Biological psychiatry global open science最新文献

{"title":"Assortative Mating Across the Full Spectrum of Mental Disorders: A Nationwide Finnish Register Study","authors":"Kateryna Golovina ,&nbsp;Mai Gutvilig ,&nbsp;Ripsa Niemi ,&nbsp;Christian Hakulinen","doi":"10.1016/j.bpsgos.2025.100642","DOIUrl":"10.1016/j.bpsgos.2025.100642","url":null,"abstract":"<div><h3>Background</h3><div>Previous research has shown assortative mating across various psychiatric disorders; however, their definitions of partnership have often been limited, and the timing of relationship formation has been imprecise. In this study, we aimed to comprehensively examine assortative mating across the full spectrum of mental disorders using population-wide register data from Finland that include information on the formation of both marriages and cohabiting unions.</div></div><div><h3>Methods</h3><div>We used nationwide data on all cohabitations and marriages between 2000 and 2020 from the Finnish Population Register (<em>n</em> = 1,271,242 partnerships). Broad and specific categories of mental disorder diagnoses were retrieved from both primary and secondary health care registers in Finland. We calculated tetrachoric correlations between partners’ mental disorder diagnoses, considering only diagnoses received before the start of cohabitation or marriage.</div></div><div><h3>Results</h3><div>Assortative mating was observed across the full spectrum of mental disorders, with the strongest within-disorder correlations for schizophrenia, psychotic disorders, organic mental disorders, and intellectual disabilities (<em>r</em> &gt; 0.50). Moderate correlations were found for mood and anxiety disorders. Adjusting for birth decade and excluding comorbidities slightly attenuated the associations but did not change the overall patterns.</div></div><div><h3>Conclusions</h3><div>This study suggests that assortative mating is prevalent in mental disorders. Assortative mating may contribute to the transmission and clustering of mental disorders within families, highlighting the importance of considering partner selection in mental health research and policy making.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100642"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy, Effectiveness, and Safety of Transcranial Magnetic Stimulation for Bipolar Depression: A Systematic Review and Meta-Analysis","authors":"Fabiana Ventura ,&nbsp;Pedro Frias ,&nbsp;Daniel Rodrigues da Silva ,&nbsp;Alexander McGirr ,&nbsp;Gonçalo Cotovio ,&nbsp;Albino J. Oliveira-Maia","doi":"10.1016/j.bpsgos.2025.100618","DOIUrl":"10.1016/j.bpsgos.2025.100618","url":null,"abstract":"<div><h3>Background</h3><div>Repetitive transcranial magnetic stimulation (rTMS) is cleared by the Food and Drug Administration for major depression, and recently received breakthrough status for bipolar depression (BDep). However, evidence on its efficacy and safety and optimal protocols for BDep remains limited. We conducted a systematic review to synthesize available data on rTMS for BDep.</div></div><div><h3>Methods</h3><div>We systematically searched 4 literature databases for studies published between 1995 and 2025 treating participants with acute BDep (1097 articles). The primary outcome for the meta-analysis was change in mean depression severity scores from baseline. Determinants of treatment response were assessed using meta-regression and subgroup meta-analyses.</div></div><div><h3>Results</h3><div>Fifty-six articles were included, representing a total of 1709 patients with BDep. Active TMS had superior antidepressant efficacy relative to sham in randomized controlled trials (RCTs) (Cohen’s <em>d</em> = 0.40). Rates of treatment-emergent mania or hypomania were low and equivalent to those found for sham (odds ratio = 1.3; 95% CI, 0.7–2.4). A large effect size for antidepressant effectiveness was found when pooling active arms of RCTs with data from uncontrolled studies (Cohen’s <em>d</em> = 1.4), with rates of response (46.81%) and remission (28.25%) similar to those described for MDD and preserved in subanalyses for high-frequency protocols, including intermittent theta burst stimulation (iTBS) delivered to the left dorsolateral prefrontal cortex (DLPFC) and low-frequency protocols delivered to the right DLPFC. Higher baseline illness severity and more treatment sessions were predictors of greater antidepressant effect.</div></div><div><h3>Conclusions</h3><div>TMS is efficacious and safe in BDep, with response and remission rates on par with rates for unipolar depression. High- and low-frequency protocols on the left and right DLPFC, respectively, are robustly associated with positive outcomes, with left DLPFC iTBS showing noninferiority to more widely used high-frequency rTMS protocols.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100618"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence Meets Ultra-High-Field Neuroimaging to Examine Psychosis","authors":"Deepak K. Sarpal","doi":"10.1016/j.bpsgos.2025.100641","DOIUrl":"10.1016/j.bpsgos.2025.100641","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100641"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Criteria to Guide Antineuronal Antibody Testing for People With Early and Persistent Psychosis Attending Mental Health Services","authors":"Gemma McKeon ,&nbsp;Andrea Baker ,&nbsp;Stefan Blum ,&nbsp;David Gillis ,&nbsp;Kerri Prain ,&nbsp;Judith M. Greer ,&nbsp;George Bruxner ,&nbsp;Michael E. Benros ,&nbsp;Sean Hatherill ,&nbsp;Shuichi Suetani ,&nbsp;Dan Siskind ,&nbsp;Kate Murphy ,&nbsp;Hitesh Joshi ,&nbsp;Jackie Curtis ,&nbsp;Brian O’Donoghue ,&nbsp;Iain Macmillan ,&nbsp;Eva Malacova ,&nbsp;Anita Pelecanos ,&nbsp;Patrick Waters ,&nbsp;Belinda Lennox ,&nbsp;James G. Scott","doi":"10.1016/j.bpsgos.2025.100612","DOIUrl":"10.1016/j.bpsgos.2025.100612","url":null,"abstract":"<div><h3>Background</h3><div>Early detection of autoimmune psychosis (AP) mediated by antineuronal antibodies (Abs) is critical for achieving optimal clinical outcomes. However, evidence remains limited regarding who should be tested and how Ab-positive cases should be managed. In this large-scale study, we evaluated proposed clinical criteria for targeted Ab testing in psychiatric services and described the clinical course of seropositive patients.</div></div><div><h3>Methods</h3><div>Individuals with early psychosis (EP) or persistent psychosis (PP) were prospectively assessed with clinical criteria to determine high- or low-risk status for AP. Blood samples were collected for Ab testing using a fixed cell-based assay. Seropositive individuals were invited for detailed review, including clinical, functional, and cognitive assessments at baseline and a 12-month follow-up. Blood samples were collected from 754 individuals (EP: <em>n</em> = 352, PP: <em>n</em> = 402).</div></div><div><h3>Results</h3><div>Abs were present in 2.3% (17/754), including 3.4% (12/352) of patients with EP and 1.2% (5/402) of patients with PP. AP was confirmed in 2 cerebrospinal fluid (CSF)–positive high-risk individuals (total: 2/754, 0.3%; EP: 1/352, 0.3%; PP: 1/402, 0.2%). Both improved with immunotherapy. Although some low-risk patients were seropositive, none were diagnosed clinically with AP.</div></div><div><h3>Conclusions</h3><div>AP prevalence was low in this cohort. Targeted testing informed by clinical high-risk criteria successfully identified 2 immunotherapy-responsive AP cases. This approach appears feasible but requires further validation. People with psychosis and high-risk AP features should be considered for Ab testing in sera and CSF where indicated. Further research is required to embed targeted Ab testing into mental health services.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100612"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Effects of Hypocretin Receptor Signaling in Corticotropin-Releasing Factor Neurons on Alcohol Drinking, Anxiety, and Extended Amygdala Neuronal Excitability","authors":"Yihe Ma ,&nbsp;Haniyyah Sardar ,&nbsp;Max E. Benabou ,&nbsp;Angeline C. Yu ,&nbsp;Allison R. Morningstar ,&nbsp;R. Nicolas Fajardo ,&nbsp;Isaac F. Kandil ,&nbsp;Ethan T. Rogers ,&nbsp;Anne Vassalli ,&nbsp;Julie A. Kauer ,&nbsp;William J. Giardino","doi":"10.1016/j.bpsgos.2025.100617","DOIUrl":"10.1016/j.bpsgos.2025.100617","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol use disorder (AUD) is characterized by compulsive alcohol consumption and negative emotional states during withdrawal, often perpetuating a cycle of addiction through arousal dysfunction. The hypocretin/orexin (HCRT) neuropeptide system is a key regulator of arousal that is implicated in these processes, particularly in its interactions with corticotropin-releasing factor (CRF) neurons within the bed nucleus of the stria terminalis (BNST).</div></div><div><h3>Methods</h3><div>Using CRF-specific genetic deletion of <em>Hcrt</em><em>r</em><em>1</em> and/or <em>Hcrt</em><em>r</em><em>2</em> receptors in mice combined with behavioral and electrophysiological approaches, we investigated the role of HCRT receptor signaling in CRF neurons in modulating alcohol intake, anxiety behaviors, and BNST excitability, with a focus on sex-specific differences.</div></div><div><h3>Results</h3><div>We found that deletion of <em>Hcrt</em><em>r</em><em>1</em> significantly reduced alcohol intake, with sex-specific effects on BNST excitability and synaptic drive. CRF-specific <em>Hcrt</em><em>r</em><em>2</em> deletion, while not affecting alcohol consumption, decreased baseline anxiety-like behaviors in males relative to females. Moreover, the double deletion of both HCRT receptors from CRF neurons led to reduced alcohol drinking in males (while tending to increase alcohol drinking in females) and dampened anxiety behaviors and BNST excitability in both sexes during protracted withdrawal.</div></div><div><h3>Conclusions</h3><div>These findings suggest that HCRT signaling in CRF neurons plays a critical role in the persistence of excessive alcohol consumption and the development of negative affective states, with distinct contributions from HcrtR1 and HcrtR2. The observed sex-specific differences underscore the need for tailored therapeutic approaches targeting the HCRT system in the treatment of AUD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100617"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Power Spectral Slope as a Novel Brain Functional Marker for Major Depressive Disorder","authors":"Huimin Zhou ,&nbsp;Kaini Qiao ,&nbsp;Jingjing Zhou ,&nbsp;Xuequan Zhu ,&nbsp;Zhi Yang ,&nbsp;Gang Wang ,&nbsp;Yanyu Wang ,&nbsp;Zhenxiang Zang","doi":"10.1016/j.bpsgos.2025.100623","DOIUrl":"10.1016/j.bpsgos.2025.100623","url":null,"abstract":"<div><h3>Background</h3><div>Resting-state functional magnetic resonance imaging (rs-fMRI) is a powerful tool to reveal disrupted brain activity in major depressive disorder (MDD), but most studies have focused solely on low-frequency functional fluctuations, ignoring the fact that brain activity is composed of both low-frequency and high-frequency fluctuations. Therefore, we applied a novel approach, namely the power spectral slope (PSS), which captures the characteristics of both low- and high-frequency fluctuations to evaluate brain activity in MDD.</div></div><div><h3>Methods</h3><div>rs-fMRI data were collected from 109 patients with MDD (27.29 ± 7.11 years, 75 women) and 78 normal control participants (26.47 ± 6.19 years, 51 women). A subset of 52 patients with MDD also underwent rs-fMRI scanning after a 12-week antidepressant treatment (escitalopram/duloxetine). Both the baseline between-group comparison and follow-up within-group comparison were performed for PSS. A 2-sample <em>t</em> test was used for baseline comparison with a liberal Gaussian random-field correction. The follow-up comparison was tested with paired <em>t</em> test.</div></div><div><h3>Results</h3><div>Patients with MDD showed significantly more negative PSS compared with normal control participants in the ventral striatum and temporal pole. After treatment, PSS in the ventral striatum increased significantly toward normalization, whereas the temporal pole’s slope remained unchanged. No significant correlations were found between PSS and depression severity scores.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that MDD is characterized by more negative PSS in key affective regions. The normalization effect of ventral striatum spectral slope following antidepressant treatment suggests a region-specific response. Taken together, the findings suggest that PSS may serve as a novel brain functional marker for MDD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100623"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autism Heterogeneity Related to Preterm Birth: Multi-Ancestry Results From the Simons Foundation Powering Autism Research for Knowledge Sample","authors":"Charikleia Chatzigeorgiou ,&nbsp;Zeynep Asgel ,&nbsp;Marina Natividad Avila ,&nbsp;Behrang Mahjani ,&nbsp;Vahe Khachadourian ,&nbsp;Tade Souaiaia ,&nbsp;Niamh Mullins ,&nbsp;Magdalena Janecka","doi":"10.1016/j.bpsgos.2025.100614","DOIUrl":"10.1016/j.bpsgos.2025.100614","url":null,"abstract":"<div><h3>Background</h3><div>Autism spectrum disorder (ASD) shows significant clinical variability, likely due to a combination of genetic and environmental factors. Preterm birth is a known risk factor for ASD, occurring in approximately 13% of diagnosed individuals. While genetic factors contribute to preterm birth in the general population, the relationship between genetic variation, preterm birth, and ASD heterogeneity remains unclear.</div></div><div><h3>Methods</h3><div>We investigated the genetic factors associated with preterm birth in 31,947 autistic individuals using data from the SPARK (Simons Foundation Powering Autism Research for Knowledge) sample. We conducted 3 ancestry-specific genome-wide association studies for African/African American, admixed American, and non-Finnish European ancestries, followed by a meta-analysis of 3308 preterm cases and 28,639 controls using METAL. Functional mapping and gene-based analyses were performed using FUMA, and genetic correlations were estimated using LDSC and Popcorn. Polygenic risk scores (PRSs) were computed with BridgePRS, using PRS of preterm birth in the general population.</div></div><div><h3>Results</h3><div>Our study identified ancestry-specific genetic loci associated with preterm birth in ASD cases. Although the meta-analysis results were not statistically significant, the estimated single nucleotide polymorphism heritability was 14%, indicating a meaningful contribution of common genetic variants. Across ancestry groups, preterm birth status was not significantly associated with PRSs for any psychiatric or medical conditions analyzed. However, polygenic liability to preterm birth in the general population was linked to several congenital anomalies after multiple testing adjustments.</div></div><div><h3>Conclusions</h3><div>These findings highlight the importance of diverse ancestries and early-life exposures in understanding ASD heterogeneity. Future research should replicate these findings in larger samples and explore rare variants associated with preterm birth to better understand the relationship between gestational duration and clinical and genetic differences in ASD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100614"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress-Induced Dysregulation of the Guidance Cue Receptor DCC Alters Corticolimbic Circuit Architecture","authors":"Ashraf Mahmud ,&nbsp;Giovanni Hernandez ,&nbsp;Fatme Abboud ,&nbsp;Cecilia Flores","doi":"10.1016/j.bpsgos.2025.100629","DOIUrl":"10.1016/j.bpsgos.2025.100629","url":null,"abstract":"<div><h3>Background</h3><div>Elevated expression of the guidance cue receptor gene <em>DCC</em> in the adult prefrontal cortex (PFC) is a hallmark of major depressive disorder. DCC receptors regulate neuronal connectivity and plasticity in adulthood. In male mice, <em>Dcc</em> knockout in the PFC promotes resilience to behavioral dysregulation following chronic social defeat stress (CSDS), whereas <em>Dcc</em> upregulation increases susceptibility. However, the underlying mechanisms remain to be elucidated.</div></div><div><h3>Methods</h3><div>We combined CSDS, behavioral tests (i.e., social interaction, nestlet shredding, and dark-light tests), retrograde neuronal tracing, and quantitative neuroanatomical analysis in adult male mice (<em>N</em> = 90) to investigate whether DCC receptors contribute to stress susceptibility/resilience by remodeling dendritic spine architecture of selective PFC neuronal networks.</div></div><div><h3>Results</h3><div>CSDS reduced both mature and newly formed spines on the apical, but not basal, dendrites of PFC pyramidal neurons. This effect was prevented by downregulating DCC receptors in these neurons, a manipulation that also prevented depression-like behaviors, suggesting a mechanistic link. DCC-expressing neurons in the PFC predominantly projected to the nucleus accumbens, and social defeat stress induced dendritic spine loss specifically in projections from the infralimbic PFC. Notably, knockout of DCC receptors in infralimbic PFC neurons projecting to the nucleus accumbens shell protected against stress-induced social avoidance.</div></div><div><h3>Conclusions</h3><div>DCC receptors may influence susceptibility or resilience to social stress–induced depression-like behaviors by altering the apical dendritic architecture of PFC pyramidal neurons, particularly those projecting to the nucleus accumbens shell. This mechanism may be at play in the neurobiology of depression, pointing to DCC receptors as promising therapeutic targets.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100629"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Trichotillomania","authors":"Jon E. Grant","doi":"10.1016/j.bpsgos.2025.100625","DOIUrl":"10.1016/j.bpsgos.2025.100625","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100625"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engagement of the Paraventricular Nucleus of the Thalamus During Withdrawal-Related Learning: Implications for Alcohol Use Disorder","authors":"Laureta Gashi ,&nbsp;Sophia Khom","doi":"10.1016/j.bpsgos.2025.100621","DOIUrl":"10.1016/j.bpsgos.2025.100621","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100621"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}