Biological psychiatry global open science最新文献

{"title":"Stress System Concordance: A Signature of Resilience","authors":"E. Ronald de Kloet , Marc L. Molendijk","doi":"10.1016/j.bpsgos.2024.100427","DOIUrl":"10.1016/j.bpsgos.2024.100427","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100427"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2667-1743(24)00152-6","DOIUrl":"10.1016/S2667-1743(24)00152-6","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100439"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Head Motion During Functional Magnetic Resonance Imaging Across Pediatric Neuropsychiatric Disorders","authors":"Tracey C. Shi ,&nbsp;Katherine Durham ,&nbsp;Rachel Marsh ,&nbsp;David Pagliaccio","doi":"10.1016/j.bpsgos.2024.100446","DOIUrl":"10.1016/j.bpsgos.2024.100446","url":null,"abstract":"<div><h3>Background</h3><div>Robust correction for head motion during functional magnetic resonance imaging is critical to avoid artifact-driven findings. Despite head motion differences across neuropsychiatric disorders, pediatric head motion across a range of diagnoses and covariates has not yet been evaluated. We tested 4 preregistered hypotheses: 1) externalizing disorder diagnoses will associate with more head motion during scanning; 2) internalizing disorder diagnoses will associate with less motion; 3) among children without attention-deficit/hyperactivity disorder, externalizing disorders will associate with more motion; and 4) among children with attention-deficit/hyperactivity disorder, comorbid internalizing disorders will associate with less motion.</div></div><div><h3>Methods</h3><div>Healthy Brain Network data releases 1.0–7.0 (<em>n</em> = 971) were analyzed in a discovery phase, and additional data released by February 29, 2024 (<em>n</em> = 437) were used in confirmatory analyses. Linear mixed-effects models were fitted with in-scanner head motion as the dependent variable. Binary independent variables of interest assessed for the presence or absence of externalizing or internalizing disorders.</div></div><div><h3>Results</h3><div>The confirmatory sample did not show significant associations between head motion and externalizing or internalizing disorders or support for the preregistered hypotheses. Across samples, there was a consistent interaction between age and neurodevelopmental diagnoses such that age-related decreases in head motion were attenuated in children with neurodevelopmental disorders.</div></div><div><h3>Conclusions</h3><div>Head motion remains an important confound in pediatric neuroimaging that may be associated with many factors, including neuropsychiatric symptoms, age, cognitive and physical attributes, and interactions among these variables. This work takes a step toward parsing these complex associations, focusing on neuropsychiatric diagnoses, age, and their interaction.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100446"},"PeriodicalIF":4.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiological Models of Hypersomnolence Associated With Depression","authors":"Christophe Moderie,&nbsp;Diane B. Boivin","doi":"10.1016/j.bpsgos.2024.100445","DOIUrl":"10.1016/j.bpsgos.2024.100445","url":null,"abstract":"<div><div>Up to 25% of patients with depression experience hypersomnolence (e.g., excessive daytime sleepiness, hypersomnia, and/or sleep inertia), which is associated with treatment resistance, overall poorer outcomes, and safety concerns while driving. Hypersomnolence can result from various sleep/neurological disorders or side effects from medication but is often medically unexplained in depression. In this review, we aimed to summarize the different pathophysiological models of hypersomnolence in depression to discuss their impact on nosology and to foster the development of better tailored diagnostics and treatments. We identified several potential mechanisms underlying hypersomnolence including a daytime hypoactivity of dopaminergic and noradrenergic systems, nighttime GABA (gamma-aminobutyric acid) hypoactivation, hypoperfusion, and hypoconnectivity in the medial prefrontal cortex, as well as a longer circadian period and light hyposensitivity. In some patients with depression, nighttime hyperarousal can fragment sleep and result in a complaint of excessive daytime sleepiness, thus mimicking hypersomnolence. Others might adopt maladaptive behaviors such as spending excessive time in bed, a term coined clinophilia. Objective markers of hypersomnolence, such as ambulatory ad libitum polysomnography may facilitate distinguishing between conditions that mimic hypersomnolence. Our review identified several clinical targets for hypersomnolence in depression. Low-sodium oxybate, which is approved for idiopathic hypersomnia, needs additional study in patients with depression. Neuromodulation that targets prefrontal cortex anomalies should be systematically explored, while tailored light therapy protocols may mitigate light hyposensitivity. Additionally, cognitive behavioral therapy for hypersomnolence is being developed as a nonpharmacological adjunct to these treatments.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100445"},"PeriodicalIF":4.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Health Across the Metabolic Spectrum","authors":"Vrinda Saxena ,&nbsp;Isaac Marin-Valencia","doi":"10.1016/j.bpsgos.2024.100443","DOIUrl":"10.1016/j.bpsgos.2024.100443","url":null,"abstract":"<div><div>Understanding the relationship between metabolism and mental health involves examining how disruptions in one system influence the other. The specific mechanisms by which metabolic processes impact the mind—and how mental well-being, in turn, affects metabolic regulation—are poorly understood. This shortcoming is attributable to the complex and multilayered nature of both the metabolic network and mental processes, as well as the lack of robust quantitative methods to analyze the workings of the mind. Inborn errors of metabolism exemplify this complexity, with over one-fourth being associated with psychiatric manifestations. Despite their high prevalence, psychiatric deficits in individuals with inborn errors of metabolism remain challenging to recognize and manage due to phenotypic variability, limited clinical training in neurometabolism, and gaps in research. To identify intersections between metabolism and mental health, here we assessed the effects of metabolic dysregulation on mental function, focusing on inborn errors of metabolism.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100443"},"PeriodicalIF":4.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents","authors":"Frank Mazza ,&nbsp;Alexandre Guet-McCreight ,&nbsp;Thomas D. Prevot ,&nbsp;Taufik Valiante ,&nbsp;Etienne Sibille ,&nbsp;Etay Hay","doi":"10.1016/j.bpsgos.2024.100435","DOIUrl":"10.1016/j.bpsgos.2024.100435","url":null,"abstract":"<div><h3>Background</h3><div>Reduced cortical inhibition mediated by GABA (gamma-aminobutyric acid) is reported in depression, anxiety disorders, and aging. A novel positive allosteric modulator that specifically targets the α5-GABA_A receptor subunit (α5-PAM), ligand GL-II-73 shows anxiolytic, antidepressant, and procognitive effects without the common side effects associated with nonspecific modulation by benzodiazepines such as diazepam, thus suggesting novel therapeutic potential. However, it is unknown whether α5-PAM has detectable signatures in clinically relevant brain electroencephalography (EEG).</div></div><div><h3>Methods</h3><div>We analyzed EEG in 10 freely moving rats at baseline and following injections of α5-PAM (GL-II-73) and diazepam.</div></div><div><h3>Results</h3><div>We showed that α5-PAM specifically decreased theta peak power, whereas diazepam shifted peak power from high to low theta while increasing beta and gamma power. EEG decomposition showed that these effects were periodic and corresponded to changes in theta oscillation event duration.</div></div><div><h3>Conclusions</h3><div>Thus, our study shows that α5-PAM has robust and distinct EEG biomarkers in rodents, indicating that EEG could enable noninvasive monitoring of α5-PAM treatment efficacy.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100435"},"PeriodicalIF":4.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Hallucinogen Rating Scale: Updated Factor Structure in a Large, Multistudy Sample","authors":"Abigail E. Calder ,&nbsp;Clifford Qualls ,&nbsp;Gregor Hasler ,&nbsp;David Elmiger ,&nbsp;Rick Strassman","doi":"10.1016/j.bpsgos.2024.100436","DOIUrl":"10.1016/j.bpsgos.2024.100436","url":null,"abstract":"<div><h3>Background</h3><div>The Hallucinogen Rating Scale (HRS) has been widely used to measure the subjective effects of psychedelics and other psychoactive substances. Its advantages include a basis in phenomenological interviews and clinical studies, straightforward items, and broad coverage of psychedelic effects. Previous studies have attempted to resolve its factor structure but were limited by small samples of participants who took only one substance.</div></div><div><h3>Methods</h3><div>We obtained 991 HRS questionnaires from the authors of 18 publications involving 13 psychoactive substances. Exploratory factor analysis was used to analyze its factor structure, and mixed-effects analyses of variance were used to compare HRS scores between drugs.</div></div><div><h3>Results</h3><div>The HRS resolved into 8 factors with good to excellent internal consistency and that intuitively map onto the effects of psychedelics. The factor model also showed good measures of fit that were superior to previous proposed models. Model factors were able to show dose responses for most drugs. Additionally, patterns of responses on the 8 factors significantly differentiated classic psychedelics, such as psilocybin and DMT, from other substance classes, including dissociatives such as ketamine and salvinorin A, empathogens such as MDMA, stimulants such as methylphenidate and amphetamine, and Δ⁹-tetrahydrocannabinol. The factor of meaningfulness also uniquely differentiated psychedelics from all other substances.</div></div><div><h3>Conclusions</h3><div>These data show that the HRS is an intuitive and psychometrically sound tool for measuring the effects of psychedelic drugs, and it may also have utility for measuring the effects of other drugs and altered states of consciousness.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100436"},"PeriodicalIF":4.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroconvulsive Therapy: A Scotland-Wide Naturalistic Study of 4826 Treatment Episodes","authors":"Julie Langan Martin ,&nbsp;Rona J. Strawbridge ,&nbsp;David Christmas ,&nbsp;Michael Fleming ,&nbsp;Stephen Kelly ,&nbsp;Daphne Varveris ,&nbsp;Daniel Martin","doi":"10.1016/j.bpsgos.2024.100434","DOIUrl":"10.1016/j.bpsgos.2024.100434","url":null,"abstract":"<div><h3>Background</h3><div>Electroconvulsive therapy (ECT) is an effective treatment option for several psychiatric disorders, including treatment-resistant depression, but there are concerns about potential adverse effects, particularly on cognition. This study describes ECT response and side effects in the Scottish ECT Audit Network.</div></div><div><h3>Methods</h3><div>Data collected from 4826 treatment episodes includes pre-ECT and post-ECT illness severity scores (Clinical Global Impression-Severity [CGI-S] and Montgomery–Åsberg Depression Rating Scale [MADRS]), diagnosis, age, sex, consent status, treatment year, treatment frequency, dose, and reported side effects. Descriptive statistics were used to assess the response to ECT by diagnosis, and logistic regression was used to investigate which factors influenced ECT response and side-effect occurrence.</div></div><div><h3>Results</h3><div>CGI-S scale scores were reduced after ECT in all diagnoses. For patients with depression or bipolar depression, MADRS scores were also reduced after ECT. The most common side effect was headaches (29%). Increased age and increased CGI-S scores were significantly associated (multiple-testing corrected <em>p</em> &lt; .05) with better treatment response and more cognitive side effects.</div></div><div><h3>Conclusions</h3><div>In a large observational outcome study of ECT, ECT appears to be effective (measured by reduction in CGI-S or MADRS scores) across a range of psychiatric diagnoses. Furthermore, increased age and increased illness severity scores at entry were the variables most significantly associated with treatment response and cognitive side effects.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100434"},"PeriodicalIF":4.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviors","authors":"Jennifer Blaze ,&nbsp;Viviana Dolores Evans ,&nbsp;Jessica Abigail Feria Pliego ,&nbsp;Petr Unichenko ,&nbsp;Behnam Javidfar ,&nbsp;Soeren Heissel ,&nbsp;Hanan Alwaseem ,&nbsp;Zachary Pennington ,&nbsp;Denise Cai ,&nbsp;Henrik Molina ,&nbsp;Christian Henneberger ,&nbsp;Schahram Akbarian","doi":"10.1016/j.bpsgos.2024.100432","DOIUrl":"10.1016/j.bpsgos.2024.100432","url":null,"abstract":"<div><h3>Background</h3><div>The presence of treatment resistance in neuropsychiatric disease suggests that novel mechanism-based discoveries and therapies could benefit the field, with a viable candidate being transfer RNA (tRNA) epitranscriptomics. <em>Nsun2</em> tRNA methyltransferase depletion in mature neurons elicits changes in complex behaviors relevant for fear, anxiety, and other neuropsychiatric phenotypes. However, it remains unclear whether this is due to dysregulated tRNAs or metabolic shifts that impact the neuronal translatome by activation of stress messengers together with alterations in amino acid supply.</div></div><div><h3>Methods</h3><div>To link specific molecular alterations resulting from neuronal <em>Nsun2</em> ablation to neuropsychiatric phenotypes, we used drug-induced phosphoactivation of stress response translation initiation factors together with disruption of NSUN2-regulated glycine tRNAs and cell type–specific ablation of the glycine cleavage system modeling the excessive upregulation of this amino acid in the <em>Nsun2</em>-deficient brain. Changes in extracellular glycine levels were monitored by an optical glycine Förster resonance energy transfer (FRET) sensor in the hippocampus, and behavioral phenotyping included cognition, anxiety-like behavior, and behavioral despair.</div></div><div><h3>Results</h3><div>Increased motivated escape behaviors were specifically observed in mice with neuron-specific ablation of <em>Gldc</em>, resulting in an excess in cortical glycine levels comparable to a similar phenotype in mice after deletion of neuronal <em>Nsun2</em>. None of these phenotypes were observed in mice treated with tunicamycin for chemoactivation of integrative stress response pathways or in mice genetically engineered for decreased glycine tRNA gene dosage. In the <em>Nsun2</em>-deficient brain, dynamic glycine profiles in the hippocampal extracellular space were fully maintained at baseline and in the context of neuronal activity.</div></div><div><h3>Conclusions</h3><div>Alterations in neuronal glycine metabolism, resulting from targeted ablation of the glycine cleavage system or disruption of the tRNA regulome, elicit changes in complex behaviors in mice relevant for neuropsychiatric phenotypes.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100432"},"PeriodicalIF":4.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating stress hormones, brain health, and cognition in healthy older adults: Cross-sectional findings and sex differences in AGE-WELL","authors":"Maxie Liebscher ,&nbsp;Silke White ,&nbsp;Anne Chocat ,&nbsp;Florence Mezenge ,&nbsp;Brigitte Landeau ,&nbsp;Marion Delarue ,&nbsp;Oriane Hébert ,&nbsp;Anne-Laure Turpin ,&nbsp;Natalie L. Marchant ,&nbsp;Gaël Chételat ,&nbsp;Olga Klimecki ,&nbsp;Géraldine Poisnel ,&nbsp;Miranka Wirth","doi":"10.1016/j.bpsgos.2024.100431","DOIUrl":"10.1016/j.bpsgos.2024.100431","url":null,"abstract":"<div><h3>Background</h3><div>Increased stress is a proposed risk factor for Alzheimer’s disease (AD). We examined the cross-sectional associations between circulating stress biomarkers and multimodal measures of brain health and cognition susceptible to AD in older adults and sex-specific subgroups.</div></div><div><h3>Methods</h3><div>Baseline data from 132 cognitively unimpaired non-depressed participants (age=74.0±4.0 years, women: n=80) in the Age-Well trial (NCT02977819) were included. Stress hormone levels were measured in overnight fasting blood serum (cortisol, dehydroepiandrosterone sulfate (DHEAS)) and blood plasma (epinephrine, norepinephrine) samples. AD-sensitive measures of brain health, including glucose metabolism (n=89), cerebral perfusion, gray matter volume, and amyloid deposition in a priori regions of interest, and cognitive markers were evaluated. Models were adjusted for age, sex, education, trait anxiety, and depressive symptoms.</div></div><div><h3>Results</h3><div>Higher epinephrine was associated (<em>pFDR</em>&lt;0.05) with lower glucose metabolism in the anterior cingulate cortex (ACC, β=-0.26, <em>p</em>=.008), posterior cingulate cortex (PCC, β=-0.32, <em>p</em>=.006) and precuneus (β=-0.27, <em>p</em>=.021) and lower perfusion in the PCC (β=-0.23, <em>p</em>=.013). Interactions between stress hormones and sex showed (<em>pFDR</em>&lt;0.05) that in women only, higher epinephrine was associated with larger ACC volume (interaction: β=0.32, <em>p</em>=.016), whereas in men only, higher cortisol was associated with lower episodic memory performance (interaction: β=0.98, <em>p</em>=.012).</div></div><div><h3>Conclusions</h3><div>The present study demonstrates the involvement of circulating stress hormones, particularly epinephrine and cortisol, in higher resilience or vulnerability of brain health and cognition indicators susceptible to AD in older adults. The identification of sex-specific patterns in these associations may inform the development of more effective and tailored interventions.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100431"},"PeriodicalIF":4.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}