Biological psychiatry global open science最新文献

{"title":"Electrophysiological Biomarkers Reflect Target Engagement and Response Using Deep Brain Stimulation for Obsessive-Compulsive Disorder","authors":"Tine Van Bogaert ,&nbsp;Martijn Figee ,&nbsp;Brian H. Kopell ,&nbsp;Andrew Smith ,&nbsp;Jungho Cha ,&nbsp;Ha Neul Song ,&nbsp;Davide Momi ,&nbsp;Zarghona Imtiaz ,&nbsp;Sanjana Murthy ,&nbsp;Sonia Olson ,&nbsp;Elisa Xu ,&nbsp;Helen Mayberg ,&nbsp;Myles Mc Laughlin ,&nbsp;Ki Sueng Choi ,&nbsp;Allison C. Waters","doi":"10.1016/j.bpsgos.2025.100609","DOIUrl":"10.1016/j.bpsgos.2025.100609","url":null,"abstract":"<div><h3>Background</h3><div>Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) is an effective treatment for severe, treatment-resistant obsessive-compulsive disorder (OCD). However, optimizing lead placement and stimulation parameters remains a challenge. DBS evoked potentials (EPs) recorded with electroencephalography (EEG) during surgical lead placement could serve as intraoperative biomarkers for target engagement and clinical efficacy.</div></div><div><h3>Methods</h3><div>We obtained intraoperative EEG recordings on the forehead from 10 patients (2 nonresponders) undergoing ALIC DBS surgery for OCD. Monopolar stimulation at 2 Hz was delivered through all electrode contacts, and EEG EPs were analyzed in relation to stimulation contact, white matter connectivity to the prefrontal cortical regions of interest (assessed via probabilistic tractography), and reduction in symptom severity (assessed with the Yale-Brown Obsessive Compulsive Scale).</div></div><div><h3>Results</h3><div>We observed consistent DBS EPs with 3 oscillatory peaks (∼35, ∼75, and ∼120 ms) across all patients. EP amplitude varied across contacts, with the largest responses occurring when the location of stimulation overlapped with the preoperatively defined tractographic target. Higher EP amplitudes recorded on the forehead correlated with greater white matter connectivity to the ventromedial prefrontal cortex/orbitofrontal cortex and ventrolateral prefrontal cortex. Treatment nonresponders exhibited less consistent EP waveforms across lead contacts.</div></div><div><h3>Conclusions</h3><div>These findings suggest that intraoperative EPs provide valuable insights into ALIC DBS target engagement. EP characteristics may serve as biomarkers to refine DBS targeting and predict clinical response, offering a potential tool for optimizing DBS therapy for OCD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100609"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Coupling and Longitudinal Outcome Prediction in First-Episode Psychosis","authors":"Isaac Z. Pope ,&nbsp;Sidhant Chopra ,&nbsp;Alexander Holmes ,&nbsp;Shona M. Francey ,&nbsp;Brian O’Donoghue ,&nbsp;Vanessa L. Cropley ,&nbsp;Barnaby Nelson ,&nbsp;Hok Pan Yuen ,&nbsp;Kelly Allott ,&nbsp;Mario Alvarez-Jimenez ,&nbsp;Susy Harrigan ,&nbsp;Christos Pantelis ,&nbsp;Andrew Thompson ,&nbsp;Stephen J. Wood ,&nbsp;Patrick D. McGorry ,&nbsp;Alex Fornito","doi":"10.1016/j.bpsgos.2025.100589","DOIUrl":"10.1016/j.bpsgos.2025.100589","url":null,"abstract":"<div><h3>Background</h3><div>Clinical outcomes following the first episode of psychosis (FEP) are highly heterogeneous across patients. The identification of prognostic biomarkers would greatly facilitate personalized treatments. Patients with psychosis often display brainwide disruptions of interregional functional coupling (FC), with some being linked to symptom severity and remission. Thus, FC may have prognostic potential for people experiencing psychosis.</div></div><div><h3>Methods</h3><div>Fifty-five antipsychotic-naïve patients with FEP (51% female, ages 15–25 years) were randomized to receive either antipsychotic or placebo tablets for 6 months alongside psychosocial interventions. Functional magnetic resonance imaging was conducted at baseline and after 3 months to evaluate whether baseline FC or 3-month change in FC could predict 6- and 12-month changes in symptoms and functioning, quantified using the Brief Psychiatric Rating Scale and the Social and Occupational Functioning Assessment Scale, respectively. We considered 3 different cross-validated prediction algorithms: 1) connectome-based predictive modeling, 2) kernel ridge regression, and 3) multilayer meta-matching. Each prediction model comprised 35 to 49 individuals.</div></div><div><h3>Results</h3><div>All models showed poor performance in predicting patients’ 6- and 12-month changes in symptoms and functioning (all <em>r</em><em>_mean</em> &lt; 0.3), and no model achieved significance via permutation testing (all <em>p</em> &gt; .05).</div></div><div><h3>Conclusions</h3><div>Our findings suggest that brainwide measures of FC may not be suitable for predicting extended clinical outcomes over a 6- to 12-month period in patients with FEP.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100589"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichotillomania and Risk of Alcohol- and Drug-Related Problems","authors":"Luis C. Farhat ,&nbsp;Kayoko Isomura ,&nbsp;Ralf Kuja-Halkola ,&nbsp;Isabell Brikell ,&nbsp;Zheng Chang ,&nbsp;Brian M. D’Onofrio ,&nbsp;Henrik Larsson ,&nbsp;Paul Lichtenstein ,&nbsp;Lorena Fernández de la Cruz ,&nbsp;Anna Sidorchuk ,&nbsp;David Mataix-Cols","doi":"10.1016/j.bpsgos.2025.100605","DOIUrl":"10.1016/j.bpsgos.2025.100605","url":null,"abstract":"<div><h3>Background</h3><div>Trichotillomania is an understudied psychiatric disorder characterized by repeated hair-pulling resulting in hair loss. Little is known about the risk of problematic substance use in this patient group. In this nationwide matched cohort study, we investigated the association between trichotillomania and substance-related problems.</div></div><div><h3>Methods</h3><div>We linked various nationwide administrative and clinical registers in Sweden. Among 12,015,664 individuals living in the country from January 1, 1997, to December 31, 2020, we identified 1136 individuals with an ICD-10 diagnosis of trichotillomania at age ≥10 years (86.4% female, median age at first diagnosis 23.8 years [interquartile range 13.3–34.9 years]) and matched them with 11,360 unaffected individuals. The outcome was broadly defined as substance-related problems (alcohol- and drug-related disorders, suspected criminal offenses, and deaths). Stratified Cox proportional hazards regression was used to determine hazard ratios (HRs) for the association between trichotillomania and any substance-related problems.</div></div><div><h3>Results</h3><div>Over a mean follow-up period of 6 years, substance-related problems were recorded for 137 (12.1%) individuals with trichotillomania and 399 (3.5%) matched individuals (crude incidence rates per 1000 person-years of 21.6 and 5.6, respectively). After controlling for sociodemographic covariates and parental substance-related problems, trichotillomania was associated with an increased relative risk of substance-related problems (HR, 3.12; 95% CI, 2.53–3.85). Adjusting also for comorbid psychiatric history did not meaningfully change the findings.</div></div><div><h3>Conclusions</h3><div>Individuals with trichotillomania had a 3-fold increased risk of substance-related problems compared with unaffected individuals. Future research should examine the mechanisms underlying this association and inform the clinical management of the dual diagnoses.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100605"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Series of Young People Receiving Adjunctive Immunotherapy for Neuroimmune-Mediated Major Mood or Psychotic Syndromes","authors":"Elizabeth M. Scott ,&nbsp;David A. Brown ,&nbsp;Cathrin Rohleder ,&nbsp;Mirim Shin ,&nbsp;Shin H. Park ,&nbsp;Ian B. Hickie","doi":"10.1016/j.bpsgos.2025.100564","DOIUrl":"10.1016/j.bpsgos.2025.100564","url":null,"abstract":"<div><h3>Background</h3><div>Neuroimmune processes are often implicated in young people with atypical neuropsychiatric disorders, yet treatment implications remain controversial. This case series details young people with primary psychiatric disorders who received adjunctive immunotherapy after thorough investigation and extensive conventional treatments.</div></div><div><h3>Methods</h3><div>We evaluated 45 individuals (93% female, ages 12–30 years) with atypical psychiatric presentations suggesting potential neuroimmune involvement. Participants underwent clinical phenotyping, laboratory investigation, cerebrospinal fluid (CSF) analysis, neuroimaging, and/or electroencephalography. We tracked outcomes after personalized immunotherapy through global clinical improvement (Clinical Global Impressions-Global Improvement) and changes in social-occupational functioning (Social and Occupational Functioning Assessment Scale [SOFAS]), education/employment status (not in education, employment, or training [NEET]), psychiatric hospitalization, and medication use. Treatment response was assessed post-intervention, at 6 to 12 months, and at a long-term follow-up (78.2 ± 31.3 months).</div></div><div><h3>Results</h3><div>Participants presented with severe depression (80%), psychotic features (56%), treatment resistance (82%), and/or neurological symptoms (96%). Illness duration before immunotherapy was often prolonged (mean = 4.8 ± 4.7 years, median = 3 years). Autoantibodies were detected in serum or CSF in 64% of participants, while 91% showed elevated inflammatory markers. Of 43 individuals receiving immunotherapy, 88% experienced clinical improvement posttreatment, with 79% maintaining long-term benefits. Functional outcomes improved significantly: SOFAS scores increased from 43.2 ± 11.8 to 69.2 ± 9.8, while NEET rates declined from 81% to 14%. Psychiatric hospitalization dropped from 93% to 7%, and psychotropic medication use decreased from 84% to 9%. Earlier treatment predicted better outcomes (<em>p</em> = .025). Adverse effects occurred in 79% of participants, with 21% experiencing moderate-to-severe complications.</div></div><div><h3>Conclusions</h3><div>These findings suggest the importance of early identification and specialist assessment of atypical psychiatric presentations in young people. New guidelines need to support appropriate screening, personalized management, and long-term treatment and monitoring protocols.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100564"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutamate, Contextual Insensitivity, and Disorganized Speech in First-Episode Schizophrenia: A 7T Magnetic Resonance Spectroscopy Study","authors":"Yingqi Laetitia Wang ,&nbsp;Victoria Sharpe ,&nbsp;Michael Mackinley ,&nbsp;Gina R. Kuperberg ,&nbsp;Kaustubh Supekar ,&nbsp;Jean Theberge ,&nbsp;Lena Palaniyappan","doi":"10.1016/j.bpsgos.2025.100593","DOIUrl":"10.1016/j.bpsgos.2025.100593","url":null,"abstract":"<div><h3>Background</h3><div>In people with schizophrenia, formal thought disorder is a core symptom that emerges early and persists into chronic stages despite treatments. It manifests as disorganized speech and is often associated with poor long-term outcomes. A key feature of this disorganization is an impairment in the buildup and use of context provided by preceding words when choosing upcoming words. Recent work has shown that spoken words are less predictable based on global linguistic context in schizophrenia, but the neural basis of this remains unknown. Glutamate dysfunction in the anterior cingulate cortex has long been implicated in schizophrenia, but its connection to behavioral impairments remains unclear.</div></div><div><h3>Methods</h3><div>In this study, we investigated the relationship between linguistic contextual sensitivity and glutamate level in the dorsal anterior cingulate cortex in 39 patients with first-episode psychosis (33 men) and 33 sociodemographically matched healthy control participants (22 men). Contextual sensitivity was measured using a large language model (GPT-3), and glutamate levels were measured using 7T magnetic resonance spectroscopy.</div></div><div><h3>Results</h3><div>We found a significant interaction between diagnosis and glutamate level in predicting contextual sensitivity: Patients with lower glutamate levels had poor contextual sensitivity, a relationship not seen in healthy control participants. Glutamate variation was specifically explained by contextual sensitivity after controlling for other clinical and language variables, underscoring the robustness and specificity of this association.</div></div><div><h3>Conclusions</h3><div>These results highlight a potential glutamatergic basis for disorganized speech in schizophrenia and suggest that contextual sensitivity in speech could reflect anterior cingulate glutamate variations in early psychosis.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100593"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Connectivity in the Social Perception Pathway at Birth Is Linked to Attention to Faces at Four Months","authors":"Katarzyna Chawarska ,&nbsp;Angelina Vernetti ,&nbsp;Huili Sun ,&nbsp;Michelle Hampson ,&nbsp;Chenhao Li ,&nbsp;Suzanne Macari ,&nbsp;Kelly Powell ,&nbsp;R. Todd Constable ,&nbsp;Joseph Chang ,&nbsp;Laura R. Ment ,&nbsp;Dustin Scheinost","doi":"10.1016/j.bpsgos.2025.100597","DOIUrl":"10.1016/j.bpsgos.2025.100597","url":null,"abstract":"<div><h3>Background</h3><div>The right-lateralized social perception pathway, including the superior temporal sulcus, supports processing of dynamic, multimodal facial cues, while the right-lateralized ventral pathway, including the fusiform gyrus, is involved in processing static facial features. However, little is known about the early development of these pathways or their links to later social outcomes. In this study, we examined intrinsic functional connectivity (iFC) in these pathways in neonates with and without familial history of autism. We also investigated whether neonatal iFC was associated with reduced attention to faces at 4 months, an early autism biomarker.</div></div><div><h3>Methods</h3><div>iFC was measured in 310 full-term, typically developing neonates from the dHCP (Developing Human Connectome Project) at 41 weeks postmenstrual age (PMA) (SD = 1.7) and in 73 full-term Yale neonates with and without a family history of autism at 44 weeks PMA (SD = 1.3). Attention to faces was assessed at 4.1 months (SD = 0.3) via eye tracking in 37 Yale participants.</div></div><div><h3>Results</h3><div>All 4 pathways showed significant iFC (<em>p</em> &lt; .001), with no sex differences (<em>p</em> &gt; .159). Connectivity in the social pathway increased with age (<em>p</em> &lt; .001). In Yale neonates, only iFC in the right social pathway was positively associated with attention to faces at 4 months (<em>r</em>₃₇ = 0.456, <em>p</em> = .006). Greater attention to faces predicted fewer social concerns at 18 months (<em>r</em>₃₃ = −0.358, <em>p</em> = .010).</div></div><div><h3>Conclusions</h3><div>The right-lateralized social perception pathway represents an area of interest for identifying early neural markers of social vulnerabilities associated with autism.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100597"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Mitochondrial DNA Integrity and Elevated Inflammatory Markers in Late-Life Depression: A Longitudinal Study","authors":"Ana Paula Mendes-Silva ,&nbsp;Perla El-Ahmad ,&nbsp;Ana Paula Costa ,&nbsp;Lloyd Cenon Balbuena ,&nbsp;Yuliya Stoycheva Nikolova ,&nbsp;Tarek Rajji ,&nbsp;James Lowery Kennedy ,&nbsp;Erica Leandro Vieira ,&nbsp;Vanessa Faria Gonçalves ,&nbsp;Breno Satler Diniz","doi":"10.1016/j.bpsgos.2025.100598","DOIUrl":"10.1016/j.bpsgos.2025.100598","url":null,"abstract":"<div><h3>Background</h3><div>Late-life depression (LLD) is a prevalent and severe mental disorder. The biological mechanisms underlying LLD are not fully understood, but increasing evidence suggests that mitochondria play a significant role. Impaired mitochondrial function leads to excessive production of reactive oxygen species and the release of circulating cell-free mitochondrial DNA (ccf-mtDNA). The ccf-mtDNA activates the toll-like receptor system, which triggers a systemic proinflammatory response. However, there is limited understanding of the impact of ccf-mtDNA integrity, such as deletions, on LLD pathological conditions.</div></div><div><h3>Methods</h3><div>We included 90 older individuals (50 LLDs, 40 nondepressed healthy control participants [HCs]), with a subset of individuals followed up at 30 months (13 LLDs, 13 HCs). Plasma was separated from blood, and DNA was extracted. Mitochondrial genes MT-ND2 and MT-ND4 were targeted to evaluate ccf-mtDNA levels and deletion using real-time quantitative polymerase chain reaction. Plasma interleukins (ILs) 1β, 5, and 6 were quantified via multiplex immunoassay.</div></div><div><h3>Results</h3><div>LLD was linked to increased ccf-mtDNA instability at baseline (deletion: <em>F</em>_88,1 = 7.105, <em>p</em> = .009; levels: <em>F</em>_88,1 = 6.885, <em>p</em> = .01), which was associated with more severe depressive symptoms and greater medical comorbidity burden. Longitudinal analysis revealed significant effects of diagnosis and time on ccf-mtDNA levels and the deletion rate. Additionally, higher deletion rates at baseline predicted IL-5 and IL-6 levels at 30 months (<em>p</em>_adjusted = .13, <em>p</em>_adjusted = .12, respectively).</div></div><div><h3>Conclusions</h3><div>Increased ccf-mtDNA instability may heighten vulnerability to emotional dysregulation and medical burden in individuals with LLD. Further research is needed to validate our findings and elucidate the mechanisms that connect mitochondrial instability and inflammation in LLD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100598"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Critical Evaluation of Background Gene Omission in Imaging Transcriptomics","authors":"Zhipeng Cao ,&nbsp;Li Bao ,&nbsp;Jinmei Qin ,&nbsp;Guilai Zhan","doi":"10.1016/j.bpsgos.2025.100568","DOIUrl":"10.1016/j.bpsgos.2025.100568","url":null,"abstract":"<div><div>Imaging transcriptomics integrates spatial gene expression data with imaging-derived phenotypes (IDPs) to elucidate molecular mechanisms that underlie brain structure and function. Overrepresentation analysis (ORA) is widely used to annotate IDP-related genes; however, many studies have overlooked appropriate background gene selection. Here, we critically evaluated the impact of omitting a proper background on ORA findings. A systematic review of 152 imaging transcriptomics studies (2015–2024) revealed that 84.9% did not report background genes, and only 5.26% used the Allen Human Brain Atlas (AHBA) genes as background. Simulations showed that ORA significance increased with background size. In realistic simulations, default backgrounds (e.g., all protein-coding genes) inflated pathway significance by up to 50-fold, with probabilities reaching 0.97, particularly for frequently reported pathways related to synaptic signaling and neurotransmission. In contrast, using AHBA genes as the background maintained the significance probabilities near 0.05. These findings highlight the need for appropriate background selection and transparent reporting and we provide practical guidance for ORA in imaging transcriptomics.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100568"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Visuo-Tactile Temporal Binding Window Plasticity in Obsessive-Compulsive Disorder","authors":"Francesca Rastelli ,&nbsp;Davide Fausto Borrelli ,&nbsp;Francesca Ferroni ,&nbsp;Anna Di Donna ,&nbsp;Laura Dell’Uva ,&nbsp;Maurizio Cavazza ,&nbsp;Matteo Tonna ,&nbsp;Martina Ardizzi","doi":"10.1016/j.bpsgos.2025.100565","DOIUrl":"10.1016/j.bpsgos.2025.100565","url":null,"abstract":"<div><h3>Background</h3><div>Multisensory integration (MSI) enables the brain to combine sensory inputs by defining spatial and temporal boundaries that determine whether stimuli originate from the same event. Among these, the temporal binding window (TBW) specifically refers to the temporal range within which stimuli are perceived as simultaneous and integrated. In adulthood, TBW can be narrowed through short-term perceptual training. Altered TBW plasticity has been linked to neuropsychiatric conditions, where atypical prior weighting distorts sensory integration. This study investigates obsessive-compulsive disorder (OCD), a condition marked by heightened uncertainty and excessive reliance on real-time sensory input, potentially leading to wider MSI temporal boundaries and greater sensitivity to contingent sensory experiences.</div></div><div><h3>Methods</h3><div>In the current study, the TBW plasticity of 31 patients with OCD and 34 healthy control participants was studied by asking them to perform a simultaneity judgment task before and after a perceptual training session designed to narrow their TBW.</div></div><div><h3>Results</h3><div>Results showed a larger TBW with an abnormal tactile leading dominance in patients with OCD before the training session. Furthermore, patients with OCD showed a higher training gain than control participants.</div></div><div><h3>Conclusions</h3><div>These findings suggest altered TBW plasticity in OCD, potentially linked to difficulties in using past experiences as a stable source of information and an exaggerated reliance on real-time sensory input. Understanding these MSI alterations may offer new insights into the sensory mechanisms that underlie OCD and inform future research on sensory-based interventions.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100565"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocognitive Biotypes of Risk and Resilience for Mood Disorders in Adolescents: Insights From Behavioral and Graph-Theoretic Network Markers","authors":"Ambra Coccaro ,&nbsp;Ziwei Cheng ,&nbsp;Luka Ruzic ,&nbsp;Amelia D. Moser ,&nbsp;Jenna Jones ,&nbsp;Elena C. Peterson ,&nbsp;Elisa F. Stern ,&nbsp;Naomi P. Friedman ,&nbsp;Roselinde H. Kaiser","doi":"10.1016/j.bpsgos.2025.100563","DOIUrl":"10.1016/j.bpsgos.2025.100563","url":null,"abstract":"<div><h3>Background</h3><div>Adolescence is a developmental period of increased prevalence of mood disorders, but identifying adolescents who are at risk for or resilient to mood pathology remains a clinical challenge. In the current study, we addressed this challenge by evaluating multidimensional profiles of neurocognitive functioning (biotypes) that may confer vulnerability or protect against psychopathology. Biotypes were derived from neurocognitive data and identified as being resilient or high risk based on their association with future symptoms.</div></div><div><h3>Methods</h3><div>Adolescents (<em>N</em> = 146; 13–21 years, 66% first-degree familial history of mood disorders) completed behavioral tests and magnetic resonance imaging at baseline. Biotypes were derived using cluster analysis on measures of reward sensitivity and executive functioning. Over 2 years, participants reported on subjective life stress and symptoms of anhedonia or mania/hypomania. Regression analyses were used to test biotype differences in symptom variability (lability in mood symptoms) and life stress as a moderator of biotype-related differences.</div></div><div><h3>Results</h3><div>Biotype 1 (high executive functions, balanced integration/segregation of functional brain networks) was resilient: adolescents in this biotype reported low symptom variability, even under heightened life stress. Adolescents in biotype 2 (poor executive functions, low frontoparietal modularity) reported higher variability in symptoms of mania/hypomania overall. Adolescents in biotype 3 (mixed reward sensitivity, high overall network modularity) reported high variability in symptoms of anhedonia and mania/hypomania, if also reporting heightened life stress. Adolescents in biotype 4 (blunted reward decision processing, hyperconnected networks) reported high variability in symptoms of anhedonia, if also reporting heightened life stress.</div></div><div><h3>Conclusions</h3><div>Neurocognitive biotypes may identify adolescents who are resilient to, or at risk for, mood pathology.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100563"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}