Biological psychiatry global open science最新文献

{"title":"Neurocognitive Biotypes of Risk and Resilience for Mood Disorders in Adolescents: Insights From Behavioral and Graph-Theoretic Network Markers","authors":"Ambra Coccaro ,&nbsp;Ziwei Cheng ,&nbsp;Luka Ruzic ,&nbsp;Amelia D. Moser ,&nbsp;Jenna Jones ,&nbsp;Elena C. Peterson ,&nbsp;Elisa F. Stern ,&nbsp;Naomi P. Friedman ,&nbsp;Roselinde H. Kaiser","doi":"10.1016/j.bpsgos.2025.100563","DOIUrl":"10.1016/j.bpsgos.2025.100563","url":null,"abstract":"<div><h3>Background</h3><div>Adolescence is a developmental period of increased prevalence of mood disorders, but identifying adolescents who are at risk for or resilient to mood pathology remains a clinical challenge. In the current study, we addressed this challenge by evaluating multidimensional profiles of neurocognitive functioning (biotypes) that may confer vulnerability or protect against psychopathology. Biotypes were derived from neurocognitive data and identified as being resilient or high risk based on their association with future symptoms.</div></div><div><h3>Methods</h3><div>Adolescents (<em>N</em> = 146; 13–21 years, 66% first-degree familial history of mood disorders) completed behavioral tests and magnetic resonance imaging at baseline. Biotypes were derived using cluster analysis on measures of reward sensitivity and executive functioning. Over 2 years, participants reported on subjective life stress and symptoms of anhedonia or mania/hypomania. Regression analyses were used to test biotype differences in symptom variability (lability in mood symptoms) and life stress as a moderator of biotype-related differences.</div></div><div><h3>Results</h3><div>Biotype 1 (high executive functions, balanced integration/segregation of functional brain networks) was resilient: adolescents in this biotype reported low symptom variability, even under heightened life stress. Adolescents in biotype 2 (poor executive functions, low frontoparietal modularity) reported higher variability in symptoms of mania/hypomania overall. Adolescents in biotype 3 (mixed reward sensitivity, high overall network modularity) reported high variability in symptoms of anhedonia and mania/hypomania, if also reporting heightened life stress. Adolescents in biotype 4 (blunted reward decision processing, hyperconnected networks) reported high variability in symptoms of anhedonia, if also reporting heightened life stress.</div></div><div><h3>Conclusions</h3><div>Neurocognitive biotypes may identify adolescents who are resilient to, or at risk for, mood pathology.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100563"},"PeriodicalIF":3.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brainwide Analysis of Functional Connectivity Patterns in Specific Phobia and Its Treatment","authors":"Markus Muehlhan ,&nbsp;Judith Schäfer ,&nbsp;Kevin Hilbert ,&nbsp;Esther Seidl ,&nbsp;Katja Beesdo-Baum","doi":"10.1016/j.bpsgos.2025.100562","DOIUrl":"10.1016/j.bpsgos.2025.100562","url":null,"abstract":"<div><h3>Background</h3><div>Specific phobia (SP) is a prevalent mental disorder for which exposure-based treatments are the most effective. Little is known about the intrinsic functional connectivity of SP and its modification by treatment. While previous studies were limited to a priori–defined brain regions, we used connectome-wide analyses to capture the full extent of altered functional connectivity.</div></div><div><h3>Methods</h3><div>We used functional magnetic resonance imaging in combination with hypothesis-free, data-driven functional connectivity multivariate pattern analysis (fc-MVPA) to identify differences between 72 individuals with SP and a nonphobic control group (CG) (<em>n</em> = 82). The SP group then received a one-session exposure treatment and was scanned again 9 weeks later on average.</div></div><div><h3>Results</h3><div>fc-MVPA identified the largest differences between the SP group and CG in sensorimotor regions, with lower connectivity to temporal nodes of the default network and anticorrelations with the frontoparietal network in the SP group compared with the CG. Stronger connectivity in the pretreatment compared with the posttreatment condition was evident in visual regions, while anticorrelations with the frontoparietal network were reduced. Post hoc comparisons showed that the connectivity strengths of the SP group after treatment between almost all identified nodes of both contrasts (SP vs. CG and pre vs. post) were comparable to those of the CG at baseline.</div></div><div><h3>Conclusions</h3><div>Given the known functions of the identified networks, it is possible that the changes in connectivity measured after treatment indicate improved action control, enabled by more accurate prediction of the environment and stronger coupling of perceptual and action regions with higher-order control regions.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100562"},"PeriodicalIF":3.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Series of Young People Receiving Adjunctive Immunotherapy for Neuroimmune-Mediated Major Mood or Psychotic Syndromes","authors":"Elizabeth M. Scott ,&nbsp;David A. Brown ,&nbsp;Cathrin Rohleder ,&nbsp;Mirim Shin ,&nbsp;Shin H. Park ,&nbsp;Ian B. Hickie","doi":"10.1016/j.bpsgos.2025.100564","DOIUrl":"10.1016/j.bpsgos.2025.100564","url":null,"abstract":"<div><h3>Background</h3><div>Neuroimmune processes are often implicated in young people with atypical neuropsychiatric disorders, yet treatment implications remain controversial. This case series details young people with primary psychiatric disorders who received adjunctive immunotherapy after thorough investigation and extensive conventional treatments.</div></div><div><h3>Methods</h3><div>We evaluated 45 individuals (93% female, ages 12–30 years) with atypical psychiatric presentations suggesting potential neuroimmune involvement. Participants underwent clinical phenotyping, laboratory investigation, cerebrospinal fluid (CSF) analysis, neuroimaging, and/or electroencephalography. We tracked outcomes after personalized immunotherapy through global clinical improvement (Clinical Global Impressions-Global Improvement) and changes in social-occupational functioning (Social and Occupational Functioning Assessment Scale [SOFAS]), education/employment status (not in education, employment, or training [NEET]), psychiatric hospitalization, and medication use. Treatment response was assessed post-intervention, at 6 to 12 months, and at a long-term follow-up (78.2 ± 31.3 months).</div></div><div><h3>Results</h3><div>Participants presented with severe depression (80%), psychotic features (56%), treatment resistance (82%), and/or neurological symptoms (96%). Illness duration before immunotherapy was often prolonged (mean = 4.8 ± 4.7 years, median = 3 years). Autoantibodies were detected in serum or CSF in 64% of participants, while 91% showed elevated inflammatory markers. Of 43 individuals receiving immunotherapy, 88% experienced clinical improvement posttreatment, with 79% maintaining long-term benefits. Functional outcomes improved significantly: SOFAS scores increased from 43.2 ± 11.8 to 69.2 ± 9.8, while NEET rates declined from 81% to 14%. Psychiatric hospitalization dropped from 93% to 7%, and psychotropic medication use decreased from 84% to 9%. Earlier treatment predicted better outcomes (<em>p</em> = .025). Adverse effects occurred in 79% of participants, with 21% experiencing moderate-to-severe complications.</div></div><div><h3>Conclusions</h3><div>These findings suggest the importance of early identification and specialist assessment of atypical psychiatric presentations in young people. New guidelines need to support appropriate screening, personalized management, and long-term treatment and monitoring protocols.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100564"},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Effects of Early-Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents","authors":"Elysia Poggi Davis ,&nbsp;Bianca T. Leonard ,&nbsp;Robert J. Jirsaraie ,&nbsp;David B. Keator ,&nbsp;Steven L. Small ,&nbsp;Curt A. Sandman ,&nbsp;Victoria B. Risbrough ,&nbsp;Hal S. Stern ,&nbsp;Laura M. Glynn ,&nbsp;Michael A. Yassa ,&nbsp;Tallie Z. Baram ,&nbsp;Jerod M. Rasmussen","doi":"10.1016/j.bpsgos.2025.100561","DOIUrl":"10.1016/j.bpsgos.2025.100561","url":null,"abstract":"<div><h3>Background</h3><div>Unpredictable childhood experiences are an understudied form of early-life adversity that impact neurodevelopment. The neurobiological processes by which exposure to early-life unpredictability impact development and vulnerability to psychopathology remain poorly understood. In the current study, we investigated the sex-specific consequences of early-life unpredictability on the limbic network, focusing on the hippocampus and the amygdala.</div></div><div><h3>Methods</h3><div>Participants included 150 youths (54% female). Early-life unpredictability was assessed using the Questionnaire of Unpredictability in Childhood (QUIC). Participants engaged in 1 or more task–functional magnetic resonance imaging scans between the ages of 8 and 17 (223 total observations) measuring blood oxygen level–dependent (BOLD) responses to novel and familiar scenes.</div></div><div><h3>Results</h3><div>Exposure to early-life unpredictability was associated with BOLD contrast (novel vs. familiar) in a sex-specific manner. For boys, but not girls, higher QUIC scores were associated with lower BOLD activation in response to novel versus familiar stimuli in the hippocampal head and amygdala. Secondary psychophysiological interaction analyses revealed complementary sex-specific associations between QUIC scores and condition-specific functional connectivity between the right and left amygdala, as well as between the right amygdala and hippocampus bilaterally.</div></div><div><h3>Conclusions</h3><div>Exposure to unpredictability in early life has persistent implications for the functional operations of limbic circuits. Importantly, consistent with emerging experimental animal and human studies, the consequences of early-life unpredictability differ for boys and girls. Furthermore, impacts of early-life unpredictability were independent of other risk factors including lower household income and negative life events, indicating distinct consequences of early-life unpredictability beyond more commonly studied types of early-life adversity.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100561"},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Irritability as a Potentially Causal Risk Pathway to Depression Using Two Genetically Informed Designs","authors":"Amy Shakeshaft ,&nbsp;Olakunle Oginni ,&nbsp;Joanna Martin ,&nbsp;Charlotte A. Dennison ,&nbsp;Olga Eyre ,&nbsp;Ellen Leibenluft ,&nbsp;Sebastian Lundström ,&nbsp;Evie Stergiakouli ,&nbsp;Henrik Larsson ,&nbsp;Paul Lichtenstein ,&nbsp;Argyris Stringaris ,&nbsp;Lucy Riglin ,&nbsp;Mark J. Taylor ,&nbsp;Anita Thapar","doi":"10.1016/j.bpsgos.2025.100566","DOIUrl":"10.1016/j.bpsgos.2025.100566","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) is heterogeneous, with diverse risk pathways leading to illness. Identifying causal routes to depression helps prioritize targets for early intervention and prevention strategies. Although irritability is associated with risk for later depression, this association could be explained by confounders, including genetic confounders.</div></div><div><h3>Methods</h3><div>We used two genetically informed designs to examine whether irritability is causally linked to depression. First, using data from the Child and Adolescent Twin Study in Sweden (CATSS) (<em>N</em> = 16,495) and linked Swedish National Patient Register (NPR), we assessed the relationship between irritability and MDD using the monozygotic twin differences design, which controls for genetic influences. Irritability was assessed at age 15 using the Strengths and Difficulties Questionnaire. MDD diagnoses were identified from ages 15 to 25 years using the NPR. Second, we conducted bidirectional two-sample Mendelian randomization (MR) to examine relationships between genetic liability to self-reported irritability and depression, using published genome-wide association studies.</div></div><div><h3>Results</h3><div>In CATSS, associations were observed between irritability at age 15 (parent-reported odds ratio [OR] = 1.93 [1.61–2.34], <em>p</em> = 4.65 × 10⁻¹²; self-reported OR = 1.62 [1.36–1.93], <em>p</em> = 7.13 × 10⁻⁸) and NPR-recorded MDD diagnoses from 15 to 25 years. Monozygotic twin analysis revealed an association between self-reported twin differences in irritability and MDD discordance (OR = 1.57 [1.04–2.36], <em>p</em> = .032). Results were inconclusive for parent-reported irritability (OR = 1.20 [0.73–1.96], <em>p</em> = .47). MR revealed a bidirectional relationship (irritability to depression inverse-variance weighted [IVW] OR = 3.31 [2.07–5.28], <em>p</em> = 5.5 × 10⁻⁷; depression to irritability IVW OR = 1.07 [1.05–1.10], <em>p</em> = 3.2 × 10⁻¹¹).</div></div><div><h3>Conclusions</h3><div>These results indicate that self-reported irritability may represent a causal risk pathway to MDD and thus could serve as a potential target for MDD prevention or early intervention.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100566"},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Preterm Birth With Autism Spectrum Disorder.","authors":"Basant K Puri","doi":"10.1016/j.bpsgos.2025.100559","DOIUrl":"10.1016/j.bpsgos.2025.100559","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"100559"},"PeriodicalIF":3.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-Life Adversities and Epigenetic Modifications: The Impact on Brain Development, Synaptic Function, and Stress Response","authors":"Gianluca Serafini ,&nbsp;Riccardo Guglielmo ,&nbsp;Andrea Escelsior ,&nbsp;Andrea Amerio ,&nbsp;Andrea Aguglia ,&nbsp;Mario Amore","doi":"10.1016/j.bpsgos.2025.100560","DOIUrl":"10.1016/j.bpsgos.2025.100560","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100560"},"PeriodicalIF":3.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2667-1743(25)00108-9","DOIUrl":"10.1016/S2667-1743(25)00108-9","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100554"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S2667-1743(25)00109-0","DOIUrl":"10.1016/S2667-1743(25)00109-0","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100555"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2667-1743(25)00111-9","DOIUrl":"10.1016/S2667-1743(25)00111-9","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100557"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}