Biological psychiatry global open science最新文献

{"title":"Small Nucleolar RNAs and the Brain: Growing Evidence Supporting Their Role in Psychiatric Disorders","authors":"Juliette Salles ,&nbsp;Rixing Lin ,&nbsp;Gustavo Turecki","doi":"10.1016/j.bpsgos.2024.100415","DOIUrl":"10.1016/j.bpsgos.2024.100415","url":null,"abstract":"<div><div>Noncoding RNAs comprise most of the transcriptome and represent an emerging area of research. Among them, small nucleolar RNAs (snoRNAs) have emerged as a promising target because they have been associated with the development and evolution of several diseases, including psychiatric disorders. snoRNAs are expressed in the brain, with some showing brain-specific expression that indicates specific roles in brain development, function, and dysfunction. However, the role of snoRNAs in conditions that affect the brain needs further investigation to be better understood. This scoping review summarizes existing literature on studies that have investigated snoRNAs in psychiatry and offers insight into potential pathophysiological mechanisms to be further investigated in future research.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100415"},"PeriodicalIF":4.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In This Issue – November","authors":"","doi":"10.1016/j.bpsgos.2024.100403","DOIUrl":"10.1016/j.bpsgos.2024.100403","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100403"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2667-1743(24)00123-X","DOIUrl":"10.1016/S2667-1743(24)00123-X","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100410"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S2667-1743(24)00121-6","DOIUrl":"10.1016/S2667-1743(24)00121-6","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100408"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2667-1743(24)00120-4","DOIUrl":"10.1016/S2667-1743(24)00120-4","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100407"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgments","authors":"","doi":"10.1016/j.bpsgos.2024.100404","DOIUrl":"10.1016/j.bpsgos.2024.100404","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100404"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticotropin-Releasing Factor Modulates Binge-Like Ethanol Drinking in a Sex-Dependent Manner: Impact of Amygdala Deletion and Inhibition of a Central Amygdala to Lateral Hypothalamus Circuit","authors":"Sophie C. Bendrath ,&nbsp;Hernán G. Méndez ,&nbsp;Anne M. Dankert ,&nbsp;Jose Manuel Lerma-Cabrera ,&nbsp;Francisca Carvajal ,&nbsp;Ana Paula S. Dornellas ,&nbsp;Sophia Lee ,&nbsp;Sofia Neira ,&nbsp;Harold Haun ,&nbsp;Eric Delpire ,&nbsp;Montserrat Navarro ,&nbsp;Thomas L. Kash ,&nbsp;Todd E. Thiele","doi":"10.1016/j.bpsgos.2024.100405","DOIUrl":"10.1016/j.bpsgos.2024.100405","url":null,"abstract":"<div><h3>Background</h3><div>Binge alcohol drinking is a dangerous behavior that can contribute to the development of more severe alcohol use disorder. Importantly, the rate and severity of alcohol use disorder has historically differed between men and women, suggesting that there may be sex differences in the central mechanisms that modulate alcohol (ethanol) consumption. Corticotropin-releasing factor (CRF) is a centrally expressed neuropeptide that has been implicated in the modulation of binge-like ethanol intake, and emerging data highlight sex differences in CRF systems.</div></div><div><h3>Methods</h3><div>In the current report, we characterized CRF+ neurocircuitry arising from the central nucleus of the amygdala (CeA) and innervating the lateral hypothalamus (LH) in the modulation of binge-like ethanol intake in male and female mice.</div></div><div><h3>Results</h3><div>Using chemogenetic tools, we found that silencing the CRF+ CeA to LH circuit significantly blunted binge-like ethanol intake in male but not female mice. Consistently, genetic deletion of CRF from neurons of the CeA blunted ethanol intake exclusively in male mice. Furthermore, pharmacological blockade of the CRF₁ receptor in the LH significantly reduced binge-like ethanol intake in male mice only, while CRF₂ receptor activation in the LH failed to alter ethanol intake in either sex. Finally, a history of binge-like ethanol drinking reduced <em>C</em><em>rf</em> messenger RNA levels in the CeA regardless of sex.</div></div><div><h3>Conclusions</h3><div>These observations provide novel evidence that CRF+ CeA to LH neurocircuitry is more sensitive for modulating binge-like ethanol intake in male mice, which may provide insight into the mechanisms that guide known sex differences in binge-like ethanol intake.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100405"},"PeriodicalIF":4.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Depth of Meditation: Electroencephalography Insights From Expert Vipassana Practitioners","authors":"Nicco Reggente ,&nbsp;Christian Kothe ,&nbsp;Tracy Brandmeyer ,&nbsp;Grant Hanada ,&nbsp;Ninette Simonian ,&nbsp;Sean Mullen ,&nbsp;Tim Mullen","doi":"10.1016/j.bpsgos.2024.100402","DOIUrl":"10.1016/j.bpsgos.2024.100402","url":null,"abstract":"<div><h3>Background</h3><div>Meditation practices have demonstrated numerous psychological and physiological benefits, but capturing the neural correlates of varying meditative depths remains challenging. In this study, we aimed to decode self-reported time-varying meditative depth in expert practitioners using electroencephalography (EEG).</div></div><div><h3>Methods</h3><div>Expert Vipassana meditators (<em>n</em> = 34) participated in 2 separate sessions. Participants reported their meditative depth on a personally defined 1 to 5 scale using both traditional probing and a novel spontaneous emergence method. EEG activity and effective connectivity in theta, alpha, and gamma bands were used to predict meditative depth using machine/deep learning, including a novel method that fused source activity and connectivity information.</div></div><div><h3>Results</h3><div>We achieved significant accuracy in decoding self-reported meditative depth across unseen sessions. The spontaneous emergence method yielded improved decoding performance compared with traditional probing and correlated more strongly with postsession outcome measures. Best performance was achieved by a novel machine learning method that fused spatial, spectral, and connectivity information. Conventional EEG channel-level methods and preselected default mode network regions fell short in capturing the complex neural dynamics associated with varying meditation depths.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the feasibility of decoding personally defined meditative depth using EEG. The findings highlight the complex, multivariate nature of neural activity during meditation and introduce spontaneous emergence as an ecologically valid and less obtrusive experiential sampling method. These results have implications for advancing neurofeedback techniques and enhancing our understanding of meditative practices.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100402"},"PeriodicalIF":4.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychobiological Stress Response Profiles in Current and Remitted Depression: A Person-Centered, Multisystem Approach","authors":"Manuel Kuhn ,&nbsp;David C. Steinberger ,&nbsp;Jason José Bendezú ,&nbsp;Maria Ironside ,&nbsp;Min S. Kang ,&nbsp;Kaylee E. Null ,&nbsp;Devon L. Brunner ,&nbsp;Diego A. Pizzagalli","doi":"10.1016/j.bpsgos.2024.100400","DOIUrl":"10.1016/j.bpsgos.2024.100400","url":null,"abstract":"<div><h3>Background</h3><div>A dysregulated stress response, including exaggerated affective reactivity and abnormal hypothalamic-pituitary-adrenal axis responsivity, has been implicated in the etiology, maintenance, and relapse of major depressive disorder (MDD). Among adolescents, discordant affective and physiological stress response profiles have been linked to negative affective outcomes and increased risk for psychopathology. Whether these findings extend to adults with varying degree of MDD risk is unclear, as are possible links to various risk factors.</div></div><div><h3>Methods</h3><div>We used a person-centered, multisystem approach in a sample of 119 unmedicated adults with current or remitted MDD and individuals without past MDD to evaluate psychobiological stress response profiles. Multitrajectory modeling was applied to positive affect, negative affect, and salivary cortisol (CORT) levels in response to the Maastricht Acute Stress Test.</div></div><div><h3>Results</h3><div>Analyses identified 4 within-person profiles, 1 typical, termed normative (<em>n</em> = 32, 26.9%) and 3 atypical: CORT hyperreactivity affective stability (<em>n</em> = 17, 14.3%), CORT hyporeactivity affective reactivity 1 (<em>n</em> = 45, 37.8%), and CORT hyporeactivity affective reactivity 2 (<em>n</em> = 25, 21.0%). While validating the assumption of a normative profile and increased risk for psychopathology in non-normative stress response profiles, coherent associations emerged between stress response profiles and clinical status, depression severity, anhedonia, perceived stress, childhood adversity, and reports of well-being, suggesting increased risk for psychopathology for individuals with a hyperreactive or discordant hyporeactive stress response profile.</div></div><div><h3>Conclusions</h3><div>This work advances our understanding of stress response mechanisms in MDD and underscores the potential of targeted interventions to enhance resilience and reduce psychopathology based on individual stress response profiles.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100400"},"PeriodicalIF":4.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group Social Dynamics in a Seminatural Setup Reflect the Adaptive Value of Aggression in Male Mice","authors":"Sergey Anpilov ,&nbsp;Yair Shemesh ,&nbsp;Asaf Benjamin ,&nbsp;Tommaso Biagini ,&nbsp;Daniil Umanski ,&nbsp;Yehonatan Zur ,&nbsp;Yehezkel Sztainberg ,&nbsp;Alon Richter-Levin ,&nbsp;Oren Forkosh ,&nbsp;Alon Chen","doi":"10.1016/j.bpsgos.2024.100399","DOIUrl":"10.1016/j.bpsgos.2024.100399","url":null,"abstract":"<div><h3>Background</h3><div>Maladaptive aggression in humans is associated with several psychiatric conditions and lacks effective treatment. Nevertheless, tightly regulated aggression is essential for survival throughout the animal kingdom. Studying how social dominance hierarchies regulate aggression and access to resources in an enriched environment (EE) can narrow the translational gap between aggression in animal models and normal and pathological human behavior.</div></div><div><h3>Methods</h3><div>The social box is a seminatural setup for automatic and prolonged monitoring of mouse group dynamics. We utilized the social box to decipher tradeoffs between aggression, social avoidance, resource allocation, and dominance in 2 mouse models of increased aggression: 1) a model of early exposure to an EE and 2) a model of oxytocin receptor deficiency (<em>Oxt</em><em>r</em>^{<em>−/−</em>}). While environmental enrichment increases aggression as an adaptive response to external stimuli, hyperaggression in <em>Oxt</em><em>r</em>^{<em>−/−</em>} mice is accompanied by marked abnormalities in social behavior.</div></div><div><h3>Results</h3><div>EE groups exhibited significant social avoidance, and an increased proportion of their encounters developed into aggressive interactions, resulting in lower levels of exploratory activity and overall aggression. The hierarchy in EE groups was more stable than in control groups, and dominance was correlated with access to resources. In <em>Oxt</em><em>r</em>^{<em>−/−</em>} groups, mice engaged in excessive social encounters and aggressive chasing, accompanied by increased overall activity. In <em>Oxt</em><em>r</em>^{<em>−/−</em>} groups, dominance hierarchies existed but were not correlated with access to resources.</div></div><div><h3>Conclusions</h3><div>Measuring aggression and social dominance hierarchies in a seminatural setup reveals the adaptive value of aggression in EE and <em>Oxt</em><em>r</em>^{<em>−/</em>−} mice. This approach can enhance translational research on pathological aggression.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100399"},"PeriodicalIF":4.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}