BME frontiers最新文献

{"title":"NucleoCraft: The Art of Stimuli-Responsive Precision in DNA and RNA Bioengineering","authors":"Hao Yan, Lu Yu, Liangxiao Chen, Deeksha Satyabola, Abhay Prasad","doi":"10.34133/bmef.0050","DOIUrl":"https://doi.org/10.34133/bmef.0050","url":null,"abstract":"","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141686008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering Bacteria and Their Derivatives for Cancer Immunotherapy","authors":"Yuji Tang, Lang Rao","doi":"10.34133/bmef.0047","DOIUrl":"https://doi.org/10.34133/bmef.0047","url":null,"abstract":"","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141379860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baroreceptor-inspired microneedle skin patch for pressure-controlled drug release","authors":"Jiahui He, M. Zheng, Tianli Hu, Ya Huang, Jingyou Su, Chunyi Zhi, Xinge Yu, Chenjie Xu","doi":"10.34133/bmef.0044","DOIUrl":"https://doi.org/10.34133/bmef.0044","url":null,"abstract":"","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140685584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Nanomaterials in Endodontics","authors":"Farzaneh Afkhami, Yuan Chen, Laurence J. Walsh, O. Peters, Chun Xu","doi":"10.34133/bmef.0043","DOIUrl":"https://doi.org/10.34133/bmef.0043","url":null,"abstract":"","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140377827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controllable Thrombolysis Using a Nanobubble-Imaging-Guided rtPA Targeted Delivery Strategy.","authors":"Jian Tang, Huiting Xu, Mingxi Li, Yang Liu, Fang Yang","doi":"10.34133/bmef.0040","DOIUrl":"10.34133/bmef.0040","url":null,"abstract":"<p><p><b>Objective:</b> The objective of this work is to design and fabricate a novel multifunctional nanocarrier combining thrombus-targeted imaging and ultrasound-mediated drug delivery for the theranostics of thrombotic diseases. <b>Impact Statement:</b> This study develops a new technology that can accurately visualize the thrombus and deliver drugs with controllable properties to diagnose and treat thrombotic diseases. <b>Introduction:</b> Thrombotic diseases are a serious threat to human life and health. The diagnosis and treatment of thrombotic diseases have always been a challenge. In recent years, nanomedicine has brought new ideas and new methods for the theranostics of thrombotic diseases. However, there are also many problems need to be solved, such as biosafety and stability of nanocarriers, early diagnosis, and timely treatment of thrombotic diseases, difficulty in clinical translation. <b>Methods:</b> The S1P@CD-PLGA-rtPA nanobubbles (NBs) were prepared by integrating sulfur hexafluoride (SF₆)-loaded poly (D, L-lactide-co-glycolide) (PLGA) NBs, cyclodextrin (CD), sphingosine-1-phosphate (S1P), and recombinant tissue plasminogen activator (rtPA). <b>Results:</b> S1P@CD-PLGA-rtPA NBs had rapid and excellent thrombosis targeting imaging performance based on the specific interaction of S1P-S1PR1 (sphingosine-1-phosphate receptor 1). Furthermore, S1P@CD-PLGA-rtPA NBs that specifically targeting to the thrombosis regions could also respond to external ultrasound to achieve accurate and efficient delivery of rtPA to enhance the thrombolysis effectiveness and efficiency. <b>Conclusion:</b> This study proposes a new idea and strategy of targeting thrombus in rats via the specific interaction of S1P-S1PR1. On this basis, the acoustic response properties of bubble carriers could be fully utilized by combining thrombus-specific targeted imaging and ultrasound-mediated drug delivery for effective thrombolysis, which is expected to be applied in targeted diagnosis and treatment of thrombotic diseases in the future.</p>","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Evaluation of Synthetic Delivery Formulations for Peptide-Based Cancer Vaccines.","authors":"Kefan Song, Suzie H Pun","doi":"10.34133/bmef.0038","DOIUrl":"10.34133/bmef.0038","url":null,"abstract":"<p><p>With the recent advances in neoantigen identification, peptide-based cancer vaccines offer substantial potential in the field of immunotherapy. However, rapid clearance, low immunogenicity, and insufficient antigen-presenting cell (APC) uptake limit the efficacy of peptide-based cancer vaccines. This review explores the barriers hindering vaccine efficiency, highlights recent advancements in synthetic delivery systems, and features strategies for the key delivery steps of lymph node (LN) drainage, APC delivery, cross-presentation strategies, and adjuvant incorporation. This paper also discusses the design of preclinical studies evaluating vaccine efficiency, including vaccine administration routes and murine tumor models.</p>","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10956738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Ablative Gastrointestinal Imaging Capsule for Esophagus Surveillance & Interventions","authors":"Hyeon-Cheol Park, Dawei Li, Rongguang Liang, Gina Adrales, Xingde Li","doi":"10.34133/bmef.0041","DOIUrl":"https://doi.org/10.34133/bmef.0041","url":null,"abstract":"","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140257487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-Time Reconstruction of HIFU Focal Temperature Field Based on Deep Learning","authors":"Shunyao Luan, Yongshuo Ji, Yumei Liu, Linling Zhu, Haoyu Zhou, Jun Ouyang, Xiaofei Yang, Hong Zhao, Benpeng Zhu","doi":"10.34133/bmef.0037","DOIUrl":"https://doi.org/10.34133/bmef.0037","url":null,"abstract":"","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-Time Reconstruction of HIFU Focal Temperature Field Based on Deep Learning","authors":"Shunyao Luan, Yongshuo Ji, Yumei Liu, Linling Zhu, Haoyu Zhou, Jun Ouyang, Xiaofei Yang, Hong Zhao, Benpeng Zhu","doi":"10.34133/bmef.0037","DOIUrl":"https://doi.org/10.34133/bmef.0037","url":null,"abstract":"","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139842069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making “CASES” for AI in Medicine","authors":"Ge Wang","doi":"10.34133/bmef.0036","DOIUrl":"https://doi.org/10.34133/bmef.0036","url":null,"abstract":"","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139451881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}