Progress of tumor-resident intracellular bacteria for cancer therapy

IF 15.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2024-10-09 DOI:10.1016/j.addr.2024.115458

Peng Bao, Xian-Zheng Zhang

引用次数: 0

Abstract

Emerging studies have disclosed the pivotal role of cancer-associated microbiota in supporting cancer development, progression and dissemination, with the in-depth comprehending of tumor microenvironment. In particular, certain invasive bacteria that hide in various cells within the tumor tissues can render assistance to tumor growth and invasion through intricate mechanisms implicated in multiple branches of cancer biology. Thus, tumor-resident intracellular microbes are anticipated as next-generation targets for oncotherapy. This review is intended to delve into these internalized bacteria-driven cancer-promoting mechanisms and explore diversified antimicrobial therapeutic strategies to counteract the detrimental impact caused by these intruders, thereby improving therapeutic benefit of antineoplastic therapy.

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将肿瘤驻留细胞内细菌用于癌症治疗的进展

随着对肿瘤微环境的深入了解，新的研究揭示了癌症相关微生物群在支持癌症发展、恶化和扩散方面的关键作用。特别是，隐藏在肿瘤组织内各种细胞中的某些侵袭性细菌可通过与癌症生物学多个分支相关的复杂机制，为肿瘤的生长和侵袭提供帮助。因此，驻留在肿瘤细胞内的微生物有望成为下一代肿瘤治疗的靶点。本综述旨在深入探讨这些内化细菌驱动的促癌机制，并探索多样化的抗微生物治疗策略，以抵消这些入侵者造成的不利影响，从而提高抗肿瘤疗法的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.