Microbial Siderophores: A New Insight on Healthcare Applications.

IF 5 Q1 ENGINEERING, BIOMEDICAL
BME frontiers Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI:10.34133/bmef.0112
Shilpa Borehalli Mayegowda, Manjula Nagalapur Gadilingappa
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引用次数: 0

Abstract

Globally, increased illness and disorders have gained importance in improvising therapeutics to help extend the lifespan of an individual. In this scenario, understanding the mechanism of bacterial pathogenicity linked to the interaction between the host and the pathogen focusing on essential metal ions is necessary. Numerous studies indicate that the severity of a disease might be due to the reduced availability of iron, linked to abnormal production or lack of acquisition systems. However, several microbes produce siderophores as virulence factors, low-molecular-weight organic compounds for acquisition of iron by iron-chelating systems. In medical applications, siderophores are employed in novel strategies in order to design effective new drugs and vaccines, targeting and delivering antibiotics to target sites in multidrug-resistant pathogens. Meanwhile, some types of siderophores are used as drug delivery modalities and antimalarial, anticancer, and antibacterial agents, for example, by employing conjugation techniques such as Trojan horse delivery. Hence, the current review integrates several applications of siderophores with an overview covering taxonomy, organisms producing iron affinity carriers, and their acquisition mechanism. This understanding may delineate newer opportunities to adapt possible therapies and/or treatments against several multidrug-resistant pathogens, representing a crucial solution for public health problems worldwide.

微生物铁载体:医疗保健应用的新见解。
在全球范围内,疾病和失调的增加在即兴治疗中变得越来越重要,以帮助延长个体的寿命。在这种情况下,了解与宿主和病原体之间相互作用有关的细菌致病性机制是必要的,病原体聚焦于必需金属离子。许多研究表明,疾病的严重程度可能是由于铁的可用性减少,与异常生产或缺乏获取系统有关。然而,一些微生物产生铁载体作为毒力因子,通过铁螯合系统获取铁的低分子量有机化合物。在医疗应用中,铁载体被用于设计有效的新药物和疫苗的新策略,瞄准并将抗生素输送到多药耐药病原体的靶点。与此同时,某些类型的铁载体被用作药物递送方式和抗疟、抗癌和抗菌药物,例如通过采用诸如特洛伊木马递送之类的偶联技术。因此,本文综述了铁载体的分类、产生铁亲和载体的生物及其获取机制。这一认识可能为调整针对几种多重耐药病原体的可能疗法和/或治疗方法提供新的机会,是解决全球公共卫生问题的关键办法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.10
自引率
0.00%
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0
审稿时长
16 weeks
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