Investigative Approaches to Resilient Emotion Regulation Neurodevelopment in a South African Birth Cohort

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science Pub Date : 2025-01-31 DOI:10.1016/j.bpsgos.2025.100457

Tristan Yates , Siphumelele Sigwebela , Soraya Seedat , Michael Milham , Stefan du Plessis , Lior Abramson , Erica Niemiec , Carol Worthman , Mary Jane Rotheram-Borus , Giovanni Salum , Alexandre Franco , Arianna Zuanazzi , Fatima Ahmed , Kelly Gemmell , Joan Christodoulou , Nomandla Mhlaba , Noluncedo Mqhele , Nomfusi Ngalimane , Akhona Sambudla , Nim Tottenham , Mark Tomlinson

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Abstract

Understanding the neurobiology of resilient emotion regulation following adversities is critical for addressing mental health problems globally. However, the functional neurobiology of resilience has rarely been studied in low- and middle-income countries, which comprise 90% of the world’s population and experience more consistent adversities. Here, we describe how we are investigating the neurodevelopment of resilient emotion regulation in adolescents (anticipated N = 525) from a South African birth cohort recruited from a low-income, high-adversity township. Across 2 longitudinal time points (13–14 and 15–16 years), magnetic resonance imaging, behavior, and self-report measures from adolescents and their caregivers are collected. These data are complemented by existing developmental histories (from the prenatal period to 8 years). The culturally adapted measures, protocols, and analytic plans for investigating resilient emotion regulation are presented. By characterizing neurodevelopmental correlates of adolescent resilience from an understudied low- and middle-income country, this research will provide deeper insights into mental health globally.

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南非出生队列中弹性情绪调节神经发育的调查方法

了解逆境后弹性情绪调节的神经生物学对于解决全球心理健康问题至关重要。然而，在低收入和中等收入国家，很少有关于恢复力的功能神经生物学的研究，这些国家占世界人口的90%，经历更持续的逆境。在这里，我们描述了我们是如何调查青少年弹性情绪调节的神经发育（预期N = 525），来自南非一个低收入，高逆境乡镇的出生队列。在两个纵向时间点（13-14岁和15-16岁），收集青少年及其照顾者的磁共振成像、行为和自我报告测量。现有的发育历史（从产前到8岁）补充了这些数据。提出了研究弹性情绪调节的文化适应措施、协议和分析计划。通过描述未充分研究的低收入和中等收入国家青少年恢复力的神经发育相关因素，本研究将为全球心理健康提供更深入的见解。

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