Biological psychiatry global open science最新文献

{"title":"No Laughing Matter: Nitrous Oxide and Depression","authors":"Ella Williams , Philip J. Cowen","doi":"10.1016/j.bpsgos.2025.100551","DOIUrl":"10.1016/j.bpsgos.2025.100551","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100551"},"PeriodicalIF":4.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextualizing Telomere Biology Through Biopsychological Plasticity: Insights From the Differential Susceptibility Hypothesis","authors":"Erika Comasco","doi":"10.1016/j.bpsgos.2025.100548","DOIUrl":"10.1016/j.bpsgos.2025.100548","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100548"},"PeriodicalIF":4.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward an Experimental Model to Study Dissociation in the Laboratory: Current Challenges and a Path Forward","authors":"Johannes B. Heekerens , Christian Schmahl","doi":"10.1016/j.bpsgos.2025.100549","DOIUrl":"10.1016/j.bpsgos.2025.100549","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100549"},"PeriodicalIF":4.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remember Me? Adolescent Thalamic Inhibition Leads to Deficits in Cortical Maturation and Social Memory","authors":"Isabel Bravo , Christoph Kellendonk","doi":"10.1016/j.bpsgos.2025.100543","DOIUrl":"10.1016/j.bpsgos.2025.100543","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100543"},"PeriodicalIF":4.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing NMDA Receptor Function Impacting Learning and Electroencephalogram Oscillations.","authors":"Tyler D Dexter, Jared W Young","doi":"10.1016/j.bpsgos.2025.100542","DOIUrl":"10.1016/j.bpsgos.2025.100542","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"100542"},"PeriodicalIF":4.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Mental and Neurological Illnesses Based on Cerebellar Normative Features","authors":"Milin Kim ,&nbsp;Nitin Sharma ,&nbsp;Esten H. Leonardsen ,&nbsp;Saige Rutherford ,&nbsp;Geir Selbæk ,&nbsp;Karin Persson ,&nbsp;Nils Eiel Steen ,&nbsp;Olav B. Smeland ,&nbsp;Torill Ueland ,&nbsp;Geneviève Richard ,&nbsp;Aikaterina Manoli ,&nbsp;Sofie L. Valk ,&nbsp;Dag Alnæs ,&nbsp;Christian F. Beckman ,&nbsp;Andre F. Marquand ,&nbsp;Ole A. Andreassen ,&nbsp;Lars T. Westlye ,&nbsp;Thomas Wolfers ,&nbsp;Torgeir Moberget ,&nbsp;Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.bpsgos.2025.100541","DOIUrl":"10.1016/j.bpsgos.2025.100541","url":null,"abstract":"<div><h3>Background</h3><div>Mental and neurological conditions have been linked to structural brain variations. However, aside from dementia, the value of brain structural characteristics derived from brain scans for prediction is relatively low. One reason for this limitation is the clinical and biological heterogeneity inherent to such conditions. Recent studies have implicated aberrations in the cerebellum, a relatively understudied brain region, in these clinical conditions.</div></div><div><h3>Methods</h3><div>Here, we used machine learning to test the value of individual deviations from normative cerebellar development across the lifespan (based on trained data from &gt;27,000 participants) for prediction of autism spectrum disorder (ASD) (<em>n</em> = 317), bipolar disorder (<em>n</em> = 238), schizophrenia (SZ) (<em>n</em> = 195), mild cognitive impairment (<em>n</em> = 122), and Alzheimer's disease (<em>n</em> = 116); individuals without diagnoses were matched to the clinical cohorts. We applied several atlases and derived median, variance, and percentages of extreme deviations within each region of interest.</div></div><div><h3>Results</h3><div>The results show that lobular and voxelwise cerebellar data can be used to discriminate reference samples from individuals with ASD and SZ with moderate accuracy (the area under the receiver operating characteristic curves ranged from 0.56 to 0.65). Contributions to these predictive models originated from both anterior and posterior regions of the cerebellum.</div></div><div><h3>Conclusions</h3><div>Our study highlights the utility of cerebellar normative modeling in predicting ASD and SZ, aided by 4 cerebellar atlases that enhanced the interpretability of the findings.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100541"},"PeriodicalIF":4.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response Monitoring Theta-Band Activities Across Emotional Contexts in Schizophrenia and Bipolar Spectrum Disorders","authors":"Takakuni Suzuki ,&nbsp;Margo W. Menkes ,&nbsp;Melvin G. McInnis ,&nbsp;Jian Kang ,&nbsp;Tara A. Niendam ,&nbsp;Maureen A. Walton ,&nbsp;Patricia J. Deldin ,&nbsp;Ivy F. Tso ,&nbsp;Stephan F. Taylor","doi":"10.1016/j.bpsgos.2025.100540","DOIUrl":"10.1016/j.bpsgos.2025.100540","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia spectrum disorder (SZ) and bipolar spectrum disorder (BD) have traditionally been treated as different conditions but share many characteristics, including cognitive control deficits. Electroencephalogram (EEG) indicators of response monitoring, including error-related negativity (ERN) and theta-band activities (4–8 Hz), have been proposed as transdiagnostic indicators of cognitive control. Research has found that the ERN and theta power are blunted in SZ, but findings have been less consistent in BD. Individuals with SZ and BD also show difficulty in emotional contexts. However, no research has investigated response-monitoring theta activities in SZ and BD concurrently or in emotional contexts.</div></div><div><h3>Methods</h3><div>Data were collected from 32 participants with SZ, 33 participants with BD, and 33 healthy control (HC) participants. EEG was recorded while participants completed 3 modified flanker tasks using arrow, unpleasant, and pleasant stimuli. Effects of group and task on postresponse event-related potentials (ERN, correct-related negativity), theta total power, and theta intertrial phase coherence (ITPC) were investigated using mixed analysis of covariance, controlling for age and accuracy.</div></div><div><h3>Results</h3><div>The SZ group did not show the ERN modulation by task that was found in the HC and BD groups. The SZ group showed attenuated theta power across all tasks, and the BD group showed attenuated power only on error trials with unpleasant stimuli. Both SZ and BD groups showed emotional modulation for theta ITPC. Theta power was correlated across tasks, suggesting that it is task invariant, while ITPC was not, suggesting that it is task-specific.</div></div><div><h3>Conclusions</h3><div>SZ and BD show different effects of emotional stimuli on cognitive control. To elucidate similarities and differences, concurrent data collection from individuals with SZ and BD across contexts is needed.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100540"},"PeriodicalIF":4.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco Smoking and Gray Matter Volume in Individuals at Clinical High Risk for Psychosis: A Longitudinal Magnetic Resonance Imaging Study","authors":"Merel Koster ,&nbsp;Marieke van der Pluijm ,&nbsp;Maura Fraikin ,&nbsp;Guido van Wingen ,&nbsp;Elsmarieke van de Giessen ,&nbsp;Lieuwe de Haan ,&nbsp;Jentien Vermeulen ,&nbsp;Tim Ziermans","doi":"10.1016/j.bpsgos.2025.100539","DOIUrl":"10.1016/j.bpsgos.2025.100539","url":null,"abstract":"<div><h3>Background</h3><div>Smoking is pervasive in young adults before psychosis onset and has been linked to worse clinical outcomes. Research suggests that smoking may play a role in psychosis pathogenesis, as increased smoking and gray matter reductions are associated with psychosis risk. However, a direct relationship in people at clinical high risk for psychosis (CHR-P) has not been established.</div></div><div><h3>Methods</h3><div>3T structural magnetic resonance imaging scans from the NAPLS-3 (North American Prodrome Longitudinal Study 3) were used. At baseline, 432 CHR-P nonsmokers and 110 CHR-P smokers were included, totaling 1617 scans across 2-, 4-, 6-, and 8-month follow-ups. Baseline gray matter volume differences between smoking and nonsmoking CHR-P were assessed with voxel-based morphometry. Linear mixed-effects models were used to examine association between smoking and gray matter volume across age in the superior frontal gyrus, anterior cingulate cortex, and insula. CHR-P individuals were categorized by tobacco use (no, low, high) to explore dose-response associations.</div></div><div><h3>Results</h3><div>At baseline, no significant differences in gray matter volume were observed between smoking and nonsmoking CHR-P individuals, regardless of the tobacco use level. Longitudinal analyses showed no significant group or group × age associations with gray matter volume between the 2 groups.</div></div><div><h3>Conclusions</h3><div>We observed no cross-sectional or longitudinal associations over 8 months between smoking and gray matter volume in CHR-P individuals. This suggests that no tobacco-related associations with gray matter volume reductions are evident yet in this vulnerable group, both in terms of psychosis and addiction risk. However, low smoking frequency and intensity in the current sample warrant further research with CHR-P individuals who are heavier smokers.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100539"},"PeriodicalIF":4.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Threats That Arise From Within: Changes in Error Processing and the Prospective Prediction of Everyday Avoidance","authors":"Claudia R. Becker ,&nbsp;Richard Morris ,&nbsp;Annmarie MacNamara","doi":"10.1016/j.bpsgos.2025.100536","DOIUrl":"10.1016/j.bpsgos.2025.100536","url":null,"abstract":"<div><h3>Background</h3><div>Errors are internally generated and can be harmful. Therefore, errors are considered endogenous threats. Like other forms of threat, errors receive increased processing in clinical anxiety, and enhanced error processing is predictive of anxiety onset in children. As is seen with other types of threat, avoidance of errors could also play a role in symptom worsening.</div></div><div><h3>Methods</h3><div>Seventy-four participants (56 female, 18 male) with internalizing psychopathology completed self-report measures and a flanker task during electroencephalography (EEG) recording at baseline (time 1) and 1 year later (time 2). Time 1 EEG event-related potentials, the error positivity (Pe) and the error-related negativity (ERN), as well as changes in error processing over 1 year, were examined as predictors of everyday avoidance (i.e., avoidance of anxiety-provoking stimuli in the real world) at time 2.</div></div><div><h3>Results</h3><div>Participants with greater elaborated processing of errors (Pe) at time 1 showed greater increases in everyday avoidance at time 2. This association was only evident for participants with reductions in early error processing (ERN) over the same time period, potentially indicating avoidance of errors in the laboratory. In addition, smaller time 2 ERNs were correlated with increased time 2 everyday avoidance.</div></div><div><h3>Conclusions</h3><div>Heightened elaborative error processing (indicative of sensitivity to endogenous threat) is predictive of increased everyday avoidance over 1 year. However, how patients respond to heightened elaborative error processing at baseline—i.e., via blunting of early error processing over the following year—is critical in determining worsening of everyday avoidance.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100536"},"PeriodicalIF":4.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144469985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Overexpression of the Mouse Ortholog of CACNA1C on Behavior and Cortical Dynamics","authors":"Rachel Parent ,&nbsp;Ruei-Lung Lin ,&nbsp;Lara Ouillette ,&nbsp;Emily Glass ,&nbsp;Hannah Burns ,&nbsp;Michael D. Uhler ,&nbsp;Sami L. Case ,&nbsp;Olivier Thibault ,&nbsp;Geoffrey G. Murphy","doi":"10.1016/j.bpsgos.2025.100537","DOIUrl":"10.1016/j.bpsgos.2025.100537","url":null,"abstract":"<div><h3>Background</h3><div>Mental disorders are common in the United States. According to the National Institute of Mental Health more than 23% of the adult population in the United States live with some form of mental illness. Genome-wide association studies have implicated <em>CACNA1C</em>, which encodes the L-type voltage-gated calcium channel Ca_V1.2, and it has been suggested that the expression levels of <em>CACNA1C</em> may be associated with mental illness. To this end, we have generated a novel mouse line that conditionally overexpresses the mouse ortholog <em>Cacna1c</em>.</div></div><div><h3>Methods</h3><div>Transgenic mice (Ca_V1.2^Tg+ mice) were characterized for expression and distribution of Ca_V1.2. The Ca_V1.2^Tg+ mice were compared with control littermates using assays that examined cognitive and affective behaviors. Cortical network dynamics were assessed using in vivo multiphoton calcium imaging.</div></div><div><h3>Results</h3><div>Compared with their control littermates, Ca_V1.2^Tg+ mice exhibited a ∼1-fold increase in Ca_V1.2 expression. Behavioral characterization of the Ca_V1.2^Tg+ mice revealed a complex phenotype in which they exhibited deficits in the consolidation of fearful memories and an increase in anxiolytic-like behavior. The Ca_V1.2^Tg+ mice also appeared to have altered cortical dynamics in which the network was more dense but less synchronized.</div></div><div><h3>Conclusions</h3><div>We have successfully generated mice that overexpress the mouse ortholog of a gene that has been implicated in several psychiatric diseases. Our initial characterization suggests that these mice have alterations in behavior and neural function that have been linked to mental illness. It is anticipated that future studies will reveal additional neurobehavioral alterations whose mechanisms will be studied.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 5","pages":"Article 100537"},"PeriodicalIF":4.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}