{"title":"Optical coherence tomography for noninvasive monitoring of drug delivery","authors":"Salavat R. Aglyamov, Kirill V. Larin","doi":"10.1016/j.addr.2025.115571","DOIUrl":null,"url":null,"abstract":"<div><div>Optical Coherence Tomography (OCT) has revolutionized various medical imaging and diagnostics fields, offering unprecedented insights into the microstructural compositions of biological tissues. In recent years, OCT applications have been extended to noninvasive drug delivery monitoring, which is a critical aspect of many therapeutic procedures and pharmacokinetic studies. Such an extension is strongly enhanced by the inherent combination with 3D anatomical images provided by OCT. This review presents an overview of the principles of OCT technology, its functional extensions for drug delivery systems, and its advancements in monitoring therapeutic interventions. We discuss its advantages over traditional imaging modalities in terms of spatial resolution, depth penetration, and real-time capabilities. The paper highlights significant studies that have utilized OCT for the visualization and quantification of drug delivery processes, including the diffusion of injectable formulations in ocular tissues and the permeation of topical drugs through the skin. In the review, we focused on the latest OCT applications, including OCT-guided drug injection, topical drug delivery monitoring, application of OCT in inhaled drug delivery systems, and the integration of OCT with other imaging modalities.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"220 ","pages":"Article 115571"},"PeriodicalIF":15.2000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced drug delivery reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0169409X25000560","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Optical Coherence Tomography (OCT) has revolutionized various medical imaging and diagnostics fields, offering unprecedented insights into the microstructural compositions of biological tissues. In recent years, OCT applications have been extended to noninvasive drug delivery monitoring, which is a critical aspect of many therapeutic procedures and pharmacokinetic studies. Such an extension is strongly enhanced by the inherent combination with 3D anatomical images provided by OCT. This review presents an overview of the principles of OCT technology, its functional extensions for drug delivery systems, and its advancements in monitoring therapeutic interventions. We discuss its advantages over traditional imaging modalities in terms of spatial resolution, depth penetration, and real-time capabilities. The paper highlights significant studies that have utilized OCT for the visualization and quantification of drug delivery processes, including the diffusion of injectable formulations in ocular tissues and the permeation of topical drugs through the skin. In the review, we focused on the latest OCT applications, including OCT-guided drug injection, topical drug delivery monitoring, application of OCT in inhaled drug delivery systems, and the integration of OCT with other imaging modalities.
期刊介绍:
The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery.
In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.