Chloe A. Dziego , Anthony P. Zanesco , Ina Bornkessel-Schlesewsky , Matthias Schlesewsky , Elizabeth A. Stanley , Amishi P. Jha
{"title":"Mindfulness Training in High-Demand Cohorts Alters Resting-State Electroencephalography: An Exploratory Investigation of Individual Alpha Frequency, Aperiodic 1/f Activity, and Microstates","authors":"Chloe A. Dziego , Anthony P. Zanesco , Ina Bornkessel-Schlesewsky , Matthias Schlesewsky , Elizabeth A. Stanley , Amishi P. Jha","doi":"10.1016/j.bpsgos.2024.100383","DOIUrl":"10.1016/j.bpsgos.2024.100383","url":null,"abstract":"<div><h3>Background</h3><div>Mindfulness training (MT) programs have demonstrated utility as cognitive training tools, but there is little consensus on the neurophysiological processes that may underlie its benefits. It has been posited that intrinsic brain activity recorded at rest reflects the functional connectivity of large-scale brain networks and may provide insight into neuroplastic changes that support MT. In the current study, we indexed changes in several resting-state electroencephalography (EEG) parameters to investigate the neurophysiological underpinnings of MT.</div></div><div><h3>Methods</h3><div>Resting-state EEG data were collected from active-duty U.S. military personnel (<em>N</em> = 80) at 2 testing sessions: before (time [T] 1) and after (T2) engaging in an 8-week MT or active comparison intervention (positivity training). We examined longitudinal and/or groupwise differences in several EEG parameters through parameterization of power spectra (individual alpha frequency and 1/<em>f</em> activity) and microstate analysis.</div></div><div><h3>Results</h3><div>While no significant group × time differences were observed in individual alpha frequency, significant group × time effects were observed in several EEG parameters from T1 to T2. Compared with MT, positivity training was associated with a steepening of the 1/<em>f</em> slope and higher 1/<em>f</em> intercepts together with decreased duration and increased global field power of microstates.</div></div><div><h3>Conclusions</h3><div>Taken together, these results suggest that the effects of interventions may be differentiated in resting-state brain activity in a sample of military personnel. Such findings provide insight into the neural underpinnings of MT-related brain changes, but more research is required to elucidate how these may relate to task-related neural and performance changes with MT and whether results generalize to other mindfulness interventions in alternative cohorts and contexts.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100383"},"PeriodicalIF":4.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Max Mitchell , Aleksandra Spasova , Yasir Ahmed Syed
{"title":"Unraveling Autism: Using Brain Organoids to Investigate Sex Differences in Brain Development","authors":"Max Mitchell , Aleksandra Spasova , Yasir Ahmed Syed","doi":"10.1016/j.bpsgos.2024.100360","DOIUrl":"10.1016/j.bpsgos.2024.100360","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100360"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000739/pdfft?md5=bc500a2ce56e3353322cc205a4404926&pid=1-s2.0-S2667174324000739-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Awe and Other Psychological Factors in Ketamine’s Mechanism of Antidepressant Action","authors":"Mina Ansari, Gerard Sanacora","doi":"10.1016/j.bpsgos.2024.100353","DOIUrl":"10.1016/j.bpsgos.2024.100353","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100353"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000661/pdfft?md5=924fa03072b6fb44d861a5f3b5ba472c&pid=1-s2.0-S2667174324000661-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2667-1743(24)00091-0","DOIUrl":"10.1016/S2667-1743(24)00091-0","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100378"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000910/pdfft?md5=6a74f031fb574bfb7000fd1611e85e4f&pid=1-s2.0-S2667174324000910-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Targeting Deep Structures to Noninvasively Modulate Fear and Anxiety","authors":"Odile A. van den Heuvel","doi":"10.1016/j.bpsgos.2024.100363","DOIUrl":"10.1016/j.bpsgos.2024.100363","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100363"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000764/pdfft?md5=43def89ddc2febe61c7dd1e0fcdf8600&pid=1-s2.0-S2667174324000764-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Subscribers Page","authors":"","doi":"10.1016/S2667-1743(24)00092-2","DOIUrl":"10.1016/S2667-1743(24)00092-2","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100379"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000922/pdfft?md5=8a2165ec857ba0671393b030659b1bd9&pid=1-s2.0-S2667174324000922-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurobiological Underpinnings of Adolescent Susceptibility to Stress","authors":"Patricio O’Donnell","doi":"10.1016/j.bpsgos.2024.100364","DOIUrl":"10.1016/j.bpsgos.2024.100364","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100364"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000776/pdfft?md5=1d3fff78f9f4487e8d581b0ac1ca8851&pid=1-s2.0-S2667174324000776-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Negative Schizotypy: Now That We Know What It Is, Should We Do Something About It?","authors":"Philip D. Harvey","doi":"10.1016/j.bpsgos.2024.100354","DOIUrl":"10.1016/j.bpsgos.2024.100354","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100354"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000673/pdfft?md5=cb5e1b98eb5d0e69b1f2617a23648720&pid=1-s2.0-S2667174324000673-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Guide for Authors","authors":"","doi":"10.1016/S2667-1743(24)00094-6","DOIUrl":"10.1016/S2667-1743(24)00094-6","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100381"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000946/pdfft?md5=e4c107b2955882d1f85d260b960e176f&pid=1-s2.0-S2667174324000946-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Borderline Personality Disorder Symptoms and Stressful Life Events: An Evaluation of Gene-Environment Interplay","authors":"Vilde Sofie Arneberg , Vilde Sundsvold , Ludvig Daae Bjørndal , Eivind Ystrom","doi":"10.1016/j.bpsgos.2024.100390","DOIUrl":"10.1016/j.bpsgos.2024.100390","url":null,"abstract":"<div><h3>Background</h3><div>Borderline personality disorder (BPD) is associated with high rates of stressful life events (SLEs). It is unclear whether people who experience SLEs have more BPD symptoms after accounting for the effects of familial risk factors. Our aims in the current study were to 1) create a predictive model of BPD using stressors across age and contexts and 2) examine whether SLEs resulted in higher levels of BPD symptoms beyond the effects of genetic and environmental risk factors.</div></div><div><h3>Methods</h3><div>The sample comprised 2801 twins from the Norwegian Institute of Public Health Twin Panel. Poisson regression was used to explore which SLEs predicted BPD symptoms. Elastic net penalized regression was conducted to develop a predictive model for SLEs and BPD symptoms. Co-twin control analyses were performed to differentiate between environmental and genetic factors.</div></div><div><h3>Results</h3><div>SLEs experienced during childhood and adulthood were associated with BPD symptoms. A weighted polyevent risk score explained 22% of the total variation in symptoms. Shared environmental and heritable factors explained 31% and 47% of individual differences in BPD symptomatology, respectively. Measured SLEs explained 42% of the shared environmental risk for BPD. The predictive risk of SLEs for BPD was reduced when shared environmental and genetic factors were accounted for. However, SLEs increased risk of BPD symptoms beyond the effects of shared genetic and environmental factors.</div></div><div><h3>Conclusions</h3><div>BPD symptomatology following SLEs cannot fully be explained by genetic and shared environmental factors. The SLE-BPD symptoms associations were primarily due to selection by family environments. It is important to identify familial factors that lead to both SLEs and BPD symptoms. SLEs remained associated with BPD symptoms beyond genetic and environmental confounding.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100390"},"PeriodicalIF":4.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}