Advanced drug delivery reviews最新文献_第3页

Applications of pharmacometrics in drug development 药物计量学在药物开发中的应用

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115503

Yuan Xiong , Mahesh N. Samtani , Daniele Ouellet

{"title":"Applications of pharmacometrics in drug development","authors":"Yuan Xiong , Mahesh N. Samtani , Daniele Ouellet","doi":"10.1016/j.addr.2024.115503","DOIUrl":"10.1016/j.addr.2024.115503","url":null,"abstract":"<div><div>The last two decades have witnessed profound changes in how advanced computational tools can help leverage tons of data to improve our knowledge, and ultimately reduce cost and increase productivity in drug development. Pharmacometrics has demonstrated its impact through model-informed drug development (MIDD) approaches. It is now an indispensable component throughout the whole continuum of drug discovery, development, regulatory review, and approval. Today, applications of pharmacometrics are common in designing better trials and accelerating evidence-based decisions. Newly emerging technologies, especially those from data and computer sciences, are being integrated with existing computational tools used in the pharmaceutical industry at a remarkably fast pace. The new challenges faced by the pharmacometrics community are not what or how to contribute, but which optimal MIDD strategy should be adopted to maximize its value in the decision-making process. While we are embracing new innovative approaches and tools, this article discusses how a variety of existing modeling tools, with differentiated advantages and focus, can work in concert to inform drug development.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115503"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeing through the skin: Optical methods for visualizing transdermal drug delivery with microneedles 透过皮肤看世界：用光学方法观察微针透皮给药情况

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-02-01 DOI: 10.1016/j.addr.2024.115478

Benchaphorn Limcharoen , Supason Wanichwecharungruang , Wijit Banlunara , Maxim E. Darvin

{"title":"Seeing through the skin: Optical methods for visualizing transdermal drug delivery with microneedles","authors":"Benchaphorn Limcharoen , Supason Wanichwecharungruang , Wijit Banlunara , Maxim E. Darvin","doi":"10.1016/j.addr.2024.115478","DOIUrl":"10.1016/j.addr.2024.115478","url":null,"abstract":"<div><div>Optical methods play a pivotal role in advancing transdermal drug delivery research, particularly with the emergence of microneedle technology. This review presents a comprehensive analysis of optical methods used in studying transdermal drug delivery facilitated by microneedle technology. Beginning with an introduction to microneedle technology and skin anatomy and optical properties, the review explores the integration of optical methods for enhanced visualization. Optical imaging offers key advantages including real-time drug distribution visualization, non-invasive skin response monitoring, and quantitative drug penetration analysis. A spectrum of optical imaging modalities ranging from conventional dermoscopy and stereomicroscopy to advance techniques as fluorescence microscopy, laser scanning microscopy, <em>in vivo</em> imaging system, two-photon microscopy, fluorescence lifetime imaging microscopy, optical coherence tomography, Raman microspectroscopy, laser speckle contrast imaging, and photoacoustic microscopy is discussed. Challenges such as resolution and depth penetration limitations are addressed alongside potential breakthroughs and future directions in optical techniques development. The review underscores the importance of bridging the gap between preclinical and clinical studies, explores opportunities for integrating optical imaging and chemical sensing methods with drug delivery systems, and highlight the importance of non-invasive “optical biopsy” as a valuable alternative to conventional histology. Overall, this review provides insight into the role of optical methods in understanding transdermal drug delivery mechanisms with microneedles.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"217 ","pages":"Article 115478"},"PeriodicalIF":15.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Additive manufacturing in spatial patterning for spinal cord injury treatment

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-27 DOI: 10.1016/j.addr.2025.115523

Christy Kwokdinata , Sing Yian Chew

{"title":"Additive manufacturing in spatial patterning for spinal cord injury treatment","authors":"Christy Kwokdinata , Sing Yian Chew","doi":"10.1016/j.addr.2025.115523","DOIUrl":"10.1016/j.addr.2025.115523","url":null,"abstract":"<div><div>Combinatorial treatments integrating cells and biomolecules within scaffolds have been investigated to address the multifactorial nature of spinal cord injury (SCI). Current regenerative treatments have been ineffective as they do not consider the spatial positions of various cell types to effectively form functional neural pathways. Emulating the complex heterogeneity of cells in the native spinal cord requires translating the existing biological understanding of spatial patterning in neural development, as well as the influence of biomolecule and mechanical patterning on regional specification and axonal regeneration, to engineer a scaffold for spinal cord regeneration. This review explores the potential of 3D bioprinting to precisely control material, cell and drug patterns in scaffolds, achieving spatial phenotype specification and providing axonal guidance to form appropriate connections. We also discuss the application of extrusion-based and digital light processing bioprinting in integrating mechanical, chemical and biological cues within a scaffold to advance spatially patterned 3D bioprinted scaffold, as well as current challenges and future perspectives in these bioengineering strategies.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"218 ","pages":"Article 115523"},"PeriodicalIF":15.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical perspective on pluripotent stem cells derived cell therapies for the treatment of neurodegenerative diseases

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-27 DOI: 10.1016/j.addr.2025.115525

Michal Izrael , Judith Chebath , Kfir Molakandov , Michel Revel

{"title":"Clinical perspective on pluripotent stem cells derived cell therapies for the treatment of neurodegenerative diseases","authors":"Michal Izrael , Judith Chebath , Kfir Molakandov , Michel Revel","doi":"10.1016/j.addr.2025.115525","DOIUrl":"10.1016/j.addr.2025.115525","url":null,"abstract":"<div><div>Self-renewal capacity and potential to differentiate into almost any cell type of the human body makes pluripotent stem cells a valuable starting material for manufacturing of clinical grade cell therapies. Neurodegenerative diseases are characterized by gradual loss of structure or function of neurons, often leading to neuronal death. This results in gradual decline of cognitive, motor, and physiological functions due to the degeneration of the central nervous systems. Over the past two decades, comprehensive preclinical efficacy (proof-of-concept) and safety studies have led to the initiation of First-in-Human phase I-II clinical trials for a range of neurodegenerative diseases. In this review, we explore the fundamentals and challenges of neural-cell therapies derived from pluripotent stem cells for treating neurodegenerative diseases. Additionally, we highlight key preclinical investigations that paved the way for regulatory approvals of these trials. Furthermore, we provide an overview on progress and status of clinical trials done so far in treating neurodegenerative diseases such as spinal cord injury (SCI), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), as well as advances in retina diseases such as Stargardt disease (a.k.a fundus flavimaculatus), retinitis pigmentosa (RP) and age-related macular degeneration (AMD). These trials will pave the way for the development of new cell-based therapies targeting additional neurological conditions, including Alzheimer’s disease and epilepsy.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"218 ","pages":"Article 115525"},"PeriodicalIF":15.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging 突破靶向治疗的障碍：推进外泌体分离、工程和成像

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-22 DOI: 10.1016/j.addr.2025.115522

Anastasiya Kostyusheva , Eugenia Romano , Neng Yan , Manu Lopus , Andrey A. Zamyatnin Jr. , Alessandro Parodi

{"title":"Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging","authors":"Anastasiya Kostyusheva , Eugenia Romano , Neng Yan , Manu Lopus , Andrey A. Zamyatnin Jr. , Alessandro Parodi","doi":"10.1016/j.addr.2025.115522","DOIUrl":"10.1016/j.addr.2025.115522","url":null,"abstract":"<div><div>Exosomes have emerged as promising tools for targeted drug delivery in biomedical applications and medicine. This review delves into the scientific advancements, challenges, and future prospects specifically associated with these technologies. In this work, we trace the research milestones that led to the discovery and characterization of exosomes and extracellular vesicles, and discuss strategies for optimizing the synthetic yield and the loading of these particles with various therapeutics. In addition, we report the current major issues affecting the field and hampering the clinical translation of these technologies. Highlighting the pivotal role of imaging techniques, we explore how they drive exosome therapy and development by offering insights into biodistribution and cellular trafficking dynamics. Methodologies for vesicle isolation, characterization, loading, and delivery mechanisms are thoroughly examined, alongside strategies aimed at enhancing their therapeutic efficacy. Special emphasis was dedicated to their therapeutic properties, particularly to their ability to deliver biologics into the cytoplasm. Furthermore, we delve into the intricate balance between surface modifications and targeting properties including also transgenic methods aimed at their functionalization and visualization within biological systems. This review underscores the transformative potential of these carriers in targeted drug delivery and identifies crucial areas for further research and clinical translation.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"218 ","pages":"Article 115522"},"PeriodicalIF":15.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence lifetime imaging in drug delivery research 荧光寿命成像在给药研究中的应用

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-21 DOI: 10.1016/j.addr.2025.115521

Yiqing Lu , Parinaz Jabbari , Anton Mukhamedshin , Andrei V. Zvyagin

引用次数: 0

Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos 用于监测药物输送的光片荧光显微镜：揭开胚胎发育阶段的神秘面纱

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-20 DOI: 10.1016/j.addr.2025.115520

Gagan Raju , Aymeric Le Gratiet , Giuseppe Sancataldo , Guan-Yu Zhuo , Yury Kistenev , Subir Das , Ajeetkumar Patil , Nirmal Mazumder

{"title":"Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos","authors":"Gagan Raju , Aymeric Le Gratiet , Giuseppe Sancataldo , Guan-Yu Zhuo , Yury Kistenev , Subir Das , Ajeetkumar Patil , Nirmal Mazumder","doi":"10.1016/j.addr.2025.115520","DOIUrl":"10.1016/j.addr.2025.115520","url":null,"abstract":"<div><div>Light sheet fluorescence microscopy (LSFM) has emerged as a transformative imaging technique in the study of drug delivery and embryonic development, offering high-resolution, real-time visualization with minimal phototoxicity. This review examines the application of LSFM in tracking drug pharmacokinetics, tissue-specific targeting, and drug efficacy during critical phases of embryonic development. Recent advancements in fluorescent labeling and machine learning integration have enabled more precise monitoring of drug release, distribution, and interaction with developing tissues. The ability of LSFM to capture long-term dynamics at single-cell resolution has revolutionized drug discovery, especially in nanomedicine and targeted therapies. By integrating LSFM with multimodal imaging and AI-driven data analysis, researchers are now better equipped to explore complex biological processes and optimize drug delivery in a highly controlled, minimally invasive manner. Finally, the review highlights the pivotal role of LSFM in advancing drug delivery research, addressing existing challenges, and unlocking new frontiers in clinical applications.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"218 ","pages":"Article 115520"},"PeriodicalIF":15.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142990853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug delivery systems for treating neurodevelopmental disorders 治疗神经发育障碍的给药系统。

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-01 DOI: 10.1016/j.addr.2024.115473

Boaz Barak, Paolo Decuzzi

引用次数: 0

Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness 社论：纳米材料的亚细胞器靶向技术提高治疗效果

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2025-01-01 DOI: 10.1016/j.addr.2024.115460

Yu Seok Youn, Koen Raemdonck

引用次数: 0

Editorial: Super-resolution imaging of sub-cellular dynamics of drug molecules 药物分子亚细胞动态超分辨率成像。