Biological psychiatry global open science最新文献

{"title":"Somatomotor Disconnection Links Sleep Duration With Socioeconomic Context, Screen Time, Cognition, and Psychopathology","authors":"Cleanthis Michael ,&nbsp;Aman Taxali ,&nbsp;Mike Angstadt ,&nbsp;Katherine L. McCurry ,&nbsp;Alexander Weigard ,&nbsp;Omid Kardan ,&nbsp;M. Fiona Molloy ,&nbsp;Katherine Toda-Thorne ,&nbsp;Lily Burchell ,&nbsp;Maria Dziubinski ,&nbsp;Jason Choi ,&nbsp;Melanie Vandersluis ,&nbsp;Luke W. Hyde ,&nbsp;Mary M. Heitzeg ,&nbsp;Chandra Sripada","doi":"10.1016/j.bpsgos.2025.100522","DOIUrl":"10.1016/j.bpsgos.2025.100522","url":null,"abstract":"<div><h3>Background</h3><div>Sleep is critical for healthy brain development and emotional well-being, especially during adolescence, when sleep, behavior, and neurobiology are rapidly evolving. Theoretical reviews and empirical research have historically focused on how sleep influences mental health through its impact on higher-order brain systems. No studies have leveraged data-driven network neuroscience methods to uncover interpretable, brainwide signatures of sleep duration in adolescence, their socioenvironmental origins, and their consequences for cognition and psychopathology.</div></div><div><h3>Methods</h3><div>We implemented graph theory and component-based predictive modeling to examine how a multimodal index of sleep duration (parent-report, youth-report, Fitbit) is associated with intrinsic brain architecture in 3037 youths (ages 11–12 years) from the ABCD (Adolescent Brain Cognitive Development) Study.</div></div><div><h3>Results</h3><div>We demonstrated that network integration/segregation exhibited a strong, generalizable multivariate association with sleep duration (<em>r</em> = 0.23, <em>p</em> &lt; .001). The multivariate signature of shorter sleep predominantly involved increasing disconnection of a lower-order system, the somatomotor network, from other systems. Next, we identified a single component of brain architecture as the dominant contributor of this relationship (<em>r</em> = 0.15), which again exhibited this somatomotor disconnection motif. Finally, greater somatomotor disconnection was associated with lower socioeconomic resources, longer screen times, reduced cognitive/academic performance, and elevated externalizing problems (βs &gt; 0.03, <em>p</em>s ≤ .007).</div></div><div><h3>Conclusions</h3><div>These findings reveal a novel neural signature of shorter sleep in adolescence that is intertwined with environmental risk, cognition, and psychopathology. By robustly elucidating the key involvement of an understudied brain system in sleep, this study can inform theoretical and translational research directions on sleep to promote neurobehavioral development and mental health during the adolescent transition.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100522"},"PeriodicalIF":4.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumption of the Prebiotic-Rich Chicory Taproot Contrasts the Cognitive and Motivational Consequences of Chronic Corticosterone Exposure and Modulates Gut Microbiota Composition in Mice","authors":"Francesca Zoratto ,&nbsp;Edoardo Pisa ,&nbsp;Claudia Soldati ,&nbsp;Martina Di Bartolomeo ,&nbsp;Gabriele Paglialunga ,&nbsp;Alessandro Piccinini ,&nbsp;Marta Del Bianco ,&nbsp;Stefano Moscatello ,&nbsp;Simona Proietti ,&nbsp;Stefano Lorenzetti ,&nbsp;Paolo Colangelo ,&nbsp;Claudio D’Addario ,&nbsp;Alberto Battistelli ,&nbsp;Simone Macrì","doi":"10.1016/j.bpsgos.2025.100520","DOIUrl":"10.1016/j.bpsgos.2025.100520","url":null,"abstract":"<div><h3>Background</h3><div>The human gastrointestinal tract harbors trillions of microbes that act in synergy with the brain to regulate its homeostasis and function. This interplay holds promise for innovative dietary-based interventions to support cognitive and motivational processes or contrast their decline in disease. While probiotics have traditionally been used for such interventions, several limitations have hampered their suitability and incited interest in prebiotics. Fructans represent a valid prebiotic whereby they are abundant in several vegetables (e.g., chicory taproots) and increase short-chain fatty acids (SCFAs) production via fermentation by gut microbes. SCFAs have been reported to modulate gene expression in the brain via epigenetic mechanisms. Here, we investigated whether chicory taproots may represent a strategy to contrast cognitive and motivational impairments induced by chronic corticosterone administration.</div></div><div><h3>Methods</h3><div>To test our hypothesis, we exposed C57BL/6 male mice (<em>n</em> = 18 per group) to corticosterone supplementation in drinking water and provided them with a fructan-rich diet (regular diet enriched with dried chicory taproots).</div></div><div><h3>Results</h3><div>Consistent with our hypothesis, chicory taproot consumption promoted the growth of selected microbial species and increased SCFA concentrations. To verify the functional role of these modulations, using a comprehensive behavioral test battery, we observed that chicory taproots contrasted the cognitive and motivational consequences of chronic corticosterone exposure. These behavioral modifications were associated with a modulation of gene expression and its epigenetic regulators in brain regions relevant for cognition and motivation.</div></div><div><h3>Conclusions</h3><div>These results highlight the role of prebiotics in preserving higher-order brain functions and offer insights into their therapeutic potential.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100520"},"PeriodicalIF":4.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Induction of Dissociative States: A Meta-Analysis","authors":"Benjamin Brake ,&nbsp;Lillian Wieder ,&nbsp;Natasha Hughes ,&nbsp;Ivonne Saravia Lalinde ,&nbsp;Danielle Marr ,&nbsp;Dali Geagea ,&nbsp;Susannah Pick ,&nbsp;Antje A.T.S. Reinders ,&nbsp;Sunjeev K. Kamboj ,&nbsp;Trevor Thompson ,&nbsp;Devin B. Terhune","doi":"10.1016/j.bpsgos.2025.100521","DOIUrl":"10.1016/j.bpsgos.2025.100521","url":null,"abstract":"<div><h3>Background</h3><div>Dissociative states, characterized by discontinuities in awareness and perception, occur in a diverse array of psychiatric disorders and contexts. These states have been experimentally modeled in the laboratory through various induction methods, but relatively little is known about the efficacy and comparability of different experimental methods.</div></div><div><h3>Methods</h3><div>In this meta-analysis, we quantified dissociative states, as indexed by a standardized instrument (Clinician-Administered Dissociative States Scale), at baseline in varied diagnostic categories and in response to different experimental induction methods (psychological techniques and pharmacological agents) in both clinical and nonclinical samples. Primary outcomes were state dissociation effect sizes (Hedges’ <em>g</em>) (PROSPERO registration: <span><span>CRD42022384886</span><svg><path></path></svg></span>). A total of 2214 articles were screened, which yielded 123 eligible articles and 155 effect sizes comprising 6692 individuals.</div></div><div><h3>Results</h3><div>High levels of baseline state dissociation were observed in multiple diagnostic categories relative to controls, with the largest effects found in the dissociative and complex subtypes of posttraumatic stress disorder (PTSD-DC). In controlled experiments, induced state dissociation was most pronounced in response to mirror gazing and multiple pharmacological agents, with effects in ketamine and cannabis exceeding baseline state dissociation in PTSD-DC. The effect sizes were characterized by pronounced heterogeneity but were not reliably associated with methodological features of the original studies.</div></div><div><h3>Conclusions</h3><div>Elevated state dissociation is present in multiple diagnostic categories, and comparable or higher levels can be reliably induced in controlled experiments using psychological techniques and pharmacological agents. These results demonstrate the efficacy of several methods for experimentally modeling dissociation and have implications for measuring adverse events and predicting outcomes in clinical interventions that involve pharmacological agents.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100521"},"PeriodicalIF":4.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of Sex Differences in Psychostimulant-Induced Locomotor Activity When Comparing Rats From the Same Behavioral Groups","authors":"Anthony M. Tigano,&nbsp;Martin O. Job","doi":"10.1016/j.bpsgos.2025.100519","DOIUrl":"10.1016/j.bpsgos.2025.100519","url":null,"abstract":"<div><h3>Background</h3><div>We hypothesized that sex differences in baseline-, saline-, and psychostimulant-induced locomotor activity (LMA) would not be observed when we compared males and females that belonged to the same behavioral group(s). Our aim was to determine whether we could detect differences between males and females within a truly distinct behavioral group. To identify behavioral groups, current models use median-split analysis typically of one variable, but this procedure may not be effective. With the rationale that clustering analysis of several variables is a more robust grouping strategy, we developed a new model termed the MISSING (Mapping Intrinsic Sex Similarities as an Integral quality of Normalized Groups) model to test our hypothesis.</div></div><div><h3>Methods</h3><div>We obtained baseline LMA, drug-induced LMA, and a new variable that integrates both baseline and drug-induced LMA (drug-induced LMA normalized-to-baseline activity-time) from LMA assessments following saline (males <em>n</em> = 12, females <em>n</em> = 11) and cocaine 10 mg/kg (male <em>n</em> = 22, female <em>n</em> = 23) intraperitoneal injections, and intra–nucleus accumbens dopamine 15 μg/side (male <em>n</em> = 20, female <em>n</em> = 17). Using regression analysis and analysis of variance, we compared the MISSING model with the current model for effectiveness in identifying distinct groups.</div></div><div><h3>Results</h3><div>The MISSING model was superior to the median split in distinct behavioral group identification. For both models, we confirmed that there were no differences in psychostimulant-induced LMA when we compared males and females within the same group/cluster.</div></div><div><h3>Conclusions</h3><div>There were no sex differences in psychostimulant-induced LMA when we compared rats from the same behavioral group(s).</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100519"},"PeriodicalIF":4.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Interplay Between Attention-Deficit/Hyperactivity Disorder and Pain Suggests Neurodevelopmental Pathways and Comorbidity Risk","authors":"Nicolas P. Ciochetti ,&nbsp;Victor F. de Oliveira ,&nbsp;Iago Junger-Santos ,&nbsp;Cibele E. Bandeira ,&nbsp;Maria E. Tavares ,&nbsp;Eduardo S. Vitola ,&nbsp;Luis A. Rohde ,&nbsp;Gustavo Melo de Andrade ,&nbsp;Bruna S. da Silva ,&nbsp;Eugenio H. Grevet ,&nbsp;Claiton H. Dotto Bau ,&nbsp;Diego L. Rovaris","doi":"10.1016/j.bpsgos.2025.100517","DOIUrl":"10.1016/j.bpsgos.2025.100517","url":null,"abstract":"<div><h3>Background</h3><div>In this study, we investigated the genetic connections between attention-deficit/hyperactivity disorder (ADHD), migraine (MGN), and multisite chronic pain (MCP). The goal was to identify specific shared biological mechanisms that contribute to the overlap between ADHD and these pain-related conditions.</div></div><div><h3>Methods</h3><div>We utilized various post–genome-wide association study analyses on summary data from samples ranging between 225,534 and 766,345 individuals. In an independent sample of patients with ADHD and control participants (665 cases and 995 controls), we evaluated MGN and MCP polygenic risk scores (PRSs) in relation to comorbid profiles, symptom severity, and neuroimaging brain scores.</div></div><div><h3>Results</h3><div>The findings show a strong biological overlap between ADHD and MCP, with a less pronounced relationship with MGN. Key regions and genes associated with ADHD and MCP were enriched in neurodevelopmental pathways, including those involved in neuron projection morphogenesis and nervous system development. Drug-set enrichment analysis identified that some of these pathways are potentially influenced by paracetamol, a drug that has been implicated as a class I environmental risk factor for ADHD when exposure occurs prenatally. Causal inference analysis using a 5-fold larger ADHD summary dataset demonstrated stronger effects of MCP on ADHD than the reverse. In the independent sample, higher MCP PRSs were linked to structural brain features, increased comorbidity with substance use and bipolar disorder, and heightened severity of ADHD symptoms.</div></div><div><h3>Conclusions</h3><div>These findings underscore the significant genetic relationship between ADHD and MCP, suggesting that shared genetic factors may influence brain development and contribute to diverse clinical outcomes in ADHD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100517"},"PeriodicalIF":4.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obsessive–Compulsive Symptoms and Heterozygous Microduplication of the RB1CC1 Gene","authors":"Alexander Maier ,&nbsp;Katharina von Zedtwitz ,&nbsp;Simon J. Maier ,&nbsp;Bernd Feige ,&nbsp;Marco Reisert ,&nbsp;Volker A. Coenen ,&nbsp;Alexander Rau ,&nbsp;Raphael J. Dressle ,&nbsp;Kathrin Nickel ,&nbsp;Miriam A. Schiele ,&nbsp;Birgitta Gläser ,&nbsp;Katharina Domschke ,&nbsp;Katalin Komlosi ,&nbsp;Dominique Endres","doi":"10.1016/j.bpsgos.2025.100516","DOIUrl":"10.1016/j.bpsgos.2025.100516","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100516"},"PeriodicalIF":4.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional Molecular Changes in Chronic Lipopolysaccharide-Induced Neuroinflammation","authors":"Leandrie Pienaar,&nbsp;Adalayne Ramsamy,&nbsp;Aletta M.E. Millen,&nbsp;Sooraj Baijnath","doi":"10.1016/j.bpsgos.2025.100515","DOIUrl":"10.1016/j.bpsgos.2025.100515","url":null,"abstract":"<div><h3>Background</h3><div>Neuroinflammation is linked to the development of depression. Exposure to the proinflammatory endotoxin lipopolysaccharide (LPS) is associated with a depressive-like phenotype in rodents. However, acute LPS exposure may reflect sickness behavior, and thus the molecular mechanisms and neurobehavioral changes associated with chronic neuroinflammation warrant investigation.</div></div><div><h3>Methods</h3><div>Using male Sprague Dawley rats (<em>N</em> = 37) we investigated the impact of systemic inflammation, following a single or multiple doses of LPS on neurobehavioral outcomes and brain regional gene expression of inflammatory, neurotrophic and apoptotic markers in the prefrontal cortex, striatum, hippocampus, hypothalamus, midbrain, cortex, and cerebellum.</div></div><div><h3>Results</h3><div>LPS administration induced systemic inflammation and subsequent neuroinflammation, as evidenced by increased circulating concentrations and regional expression of proinflammatory cytokines (<em>Tnf-α</em> and <em>Il1β</em>) in both short-term (ST) and long-term (LT) groups. Single LPS administration reduced the time spent in the center of the open field test after one week, while sucrose consumption was reduced with repeated LPS exposure. LPS showed a time- and region-specific effect on the expression of neurotrophins, as evidenced by increased messenger RNA expression of <em>Ngf</em> and <em>Nt-3</em> in both the ST-LPS and LT-LPS groups, while <em>Bdnf</em> and <em>Il6</em> expression was increased only in the LT-LPS group, and <em>Creb</em> expression was increased only in the ST-LPS group.</div></div><div><h3>Conclusions</h3><div>Taken together, our findings suggest that in LPS-induced systemic inflammation, <em>Tnf-α</em> and <em>Il1β</em> drive region-specific neurodegeneration via apoptotic processes, while <em>Il6</em> and its regulatory interaction with neurotrophins may serve as a protective mechanism in neuroinflammation.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100515"},"PeriodicalIF":4.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Direct and Moderating Effects of Social Connectedness and Perceived Social Support on Suicidal Ideation in Older Adults With Depression: A Prospective Study","authors":"Madison Stoms ,&nbsp;Anna Szücs ,&nbsp;Yanni Wang ,&nbsp;Katalin Szanto ,&nbsp;Hanga Galfalvy","doi":"10.1016/j.bpsgos.2025.100513","DOIUrl":"10.1016/j.bpsgos.2025.100513","url":null,"abstract":"<div><h3>Background</h3><div>Maintaining one’s social capital may protect older adults with depression from contemplating suicide, possibly by contributing to overall well-being and mitigating the negative effects of arising difficulties such as worsening mental or physical health. However, it remains unclear whether such protective overall and mitigating effects stem primarily from the size and diversity of one’s social network (social connectedness) or from the feeling of being supported by others (perceived social support) and whether these effects persist over time.</div></div><div><h3>Methods</h3><div>In a longitudinal sample of adults with depression ages ≥50 years (<em>N</em> = 287, mean age = 64 years, mean follow-up time = 2 years), with most participants having suicidal ideation (<em>n</em> = 203), zero-inflated negative binomial regression models were used to prospectively evaluate whether social connectedness and perceived social support measured at baseline decreased the presence and severity of suicidal ideation, and whether they moderated the unfavorable effect of baseline depression severity and physical illness on ideation presence and severity at baseline and during short- and long-term follow-ups.</div></div><div><h3>Results</h3><div>In prospective models, both ideation presence and ideation severity decreased with social connectedness (ideation presence: odds ratio = 0.77, SE = 0.10, <em>p</em> = .003; ideation severity: rate ratio [RR] = 0.84, SE = 0.05, <em>p</em> = .005). Perceived social support only decreased ideation severity (RR = 0.64, SE = 0.05, <em>p</em> &lt; .001). No moderation effect with social health measures reached significance.</div></div><div><h3>Conclusions</h3><div>Social connectedness and perceived social support confer lasting protection against suicidal ideation. Clinicians should encourage preventive maintenance of diverse social networks in their middle-age and older patients/clients with depression and help them find adequate social support during acute suicidal crises.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100513"},"PeriodicalIF":4.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children","authors":"Kavari Hercules ,&nbsp;Zhiyuan Liu ,&nbsp;Eleni Christofilea ,&nbsp;Jia Wei ,&nbsp;Gladys Venegas ,&nbsp;Olivia Ciocca ,&nbsp;Alice Dyer ,&nbsp;Goeun Lee ,&nbsp;Sasha Santini-Bishop ,&nbsp;Heather Shappell ,&nbsp;Dylan G. Gee ,&nbsp;Denis G. Sukhodolsky ,&nbsp;Karim Ibrahim","doi":"10.1016/j.bpsgos.2025.100506","DOIUrl":"10.1016/j.bpsgos.2025.100506","url":null,"abstract":"<div><h3>Background</h3><div>It is unclear how transdiagnostic symptoms including attention, disruptive behavior, and internalizing problems are linked to in-scanner motion in children across structural and functional magnetic resonance imaging (fMRI). In the current study, we examined whether transdiagnostic symptoms of attention, disruptive behavior, and internalizing problems were associated with scanner motion in children during multimodal imaging.</div></div><div><h3>Methods</h3><div>In 9045 children ages 9 to 10 years in the ABCD (Adolescent Brain Cognitive Development) Study, logistic regression and linear mixed-effects models were used to examine associations between motion and behavior. Motion was indexed using ABCD Study quality control (QC) metrics and mean framewise displacement for T1- and T2-weighted structural, resting-state, and diffusion MRI; stop-signal task; monetary incentive delay task; and emotional n-back task. The Child Behavior Checklist was used as a continuous measure of symptom severity.</div></div><div><h3>Results</h3><div>Greater severity of attention and disruptive behavior problems was associated with a lower likelihood of passing motion QC across imaging modalities, while increased internalizing severity was associated with a higher likelihood of passing. There was also an interaction between sex and attention-related problems in passing QC for T2-weighted and diffusion MRI scans. Increased attention and disruptive behavior problems were associated with increased mean motion, whereas increased internalizing problems were associated with decreased mean motion. Greater severity of attention problems was associated with worse performance across the fMRI tasks.</div></div><div><h3>Conclusions</h3><div>These findings have implications for advancing the development of computational and behavioral approaches for mitigating motion effects in youths, enhancing accessibility of imaging protocols and representativeness influences across child psychiatric disorders, and identifying brain-based biomarkers.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100506"},"PeriodicalIF":4.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant Effects of Nitrous Oxide in Major Depressive Disorder: A Phase 2b Randomized Clinical Trial","authors":"Paul S. Myles ,&nbsp;Jayashri Kulkarni ,&nbsp;Jessica Kasza ,&nbsp;Sophie Wallace ,&nbsp;Carolyn Deng ,&nbsp;Alisa Turbić ,&nbsp;Verna Aykanat ,&nbsp;Charles R. Conway ,&nbsp;Frank Brown ,&nbsp;Royce Lee ,&nbsp;Robert D. Gibbons ,&nbsp;Peter Nagele","doi":"10.1016/j.bpsgos.2025.100504","DOIUrl":"10.1016/j.bpsgos.2025.100504","url":null,"abstract":"<div><h3>Background</h3><div>Nitrous oxide (“laughing gas”) is an NMDA receptor antagonist. In the current study, our aim was to investigate the efficacy, safety, and likely optimal dose of nitrous oxide in adults with major depressive disorder (MDD).</div></div><div><h3>Methods</h3><div>In this phase 2b randomized, double-blind trial, 81 patients with MDD were allocated on a 1:1 basis to receive nitrous oxide or oxygen/air (control); the nitrous group was further randomized to either 50% or 25% inspired nitrous oxide. All participants received four 1-hour-long treatment sessions at 1-week intervals and were followed for an additional 4 weeks. The primary outcome was the change in the 21-item Hamilton Depression Rating Scale (HAM-D) over the 4 treatment sessions. Secondary outcomes included remission (HAM-D ≤7 points), the Computerized Adaptive Test-Depression Inventory (CAT-DI) and Computerized Adaptive Test-Suicide Scale (CAT-SS).</div></div><div><h3>Results</h3><div>The mean averaged change in HAM-D scores over the 4 weeks of treatment was lower with nitrous oxide than with control (−1.9 [95% CI, −3.9 to 0.0], <em>p</em> = .051). In the first week, 15 of 39 (38%) in the nitrous oxide group and 5 of 39 (13%) in the control group were remitted (<em>p</em> = .031). The mean averaged change in CAT-DI scores was −7.7 (95% CI, −14.1 to −1.4), <em>p</em> = .017; the mean averaged change in CAT-SS scores was −8.3 (95% CI, −14.4 to −2.1), <em>p</em> = .008, both favoring nitrous oxide.</div></div><div><h3>Conclusions</h3><div>In this study, we confirmed that nitrous oxide has likely beneficial antidepressant effects in people with MDD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100504"},"PeriodicalIF":4.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}