Advanced drug delivery reviews最新文献

{"title":"Circadian attributes of neurological and psychiatric disorders as basis for their medication chronotherapy","authors":"Sepideh Khoshnevis ,&nbsp;Michael H. Smolensky ,&nbsp;Shahab Haghayegh","doi":"10.1016/j.addr.2025.115576","DOIUrl":"10.1016/j.addr.2025.115576","url":null,"abstract":"<div><div>This review focuses on (i) 24 h patterns in the symptom intensity of common neurologic and psychiatric disorders and (ii) medications prescribed for their management that have a recommended administration time or schedule, presumably to potentiate desired and minimize undesired effects and by definition qualify them as chronotherapies. Predictable-in-time patterning of symptoms is exhibited by many neurologic –– headaches, multiple sclerosis, neurogenic orthostatic hypotension, neuropathic pain, Parkinson’s disease, epileptic seizure, attention deficit hyperactivity, Alzheimer’s disease – and psychiatric – eating, depressive, obsessive–compulsive, post-traumatic stress, anxiety, and panic – disorders, due either to circadian rhythms of disease pathophysiology or inadequacies of medication-delivery systems. Circadian disruption and circadian misalignment of the sleep-wake and other 24 h rhythms plus late chronotype are characteristic of many of these disorders, suggesting involvement in the mechanisms or consequence of their pathology or as an adverse effect of therapy, especially when administered at an inappropriate biological time. The Prescribers’ Digital Reference, a compendium of all prescription medications approved for marketing in the US, reveals 65 of them are utilized to manage neurologic and psychiatric disorders by a specified time-of-day or an asymmetrical interval or strength of dose schedule, presumably to optimize beneficial and minimize adverse effects, thereby qualifying them as chronotherapies. Overall, the contents of this review are intended to inform the development of future chronotherapies that incorporate state-of-the-art drug-delivery systems to improve management of neurologic and psychiatric disorders and associated circadian malalignment and disruption.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"223 ","pages":"Article 115576"},"PeriodicalIF":15.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implantable systems for neurological chronotherapy","authors":"Seung Ho Lee ,&nbsp;Roemer Pott Hofstede ,&nbsp;Adrián Noriega de la Colina ,&nbsp;John H. Gunton ,&nbsp;Joshua D. Bernstock ,&nbsp;Giovanni Traverso","doi":"10.1016/j.addr.2025.115574","DOIUrl":"10.1016/j.addr.2025.115574","url":null,"abstract":"<div><div>Implantable systems for neurological chronotherapy are poised to revolutionize the treatment of central nervous system diseases and disorders. These devices enable precise, time-controlled drug delivery aligned with the body’s circadian rhythms, optimizing therapeutic outcomes. By bypassing the blood–brain barrier, they achieve high local drug concentrations while minimizing systemic side effects, offering significant advantages for conditions where traditional therapies often fall short.</div><div>Platforms like SynchroMed II and CraniUS showcase this innovation, providing programmable delivery for conditions such as epilepsy and glioblastoma, with customizable profiles ranging from continuous infusion to timed bolus administration. Preclinical and clinical studies underscore the efficacy of aligning drug delivery with circadian rhythms, enhancing outcomes in chrono-chemotherapy and anti-epileptic treatments.</div><div>Despite their promise, challenges remain, including the invasiveness of implantation within the brain, device longevity, synchronization complexities, and cost(s). Accordingly, this review explores the current state of implantable neurological systems that may be leveraged for chronotherapy, their applications, limitations, and potential to transform neurological disease/disorder management.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"221 ","pages":"Article 115574"},"PeriodicalIF":15.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal NAP (Davunetide): Neuroprotection and circadian rhythmicity","authors":"Artur Galushkin,&nbsp;Illana Gozes","doi":"10.1016/j.addr.2025.115573","DOIUrl":"10.1016/j.addr.2025.115573","url":null,"abstract":"<div><div>In this review we examine the neuroprotective potential of NAP (davunetide), a small peptide derived from Activity-Dependent Neuroprotective Protein (ADNP), in the context of neurodevelopmental and neurodegenerative disorders. ADNP, a protein essential for brain development and function, is associated with tauopathy-related diseases, such as Alzheimer’s Disease (AD), and circadian rhythm regulation. NAP enhances microtubule stability and prevents tauopathy. In preclinical studies, NAP shows promise in improving cognitive performance and correcting behavioral deficits in different models. Clinical studies on NAP (davunetide) administered via intranasal delivery have demonstrated its safety, favorable bioavailability, and potential efficacy in improving cognitive function, making it a viable therapeutic option. In the pure tauopathy, progressive supranuclear palsy, NAP (davunetide) significantly slowed disease progression in women in a phase II-III clinical trial. Additionally, the complex interactions between ADNP, associated pathways, and circadian regulation and the extensive NAP compensation upon ADNP deficiency attest to further clinical development. Thus, NAP is an example of a reductionist approach in drug delivery, replacing/enhancing the critical large ADNP-related pathways including dysregulated microtubules and tauopathy with a small brain bioavailable investigational drug, davunetide.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115573"},"PeriodicalIF":15.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook","authors":"Rhearne Ryan ,&nbsp;Mathew N. Leslie ,&nbsp;Patrick He ,&nbsp;Paul M. Young ,&nbsp;Camilla M. Hoyos ,&nbsp;Hui Xin Ong ,&nbsp;Daniela Traini","doi":"10.1016/j.addr.2025.115575","DOIUrl":"10.1016/j.addr.2025.115575","url":null,"abstract":"<div><div>Synchronisation of the suprachiasmatic nucleus (SCN) driven endogenous clock, located within the central nervous system (CNS), and exogenous time cues, is essential for maintaining circadian rhythmicity, homeostasis and overall wellbeing. Disordered circadian rhythms have been associated with various conditions, inclusive of neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. Traditional pharmacological approaches to circadian dysfunction in neurodegenerative disorders have primarily focused on oral drug delivery. Oral medications often face challenges in achieving the necessary systemic circulation to effectively bypass the blood brain barrier (BBB) and reach the CNS, primarily due to low or variable bioavailability. Advancements in non-invasive delivery methods, such as orally inhaled and intranasal formulations, present promising alternatives for targeting the CNS. Orally inhaled and intranasal drug delivery allows for medications to rapidly achieve high systemic circulation through increased bioavailability and fast onset of action. Additionally, intranasal delivery allows for therapies to bypass the BBB through the olfactory or trigeminal nerve pathways to directly enter the CNS. This review assesses the potential for orally inhaled and intranasal therapies to treat circadian disorders in neurodegenerative conditions. In addition, this review will explore melatonin as an example of enhancing therapeutic outcomes by adopting inhaled or intranasal drug delivery formulations to improve drug absorption and target circadian disorder more effectively.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115575"},"PeriodicalIF":15.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Devices to overcome the buccal mucosal barrier to administer therapeutic peptides","authors":"Sahil Malhotra ,&nbsp;Thomas Lijnse ,&nbsp;Eoin O’ Cearbhaill ,&nbsp;David J. Brayden","doi":"10.1016/j.addr.2025.115572","DOIUrl":"10.1016/j.addr.2025.115572","url":null,"abstract":"<div><div>Peptide therapeutics are important in healthcare owing to their high target specificity, therapeutic efficacy, and relatively low side effect profile. Injections of these agents have improved the<!--> <!-->treatment of chronic diseases including autoimmune, metabolic disorders, and cancer. However, their administration via injections can prove a barrier to patient acceptability of treatments. While oral delivery of these molecules is preferable, oral peptide formulations are associated with limited bioavailability due to degradation in the intestine and low epithelial permeability. Buccal administration of peptides is a potential alternative to injections and oral formulations. Similar to the oral route, the buccal route can promote better patient adherence to dosing regimens, along with the added advantages of not requiring restriction on food or drink consumption before and after administration, as well as avoidance of the liver first-pass metabolism. However, like oral, effective buccal absorption of peptides is still challenging due to the high epithelial permeability barrier. We present a multidisciplinary approach to understanding the buccal physiological barrier to macromolecule permeation and discuss how engineered devices may overcome it. Selected examples of buccal devices can facilitate fast and efficient macromolecule absorption through multiple mechanisms including physical disruption of epithelia, convection-based mass transfer, and a combination of physicochemical strategies. Importantly, minimally invasive devices can be self-applied and are associated with the maintenance of the barrier after exposure. We analysed the critical attributes that are required for<!--> <!-->the clinical translation of buccal peptide administration devices. These include performance-driven device development, manufacturing features, patient acceptability, and commercial viability.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115572"},"PeriodicalIF":15.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating the electronic structure of graphdiyne-based nanomaterials for engineering nano-bio interfaces in biomedical applications","authors":"Hui Wang ,&nbsp;Xiaoyu Zhang ,&nbsp;Jing Liu ,&nbsp;Chunying Chen","doi":"10.1016/j.addr.2025.115570","DOIUrl":"10.1016/j.addr.2025.115570","url":null,"abstract":"<div><div>Graphdiyne (GDY), a two-dimensional (2D) carbon allotrope featuring a unique electronic structure, has attracted considerable attention due to its outstanding properties and potential applications in various fields, particularly in biomedicine due to its exceptional surface area, tunable electronic structure, and biocompatibility. Although promising, this field is still in the proof-of-concept stage due to incomplete understanding of the effects of structural regulation, particularly electronic structure, of GDY-based nanomaterials on their nano-bio interfaces, which seriously hinders the research of GDY-based nanomaterials in the biomedical field. To provide a comprehensive understanding of the relationship between electronic structures and nano-bio interfaces, this review focuses on the modulation of the electronic structure of GDY-based nanomaterials and its implications for engineering nano-bio interfaces for biomedical applications. Firstly, we delve into the intrinsic electronic properties of GDY, including its bandgap tunability and high carrier mobility, which are critical for its functionality in biomedical applications. We then discuss strategies for modulating these properties through oxidation, nonmetallic doping, covalent modification, and metal loading, aiming to optimize the electronic structure of GDY-based nanomaterials for superior performance in specific biomedical contexts, such as biomedical imaging, surface and interface catalysis, free radical scavenging, and drug delivery. Furthermore, we provide an overview of the methodologies for the investigation of these electronic properties, including theoretical simulation, characterization techniques, and real-time analysis of electron transfer at the nano-bio interfaces, highlighting their roles in advancing our understanding and guiding the design of novel GDY-based materials. Finally, this review provides an outlook on future research directions aimed at further optimizing the design of GDY-based nanomaterials and nano-bio interfaces, emphasizing the need for interdisciplinary collaboration to overcome current challenges and to fully realize the potential of GDY-based nanomaterials in biomedical applications. These principles are anticipated to facilitate the future development and clinical translation of precise, safe, and effective nanomedicines with intelligent theranostic features.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115570"},"PeriodicalIF":15.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography for noninvasive monitoring of drug delivery","authors":"Salavat R. Aglyamov,&nbsp;Kirill V. Larin","doi":"10.1016/j.addr.2025.115571","DOIUrl":"10.1016/j.addr.2025.115571","url":null,"abstract":"<div><div>Optical Coherence Tomography (OCT) has revolutionized various medical imaging and diagnostics fields, offering unprecedented insights into the microstructural compositions of biological tissues. In recent years, OCT applications have been extended to noninvasive drug delivery monitoring, which is a critical aspect of many therapeutic procedures and pharmacokinetic studies. Such an extension is strongly enhanced by the inherent combination with 3D anatomical images provided by OCT. This review presents an overview of the principles of OCT technology, its functional extensions for drug delivery systems, and its advancements in monitoring therapeutic interventions. We discuss its advantages over traditional imaging modalities in terms of spatial resolution, depth penetration, and real-time capabilities. The paper highlights significant studies that have utilized OCT for the visualization and quantification of drug delivery processes, including the diffusion of injectable formulations in ocular tissues and the permeation of topical drugs through the skin. In the review, we focused on the latest OCT applications, including OCT-guided drug injection, topical drug delivery monitoring, application of OCT in inhaled drug delivery systems, and the integration of OCT with other imaging modalities.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115571"},"PeriodicalIF":15.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles targeting the central circadian clock: Potential applications for neurological disorders","authors":"Marion Le Meur ,&nbsp;Jaime Pignatelli ,&nbsp;Paolo Blasi ,&nbsp;Valle Palomo","doi":"10.1016/j.addr.2025.115561","DOIUrl":"10.1016/j.addr.2025.115561","url":null,"abstract":"<div><div>Circadian rhythms and their involvement with various human diseases, including neurological disorders, have become an intense area of research for the development of new pharmacological treatments. The location of the circadian clock machinery in the central nervous system makes it challenging to reach molecular targets at therapeutic concentrations. In addition, a timely administration of the therapeutic agents is necessary to efficiently modulate the circadian clock. Thus, the use of nanoparticles in circadian clock dysfunctions may accelerate their clinical translation by addressing these two key challenges: enhancing brain penetration and/or enabling their formulation in chronodelivery systems. This review describes the implications of the circadian clock in neurological pathologies, reviews potential molecular targets and their modulators and suggests how the use of nanoparticle-based formulations could improve their clinical success. Finally, the potential integration of nanoparticles into chronopharmaceutical drug delivery systems will be described.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115561"},"PeriodicalIF":15.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting tumor-associated microbiome: A new aspect of modulating tumor microenvironment for cancer therapy","authors":"Wantong Song,&nbsp;Leaf Huang","doi":"10.1016/j.addr.2025.115554","DOIUrl":"10.1016/j.addr.2025.115554","url":null,"abstract":"","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115554"},"PeriodicalIF":15.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printing in musculoskeletal interface engineering: Current progress and future directions","authors":"Tianpeng Xu ,&nbsp;Jingdong Rao ,&nbsp;Yongyi Mo ,&nbsp;Avery Chik-Him Lam ,&nbsp;Yuhe Yang ,&nbsp;Sidney Wing-Fai Wong ,&nbsp;Ka-Hing Wong ,&nbsp;Xin Zhao","doi":"10.1016/j.addr.2025.115552","DOIUrl":"10.1016/j.addr.2025.115552","url":null,"abstract":"<div><div>The musculoskeletal system relies on critical tissue interfaces for its function; however, these interfaces are often compromised by injuries and diseases. Restoration of these interfaces is complex by nature which renders traditional treatments inadequate. An emerging solution is three-dimensional printing, which allows for precise fabrication of biomimetic scaffolds to enhance tissue regeneration. This review summarizes the use of 3D printing in creating scaffolds for musculoskeletal interfaces, mainly focusing on advanced techniques such as multi-material printing, bioprinting, and 4D printing. We emphasize the significance of mimicking natural tissue gradients and the selection of appropriate biomaterials to ensure scaffold success. The review outlines state-of-the-art 3D printing technologies, varying from extrusion, inkjet and laser-assisted bioprinting, which are crucial for producing scaffolds with tailored mechanical and biological properties. Applications in cartilage-bone, intervertebral disc, tendon/ligament-bone, and muscle–tendon junction engineering are discussed, highlighting the potential for improved integration and functionality. Furthermore, we address challenges in material development, printing resolution, and the <em>in vivo</em> performance of scaffolds, as well as the prospects for clinical translation. The review concludes by underscoring the transformative potential of 3D printing to advance orthopedic medicine, offering a roadmap for future research at the intersection of biomaterials, drug delivery, and tissue engineering.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"219 ","pages":"Article 115552"},"PeriodicalIF":15.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}