Biological psychiatry global open science最新文献

{"title":"Cross-Species Evidence for Psilocin-Induced Visual Distortions: Apparent Motion Is Perceived by Both Humans and Rats","authors":"Čestmír Vejmola ,&nbsp;Klára Šíchová ,&nbsp;Kateřina Syrová ,&nbsp;Lucie Janečková ,&nbsp;Vlastimil Koudelka ,&nbsp;Michael Tesař ,&nbsp;Marek Nikolič ,&nbsp;Michaela Viktorinová ,&nbsp;Filip Tylš ,&nbsp;Jakub Korčák ,&nbsp;Vojtěch Viktorin ,&nbsp;Eduard Kelemen ,&nbsp;Tereza Nekovářová ,&nbsp;Martin Brunovský ,&nbsp;Jiří Horáček ,&nbsp;Martin Kuchař ,&nbsp;Tomáš Páleníček","doi":"10.1016/j.bpsgos.2025.100524","DOIUrl":"10.1016/j.bpsgos.2025.100524","url":null,"abstract":"<div><h3>Background</h3><div>Psychedelics, particularly psilocin, are increasingly being studied for their mind-altering effects and potential therapeutic applications in psychiatry. Visual hallucinations, especially the illusion of motion in static images, are a hallmark of their action. Despite growing interest, the underlying mechanisms remain poorly understood, as their systematic evaluation in both humans and animals is challenging.</div></div><div><h3>Methods</h3><div>To investigate psilocin-induced visual distortions, we designed a 2-choice visual discrimination task. Human participants and male rats indicated whether an image appeared static or moving while the image either actually moved or did not. In humans, performance was compared with self-reported hallucination intensity, Altered States of Consciousness scale scores, and psilocin plasma levels. Rats were tested in 2 distinct tasks, a luminance-based task and a motion-based task. Their performance was evaluated alongside decision time.</div></div><div><h3>Results</h3><div>Both species exhibited significant impairment in distinguishing static from dynamic visual stimuli while under psilocin’s influence. In humans, this impairment followed the time course of psilocin plasma levels and hallucination intensity. In rats, psilocin selectively impaired performance in the motion-based task, while performance in the luminance-based task remained intact, indicating a specific effect on visual perception. Decision time was linked to discrimination impairment.</div></div><div><h3>Conclusions</h3><div>Psilocin impaired static-dynamic discrimination in both species, providing the first evidence that rats experience visual distortions similar to those reported by humans. The correlations between discrimination impairment, psilocin levels, and hallucination intensity in humans reinforce psilocin’s effects on visual perception. This approach provides a valuable tool for investigating the neurobiology of altered visual perception in drug-induced states and psychiatric conditions.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100524"},"PeriodicalIF":4.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divergent Longitudinal Trajectories and Neurotransmitter Associations of Striatal Subparcellation Spontaneous Activity in Major Depressive Disorder","authors":"Zhenxiang Zang ,&nbsp;Kaini Qiao ,&nbsp;Xiongying Chen ,&nbsp;Jing Jing Zhou ,&nbsp;Zhi Yang ,&nbsp;Gang Wang","doi":"10.1016/j.bpsgos.2025.100523","DOIUrl":"10.1016/j.bpsgos.2025.100523","url":null,"abstract":"<div><h3>Background</h3><div>The striatum, which anatomically comprises the putamen, caudate, and nucleus accumbens (NAc), is a key region implicated in major depressive disorder (MDD). However, whether the abnormal spontaneous activity of these subparcellations exhibits universal or distinct characteristics remains unclear.</div></div><div><h3>Methods</h3><div>In this study, we analyzed the amplitude of low-frequency fluctuations as an indicator of spontaneous activity from resting-state functional magnetic resonance imaging in 1832 individuals from 2 independent cohorts.</div></div><div><h3>Results</h3><div>Patients with MDD demonstrated consistent hyperactivity in the putamen and NAc (Cohen’s <em>d</em> = 0.29–0.34). Striatal hyperactivity was not different in patients with first-episode and recurrent MDD. There was no robust correlation between striatal hyperactivity and Hamilton Depression Rating Scale scores. Only the putamen’s hyperactivity could be normalized through ordinary antidepressant treatment. Hyperactivity in the putamen was correlated with both serotonin and dopamine neurotransmitter profiles, while NAc hyperactivity was correlated with serotonin profiles.</div></div><div><h3>Conclusions</h3><div>Spontaneous hyperactivity in the putamen and NAc are reproducible functional imaging markers of MDD. While the hyperactivity of the putamen was responsive to antidepressant treatment, the hyperactivity of the NAc was more trait like. In conclusion, our study revealed both common and divergent spontaneous activity characteristics of the striatum subparcellations in patients with MDD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100523"},"PeriodicalIF":4.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating Role of Trauma Connecting Psychiatric Family History and Adolescent Mental Health","authors":"Barbara H. Chaiyachati ,&nbsp;Jamie L. Catalano ,&nbsp;Laura M. Schultz ,&nbsp;Laura Almasy ,&nbsp;Elina Visoki ,&nbsp;Jakob Seidlitz ,&nbsp;Tyler M. Moore ,&nbsp;Jerome H. Taylor ,&nbsp;Monica E. Calkins ,&nbsp;Raquel E. Gur ,&nbsp;Ran Barzilay","doi":"10.1016/j.bpsgos.2025.100525","DOIUrl":"10.1016/j.bpsgos.2025.100525","url":null,"abstract":"<div><h3>Background</h3><div>Adolescent mental health is influenced by family history. Experiences of trauma also convey substantial risk for mental health challenges. Mediation of the association of family history with adolescent mental health by trauma experiences could be actionable and warrants evaluation. We sought to interrogate the mediating role of trauma in the association of family history of psychiatric disorders (FH) with adolescent general psychopathology, accounting for shared environment and genetics.</div></div><div><h3>Methods</h3><div>The Philadelphia Neurodevelopmental Cohort was a cross-sectional study of participants ages 8 to 21 years with English fluency and in good medical health with characterization from November 2009 to December 2011. The analysis reported here was completed from March 2023 to February 2025. Among 7840 participants, we tested associations of first-degree FH (category count [0–4]: psychosis, mood, suicide attempt, substance use), youth exposure to trauma, neighborhood environment (block-level geocoded socioeconomic indices), and genomic factor of polygenic scores for psychopathologies (depression, posttraumatic stress disorder, schizophrenia, bipolar, cross-disorder) with adolescent general psychopathology modeled as p-factor. Association of FH with general psychopathology was assessed with structural equation modeling, querying for an indirect pathway via trauma, with stepwise accounting of genomics and shared environment, controlling for age and sex.</div></div><div><h3>Results</h3><div>Of 7840 participants, 31% had FH and 44% of youths reported trauma exposure. Trauma had substantial direct association with general psychopathology and consistently mediated more than 20% of variance from FH to psychopathology, accounting for neighborhood and genomic predisposition.</div></div><div><h3>Conclusions</h3><div>Trauma exposures mediate a substantial portion of association between FH and adolescent psychopathology, an opportunity for transgenerational intervention.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100525"},"PeriodicalIF":4.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverting the Dominant Paradigm: Looking for Psychiatric Disorders in People With Metabolic Diseases","authors":"Judith M. Ford","doi":"10.1016/j.bpsgos.2025.100469","DOIUrl":"10.1016/j.bpsgos.2025.100469","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100469"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights From the Postmortem Transcriptome of a Geriatric Population With Depressive Symptoms","authors":"Anjali Chawla,&nbsp;Gustavo Turecki","doi":"10.1016/j.bpsgos.2025.100493","DOIUrl":"10.1016/j.bpsgos.2025.100493","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100493"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S2667-1743(25)00063-1","DOIUrl":"10.1016/S2667-1743(25)00063-1","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100509"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing the Elephant: The Search for Electroencephalography Biomarkers","authors":"Sydney E. Smith","doi":"10.1016/j.bpsgos.2025.100459","DOIUrl":"10.1016/j.bpsgos.2025.100459","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100459"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2667-1743(25)00065-5","DOIUrl":"10.1016/S2667-1743(25)00065-5","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100511"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction to the Special Issue on Mindfulness: Measurement, Methods, Mechanisms, & Mental Health","authors":"Todd S. Braver ,&nbsp;Sara W. Lazar","doi":"10.1016/j.bpsgos.2025.100475","DOIUrl":"10.1016/j.bpsgos.2025.100475","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100475"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2667-1743(25)00062-X","DOIUrl":"10.1016/S2667-1743(25)00062-X","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100508"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}