Biological psychiatry global open science最新文献

{"title":"Functional Brain Activity Associated With Intermittent Rhythmic Delta/Theta Activity: A Transdiagnostic Electroencephalography–Functional Magnetic Resonance Imaging Resting-State Study","authors":"Bernd Feige ,&nbsp;Katharina von Zedtwitz ,&nbsp;Isabelle Matteit ,&nbsp;Andrea Schlump ,&nbsp;Volker A. Coenen ,&nbsp;Kathrin Nickel ,&nbsp;Kimon Runge ,&nbsp;Harald Prüss ,&nbsp;Alexander Rau ,&nbsp;Marco Reisert ,&nbsp;Swantje Matthies ,&nbsp;Katharina Domschke ,&nbsp;Simon J. Maier ,&nbsp;Ludger Tebartz van Elst ,&nbsp;Dominique Endres","doi":"10.1016/j.bpsgos.2025.100661","DOIUrl":"10.1016/j.bpsgos.2025.100661","url":null,"abstract":"<div><h3>Background</h3><div>Intermittent rhythmic delta/theta activity (IRDA/IRTA) detected via electroencephalography (EEG) has been implicated in the pathophysiology of neuropsychiatric illnesses. Therefore, a combined EEG and functional magnetic resonance imaging (fMRI) approach was applied in a transdiagnostic group of patients with different causalities, i.e., autoimmune-mediated (in suspected autoimmune psychiatric syndromes [APS]) and primary psychiatric (borderline personality disorder [BPD]) causalities, as well as in healthy control (HC) participants, to characterize the brain regions functionally correlated with IRDA/IRTA.</div></div><div><h3>Methods</h3><div>Overall, 135 EEG-fMRI datasets met the quality criteria, including 33 patients with suspected APS, 59 cases with BPD, and 43 HC participants. fMRI data were obtained using ultrafast MR encephalography and analyzed using AFNI. IRDA/IRTA events were separated from artifacts using independent component analysis and detected algorithmically. Brain regions (clusters) significantly correlated with IRDA/IRTA were first determined in all participants. Clusters occurring across all groups were classified as consensus areas. The groups were also analyzed individually, adding disease- or disorder-specific clusters not overlapping with the consensus areas.</div></div><div><h3>Results</h3><div>Eleven consensus areas were identified across the 3 groups: 5 of them showed increased activity (Brodmann area [BA] 43-right [r], BA 2-left [l], BA 4-r, BA 18-r, BA 26/29/30-r), and 6 had reduced activity (BA 39-l, BA 10-l, BA 23-l, BA 19-l, BA 10-r, BA 18-l). The APS group showed 5 additional clusters, all with reduced activity (BAs 39-r, 1/3-r, 8-r, 4-l, 21-r). The BPD group showed one further cluster with increased activity (BA 17-l).</div></div><div><h3>Conclusions</h3><div>In this study, IRDA/IRTA-related brain activity changes across the groups were identified, with excitatory brain activity especially in fronto-centro-temporal brain areas with similarities to the salience network. Additional disease- or disorder-specific changes were discovered in APS and BPD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100661"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Alterations of Brain and Behavior in Children With Low Prenatal Alcohol Exposure","authors":"Xiangyu Long ,&nbsp;Catherine Lebel","doi":"10.1016/j.bpsgos.2025.100648","DOIUrl":"10.1016/j.bpsgos.2025.100648","url":null,"abstract":"<div><h3>Background</h3><div>Heavy prenatal alcohol exposure (PAE) is associated with alterations in behavior and cognitive and brain development. However, the effects of low levels of PAE on the brain and behavior remain unclear. In the current study, we aimed to investigate longitudinal changes in the brain and behavior in children with low levels of PAE compared with well-matched unexposed children.</div></div><div><h3>Methods</h3><div>Children (<em>n</em> = 108, mean [SD] = 9.52 [0.50] years at baseline) with PAE (0.97 ± 0.90 drinks/wk) and control children (<em>n</em> = 108, 9.52 [0.50] years at baseline) matched on socioeconomic status were selected from the ABCD (Adolescent Brain Cognitive Development) Study and were followed over 4 years with magnetic resonance imaging and Child Behavior Checklist (CBCL) scores. No children had adverse exposures to other substances.</div></div><div><h3>Results</h3><div>Compared with unexposed children, children with low levels of PAE had persistently higher CBCL scores (worse behavior) and higher intracranial volumes over time.</div></div><div><h3>Conclusions</h3><div>Our results provide further evidence of alterations in the brain and behavior associated with low levels of PAE across early adolescence, highlighting the importance of prevention and early intervention even with low levels of PAE.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100648"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity","authors":"Jessica P.Y. Hua ,&nbsp;Brian J. Roach ,&nbsp;Holly K. Hamilton ,&nbsp;Peter M. Bachman ,&nbsp;Aysenil Belger ,&nbsp;Ricardo E. Carrión ,&nbsp;Erica Duncan ,&nbsp;Jason K. Johannesen ,&nbsp;Gregory A. Light ,&nbsp;Margaret Niznikiewicz ,&nbsp;Jean Addington ,&nbsp;Carrie E. Bearden ,&nbsp;Kristin S. Cadenhead ,&nbsp;Diana O. Perkins ,&nbsp;William S. Stone ,&nbsp;Elaine F. Walker ,&nbsp;Scott W. Woods ,&nbsp;Tyrone D. Cannon ,&nbsp;Daniel H. Mathalon","doi":"10.1016/j.bpsgos.2025.100664","DOIUrl":"10.1016/j.bpsgos.2025.100664","url":null,"abstract":"<div><h3>Background</h3><div>Reduced mismatch negativity (MMN) is a widely replicated schizophrenia biomarker. Time-frequency analyses suggest that deficient phase synchrony and/or power of electroencephalography (EEG) event-related oscillations, especially theta, contribute to MMN deficits in schizophrenia. Whether theta oscillations assessed from a passive auditory oddball paradigm are abnormal in clinical high-risk for psychosis (CHR-P) individuals and whether these oscillations predict CHR-P clinical outcomes remain unclear. These questions were addressed using data from NAPLS2 (North American Prodrome Longitudinal Study 2).</div></div><div><h3>Methods</h3><div>EEG was recorded from 77 CHR-P individuals who converted to psychosis (CHR-Cs), 238 CHR-P nonconverters (CHR-NCs) who completed a 24-month follow-up, and 241 healthy control (HC) individuals. Theta oscillations elicited by standard and deviant tones were calculated. Theta (4–6 Hz) intertrial phase coherence (ITC) and total power were compared between groups and evaluated as predictors of time to psychosis conversion in the full CHR-P sample. Furthermore, analyses of covariance were used to assess whether theta deficits persisted while covarying for MMN.</div></div><div><h3>Results</h3><div>The CHR-C group, relative to the HC and CHR-NC groups, had reduced theta ITC for standards and deviants (<em>p</em>s &lt; .029) and reduced total power for standards and deviants relative to the HC group (<em>p</em> = .021). Reduced theta ITC for standards and deviants predicted earlier psychosis conversion. The previously reported deficit in MMN amplitude in the CHR-C group was no longer significant after accounting for theta ITC or total power averaged across stimuli (<em>p</em>s &gt; .187), but this was not true for theta ITC or total power deviant-standard difference scores (<em>p</em>s &lt; .039).</div></div><div><h3>Conclusions</h3><div>These results implicate abnormalities in microcircuit generators of theta oscillations in CHR-P individuals at highest risk.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100664"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Window of Opportunity: Unraveling How Puberty Relates to Psychotic-Like Experiences During Adolescence","authors":"Mark Curtis","doi":"10.1016/j.bpsgos.2025.100687","DOIUrl":"10.1016/j.bpsgos.2025.100687","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100687"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Occipital-Fronto-Limbic Circuit of Body Dysmorphic Disorder: A Systematic Review and Meta-Analysis of Neuroimaging Studies","authors":"Yihui Cheng ,&nbsp;Emalee Burrows ,&nbsp;Ludvic Zrinzo ,&nbsp;Harith Akram ,&nbsp;Trevor W. Robbins ,&nbsp;Himanshu Tyagi","doi":"10.1016/j.bpsgos.2025.100676","DOIUrl":"10.1016/j.bpsgos.2025.100676","url":null,"abstract":"<div><h3>Background</h3><div>Body dysmorphic disorder (BDD) is a severe psychiatric disorder characterized by excessive preoccupation with perceived flaws in appearance. In this review, we aim to synthesize the latest findings on the neurobiology of BDD and propose an updated BDD neurocircuitry model.</div></div><div><h3>Methods</h3><div>A systematic search identified 38 peer-reviewed original articles, and the protocol was registered (<span><span>CRD42024553665</span><svg><path></path></svg></span>). Qualitative thematic analysis was conducted, and activation likelihood estimation (ALE) meta-analysis was performed to quantify brain activation patterns.</div></div><div><h3>Results</h3><div>Brain regions with significant morphometric divergence in patients with BDD were predominantly located in primary and secondary visual processing areas and temporal-limbic and frontal-striatal networks despite overall heterogeneous findings. The electroencephalography studies suggested early visual processing and attentional abnormalities. The ALE analysis revealed a general hyperactivation over the frontotemporal region and hypoactivation over parieto-occipital regions. Although BDD shared similar connectivity patterns in frontostriatal and arbitration networks with obsessive-compulsive disorder, it was further characterized by bottom-up and top-down interaction between the ventral visual stream and temporal-limbic network compared with anorexia nervosa. Neurotransmitters such as serotonin, dopamine, and oxytocin play a key role in the pathophysiology of BDD, suggesting a complex interplay of neural circuits and neurotransmitters underlying the disorder.</div></div><div><h3>Conclusions</h3><div>This comprehensive review of up-to-date neurobiological studies of individuals with BDD reveals differences in brain structure and functionality compared with control participants. The proposed neurocircuitry model expands on the previous understanding of BDD neurobiology and elucidates the interconnection between the visual processing, temporal-limbic, and frontostriatal networks and their clinical implications. This review provides theoretical support for future neuromodulation target identification.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100676"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"μ Opioid Modulation of Sensorimotor Functional Connectivity in Autism: Insights From a Pharmacological Neuroimaging Investigation Using Tianeptine","authors":"Mihail Dimitrov ,&nbsp;Nichol M.L. Wong ,&nbsp;Sydney Leaman ,&nbsp;Lucas G.S. França ,&nbsp;Ioannis Valasakis ,&nbsp;Jason He ,&nbsp;David J. Lythgoe ,&nbsp;James L. Findon ,&nbsp;Robert H. Wichers ,&nbsp;Vladimira Stoencheva ,&nbsp;Dene M. Robertson ,&nbsp;Sarah Blainey ,&nbsp;Glynis Ivin ,&nbsp;Štefan Holiga ,&nbsp;Mark D. Tricklebank ,&nbsp;Dafnis Batalle ,&nbsp;Declan G.M. Murphy ,&nbsp;Gráinne M. McAlonan ,&nbsp;Eileen Daly","doi":"10.1016/j.bpsgos.2025.100663","DOIUrl":"10.1016/j.bpsgos.2025.100663","url":null,"abstract":"<div><h3>Background</h3><div>Reproducible patterns of atypical functional connectivity (FC) of sensorimotor and higher-order networks have previously been identified in the autistic brain. However, the neurosignaling pathways underpinning these differences remain unclear. The μ opioid system is involved in sensory processing as well as social and reward behaviors and has been implicated in autism, suggesting a potential role in shaping the autistic brain. Therefore, we tested the hypothesis that there is atypical involvement of the μ opioid system in these networks in autism.</div></div><div><h3>Methods</h3><div>We used a placebo-controlled, double-blind, randomized, crossover study design to compare the effects of a single dose of the μ opioid receptor agonist tianeptine in autistic (<em>n</em> = 20) and nonautistic (<em>n</em> = 21) males on FC of sensorimotor and frontoparietal networks.</div></div><div><h3>Results</h3><div>We found that tianeptine increased FC of a sensorimotor network previously characterized by atypically low FC in autism. The connectivity of the frontoparietal network was not significantly shifted.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that μ opioid neurosignaling may contribute to functional brain differences in the sensorimotor network in autism. Given that sensorimotor system alterations are thought to be central to autism and contribute to other core autistic features, as well as adaptability and mental health, further research is warranted to explore the translational potential of μ opioid modulation in autism.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100663"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parsing Socioeconomic Effects on Treatment Trajectory and Reward Processing in Depression","authors":"Kristina T. Legget","doi":"10.1016/j.bpsgos.2025.100686","DOIUrl":"10.1016/j.bpsgos.2025.100686","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100686"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral and Prefrontal Circuit Deficits in a Newly Developed Setbp1 Haploinsufficiency Mouse Model","authors":"MacKenzie A. Howard,&nbsp;Mendee A. Geist,&nbsp;Gregory J. Ordemann,&nbsp;Alena Kizimenko,&nbsp;Dominic M. Balice,&nbsp;F. Isaac Guillén,&nbsp;Emmanuella Bassey,&nbsp;Polina Lyuboslavsky,&nbsp;Audrey C. Brumback","doi":"10.1016/j.bpsgos.2025.100666","DOIUrl":"10.1016/j.bpsgos.2025.100666","url":null,"abstract":"<div><h3>Background</h3><div>SET binding protein 1 (<em>SETBP1</em>) regulates the cell cycle, gene transcription, and other vital intracellular processes. <em>SETBP1</em> loss-of-function variants cause the neurodevelopmental disorders <em>SETBP1</em>-haploinsufficiency disorder and <em>SETBP1</em>-related disorders (<em>SETBP1</em>-HD and <em>SETBP1</em>-RD), which are characterized by attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), intellectual disability/developmental delay, and other neurological disabilities. Here we sought to characterize behavioral, physiological, and cell morphology phenotypes of a newly developed mouse model of <em>SETBP1</em>-HD.</div></div><div><h3>Methods</h3><div>We used open field, 3-chamber, and Y-maze behavioral tests to measure activity, social interest, and spatial learning, respectively. We used whole-cell current clamp recordings from medial prefrontal cortex (mPFC) layer-5 extratelencephalic projection neurons in ex vivo slices to measure cell intrinsic and spike properties. We used morphological reconstruction to measure dendritic arborization in recorded neurons.</div></div><div><h3>Results</h3><div><em>Setbp1</em>^{<em>+/−</em>} mice exhibited hyperactivity, decreased social interest, and increased olfactory exploration in behavioral tests. Ex vivo electrophysiology revealed hypoexcitability in layer-5 extratelencephalic projection neurons in the mPFC. Morphological reconstruction revealed changes to the way branch points and length are distributed within the apical dendritic arbor of these prefrontal pyramidal neurons without changes in overall length or branch number.</div></div><div><h3>Conclusions</h3><div>These data show that <em>Setbp1</em>^{<em>+/−</em>} mice exhibit phenotypes parallel to the ADHD and ASD that are common in patients with <em>SETBP1</em>-HD. Additionally, we identified cellular changes to a key control center for attention, social behavior, and cognitive function that may elucidate the mechanism that underlies the neuropsychiatric disabilities of this disorder.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100666"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolism and the Mind: Investigating the Link Between Glucose Control and Reinforcement Learning in Humans","authors":"Hugo Fleming ,&nbsp;Martyna K. Stasiak ,&nbsp;Isabel Lau ,&nbsp;Annalise Whines ,&nbsp;Sara Z. Mehrhof ,&nbsp;Camilla L. Nord","doi":"10.1016/j.bpsgos.2025.100645","DOIUrl":"10.1016/j.bpsgos.2025.100645","url":null,"abstract":"<div><h3>Background</h3><div>Signals from the body profoundly influence cognition. This process is known as interoception, and has been extensively studied in the cardiac, respiratory, and gastric domains; in contrast, metabolic influences remain poorly understood. Here, we focus on the link between glucose control and cognition, motivated by the observation that there is substantial, unexplained comorbidity between type 2 diabetes and depression. In rodents, insulin modulates dopamine signaling in the ventral striatum. We therefore hypothesized that, in humans, differences in glucose control would be associated with altered reward learning.</div></div><div><h3>Methods</h3><div>To test this hypothesis, we recruited 48 participants from the general population, who each completed a glucose tolerance test, a monetary reward learning task known to relate to dopamine function, and mental health questionnaires. We fitted an established reinforcement learning model to the task data to obtain computational parameters characterizing participants’ learning, and then examined the associations between these parameters and their glucose control.</div></div><div><h3>Results</h3><div>We discovered that poorer glucose control was associated with greater reliance on recent rewards during learning, which was in turn associated with higher levels of depression symptoms. There was also more modest evidence for the association between glucose control and depression symptoms.</div></div><div><h3>Conclusions</h3><div>Together, our results identify a specific neurocognitive process, reward learning, by which metabolic information may influence cognition, and which may explain the link between metabolic diseases such as type 2 diabetes and depression.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100645"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145798675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2667-1743(26)00014-5","DOIUrl":"10.1016/S2667-1743(26)00014-5","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100701"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}