Biological psychiatry global open science最新文献

{"title":"Critical Importance of Multiple Time-Point Neuroimaging and Multimodal Integration in Elucidating Clinical Recovery Mechanisms","authors":"Sarah W. Yip , Anna B. Konova","doi":"10.1016/j.bpsgos.2025.100532","DOIUrl":"10.1016/j.bpsgos.2025.100532","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100532"},"PeriodicalIF":4.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Secondary Motor Cortex Neuronal Activity During Cocaine Self-Administration: Insights From Longitudinal In Vivo Calcium Imaging","authors":"Yingying Chen ,&nbsp;Haoying Fu ,&nbsp;Amith Korada ,&nbsp;Michal A. Lange ,&nbsp;Chandrashekar Rayanki ,&nbsp;Tao Lu ,&nbsp;Dongbing Lai ,&nbsp;Shiaofen Fang ,&nbsp;Changyong Guo ,&nbsp;Yao-Ying Ma","doi":"10.1016/j.bpsgos.2025.100531","DOIUrl":"10.1016/j.bpsgos.2025.100531","url":null,"abstract":"<div><h3>Background</h3><div>We recently reported that cocaine relapse risk is linked to hyperexcitability in the secondary motor cortex (M2) after prolonged withdrawal following intravenous self-administration (IVSA). However, the neuronal mechanisms underlying drug-taking behaviors and the response of M2 neurons to contingent drug delivery remain poorly understood.</div></div><div><h3>Methods</h3><div>Mice received cocaine as reinforcement (reinforcers [RNFs]) following active lever presses (ALPs) but not inactive lever presses (ILPs). Using miniScopes for in vivo calcium imaging during cocaine IVSA, we tracked M2 neuronal activity with single-cell resolution. Then we analyzed Ca²⁺ transients in the M2 at the early versus late stages during the 1-hour daily sessions on day 1 and day 5.</div></div><div><h3>Results</h3><div>M2 neurons adapted to both operant behaviors and drug exposure history. Specifically, saline mice showed a reduction in both saline-taking behaviors and Ca²⁺ transient frequency with the 1-hour session. In contrast, cocaine mice maintained high ALP and RNF counts, with increased Ca²⁺ transient frequency and amplitude on day 1, persisting through day 5. Compared with saline control mice, cocaine mice exhibited a lower percentage of positively responsive neurons and a higher percentage of negatively responsive neurons before ALPs and after RNFs, a difference not seen before ILPs. Furthermore, as drug-taking behaviors progressed during the daily session, cocaine mice showed greater neuronal engagement with a larger population, particularly linked to ALPs and RNFs, with reduced overlap in neurons associated with ILPs.</div></div><div><h3>Conclusions</h3><div>The M2 undergoes dynamic neuronal adaptations during drug-taking behaviors, supporting its role as a potential substrate mediating the persistence of drug-seeking behaviors in cocaine relapse.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100531"},"PeriodicalIF":4.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunometabolic Pathways: Investigating Mediators of Major Depressive Disorder and Atherosclerotic Cardiovascular Disease Comorbidity","authors":"Angela Koloi ,&nbsp;Nabila P.R. Siregar ,&nbsp;Rick Quax ,&nbsp;Antonis I. Sakellarios ,&nbsp;Femke Lamers ,&nbsp;Arja Rydin ,&nbsp;Kevin Dobretz ,&nbsp;Costas Papaloukas ,&nbsp;Dimitrios I. Fotiadis ,&nbsp;Jos A. Bosch","doi":"10.1016/j.bpsgos.2025.100528","DOIUrl":"10.1016/j.bpsgos.2025.100528","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) and cardiovascular diseases (CVDs) often co-occur whereby comorbidity results in poorer clinical outcomes, presumably due to shared immunometabolic pathways. Identifying shared biomarkers for MDD-CVD comorbidity may provide targets for prevention or treatment.</div></div><div><h3>Methods</h3><div>Using data from the NESDA (Netherlands Study of Depression and Anxiety) (<em>n</em> = 2256, 66.3% female, mean age 41.86 ± 13.08 years at baseline), validated with the UK Biobank (UKB) data (<em>n</em> = 35,668, 56.14% female, mean age 63.95 ± 7.74 years), this study aimed to identify 1) biomarkers, closely associated with current MDD, and 2) longitudinal pathways linking MDD and atherosclerotic CVD. Plasma metabolites (nuclear magnetic resonance) and inflammatory markers were used as exposures within a machine learning framework. Influential biomarkers were integrated into a temporal network analysis linking MDD to subsequent CVDs, exploring longitudinal pathways through causal discovery, validated by sensitivity analysis and centrality assessment. External validation included mediation and regression analysis adjusting for covariates.</div></div><div><h3>Results</h3><div>Network analysis identified stable direct paths from MDD to CVDs via tumor necrosis factor α (TNF-α), tyrosine, and fatty acids and indirect paths via acetate, high-density lipoprotein (HDL) diameter, interleukin 6, AGP, high-sensitivity C-reactive protein, and low-density lipoprotein triglycerides. Among these, acetate, tyrosine, AGP (α₁-acid glycoprotein), and HDL diameter potentially mediated the MDD-CVD connection, given that these were identified as key nodes within the network. UKB validation confirmed HDL diameter (β = 0.004) and AGP (β = 0.003) as significant depression-CVD mediators (both <em>p</em> &lt; .001), after adjusting for age, sex, deprivation index, alcohol consumption, smoking status, physical activity, and body mass index.</div></div><div><h3>Conclusions</h3><div>These analyses identified biomarkers shared in MDD and CVDs and may drive comorbid pathology risk.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100528"},"PeriodicalIF":4.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deconvolution-Based Transcriptomic Analysis in the Hippocampus Reveals Cell Type–Specific Risk Genes and Pathways Associated With Depression and Suicide","authors":"Aleena Francis,&nbsp;Bhaskar Roy,&nbsp;Yogesh Dwivedi","doi":"10.1016/j.bpsgos.2025.100530","DOIUrl":"10.1016/j.bpsgos.2025.100530","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) is a prevalent mental health condition with the highest associated suicide risk among major psychiatric disorders. Understanding the molecular and cellular mechanisms is crucial for assessing the risk of MDD and associated suicide.</div></div><div><h3>Methods</h3><div>In this study, transcriptome-based deconvolution was applied to human postmortem hippocampal samples from nonpsychiatric control subjects (<em>n</em> = 29), subjects with MDD who died by means other than suicide (D−S; <em>n</em> = 15), and subjects with MDD who died by suicide (D+S; <em>n</em> = 29). A reference gene expression profile for deconvolution was established using single-nucleus RNA sequencing (snRNA-Seq) analysis. The proportions of various cell types were assessed using the MuSiC2 package, and the cell type–specific gene expression was estimated from the bulk transcriptome using bMIND. Differential expression analysis using the deconvoluted expression profile was conducted to study cell type–specific gene regulation patterns in the hippocampi of patients with MDD who died by nonsuicidal or suicidal means.</div></div><div><h3>Results</h3><div>The snRNA-Seq analysis identified 11 major cell types in the hippocampus, which were consolidated into 5 primary categories: pyramidal, GABAergic (gamma-aminobutyric acidergic), microglia, macroglia, and endothelial cells. Variability in the cell-type proportions was noted among the sample groups, and the gene expression deconvolution showed distinct patterns among cell types and sample groups. Differential expression analysis at the cell-type level identified more differentially expressed genes than the bulk transcriptome, with variations across comparisons and cell types. Notably, pyramidal neurons displayed significant contrasts between D−S and D+S subjects; the former group exhibited enrichment in cytoskeleton-related pathways and molecular functions, while the latter demonstrated a prevalence of immune-related terms.</div></div><div><h3>Conclusions</h3><div>The distinct cell type–specific transcriptomic patterns, gene networks, and pathways reveal critical vulnerabilities associated with suicidality in individuals with MDD. These findings underscore the potential for targeted interventions aimed at these specific molecular pathways to mitigate suicide risk in individuals with depression.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100530"},"PeriodicalIF":4.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway Inflammation","authors":"Maxie Liebscher ,&nbsp;Claire Laubacher ,&nbsp;Theodore P. Imhoff-Smith ,&nbsp;Rasmus M. Birn ,&nbsp;Danika R. Klaus ,&nbsp;Corrina J. Frye ,&nbsp;William W. Busse ,&nbsp;Melissa A. Rosenkranz","doi":"10.1016/j.bpsgos.2025.100527","DOIUrl":"10.1016/j.bpsgos.2025.100527","url":null,"abstract":"<div><h3>Background</h3><div>Asthma and depression frequently co-occur, potentially worsening each other’s symptoms. The salience network (SN) may play a key role in this link, but the roles of the default mode network (DMN) and frontoparietal network (FPN), as outlined in the triple network theory, remain unclear in the asthma-depression connection. This longitudinal study investigated pre-post changes in graph-theory metrics within and between the 3 networks in individuals with asthma and how these relate to depressive symptoms.</div></div><div><h3>Methods</h3><div>Twenty-four individuals with asthma underwent functional magnetic resonance imaging scans pre- and postsegmental allergen challenge. Depressive symptoms were assessed at baseline using the Beck Depression Inventory. Changes in graph-theory metrics were analyzed using region-of-interest (ROI)-to-ROI analyses, controlling for sex.</div></div><div><h3>Results</h3><div>Allergen challenge led to changes in network properties. Within-network analyses showed decreased degree centrality (β = 0.50, false discovery rate–corrected <em>p</em> [<em>p</em>_FDR] = .004) and betweenness centrality (β = 0.10, <em>p</em>_FDR = .025) of the posterior cingulate cortex (DMN) and reduced degree centrality of the anterior cingulate cortex (SN), which correlated with depressive symptoms (β = 0.05, <em>p</em>_FDR = .017). Between-network analyses showed reduced closeness centrality in the bilateral lateral parietal during SN-DMN interactions (right: β = 0.23, <em>p</em>_FDR = .010; left: β = 0.23, <em>p</em>_FDR = .013) and increased degree centrality in the left posterior parietal cortex during SN-FPN interactions (β = −0.10, <em>p</em>_FDR = .038), which correlated with depressive symptoms.</div></div><div><h3>Conclusions</h3><div>Allergen challenge alters graph-theory metrics within and between resting-state networks, with changes linked to depression symptoms. Findings highlight the SN’s critical role in network switching and its vulnerability to inflammation in asthma-depression connection.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100527"},"PeriodicalIF":4.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Topologies of Reinforcement Sensitivity Theory: A Latent Variable Approach to Magnetic Resonance Imaging Data","authors":"Elena Lacomba-Arnau ,&nbsp;Agustín Martínez-Molina ,&nbsp;Luis Eduardo Garrido ,&nbsp;Alfonso Barrós-Loscertales","doi":"10.1016/j.bpsgos.2025.100526","DOIUrl":"10.1016/j.bpsgos.2025.100526","url":null,"abstract":"<div><h3>Background</h3><div>The reinforcement sensitivity theory (RST) proposes 3 neurobiological systems that underlie individual differences in sensitivity to reward, punishment, and motivational conflicts. From a latent variable perspective, theoretical model structures can be identified based on empirical data. We applied exploratory and confirmatory factor analyses as well as structural equation modeling (SEM) with the aim of evaluating the RST neurobiological systems from biological phenotype indicators based on brain morphological organization.</div></div><div><h3>Methods</h3><div>We analyzed magnetic resonance imaging (MRI) data from 300 healthy adults (128 female, 172 male) using gray matter volumes extracted through the Neuromorphometrics atlas, targeting RST-related brain systems. To assess the underlying structure of RST neurobiological systems, we used principal component analysis, confirmatory factor analysis, exploratory factor analysis, and exploratory SEM, as well as its model hierarchy. All analyses were enhanced by advanced techniques such as parallel analysis and exploratory graph analysis.</div></div><div><h3>Results</h3><div>The findings reveal a robust 4-factor model: the behavioral activation system, the combined behavioral inhibition and fight-flight-freeze system, and a dual constraint system with dorsal cortical stream and ventral cortical stream. The dorsal cortical stream exhibited significant integrative capacity, impacting the model hierarchy through top-down projections on all the other systems. Exploratory SEM provided the best fit to the MRI data, underscoring its suitability for summarizing neural substrate data.</div></div><div><h3>Conclusions</h3><div>This study provides insights into the neurobiological foundations of RST, proposing a structural brain topology that is consistent with the theoretical proposal and emerging empirical evidence in human research. The results support the integration of psychological constructs with biological phenotypes.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100526"},"PeriodicalIF":4.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilevel Neuroimaging Insights Into Electroconvulsive Therapy Mechanisms in Clozapine-Refractory Schizophrenia: A Comparative Perspective With Depression","authors":"Maarten Laroy ,&nbsp;Akihiro Takamiya ,&nbsp;Filip Bouckaert","doi":"10.1016/j.bpsgos.2025.100529","DOIUrl":"10.1016/j.bpsgos.2025.100529","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100529"},"PeriodicalIF":4.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Digital Therapy: Augmenting Internet-Based Cognitive Behavioral Therapy With Brain Stimulation","authors":"Willians F. Vieira","doi":"10.1016/j.bpsgos.2025.100514","DOIUrl":"10.1016/j.bpsgos.2025.100514","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100514"},"PeriodicalIF":4.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gut Microbiome and Emotional Distress During Pregnancy: Shaking the Foundations of Future Mental Health?","authors":"Gerard Clarke ,&nbsp;John F. Cryan ,&nbsp;Siobhain M. O’Mahony","doi":"10.1016/j.bpsgos.2025.100518","DOIUrl":"10.1016/j.bpsgos.2025.100518","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100518"},"PeriodicalIF":4.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Species Evidence for Psilocin-Induced Visual Distortions: Apparent Motion Is Perceived by Both Humans and Rats","authors":"Čestmír Vejmola ,&nbsp;Klára Šíchová ,&nbsp;Kateřina Syrová ,&nbsp;Lucie Janečková ,&nbsp;Vlastimil Koudelka ,&nbsp;Michael Tesař ,&nbsp;Marek Nikolič ,&nbsp;Michaela Viktorinová ,&nbsp;Filip Tylš ,&nbsp;Jakub Korčák ,&nbsp;Vojtěch Viktorin ,&nbsp;Eduard Kelemen ,&nbsp;Tereza Nekovářová ,&nbsp;Martin Brunovský ,&nbsp;Jiří Horáček ,&nbsp;Martin Kuchař ,&nbsp;Tomáš Páleníček","doi":"10.1016/j.bpsgos.2025.100524","DOIUrl":"10.1016/j.bpsgos.2025.100524","url":null,"abstract":"<div><h3>Background</h3><div>Psychedelics, particularly psilocin, are increasingly being studied for their mind-altering effects and potential therapeutic applications in psychiatry. Visual hallucinations, especially the illusion of motion in static images, are a hallmark of their action. Despite growing interest, the underlying mechanisms remain poorly understood, as their systematic evaluation in both humans and animals is challenging.</div></div><div><h3>Methods</h3><div>To investigate psilocin-induced visual distortions, we designed a 2-choice visual discrimination task. Human participants and male rats indicated whether an image appeared static or moving while the image either actually moved or did not. In humans, performance was compared with self-reported hallucination intensity, Altered States of Consciousness scale scores, and psilocin plasma levels. Rats were tested in 2 distinct tasks, a luminance-based task and a motion-based task. Their performance was evaluated alongside decision time.</div></div><div><h3>Results</h3><div>Both species exhibited significant impairment in distinguishing static from dynamic visual stimuli while under psilocin’s influence. In humans, this impairment followed the time course of psilocin plasma levels and hallucination intensity. In rats, psilocin selectively impaired performance in the motion-based task, while performance in the luminance-based task remained intact, indicating a specific effect on visual perception. Decision time was linked to discrimination impairment.</div></div><div><h3>Conclusions</h3><div>Psilocin impaired static-dynamic discrimination in both species, providing the first evidence that rats experience visual distortions similar to those reported by humans. The correlations between discrimination impairment, psilocin levels, and hallucination intensity in humans reinforce psilocin’s effects on visual perception. This approach provides a valuable tool for investigating the neurobiology of altered visual perception in drug-induced states and psychiatric conditions.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100524"},"PeriodicalIF":4.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}