Biological psychiatry global open science最新文献

{"title":"Longitudinal Relationship of Early Postnatal Testosterone and Harsh Parenting at 1–3 Months of Age to Physical Aggression at 12 Months of Age in Boys and Girls","authors":"Karson T.F. Kung,&nbsp;Rachel L.C. Li,&nbsp;Eddy C.H. Tam,&nbsp;Sixuan Zhang,&nbsp;Marshall M.C. Hui","doi":"10.1016/j.bpsgos.2025.100579","DOIUrl":"10.1016/j.bpsgos.2025.100579","url":null,"abstract":"<div><h3>Background</h3><div>It has been postulated that the early postnatal period, 1 to 3 months of age, is a critical period when early androgen exposure exerts long-lasting influences on aspects of behavioral development that show sex differences. The present study conducted the first test of the relationship between testosterone concentrations at 1 to 3 months of age and subsequent physical aggression. The present study is also the first to examine early postnatal testosterone and harsh parenting simultaneously as predictors of subsequent physical aggression.</div></div><div><h3>Methods</h3><div>The longitudinal sample included 217 boys and 208 girls and their parents. When children were 1 to 3 months old, 3 weekly saliva samples were collected from each child for testosterone assays, and a parent-reported measure was used to assess harsh parenting. When children were 12 months old, parents and children were invited to take part in a follow-up where each child’s physical aggression was assessed using both an observational paradigm and a parent-reported measure.</div></div><div><h3>Results</h3><div>There were positive associations between early postnatal testosterone and subsequent physical aggression outcomes in boys and in girls. Also, in boys, early postnatal testosterone and harsh parenting independently and interactively predicted subsequent parent-reported physical aggression; there was a positive association between testosterone and aggression when harsh parenting was high but not when harsh parenting was low.</div></div><div><h3>Conclusions</h3><div>The current findings suggest that early postnatal testosterone may exert organizing influences on physical aggression development in boys and in girls. Programs designed to reduce harsh parenting may buffer these early hormonal influences, especially in boys.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100579"},"PeriodicalIF":3.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Cerebral Blood Flow in Young Children With Prenatal Alcohol Exposure","authors":"Mohammad Ghasoub ,&nbsp;Madison Long ,&nbsp;Jamie Roeske ,&nbsp;Meaghan V. Perdue ,&nbsp;Xiangyu Long ,&nbsp;Carly McMorris ,&nbsp;Christina Tortorelli ,&nbsp;W. Ben Gibbard ,&nbsp;Catherine Lebel","doi":"10.1016/j.bpsgos.2025.100576","DOIUrl":"10.1016/j.bpsgos.2025.100576","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol exposure during pregnancy can hinder neurodevelopment, causing a range of behavioral and neurological deficits, including structural and functional brain alterations. Moreover, prenatal alcohol exposure (PAE) is associated with cerebral blood flow (CBF) abnormalities in preclinical models. However, it remains unclear to what extent CBF is affected by PAE in humans. In this study, we investigated CBF in young children with PAE.</div></div><div><h3>Methods</h3><div>A total of 171 scans collected from 99 children (35 children [51 scans] with PAE) between the ages of 3 to 8 years were examined. Children underwent a magnetic resonance imaging scan to acquire arterial spin labeling images to quantify CBF. CBF maps were segmented into 110 gray matter regions, and linear mixed models were used to test CBF differences between children with PAE and unexposed children in each region.</div></div><div><h3>Results</h3><div>Children with PAE had decreased CBF compared with unexposed control children, with the largest effects seen in subcortical and medial frontal regions.</div></div><div><h3>Conclusions</h3><div>CBF is negatively altered in children with PAE. CBF reductions may alter nutrient and oxygen delivery to the brain, resulting in impaired neurodevelopment and helping to explain functional deficits seen in PAE. The largest effects were seen in regions associated with cognitive and behavioral functions that are commonly impaired in individuals with PAE. Our findings contribute additional insight into the adverse effects of PAE on neurodevelopment and lay the groundwork for future studies to investigate CBF effects and how they relate to behavior.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100576"},"PeriodicalIF":3.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Immunologic Underpinnings of Post-Stroke Depression","authors":"Nina Vindegaard Sørensen ,&nbsp;Anders Hougaard ,&nbsp;Christina Kruuse ,&nbsp;Michael Eriksen Benros","doi":"10.1016/j.bpsgos.2025.100575","DOIUrl":"10.1016/j.bpsgos.2025.100575","url":null,"abstract":"<div><div>Post-stroke depression is a common consequence of stroke with an estimated prevalence of approximately 30% in stroke patients. It negatively impacts both rehabilitation and quality of life after stroke. Stroke induces an acute activation of the immune system in the central nervous system with concomitant immunologic alterations in the periphery. Immunologic alterations have been associated with non-stroke-related depression, and the evidence points to both central and peripheral immune activation with bidirectional interactions. By identifying and evaluating the current evidence of immunologic alterations associated with depression, stroke, and post-stroke depression, we outline the current knowledge and hypotheses on stroke-related immunologic alterations and associations with the subsequent risk of post-stroke depression. This includes immune system alterations in the cerebrospinal fluid and blood; pre- and post-stroke infections; the blood-brain barrier; autoimmunity of the central nervous system; brain imaging; the spleen-brain, gut-brain, and neuroendocrine-immune axes; and immunogenetic studies. All these topics are discussed within the context of post-stroke depression, pointing to a potential involvement of a multifactorial immunologic pathophysiology. In this narrative review, we identify key directions for future research and conclude by offering perspectives related to the therapeutic potential and associated challenges of this underinvestigated but important topic in neuropsychiatry.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100575"},"PeriodicalIF":3.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Emerging Role of the DDAH Proteins in Psychiatric Disorders","authors":"Magdalini R. Vareltzoglou ,&nbsp;Roman N. Rodionov ,&nbsp;Anthony C. Vernon ,&nbsp;Nadine Bernhardt","doi":"10.1016/j.bpsgos.2025.100574","DOIUrl":"10.1016/j.bpsgos.2025.100574","url":null,"abstract":"<div><div>The heterogeneous nature of psychiatric disorders complicates their clinical management and the development of novel treatments, imposing a significant burden on both patients and health care systems. To address these challenges, it is essential to continuously identify new targets involved in their pathogenesis. In this narrative review, we propose the dimethylarginine dimethylaminohydrolase (DDAH) proteins, already known for their significant role in cardiovascular disease, as promising novel treatment targets for psychiatric conditions. The DDAH proteins exist in 2 isoforms, DDAH1 and DDAH2, which both regulate nitric oxide homeostasis. DDAH1 metabolizes the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA), while DDAH2 acts through ADMA-independent mechanisms. We synthesize current evidence from systemic studies, genetic analyses, postmortem brain samples, and animal models to evaluate the potential roles of DDAH proteins across psychiatric conditions. Most systemic studies have revealed increased peripheral ADMA levels across several psychiatric disorders, including schizophrenia, depression, bipolar disorder, substance use disorders, and attention-deficit/hyperactivity disorder. Alterations in ADMA levels are also observed in transdiagnostic clinical domains such as cognitive deficits, sleep disturbances, white matter hyperintensities, and oxidative stress. These ADMA changes are evident from early stages of illness and respond to current treatments, suggesting diagnostic potential. Genetic and postmortem brain data further link DDAH1 and DDAH2 to psychiatric symptomatology in patient populations. Finally, fundamental studies in model systems provide insights into their role in neural proliferation, differentiation, cell death, and oxidative stress regulation—key processes in the developing and the adult brain. These data support the view that DDAH proteins may play a role in the molecular mechanisms that underlie psychiatric disorders and merit more investigation as potential therapeutic candidates.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100574"},"PeriodicalIF":3.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White Matter Regional Volumes in Relation to Menstrual Cycle Phase and Premenstrual Dysphoric Disorder","authors":"Elin Stenhammar ,&nbsp;Manon Dubol ,&nbsp;Louise Stiernman ,&nbsp;Inger Sundström-Poromaa ,&nbsp;Marie Bixo ,&nbsp;Erika Comasco","doi":"10.1016/j.bpsgos.2025.100573","DOIUrl":"10.1016/j.bpsgos.2025.100573","url":null,"abstract":"<div><h3>Background</h3><div>Premenstrual dysphoric disorder (PMDD) is an understudied, debilitating, and hormone-related mental disorder. Recent evidence suggests alterations in white matter structure during the symptomatic luteal phase in PMDD. In this study, white matter volumes (WMVs) in the brains of women with PMDD versus control women were compared across the menstrual cycle, to determine whether these differences reflect state- or trait-like characteristics.</div></div><div><h3>Methods</h3><div>Anatomical magnetic resonance imaging was performed during the midfollicular phase and the late luteal phase of the menstrual cycle in 28 women with PMDD and 27 control women. WMVs were assessed using voxel-based morphometry, employing both region-of-interest (ROI) and exploratory whole-brain approaches.</div></div><div><h3>Results</h3><div>No group-by-phase interaction effects on WMVs were found. Across menstrual cycle phases, women with PMDD exhibited greater WMVs than control women within ROIs (in the bilateral uncinate fasciculus, right inferior fronto-occipital fasciculus, and left crus and fimbria of the fornix) and across the whole brain (in inferior occipital areas and near the angular gyrus), indicating trait- rather than state-like structural markers of PMDD.</div></div><div><h3>Conclusions</h3><div>These findings suggest that women with PMDD exhibit larger WMVs than healthy control women, during both the symptomatic and asymptomatic phases of the menstrual cycle, in white matter tracts involved in emotion processing and regulation, memory, and connecting limbic and prefrontal regions of relevance to mood disorders.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100573"},"PeriodicalIF":3.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Neural Activities and Neuroplasticity Related to Nonpharmacological Interventions for Major Depressive Disorder: A Systematic Literature Review","authors":"Sandeep Vaishnavi ,&nbsp;Alex Leow ,&nbsp;Veronica Nguyen ,&nbsp;Chip Meyer ,&nbsp;Madeline Rose Keleher ,&nbsp;Caroline Leitschuh ,&nbsp;Tarolyn Carlton","doi":"10.1016/j.bpsgos.2025.100572","DOIUrl":"10.1016/j.bpsgos.2025.100572","url":null,"abstract":"<div><div>People with major depressive disorder (MDD) can have impaired neuroplasticity. Antidepressant treatment and some nonpharmacological interventions can lead to changes in neuroplasticity that improve MDD symptoms. However, there are no recent systematic literature reviews (SLRs) on the effect of nonpharmacological interventions for MDD on neuroplasticity. Therefore, we conducted an SLR of articles with primary results published between January 1, 2013, and December 6, 2023, that included adults with depression or MDD (MDD used to refer to both) treated with nonpharmacological products that are U.S. Food and Drug Administration (FDA) cleared and indicated for MDD or are investigative and need FDA review and clearance for use outside of clinical trials. From the 1257 records screened, 101 studies with 4746 participants were included. Electroconvulsive therapy was the most common treatment (used by 46.5% of the studies), followed by repetitive transcranial magnetic stimulation (35.6%). Of the 54 studies that included a healthy control comparison group, 42 (77.8%) found brain differences at baseline between the MDD group and the control group. Most of the studies (95 studies; 94.1%) found statistically significant functional or structural changes in the brain following nonpharmacological treatment for MDD. Of the 74 studies that investigated whether there was a relationship between changes in the brain and improvement in MDD symptoms, 53 (71.6%) found that changes in neuroplasticity corresponded with improvement in depression symptoms. This SLR shows that nonpharmacological interventions for MDD lead to changes in neuroplasticity, which correspond with improvement in MDD symptoms.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100572"},"PeriodicalIF":3.7,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Considerations in Assessing Fear Generalization as a Predictor of Anxiety","authors":"Yannik Stegmann ,&nbsp;Mario Reutter ,&nbsp;Katharina Hutterer ,&nbsp;Lea Hildebrandt ,&nbsp;Jürgen Deckert ,&nbsp;Lorenz Deserno ,&nbsp;Katharina Domschke ,&nbsp;Tina B. Lonsdorf ,&nbsp;Paul Pauli ,&nbsp;Andreas Reif ,&nbsp;Karoline Rosenkranz ,&nbsp;Miriam A. Schiele ,&nbsp;Dirk Schümann ,&nbsp;Peter Zwanzger ,&nbsp;Marta Andreatta ,&nbsp;Matthias Gamer","doi":"10.1016/j.bpsgos.2025.100570","DOIUrl":"10.1016/j.bpsgos.2025.100570","url":null,"abstract":"<div><h3>Background</h3><div>The ability to adaptively transfer acquired fear to novel situations is fundamental for survival in ever-changing environments and may contribute to the emergence and persistence of anxiety disorders. Consequently, research has focused on the assessment of fear generalization profiles to predict individual differences in anxiety. However, substantial heterogeneity in the operationalization of generalization hampers comparisons across studies and poses a risk to the replicability of findings.</div></div><div><h3>Methods</h3><div>To address these issues, we reviewed the literature to identify commonly used methods for characterizing perceptual fear generalization profiles. Then, we conducted simulation analyses to examine correlations between indices and probe their robustness against measurement noise. Finally, we used 2 large empirical datasets (<em>N</em> = 1175 and <em>N</em> = 256 healthy humans) to examine the reliability of these indices and their validity in predicting anxiety-related traits.</div></div><div><h3>Results</h3><div>All identified indices were substantially correlated but highly sensitive to measurement noise, with only minimal differences between methods. Reliabilities were moderate for subjective ratings but poor for skin conductance responses. All indices of fear generalization were unrelated to anxiety-related traits.</div></div><div><h3>Conclusions</h3><div>Overall, a more comprehensive discussion of conceptual and methodological issues is needed to enable informed decisions about how to reliably and validly estimate fear generalization and its relationship with anxiety-related traits or clinical symptoms.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100570"},"PeriodicalIF":3.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Critical Evaluation of Background Gene Omission in Imaging Transcriptomics","authors":"Zhipeng Cao ,&nbsp;Li Bao ,&nbsp;Jinmei Qin ,&nbsp;Guilai Zhan","doi":"10.1016/j.bpsgos.2025.100568","DOIUrl":"10.1016/j.bpsgos.2025.100568","url":null,"abstract":"<div><div>Imaging transcriptomics integrates spatial gene expression data with imaging-derived phenotypes (IDPs) to elucidate molecular mechanisms that underlie brain structure and function. Overrepresentation analysis (ORA) is widely used to annotate IDP-related genes; however, many studies have overlooked appropriate background gene selection. Here, we critically evaluated the impact of omitting a proper background on ORA findings. A systematic review of 152 imaging transcriptomics studies (2015–2024) revealed that 84.9% did not report background genes, and only 5.26% used the Allen Human Brain Atlas (AHBA) genes as background. Simulations showed that ORA significance increased with background size. In realistic simulations, default backgrounds (e.g., all protein-coding genes) inflated pathway significance by up to 50-fold, with probabilities reaching 0.97, particularly for frequently reported pathways related to synaptic signaling and neurotransmission. In contrast, using AHBA genes as the background maintained the significance probabilities near 0.05. These findings highlight the need for appropriate background selection and transparent reporting and we provide practical guidance for ORA in imaging transcriptomics.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100568"},"PeriodicalIF":3.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multimodal Observational Case-Control Study Exploring Gut Microbiota–Hippocampus Alterations in Individuals With High Positive Schizotypy From the General Population","authors":"Galya C. Iseli ,&nbsp;Jorge F. Vázquez-Castellanos ,&nbsp;David Coynel ,&nbsp;James M. Stone ,&nbsp;Mariana Zurita Soler ,&nbsp;Paul Allen ,&nbsp;Fernando Zelaya ,&nbsp;Muriel Derrien ,&nbsp;Undine E. Lang ,&nbsp;Martin Debbané ,&nbsp;Ulrich Ettinger ,&nbsp;Jeroen Raes ,&nbsp;André Schmidt","doi":"10.1016/j.bpsgos.2025.100567","DOIUrl":"10.1016/j.bpsgos.2025.100567","url":null,"abstract":"<div><h3>Background</h3><div>The hippocampus plays a critical role in psychosis, with reduced volume observed across the psychosis continuum. These structural changes are associated with cognitive deficits, symptom severity, and increased risk of psychosis progression. Elevated hippocampal perfusion and glutamate/GABA (gamma-aminobutyric acid) imbalance further suggest metabolic dysregulation as a key mechanism. Gut microbiota composition can influence hippocampal metabolism, but their interplay remains to be explored.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, we recruited 142 healthy participants from the general population, yielding 69 individuals with high schizotypy (HS) and 72 individuals with low schizotypy. All underwent clinical and cognitive testing, multimodal neuroimaging, and gut microbiota analysis via 16S ribosomal RNA gene sequencing. Hippocampal subfield volumes (structural magnetic resonance imaging), perfusion (arterial spin labeling) and glutamate/GABA levels (proton magnetic resonance spectroscopy), and microbial taxa (abundance, diversity, enterotypes) were assessed.</div></div><div><h3>Results</h3><div>Group comparisons of cognition, multimodal neuroimaging, and gut microbiome composition did not reveal significant differences after correction for multiple comparisons. Within the HS group, glutamate (<em>r</em> = 0.38, <em>p</em> = .003) and GABA (<em>r</em> = −0.36, <em>p</em> = .003) ratios were linked to social withdrawal. Across the entire sample, left hippocampal subfield volumes and glutamate/GABA levels differed significantly between predominant gut microbial enterotypes.</div></div><div><h3>Conclusions</h3><div>Our results suggest a potential relationship between aberrant gut microbial composition and hippocampal alterations in people with positive schizotypy from the general population. Our findings inform future large-scale research that further explores specific mechanisms of gut microbiome-hippocampus interactions in psychosis and the potential of tailored microbial interventions targeting hippocampal-mediated symptoms.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100567"},"PeriodicalIF":3.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Visuo-Tactile Temporal Binding Window Plasticity in Obsessive-Compulsive Disorder","authors":"Francesca Rastelli ,&nbsp;Davide Fausto Borrelli ,&nbsp;Francesca Ferroni ,&nbsp;Anna Di Donna ,&nbsp;Laura Dell’Uva ,&nbsp;Maurizio Cavazza ,&nbsp;Matteo Tonna ,&nbsp;Martina Ardizzi","doi":"10.1016/j.bpsgos.2025.100565","DOIUrl":"10.1016/j.bpsgos.2025.100565","url":null,"abstract":"<div><h3>Background</h3><div>Multisensory integration (MSI) enables the brain to combine sensory inputs by defining spatial and temporal boundaries that determine whether stimuli originate from the same event. Among these, the temporal binding window (TBW) specifically refers to the temporal range within which stimuli are perceived as simultaneous and integrated. In adulthood, TBW can be narrowed through short-term perceptual training. Altered TBW plasticity has been linked to neuropsychiatric conditions, where atypical prior weighting distorts sensory integration. This study investigates obsessive-compulsive disorder (OCD), a condition marked by heightened uncertainty and excessive reliance on real-time sensory input, potentially leading to wider MSI temporal boundaries and greater sensitivity to contingent sensory experiences.</div></div><div><h3>Methods</h3><div>In the current study, the TBW plasticity of 31 patients with OCD and 34 healthy control participants was studied by asking them to perform a simultaneity judgment task before and after a perceptual training session designed to narrow their TBW.</div></div><div><h3>Results</h3><div>Results showed a larger TBW with an abnormal tactile leading dominance in patients with OCD before the training session. Furthermore, patients with OCD showed a higher training gain than control participants.</div></div><div><h3>Conclusions</h3><div>These findings suggest altered TBW plasticity in OCD, potentially linked to difficulties in using past experiences as a stable source of information and an exaggerated reliance on real-time sensory input. Understanding these MSI alterations may offer new insights into the sensory mechanisms that underlie OCD and inform future research on sensory-based interventions.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100565"},"PeriodicalIF":3.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}