Wang , Zhouyue Wang , Min Zhang , Danni Zhong , Min Zhou

{"title":"Application of photosensitive microalgae in targeted tumor therapy","authors":"Ruoxi Wang , Zhouyue Wang , Min Zhang , Danni Zhong , Min Zhou","doi":"10.1016/j.addr.2025.115519","DOIUrl":"10.1016/j.addr.2025.115519","url":null,"abstract":"<div><div>Microalgae present a novel and multifaceted approach to cancer therapy by modulating the tumor-associated microbiome (TAM) and the tumor microenvironment (TME). Through their ability to restore gut microbiota balance, reduce inflammation, and enhance immune responses, microalgae contribute to improved cancer treatment outcomes. As photosynthetic microorganisms, microalgae exhibit inherent anti-tumor, antioxidant, and immune-regulating properties, making them valuable in photodynamic therapy and tumor imaging due to their capacity to generate reactive oxygen species. Additionally, microalgae serve as effective drug delivery vehicles, leveraging their biocompatibility and unique structural properties to target the TME more precisely. Microalgae-based microrobots further expand their therapeutic potential by autonomously navigating complex biological environments, offering a promising future for precision-targeted cancer treatments. We position microalgae as a multifunctional agent capable of modulating TAM, offering novel strategies to enhance TME and improve the efficacy of cancer therapies.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"219 ","pages":"Article 115519"},"PeriodicalIF":15.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printing of pharmaceutical dosage forms: Recent advances and applications 药物剂型的3D打印：最新进展和应用

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115504

Tobias Auel , Aaron Felix Christofer Mentrup , Lee Roy Oldfield , Anne Seidlitz

{"title":"3D printing of pharmaceutical dosage forms: Recent advances and applications","authors":"Tobias Auel , Aaron Felix Christofer Mentrup , Lee Roy Oldfield , Anne Seidlitz","doi":"10.1016/j.addr.2024.115504","DOIUrl":"10.1016/j.addr.2024.115504","url":null,"abstract":"<div><div>Three-dimensional (3D) printing, also referred to as additive manufacturing, is considered to be a game-changing technology in many industries and is also considered to have potential use cases in pharmaceutical manufacturing, especially if individualization is desired. In this review article the authors systematically researched literature published during the last 5 years (2019 – spring 2024) on the topic of 3D printed dosage forms. Besides all kinds of oral dosage forms ranging from tablets and capsules to films, pellets, etc., numerous reports were also identified on parenteral and cutaneous dosage forms and also rectal, vaginal, dental, intravesical, and ophthalmic preparations. In total, more than 500 publications were identified and grouped according to the site of administration, and an overview of the manuscripts is presented here. Furthermore, selected publications are described and discussed in more detail. The review highlights the very different approaches that are currently used in order to develop 3D printed dosage forms but also addresses remaining challenges.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115504"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next generation concepts in dermal delivery, theranostics, and preclinical testing 真皮递送、治疗和临床前测试的新一代概念

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115482

Sarah Hedtrich, Marcelo Calderón

引用次数: 0

Recent advances in 3D bioprinted neural models: A systematic review on the applications to drug discovery

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2025.115524

Amanda Orr , Farnoosh Kalantarnia , Shama Nazir , Behzad Bolandi , Dominic Alderson , Kerrin O’Grady , Mina Hoorfar , Lisa M. Julian , Stephanie M. Willerth

{"title":"Recent advances in 3D bioprinted neural models: A systematic review on the applications to drug discovery","authors":"Amanda Orr , Farnoosh Kalantarnia , Shama Nazir , Behzad Bolandi , Dominic Alderson , Kerrin O’Grady , Mina Hoorfar , Lisa M. Julian , Stephanie M. Willerth","doi":"10.1016/j.addr.2025.115524","DOIUrl":"10.1016/j.addr.2025.115524","url":null,"abstract":"<div><div>The design of neural tissue models with architectural and biochemical relevance to native tissues opens the way for the fundamental study and development of therapies for many disorders with limited treatment options. Here, we systematically review the most recent literature on 3D bioprinted neural models, including their potential for use in drug screening. Neural tissues that model the central nervous system (CNS) from the relevant literature are reviewed with comprehensive summaries of each study, and discussion of the model types, bioinks and additives, cell types used, bioprinted construct shapes and culture time, and the characterization methods used. In this review, we accentuate the lack of standardization among characterization methods to analyze the functionality (including chemical, metabolic and other pathways) and mechanical relevance of the 3D bioprinted constructs, and discuss this as a critical area for future exploration. These gaps must be addressed for this technology to be applied for effective drug screening applications, despite its enormous potential for rapid and efficient drug screening. The future of biomimetic, 3D printed neural tissues is promising and evaluation of the <em>in vivo</em> relevance on multiple levels should be sought to adequately compare model performance and develop viable treatment options for neurodegenerative diseases, or other conditions that affect the CNS.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"218 ","pages":"Article 115524"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current issues in optical monitoring of drug delivery via hair follicles 毛囊给药光学监测的现状

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115477

Yulia I. Svenskaya , Roman A. Verkhovskii , Sergey M. Zaytsev , Juergen Lademann , Elina A. Genina

{"title":"Current issues in optical monitoring of drug delivery via hair follicles","authors":"Yulia I. Svenskaya , Roman A. Verkhovskii , Sergey M. Zaytsev , Juergen Lademann , Elina A. Genina","doi":"10.1016/j.addr.2024.115477","DOIUrl":"10.1016/j.addr.2024.115477","url":null,"abstract":"<div><div>Drug delivery via hair follicles has attracted much research attention due to its potential to serve for both local and systemic therapeutic purposes. Recent studies on topical application of various particulate formulations have demonstrated a great role of this delivery route for targeting numerous cell populations located in skin and transporting the encapsulated drug molecules to the bloodstream. Despite a great promise of follicle-targeting carriers, their clinical implementation is very rare, mostly because of their poorer characterization compared to conventional topical dosage forms, such as ointments and creams, which have a history spanning over a century. Gathering as complete information as possible on the intrafollicular penetration depth, storage, degradation/metabolization profiles of such carriers and the release kinetics of drugs they contain, as well as their impact on skin health would significantly contribute to understanding the pros and cons of each carrier type and facilitate the selection of the most suitable candidates for clinical trials. Optical imaging and spectroscopic techniques are extensively applied to study dermal penetration of drugs. Current paper provides the state-of-the-art overview of techniques, which are used in optical monitoring of follicular drug delivery, with a special focus on non-invasive <em>in vivo</em> methods. It discusses key features, advantages and limitations of their use, as well as provide expert perspectives on future directions in this field.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115477"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142742743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra-tumoral bacteria in breast cancer and intervention strategies 乳腺癌肿瘤内细菌及其干预策略

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2025.115516

Ting Hou , Xiaoling Huang , Jiahui Lai , Dongfang Zhou

{"title":"Intra-tumoral bacteria in breast cancer and intervention strategies","authors":"Ting Hou , Xiaoling Huang , Jiahui Lai , Dongfang Zhou","doi":"10.1016/j.addr.2025.115516","DOIUrl":"10.1016/j.addr.2025.115516","url":null,"abstract":"<div><div>The microbiome, consisting of a wide range of both beneficial and harmful microorganisms, is vital to various physiological and pathological processes in the human body, including cancer pathogenesis. Tumor progression is often accompanied by the destruction of the vascular system, allowing bacteria to circulate into the tumor area and flourish in an immunosuppressive environment. Microbes are recognized as significant components of the tumor microenvironment. Recent research has increasingly focused on the role of intra-tumoral bacteria in the onset, progression, and treatment of breast cancer—the most prevalent cancer among women. This review elucidates the potential mechanisms by which intra-tumoral bacteria impact breast cancer and discusses different therapeutic approaches aimed at targeting these bacteria. It provides essential insights for enhancing existing treatment paradigms while paving the way for novel anticancer interventions. As our understanding of the microbiome’s intricate relationship with cancer deepens, it opens avenues for groundbreaking strategies that could redefine oncology.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115516"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D extrusion bioprinting of microbial inks for biomedical applications 用于生物医学应用的微生物油墨的3D挤出生物打印

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115505

Nicolas Burns , Arjun Rajesh , Avinash Manjula-Basavanna , Anna Duraj-Thatte

{"title":"3D extrusion bioprinting of microbial inks for biomedical applications","authors":"Nicolas Burns , Arjun Rajesh , Avinash Manjula-Basavanna , Anna Duraj-Thatte","doi":"10.1016/j.addr.2024.115505","DOIUrl":"10.1016/j.addr.2024.115505","url":null,"abstract":"<div><div>In recent years, the field of 3D bioprinting has witnessed the intriguing development of a new type of bioink known as microbial inks. Bioinks, typically associated with mammalian cells, have been reimagined to involve microbes, enabling many new applications beyond tissue engineering and regenerative medicine. This review presents the latest advancements in microbial inks, including their definition, types, composition, salient characteristics, and biomedical applications. Herein, microbes are genetically engineered to produce 1) extrudable bioink and 2) life-like functionalities such as self-regeneration, self-healing, self-regulation, biosynthesis, biosensing, biosignaling, biosequestration, etc. We also discuss some of the promising applications of 3D extrusion printed microbial inks, such as 1) drugs and probiotics delivery, 2) metabolite production, 3) tissue engineering, 4) bioremediation, 5) biosensors and bioelectronics, 6) biominerals and biocomposites, and 7) infectious disease modeling. Finally, we describe some of the current challenges of microbial inks that needs to be addressed in the coming years, to make a greater impact in health science and technology and many other fields.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115505"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeing through the skin: Optical methods for visualizing transdermal drug delivery with microneedles 透过皮肤看世界：用光学方法观察微针透皮给药情况

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115478

Benchaphorn Limcharoen , Supason Wanichwecharungruang , Wijit Banlunara , Maxim E. Darvin

{"title":"Seeing through the skin: Optical methods for visualizing transdermal drug delivery with microneedles","authors":"Benchaphorn Limcharoen , Supason Wanichwecharungruang , Wijit Banlunara , Maxim E. Darvin","doi":"10.1016/j.addr.2024.115478","DOIUrl":"10.1016/j.addr.2024.115478","url":null,"abstract":"<div><div>Optical methods play a pivotal role in advancing transdermal drug delivery research, particularly with the emergence of microneedle technology. This review presents a comprehensive analysis of optical methods used in studying transdermal drug delivery facilitated by microneedle technology. Beginning with an introduction to microneedle technology and skin anatomy and optical properties, the review explores the integration of optical methods for enhanced visualization. Optical imaging offers key advantages including real-time drug distribution visualization, non-invasive skin response monitoring, and quantitative drug penetration analysis. A spectrum of optical imaging modalities ranging from conventional dermoscopy and stereomicroscopy to advance techniques as fluorescence microscopy, laser scanning microscopy, <em>in vivo</em> imaging system, two-photon microscopy, fluorescence lifetime imaging microscopy, optical coherence tomography, Raman microspectroscopy, laser speckle contrast imaging, and photoacoustic microscopy is discussed. Challenges such as resolution and depth penetration limitations are addressed alongside potential breakthroughs and future directions in optical techniques development. The review underscores the importance of bridging the gap between preclinical and clinical studies, explores opportunities for integrating optical imaging and chemical sensing methods with drug delivery systems, and highlight the importance of non-invasive “optical biopsy” as a valuable alternative to conventional histology. Overall, this review provides insight into the role of optical methods in understanding transdermal drug delivery mechanisms with microneedles.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115478"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0