Biological psychiatry global open science最新文献

{"title":"Investigating the Shared Genetic Architecture Between Psychiatric Disorders and Executive Function","authors":"Sijie Zhang ,&nbsp;Linlin Zhao ,&nbsp;Aijun Liao ,&nbsp;David Li ,&nbsp;Hong Li ,&nbsp;Lijun Ouyang ,&nbsp;Xiaogang Chen ,&nbsp;Zongchang Li","doi":"10.1016/j.bpsgos.2024.100392","DOIUrl":"10.1016/j.bpsgos.2024.100392","url":null,"abstract":"<div><h3>Background</h3><div>Evidence for widespread comorbidity of executive dysfunctions with psychiatric disorders suggests common mechanisms underlying their pathophysiology. However, the shared genetic architectures between psychiatric disorders and executive function (EF) remain poorly understood.</div></div><div><h3>Methods</h3><div>Leveraging large genome-wide association study datasets of European ancestry on bipolar disorder (<em>N</em> = 353,899), major depressive disorder (<em>N</em> = 674,452), and schizophrenia (<em>N</em> = 130,644) from the Psychiatric Genomics Consortium and iPSYCH and a common factor of EF (<em>N</em> = 427,037) from UK Biobank, we systematically investigated the shared genomic architectures between psychiatric disorders and EF with a set of statistical genetic, functional genomic, and gene-level analyses.</div></div><div><h3>Results</h3><div>Our study demonstrated substantial genetic overlaps and significant genetic correlations between psychiatric disorders and EF. EF showed an estimated 95.9%, 98.1%, and 99.2% of phenotype-influencing variants, as well as 50, 23, and 130 genomic loci shared with bipolar disorder, major depressive disorder, and schizophrenia, respectively. Single nucleotide polymorphism heritability enrichment suggests that the genetic architecture of psychiatric disorders and EF involves the brain’s frontal cortex and prefrontal glutamatergic neurons 1 and 2. Functional genomic analysis of shared variants identified 12 functional regulatory variants that regulate gene expression by affecting the binding affinities of 5 transcription factors. In addition, functional characterization analyses of shared genes revealed potential common biological mechanisms related to synaptic processes and fetal brain development.</div></div><div><h3>Conclusions</h3><div>Our findings provide evidence for extensive shared genetic architectures between psychiatric disorders and EF and have valuable implications for future mechanistic investigations and drug development efforts.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100392"},"PeriodicalIF":4.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Size and Topography of the Brain’s Functional Networks with Psychotic Experiences, Schizophrenia, and Bipolar Disorder","authors":"Daniel Mamah ,&nbsp;Shing Shiun Chen ,&nbsp;Evan Gordon ,&nbsp;Sridhar Kandala ,&nbsp;Deanna M. Barch ,&nbsp;Michael P. Harms","doi":"10.1016/j.bpsgos.2024.100386","DOIUrl":"10.1016/j.bpsgos.2024.100386","url":null,"abstract":"<div><h3>Background</h3><div>Existing functional connectivity studies of psychosis use population-averaged functional network maps, despite highly variable topographies of these networks across the brain surface. We aimed to define the functional network areas and topographies in the general population and the changes associated with psychotic experiences (PEs) and disorders.</div></div><div><h3>Methods</h3><div>Maps of 8 functional networks were generated using an individual-specific template-matching procedure for each participant from the Human Connectome Project Young Adult cohort (<em>n</em> = 1003) and from a matched case cohort (schizophrenia [SCZ], <em>n</em> = 27; bipolar disorder, <em>n</em> = 35) scanned identically with the same Connectom scanner. In the Human Connectome Project Young Adult cohort, PEs were estimated based on scores from the Achenbach Self-Report Scale. The relationship of symptoms to the probability of network representation at each cortical vertex was assessed using logistic regression.</div></div><div><h3>Results</h3><div>In Human Connectome Project Young Adult participants, PE severity on the Achenbach thought problems scale was predicted by increased language network (LAN) and dorsal attention network (DAN) areas and decreased cingulo-opercular network area (<em>r</em> &lt; 0.12). Significant effects were found in SCZ, with a larger DAN and LAN and a smaller frontoparietal network. Network pattern analysis in SCZ showed an increased probability of LAN in the posterior region of the left superior temporal gyrus and of the visual network in the left insula. Regression analyses in SCZ found that mood dysregulation was related to increased DAN surface area.</div></div><div><h3>Conclusions</h3><div>Those with PEs and SCZ showed abnormal functional network cortical topographies, particularly involving DAN and LAN. Network findings may predict psychosis progression and guide earlier intervention.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100386"},"PeriodicalIF":4.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Screening for X Chromosome Parent-of-Origin Effects on Neurobehavioral and Neuroanatomical Phenotypes in 47,XXY Klinefelter Syndrome","authors":"Isabella G. Larsen ,&nbsp;Rachel Gore Moses ,&nbsp;Bryce A. Seifert ,&nbsp;Siyuan Liu ,&nbsp;Samuel Li ,&nbsp;Andrew J. Oler ,&nbsp;Elizabeth Levitis ,&nbsp;Lukas Schaffer ,&nbsp;Rylee Duncan ,&nbsp;Colleen Jodarski ,&nbsp;Michael Kamen ,&nbsp;Jia Yan ,&nbsp;François M. Lalonde ,&nbsp;Rajarshi Ghosh ,&nbsp;Erin Torres ,&nbsp;Liv S. Clasen ,&nbsp;Jonathan Blumenthal ,&nbsp;Morgan Similuk ,&nbsp;Armin Raznahan ,&nbsp;Magdalena A. Walkiewicz","doi":"10.1016/j.bpsgos.2024.100391","DOIUrl":"10.1016/j.bpsgos.2024.100391","url":null,"abstract":"<div><h3>Background</h3><div>X chromosome parent of origin (POX) has been proposed as a source of phenotypic variation within sex chromosome aneuploidies such as Klinefelter syndrome (XXY/KS) and between XX and XY individuals. However, previous studies have yielded conflicting results regarding the presence and nature of POX effects, which we sought to clarify in an expanded sample with deeper neurobehavioral phenotyping.</div></div><div><h3>Methods</h3><div>A cohort of 58 individuals with XXY/KS underwent duo or trio genome sequencing with parents (<em>n</em> = 151), measurement of 66 neurobehavioral phenotypes by standardized research assessments, and measurement of over 1000 anatomical phenotypes by structural magnetic resonance imaging. We developed a novel algorithm, the uniparental disomy visualization for variant call format files, to determine proband POX and then systematically tested for POX associations with all neurobehavioral and neuroanatomical outcomes.</div></div><div><h3>Results</h3><div>The uniparental disomy visualization for variant call format files algorithm showed maternal POX in 35 of 58 cases (60.3%). There were no statistically significant POX effects on any of the 66 subscale measures of cognition, psychopathology, or behavior. Neuroimaging analysis identified 2 regions in the right hemisphere with significantly higher surface area (mean effect size = 1.20) among individuals with paternal versus maternal POX (<em>q</em> = .021).</div></div><div><h3>Conclusions</h3><div>Using deeper phenotyping in an expanded sample, we did not find evidence for substantial POX effects on neurobehavioral variability, except for localized unilateral modulations of surface area in the absence of co-occurring behavioral associations. These findings help to clarify previous inconsistencies in POX research and direct attention toward other sources of clinical variability in sex chromosome aneuploidies.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100391"},"PeriodicalIF":4.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness Training in High-Demand Cohorts Alters Resting-State Electroencephalography: An Exploratory Investigation of Individual Alpha Frequency, Aperiodic 1/f Activity, and Microstates","authors":"Chloe A. Dziego ,&nbsp;Anthony P. Zanesco ,&nbsp;Ina Bornkessel-Schlesewsky ,&nbsp;Matthias Schlesewsky ,&nbsp;Elizabeth A. Stanley ,&nbsp;Amishi P. Jha","doi":"10.1016/j.bpsgos.2024.100383","DOIUrl":"10.1016/j.bpsgos.2024.100383","url":null,"abstract":"<div><h3>Background</h3><div>Mindfulness training (MT) programs have demonstrated utility as cognitive training tools, but there is little consensus on the neurophysiological processes that may underlie its benefits. It has been posited that intrinsic brain activity recorded at rest reflects the functional connectivity of large-scale brain networks and may provide insight into neuroplastic changes that support MT. In the current study, we indexed changes in several resting-state electroencephalography (EEG) parameters to investigate the neurophysiological underpinnings of MT.</div></div><div><h3>Methods</h3><div>Resting-state EEG data were collected from active-duty U.S. military personnel (<em>N</em> = 80) at 2 testing sessions: before (time [T] 1) and after (T2) engaging in an 8-week MT or active comparison intervention (positivity training). We examined longitudinal and/or groupwise differences in several EEG parameters through parameterization of power spectra (individual alpha frequency and 1/<em>f</em> activity) and microstate analysis.</div></div><div><h3>Results</h3><div>While no significant group × time differences were observed in individual alpha frequency, significant group × time effects were observed in several EEG parameters from T1 to T2. Compared with MT, positivity training was associated with a steepening of the 1/<em>f</em> slope and higher 1/<em>f</em> intercepts together with decreased duration and increased global field power of microstates.</div></div><div><h3>Conclusions</h3><div>Taken together, these results suggest that the effects of interventions may be differentiated in resting-state brain activity in a sample of military personnel. Such findings provide insight into the neural underpinnings of MT-related brain changes, but more research is required to elucidate how these may relate to task-related neural and performance changes with MT and whether results generalize to other mindfulness interventions in alternative cohorts and contexts.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100383"},"PeriodicalIF":4.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling Autism: Using Brain Organoids to Investigate Sex Differences in Brain Development","authors":"Max Mitchell ,&nbsp;Aleksandra Spasova ,&nbsp;Yasir Ahmed Syed","doi":"10.1016/j.bpsgos.2024.100360","DOIUrl":"10.1016/j.bpsgos.2024.100360","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100360"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000739/pdfft?md5=bc500a2ce56e3353322cc205a4404926&pid=1-s2.0-S2667174324000739-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Awe and Other Psychological Factors in Ketamine’s Mechanism of Antidepressant Action","authors":"Mina Ansari,&nbsp;Gerard Sanacora","doi":"10.1016/j.bpsgos.2024.100353","DOIUrl":"10.1016/j.bpsgos.2024.100353","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100353"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000661/pdfft?md5=924fa03072b6fb44d861a5f3b5ba472c&pid=1-s2.0-S2667174324000661-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2667-1743(24)00091-0","DOIUrl":"10.1016/S2667-1743(24)00091-0","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100378"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000910/pdfft?md5=6a74f031fb574bfb7000fd1611e85e4f&pid=1-s2.0-S2667174324000910-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Deep Structures to Noninvasively Modulate Fear and Anxiety","authors":"Odile A. van den Heuvel","doi":"10.1016/j.bpsgos.2024.100363","DOIUrl":"10.1016/j.bpsgos.2024.100363","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100363"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000764/pdfft?md5=43def89ddc2febe61c7dd1e0fcdf8600&pid=1-s2.0-S2667174324000764-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S2667-1743(24)00092-2","DOIUrl":"10.1016/S2667-1743(24)00092-2","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100379"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000922/pdfft?md5=8a2165ec857ba0671393b030659b1bd9&pid=1-s2.0-S2667174324000922-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobiological Underpinnings of Adolescent Susceptibility to Stress","authors":"Patricio O’Donnell","doi":"10.1016/j.bpsgos.2024.100364","DOIUrl":"10.1016/j.bpsgos.2024.100364","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100364"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000776/pdfft?md5=1d3fff78f9f4487e8d581b0ac1ca8851&pid=1-s2.0-S2667174324000776-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}