BME frontiers最新文献_第3页

Intracellular Protein Delivery: Approaches, Challenges, and Clinical applications 细胞内蛋白质传递：方法、挑战和临床应用

BME frontiers Pub Date : 2023-12-18 DOI: 10.34133/bmef.0035

Alexander Chan, Andrew Tsourkas

引用次数: 0

Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices 毫米级动物的可扩展电生理与电极装置

BME frontiers Pub Date : 2023-11-13 DOI: 10.34133/bmef.0034

Kairu Dong, Wen-Che Liu, Yuyan Su, Yidan Lyu, Hao Huang, Nenggan Zheng, John A Rogers, Kewang Nan

引用次数: 0

Perspective: Limiting Antimicrobial Resistance with Artificial Intelligence/Machine Learning 视角:利用人工智能/机器学习限制抗菌素耐药性

BME frontiers Pub Date : 2023-11-03 DOI: 10.34133/bmef.0033

Daniel Amsterdam

引用次数: 0

Transcranial Acoustic Metamaterial Parameters Inverse Designed by Neural Networks. 神经网络设计的经颅声学超材料参数反演。

BME frontiers Pub Date : 2023-09-25 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0030

Yuming Yang, Dong Jiang, Qiongwen Zhang, Xiaoxia Le, Tao Chen, Huilong Duan, Yinfei Zheng

{"title":"Transcranial Acoustic Metamaterial Parameters Inverse Designed by Neural Networks.","authors":"Yuming Yang, Dong Jiang, Qiongwen Zhang, Xiaoxia Le, Tao Chen, Huilong Duan, Yinfei Zheng","doi":"10.34133/bmef.0030","DOIUrl":"10.34133/bmef.0030","url":null,"abstract":"Objective: The objective of this work is to investigate the mapping relationship between transcranial ultrasound image quality and transcranial acoustic metamaterial parameters using inverse design methods. Impact Statement: Our study provides insights into inverse design methods and opens the route to guide the preparation of transcranial acoustic metamaterials. Introduction: The development of acoustic metamaterials has enabled the exploration of cranial ultrasound, and it has been found that the influence of the skull distortion layer on acoustic waves can be effectively eliminated by adjusting the parameters of the acoustic metamaterial. However, the interaction mechanism between transcranial ultrasound images and transcranial acoustic metamaterial parameters is unknown. Methods: In this study, 1,456 transcranial ultrasound image datasets were used to explore the mapping relationship between the quality of transcranial ultrasound images and the parameters of transcranial acoustic metamaterials. Results: The multioutput parameter prediction model of transcranial metamaterials based on deep back-propagation neural network was built, and metamaterial parameters under transcranial image evaluation indices are predicted using the prediction model. Conclusion: This inverse big data design approach paves the way for guiding the preparation of transcranial metamaterials.","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Erratum to "BME 2.0: Engineering the Future of Medicine". “BME 2.0：医学未来工程”勘误表。

IF 5

BME frontiers Pub Date : 2023-09-20 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0028

Michael I Miller, Andrew O Brightman, Frederick H Epstein, K Jane Grande-Allen, Jordan J Green, Eileen Haase, Cato T Laurencin, Elizabeth Logsdon, Feilim Mac Gabhann, Brenda Ogle, Chun Wang, George R Wodicka, Raimond L Winslow

引用次数: 0

Erratum to "Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease". “人类炎症性肺病远端肺酶活性的光学检测”勘误表。

IF 5

BME frontiers Pub Date : 2023-09-20 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0029

Alicia Megia-Fernandez, Adam Marshall, Ahsan R Akram, Bethany Mills, Sunay V Chankeshwara, Emma Scholefield, Amy Miele, Bruce C McGorum, Chesney Michaels, Nathan Knighton, Tom Vercauteren, Francois Lacombe, Veronique Dentan, Annya M Bruce, Joanne Mair, Robert Hitchcock, Nik Hirani, Chris Haslett, Mark Bradley, Kevin Dhaliwal

引用次数: 0

Efficient Simultaneous Detection of Metabolites Based on Electroenzymatic Assembly Strategy. 基于电酶组装策略的代谢产物高效同时检测。

BME frontiers Pub Date : 2023-09-19 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0027

Anran Zheng, Chao Li, Shengkai Xu, Zhen Guo, Chuanyu Li, Changsong Zhang, Jia Yao, Zhiqi Zhang, Jinze Li, Lutao Du, Shasha Zhao, Chuanxin Wang, Wei Zhang, Lianqun Zhou

{"title":"Efficient Simultaneous Detection of Metabolites Based on Electroenzymatic Assembly Strategy.","authors":"Anran Zheng, Chao Li, Shengkai Xu, Zhen Guo, Chuanyu Li, Changsong Zhang, Jia Yao, Zhiqi Zhang, Jinze Li, Lutao Du, Shasha Zhao, Chuanxin Wang, Wei Zhang, Lianqun Zhou","doi":"10.34133/bmef.0027","DOIUrl":"https://doi.org/10.34133/bmef.0027","url":null,"abstract":"Objective and Impact Statement: We describe an electroenzymatic mediator (EM) sensor based on an electroenzymatic assembly peak separation strategy, which can efficiently realize the simultaneous detection of 3 typical cardiovascular disease (CVD) metabolites in 5 μl of plasma under one test. This work has substantial implications toward improving the efficiency of chronic CVD assessment. Introduction: Monitoring CVD of metabolites is strongly associated with disease risk. Independent and time-consuming detection in hospitals is unfavorable for chronic CVD management. Methods: The EM was flexibly designed by the cross-linking of electron mediators and enzymes, and 3 EM layers with different characteristics were assembled on one electrode. Electrons were transferred under tunable potential; 3 metabolites were quantitatively detected by 3 peak currents that correlated with metabolite concentrations. Results: In this study, the EM sensor showed high sensitivity for the simultaneous detection of 3 metabolites with a lower limit of 0.01 mM. The linear correlation between the sensor and clinical was greater than 0.980 for 242 patients, and the consistency of risk assessment was 94.6%. Conclusion: Metabolites could be expanded by the EM, and the sensor could be a promising candidate as a home healthcare tool for CVD risk assessment.","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Poly(Ester Amide) Structure on Properties and Drug Delivery for Prostate Cancer Therapy. 聚（酯酰胺）结构对前列腺癌症治疗的性质和药物递送的影响。

IF 5

BME frontiers Pub Date : 2023-08-10 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0025

Junfu Zhang, Liying Wang, Mengting Ding, Xinru You, Jun Wu, Jun Pang

{"title":"Impact of Poly(Ester Amide) Structure on Properties and Drug Delivery for Prostate Cancer Therapy.","authors":"Junfu Zhang, Liying Wang, Mengting Ding, Xinru You, Jun Wu, Jun Pang","doi":"10.34133/bmef.0025","DOIUrl":"10.34133/bmef.0025","url":null,"abstract":"Objective: We aim to develop a polymer library consisting of phenylalanine-based poly(ester amide)s (Phe-PEAs) for cancer therapy and investigate the structure-property relationship of these polymers to understand their impact on the drug delivery efficiency of corresponding nanoparticles (NPs). Impact Statement: Our study provides insights into the structure-property relationship of polymers in NP-based drug delivery applications and offers a potential polymer library and NP platform for enhancing cancer therapy. Introduction: Polymer NP-based drug delivery systems have demonstrated substantial potential in cancer therapy by improving drug efficacy and minimizing systemic toxicity. However, successful design and optimization of these systems require a comprehensive understanding of the relationship between polymer structure and physicochemical properties, which directly influence the drug delivery efficiency of the corresponding NPs. Methods: A series of Phe-PEAs with tunable structures was synthesized by varying the length of the methylene group in the diol part of the polymers. Subsequently, Phe-PEAs were formulated into NPs for doxorubicin (DOX) delivery in prostate cancer therapy. Results: Small adjustments in polymer structure induced the changes in the hydrophobicity and thermal properties of the PEAs, consequently NP size, drug loading capacity, cellular uptake efficacy, and cytotoxicity. Additionally, DOX-loaded Phe-PEA NPs demonstrated enhanced tumor suppression and reduced side effects in prostate tumor-bearing mice. Conclusion: Phe-PEAs, with their finely tunable structures, show great promise as effective and customizable nanocarriers for cancer therapy.","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encapsulation of Ru(II) Polypyridine Complexes for Tumor-Targeted Anticancer Therapy. Ru（II）多吡啶配合物的包封用于肿瘤靶向抗癌治疗。

BME frontiers Pub Date : 2023-08-01 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0024

Johannes Karges

引用次数: 1

Antibacterial Chemodynamic Therapy: Materials and Strategies. 抗菌化学动力学治疗：材料与策略。

BME frontiers Pub Date : 2023-07-17 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0021

Chenyang Jia, Fu-Gen Wu

{"title":"Antibacterial Chemodynamic Therapy: Materials and Strategies.","authors":"Chenyang Jia, Fu-Gen Wu","doi":"10.34133/bmef.0021","DOIUrl":"https://doi.org/10.34133/bmef.0021","url":null,"abstract":"The wide and frequent use of antibiotics in the treatment of bacterial infection can cause the occurrence of multidrug-resistant bacteria, which becomes a serious health threat. Therefore, it is necessary to develop antibiotic-independent treatment modalities. Chemodynamic therapy (CDT) is defined as the approach employing Fenton and/or Fenton-like reactions for generating hydroxyl radical (•OH) that can kill target cells. Recently, CDT has been successfully employed for antibacterial applications. Apart from the common Fe-mediated CDT strategy, antibacterial CDT strategies mediated by other metal elements such as copper, manganese, cobalt, molybdenum, platinum, tungsten, nickel, silver, ruthenium, and zinc have also been proposed. Furthermore, different types of materials like nanomaterials and hydrogels can be adopted for constructing CDT-involved antibacterial platforms. Besides, CDT can introduce some toxic metal elements and then achieve synergistic antibacterial effects together with reactive oxygen species. Finally, CDT can be combined with other therapies such as starvation therapy, phototherapy, and sonodynamic therapy for achieving improved antibacterial performance. This review first summarizes the advancements in antibacterial CDT and then discusses the present limitations and future research directions in this field, hoping to promote the development of more effective materials and strategies for achieving potentiated CDT.","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2