Biological psychiatry global open science最新文献

{"title":"Moving Toward Neurobiological, Multidomain, and Contextually Grounded Models of Resilience","authors":"Manpreet K. Singh","doi":"10.1016/j.bpsgos.2025.100603","DOIUrl":"10.1016/j.bpsgos.2025.100603","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100603"},"PeriodicalIF":3.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Relevance of Immunopsychiatric Treatment: Lessons From a Transdiagnostic Case Series on Young People","authors":"Luca Sforzini , Carmine M. Pariante","doi":"10.1016/j.bpsgos.2025.100600","DOIUrl":"10.1016/j.bpsgos.2025.100600","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100600"},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Head Motion, Age, and Psychiatric Diagnoses in a Large-Scale Developmental Sample","authors":"Jonathan Power, Conor Liston","doi":"10.1016/j.bpsgos.2025.100569","DOIUrl":"10.1016/j.bpsgos.2025.100569","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100569"},"PeriodicalIF":3.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Determinants of Health Influence Brain and Cognitive Function in Youth","authors":"Lucina Q. Uddin","doi":"10.1016/j.bpsgos.2025.100590","DOIUrl":"10.1016/j.bpsgos.2025.100590","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100590"},"PeriodicalIF":3.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145049660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Multi-Omic Signatures in the Understanding of Inflammation and Psychosis: Can Methylation-Derived White Blood Cell Proportions Guide Early Intervention?","authors":"Scott Richard Clark , Victoria Kiriaki Arnet , Magdalene C. Jawahar , Catherine Toben , K. Oliver Schubert , Azmeraw T. Amare","doi":"10.1016/j.bpsgos.2025.100580","DOIUrl":"10.1016/j.bpsgos.2025.100580","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100580"},"PeriodicalIF":3.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S2667-1743(25)00137-5","DOIUrl":"10.1016/S2667-1743(25)00137-5","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100583"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2667-1743(25)00139-9","DOIUrl":"10.1016/S2667-1743(25)00139-9","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100585"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2667-1743(25)00136-3","DOIUrl":"10.1016/S2667-1743(25)00136-3","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100582"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in High-Frequency Connectivity Among Large-Scale Functional Networks Linked to Major Depressive Disorder and Treatment-Resistant Depression","authors":"Ty Lees ,&nbsp;Sarah E. Woronko ,&nbsp;Mohan Li ,&nbsp;Jason N. Scott Jr. ,&nbsp;Manuel Kuhn ,&nbsp;Shiba M. Esfand ,&nbsp;Mario Bogdanov ,&nbsp;Brian W. Boyle ,&nbsp;Samantha R. Linton ,&nbsp;Lauren R. Borchers ,&nbsp;Peter Zhukovsky ,&nbsp;Courtney Miller ,&nbsp;Paula Bolton ,&nbsp;Shuang Li ,&nbsp;Robert C. Meisner ,&nbsp;Diego A. Pizzagalli","doi":"10.1016/j.bpsgos.2025.100602","DOIUrl":"10.1016/j.bpsgos.2025.100602","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) and treatment-resistant depression (TRD) have each been characterized by altered neural connectivity largely associated with the triple model of the default mode (DMN), frontoparietal (FPN), and salience (SN) networks. However, the direction (i.e., hyper- vs. hypoconnectivity) and the specificity (i.e., depression broadly vs. TRD) of these alterations remains unclear. Thus, in the current study, we compared high-frequency between- and within-network resting-state functional connectivity (rsFC) in healthy control (HC) individuals, individuals with MDD, and individuals with TRD.</div></div><div><h3>Methods</h3><div>Ninety-six channel resting-state electroencephalogram data were collected from 34 participants with MDD (22 women, mean ± SD age: 29.92 ± 9.57 years), 24 participants with TRD (16 women, age: 44.35 ± 15.86 years), and 34 HC participants (25 women, age: 32.49 ± 14.07 years). Based on previous findings, exact low-resolution electromagnetic tomography was used to estimate theta and beta rsFC within and between the DMN, FPN, and SN.</div></div><div><h3>Results</h3><div>Participants with depression (i.e., pooled MDD and TRD participants) had enhanced within-DMN beta1 (12.5–18 Hz) connectivity compared with controls. Compared with MDD participants, participants with TRD showed increased within-DMN, DMN to FPN, and FPN to SN beta3 (21.5–30 Hz) connectivity. These effects persisted when controlling for current depressive symptoms.</div></div><div><h3>Conclusions</h3><div>Differences in high-frequency rsFC, particularly in the beta bands, among the DMN, FPN, and SN may partially account for neural mechanisms of treatment resistance. However, future work probing the heterogeneity (e.g., medication status, age of onset, lifetime episode count) and time course (e.g., length and frequency of episodes) of depression is needed to increase our understanding of these changes in neural connectivity.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100602"},"PeriodicalIF":3.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of a DDX3X Gene Supplementation Therapy Including Expanded Characterization and Novel Findings of Sleep Disturbances in Ddx3x Haploinsufficient Mice","authors":"Andrea Boitnott ,&nbsp;Anjala Jiji ,&nbsp;Erik J. Plautz ,&nbsp;Yuhui Hu ,&nbsp;Xin Chen ,&nbsp;Steven J. Gray","doi":"10.1016/j.bpsgos.2025.100599","DOIUrl":"10.1016/j.bpsgos.2025.100599","url":null,"abstract":"<div><h3>Background</h3><div>DDX3X syndrome is a neurodevelopmental disorder caused by mutations in the <em>DDX3X</em> gene. It is one of many rare diseases for which there is no adequate treatment, but it has characteristics that make it potentially amenable to gene supplementation therapy.</div></div><div><h3>Methods</h3><div>An AAV9 (adeno-associated virus serotype 9)-mediated gene supplementation therapy was designed and tested for efficacy and safety in a mouse model of DDX3X syndrome. A total of 182 female <em>Ddx3x</em>^{<em>+/−</em>} mutant and <em>Ddx3x</em>^{<em>flox/+</em>} control littermates were dosed at postnatal day 1 with AAV9/DDX3X or vehicle and assessed throughout development for phenotypic benefit. To expand the readouts, sleep—a behavior disrupted in patients—was assessed by wireless telemetry.</div></div><div><h3>Results</h3><div>There was no effect of treatment on early postnatal developmental milestones. At 3 months, a dose-dependent amelioration in anxiety-like behavior was observed in treated <em>Ddx3x</em>^{<em>+/−</em>} mice, and a dose-dependent worsening in anxiety-like behavior was observed in treated <em>Ddx3x</em>^{<em>flox/+</em>} control mice. These treatment effects were not sustained at 12 months and were absent in mice that had not been subjected to prior developmental milestone testing. Significant sleep disturbances were observed in the <em>Ddx3x</em>^{<em>+/−</em>} mice at 4 months, but treatment had no effect on sleep.</div></div><div><h3>Conclusions</h3><div>While the gene therapy design used in this study was not effective, the data suggest that behavior can be modified by altering <em>Ddx3x</em> expression, warranting further exploration of gene therapy as a potential treatment approach. Additionally, the sleep disturbances present in <em>Ddx3x</em>^{<em>+/−</em>} mutant mice phenocopy the reduced sleep quality seen in patients, further validating this model for research.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100599"},"PeriodicalIF":3.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}