Biological psychiatry global open science最新文献

{"title":"Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation-Associated Biomarkers Using Multiplex Profiling","authors":"Lauren Breithaupt ,&nbsp;Laura M. Holsen ,&nbsp;Chunni Ji ,&nbsp;Jie Hu ,&nbsp;Felicia Petterway ,&nbsp;Megan Rosa-Caldwell ,&nbsp;Ida A.K. Nilsson ,&nbsp;Jennifer J. Thomas ,&nbsp;Kyle A. Williams ,&nbsp;Regine Boutin ,&nbsp;Meghan Slattery ,&nbsp;Cynthia M. Bulik ,&nbsp;Steven E. Arnold ,&nbsp;Elizabeth A. Lawson ,&nbsp;Madhusmita Misra ,&nbsp;Kamryn T. Eddy","doi":"10.1016/j.bpsgos.2024.100332","DOIUrl":"10.1016/j.bpsgos.2024.100332","url":null,"abstract":"<div><h3>Background</h3><p>Proteomics offers potential for detecting and monitoring anorexia nervosa (AN) and its variant, atypical AN (atyp-AN). However, research has been limited by small protein panels, a focus on adult AN, and lack of replication.</p></div><div><h3>Methods</h3><p>In this study, we performed Olink multiplex profiling of 92 inflammation-related proteins in females with AN/atyp-AN (<em>n</em> = 64), all of whom were ≤90% of expected body weight, and age-matched healthy control individuals (<em>n</em> = 44).</p></div><div><h3>Results</h3><p>Five proteins differed significantly between the primary AN/atyp-AN group and the healthy control group (lower levels: HGF, IL-18R1, TRANCE; higher levels: CCL23, LIF-R). The expression levels of 3 proteins (lower IL-18R1, TRANCE; higher LIF-R) were uniquely disrupted in participants with AN in our primary model. No unique expression levels emerged for atyp-AN. In the total sample, 12 proteins (ADA, CD5, CD6, CXCL1, FGF-21, HGF, IL-12B, IL18, IL-18R1, SIRT2, TNFSF14, TRANCE) were positively correlated with body mass index and 5 proteins (CCL11, FGF-19, IL8, LIF-R, OPG) were negatively correlated with body mass index in our primary models.</p></div><div><h3>Conclusions</h3><p>Our results replicate the results of a previous study that demonstrated a dysregulated inflammatory status in AN and extend those results to atyp-AN. Of the 17 proteins correlated with body mass index, 11 were replicated from a previous study that used similar methods, highlighting the promise of inflammatory protein expression levels as biomarkers of AN disease monitoring. Our findings underscore the complexity of AN and atyp-AN by highlighting the inability of the identified proteins to differentiate between these 2 subtypes, thereby emphasizing the heterogeneous nature of these disorders.</p></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100332"},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000454/pdfft?md5=7a886594028244d17c0b0de18cd0c355&pid=1-s2.0-S2667174324000454-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141034852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S2667-1743(24)00039-9","DOIUrl":"https://doi.org/10.1016/S2667-1743(24)00039-9","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 3","pages":"Article 100326"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000399/pdfft?md5=f94107959a3ce1529847d2adcd28ebcd&pid=1-s2.0-S2667174324000399-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Antidepressant Actions of Subanesthetic Nitrous Oxide: Importance of Adequate Blinding and Opioid Receptors","authors":"Mark A. Gillman","doi":"10.1016/j.bpsgos.2024.100331","DOIUrl":"10.1016/j.bpsgos.2024.100331","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 4","pages":"Article 100331"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000442/pdfft?md5=42ffd1101fe8c6c24ef59801361ac472&pid=1-s2.0-S2667174324000442-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141030682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2667-1743(24)00038-7","DOIUrl":"https://doi.org/10.1016/S2667-1743(24)00038-7","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 3","pages":"Article 100325"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000387/pdfft?md5=fc73aef7d8139cd5a35efa25e24247ef&pid=1-s2.0-S2667174324000387-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2667-1743(24)00041-7","DOIUrl":"https://doi.org/10.1016/S2667-1743(24)00041-7","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 3","pages":"Article 100328"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000417/pdfft?md5=fe53e8e12fa79afb37723b36e0f12171&pid=1-s2.0-S2667174324000417-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Polygenic Scores to Go Beyond Examinations of Pathology Among Gender-Diverse Individuals","authors":"Alexandra S. Potter","doi":"10.1016/j.bpsgos.2024.100311","DOIUrl":"https://doi.org/10.1016/j.bpsgos.2024.100311","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 3","pages":"Article 100311"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000247/pdfft?md5=f8ab19843ca349d461acc749e7a6b331&pid=1-s2.0-S2667174324000247-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Pollution Burden on Neural Function During Implicit Emotion Regulation and Longitudinal Changes in Depressive Symptoms in Adolescents","authors":"Jessica P. Uy ,&nbsp;Justin P. Yuan ,&nbsp;Natalie L. Colich ,&nbsp;Ian H. Gotlib","doi":"10.1016/j.bpsgos.2024.100322","DOIUrl":"https://doi.org/10.1016/j.bpsgos.2024.100322","url":null,"abstract":"<div><h3>Background</h3><p>Exposure to environmental pollutants early in life has been associated with increased prevalence and severity of depression in adolescents; however, the neurobiological mechanisms underlying this association are not well understood. In the current longitudinal study, we investigated whether pollution burden in early adolescence (9–13 years) was associated with altered brain activation and connectivity during implicit emotion regulation and changes in depressive symptoms across adolescence.</p></div><div><h3>Methods</h3><p>One hundred forty-five participants (<em>n</em> = 87 female; 9–13 years) provided residential addresses, from which we determined their relative pollution burden at the census tract level, and performed an implicit affective regulation task in the scanner. Participants also completed questionnaires assessing depressive symptoms at 3 time points, each approximately 2 years apart, from which we calculated within-person slopes of depressive symptoms. We conducted whole-brain activation and connectivity analyses to examine whether pollution burden was associated with alterations in brain function during implicit emotion regulation of positively and negatively valenced stimuli and how these effects were related to slopes of depressive symptoms across adolescence.</p></div><div><h3>Results</h3><p>Greater pollution burden was associated with greater bilateral medial prefrontal cortex activation and stronger bilateral medial prefrontal cortex connectivity with regions within the default mode network (e.g., temporoparietal junction, posterior cingulate cortex, precuneus) during implicit regulation of negative emotions, which was associated with greater increases in depressive symptoms across adolescence in those exposed to higher pollution burden.</p></div><div><h3>Conclusions</h3><p>Adolescents living in communities characterized by greater pollution burden showed altered default mode network functioning during implicit regulation of negative emotions that was associated with increases in depressive symptoms across adolescence.</p></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 4","pages":"Article 100322"},"PeriodicalIF":0.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000351/pdfft?md5=d2028791b0e8716bf1b3f879e6c30f56&pid=1-s2.0-S2667174324000351-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141289216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Longitudinal Brain White Matter Microstructure Changes and Associated Polygenic Risk of Common Psychiatric Disorders and Alzheimer’s Disease in the UK Biobank","authors":"Max Korbmacher ,&nbsp;Dennis van der Meer ,&nbsp;Dani Beck ,&nbsp;Daniel E. Askeland-Gjerde ,&nbsp;Eli Eikefjord ,&nbsp;Arvid Lundervold ,&nbsp;Ole A. Andreassen ,&nbsp;Lars T. Westlye ,&nbsp;Ivan I. Maximov","doi":"10.1016/j.bpsgos.2024.100323","DOIUrl":"https://doi.org/10.1016/j.bpsgos.2024.100323","url":null,"abstract":"<div><h3>Background</h3><p>During the course of adulthood and aging, white matter (WM) structure and organization are characterized by slow degradation processes such as demyelination and shrinkage. An acceleration of such aging processes has been linked to the development of a range of diseases. Thus, an accurate description of healthy brain maturation, particularly in terms of WM features, is fundamental to the understanding of aging.</p></div><div><h3>Methods</h3><p>We used longitudinal diffusion magnetic resonance imaging to provide an overview of WM changes at different spatial and temporal scales in the UK Biobank (UKB) (<em>n</em> = 2678; age_{scan 1} = 62.38 ± 7.23 years; age_{scan 2} = 64.81 ± 7.1 years). To examine the genetic overlap between WM structure and common clinical conditions, we tested the associations between WM structure and polygenic risk scores for the most common neurodegenerative disorder, Alzheimer’s disease, and common psychiatric disorders (unipolar and bipolar depression, anxiety, obsessive-compulsive disorder, autism, schizophrenia, attention-deficit/hyperactivity disorder) in longitudinal (<em>n</em> = 2329) and cross-sectional (<em>n</em> = 31,056) UKB validation data.</p></div><div><h3>Results</h3><p>Our findings indicate spatially distributed WM changes across the brain, as well as distributed associations of polygenic risk scores with WM. Importantly, brain longitudinal changes reflected genetic risk for disorder development better than the utilized cross-sectional measures, with regional differences giving more specific insights into gene-brain change associations than global averages.</p></div><div><h3>Conclusions</h3><p>We extend recent findings by providing a detailed overview of WM microstructure degeneration on different spatial levels, helping to understand fundamental brain aging processes. Further longitudinal research is warranted to examine aging-related gene-brain associations.</p></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 4","pages":"Article 100323"},"PeriodicalIF":0.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000363/pdfft?md5=9cbaf26cc3387fbc0c5b8f6e21874558&pid=1-s2.0-S2667174324000363-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141313111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Differential Gene Expression in Developing Human Cortex and Its Intersection With Autism Risk Pathways","authors":"Lee T. Kissel ,&nbsp;Sirisha Pochareddy ,&nbsp;Joon-Yong An ,&nbsp;Nenad Sestan ,&nbsp;Stephan J. Sanders ,&nbsp;Xuran Wang ,&nbsp;Donna M. Werling","doi":"10.1016/j.bpsgos.2024.100321","DOIUrl":"https://doi.org/10.1016/j.bpsgos.2024.100321","url":null,"abstract":"<div><h3>Background</h3><p>Sex-differential biology may contribute to the consistently male-biased prevalence of autism spectrum disorder (ASD). Gene expression differences between males and females in the brain can indicate possible molecular and cellular mechanisms involved, although transcriptomic sex differences during human prenatal cortical development have been incompletely characterized, primarily due to small sample sizes.</p></div><div><h3>Methods</h3><p>We performed a meta-analysis of sex-differential expression and co-expression network analysis in 2 independent bulk RNA sequencing datasets generated from cortex of 273 prenatal donors without known neuropsychiatric disorders. To assess the intersection between neurotypical sex differences and neuropsychiatric disorder biology, we tested for enrichment of ASD–associated risk genes and expression changes, neuropsychiatric disorder risk genes, and cell type markers within identified sex-differentially expressed genes (sex-DEGs) and sex-differential co-expression modules.</p></div><div><h3>Results</h3><p>We identified 101 significant sex-DEGs, including Y-chromosome genes, genes impacted by X-chromosome inactivation, and autosomal genes. Known ASD risk genes, implicated by either common or rare variants, did not preferentially overlap with sex-DEGs. We identified 1 male-specific co-expression module enriched for immune signaling that is unique to 1 input dataset.</p></div><div><h3>Conclusions</h3><p>Sex-differential gene expression is limited in prenatal human cortex tissue, although meta-analysis of large datasets allows for the identification of sex-DEGs, including autosomal genes that encode proteins involved in neural development. Lack of sex-DEG overlap with ASD risk genes in the prenatal cortex suggests that sex-differential modulation of ASD symptoms may occur in other brain regions, at other developmental stages, or in specific cell types, or may involve mechanisms that act downstream from mutation-carrying genes.</p></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 4","pages":"Article 100321"},"PeriodicalIF":0.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266717432400034X/pdfft?md5=a150065d7585c067bce8ca6cadc4a6a1&pid=1-s2.0-S266717432400034X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141289217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unpredictable Mixed-Valence Outcomes Induce a Chronic and Reversible Generalized Anxiety-like Phenotype in Male Mice","authors":"Dylan W. Crawford,&nbsp;Komal R. Patel,&nbsp;Ashley Swiecka,&nbsp;Julia Bond,&nbsp;Alisha Tiwari,&nbsp;Nicole M. Plaisted,&nbsp;Nikita Rednam,&nbsp;Kelsey M. McKeen,&nbsp;Himali M. Patel,&nbsp;Pranu Sharma,&nbsp;Emilia Roslewicz,&nbsp;Louis D. Matzel","doi":"10.1016/j.bpsgos.2024.100318","DOIUrl":"10.1016/j.bpsgos.2024.100318","url":null,"abstract":"<div><h3>Background</h3><p>Clinical anxiety is a generalized state characterized by feelings of apprehensive expectation and is distinct from momentary responses such as fear or stress. In contrast, most laboratory tests of anxiety focus on acute responses to momentary stressors.</p></div><div><h3>Methods</h3><p>Apprehensive expectation was induced by subjecting mice (for 18 days) to manipulations in which a running response (experiment 1) or a conditioned stimulus (experiment 2) were unpredictably paired with reward (food) or punishment (footshock). Before this treatment, the mice were tested in an open field and light/dark box to assess momentary responses that are asserted to reflect state anxiety. After treatment, the mice were assessed for state anxiety in an elevated plus maze, social interaction test, startle response test, intrusive object burying test, and stress-induced corticosterone elevations. In experiment 3, we treated mice similarly to experiment 1, but after mixed-valence training, some mice received either no additional training, additional mixed-valence training, or were shifted to consistent (predictable) reinforcement with food.</p></div><div><h3>Results</h3><p>We consistently observed an increase in anxiety-like behaviors after the experience with mixed-valence unpredictable reinforcement. This generalized anxiety persisted for at least 4 weeks after the mixed-valence training and could be reversed if the mixed-valence training was followed by predictable reinforcement with food.</p></div><div><h3>Conclusions</h3><p>Results indicate that experience with unpredictable reward/punishment can induce a chronic state analogous to generalized anxiety that can be mitigated by exposure to stable, predictable conditions. This learned apprehension protocol provides a conceptually valid model for the study of the etiology and treatment of anxiety in laboratory animals.</p></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 4","pages":"Article 100318"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000314/pdfft?md5=f9714dcd03808ac6b4f8c33e1ce2c6b9&pid=1-s2.0-S2667174324000314-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140788215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}