Advanced drug delivery reviews最新文献_第5页

Gut-brain-immune interactions: exploring probiotics as a drug delivery platform for neurological disease 肠道-脑免疫相互作用：探索益生菌作为神经系统疾病的药物传递平台

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-09 DOI: 10.1016/j.addr.2025.115650

Chinmayi R. Gudi , Michael J. Wannemuehler , Thomas J. Mansell

{"title":"Gut-brain-immune interactions: exploring probiotics as a drug delivery platform for neurological disease","authors":"Chinmayi R. Gudi , Michael J. Wannemuehler , Thomas J. Mansell","doi":"10.1016/j.addr.2025.115650","DOIUrl":"10.1016/j.addr.2025.115650","url":null,"abstract":"<div><div>The gut-brain-immune (GBI) axis, connecting gut microbes, neural tissue, and the cells of the immune system, plays a critical role in human health, particularly in relation to neurological diseases. Research in this field over the last few decades shows that disruptions in the microbiome have been linked to chronic inflammation, which may contribute to neurological conditions, including Parkinson’s disease, Alzheimer’s disease, and other mental health disorders. As we gain a greater understanding of the links between these systems, novel therapeutic strategies are being explored to treat disease by modulation of the GBI axis. One of the most promising approaches is the use of live biotherapeutics, such as engineered probiotics, as next-generation drug delivery systems. These live microorganisms can be designed to deliver specific therapeutic compounds to the gut and brain in order to modulate immune responses and reduce inflammation at the source. Probiotics and live biotherapeutics can offer a targeted approach to treating neurological diseases by influencing both the microbiome and immune system. In this review, we outline the research and mechanisms that have been implicated in GBI interactions and highlight the potential of these innovative therapies in treating neurological disorders, emphasizing their role in improving precision medicine through targeted, microbiome-based interventions.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"224 ","pages":"Article 115650"},"PeriodicalIF":15.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gelatin-integrated carbon nanomaterials in nanomedicine: From biosensing and bioprinting to tissue engineering and other biomedical applications 纳米医学中的明胶集成碳纳米材料：从生物传感和生物打印到组织工程和其他生物医学应用

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-09 DOI: 10.1016/j.addr.2025.115649

Mahdi Saeidirad , Nooshin Naderi , Saminalsadat Sehat , Fateme Sadat Qazi , Iman Zare , Mahsa Imani , Heemin Kang , Mojdeh Mirshafiei , Morvarid Koohkhezri , Zahra Sadat , Amir Kashtiaray , Mohammad Mahdavi , Reza Eivazzadeh-Keihan , Ali Maleki , Jianliang Shen

{"title":"Gelatin-integrated carbon nanomaterials in nanomedicine: From biosensing and bioprinting to tissue engineering and other biomedical applications","authors":"Mahdi Saeidirad , Nooshin Naderi , Saminalsadat Sehat , Fateme Sadat Qazi , Iman Zare , Mahsa Imani , Heemin Kang , Mojdeh Mirshafiei , Morvarid Koohkhezri , Zahra Sadat , Amir Kashtiaray , Mohammad Mahdavi , Reza Eivazzadeh-Keihan , Ali Maleki , Jianliang Shen","doi":"10.1016/j.addr.2025.115649","DOIUrl":"10.1016/j.addr.2025.115649","url":null,"abstract":"<div><div>Carbon nanomaterials (CNMs) in combination with hydrogels (gelatin (Gel)) have shown significant potential in diagnostic and therapeutic applications. This study highlights their significant potential and explores their transformative role in biomedicine. By integrating Gel with CNMs, unique synergistic properties combine mechanical, biocompatibility, and biodegradability properties with the exceptional characteristics of nanomaterials, including high surface area, mechanical strength, and functionalization capabilities. These advanced nanocomposites exhibit remarkable potential across diverse biomedical applications such as cancer therapy, bioprinting applications, tissue engineering and regenerative medicine, wound healing, antimicrobial activity, and bio-packaging. Overall, Gel-integrated CNMs represent a new class of materials with significant promise in advancing biosensing technologies and biomedical performance. Their unique combination of properties opens up new opportunities for the development of next-generation healthcare technologies, improved diagnostics, therapies, and medical devices with enhanced performance and functionality.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"224 ","pages":"Article 115649"},"PeriodicalIF":15.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies 克服胰腺癌治疗耐药：挑战和新兴策略

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-09 DOI: 10.1016/j.addr.2025.115647

Taymin du Toit-Thompson , Lionel Leck , Josef Gillson , Nick Pavlakis , Anthony J. Gill , Jaswinder S. Samra , Anubhav Mittal , Sumit Sahni

引用次数: 0

From cell-SELEX to tissue-SELEX for targeted drug delivery and aptamer nanomedicine 从细胞selex到组织- selex用于靶向药物递送和适体纳米药物

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-04 DOI: 10.1016/j.addr.2025.115646

Ka-Ying Wong , Man-Sau Wong , Jung Heon Lee , Juewen Liu

{"title":"From cell-SELEX to tissue-SELEX for targeted drug delivery and aptamer nanomedicine","authors":"Ka-Ying Wong , Man-Sau Wong , Jung Heon Lee , Juewen Liu","doi":"10.1016/j.addr.2025.115646","DOIUrl":"10.1016/j.addr.2025.115646","url":null,"abstract":"<div><div>Aptamers are nucleic acid-based ligands that can selectively bind to target molecules. Because of their unique target-binding properties, the use of aptamers for targeting cell surface molecules has attracted broad research interest. The field has evolved from selecting aptamers against purified surface proteins to using whole cells (cell-SELEX) as targets. To further advance the field, the concept of tissue-SELEX was later proposed to ensure that selected aptamers possess optimal binding properties in more native <em>in vivo</em> environments. In this article, we review recent progress made for tissue-SELEX, covering methods including tissue slide-based SELEX, morph-X-SELEX, <em>ex vivo</em>-SELEX, and microfluidic tissue-SELEX. The target tissues include cornea, breast, ovary, lung, cardiac and thyroid tissues. For the diseases targeted, cancer is the most extensively studied followed by cardiomyopathies and vascular conditions. The advantages of each method are discussed and potential limitations are also critically reviewed. Applications of tissue- or <em>in vivo</em>-SELEX-derived aptamers in drug delivery include local administration for ocular diseases and systemic administration for lung cancer. Finally, future directions are discussed, emphasizing the need for systematic comparative studies to evaluate cell-SELEX and tissue-SELEX derived aptamers, using antibodies as benchmarks to guide the development of clinically relevant therapeutic applications.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"224 ","pages":"Article 115646"},"PeriodicalIF":15.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergen to asset: Pollen-based drug delivery systems 过敏原对资产：基于花粉的药物输送系统

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-03 DOI: 10.1016/j.addr.2025.115643

Mohammed Shahrudin Ibrahim , Abdul Rahim Ferhan , Chenchen Zhou , Jian Li , Yu-Chien Lin , Jingyu Deng , Ze Zhao , Nam-Joon Cho

{"title":"Allergen to asset: Pollen-based drug delivery systems","authors":"Mohammed Shahrudin Ibrahim , Abdul Rahim Ferhan , Chenchen Zhou , Jian Li , Yu-Chien Lin , Jingyu Deng , Ze Zhao , Nam-Joon Cho","doi":"10.1016/j.addr.2025.115643","DOIUrl":"10.1016/j.addr.2025.115643","url":null,"abstract":"<div><div>The rising demand for therapeutics, driven by aging populations and chronic diseases, challenges the pharmaceutical manufacturing of sustainable drug delivery systems. While development of microcarriers from natural sources such as plant or animal-sourced polymers and lipids show promise, the resource-intensive and complex processes involved limits their translatability and access. In this review, we discuss briefly the existing microcarriers fabricated from natural polymers and transition to recent efforts that have been devoted to exemplify pollen, traditionally regarded as an allergen, exhibits qualities that fit the criteria of a desirable microcarrier, and can be exploited to be valuable drug delivery assets with potential of encapsulating a wide spectrum of cargo and targeted conveyance. We scope through the various derivatives of pollen-derived microcarriers, especially highlighting the recent development of the soft pollen microgel variants, which was designed in alignment with the concept of Cross Economy of transforming abundant, low-value materials to create high-value products through easily portable, innovative and effective processing methods. We further discuss the future outlook of the pollen microgel and suggest aspects of pollen research that needs to be pursued to realize its translation to be a sustainable asset to drug delivery applications.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"224 ","pages":"Article 115643"},"PeriodicalIF":15.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The intersection of circadian rhythms and the blood-brain barrier with drug efficacy and delivery in neurological disorders 昼夜节律和血脑屏障与神经系统疾病药物疗效和递送的交叉

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-07-02 DOI: 10.1016/j.addr.2025.115645

Kyra A. Schindler , Silvia Torices , Nicolette Schurhoff , Daniela Iglesias Gallo , Michal Toborek

{"title":"The intersection of circadian rhythms and the blood-brain barrier with drug efficacy and delivery in neurological disorders","authors":"Kyra A. Schindler , Silvia Torices , Nicolette Schurhoff , Daniela Iglesias Gallo , Michal Toborek","doi":"10.1016/j.addr.2025.115645","DOIUrl":"10.1016/j.addr.2025.115645","url":null,"abstract":"<div><div>Circadian rhythms typically maintain a 24-hour cycle which determines the regulation of many genes and proteins including, but not limited to, those which control the permeability of the blood brain barrier (BBB). The BBB acts as a boundary between circulating blood and the brain, protecting the brain from toxicants, maintaining homeostasis, and regulating perfusion. Importantly, the BBB regulates the efficacy of drug delivery into the central nervous system (CNS). Emerging evidence demonstrates a bi-directional relationship between circadian rhythm dysfunction, neurological disorders, and/or BBB disruption. This means that impaired BBB functions and circadian rhythm dysregulation can be both the driver of neurological disease and the result. As such, both represent an opportunity for therapeutic intervention which can prevent disease development, manage symptoms, or mediate disease progression. This review seeks to describe the changes in both the BBB and circadian rhythms in a series of neurological (stroke, epilepsy, traumatic brain injury), neurodegenerative (Alzheimer’s disease, Parkinson’s disease), and psychiatric disorders (major depressive disorder, schizophrenia). We also describe therapeutic approaches for protecting against both BBB and circadian rhythm dysfunction, methods of surpassing the BBB, and bolstering drug efficacy with chronotherapeutic strategies.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"224 ","pages":"Article 115645"},"PeriodicalIF":15.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic organoids as cancer avatars for true personalized medicine 胰腺类器官作为真正个性化医疗的癌症化身

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-06-27 DOI: 10.1016/j.addr.2025.115642

Johann Gout , Menar Ekizce , Elodie Roger , Alexander Kleger

{"title":"Pancreatic organoids as cancer avatars for true personalized medicine","authors":"Johann Gout , Menar Ekizce , Elodie Roger , Alexander Kleger","doi":"10.1016/j.addr.2025.115642","DOIUrl":"10.1016/j.addr.2025.115642","url":null,"abstract":"<div><div>Pancreatic ductal adenocarcinoma (PDAC) is a lethal solid malignancy, rapidly progressing and highly therapeutic resistant, as reflected by its very low five-year overall survival. Despite significant advancements in our understanding of its pathobiology and the molecular mechanisms driving its tumorigenesis, therapeutic options remain limited and yield only modest clinical responses. PDAC is characterized by a high genetic inter and intratumoral heterogeneity that shapes its mutational landscape and affects its response to therapies. Facing the limitations of existing preclinical models, the development of personalized medicine in PDAC has been hampered. Translational pancreatic cancer research has been accelerated by the emergence of patient-derived organoids (PDOs), <em>in vitro</em> models faithfully preserving genetic, transcriptomic, proteomic, and epigenetic features and heterogeneity of the parental tumors. This review presents how PDO models can revolutionize precision oncology in pancreatic cancer by prognosticating tumor response and thereby, assist clinical decision-making. Their potential as a preclinical platform for biomarker and drug discovery, as well as future directions for enhancing the therapy response predictive power of organoid-based systems are also discussed.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"224 ","pages":"Article 115642"},"PeriodicalIF":15.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon dots in drug delivery and therapeutic applications 碳点在药物传递和治疗中的应用

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-06-26 DOI: 10.1016/j.addr.2025.115644

Hemant Singh , Mahmood Razzaghi , Hamed Ghorbanpoor , Aliakbar Ebrahimi , Huseyin Avci , Mohsen Akbari , Shabir Hassan

{"title":"Carbon dots in drug delivery and therapeutic applications","authors":"Hemant Singh , Mahmood Razzaghi , Hamed Ghorbanpoor , Aliakbar Ebrahimi , Huseyin Avci , Mohsen Akbari , Shabir Hassan","doi":"10.1016/j.addr.2025.115644","DOIUrl":"10.1016/j.addr.2025.115644","url":null,"abstract":"<div><div>Carbon dots (CDs) are recently introduced carbon nanomaterials showing diverse properties. They show unique fluorescent behavior, low production cost, ecofriendliness, electron mobility, potent antioxidant and antibacterial capabilities, good biocompatibility, and abundant functional groups providing opportunities in functionalization for desired properties such as targeted drug delivery, diagnostics, and therapeutics. In this review, we provide a general overview of their synthesis processes, including top-down and bottom-up approaches and their associated benefits and drawbacks. Together with their pros and cons, we also explore the structural and optical properties, photoluminescence mechanisms, free radicals scavenging behavior, toxicity and biological behavior, surface chemistry, and functionalization for drug delivery and therapeutic effects. Furthermore, significant advances in the applicability of CDs such as bioimaging, cellular labelings, cell tracking, biosensing, bioanalytical assays, and therapeutic behavior, like antibacterial properties, tissue engineering, drug delivery system, gene delivery, cancer therapy, photothermal therapy (PTT), photodynamic therapy (PDT), and combinatorial (theranostic) applications are also discussed.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"224 ","pages":"Article 115644"},"PeriodicalIF":15.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing epigenetic inhibitors: A promising approach for overcoming challenges in pancreatic ductal adenocarcinoma treatment 利用表观遗传抑制剂：克服胰腺导管腺癌治疗挑战的有希望的方法。

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-06-16 DOI: 10.1016/j.addr.2025.115638

Immacolata Maietta , África González-Fernández , Rosana Simón-Vázquez

{"title":"Harnessing epigenetic inhibitors: A promising approach for overcoming challenges in pancreatic ductal adenocarcinoma treatment","authors":"Immacolata Maietta , África González-Fernández , Rosana Simón-Vázquez","doi":"10.1016/j.addr.2025.115638","DOIUrl":"10.1016/j.addr.2025.115638","url":null,"abstract":"<div><div>Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and often fatal form of malignancy frequently diagnosed at an advanced stage, posing significant challenges for treatment. The complex and intricate microenvironment of PDAC, characterized by heterogenous tumoral cells harbouring diverse mutations and epigenetic alterations, immune cells (primarily in an immunosuppressive state), cancer-associated fibroblasts (CAFs), low vascularization and extracellular matrix components supporting tumor growth, creates a physical barrier that impedes drug delivery and anti-tumoral immune cell responses, leading to therapy resistance. Despite advancements in early detection methods, and available treatments for PDAC—including surgery, radiotherapy, chemotherapy, and immunotherapy, all have shown limited efficacy. Recently, liposomal drugs in combination therapy, PDAC-targeted CAR-T cells and anti-tumor RNA vaccines have emerged as promising therapeutic approaches. However, significant challenges remain, including the presence of a dense stroma, resistance to chemotherapy, and robust immune suppression, all of which pose substantial barriers to effective treatments.</div><div>In this context, epigenetic therapy aims to modify gene expression patterns in PDAC cells, potentially curtailing their resistance. This review provides an overview of the current landscape of PDAC research and the role of epigenetic inhibitors in the treatment of this lethal disease, emphasizing the potential of combining these novel drugs with conventional chemotherapy or immunotherapy, new drug delivery approaches and future directions in the field. A multi-approach therapy, switch to simultaneously targeting various facets of the PDAC characteristics, could enhance the anti-tumoral efficacy by overcoming its resistance mechanisms, improving patient prognosis.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"224 ","pages":"Article 115638"},"PeriodicalIF":15.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation 脑药物输送的新时代：血脑屏障渗透整合多价和计算优化

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-06-14 DOI: 10.1016/j.addr.2025.115637

Giulia Porro , Marco Basile , Zhengdong Xie , Gian Marco Tuveri , Giuseppe Battaglia , Cátia D.F. Lopes

引用次数: 0