Biological psychiatry global open science最新文献

{"title":"Diminished Social Memory and Hippocampal Correlates of Social Interactions in Chronic Social Defeat Stress Susceptibility","authors":"Amanda Larosa ,&nbsp;Tian Rui Zhang ,&nbsp;Alice S. Wong ,&nbsp;Cyrus Y.H. Fung ,&nbsp;Xiong Ling Yun (Jenny) Long ,&nbsp;Prabhjeet Singh ,&nbsp;Benjamin C.M. Fung ,&nbsp;Tak Pan Wong","doi":"10.1016/j.bpsgos.2025.100455","DOIUrl":"10.1016/j.bpsgos.2025.100455","url":null,"abstract":"<div><h3>Background</h3><div>Susceptibility to chronic stress has been associated with depression, a mood disorder that highly implicates the hippocampus. Hippocampal contribution to stress susceptibility has been supported by findings in mice following chronic social defeat stress (CSDS). However, little is known about the role of hippocampal activity in determining the development of stress susceptibility.</div></div><div><h3>Methods</h3><div>We used the UCLA Miniscope to longitudinally measure the activity of dorsal CA1 hippocampal neurons during CSDS. In addition to examining the representation of social information by these neurons, we compared social memory in mice that were either susceptible or resilient to CSDS.</div></div><div><h3>Results</h3><div>We observed more stable dorsal CA1 correlates of social interaction and social memory in CSDS-resilient mice. Such changes were absent in CSDS-susceptible mice and accompanied by greater social memory impairments.</div></div><div><h3>Conclusions</h3><div>CSDS susceptibility may be supported by hippocampal social cognitive processes, as reflected in diminished hippocampal representations of social information and greater impairment in social memory in suspectible compared with resilient mice.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100455"},"PeriodicalIF":4.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Microbiome in Relation to Mental Distress Across Two Points During Pregnancy: Data From U.S. and Swedish Cohorts","authors":"Mary Kimmel ,&nbsp;Bangzhuo Tong ,&nbsp;Alfons Edbom Devall ,&nbsp;Richelle D. Björvang ,&nbsp;Ina Schuppe-Koistinen ,&nbsp;Lars Engstrand ,&nbsp;Emma Fransson ,&nbsp;Alkistis Skalkidou ,&nbsp;Luisa W. Hugerth","doi":"10.1016/j.bpsgos.2025.100453","DOIUrl":"10.1016/j.bpsgos.2025.100453","url":null,"abstract":"<div><h3>Background</h3><div>In this study, we aimed to characterize the gut microbiome and its potential functioning in 2 populations at 2 time points during pregnancy in relation to mental distress.</div></div><div><h3>Methods</h3><div>During the second and third trimester, individuals from the United States and Sweden completed the Edinburgh Postnatal Depression Scale and provided fecal samples for whole-genome metagenomics. A total of 832 and 161 samples were sequenced and analyzed from the Swedish cohort and the U.S. cohort, respectively. Multiple characterizations of the microbial community were analyzed in relation to distress measured using the Edinburgh Postnatal Depression Scale. Principal coordinate analysis and distance-based redundancy analysis assessed variation in functional gut-brain modules. For the U.S. cohort, the Trier Social Stress Test was administered 8 weeks postpartum while collecting salivary cortisol.</div></div><div><h3>Results</h3><div>Principal coordinate analysis identified 4 sample clusters based on the gut-brain modules distinguished by functions such as short-chain fatty acid synthesis and cortisol degradation. While with distance-based redundancy analysis, mental distress subtypes did not significantly contribute to variation in gut-brain modules (<em>p</em> = .085 for Sweden, <em>p</em> = .23 for the U.S.), a U.S. sample cluster distinguished by lower cortisol degradation from another cluster with higher gut microbial cortisol degradation abundance had significantly higher odds of being associated with depression (<em>p</em> = .024). The U.S. sample cluster with lower gut microbial cortisol degradation abundance also had significantly higher cortisol levels after a postpartum social stressor.</div></div><div><h3>Conclusions</h3><div>Further studies are warranted to investigate the potential for the gut microbiome to serve as biomarkers of gut-brain axis health during pregnancy across disparate populations.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100453"},"PeriodicalIF":4.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prepartal Stress, Prepartal and Postpartal Hair Glucocorticoid Concentrations, and Symptoms of Postpartum Depression 3 Days and 12 Weeks After Delivery","authors":"Dena Sadeghi-Bahmani ,&nbsp;Serge Brand ,&nbsp;Gunther Meinlschmidt ,&nbsp;Marion Tegethoff ,&nbsp;Jennifer Kurath ,&nbsp;Nicole Bürki ,&nbsp;Irene Hösli ,&nbsp;Thorsten Mikoteit","doi":"10.1016/j.bpsgos.2025.100454","DOIUrl":"10.1016/j.bpsgos.2025.100454","url":null,"abstract":"<div><h3>Background</h3><div>Postpartum depression (PPD) is a serious mental health problem that affects about 17% of mothers. The aims of the current study were to observe the associations between prenatal stress, self- and expert-rated PPD, and prepartal and postpartal hair cortisol and cortisone concentrations as proxies for altered hypothalamic-pituitary-adrenal axis activity (HPA-AA).</div></div><div><h3>Methods</h3><div>A total of 129 mothers (mean age 33.1 years) completed the Edinburgh Postnatal Depression Scale 3 days (baseline) and 12 weeks (study end) postpartum. At the end of the study, participants reported on prepartum stressful life events, experts rated participants’ symptoms of depression, and participants provided 6 cm of hair strands for analysis of hair glucosteroid levels 12 weeks before and 12 weeks after delivery.</div></div><div><h3>Results</h3><div>Prepartal stress was associated with higher scores for self- and expert-rated PPD and with lower hair cortisone concentrations as a proxy for less adaptive HPA-AA. Higher prepartal and postpartal hair cortisol/cortisone ratios (i.e., higher cortisol/lower cortisone concentrations) were associated with higher PPD symptom scores.</div></div><div><h3>Conclusions</h3><div>Women with prepartal stress were at increased risk of experiencing PPD 12 weeks after delivery. Altered hair steroid levels (lower cortisone concentrations) as a proxy for altered HPA-AA further substantiated this association. Results suggest that 1) both prepartal stress and the suppression of HPA-AA appear to be involved in the development of PPD; 2) hair steroid analysis can be used to predict PPD; and 3) women with prepartal stressful life events may benefit from timely support and relief to decrease their risk of developing PPD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100454"},"PeriodicalIF":4.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Hidden Mark of a Troubled Past: Neuroimaging and Transcriptomic Analyses Reveal Interactive Effects of Maternal Immune Activation and Adolescent THC Exposure Suggestive of Increased Neuropsychiatric Risk","authors":"Mario Moreno-Fernández ,&nbsp;Víctor Luján ,&nbsp;Shishir Baliyan ,&nbsp;Celia Poza ,&nbsp;Roberto Capellán ,&nbsp;Natalia de las Heras-Martínez ,&nbsp;Miguel Ángel Morcillo ,&nbsp;Marta Oteo ,&nbsp;Emilio Ambrosio ,&nbsp;Marcos Ucha ,&nbsp;Alejandro Higuera-Matas","doi":"10.1016/j.bpsgos.2025.100452","DOIUrl":"10.1016/j.bpsgos.2025.100452","url":null,"abstract":"<div><h3>Background</h3><div>Maternal exposure to infections during gestation has been shown to predispose individuals to neuropsychiatric disorders. Additionally, clinical data suggest that cannabis use may trigger the onset of schizophrenia in vulnerable individuals. However, the direction of causality remains unclear.</div></div><div><h3>Methods</h3><div>To elucidate this issue, we utilized a rat model of maternal immune activation combined with exposure to increasing doses of Δ⁹-tetrahydrocannabinol during adolescence in both male and female rats. We investigated several behaviors in adulthood relevant for neuropsychiatric disorders, including impairments in working memory, deficits in sensorimotor gating, alterations in social behavior, anhedonia, and potential changes in implicit learning (conditioned taste aversion). Furthermore, we conducted a longitudinal positron emission tomography study to target affected brain regions and, subsequently, collected brain samples of one such region (the orbitofrontal cortex) for RNA sequencing analyses, which were also performed on peripheral blood mononuclear cells to identify peripheral biomarkers.</div></div><div><h3>Results</h3><div>While adolescent Δ⁹-tetrahydrocannabinol did not unmask latent behavioral disruptions, positron emission tomography scans revealed several brain alterations dependent on the combination of both hits. Additionally, the transcriptomic studies demonstrated that maternal immune activation affected dopaminergic, glutamatergic, and serotoninergic genes, with the combination of both exposures in most cases shifting the expression from downregulation to upregulation. In peripheral cells, interactive effects were observed on inflammatory pathways, and some genes were proposed as biomarkers.</div></div><div><h3>Conclusions</h3><div>These results suggest that the combination of these 2 vulnerability factors leaves a lasting mark on the body, potentially predisposing individuals to neuropsychiatric disorders even before behavioral alterations manifest.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100452"},"PeriodicalIF":4.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats","authors":"Kaitlyn LaRocco ,&nbsp;Peroushini Villiamma ,&nbsp;Justin Hill ,&nbsp;Mara A. Russell ,&nbsp;Ralph J. DiLeone ,&nbsp;Stephanie M. Groman","doi":"10.1016/j.bpsgos.2025.100450","DOIUrl":"10.1016/j.bpsgos.2025.100450","url":null,"abstract":"<div><h3>Background</h3><div>Problematic opioid use that emerges in a subset of individuals may be due to preexisting disruptions in the biobehavioral mechanisms that regulate drug use. The identity of these mechanisms is not known, but emerging evidence suggests that suboptimal decision making that is observable prior to drug use may contribute to the pathology of addiction.</div></div><div><h3>Methods</h3><div>The current study investigated the relationship between decision-making phenotypes and opioid-taking behaviors in male and female Long Evans rats. Adaptive decision-making processes were assessed using a probabilistic reversal learning task and oxycodone- (or vehicle, as a control) taking behaviors assessed daily in 32 sessions using a saccharin fading procedure that promoted dynamic intake of oxycodone. Tests of motivation, extinction, and reinstatement were also performed.</div></div><div><h3>Results</h3><div>Computational analyses of decision-making data identified data-driven metrics that predicted self-administration of oxycodone and addiction-relevant behaviors. Moreover, preexisting impairments in reward-guided decision making observed in female rats were associated with greater addiction-relevant behaviors when compared with males.</div></div><div><h3>Conclusions</h3><div>These results provide new insights into the biobehavioral mechanisms that regulate opiate-taking behaviors and offer a novel phenotypic approach for interrogating sex differences in addiction susceptibility and opioid use disorders.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100450"},"PeriodicalIF":4.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Transcriptomic Signature of Depressive Symptoms in Late Life","authors":"Stuart Matan-Lithwick ,&nbsp;Melissa C. Misztal ,&nbsp;Mu Yang ,&nbsp;Thomas DeLong ,&nbsp;Shreejoy Tripathy ,&nbsp;Jeffrey T. Dunn ,&nbsp;David A. Bennett ,&nbsp;Philip L. De Jager ,&nbsp;Yanling Wang ,&nbsp;Daniel W. Fisher ,&nbsp;Hongxin Dong ,&nbsp;Daniel Felsky","doi":"10.1016/j.bpsgos.2025.100448","DOIUrl":"10.1016/j.bpsgos.2025.100448","url":null,"abstract":"<div><h3>Background</h3><div>Depressive symptoms in late life can impair daily function and accompany cognitive decline. However, the molecular mechanisms that underlie these changes in the brain remain poorly understood.</div></div><div><h3>Methods</h3><div>Differential expression analysis was performed on bulk-tissue RNA sequencing data generated from dorsolateral prefrontal cortex samples of elderly participants in ROS/MAP (Religious Orders Study and Memory and Aging Project; <em>N</em> = 998, mean age at death = 89.7 years). Bulk tissue RNA sequencing was analyzed against depressive symptoms measured prior to death, controlling for Alzheimer’s disease neuropathology, medication status, and lifestyle factors. Sex-stratified models were also tested.</div></div><div><h3>Results</h3><div>Increased abundance of the Prader-Willi syndrome–associated gene <em>PWAR1</em> (corrected <em>p</em> = 5.47 × 10⁻³) and <em>CTDSPL2</em> (corrected <em>p</em> = .03) were associated with a higher burden of depressive symptoms in the combined sample. An additional 14 genes showed suggestive associations, including several with known links to neuropsychiatric illness (e.g., <em>ACVR2B-AS1</em>, <em>COL19A1</em>). Functional enrichment analysis revealed downregulation of aerobic metabolism and upregulation of both amino acid catabolism and DNA modification processes. Differential expression signatures were poorly correlated between males and females (Pearson <em>r</em> = 0.12; 95% CI, 0.10 to 0.13), and only the male group showed independently significant differential expression. Little overlap was found with previously published analyses of major depressive disorder.</div></div><div><h3>Conclusions</h3><div>Building on recently published single-nucleus profiling, we present the largest-ever study of transcriptomic correlates of depressive symptoms in late life, revealing new insights into sex-specific regulators. <em>PWAR1</em> and <em>CTDSPL2</em> were identified as putative markers of late-life depression in the dorsolateral prefrontal cortex and warrant further study.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100448"},"PeriodicalIF":4.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmenting Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder With Transcranial Infrared Laser Stimulation","authors":"Douglas W. Barrett,&nbsp;Christopher G. Beevers,&nbsp;F. Gonzalez-Lima","doi":"10.1016/j.bpsgos.2025.100449","DOIUrl":"10.1016/j.bpsgos.2025.100449","url":null,"abstract":"<div><h3>Background</h3><div>Transcranial infrared laser stimulation (TILS) is a noninvasive form of photobiomodulation that facilitates prefrontal energy metabolism and oxygenation, resulting in cognitive-enhancing effects. Cognitive behavioral therapy is a mainstream treatment for major depressive disorder. This is the first study to investigate whether TILS would augment the antidepressant effects of internet-based cognitive behavioral therapy.</div></div><div><h3>Methods</h3><div>Sixty participants with major depressive disorder were given access to Deprexis, a form of internet-based cognitive behavioral therapy, for 12 weeks. After the first 2 weeks, the 40 participants who had improved at least 10% in depressive symptoms from baseline as measured by the Quick Inventory of Depressive Symptomatology–Self-Report were randomly assigned to Deprexis in combination with TILS or sham/placebo. There were no significant group differences in demographics or initial depression data.</div></div><div><h3>Results</h3><div>There was a 43% reduction in Quick Inventory of Depressive Symptomatology–Self-Report scores in the sham group from the initial score to the week 12 score, while adding TILS as an adjunct therapy resulted in a reduction of 56%. Therefore, TILS resulted in an additional 30% reduction in Quick Inventory of Depressive Symptomatology–Self-Report scores ([56−43]/43 = 30%). Participants who received TILS to the right forehead once a week for 4 weeks showed a significantly greater reduction of depressive symptoms than participants who received sham/placebo. Participants reported no adverse effects.</div></div><div><h3>Conclusions</h3><div>While Deprexis alone significantly reduced depression scores in the placebo control group, this beneficial effect was augmented with the addition of TILS as an adjunct therapy. Additional research that pairs neuroenhancement methods such as TILS with cognitive interventions may reveal the potential to improve treatment outcomes in depression and other psychiatric disorders.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100449"},"PeriodicalIF":4.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-Scale Electroencephalography Patterns of Sleep and Wake in Schizophrenia","authors":"Alena Damborská","doi":"10.1016/j.bpsgos.2024.100428","DOIUrl":"10.1016/j.bpsgos.2024.100428","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100428"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GABA/Glutamate Neuron Differentiation Imbalance and Increased AKT/mTOR Signaling in CNTNAP2−/− Cerebral Organoids","authors":"Kleanthi Chalkiadaki ,&nbsp;Elpida Statoulla ,&nbsp;Maria Zafeiri ,&nbsp;Georgia Voudouri ,&nbsp;Theoklitos Amvrosiadis ,&nbsp;Alexandra Typou ,&nbsp;Niki Theodoridou ,&nbsp;Dimitrios Moschovas ,&nbsp;Apostolos Avgeropoulos ,&nbsp;Martina Samiotaki ,&nbsp;John O. Mason ,&nbsp;Christos G. Gkogkas","doi":"10.1016/j.bpsgos.2024.100413","DOIUrl":"10.1016/j.bpsgos.2024.100413","url":null,"abstract":"<div><h3>Background</h3><div>The polygenic nature of autism spectrum disorder (ASD) requires the identification of converging genetic pathways during early development to elucidate its complexity and varied manifestations.</div></div><div><h3>Methods</h3><div>We developed a human cerebral organoid model from induced pluripotent stem cells with targeted genome editing to abolish protein expression of the <em>CNTNAP2</em> ASD risk gene.</div></div><div><h3>Results</h3><div>CNTNAP2^−/− cerebral organoids displayed accelerated cell cycle, ventricular zone disorganization, and increased cortical folding. Proteomic analysis revealed disruptions in glutamatergic/GABAergic (gamma-aminobutyric acidergic) synaptic pathways and neurodevelopment, and transcriptomic analysis revealed differentially expressed genes belonging to inhibitory neuron–related gene networks. Interestingly, there was a weak correlation between the 2 datasets, suggesting nuanced translational control mechanisms. Along these lines, we found upregulated AKT/mTOR (mechanistic target of rapamycin) signaling in CNTNAP2^−/− organoids. Spatial transcriptomic analysis of CNTNAP2^−/− ventricular-like zones demonstrated pervasive changes in gene expression, implicating upregulation of cell cycle regulation, synaptic, and glutamatergic/GABAergic pathways. We noted significant overlap of all day-30 organoid omics datasets differentially expressed genes from idiopathic ASD (macrocephaly) induced pluripotent stem cell–derived telencephalic organoids, where FOXG1 was upregulated. Moreover, we detected increased GAD1-expressing and decreased TBR1-expressing cells, suggesting altered GABAergic/glutamatergic neuron development.</div></div><div><h3>Conclusions</h3><div>These findings potentially highlight a shared mechanism in the early cortical development of various forms of ASD, further elucidate the role of CNTNAP2 in ASD pathophysiology and cortical development, and pave the way for targeted therapies that use cerebral organoids as preclinical models.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100413"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2667-1743(24)00155-1","DOIUrl":"10.1016/S2667-1743(24)00155-1","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100442"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}