3D printing of pharmaceutical dosage forms: Recent advances and applications

IF 15.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2024-12-19 DOI:10.1016/j.addr.2024.115504

Auel Tobias, Mentrup Aaron Felix Christofer, Oldfield Lee Roy, Seidlitz Anne

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Abstract

Three-dimensional (3D) printing, also referred to as additive manufacturing, is considered to be a game-changing technology in many industries and is also considered to have potential use cases in pharmaceutical manufacturing, especially if individualization is desired. In this review article the authors systematically researched literature published during the last 5 years (2019 – spring 2024) on the topic of 3D printed dosage forms. Besides all kinds of oral dosage forms ranging from tablets and capsules to films, pellets, etc., numerous reports were also identified on parenteral and cutaneous dosage forms and also rectal, vaginal, dental, intravesical, and ophthalmic preparations. In total, more than 500 publications were identified and grouped according to the site of administration, and an overview of the manuscripts is presented here. Furthermore, selected publications are described and discussed in more detail. The review highlights the very different approaches that are currently used in order to develop 3D printed dosage forms but also addresses remaining challenges.

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三维（3D）打印，也称为增材制造，被认为是改变许多行业游戏规则的技术，也被认为在医药制造中具有潜在的用例，尤其是在需要个性化的情况下。在这篇综述文章中，作者系统地研究了过去 5 年（2019 年至 2024 年春）内发表的有关 3D 打印剂型主题的文献。除了从片剂、胶囊到薄膜、颗粒等各种口服剂型外，还发现了大量关于肠外和皮肤剂型以及直肠、阴道、牙科、膀胱内和眼科制剂的报道。总共确定了 500 多篇出版物，并根据给药部位进行了分组，在此对这些手稿进行了概述。此外，还对部分出版物进行了详细描述和讨论。综述重点介绍了目前用于开发 3D 打印剂型的各种不同方法，同时也探讨了仍然存在的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.