Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies

IF 15.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2025-07-09 DOI:10.1016/j.addr.2025.115647

Taymin du Toit-Thompson, Lionel Leck, Josef Gillson, Nick Pavlakis, Anthony J. Gill, Jaswinder S. Samra, Anubhav Mittal, Sumit Sahni

引用次数: 0

Abstract

Pancreatic cancer (PC) is one of the deadliest types of cancer, with a 5-year survival rate of ∼12.5 %. It is expected to become the second leading cause of cancer-related deaths by 2030. Despite recent advances in treatment options by advent of various targeted and immunotherapies, their benefits have not been actualized for PC patients and chemotherapy remains the mainstay systemic therapeutic option for these patients. However, the majority of PC tumours have a highly chemo-resistant phenotype, leading to therapeutic failure. This review provides a comprehensive overview of the established mechanisms related to chemoresistance in PC and provides insight into emerging theories, including the potential role of the microbiome in modulating therapeutic responsiveness. It further discusses potential opportunities to explore to overcome this critical clinical problem.

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克服胰腺癌治疗耐药：挑战和新兴策略

胰腺癌（PC）是最致命的癌症之一，其5年生存率为12.5% %。预计到2030年，它将成为癌症相关死亡的第二大原因。尽管最近各种靶向和免疫疗法在治疗选择方面取得了进展，但它们的益处尚未在PC患者中实现，化疗仍然是这些患者的主要全身治疗选择。然而，大多数PC肿瘤具有高度耐药表型，导致治疗失败。这篇综述提供了与PC化疗耐药相关的已建立机制的全面概述，并提供了对新兴理论的见解，包括微生物组在调节治疗反应性中的潜在作用。它进一步讨论了探索克服这一关键临床问题的潜在机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.