Advanced drug delivery reviews最新文献_第4页

Next generation concepts in dermal delivery, theranostics, and preclinical testing 真皮递送、治疗和临床前测试的新一代概念

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115482

Sarah Hedtrich, Marcelo Calderón

引用次数: 0

Recent advances in 3D bioprinted neural models: A systematic review on the applications to drug discovery 生物3D打印神经模型的最新进展：在药物发现中的应用综述

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2025.115524

Amanda Orr , Farnoosh Kalantarnia , Shama Nazir , Behzad Bolandi , Dominic Alderson , Kerrin O’Grady , Mina Hoorfar , Lisa M. Julian , Stephanie M. Willerth

{"title":"Recent advances in 3D bioprinted neural models: A systematic review on the applications to drug discovery","authors":"Amanda Orr , Farnoosh Kalantarnia , Shama Nazir , Behzad Bolandi , Dominic Alderson , Kerrin O’Grady , Mina Hoorfar , Lisa M. Julian , Stephanie M. Willerth","doi":"10.1016/j.addr.2025.115524","DOIUrl":"10.1016/j.addr.2025.115524","url":null,"abstract":"<div><div>The design of neural tissue models with architectural and biochemical relevance to native tissues opens the way for the fundamental study and development of therapies for many disorders with limited treatment options. Here, we systematically review the most recent literature on 3D bioprinted neural models, including their potential for use in drug screening. Neural tissues that model the central nervous system (CNS) from the relevant literature are reviewed with comprehensive summaries of each study, and discussion of the model types, bioinks and additives, cell types used, bioprinted construct shapes and culture time, and the characterization methods used. In this review, we accentuate the lack of standardization among characterization methods to analyze the functionality (including chemical, metabolic and other pathways) and mechanical relevance of the 3D bioprinted constructs, and discuss this as a critical area for future exploration. These gaps must be addressed for this technology to be applied for effective drug screening applications, despite its enormous potential for rapid and efficient drug screening. The future of biomimetic, 3D printed neural tissues is promising and evaluation of the <em>in vivo</em> relevance on multiple levels should be sought to adequately compare model performance and develop viable treatment options for neurodegenerative diseases, or other conditions that affect the CNS.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"218 ","pages":"Article 115524"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visualizing kinetics of diffusional penetration in tissues using OCT-based strain imaging 利用基于oct的应变成像技术可视化组织中扩散渗透的动力学

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115484

Y.M. Alexandrovskaya , A.A. Sovetsky , E.M. Kasianenko , A.L. Matveyev , L.A. Matveev , O.I. Baum , V.Y. Zaitsev

{"title":"Visualizing kinetics of diffusional penetration in tissues using OCT-based strain imaging","authors":"Y.M. Alexandrovskaya , A.A. Sovetsky , E.M. Kasianenko , A.L. Matveyev , L.A. Matveev , O.I. Baum , V.Y. Zaitsev","doi":"10.1016/j.addr.2024.115484","DOIUrl":"10.1016/j.addr.2024.115484","url":null,"abstract":"<div><div>We report a new application of the recently developed technique, Optical Coherence Elastography (OCE) to quantitatively visualize kinetics of osmotic strains due to diffusive penetration of various osmotically active solutions into biological tissues. The magnitude of osmotic strains may range from fractions of one per cent to tens per cent. The visualized spatio-tempotal dynamics of the strains reflect the rates of osmotic dehydration and diffusional penetration of the active solute, which can be controlled by concentration of the solution components. Main features of the OCE-visualized diffusion-front dynamics well agree with Fick’s theory yielding diffusivity coefficients consistent with the literature data. The OCE technique may be used to study diffusion of a broad variety of osmotically-active substances − drugs, cosmetic agents, preservative solutions, so-called optical clearing agents enhancing the depth of optical visualization, etc. The corresponding experimental examples, some results of theoretical interpretations and numerical simulations are given.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115484"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring kinetic processes of drugs and metabolites: Surface-enhanced Raman spectroscopy 监测药物和代谢物的动力学过程：表面增强拉曼光谱

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115483

Zhewen Luo , Haoran Chen , Xinyuan Bi , Jian Ye

{"title":"Monitoring kinetic processes of drugs and metabolites: Surface-enhanced Raman spectroscopy","authors":"Zhewen Luo , Haoran Chen , Xinyuan Bi , Jian Ye","doi":"10.1016/j.addr.2024.115483","DOIUrl":"10.1016/j.addr.2024.115483","url":null,"abstract":"<div><div>Monitoring the kinetic changes of drugs and metabolites plays a crucial role in fundamental research, preclinical and clinical application. Raman spectroscopy (RS) is regarded as a fingerprinting technique that can reflect molecular structures but limited in applications due to poor sensitivity. Surface-enhanced Raman spectroscopy (SERS) significantly amplifies the detection sensitivity by plasmonic substrates, facilitating the identification and quantification of small molecules in biological samples, such as serum, urine, and living cells. This review will focus on advances in how SERS has been utilized to monitor the dynamic processes of small molecule drugs and metabolites in recent years. We first provide readers with a comprehensive overview of the mechanism and practical considerations of SERS, including enhancement theory, substrate design, sample pretreatment, molecule–substrate interactions and spectral analysis. Then we describe the latest advances in SERS for the detection and analysis of metabolites and drugs in cells, dynamic monitoring of drug in various biological matrices, and metabolic profiling for health assessment in biological fluids. We believe that high-performance SERS substrates, standardized technical regulations, and artificial intelligence spectral analysis will boost sensitive, accurate, reproducible, and universal molecular detection in the future. We hoped this review could inspire researchers working in related fields to better understand and utilize SERS for the analytical detection of drugs and metabolites.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115483"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current issues in optical monitoring of drug delivery via hair follicles 毛囊给药光学监测的现状

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115477

Yulia I. Svenskaya , Roman A. Verkhovskii , Sergey M. Zaytsev , Juergen Lademann , Elina A. Genina

{"title":"Current issues in optical monitoring of drug delivery via hair follicles","authors":"Yulia I. Svenskaya , Roman A. Verkhovskii , Sergey M. Zaytsev , Juergen Lademann , Elina A. Genina","doi":"10.1016/j.addr.2024.115477","DOIUrl":"10.1016/j.addr.2024.115477","url":null,"abstract":"<div><div>Drug delivery via hair follicles has attracted much research attention due to its potential to serve for both local and systemic therapeutic purposes. Recent studies on topical application of various particulate formulations have demonstrated a great role of this delivery route for targeting numerous cell populations located in skin and transporting the encapsulated drug molecules to the bloodstream. Despite a great promise of follicle-targeting carriers, their clinical implementation is very rare, mostly because of their poorer characterization compared to conventional topical dosage forms, such as ointments and creams, which have a history spanning over a century. Gathering as complete information as possible on the intrafollicular penetration depth, storage, degradation/metabolization profiles of such carriers and the release kinetics of drugs they contain, as well as their impact on skin health would significantly contribute to understanding the pros and cons of each carrier type and facilitate the selection of the most suitable candidates for clinical trials. Optical imaging and spectroscopic techniques are extensively applied to study dermal penetration of drugs. Current paper provides the state-of-the-art overview of techniques, which are used in optical monitoring of follicular drug delivery, with a special focus on non-invasive <em>in vivo</em> methods. It discusses key features, advantages and limitations of their use, as well as provide expert perspectives on future directions in this field.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115477"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142742743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra-tumoral bacteria in breast cancer and intervention strategies 乳腺癌肿瘤内细菌及其干预策略

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2025.115516

Ting Hou , Xiaoling Huang , Jiahui Lai , Dongfang Zhou

{"title":"Intra-tumoral bacteria in breast cancer and intervention strategies","authors":"Ting Hou , Xiaoling Huang , Jiahui Lai , Dongfang Zhou","doi":"10.1016/j.addr.2025.115516","DOIUrl":"10.1016/j.addr.2025.115516","url":null,"abstract":"<div><div>The microbiome, consisting of a wide range of both beneficial and harmful microorganisms, is vital to various physiological and pathological processes in the human body, including cancer pathogenesis. Tumor progression is often accompanied by the destruction of the vascular system, allowing bacteria to circulate into the tumor area and flourish in an immunosuppressive environment. Microbes are recognized as significant components of the tumor microenvironment. Recent research has increasingly focused on the role of intra-tumoral bacteria in the onset, progression, and treatment of breast cancer—the most prevalent cancer among women. This review elucidates the potential mechanisms by which intra-tumoral bacteria impact breast cancer and discusses different therapeutic approaches aimed at targeting these bacteria. It provides essential insights for enhancing existing treatment paradigms while paving the way for novel anticancer interventions. As our understanding of the microbiome’s intricate relationship with cancer deepens, it opens avenues for groundbreaking strategies that could redefine oncology.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115516"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D extrusion bioprinting of microbial inks for biomedical applications 用于生物医学应用的微生物油墨的3D挤出生物打印

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115505

Nicolas Burns , Arjun Rajesh , Avinash Manjula-Basavanna , Anna Duraj-Thatte

{"title":"3D extrusion bioprinting of microbial inks for biomedical applications","authors":"Nicolas Burns , Arjun Rajesh , Avinash Manjula-Basavanna , Anna Duraj-Thatte","doi":"10.1016/j.addr.2024.115505","DOIUrl":"10.1016/j.addr.2024.115505","url":null,"abstract":"<div><div>In recent years, the field of 3D bioprinting has witnessed the intriguing development of a new type of bioink known as microbial inks. Bioinks, typically associated with mammalian cells, have been reimagined to involve microbes, enabling many new applications beyond tissue engineering and regenerative medicine. This review presents the latest advancements in microbial inks, including their definition, types, composition, salient characteristics, and biomedical applications. Herein, microbes are genetically engineered to produce 1) extrudable bioink and 2) life-like functionalities such as self-regeneration, self-healing, self-regulation, biosynthesis, biosensing, biosignaling, biosequestration, etc. We also discuss some of the promising applications of 3D extrusion printed microbial inks, such as 1) drugs and probiotics delivery, 2) metabolite production, 3) tissue engineering, 4) bioremediation, 5) biosensors and bioelectronics, 6) biominerals and biocomposites, and 7) infectious disease modeling. Finally, we describe some of the current challenges of microbial inks that needs to be addressed in the coming years, to make a greater impact in health science and technology and many other fields.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115505"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Droplet-based 3D bioprinting for drug delivery and screening 用于药物输送和筛选的基于液滴的3D生物打印

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115486

Heqi Xu , Shaokun Zhang , Kaidong Song , Huayong Yang , Jun Yin , Yong Huang

{"title":"Droplet-based 3D bioprinting for drug delivery and screening","authors":"Heqi Xu , Shaokun Zhang , Kaidong Song , Huayong Yang , Jun Yin , Yong Huang","doi":"10.1016/j.addr.2024.115486","DOIUrl":"10.1016/j.addr.2024.115486","url":null,"abstract":"<div><div>Recently, the conventional criterion of “one-size-fits-all” is not qualified for each individual patient, requiring precision medicine for enhanced therapeutic effects. Besides, drug screening is a high-cost and time-consuming process which requires innovative approaches to facilitate drug development rate. Benefiting from consistent technical advances in 3D bioprinting techniques, droplet-based 3D bioprinting techniques have been broadly utilized in pharmaceutics due to the noncontact printing mechanism and precise control on the deposition position of droplets. More specifically, cell-free/cell-laden bioinks which are deposited for the fabrication of drug carriers/3D tissue constructs have been broadly utilized for precise drug delivery and high throughput drug screening, respectively. This review summarizes the mechanism of various droplet-based 3D bioprinting techniques and the most up-to-date applications in drug delivery and screening and discusses the potential improvements of droplet-based 3D bioprinting techniques from both technical and material aspects. Through technical innovations, materials development, and the assistance from artificial intelligence, the formation process of drug carriers will be more stable and accurately controlled guaranteeing precise drug delivery. Meanwhile, the shape fidelity and uniformity of the printed tissue models will be significantly improved ensuring drug screening efficiency and efficacy.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115486"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of pharmacometrics in drug development 药物计量学在药物开发中的应用

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115503

Yuan Xiong , Mahesh N. Samtani , Daniele Ouellet

{"title":"Applications of pharmacometrics in drug development","authors":"Yuan Xiong , Mahesh N. Samtani , Daniele Ouellet","doi":"10.1016/j.addr.2024.115503","DOIUrl":"10.1016/j.addr.2024.115503","url":null,"abstract":"<div><div>The last two decades have witnessed profound changes in how advanced computational tools can help leverage tons of data to improve our knowledge, and ultimately reduce cost and increase productivity in drug development. Pharmacometrics has demonstrated its impact through model-informed drug development (MIDD) approaches. It is now an indispensable component throughout the whole continuum of drug discovery, development, regulatory review, and approval. Today, applications of pharmacometrics are common in designing better trials and accelerating evidence-based decisions. Newly emerging technologies, especially those from data and computer sciences, are being integrated with existing computational tools used in the pharmaceutical industry at a remarkably fast pace. The new challenges faced by the pharmacometrics community are not what or how to contribute, but which optimal MIDD strategy should be adopted to maximize its value in the decision-making process. While we are embracing new innovative approaches and tools, this article discusses how a variety of existing modeling tools, with differentiated advantages and focus, can work in concert to inform drug development.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115503"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing tumor microenvironment and lymphoid tissue research through 3D bioprinting and biofabrication 通过生物3D打印和生物制造推进肿瘤微环境和淋巴组织的研究

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115485

Corrado Mazzaglia , Yan Yan Shery Huang , Jacqueline D. Shields

{"title":"Advancing tumor microenvironment and lymphoid tissue research through 3D bioprinting and biofabrication","authors":"Corrado Mazzaglia , Yan Yan Shery Huang , Jacqueline D. Shields","doi":"10.1016/j.addr.2024.115485","DOIUrl":"10.1016/j.addr.2024.115485","url":null,"abstract":"<div><div>Cancer progression is significantly influenced by the complex interactions within the tumor microenvironment (TME). Immune cells, in particular, play a critical role by infiltrating tumors from the circulation and surrounding lymphoid tissues in an attempt to control their spread. However, they often fail in this task. Current <em>in vivo</em> and <em>in vitro</em> preclinical models struggle to fully capture these intricate interactions affecting our ability to understand immune evasion and predict drugs behaviour in the clinic. To address this challenge, biofabrication and particularly 3D bioprinting has emerged as a promising tool for modeling both tumors and the immune system. Its ability to incorporate multiple cell types into 3D matrices, enable tissue compartmentalization with high spatial accuracy, and integrate vasculature makes it a valuable approach. Nevertheless, limited research has focused on capturing the complex tumor-immune interplay <em>in vitro</em>. This review highlights the composition and significance of the TME, the architecture and function of lymphoid tissues, and innovative approaches to modeling their interactions <em>in vitro</em>, while proposing the concept of an extended TME.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115485"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0