Advanced drug delivery reviews最新文献

Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging 突破靶向治疗的障碍：推进外泌体分离、工程和成像

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-22 DOI: 10.1016/j.addr.2025.115522

Anastasiya Kostyusheva, Eugenia Romano, Neng Yan, Manu Lopus, Andrey A. Zamyatnin, Alessandro Parodi

{"title":"Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging","authors":"Anastasiya Kostyusheva, Eugenia Romano, Neng Yan, Manu Lopus, Andrey A. Zamyatnin, Alessandro Parodi","doi":"10.1016/j.addr.2025.115522","DOIUrl":"https://doi.org/10.1016/j.addr.2025.115522","url":null,"abstract":"Exosomes have emerged as promising tools for targeted drug delivery in biomedical applications and medicine. This review delves into the scientific advancements, challenges, and future prospects specifically associated with these technologies. In this work, we trace the research milestones that led to the discovery and characterization of exosomes and extracellular vesicles, and discuss strategies for optimizing the synthetic yield and the loading of these particles with various therapeutics. In addition, we report the current major issues affecting the field and hampering the clinical translation of these technologies. Highlighting the pivotal role of imaging techniques, we explore how they drive exosome therapy and development by offering insights into biodistribution and cellular trafficking dynamics. Methodologies for vesicle isolation, characterization, loading, and delivery mechanisms are thoroughly examined, alongside strategies aimed at enhancing their therapeutic efficacy. Special emphasis was dedicated to their therapeutic properties, particularly to their ability to deliver biologics into the cytoplasm. Furthermore, we delve into the intricate balance between surface modifications and targeting properties including also transgenic methods aimed at their functionalization and visualization within biological systems. This review underscores the transformative potential of these carriers in targeted drug delivery and identifies crucial areas for further research and clinical translation.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"11 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence lifetime imaging in drug delivery research 荧光寿命成像在给药研究中的应用

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-21 DOI: 10.1016/j.addr.2025.115521

Yiqing Lu, Parinaz Jabbari, Anton Mukhamedshin, Andrei V. Zvyagin

引用次数: 0

Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos 用于监测药物输送的光片荧光显微镜：揭开胚胎发育阶段的神秘面纱

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-20 DOI: 10.1016/j.addr.2025.115520

Gagan Raju, Aymeric Le Gratiet, Giuseppe Sancataldo, Guan-Yu Zhuo, Yury Kistenev, Subir Das, Ajeetkumar Patil, Nirmal Mazumder

{"title":"Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos","authors":"Gagan Raju, Aymeric Le Gratiet, Giuseppe Sancataldo, Guan-Yu Zhuo, Yury Kistenev, Subir Das, Ajeetkumar Patil, Nirmal Mazumder","doi":"10.1016/j.addr.2025.115520","DOIUrl":"https://doi.org/10.1016/j.addr.2025.115520","url":null,"abstract":"Light sheet fluorescence microscopy (LSFM) has emerged as a transformative imaging technique in the study of drug delivery and embryonic development, offering high-resolution, real-time visualization with minimal phototoxicity. This review examines the application of LSFM in tracking drug pharmacokinetics, tissue-specific targeting, and drug efficacy during critical phases of embryonic development. Recent advancements in fluorescent labeling and machine learning integration have enabled more precise monitoring of drug release, distribution, and interaction with developing tissues. The ability of LSFM to capture long-term dynamics at single-cell resolution has revolutionized drug discovery, especially in nanomedicine and targeted therapies. By integrating LSFM with multimodal imaging and AI-driven data analysis, researchers are now better equipped to explore complex biological processes and optimize drug delivery in a highly controlled, minimally invasive manner. Finally, the review highlights the pivotal role of LSFM in advancing drug delivery research, addressing existing challenges, and unlocking new frontiers in clinical applications.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"9 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142990853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra-tumoral bacteria in breast cancer and intervention strategies 乳腺癌肿瘤内细菌及其干预策略

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-17 DOI: 10.1016/j.addr.2025.115516

Ting Hou, Xiaoling Huang, Jiahui Lai, Dongfang Zhou

引用次数: 0

Drug delivery systems for treating neurodevelopmental disorders. 治疗神经发育障碍的给药系统。

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-01 Epub Date: 2024-11-17 DOI: 10.1016/j.addr.2024.115473

Boaz Barak, Paolo Decuzzi

引用次数: 0

Editorial: Super-resolution imaging of sub-cellular dynamics of drug molecules. 药物分子亚细胞动态超分辨率成像。

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-01 Epub Date: 2024-09-14 DOI: 10.1016/j.addr.2024.115455

Qixin Chen, Jiajie Diao

引用次数: 0

3D printing of pharmaceutical dosage forms: Recent advances and applications 药物剂型的3D打印：最新进展和应用

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-12-19 DOI: 10.1016/j.addr.2024.115504

Auel Tobias, Mentrup Aaron Felix Christofer, Oldfield Lee Roy, Seidlitz Anne

引用次数: 0

3D extrusion bioprinting of microbial inks for biomedical applications 用于生物医学应用的微生物油墨的3D挤出生物打印

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-12-19 DOI: 10.1016/j.addr.2024.115505

Nicolas Burns, Arjun Rajesh, Avinash Manjula-Basavanna, Anna Duraj-Thatte

{"title":"3D extrusion bioprinting of microbial inks for biomedical applications","authors":"Nicolas Burns, Arjun Rajesh, Avinash Manjula-Basavanna, Anna Duraj-Thatte","doi":"10.1016/j.addr.2024.115505","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115505","url":null,"abstract":"In recent years, the field of 3D bioprinting has witnessed the intriguing development of a new type of bioink known as microbial inks. Bioinks, typically associated with mammalian cells, have been reimagined to involve microbes, enabling many new applications beyond tissue engineering and regenerative medicine. This review presents the latest advancements in microbial inks, including their definition, types, composition, salient characteristics, and biomedical applications. Herein, microbes are genetically engineered to produce 1) extrudable bioink and 2) life-like functionalities such as self-regeneration, self-healing, self-regulation, biosynthesis, biosensing, biosignaling, biosequestration, etc. We also discuss some of the promising applications of 3D extrusion printed microbial inks, such as 1) drugs and probiotics delivery, 2) metabolite production, 3) tissue engineering, 4) bioremediation, 5) biosensors and bioelectronics, 6) biominerals and biocomposites, and 7) infectious disease modeling. Finally, we describe some of the current challenges of microbial inks that needs to be addressed in the coming years, to make a greater impact in health science and technology and many other fields.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"87 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of pharmacometrics in drug development 药物计量学在药物开发中的应用

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-12-19 DOI: 10.1016/j.addr.2024.115503

Yuan Xiong, Mahesh N. Samtani, Daniele Ouellet

{"title":"Application of pharmacometrics in drug development","authors":"Yuan Xiong, Mahesh N. Samtani, Daniele Ouellet","doi":"10.1016/j.addr.2024.115503","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115503","url":null,"abstract":"The last two decades have witnessed profound changes in how advanced computational tools can help leverage tons of data to improve our knowledge, and ultimately reduce cost and increase productivity in drug development. Pharmacometrics has demonstrated its impact through model-informed drug development (MIDD) approaches. It is now an indispensable component throughout the whole continuum of drug discovery, development, regulatory review, and approval. Today, applications of pharmacometrics are common in designing better trials and accelerating evidence-based decisions. Newly emerging technologies, especially those from data and computer sciences, are being integrated with existing computational tools used in the pharmaceutical industry at a remarkably fast pace. The new challenges faced by the pharmacometrics community are not what or how to contribute, but which optimal MIDD strategy should be adopted to maximize its value in the decision-making process. While we are embracing new innovative approaches and tools, this article discusses how a variety of existing modeling tools, with differentiated advantages and focus, can work in concert to inform drug development.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"7 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring kinetic processes of drugs and metabolites: Surface-enhanced Raman spectroscopy 监测药物和代谢物的动力学过程：表面增强拉曼光谱

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-12-13 DOI: 10.1016/j.addr.2024.115483

Zhewen Luo, Haoran Chen, Xinyuan Bi, Jian Ye

{"title":"Monitoring kinetic processes of drugs and metabolites: Surface-enhanced Raman spectroscopy","authors":"Zhewen Luo, Haoran Chen, Xinyuan Bi, Jian Ye","doi":"10.1016/j.addr.2024.115483","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115483","url":null,"abstract":"Monitoring the kinetic changes of drugs and metabolites plays a crucial role in fundamental research, preclinical and clinical application. Raman spectroscopy (RS) is regarded as a fingerprinting technique that can reflect molecular structures but limited in applications due to poor sensitivity. Surface-enhanced Raman spectroscopy (SERS) significantly amplifies the detection sensitivity by plasmonic substrates, facilitating the identification and quantification of small molecules in biological samples, such as serum, urine, and living cells. This review will focus on advances in how SERS has been utilized to monitor the dynamic processes of small molecule drugs and metabolites in recent years. We first provide readers with a comprehensive overview of the mechanism and practical considerations of SERS, including enhancement theory, substrate design, sample pretreatment, molecule–substrate interactions and spectral analysis. Then we describe the latest advances in SERS for the detection and analysis of metabolites and drugs in cells, dynamic monitoring of drug in various biological matrices, and metabolic profiling for health assessment in biological fluids. We believe that high-performance SERS substrates, standardized technical regulations, and artificial intelligence spectral analysis will boost sensitive, accurate, reproducible, and universal molecular detection in the future. We hoped this review could inspire researchers working in related fields to better understand and utilize SERS for the analytical detection of drugs and metabolites.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"1 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0