Biological psychiatry global open science最新文献_第2页

Embracing Model Heterogeneity for Better Brain-Behavior Associations

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Biological psychiatry global open science Pub Date : 2025-01-01 DOI: 10.1016/j.bpsgos.2024.100425

Dustin Scheinost , Marisa N. Spann

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Multidimensional Effects of Stress on Neuronal Exosome Levels and Simultaneous Transcriptomic Profiles 应激对神经元外泌体水平和同步转录组谱的多维影响。

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Biological psychiatry global open science Pub Date : 2025-01-01 DOI: 10.1016/j.bpsgos.2024.100401

Hope Kronman , Amarjyot Singh , Shofiul Azam , Andrea S. Guzman , Danielle Zelli , Timothy Lau , Josh Dobbin , Benedetta Bigio , Carla Nasca

{"title":"Multidimensional Effects of Stress on Neuronal Exosome Levels and Simultaneous Transcriptomic Profiles","authors":"Hope Kronman , Amarjyot Singh , Shofiul Azam , Andrea S. Guzman , Danielle Zelli , Timothy Lau , Josh Dobbin , Benedetta Bigio , Carla Nasca","doi":"10.1016/j.bpsgos.2024.100401","DOIUrl":"10.1016/j.bpsgos.2024.100401","url":null,"abstract":"<div><h3>Background</h3><div>An excess of exosomes, nanovesicles released from all cells and key regulators of brain plasticity, is an emerging therapeutic target for stress-related mental illnesses. The effects of chronic stress on exosome levels are unknown; even less is known about molecular drivers of exosome levels in the stress response.</div></div><div><h3>Methods</h3><div>We used our state-of-the-art protocol with 2 complementary strategies to isolate neuronal exosomes from plasma, ventral dentate gyrus, basolateral amygdala, and olfactory bulbs of male mice to determine the effects of chronic restraint stress (CRS) on exosome levels. Next, we used RNA sequencing and bioinformatic analyses to identify molecular drivers of exosome levels.</div></div><div><h3>Results</h3><div>We found that CRS leads to an increase in the levels of neuronal exosomes but not total (i.e., not neuronally enriched) exosome levels assayed in plasma and the ventral dentate gyrus, whereas CRS leads to a decrease in neuronal exosome levels but not total exosome levels in the basolateral amygdala. There was a further specificity of effects as shown by a lack of changes in the levels of neuronal exosomes assayed in the olfactory bulbs. In pursuit of advancing translational applications, we showed that acetyl-L-carnitine administration restores the CRS-induced increase in neuronal exosome levels assayed in plasma (the most accessible specimen). Furthermore, the CRS-induced changes in neuronal exosome levels in the ventral dentate gyrus and basolateral amygdala mirrored the opposite pattern of CRS-induced transcriptional changes in these key brain areas, with β-estradiol signaling as a potential upstream driver of neuronal exosome levels.</div></div><div><h3>Conclusions</h3><div>This study provides a foundation for future studies of new forms of local and distant communication in stress neurobiology by demonstrating specific relationships between neuronal exosome levels assayed in plasma and the brain and providing new candidate targets for the normalization of exosome levels.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100401"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Delineating Adaptive and Maladaptive Outcomes of Aggression in Mice

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Biological psychiatry global open science Pub Date : 2025-01-01 DOI: 10.1016/j.bpsgos.2024.100418

Barbara Benowitz, Meghan Flanigan

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In This Issue – January 2025

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Biological psychiatry global open science Pub Date : 2025-01-01 DOI: 10.1016/j.bpsgos.2024.100433

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Stress System Concordance: A Signature of Resilience

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Biological psychiatry global open science Pub Date : 2025-01-01 DOI: 10.1016/j.bpsgos.2024.100427

E. Ronald de Kloet , Marc L. Molendijk

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Editorial Board Page

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Biological psychiatry global open science Pub Date : 2025-01-01 DOI: 10.1016/S2667-1743(24)00152-6

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Differences in Head Motion During Functional Magnetic Resonance Imaging Across Pediatric Neuropsychiatric Disorders

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Biological psychiatry global open science Pub Date : 2024-12-27 DOI: 10.1016/j.bpsgos.2024.100446

Tracey C. Shi , Katherine Durham , Rachel Marsh , David Pagliaccio

{"title":"Differences in Head Motion During Functional Magnetic Resonance Imaging Across Pediatric Neuropsychiatric Disorders","authors":"Tracey C. Shi , Katherine Durham , Rachel Marsh , David Pagliaccio","doi":"10.1016/j.bpsgos.2024.100446","DOIUrl":"10.1016/j.bpsgos.2024.100446","url":null,"abstract":"<div><h3>Background</h3><div>Robust correction for head motion during functional magnetic resonance imaging is critical to avoid artifact-driven findings. Despite head motion differences across neuropsychiatric disorders, pediatric head motion across a range of diagnoses and covariates has not yet been evaluated. We tested 4 preregistered hypotheses: 1) externalizing disorder diagnoses will associate with more head motion during scanning; 2) internalizing disorder diagnoses will associate with less motion; 3) among children without attention-deficit/hyperactivity disorder, externalizing disorders will associate with more motion; and 4) among children with attention-deficit/hyperactivity disorder, comorbid internalizing disorders will associate with less motion.</div></div><div><h3>Methods</h3><div>Healthy Brain Network data releases 1.0–7.0 (<em>n</em> = 971) were analyzed in a discovery phase, and additional data released by February 29, 2024 (<em>n</em> = 437) were used in confirmatory analyses. Linear mixed-effects models were fitted with in-scanner head motion as the dependent variable. Binary independent variables of interest assessed for the presence or absence of externalizing or internalizing disorders.</div></div><div><h3>Results</h3><div>The confirmatory sample did not show significant associations between head motion and externalizing or internalizing disorders or support for the preregistered hypotheses. Across samples, there was a consistent interaction between age and neurodevelopmental diagnoses such that age-related decreases in head motion were attenuated in children with neurodevelopmental disorders.</div></div><div><h3>Conclusions</h3><div>Head motion remains an important confound in pediatric neuroimaging that may be associated with many factors, including neuropsychiatric symptoms, age, cognitive and physical attributes, and interactions among these variables. This work takes a step toward parsing these complex associations, focusing on neuropsychiatric diagnoses, age, and their interaction.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100446"},"PeriodicalIF":4.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Pathophysiological Models of Hypersomnolence Associated With Depression

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Biological psychiatry global open science Pub Date : 2024-12-26 DOI: 10.1016/j.bpsgos.2024.100445

Christophe Moderie, Diane B. Boivin

{"title":"Pathophysiological Models of Hypersomnolence Associated With Depression","authors":"Christophe Moderie, Diane B. Boivin","doi":"10.1016/j.bpsgos.2024.100445","DOIUrl":"10.1016/j.bpsgos.2024.100445","url":null,"abstract":"<div><div>Up to 25% of patients with depression experience hypersomnolence (e.g., excessive daytime sleepiness, hypersomnia, and/or sleep inertia), which is associated with treatment resistance, overall poorer outcomes, and safety concerns while driving. Hypersomnolence can result from various sleep/neurological disorders or side effects from medication but is often medically unexplained in depression. In this review, we aimed to summarize the different pathophysiological models of hypersomnolence in depression to discuss their impact on nosology and to foster the development of better tailored diagnostics and treatments. We identified several potential mechanisms underlying hypersomnolence including a daytime hypoactivity of dopaminergic and noradrenergic systems, nighttime GABA (gamma-aminobutyric acid) hypoactivation, hypoperfusion, and hypoconnectivity in the medial prefrontal cortex, as well as a longer circadian period and light hyposensitivity. In some patients with depression, nighttime hyperarousal can fragment sleep and result in a complaint of excessive daytime sleepiness, thus mimicking hypersomnolence. Others might adopt maladaptive behaviors such as spending excessive time in bed, a term coined clinophilia. Objective markers of hypersomnolence, such as ambulatory ad libitum polysomnography may facilitate distinguishing between conditions that mimic hypersomnolence. Our review identified several clinical targets for hypersomnolence in depression. Low-sodium oxybate, which is approved for idiopathic hypersomnia, needs additional study in patients with depression. Neuromodulation that targets prefrontal cortex anomalies should be systematically explored, while tailored light therapy protocols may mitigate light hyposensitivity. Additionally, cognitive behavioral therapy for hypersomnolence is being developed as a nonpharmacological adjunct to these treatments.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100445"},"PeriodicalIF":4.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental Health Across the Metabolic Spectrum

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Biological psychiatry global open science Pub Date : 2024-12-20 DOI: 10.1016/j.bpsgos.2024.100443

Vrinda Saxena , Isaac Marin-Valencia

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Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents

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Biological psychiatry global open science Pub Date : 2024-12-19 DOI: 10.1016/j.bpsgos.2024.100435

Frank Mazza , Alexandre Guet-McCreight , Thomas D. Prevot , Taufik Valiante , Etienne Sibille , Etay Hay

{"title":"Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents","authors":"Frank Mazza , Alexandre Guet-McCreight , Thomas D. Prevot , Taufik Valiante , Etienne Sibille , Etay Hay","doi":"10.1016/j.bpsgos.2024.100435","DOIUrl":"10.1016/j.bpsgos.2024.100435","url":null,"abstract":"<div><h3>Background</h3><div>Reduced cortical inhibition mediated by GABA (gamma-aminobutyric acid) is reported in depression, anxiety disorders, and aging. A novel positive allosteric modulator that specifically targets the α5-GABA<sub>A</sub> receptor subunit (α5-PAM), ligand GL-II-73 shows anxiolytic, antidepressant, and procognitive effects without the common side effects associated with nonspecific modulation by benzodiazepines such as diazepam, thus suggesting novel therapeutic potential. However, it is unknown whether α5-PAM has detectable signatures in clinically relevant brain electroencephalography (EEG).</div></div><div><h3>Methods</h3><div>We analyzed EEG in 10 freely moving rats at baseline and following injections of α5-PAM (GL-II-73) and diazepam.</div></div><div><h3>Results</h3><div>We showed that α5-PAM specifically decreased theta peak power, whereas diazepam shifted peak power from high to low theta while increasing beta and gamma power. EEG decomposition showed that these effects were periodic and corresponded to changes in theta oscillation event duration.</div></div><div><h3>Conclusions</h3><div>Thus, our study shows that α5-PAM has robust and distinct EEG biomarkers in rodents, indicating that EEG could enable noninvasive monitoring of α5-PAM treatment efficacy.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100435"},"PeriodicalIF":4.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0