Biological psychiatry global open science最新文献

{"title":"Reducing NMDA Receptor Function Impacting Learning and Electroencephalogram Oscillations","authors":"Tyler D. Dexter , Jared W. Young","doi":"10.1016/j.bpsgos.2025.100542","DOIUrl":"10.1016/j.bpsgos.2025.100542","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100542"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder.","authors":"Nigussie T Sharew, Scott R Clark, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Janice M Fullerton, Liping Hou, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, Roland Hasler, Hélène Richard-Lepouriel, Nader Perroud, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M Czerski, Nina Dalkner, Maria Del Zompo, J Raymond DePaulo, Bruno Étain, Stephane Jamain, Peter Falkai, Andreas J Forstner, Louise Frisen, Mark A Frye, Sébastien Gard, Julie S Garnham, Fernando S Goes, Maria Grigoroiu-Serbanescu, Andreas J Fallgatter, Sophia Stegmaier, Thomas Ethofer, Silvia Biere, Kristiyana Petrova, Ceylan Schuster, Kristina Adorjan, Monika Budde, Maria Heilbronner, Janos L Kalman, Mojtaba Oraki Kohshour, Daniela Reich-Erkelenz, Sabrina K Schaupp, Eva C Schulte, Fanny Senner, Thomas Vogl, Ion-George Anghelescu, Volker Arolt, Udo Dannlowski, Detlef E Dietrich, Christian Figge, Markus Jäger, Fabian U Lang, Georg Juckel, Carsten Konrad, Jens Reimer, Max Schmauß, Andrea Schmitt, Carsten Spitzer, Martin von Hagen, Jens Wiltfang, Jörg Zimmermann, Till F M Andlauer, Andre Fischer, Felix Bermpohl, Philipp Ritter, Silke Matura, Anna Gryaznova, Irina Falkenberg, Cüneyt Yildiz, Tilo Kircher, Julia Schmidt, Marius Koch, Kathrin Gade, Sarah Trost, Ida S Haussleiter, Martin Lambert, Anja C Rohenkohl, Vivien Kraft, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J McCarthy, Susan McElroy, Francesc Colom, Vincent Millischer, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Markus M Nöthen, Tomas Novák, Claire O'Donovan, Norio Ozaki, Andrea Pfennig, Claudia Pisanu, James B Potash, Andreas Reif, Eva Reininghaus, Guy A Rouleau, Janusz K Rybakowski, Martin Schalling, Peter R Schofield, Barbara W Schweizer, Giovanni Severino, Paul D Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Biju Viswanath, Stephanie H Witt, Adam Wright, Peter P Zandi, Philip B Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J McMahon, Thomas G Schulze, Bernhard T Baune, Klaus Oliver Schubert, Azmeraw T Amare","doi":"10.1016/j.bpsgos.2025.100558","DOIUrl":"10.1016/j.bpsgos.2025.100558","url":null,"abstract":"<p><strong>Background: </strong>Polygenic scores (PGSs) hold the potential to identify patients who respond favorably to specific psychiatric treatments. However, their biological interpretation remains unclear. In this study, we developed pathway-specific PGSs (PS_PGSs) for lithium response and assessed their association with clinical lithium response in patients with bipolar disorder.</p><p><strong>Methods: </strong>Using sets of genes involved in pathways affected by lithium, we developed 9 PS_PGSs and evaluated their associations with lithium response in the International Consortium on Lithium Genetics (ConLi⁺Gen) (<i>N</i> = 2367), with validation in combined PsyCourse (Pathomechanisms and Signatures in the Longitudinal Course of Psychosis) (<i>N</i> = 105) and BipoLife (<i>N</i> = 102) cohorts. The association between each PS_PGS and lithium response-defined both as a continuous ALDA score and a categorical outcome (good vs. poor responses)-was evaluated using regression models, with adjustment for confounders. The cutoff for a significant association was <i>p</i> < .05 after multiple testing correction.</p><p><strong>Results: </strong>The PGSs for acetylcholine, GABA (gamma-aminobutyric acid), and mitochondria were associated with response to lithium in both categorical and continuous outcomes. However, the PGSs for calcium channel, circadian rhythm, and GSK (glycogen synthase kinase) were associated only with the continuous outcome. Each score explained 0.29% to 1.91% of the variance in the categorical and 0.30% to 1.54% of the variance in the continuous outcomes. A multivariate model combining PS_PGSs that showed significant associations in the univariate analysis (combined PS_PGS) increased the percentage of variance explained (<i>R</i> ²) to 3.71% and 3.18% for the categorical and continuous outcomes, respectively. Associations for PGSs for GABA and circadian rhythm were replicated. Patients with the highest genetic loading (10th decile) for acetylcholine variants were 3.03 times more likely (95% CI, 1.95 to 4.69) to show a good lithium response (categorical outcome) than patients with the lowest genetic loading (1st decile).</p><p><strong>Conclusions: </strong>PS_PGSs achieved predictive performance comparable to the conventional genome-wide PGSs, with the added advantage of biological interpretability using a smaller list of genetic variants.</p>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"100558"},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Volume Reductions and Relationship With Depression and Cognitive Functioning in Suicide in Older Adults: A Cross-Sectional and Longitudinal Study Using Bayesian Multilevel Modeling","authors":"Vanessa M. Brown ,&nbsp;Swathi Gujral ,&nbsp;Ya-Wen Chang ,&nbsp;Hanga Galfalvy ,&nbsp;Katalin Szanto ,&nbsp;Alexandre Y. Dombrovski","doi":"10.1016/j.bpsgos.2025.100552","DOIUrl":"10.1016/j.bpsgos.2025.100552","url":null,"abstract":"<div><h3>Background</h3><div>In older adults, depression with cognitive impairment may be a harbinger of early dementia and a risk factor for suicidal behavior. However, the neuroanatomical correlates of these impairments are unknown, particularly when examined longitudinally.</div></div><div><h3>Methods</h3><div>Older adults (<em>N</em> = 153, mean [SD] age = 62.8 [7.7] years; 86/67 [56%/44%] female/male) with either a history of suicide attempts (<em>n</em> = 46), depression with no history of suicide attempts (<em>n</em> = 72), or no psychiatric history (<em>n</em> = 35) completed T1 structural magnetic resonance imaging scans. Of these participants, 51 had repeated scans (days between scans mean [SD] = 415 [252], range = 90–1091). Bayesian multilevel modeling with false discovery rate correction tested cross-sectional group differences and prospective changes in brain volumes as a function of suicide attempt history, depression severity, and cognitive functioning.</div></div><div><h3>Results</h3><div>Three broad categories of individual differences emerged: 1) a history of attempted suicide and impaired executive functioning related to and predicted volumes in temporal areas, neighboring parietal and occipital regions, and the hippocampus; 2) frontal and subcortical volume reductions related to depression, particularly current episode severity; and 3) cognitive impairment typical of cortical dementia predicted medial temporal volume reduction.</div></div><div><h3>Conclusions</h3><div>A history of suicidal behavior, depression, and dementia-related cognitive decline are accompanied by reduced brain volumes in largely non-overlapping regions that nevertheless converge on the hippocampus. The hippocampus may be a nexus where independent changes associated with depression and suicide diathesis factors co-occur with dementia-related neurodegeneration. These results support distinct neurocognitive deficits in late-life suicide in older adults. A better understanding of hippocampal structure and function in people at risk of suicide will advance both risk prediction and treatment development.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100552"},"PeriodicalIF":3.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No Laughing Matter: Nitrous Oxide and Depression","authors":"Ella Williams ,&nbsp;Philip J. Cowen","doi":"10.1016/j.bpsgos.2025.100551","DOIUrl":"10.1016/j.bpsgos.2025.100551","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100551"},"PeriodicalIF":4.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextualizing Telomere Biology Through Biopsychological Plasticity: Insights From the Differential Susceptibility Hypothesis","authors":"Erika Comasco","doi":"10.1016/j.bpsgos.2025.100548","DOIUrl":"10.1016/j.bpsgos.2025.100548","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100548"},"PeriodicalIF":4.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Brain Correlates of Multidomain Resilience Among Youth Exposed to Neighborhood Disadvantage","authors":"Gabriela L. Suarez ,&nbsp;Jessica L. Bezek ,&nbsp;Heidi B. Westerman ,&nbsp;Jamie L. Hanson ,&nbsp;Kelly L. Klump ,&nbsp;S. Alexandra Burt ,&nbsp;Luke W. Hyde","doi":"10.1016/j.bpsgos.2025.100550","DOIUrl":"10.1016/j.bpsgos.2025.100550","url":null,"abstract":"<div><h3>Background</h3><div>Many youth exposed to adversity exhibit resilience, yet the neurobiological factors that support resilience are poorly understood. Few studies have examined how brain structure is related to resilience across multiple domains of functioning.</div></div><div><h3>Methods</h3><div>We evaluated associations between brain structure (volume, thickness, surface area) and psychological, social, and academic resilience in a sample of 708 twins (7–19 years) exposed to neighborhood disadvantage from the Michigan Twin Neurogenetics Study, recruited from the Michigan State University Twin Registry.</div></div><div><h3>Results</h3><div>For youth exposed to neighborhood disadvantage, greater total gray matter volume predicted positive psychological adaptation, while smaller right caudal middle frontal gyrus surface area predicted positive social adaptation. We examined whether cumulative adverse experiences moderated the relationship between brain structure and positive outcomes. Several interactions between brain structure and cumulative risk were found to predict positive outcomes, yielding multidomain resilience. Generally, larger brain structure correlated with increased positive functioning in specific domains for individuals with high cumulative risk but not for those with low cumulative risk.</div></div><div><h3>Conclusions</h3><div>The study supports the use of multidomain resilience models and identifies neural mechanisms that may promote adaptive responses to adversity. Most identified structural correlates of positive adaptation were indicators of resilience in that they predicted positive function at moderate to high levels of exposure to cumulative risk.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100550"},"PeriodicalIF":4.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward an Experimental Model to Study Dissociation in the Laboratory: Current Challenges and a Path Forward","authors":"Johannes B. Heekerens ,&nbsp;Christian Schmahl","doi":"10.1016/j.bpsgos.2025.100549","DOIUrl":"10.1016/j.bpsgos.2025.100549","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100549"},"PeriodicalIF":4.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilayered Epigenetic Analysis Identifies a Molecular Portrait for Psychological Resilience in Patients With Breast Cancer","authors":"Corinna Richter ,&nbsp;Olga Dethlefsen ,&nbsp;Ulrika Axelsson ,&nbsp;Kristina Lundberg ,&nbsp;Lisa Rydén ,&nbsp;Per Johnsson ,&nbsp;Ulrika Ringdahl ,&nbsp;Ingalill Rahm Hallberg ,&nbsp;Carl A.K. Borrebaeck","doi":"10.1016/j.bpsgos.2025.100545","DOIUrl":"10.1016/j.bpsgos.2025.100545","url":null,"abstract":"<div><h3>Background</h3><div>Psychological resilience refers to a person’s positive adaptation when faced with adversities, such as a breast cancer (BC) diagnosis. Highly resilient patients are more likely to regain stability and be protected from health conditions such as depression, anxiety, and posttraumatic stress disorder. We aimed to identify epigenetic markers that distinguish high- and low-resilient patients in a BC cohort at time of diagnosis.</div></div><div><h3>Methods</h3><div>Genome-wide DNA methylation was determined in participants selected from a prospectively collected cohort of 1040 newly diagnosed BC patients with known resilience status. DNA methylation of those displaying the highest and lowest scores (<em>n</em> = 425), as measured by the Connor-Davidson Resilience Scale, was analyzed in whole blood, using a multilayered bioinformatic approach. Sample subsets were created to identify differentially methylated probes (DMPs) and differentially methylated regions (DMRs), and fold change and area size were used to estimate the strength of methylation differences. The key regions associated with psychological resilience allowed us to build a classifier, using a random forest model, which was validated using an independent cohort (<em>n</em> = 80).</div></div><div><h3>Results</h3><div>DMPs and DMRs that consistently distinguished samples derived from high- and low-resilient patients were identified, and methylation differences followed a dose-response pattern related to resilience levels. DMRs included <em>LY6G5C, ZFP57, CDH9, ZNF727</em>, and <em>C8orf31</em>, where <em>LY6G5C</em> was found to be the most consistent DMR. Psychological resilience status could be predicted in the independent cohort with an area under the curve of 0.74 and a sensitivity and specificity of 0.67 and 0.72, respectively.</div></div><div><h3>Conclusions</h3><div><em>LY6G5C</em> was identified as a novel marker for psychological resilience, paving the way for a more conceptual and comprehensive molecular understanding.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100545"},"PeriodicalIF":4.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence","authors":"Jessica Morrel ,&nbsp;L. Nate Overholtzer ,&nbsp;Kirthana Sukumaran ,&nbsp;Devyn L. Cotter ,&nbsp;Carlos Cardenas-Iniguez ,&nbsp;J. Michael Tyszka ,&nbsp;Joel Schwartz ,&nbsp;Daniel A. Hackman ,&nbsp;Jiu-Chiuan Chen ,&nbsp;Megan M. Herting","doi":"10.1016/j.bpsgos.2025.100544","DOIUrl":"10.1016/j.bpsgos.2025.100544","url":null,"abstract":"<div><h3>Background</h3><div>Outdoor air pollution exposure is associated with structural and functional brain differences and an increased risk for psychopathology. Although the neural mechanisms remain unclear, air pollutants may impact mental health by altering brain regions implicated in psychopathology, such as the amygdala. Here, we examined the association between ambient air pollution exposure and amygdala subregion volumes in 9- to 10-year-olds.</div></div><div><h3>Methods</h3><div>Cross-sectional data from 4473 (55.4% male) Adolescent Brain Cognitive Development (ABCD) Study participants were leveraged. Air pollution exposure was estimated based on each participant’s primary residential address. Using the CIT168 atlas, we quantified total amygdala and 9 subregion volumes from T1- and T2-weighted images. We investigated associations between criteria pollutants (i.e., fine particulate matter [PM_2.5], nitrogen dioxide, and ground-level ozone), 15 PM_2.5 components, and amygdala subregion volumes and relative volume fractions using both single-pollutant linear mixed-effects regression and partial least squares correlation (PLSC) co-exposure modeling approaches.</div></div><div><h3>Results</h3><div>No significant associations were detected using single-pollutant models. Rather, in examining mixtures of exposures with PLSC, 1 latent dimension (52% variance explained) captured a positive association between calcium and several basolateral subregions. Latent dimensions were also identified for amygdala relative volume fractions (ranging from 30% to 82% variance explained), with PM_2.5 and component co-exposure being associated with increases in lateral, but decreases in medial and central, relative volume fractions.</div></div><div><h3>Conclusions</h3><div>PM_2.5 and its components are associated with distinct amygdala differences, potentially playing a role in risk for adolescent mental health problems.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100544"},"PeriodicalIF":4.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White Blood Cell Proportions Are Associated With Response to Psychosocial Therapy in Young People at Ultra-High Risk for Psychosis","authors":"Lauren F. Barker ,&nbsp;Allan F. McRae ,&nbsp;Hok Pan Yuen ,&nbsp;Anjali K. Henders ,&nbsp;Leanne M. Wallace ,&nbsp;Tian Lin ,&nbsp;Christina Phassouliotis ,&nbsp;Jessica Spark ,&nbsp;Melissa Kerr ,&nbsp;Enda M. Byrne ,&nbsp;G. Paul Amminger ,&nbsp;Barnaby Nelson ,&nbsp;Naomi R. Wray ,&nbsp;Patrick D. McGorry","doi":"10.1016/j.bpsgos.2025.100546","DOIUrl":"10.1016/j.bpsgos.2025.100546","url":null,"abstract":"<div><h3>Background</h3><div>White blood cell (WBC) counts, DNA methylation, and gene expression are reported to be associated with psychosis. However, it is not known whether these associations precede the onset of psychosis or whether they are relevant for the stratification of psychosis risk in clinically high-risk individuals. The STEP (Staged Treatment in Early Psychosis) clinical trial evaluated the effectiveness of a sequential intervention strategy for preventing psychosis in a cohort of young people at ultra-high risk (UHR) of psychosis. Participants were assessed for remission of UHR status after up to 6 months of treatment with psychosocial therapy.</div></div><div><h3>Methods</h3><div>Cell-type proportions estimated from whole-blood DNA methylation samples (<em>N</em> = 91) were used to test for associations between WBC proportions at trial baseline and remission of UHR status (31 remitters, 60 nonremitters), including at which step of the trial remission occurred. DNA methylome-wide association and differential expression analyses were conducted to test for associations with remission of UHR status.</div></div><div><h3>Results</h3><div>Baseline lymphocyte cell proportions (odds ratio [OR], 0.23; 95% CI, 0.07–0.62; <em>p</em> = 9.2 × 10⁻³) and neutrophil-lymphocyte ratio (OR, 2.9; 95% CI, 1.37–7.46; <em>p</em> = .012) were significantly associated with remission status. There were suggestive associations between specific cell types and the timing of remission during the trial; however, these did not survive correction for multiple testing. No methylation probes or differentially expressed genes were associated with remission status when cell-type proportions were included as covariates.</div></div><div><h3>Conclusions</h3><div>Our results indicate the potential importance of WBCs for further stratification of psychosis risk in UHR individuals and reinforce the importance of routine collection of WBC data for future clinical trials.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100546"},"PeriodicalIF":4.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}