Advanced drug delivery reviews最新文献_第6页

Breaking the final barrier: Evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome 打破最后的障碍：脂质纳米颗粒中阳离子和可电离脂质结构的演变，以逃离内质体。

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-09-16 DOI: 10.1016/j.addr.2024.115446

Kaitlin Mrksich , Marshall S. Padilla , Michael J. Mitchell

{"title":"Breaking the final barrier: Evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome","authors":"Kaitlin Mrksich , Marshall S. Padilla , Michael J. Mitchell","doi":"10.1016/j.addr.2024.115446","DOIUrl":"10.1016/j.addr.2024.115446","url":null,"abstract":"<div><div>In the past decade, nucleic acid therapies have seen a boon in development and clinical translation largely due to advances in nanotechnology that have enabled their safe and targeted delivery. Nanoparticles can protect nucleic acids from degradation by serum enzymes and can facilitate entry into cells. Still, achieving endosomal escape to allow nucleic acids to enter the cytoplasm has remained a significant barrier, where less than 5% of nanoparticles within the <em>endo</em>-lysosomal pathway are able to transfer their cargo to the cytosol. Lipid-based drug delivery vehicles, particularly lipid nanoparticles (LNPs), have been optimized to achieve potent endosomal escape, and thus have been the vector of choice in the clinic as demonstrated by their utilization in the COVID-19 mRNA vaccines. The success of LNPs is in large part due to the rational design of lipids that can specifically overcome endosomal barriers. In this review, we chart the evolution of lipid structure from cationic lipids to ionizable lipids, focusing on structure–function relationships, with a focus on how they relate to endosomal escape. Additionally, we examine recent advancements in ionizable lipid structure as well as discuss the future of lipid design.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"214 ","pages":"Article 115446"},"PeriodicalIF":15.2,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of MIDD to accelerate the development of anti-infectives: Current status and future perspectives 应用 MIDD 加速抗感染药物的开发：现状与未来展望

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-09-12 DOI: 10.1016/j.addr.2024.115447

Wen Yao Mak , Qingfeng He , Wenyu Yang , Nuo Xu , Aole Zheng , Min Chen , Jiaying Lin , Yufei Shi , Xiaoqiang Xiang , Xiao Zhu

{"title":"Application of MIDD to accelerate the development of anti-infectives: Current status and future perspectives","authors":"Wen Yao Mak , Qingfeng He , Wenyu Yang , Nuo Xu , Aole Zheng , Min Chen , Jiaying Lin , Yufei Shi , Xiaoqiang Xiang , Xiao Zhu","doi":"10.1016/j.addr.2024.115447","DOIUrl":"10.1016/j.addr.2024.115447","url":null,"abstract":"<div><p>This review examines the role of model-informed drug development (MIDD) in advancing antibacterial and antiviral drug development, with an emphasis on the inclusion of host system dynamics into modeling efforts. Amidst the growing challenges of multidrug resistance and diminishing market returns, innovative methodologies are crucial for continuous drug discovery and development. The MIDD approach, with its robust capacity to integrate diverse data types, offers a promising solution. In particular, the utilization of appropriate modeling and simulation techniques for better characterization and early assessment of drug resistance are discussed. The evolution of MIDD practices across different infectious disease fields is also summarized, and compared to advancements achieved in oncology. Moving forward, the application of MIDD should expand into host system dynamics as these considerations are critical for the development of “live drugs” (e.g. chimeric antigen receptor T cells or bacteriophages) to address issues like antibiotic resistance or latent viral infections.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"214 ","pages":"Article 115447"},"PeriodicalIF":15.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of nanoparticle deformability on multiscale biotransport 纳米粒子变形性对多尺度生物传输的影响

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-08-31 DOI: 10.1016/j.addr.2024.115445

Hytham H. Gadalla , Zhongyue Yuan , Ziang Chen , Faisal Alsuwayyid , Subham Das , Harsa Mitra , Arezoo M. Ardekani , Ryan Wagner , Yoon Yeo

{"title":"Effects of nanoparticle deformability on multiscale biotransport","authors":"Hytham H. Gadalla , Zhongyue Yuan , Ziang Chen , Faisal Alsuwayyid , Subham Das , Harsa Mitra , Arezoo M. Ardekani , Ryan Wagner , Yoon Yeo","doi":"10.1016/j.addr.2024.115445","DOIUrl":"10.1016/j.addr.2024.115445","url":null,"abstract":"<div><p>Deformability is one of the critical attributes of nanoparticle (NP) drug carriers, along with size, shape, and surface properties. It affects various aspects of NP biotransport, ranging from circulation and biodistribution to interactions with biological barriers and target cells. Recent studies report additional roles of NP deformability in biotransport processes, including protein corona formation, intracellular trafficking, and organelle distribution. This review focuses on the literature published in the past five years to update our understanding of NP deformability and its effect on NP biotransport. We introduce different methods of modulating and evaluating NP deformability and showcase recent studies that compare a series of NPs in their performance in biotransport events at all levels, highlighting the consensus and disagreement of the findings. It concludes with a perspective on the intricacy of systematic investigation of NP deformability and future opportunities to advance its control toward optimal drug delivery.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"213 ","pages":"Article 115445"},"PeriodicalIF":15.2,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Model-informed precision dosing: State of the art and future perspectives 基于模型的精确配料：技术现状与未来展望。

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-08-17 DOI: 10.1016/j.addr.2024.115421

I.K. Minichmayr , E. Dreesen , M. Centanni , Z. Wang , Y. Hoffert , L.E. Friberg , S.G. Wicha

{"title":"Model-informed precision dosing: State of the art and future perspectives","authors":"I.K. Minichmayr , E. Dreesen , M. Centanni , Z. Wang , Y. Hoffert , L.E. Friberg , S.G. Wicha","doi":"10.1016/j.addr.2024.115421","DOIUrl":"10.1016/j.addr.2024.115421","url":null,"abstract":"<div><div>Model-informed precision dosing (MIPD) stands as a significant development in personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves beyond traditional therapeutic drug monitoring (TDM) by integrating mathematical predictions of dosing, and considering patient-specific factors (patient characteristics, drug measurements) as well as different sources of variability. For this purpose, rigorous model qualification is required for the application of MIPD in patients. This review delves into new methods in model selection and validation, also highlighting the role of machine learning in improving MIPD, the utilization of biosensors for real-time monitoring, as well as the potential of models integrating biomarkers for efficacy or toxicity for precision dosing. The clinical evidence of TDM and MIPD is discussed for various medical fields including infection medicine, oncology, transplant medicine, and inflammatory bowel diseases, thereby underscoring the role of pharmacokinetics/pharmacodynamics and specific biomarkers. Further research, particularly randomized clinical trials, is warranted to corroborate the value of MIPD in enhancing patient outcomes and advancing personalized medicine.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"215 ","pages":"Article 115421"},"PeriodicalIF":15.2,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug delivery strategies for local immunomodulation in transplantation: Bridging the translational gap 移植中局部免疫调节的给药策略：缩小转化差距。

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-08-13 DOI: 10.1016/j.addr.2024.115429

Afsana Naaz , Heth R. Turnquist , Vijay S. Gorantla , Steven R. Little

引用次数: 0

Advances in the design and delivery of RNA vaccines for infectious diseases 设计和提供治疗传染病的 RNA 疫苗的进展。

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-08-05 DOI: 10.1016/j.addr.2024.115419

Abhijeet Girish Lokras , Thomas Rønnemoes Bobak , Saahil Sandeep Baghel , Federica Sebastiani , Camilla Foged

{"title":"Advances in the design and delivery of RNA vaccines for infectious diseases","authors":"Abhijeet Girish Lokras , Thomas Rønnemoes Bobak , Saahil Sandeep Baghel , Federica Sebastiani , Camilla Foged","doi":"10.1016/j.addr.2024.115419","DOIUrl":"10.1016/j.addr.2024.115419","url":null,"abstract":"<div><p>RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of global significance, <em>e.g.</em>, infectious diseases. The highly successful messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed at record speed during the coronavirus disease 2019 pandemic. A consequence of this is exceptionally shortened vaccine development times, which in combination with adaptability makes the RNA vaccine technology highly attractive against infectious diseases and for pandemic preparedness. Here, we review state of the art in the design and delivery of RNA vaccines for infectious diseases based on different RNA modalities, including linear mRNA, self-amplifying RNA, <em>trans</em>-amplifying RNA, and circular RNA. We provide an overview of the clinical pipeline of RNA vaccines for infectious diseases, and present analytical procedures, which are paramount for characterizing quality attributes and guaranteeing their quality, and we discuss future perspectives for using RNA vaccines to combat pathogens beyond SARS-CoV-2.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"213 ","pages":"Article 115419"},"PeriodicalIF":15.2,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0169409X24002412/pdfft?md5=d95ea72925743ff2f59eadf7fc5ec9a0&pid=1-s2.0-S0169409X24002412-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light in evaluation of molecular diffusion in tissues: Discrimination of pathologies 评估组织中分子扩散的光：病理鉴别

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-08-02 DOI: 10.1016/j.addr.2024.115420

Luís R. Oliveira , Maria R. Pinheiro , Daria K. Tuchina , Polina A. Timoshina , Maria I. Carvalho , Luís M. Oliveira

{"title":"Light in evaluation of molecular diffusion in tissues: Discrimination of pathologies","authors":"Luís R. Oliveira , Maria R. Pinheiro , Daria K. Tuchina , Polina A. Timoshina , Maria I. Carvalho , Luís M. Oliveira","doi":"10.1016/j.addr.2024.115420","DOIUrl":"10.1016/j.addr.2024.115420","url":null,"abstract":"<div><p>The evaluation of the diffusion properties of different molecules in tissues is a subject of great interest in various fields, such as dermatology/cosmetology, clinical medicine, implantology and food preservation. In this review, a discussion of recent studies that used kinetic spectroscopy measurements to evaluate such diffusion properties in various tissues is made. By immersing <em>ex vivo</em> tissues in agents or by topical application of those agents <em>in vivo</em>, their diffusion properties can be evaluated by kinetic collimated transmittance or diffuse reflectance spectroscopy. Using this method, recent studies were able to discriminate the diffusion properties of agents between healthy and diseased tissues, especially in the cases of cancer and diabetes mellitus. In the case of cancer, it was also possible to evaluate an increase of 5% in the mobile water content from the healthy to the cancerous colorectal and kidney tissues. Considering the application of some agents to living organisms or food products to protect them from deterioration during low temperature preservation (cryopreservation), and knowing that such agent inclusion may be reversed, some studies in these fields are also discussed. Considering the broadband application of the optical spectroscopy evaluation of the diffusion properties of agents in tissues and the physiological diagnostic data that such method can acquire, further studies concerning the optimization of fruit sweetness or evaluation of poison diffusion in tissues or antidote application for treatment optimization purposes are indicated as future perspectives.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"212 ","pages":"Article 115420"},"PeriodicalIF":15.2,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0169409X24002424/pdfft?md5=b8367e26b483709981c036dc2434830a&pid=1-s2.0-S0169409X24002424-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmability and biomedical utility of intrinsically-disordered protein polymers 内在有序蛋白质聚合物的可编程性和生物医学用途。

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-07-31 DOI: 10.1016/j.addr.2024.115418

Maria Camila Giraldo-Castaño, Kai A. Littlejohn, Alexa Regina Chua Avecilla, Natalia Barrera-Villamizar, Felipe Garcia Quiroz

{"title":"Programmability and biomedical utility of intrinsically-disordered protein polymers","authors":"Maria Camila Giraldo-Castaño, Kai A. Littlejohn, Alexa Regina Chua Avecilla, Natalia Barrera-Villamizar, Felipe Garcia Quiroz","doi":"10.1016/j.addr.2024.115418","DOIUrl":"10.1016/j.addr.2024.115418","url":null,"abstract":"<div><p>Intrinsically disordered proteins (IDPs) exhibit molecular-level conformational dynamics that are functionally harnessed across a wide range of fascinating biological phenomena. The low sequence complexity of IDPs has led to the design and development of intrinsically-disordered protein polymers (IDPPs), a class of engineered repeat IDPs with stimuli-responsive properties. The perfect repetitive architecture of IDPPs allows for repeat-level encoding of tunable protein functionality. Designer IDPPs can be modeled on endogenous IDPs or engineered de novo as protein polymers with dual biophysical and biological functionality. Their properties can be rationally tailored to access enigmatic IDP biology and to create programmable smart biomaterials. With the goal of inspiring the bioengineering of multifunctional IDP-based materials, here we synthesize recent multidisciplinary progress in programming and exploiting the bio-functionality of IDPPs and IDPP-containing proteins. Collectively, expanding beyond the traditional sequence space of extracellular IDPs, emergent sequence-level control of IDPP functionality is fueling the bioengineering of self-assembling biomaterials, advanced drug delivery systems, tissue scaffolds, and biomolecular condensates —genetically encoded organelle-like structures. Looking forward, we emphasize open challenges and emerging opportunities, arguing that the intracellular behaviors of IDPPs represent a rich space for biomedical discovery and innovation. Combined with the intense focus on IDP biology, the growing landscape of IDPPs and their biomedical applications set the stage for the accelerated engineering of high-value biotechnologies and biomaterials.</p></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"212 ","pages":"Article 115418"},"PeriodicalIF":15.2,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug delivery technologies for autoimmunity therapies 用于自身免疫疗法的给药技术。

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-07-27 DOI: 10.1016/j.addr.2024.115412

Ajay S. Thatte, Jessica D. Weaver, Ryan Pearson, Michael J. Mitchell

引用次数: 0

Precise subcellular targeting approaches for organelle-related disorders 针对细胞器相关疾病的精确亚细胞靶向方法。

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-07-19 DOI: 10.1016/j.addr.2024.115411

Gayong Shim , Yu Seok Youn

引用次数: 0