Advanced drug delivery reviews最新文献_第3页

Biopharmaceutical drug delivery and phototherapy using protein crystals 利用蛋白质晶体进行生物制药给药和光疗

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-11-28 DOI: 10.1016/j.addr.2024.115480

Renbin Zhou , Jinghan Qu , Xuejiao Liu , Fangrui Lin , Tymish Y. Ohulchanskyy , Nuernisha Alifu , Junle Qu , Da-Chuan Yin

{"title":"Biopharmaceutical drug delivery and phototherapy using protein crystals","authors":"Renbin Zhou , Jinghan Qu , Xuejiao Liu , Fangrui Lin , Tymish Y. Ohulchanskyy , Nuernisha Alifu , Junle Qu , Da-Chuan Yin","doi":"10.1016/j.addr.2024.115480","DOIUrl":"10.1016/j.addr.2024.115480","url":null,"abstract":"<div><div>Biopharmaceutical drugs, including proteins, peptides, and antibodies, are renowned for their high specificity and efficacy, fundamentally transforming disease treatment paradigms. However, their structural complexity presents challenges for their formulation and delivery. Protein crystals, characterized by high purity, high stability and a porous structure for biopharmaceutical drug encapsulation, providing a potential avenue for formulating and delivering biopharmaceutical drugs. There is increasing interest in engineering protein crystals to delivery biopharmaceutical drugs for biomedical applications. This review summarizes the recent advances in biopharmaceutical drug delivery and phototherapy using protein crystals. First, we evaluate the advantages of using protein crystals for biopharmaceutical drugs delivery. Next, we outline the strategies for <em>in vitro</em> and <em>in vivo</em> crystallization to prepare protein crystals. Importantly, the review highlights the advanced applications of protein crystals in biopharmaceutical drug delivery, tumor phototherapy, and other optical fields. Finally, it provides insights into future perspectives of biopharmaceutical drug delivery using protein crystals. This comprehensive review aims to provide effective insights into design of protein crystals to simplify biopharmaceutical drug delivery and improve disease treatment.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"216 ","pages":"Article 115480"},"PeriodicalIF":15.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeing through the skin: Optical methods for visualizing transdermal drug delivery with microneedles 透过皮肤看世界：用光学方法观察微针透皮给药情况

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-11-26 DOI: 10.1016/j.addr.2024.115478

Benchaphorn Limcharoen, Supason Wanichwecharungruang, Wijit Banlunara, Maxim E. Darvin

{"title":"Seeing through the skin: Optical methods for visualizing transdermal drug delivery with microneedles","authors":"Benchaphorn Limcharoen, Supason Wanichwecharungruang, Wijit Banlunara, Maxim E. Darvin","doi":"10.1016/j.addr.2024.115478","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115478","url":null,"abstract":"Optical methods play a pivotal role in advancing transdermal drug delivery research, particularly with the emergence of microneedle technology. This review presents a comprehensive analysis of optical methods used in studying transdermal drug delivery facilitated by microneedle technology. Beginning with an introduction to microneedle technology and skin anatomy and optical properties, the review explores the integration of optical methods for enhanced visualization. Optical imaging offers key advantages including real-time drug distribution visualization, non-invasive skin response monitoring, and quantitative drug penetration analysis. A spectrum of optical imaging modalities ranging from conventional dermoscopy and stereomicroscopy to advance techniques as fluorescence microscopy, laser scanning microscopy, <em>in vivo</em> imaging system, two-photon microscopy, fluorescence lifetime imaging microscopy, optical coherence tomography, Raman microspectroscopy, laser speckle contrast imaging, and photoacoustic microscopy is discussed. Challenges such as resolution and depth penetration limitations are addressed alongside potential breakthroughs and future directions in optical techniques development. The review underscores the importance of bridging the gap between preclinical and clinical studies, explores opportunities for integrating optical imaging and chemical sensing methods with drug delivery systems, and highlight the importance of non-invasive “optical biopsy” as a valuable alternative to conventional histology. Overall, this review provides insight into the role of optical methods in understanding transdermal drug delivery mechanisms with microneedles.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"50 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printing of drug delivery systems enhanced with micro/nano-technology 利用微/纳米技术增强给药系统的 3D 打印技术

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-11-26 DOI: 10.1016/j.addr.2024.115479

Hui Zhu , Huijuan Kuang , Xinxin Huang , Xiao Li , Ruosen Zhao , Guojin Shang , Ziyu Wang , Yucheng Liao , Jiankang He , Dichen Li

{"title":"3D printing of drug delivery systems enhanced with micro/nano-technology","authors":"Hui Zhu , Huijuan Kuang , Xinxin Huang , Xiao Li , Ruosen Zhao , Guojin Shang , Ziyu Wang , Yucheng Liao , Jiankang He , Dichen Li","doi":"10.1016/j.addr.2024.115479","DOIUrl":"10.1016/j.addr.2024.115479","url":null,"abstract":"<div><div>Drug delivery systems (DDSs) are increasingly important in ensuring drug safety and enhancing therapeutic efficacy. Micro/nano-technology has been utilized to develop DDSs for achieving high stability, bioavailability, and drug efficiency, as well as targeted delivery; meanwhile, 3D printing technology has made it possible to tailor DDSs with diverse components and intricate structures. This review presents the latest research progress integrating 3D printing technology and micro/nano-technology for developing novel DDSs. The technological fundamentals of 3D printing technology supporting the development of DDSs are presented, mainly from the perspective of different 3D printing mechanisms. Distinct types of DDSs leveraging 3D printing and micro/nano-technology are analyzed deeply, featuring micro/nanoscale materials and structures to enrich functionalities and improve effectiveness. Finally, we will discuss the future directions of 3D-printed DDSs integrated with micro/nano-technology, focusing on technological innovation and clinical application. This review will support interdisciplinary research efforts to advance drug delivery technology.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"216 ","pages":"Article 115479"},"PeriodicalIF":15.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated pharmacokinetic-pharmacodynamic and agent-based modelling in drug development: Current status and future perspectives 药物开发中的药代动力学-药效学和基于代理的综合建模：现状与未来展望

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-11-23 DOI: 10.1016/j.addr.2024.115474

James W.T. Yates

引用次数: 0

Integrated modeling of biomarkers, survival and safety in clinical oncology drug development 临床肿瘤药物开发中的生物标记物、生存和安全性综合建模

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-11-20 DOI: 10.1016/j.addr.2024.115476

Han Liu , Eman I.K. Ibrahim , Maddalena Centanni , Céline Sarr , Karthik Venkatakrishnan , Lena E. Friberg

{"title":"Integrated modeling of biomarkers, survival and safety in clinical oncology drug development","authors":"Han Liu , Eman I.K. Ibrahim , Maddalena Centanni , Céline Sarr , Karthik Venkatakrishnan , Lena E. Friberg","doi":"10.1016/j.addr.2024.115476","DOIUrl":"10.1016/j.addr.2024.115476","url":null,"abstract":"<div><div>Model-based approaches, including population pharmacokinetic-pharmacodynamic modeling, have become an essential component in the clinical phases of oncology drug development. Over the past two decades, models have evolved to describe the temporal dynamics of biomarkers and tumor size, treatment-related adverse events, and their links to survival. Integrated models, defined here as models that incorporate at least two pharmacodynamic/ outcome variables, are applied to answer drug development questions through simulations, e.g., to support the exploration of alternative dosing strategies and study designs in subgroups of patients or other tumor indications. It is expected that these pharmacometric approaches will be expanded as regulatory authorities place further emphasis on early and individualized dosage optimization and inclusive patient-focused development strategies. This review provides an overview of integrated models in the literature, examples of the considerations that need to be made when applying these advanced pharmacometric approaches, and an outlook on the expected further expansion of model-informed drug development of anticancer drugs.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"216 ","pages":"Article 115476"},"PeriodicalIF":15.2,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chaotic (bio)printing in the context of drug delivery systems 药物输送系统中的混沌（生物）印刷

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-11-17 DOI: 10.1016/j.addr.2024.115475

Mario Moisés Alvarez , Ariel Cantoral-Sánchez , Grissel Trujillo-de Santiago

{"title":"Chaotic (bio)printing in the context of drug delivery systems","authors":"Mario Moisés Alvarez , Ariel Cantoral-Sánchez , Grissel Trujillo-de Santiago","doi":"10.1016/j.addr.2024.115475","DOIUrl":"10.1016/j.addr.2024.115475","url":null,"abstract":"<div><div>Chaotic (bio)printing, an innovative fabrication technique that uses chaotic flows to create highly ordered microstructures within materials, may be transformative for drug delivery systems. This review explores the principles underlying chaotic flows and their application in fabricating complex, multi-material constructs designed for advanced drug delivery and controlled release. Chaotic printing enables the precise layering of different active ingredients—a feature that may greatly facilitate the development of polypills with customizable release profiles. Recently, chaos-assisted fabrication has been extended to produce micro-architected hydrogel spheres in a high-throughput manner, potentially enhancing the versatility and efficiency of drug delivery methods. In addition, chaotic bioprinting enables the creation of evolved tissue models that more accurately emulate physiological systems, providing a more relevant platform for drug testing. This review also highlights the unique advantages of chaotic printing, including the ability to fabricate tissues with organized porosity and pre-vascularized structures, addressing critical challenges in tissue engineering. Despite its promising capabilities, challenges remain, particularly in expanding the range of materials compatible with chaotic printing. Continued research and development in this area are essential to fully realize the potential of chaotic (bio)printing in advancing drug delivery, paving the way for the next generation of smart drug delivery systems and functional tissue models for drug testing.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"216 ","pages":"Article 115475"},"PeriodicalIF":15.2,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic overview of strategies for photosensitizer and light delivery in antibacterial photodynamic therapy for lung infections 肺部感染抗菌光动力疗法中光敏剂和光传输策略的系统性概述

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-11-15 DOI: 10.1016/j.addr.2024.115472

Margarita O. Shleeva, Galina R. Demina, Alexander P. Savitsky

{"title":"A systematic overview of strategies for photosensitizer and light delivery in antibacterial photodynamic therapy for lung infections","authors":"Margarita O. Shleeva, Galina R. Demina, Alexander P. Savitsky","doi":"10.1016/j.addr.2024.115472","DOIUrl":"10.1016/j.addr.2024.115472","url":null,"abstract":"<div><div>Antimicrobial photodynamic therapy (aPDT) emerges as a viable treatment strategy for infections resistant to conventional antibiotics. A complex interplay of factors, including intracellular photosensitizer (PS) accumulation, photochemical reaction type, and oxygen levels, determines the efficacy of aPDT. Recent progress includes the development of modified PSs with enhanced lipophilicity and target-specific strategies to improve bacterial cell wall penetration and targeting. Nanotechnology-based approaches, such as using nanomaterials for targeted PS delivery, have shown promise in enhancing aPDT efficacy. Advancements in light delivery methods for aPDT, such as transillumination of large lesions and local light delivery using fiber optic techniques, are also being explored to optimize treatment efficacy in clinical settings. The limited number of animal models and clinical trials specifically designed to assess the efficacy of aPDT for lung infections highlights the need for further research in this critical area. The potential prospects of aPDT for lung tissue infections originating from antibiotic-resistant bacterial infections are also discussed in this review.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"215 ","pages":"Article 115472"},"PeriodicalIF":15.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo 浸泡式光学清除剂在组织中的输送和动力学：从体内到体外的光学成像

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-10-29 DOI: 10.1016/j.addr.2024.115470

Tingting Yu , Xiang Zhong , Dongyu Li , Jingtan Zhu , Valery V. Tuchin , Dan Zhu

{"title":"Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo","authors":"Tingting Yu , Xiang Zhong , Dongyu Li , Jingtan Zhu , Valery V. Tuchin , Dan Zhu","doi":"10.1016/j.addr.2024.115470","DOIUrl":"10.1016/j.addr.2024.115470","url":null,"abstract":"<div><div>Advanced optical imaging provides a powerful tool for the structural and functional analysis of tissues with high resolution and contrast, but the imaging performance decreases as light propagates deeper into the tissue. Tissue optical clearing technique demonstrates an innovative way to realize deep-tissue imaging and have emerged substantially in the last two decades. Here, we briefly reviewed the basic principles of tissue optical clearing techniques in the view of delivery strategies via either free diffusion or external forces-driven advection, and the commonly-used optical techniques for monitoring kinetics of clearing agents in tissue, as well as their <em>ex vivo</em> to <em>in vivo</em> applications in multiple biomedical research fields. With future efforts on the even distribution of both clearing agents and probes, excavation of more effective clearing agents, and automation of tissue clearing processes, tissue optical clearing should provide more insights into the fundamental questions in biological events clinical diagnostics.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"215 ","pages":"Article 115470"},"PeriodicalIF":15.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids 细胞外囊泡与脂质纳米颗粒在递送核酸方面的比较

IF 15.2 1区医学

Advanced drug delivery reviews Pub Date : 2024-10-28 DOI: 10.1016/j.addr.2024.115461

Johannes Bader, Finn Brigger, Jean-Christophe Leroux

{"title":"Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids","authors":"Johannes Bader, Finn Brigger, Jean-Christophe Leroux","doi":"10.1016/j.addr.2024.115461","DOIUrl":"10.1016/j.addr.2024.115461","url":null,"abstract":"<div><div>Extracellular vesicles (EVs) are increasingly investigated for delivering nucleic acid (NA) therapeutics, leveraging their natural role in transporting NA and protein-based cargo in cell-to-cell signaling. Their synthetic counterparts, lipid nanoparticles (LNPs), have been developed over the past decades as NA carriers, culminating in the approval of several marketed formulations such as patisiran/Onpattro® and the mRNA-1273/BNT162 COVID-19 vaccines. The success of LNPs has sparked efforts to develop innovative technologies to target extrahepatic organs, and to deliver novel therapeutic modalities, such as tools for <em>in vivo</em> gene editing. Fueled by the recent advancements in both fields, this review aims to provide a comprehensive overview of the basic characteristics of EV and LNP-based NA delivery systems, from EV biogenesis to structural properties of LNPs. It addresses the primary challenges encountered in utilizing these nanocarriers from a drug formulation and delivery perspective. Additionally, biodistribution profiles, <em>in vitro</em> and <em>in vivo</em> transfection outcomes, as well as their status in clinical trials are compared. Overall, this review provides insights into promising research avenues and potential dead ends for EV and LNP-based NA delivery systems.</div></div>","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"215 ","pages":"Article 115461"},"PeriodicalIF":15.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Editorial: Advanced strategies to bridge the gap between inflammation and tissue regeneration” [Adv. Drug Deliv. Rev. 209 (2024) 115328] 社论：弥合炎症和组织再生之间差距的先进战略"[Adv. Drug Deliv. Rev. 209 (2024) 115328]

IF 16.1 1区医学

Advanced drug delivery reviews Pub Date : 2024-10-22 DOI: 10.1016/j.addr.2024.115457

Márcia T. Rodrigues, Manuela E. Gomes

引用次数: 0