Biological psychiatry global open science最新文献

{"title":"Comparing Data-Driven Subtypes of Depression Informed by Clinical and Neuroimaging Data: A Registered Report","authors":"Kayla Hannon ,&nbsp;Setthanan Jarukasemkit ,&nbsp;Leda Balogh ,&nbsp;Fyzeen Ahmad ,&nbsp;Petra Lenzini ,&nbsp;Aristeidis Sotiras ,&nbsp;Janine D. Bijsterbosch","doi":"10.1016/j.bpsgos.2025.100473","DOIUrl":"10.1016/j.bpsgos.2025.100473","url":null,"abstract":"<div><h3>Background</h3><div>Efforts to elucidate subtypes within depression have yet to establish a consensus. In this study, we aimed to rigorously compare different subtyping approaches in the same participant space to quantitatively test agreement across subtyping approaches and determine whether the different approaches are sensitive to different sources of heterogeneity in depression.</div></div><div><h3>Methods</h3><div>We implemented 6 different data-driven subtyping methods developed in previous work using the same UK Biobank participants (<em>n</em> = 2276 participants with depression, <em>n</em> = 1595 healthy control participants). The 6 approaches include 2 symptom-based, 2 structural neuroimaging–based, and 2 functional neuroimaging–based techniques. The resulting subtypes were compared based on participant assignment, stability, and sensitivity to subtype differences in demographics, general health, clinical characteristics, neuroimaging, trauma, cognition, genetics, and inflammation markers.</div></div><div><h3>Results</h3><div>We found almost no agreement between the resulting subtypes of the 6 approaches (mean adjusted Rand index [ARI] = 0.006), even within data domains. This finding was largely driven by differences in input feature set (mean ARI = 0.005) rather than clustering algorithm (mean ARI = 0.23). However, each approach had relatively high internal stability across bootstraps (ARI = 0.36–0.89); most approaches performed above null; and most approaches were sensitive to relevant phenotypes within their data domain.</div></div><div><h3>Conclusions</h3><div>Despite marginal overlap between approaches, we found the subtyping approaches to be internally consistent. These results explain why previous studies found strong evidence for subtypes within their analysis but with very little convergence between studies. We recommend that in future work, investigators incorporate systematic comparisons between their approach and alternative/previous approaches to facilitate consensus on depression subtypes.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100473"},"PeriodicalIF":4.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Frequency for Seizure Induction With Electroconvulsive Therapy and Magnetic Seizure Therapy in Nonhuman Primates","authors":"Angel V. Peterchev ,&nbsp;Zhi-De Deng ,&nbsp;Christopher Sikes-Keilp ,&nbsp;Elyssa C. Feuer ,&nbsp;Moacyr A. Rosa ,&nbsp;Sarah H. Lisanby","doi":"10.1016/j.bpsgos.2025.100471","DOIUrl":"10.1016/j.bpsgos.2025.100471","url":null,"abstract":"<div><h3>Background</h3><div>Electroconvulsive therapy (ECT) and magnetic seizure therapy (MST) are effective in the treatment of medication-resistant depression. Determining the stimulus frequency that results in the lowest seizure threshold could produce fewer adverse effects by reducing the overall stimulus intensity.</div></div><div><h3>Methods</h3><div>To determine the optimal frequency for seizure induction, 4 male rhesus macaques were titrated with an increasing number of pulses at fixed frequencies ranging from 5 to 240 pulses per second (pps) using ultrabrief pulse right-unilateral ECT and circular-coil-on-vertex MST. Bilateral electroencephalography was recorded to characterize the seizure expression.</div></div><div><h3>Results</h3><div>The seizure threshold dependence on stimulus frequency was similar for ECT and MST. While higher frequencies required progressively shorter trains to induce a seizure, the middle frequency range was associated with the fewest pulses (and therefore the least charge and energy), with a minimum at 16 pps and similarly low thresholds for 10 and 25 pps. The number of pulses at seizure threshold increased markedly at lower and higher frequencies. The lowest stimulus frequencies, 5 and 10 pps, were associated with the greatest ictal power measured by electroencephalography.</div></div><div><h3>Conclusions</h3><div>While neither efficacy nor side effects were assessed in this study, the results highlight the significance of stimulus frequency for seizure induction, suggest efficient titration schedules that minimize exposure to the electrical stimulus, and can inform studies to assess the impact on clinical outcomes. These data can also support safety guidelines for interventions such as transcranial magnetic stimulation that must avoid seizure induction.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100471"},"PeriodicalIF":4.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143696217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable White Matter Structure in the First Three Years After Psychosis Onset","authors":"Peter C. Van Dyken ,&nbsp;Kun Yang ,&nbsp;Andreia V. Faria ,&nbsp;Akira Sawa ,&nbsp;Michael MacKinley ,&nbsp;Ali R. Khan ,&nbsp;Lena Palaniyappan","doi":"10.1016/j.bpsgos.2025.100472","DOIUrl":"10.1016/j.bpsgos.2025.100472","url":null,"abstract":"<div><h3>Background</h3><div>White matter alterations observed using diffusion weighted imaging have become a hallmark of chronic schizophrenia, but it is unclear when these changes arise over the course of the disease. Nearly all studies reported to date have been cross-sectional, so despite their large sample sizes, they cannot determine whether changes accumulate as a degenerative process or patients with preexisting white matter damage are predisposed to more chronic forms of schizophrenia.</div></div><div><h3>Methods</h3><div>We examined 160 scans comprising 2 years of annual follow-up data from 42 control participants and 28 patients with schizophrenia recruited in the first 2 years since their diagnosis, totaling 2 to 3 scans per participant. We also examined 6-month follow-up data obtained from an ultra-high field (7T) scanner (68 scans; <em>n</em> = 19 patients with first-episode schizophrenia, <em>n</em> = 15 control participants) as a validation dataset. A longitudinal model was used to compare the trajectory of diffusion tensor parameters in patients and control participants.</div></div><div><h3>Results</h3><div>Positive and negative symptom scores were correlated with diffusion parameters using region of interest-based approaches. No longitudinal differences between patients and control participants were observed for any diffusion tensor imaging parameter in either dataset. However, we did observe consistent associations between white matter alterations and negative symptoms in both datasets.</div></div><div><h3>Conclusions</h3><div>White matter does not appear to be susceptible to schizophrenia-linked degeneration in the early stages of disease, but preexisting pathology may be linked to disease severity.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100472"},"PeriodicalIF":4.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Polygenic Risk Scores and Treatment Response to Antidepressants, Benzodiazepines, and Antihistamines in Anxiety and Depression","authors":"Amelie Markant ,&nbsp;Fara Tabrizi ,&nbsp;Hampus Grönvall ,&nbsp;Doug Speed ,&nbsp;Fredrik Åhs","doi":"10.1016/j.bpsgos.2025.100470","DOIUrl":"10.1016/j.bpsgos.2025.100470","url":null,"abstract":"<div><h3>Background</h3><div>Anxiety and depression are the most prevalent mental health disorders. The first-line treatment is antidepressants, such as serotonin reuptake inhibitors, but benzodiazepines and antihistamines are also used to treat anxiety. Only one-third of patients achieve remission with first-line treatment. Identifying responders and nonresponders to monotherapy prior to treatment could increase remission rates and reduce dropout. The aim of the current study was to predict response to antidepressants, benzodiazepines, and antihistamines from polygenic risk scores (PRSs) in individuals with anxiety and/or depression symptoms.</div></div><div><h3>Methods</h3><div>We identified 2515 individuals in a genotyped cohort in the Swedish Twin Registry who had been prescribed drugs for anxiety and/or depression. Of these individuals, 1037 received monotherapy (555 with antidepressants, 169 with benzodiazepines, and 313 with antihistamines). The remaining 1478 individuals switched or added more drugs during the assessment period (2005–2018). The accuracy of 42 PRSs for psychiatric diagnoses as well as for nonclinical phenotypes in predicting mono- versus multitherapy was assessed using logistic regression.</div></div><div><h3>Results</h3><div>Monotherapy with benzodiazepines was predicted by a PRS for depressive symptoms indexed by the Patient Health Questionnaire (odds ratio [OR] = 1.29), while monotherapy with antihistamines was predicted by a PRS for lifetime anxiety disorder (OR = 1.25) and a PRS for schizophrenia (OR = 1.24). None of the investigated PRSs significantly predicted monotherapy with antidepressants.</div></div><div><h3>Conclusions</h3><div>Real-world data suggest that monotherapy with benzodiazepines or antihistamines can be predicted from PRSs related to anxiety, depression, and schizophrenia.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100470"},"PeriodicalIF":4.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Processing in Autism Spectrum Disorder: The Atypical Iterative Prior Updating Account","authors":"Zhuanghua Shi ,&nbsp;Fredrik Allenmark ,&nbsp;Laura A. Theisinger ,&nbsp;Rasmus L. Pistorius ,&nbsp;Stefan Glasauer ,&nbsp;Hermann J. Müller ,&nbsp;Christine M. Falter-Wagner","doi":"10.1016/j.bpsgos.2025.100468","DOIUrl":"10.1016/j.bpsgos.2025.100468","url":null,"abstract":"<div><h3>Background</h3><div>The nature of predictive-processing differences between individuals with autism spectrum disorder (ASD) and typically developing (TD) individuals remains contested. Some studies have reported impaired predictive processing in ASD, while others have suggested intact but atypical learning dynamics.</div></div><div><h3>Methods</h3><div>We investigated duration reproduction tasks under high- and low-volatility settings to examine the updating dynamics of prior beliefs and sensory estimate updating in individuals with ASD (<em>n</em> = 32) and TD counterparts (<em>n</em> = 32). Using a two-state Bayesian model, we analyzed how the participants updated their prior beliefs and perceptual estimates and how these updates affected their behavior over time.</div></div><div><h3>Results</h3><div>Individuals with ASD integrated prior knowledge similarly to TD control participants for perceptual estimates. However, they relied more heavily on sensory input for iteratively updating their prior beliefs, perceiving events as less interconnected. This heightened reliance on sensory inputs led to the initial underweighting of priors in perceptual estimates, resulting in a weaker central tendency early in sessions. Over time, ASD participants adapted, reaching integration weights comparable to those of TD control participants by the end of the session. These findings suggest that predictive processing in ASD is characterized by distinct updating dynamics, not an inability to form or use prior effectively.</div></div><div><h3>Conclusions</h3><div>Our study highlights a unique interplay between sensory inputs and prior beliefs in ASD, where greater reliance on sensory inputs during prior updating influences adaptation speed and intertrial dynamics. This process clarifies inconsistencies in the literature and underscores the role of interactive updating in predictive processing differences between individuals with ASD and TD individuals.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100468"},"PeriodicalIF":4.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposome-Wide Gene-By-Environment Interaction Study of Psychotic Experiences in the UK Biobank","authors":"Bochao Danae Lin ,&nbsp;Lotta-Katrin Pries ,&nbsp;Angelo Arias-Magnasco ,&nbsp;Boris Klingenberg ,&nbsp;David E.J. Linden ,&nbsp;Gabriëlla A.M. Blokland ,&nbsp;Dennis van der Meer ,&nbsp;Jurjen J. Luykx ,&nbsp;Bart P.F. Rutten ,&nbsp;Sinan Guloksuz","doi":"10.1016/j.bpsgos.2025.100460","DOIUrl":"10.1016/j.bpsgos.2025.100460","url":null,"abstract":"<div><h3>Background</h3><div>A previous study successfully identified 148 of 23,098 exposures associated with any psychotic experiences (PEs) in the UK Biobank using an exposome-wide association study (XWAS). Furthermore, research has shown that the polygenic risk score for schizophrenia (PRS-SCZ) is associated with PEs. However, the interaction of these exposures with PRS-SCZ remains unknown.</div></div><div><h3>Method</h3><div>To systematically investigate possible gene-by-environment interactions underlying PEs through data-driven agnostic analyses, we conducted 1) conditional XWAS adjusting for PRS-SCZ to estimate the main effects of the exposures and of PRS-SCZ, 2) exposome-wide interaction study (XWIS) to estimate multiplicative and additive interactions between PRS-SCZ and exposures, and 3) correlation analyses between PRS-SCZ and exposures. The study included 148,502 participants from the UK Biobank.</div></div><div><h3>Results</h3><div>In the conditional XWAS models, significant effects of PRS-SCZ and 148 exposures on PEs remained statistically significant. In the XWIS model, we found significant multiplicative (multiplicative scale, 1.23; 95% CI, 1.10–1.37; <em>p</em> = 4.0 × 10⁻⁴) and additive (relative excess risk due to interaction, 0.55; 95% CI, 0.32–0.77; synergy index, 0.22; 95% CI, 0.14–0.30; and attributable proportion, 1.59; 95% CI, 1.30–1.91; all <em>p</em>s &lt; .05/148) interactions of PRS-SCZ and the variable serious medical conditions/disability with PEs. We additionally identified 6 additive gene-by-environment interactions for mental distress, help-/treatment-seeking behaviors (3 variables), sadness, and sleep problems. In the correlation test focused on 7 exposures that exhibited significant interactions with PRS-SCZ, nonsignificant or small (<em>r</em> &lt; 0.04) gene-by-environment correlations were observed.</div></div><div><h3>Conclusions</h3><div>These findings reveal evidence for gene-by-environment interactions underlying PEs and suggest that intertwined pathways of genetic vulnerability and exposures may contribute to psychosis risk.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100460"},"PeriodicalIF":4.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Variations in Daily Cortisol Pattern and Long-Term Cortisol Output on Hippocampal Subfield Volumes in the Adult Human Brain","authors":"Nikolai Malykhin ,&nbsp;Joseph Serrano ,&nbsp;Béla Reiz ,&nbsp;Kathleen Hegadoren ,&nbsp;Wojciech Pietrasik ,&nbsp;Randy Whittal","doi":"10.1016/j.bpsgos.2025.100458","DOIUrl":"10.1016/j.bpsgos.2025.100458","url":null,"abstract":"<div><h3>Background</h3><div>Animal models of adult chronic stress indicate that the cornu ammonis 1–3 (CA1–3) and dentate gyrus (DG) hippocampal subfields are most susceptible to cellular changes associated with prolonged psychogenic stressors and glucocorticoid overexposure. However, no study reported to date has examined associations between long-term cortisol output, chronic stress, and hippocampal subfield volumes in healthy adults experiencing different levels of chronic stress. The main goal of the current study was to test whether higher long-term cortisol output measured by hair cortisol concentration would be associated with atrophy of CA1–3 and DG hippocampal subfields.</div></div><div><h3>Methods</h3><div>We examined associations between short- and long-term cortisol output and hippocampal subfield volumes in healthy adults (<em>N</em> = 40). High-resolution structural magnetic resonance imaging datasets were acquired together with diurnal salivary cortisol and hair cortisol measures. Hair cortisol concentration was analyzed using the high-resolution liquid chromatography–mass spectrometry method.</div></div><div><h3>Results</h3><div>Higher hair cortisol concentration was associated with smaller volumes of all hippocampal subfields in the anterior hippocampus and smaller DG volumes in both the anterior and posterior hippocampus. We found that a larger increase in morning cortisol level after awakening was associated with smaller DG and CA1–3 volumes, while a smaller decrease in cortisol level in the afternoon from awakening was associated with smaller CA1–3 volume in the anterior hippocampus. The observed associations between cortisol and hippocampal subfield volumes were not predicted by individual chronic stress levels or history of childhood trauma.</div></div><div><h3>Conclusions</h3><div>Our results suggest that both increased hair cortisol concentration and daily cortisol fluctuations can have a negative impact on the CA1–3 and DG subfields.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100458"},"PeriodicalIF":4.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigative Approaches to Resilient Emotion Regulation Neurodevelopment in a South African Birth Cohort","authors":"Tristan Yates ,&nbsp;Siphumelele Sigwebela ,&nbsp;Soraya Seedat ,&nbsp;Michael Milham ,&nbsp;Stefan du Plessis ,&nbsp;Lior Abramson ,&nbsp;Erica Niemiec ,&nbsp;Carol Worthman ,&nbsp;Mary Jane Rotheram-Borus ,&nbsp;Giovanni Salum ,&nbsp;Alexandre Franco ,&nbsp;Arianna Zuanazzi ,&nbsp;Fatima Ahmed ,&nbsp;Kelly Gemmell ,&nbsp;Joan Christodoulou ,&nbsp;Nomandla Mhlaba ,&nbsp;Noluncedo Mqhele ,&nbsp;Nomfusi Ngalimane ,&nbsp;Akhona Sambudla ,&nbsp;Nim Tottenham ,&nbsp;Mark Tomlinson","doi":"10.1016/j.bpsgos.2025.100457","DOIUrl":"10.1016/j.bpsgos.2025.100457","url":null,"abstract":"<div><div>Understanding the neurobiology of resilient emotion regulation following adversities is critical for addressing mental health problems globally. However, the functional neurobiology of resilience has rarely been studied in low- and middle-income countries, which comprise 90% of the world’s population and experience more consistent adversities. Here, we describe how we are investigating the neurodevelopment of resilient emotion regulation in adolescents (anticipated <em>N</em> = 525) from a South African birth cohort recruited from a low-income, high-adversity township. Across 2 longitudinal time points (13–14 and 15–16 years), magnetic resonance imaging, behavior, and self-report measures from adolescents and their caregivers are collected. These data are complemented by existing developmental histories (from the prenatal period to 8 years). The culturally adapted measures, protocols, and analytic plans for investigating resilient emotion regulation are presented. By characterizing neurodevelopmental correlates of adolescent resilience from an understudied low- and middle-income country, this research will provide deeper insights into mental health globally.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100457"},"PeriodicalIF":4.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diminished Social Memory and Hippocampal Correlates of Social Interactions in Chronic Social Defeat Stress Susceptibility","authors":"Amanda Larosa ,&nbsp;Tian Rui Zhang ,&nbsp;Alice S. Wong ,&nbsp;Cyrus Y.H. Fung ,&nbsp;Xiong Ling Yun (Jenny) Long ,&nbsp;Prabhjeet Singh ,&nbsp;Benjamin C.M. Fung ,&nbsp;Tak Pan Wong","doi":"10.1016/j.bpsgos.2025.100455","DOIUrl":"10.1016/j.bpsgos.2025.100455","url":null,"abstract":"<div><h3>Background</h3><div>Susceptibility to chronic stress has been associated with depression, a mood disorder that highly implicates the hippocampus. Hippocampal contribution to stress susceptibility has been supported by findings in mice following chronic social defeat stress (CSDS). However, little is known about the role of hippocampal activity in determining the development of stress susceptibility.</div></div><div><h3>Methods</h3><div>We used the UCLA Miniscope to longitudinally measure the activity of dorsal CA1 hippocampal neurons during CSDS. In addition to examining the representation of social information by these neurons, we compared social memory in mice that were either susceptible or resilient to CSDS.</div></div><div><h3>Results</h3><div>We observed more stable dorsal CA1 correlates of social interaction and social memory in CSDS-resilient mice. Such changes were absent in CSDS-susceptible mice and accompanied by greater social memory impairments.</div></div><div><h3>Conclusions</h3><div>CSDS susceptibility may be supported by hippocampal social cognitive processes, as reflected in diminished hippocampal representations of social information and greater impairment in social memory in suspectible compared with resilient mice.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100455"},"PeriodicalIF":4.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Microbiome in Relation to Mental Distress Across Two Points During Pregnancy: Data From U.S. and Swedish Cohorts","authors":"Mary Kimmel ,&nbsp;Bangzhuo Tong ,&nbsp;Alfons Edbom Devall ,&nbsp;Richelle D. Björvang ,&nbsp;Ina Schuppe-Koistinen ,&nbsp;Lars Engstrand ,&nbsp;Emma Fransson ,&nbsp;Alkistis Skalkidou ,&nbsp;Luisa W. Hugerth","doi":"10.1016/j.bpsgos.2025.100453","DOIUrl":"10.1016/j.bpsgos.2025.100453","url":null,"abstract":"<div><h3>Background</h3><div>In this study, we aimed to characterize the gut microbiome and its potential functioning in 2 populations at 2 time points during pregnancy in relation to mental distress.</div></div><div><h3>Methods</h3><div>During the second and third trimester, individuals from the United States and Sweden completed the Edinburgh Postnatal Depression Scale and provided fecal samples for whole-genome metagenomics. A total of 832 and 161 samples were sequenced and analyzed from the Swedish cohort and the U.S. cohort, respectively. Multiple characterizations of the microbial community were analyzed in relation to distress measured using the Edinburgh Postnatal Depression Scale. Principal coordinate analysis and distance-based redundancy analysis assessed variation in functional gut-brain modules. For the U.S. cohort, the Trier Social Stress Test was administered 8 weeks postpartum while collecting salivary cortisol.</div></div><div><h3>Results</h3><div>Principal coordinate analysis identified 4 sample clusters based on the gut-brain modules distinguished by functions such as short-chain fatty acid synthesis and cortisol degradation. While with distance-based redundancy analysis, mental distress subtypes did not significantly contribute to variation in gut-brain modules (<em>p</em> = .085 for Sweden, <em>p</em> = .23 for the U.S.), a U.S. sample cluster distinguished by lower cortisol degradation from another cluster with higher gut microbial cortisol degradation abundance had significantly higher odds of being associated with depression (<em>p</em> = .024). The U.S. sample cluster with lower gut microbial cortisol degradation abundance also had significantly higher cortisol levels after a postpartum social stressor.</div></div><div><h3>Conclusions</h3><div>Further studies are warranted to investigate the potential for the gut microbiome to serve as biomarkers of gut-brain axis health during pregnancy across disparate populations.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100453"},"PeriodicalIF":4.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}