Biological psychiatry global open science最新文献

{"title":"MEF2C Hypofunction in GABAergic Cells Alters Sociability and Prefrontal Cortex Inhibitory Synaptic Transmission in a Sex-Dependent Manner","authors":"Jennifer Y. Cho ,&nbsp;Jeffrey A. Rumschlag ,&nbsp;Evgeny Tsvetkov ,&nbsp;Divya S. Proper ,&nbsp;Hainan Lang ,&nbsp;Stefano Berto ,&nbsp;Ahlem Assali ,&nbsp;Christopher W. Cowan","doi":"10.1016/j.bpsgos.2024.100289","DOIUrl":"10.1016/j.bpsgos.2024.100289","url":null,"abstract":"<div><h3>Background</h3><p>Heterozygous mutations or deletions of <em>MEF2C</em> cause a neurodevelopmental disorder termed MEF2C haploinsufficiency syndrome (MCHS), characterized by autism spectrum disorder and neurological symptoms. In mice, global <em>Mef2c</em> heterozygosity has produced multiple MCHS-like phenotypes. MEF2C is highly expressed in multiple cell types of the developing brain, including GABAergic (gamma-aminobutyric acidergic) inhibitory neurons, but the influence of MEF2C hypofunction in GABAergic neurons on MCHS-like phenotypes remains unclear.</p></div><div><h3>Methods</h3><p>We employed GABAergic cell type–specific manipulations to study mouse <em>Mef2c</em> heterozygosity in a battery of MCHS-like behaviors. We also performed electroencephalography, single-cell transcriptomics, and patch-clamp electrophysiology and optogenetics to assess the impact of <em>Mef2c</em> haploinsufficiency on gene expression and prefrontal cortex microcircuits.</p></div><div><h3>Results</h3><p><em>Mef2c</em> heterozygosity in developing GABAergic cells produced female-specific deficits in social preference and altered approach-avoidance behavior. In female, but not male, mice, we observed that <em>Mef2c</em> heterozygosity in developing GABAergic cells produced 1) differentially expressed genes in multiple cell types, including parvalbumin-expressing GABAergic neurons, 2) baseline and social-related frontocortical network activity alterations, and 3) reductions in parvalbumin cell intrinsic excitability and inhibitory synaptic transmission onto deep-layer pyramidal neurons.</p></div><div><h3>Conclusions</h3><p>MEF2C hypofunction in female, but not male, developing GABAergic cells is important for typical sociability and approach-avoidance behaviors and normal parvalbumin inhibitory neuron function in the prefrontal cortex of mice. While there is no apparent sex bias in autism spectrum disorder symptoms of MCHS, our findings suggest that GABAergic cell-specific dysfunction in females with MCHS may contribute disproportionately to sociability symptoms.</p></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000028/pdfft?md5=caf06d8bece048e0e6b00922c4e69a83&pid=1-s2.0-S2667174324000028-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139633431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling Sex Differences in Affect Processing: Unique Oscillatory Signaling Dynamics in the Infralimbic Cortex and Nucleus Accumbens Shell","authors":"Joaquin E. Douton,&nbsp;Regina M. Carelli","doi":"10.1016/j.bpsgos.2023.08.011","DOIUrl":"10.1016/j.bpsgos.2023.08.011","url":null,"abstract":"<div><h3>Background</h3><p>Negative affect is prevalent in psychiatric diseases such as depression and addiction. Projections from the infralimbic cortex (IL) to the nucleus accumbens shell (NAcSh) are causally linked to learned negative affect as 20 Hz optogenetic stimulation of this circuit reduces conditioned taste aversion (CTA) in male but not female rats. However, the prior study did not provide insight into how innate versus learned negative affect are processed in these areas across sex.</p></div><div><h3>Methods</h3><p>To address this issue, local field potential activity was simultaneously recorded in the IL and NAcSh in response to intraoral infusion of rewarding (saccharin) and aversive (quinine) tastants and following induction of a CTA in male and female Sprague Dawley rats.</p></div><div><h3>Results</h3><p>Local field potential oscillatory activity within each brain region to saccharin varied across sex. In males, CTA increased IL resting-state power, which was correlated with the strength of the learned aversion, and reduced beta power and IL-NAcSh coherence. In females, CTA increased gamma power in the NAcSh. Similar effects were observed in males and females after CTA in theta-low gamma phase-amplitude coupling. Finally, while quinine produced similar effects in oscillatory power across sex, females showed differences in phase-amplitude coupling within the NAcSh that may be linked to aversion resistance.</p></div><div><h3>Conclusions</h3><p>We revealed sex-specific hedonic processing in the IL and NAcSh and how oscillatory signaling is disrupted in learned negative affect, revealing translationally relevant insight into potential treatment strategies that can help to reduce the deleterious effects of learned negative affect in psychiatric illnesses.</p></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174323001015/pdfft?md5=815ecb39c269d58f412b7a0e5ef7e864&pid=1-s2.0-S2667174323001015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44762405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Evidence Supporting an Effect of Prenatal Cannabis Exposure on White Matter Integrity","authors":"David A.A. Baranger","doi":"10.1016/j.bpsgos.2023.11.002","DOIUrl":"https://doi.org/10.1016/j.bpsgos.2023.11.002","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174323001453/pdfft?md5=055fc1ee440d7c7e4b4c3ce55e2fb117&pid=1-s2.0-S2667174323001453-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139473535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrusive Traumatic Re-Experiencing Domain: Functional Connectivity Feature Classification by the ENIGMA PTSD Consortium","authors":"Benjamin Suarez-Jimenez ,&nbsp;Amit Lazarov ,&nbsp;Xi Zhu ,&nbsp;Sigal Zilcha-Mano ,&nbsp;Yoojean Kim ,&nbsp;Claire E. Marino ,&nbsp;Pavel Rjabtsenkov ,&nbsp;Shreya Y. Bavdekar ,&nbsp;Daniel S. Pine ,&nbsp;Yair Bar-Haim ,&nbsp;Christine L. Larson ,&nbsp;Ashley A. Huggins ,&nbsp;Terri deRoon-Cassini ,&nbsp;Carissa Tomas ,&nbsp;Jacklynn Fitzgerald ,&nbsp;Mitzy Kennis ,&nbsp;Tim Varkevisser ,&nbsp;Elbert Geuze ,&nbsp;Yann Quidé ,&nbsp;Wissam El Hage ,&nbsp;Rajendra A. Morey","doi":"10.1016/j.bpsgos.2023.05.006","DOIUrl":"10.1016/j.bpsgos.2023.05.006","url":null,"abstract":"<div><h3>Background</h3><p>Intrusive traumatic re-experiencing domain (ITRED) was recently introduced as a novel perspective on posttraumatic psychopathology, proposing to focus research of posttraumatic stress disorder (PTSD) on the unique symptoms of intrusive and involuntary re-experiencing of the trauma, namely, intrusive memories, nightmares, and flashbacks. The aim of the present study was to explore ITRED from a neural network connectivity perspective.</p></div><div><h3>Methods</h3><p>Data were collected from 9 sites taking part in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) PTSD Consortium (<em>n</em> <em>=</em> 584) and included itemized PTSD symptom scores and resting-state functional connectivity (rsFC) data. We assessed the utility of rsFC in classifying PTSD, ITRED-only (no PTSD diagnosis), and trauma-exposed (TE)–only (no PTSD or ITRED) groups using a machine learning approach, examining well-known networks implicated in PTSD. A random forest classification model was built on a training set using cross-validation, and the averaged cross-validation model performance for classification was evaluated using the area under the curve. The model was tested using a fully independent portion of the data (test dataset), and the test area under the curve was evaluated.</p></div><div><h3>Results</h3><p>rsFC signatures differentiated TE-only participants from PTSD and ITRED-only participants at about 60% accuracy. Conversely, rsFC signatures did not differentiate PTSD from ITRED-only individuals (45% accuracy). Common features differentiating TE-only participants from PTSD and ITRED-only participants mainly involved default mode network–related pathways. Some unique features, such as connectivity within the frontoparietal network, differentiated TE-only participants from one group (PTSD or ITRED-only) but to a lesser extent from the other group.</p></div><div><h3>Conclusions</h3><p>Neural network connectivity supports ITRED as a novel neurobiologically based approach to classifying posttrauma psychopathology.</p></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266717432300054X/pdfft?md5=7768ff356bdada4cbe512998b7b05bac&pid=1-s2.0-S266717432300054X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46127211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Search of the Behavioral and Neural Basis for Differentiating Fear and Anxiety","authors":"D. Caroline Blanchard ,&nbsp;Newton S. Canteras","doi":"10.1016/j.bpsgos.2023.05.008","DOIUrl":"10.1016/j.bpsgos.2023.05.008","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174323000836/pdfft?md5=36e4fe04e9f4d38f13b6e05668fd78de&pid=1-s2.0-S2667174323000836-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47378303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticosteroid Treatment During Sepsis Alters Hippocampal Function in Male and Female Survivors","authors":"Alice Hill ,&nbsp;Huzefa Khalil ,&nbsp;Klaudia Laborc ,&nbsp;Savannah Kounelis-Wuillaume ,&nbsp;Swapnil Gavade ,&nbsp;Colin Johnston ,&nbsp;Benjamin H. Singer ,&nbsp;Joanna L. Spencer-Segal","doi":"10.1016/j.bpsgos.2023.08.001","DOIUrl":"10.1016/j.bpsgos.2023.08.001","url":null,"abstract":"<div><h3>Background</h3><p>Millions of sepsis survivors annually face neuropsychiatric sequelae of their illness. Corticosteroids are frequently administered for sepsis, and their use improves neuropsychiatric outcomes, but the mechanisms are unknown. In light of prior work that has shown persistent inflammation in sepsis survivors, we hypothesized that short-term corticosteroid treatment during illness would reverse the long-term impact of sepsis on inflammatory gene expression in the hippocampus and rescue associated changes to affective behaviors.</p></div><div><h3>Methods</h3><p>Male and female mice underwent cecal ligation and puncture or a sham surgery to induce acute infection and were treated for 5 days with corticosterone or vehicle. Starting 2 weeks after the surgery, we performed functional phenotyping in the survivor mice followed by hippocampal RNA sequencing to identify underlying mechanisms.</p></div><div><h3>Results</h3><p>Long-term cecal ligation and puncture survivors exhibited anxiety-like behavior, increased central hypothalamic-pituitary-adrenal axis activity, and persistent systemic and neuroinflammation. Corticosterone treatment during illness did not reverse anxiety-like behavior or inflammation in survivors. Instead, corticosterone treatment impaired object memory and increased active coping behavior in females. History of corticosterone treatment influenced the expression of &gt;10% of detectable transcripts in the dorsal and ventral hippocampus, including a coordinated downregulation of activity-dependent genes.</p></div><div><h3>Conclusions</h3><p>Corticosterone treatment during sepsis impaired memory formation in survivors and caused a lasting decrease in hippocampal neural activity, which could underlie its effect on memory. Future studies should focus on how this lasting effect of corticosteroid treatment on hippocampal activity and memory translates into improved neuropsychiatric outcomes in human sepsis survivors.</p></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174323000903/pdfft?md5=f4e924f2a59efe9b48dae85297ac2610&pid=1-s2.0-S2667174323000903-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44553290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Dependent Attentional Impairments in a Subchronic Ketamine Mouse Model for Schizophrenia","authors":"Daisy L. Spark ,&nbsp;Sherie Ma ,&nbsp;Cameron J. Nowell ,&nbsp;Christopher J. Langmead ,&nbsp;Gregory D. Stewart ,&nbsp;Jess Nithianantharajah","doi":"10.1016/j.bpsgos.2023.05.003","DOIUrl":"10.1016/j.bpsgos.2023.05.003","url":null,"abstract":"<div><h3>Background</h3><p>The development of more effective treatments for schizophrenia targeting cognitive and negative symptoms has been limited, partly due to a disconnect between rodent models and human illness. Ketamine administration is widely used to model symptoms of schizophrenia in both humans and rodents. In mice, subchronic ketamine treatment reproduces key dopamine and glutamate dysfunction; however, it is unclear how this translates into behavioral changes reflecting positive, negative, and cognitive symptoms.</p></div><div><h3>Methods</h3><p>In male and female mice treated with either subchronic ketamine or saline, we assessed spontaneous and amphetamine-induced locomotor activity to measure behaviors relevant to positive symptoms, and used a touchscreen-based progressive ratio task of motivation and the rodent continuous performance test of attention to capture specific negative and cognitive symptoms, respectively. To explore neuronal changes underlying the behavioral effects of subchronic ketamine treatment, we quantified expression of the immediate early gene product, c-Fos, in key corticostriatal regions using immunofluorescence.</p></div><div><h3>Results</h3><p>We showed that spontaneous locomotor activity was unchanged in male and female subchronic ketamine–treated animals, and amphetamine-induced locomotor response was reduced. Subchronic ketamine treatment did not alter motivation in either male or female mice. In contrast, we identified a sex-specific effect of subchronic ketamine on attentional processing wherein female mice performed worse than control mice due to increased nonselective responding. Finally, we showed that subchronic ketamine treatment increased c-Fos expression in prefrontal cortical and striatal regions, consistent with a mechanism of widespread disinhibition of neuronal activity.</p></div><div><h3>Conclusions</h3><p>Our results highlight that the subchronic ketamine mouse model reproduces a subset of behavioral symptoms that are relevant for schizophrenia.</p></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174323000502/pdfft?md5=9dbece5415d92f8cad0fd972948d727e&pid=1-s2.0-S2667174323000502-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45462653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S2667-1743(23)00167-2","DOIUrl":"https://doi.org/10.1016/S2667-1743(23)00167-2","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174323001672/pdfft?md5=f450ce1a355cdb31d5ee4f9a8558f7f1&pid=1-s2.0-S2667174323001672-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139473475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could Cognitive Inflexibility Serve as a Potential Biomarker for Schizophrenia–Obsessive-Compulsive Disorder Spectrum?","authors":"Min-yi Chu ,&nbsp;Ling-ling Wang ,&nbsp;Simon S.Y. Lui ,&nbsp;Raymond C.K. Chan","doi":"10.1016/j.bpsgos.2023.11.001","DOIUrl":"https://doi.org/10.1016/j.bpsgos.2023.11.001","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174323001441/pdfft?md5=e3f3b084c974c3388799cb66819544c1&pid=1-s2.0-S2667174323001441-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139473537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disentangling Socioeconomic Status and Race in Infant Brain, Birth Weight, and Gestational Age at Birth: A Neural Network Analysis","authors":"Kathryn Sarullo ,&nbsp;Deanna M. Barch ,&nbsp;Christopher D. Smyser ,&nbsp;Cynthia Rogers ,&nbsp;Barbara B. Warner ,&nbsp;J. Philip Miller ,&nbsp;Sarah K. England ,&nbsp;Joan Luby ,&nbsp;S. Joshua Swamidass","doi":"10.1016/j.bpsgos.2023.05.001","DOIUrl":"10.1016/j.bpsgos.2023.05.001","url":null,"abstract":"<div><h3>Background</h3><p>Race is commonly used as a proxy for multiple features including socioeconomic status. It is critical to dissociate these factors, to identify mechanisms that affect infant outcomes, such as birth weight, gestational age, and brain development, and to direct appropriate interventions and shape public policy.</p></div><div><h3>Methods</h3><p>Demographic, socioeconomic, and clinical variables were used to model infant outcomes. There were 351 participants included in the analysis for birth weight and gestational age. For the analysis using brain volumes, 280 participants were included after removing participants with missing magnetic resonance imaging scans and those matching our exclusion criteria. We modeled these three different infant outcomes, including infant brain, birth weight, and gestational age, with both linear and nonlinear models.</p></div><div><h3>Results</h3><p>Nonlinear models were better predictors of infant birth weight than linear models (<em>R</em>² = 0.172 vs. <em>R</em>² = 0.145, <em>p</em> = .005). In contrast to linear models, nonlinear models ranked income, neighborhood disadvantage, and experiences of discrimination higher in importance than race while modeling birth weight. Race was not an important predictor for either gestational age or structural brain volumes.</p></div><div><h3>Conclusions</h3><p>Consistent with the extant social science literature, the findings related to birth weight suggest that race is a linear proxy for nonlinear factors related to structural racism. Methods that can disentangle factors often correlated with race are important for policy in that they may better identify and rank the modifiable factors that influence outcomes.</p></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174323000484/pdfft?md5=d0011fce10350d804ab4797ad313ce1f&pid=1-s2.0-S2667174323000484-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47976642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}