Biological psychiatry global open science最新文献

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2667-1743(25)00228-9","DOIUrl":"10.1016/S2667-1743(25)00228-9","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100674"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2667-1743(25)00225-3","DOIUrl":"10.1016/S2667-1743(25)00225-3","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100671"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NO Time to Die: Nitric Oxide’s Ongoing Relevance in Mental Disorders","authors":"Florian Freudenberg","doi":"10.1016/j.bpsgos.2025.100611","DOIUrl":"10.1016/j.bpsgos.2025.100611","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100611"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145365068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bipolar Disorder VII: Family History and Its Relationship With Suicide Attempts, Severity, and the Prophylactic Effect of Lithium Treatment in a Long-Term Follow-Up Study of Bipolar Disorder","authors":"Per-Olof Nylander ,&nbsp;Erik Lexne ,&nbsp;Christer Lehman ,&nbsp;Lars Brudin ,&nbsp;Finn Bengtsson","doi":"10.1016/j.bpsgos.2025.100608","DOIUrl":"10.1016/j.bpsgos.2025.100608","url":null,"abstract":"<div><h3>Background</h3><div>Family history (FH) of affective disorders (ADs) is important for the course of bipolar disorder (BD).</div></div><div><h3>Methods</h3><div>In a long-term study (mean 25 years), 192 patients with BD diagnosed by DSM-IV criteria were recruited from lithium dispensaries. Differences between patients with and without an FH of ADs were studied.</div></div><div><h3>Results</h3><div>Patients with an FH of AD had poorer lithium response (<em>p</em> = .027), earlier age of onset (AOO) (<em>p</em> &lt; .001), were younger (<em>p</em> = .009), made suicide attempts (SAs) earlier after onset (<em>p</em> = .012), and had more episodes/year (<em>p</em> = .017) and depressive episodes/year (<em>p</em> = .010) before SA. SAs were more common (<em>p</em> = .028) in patients with an FH of AD. SAs were more common (<em>p</em> = .001) before lithium treatment, and SAs (<em>p</em> &lt; .001) were only present in patients with an FH of AD within the first 5 years after AOO. Patients with an FH of AD had more episodes (<em>p</em> = .009), episodes/year (<em>p</em> = .002), depressive episodes (<em>p</em> &lt; .001), and depressive episodes/year (<em>p</em> &lt; .001) during their lifetime. Before lithium, episodes (<em>p</em> = .009), depressive episodes (<em>p</em> = .006), and depressive episodes/year (<em>p</em> = .010) were more common in patients with an FH of AD. Manic episodes (<em>p</em> = .020) were more common in patients with no FH of AD. On lithium, episodes (<em>p</em> = .010), episodes/year (<em>p</em> = .001), depressive episodes (<em>p</em> &lt; .001), and depressive episodes/year (<em>p</em> &lt; .001) were more common in patients with an FH of AD. FH of suicide was present only among patients with an FH of AD (<em>p</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>BD patients with an FH of AD have a more severe form of BD with a special effect on SAs, AOO, episodes, and lithium response in BD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100608"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145324651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical GABAergic Neuron Dysregulation in Schizophrenia Is Age Dependent","authors":"Daniel Kiss ,&nbsp;Xiaolin Zhou ,&nbsp;Nicole Endresz ,&nbsp;Keon Arbabi ,&nbsp;Alex Gonzalez Segura ,&nbsp;Daniel Felsky ,&nbsp;Andreea O. Diaconescu ,&nbsp;Etienne Sibille ,&nbsp;Shreejoy J. Tripathy","doi":"10.1016/j.bpsgos.2025.100606","DOIUrl":"10.1016/j.bpsgos.2025.100606","url":null,"abstract":"<div><h3>Background</h3><div>Cortical GABAergic (gamma-aminobutyric acidergic) neuron dysregulation is implicated in schizophrenia (SCZ), but it remains unclear whether these changes are due to altered cell proportions or per-cell changes in messenger RNA (mRNA) expression.</div></div><div><h3>Methods</h3><div>We analyzed 14 bulk and cell type–specific RNA sequencing (RNA-seq) datasets from 1408 individuals (672 SCZ cases, 736 controls) across 3 neocortical regions. We deconvolved GABAergic cell-subtype proportions from bulk RNA-seq and benchmarked them against single-nucleus RNA-seq and stereological densities from matched donors. We assessed SCZ- and age-associated changes in cell proportions and per-cell gene expression.</div></div><div><h3>Results</h3><div>SCZ was associated with altered proportions of neocortical parvalbumin (PVALB) and somatostatin (SST) cells, depending on the subject’s age at death. Younger SCZ cases (age &lt; 70 years) showed reduced PVALB and SST cell proportions, while older cases showed unchanged or increased proportions compared with controls. Earlier-onset SCZ, associated with more severe clinical symptoms, was linked to greater reductions in these cell types. Additionally, there was robust evidence for reduced per-cell SST and vasoactive intestinal peptide mRNA among younger cases with SCZ.</div></div><div><h3>Conclusions</h3><div>These findings suggest that SCZ is associated with complex, age-dependent alterations in GABAergic neurons, particularly affecting PVALB and SST cells. Our study underscores the importance of age-stratified analyses in SCZ, suggesting that distinct pathological processes underlie GABAergic neuron dysregulation across different age and symptom-severity groups and warranting tailored therapeutic approaches.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100606"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145324652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Maternal Genome-Wide Polygenic Scores for Psychiatric and Neurodevelopmental Disorders and Adverse Perinatal Events: A Danish Population-Based Study","authors":"Fenfen Ge ,&nbsp;Yue Wang ,&nbsp;Xiaoqin Liu ,&nbsp;Trine Munk-Olsen ,&nbsp;Kathrine Bang Madsen ,&nbsp;Emil Michael Pedersen ,&nbsp;Clara Albiñana ,&nbsp;Esben Agerbo ,&nbsp;Cynthia M. Bulik ,&nbsp;Liselotte Vogdrup Petersen ,&nbsp;Unnur A. Valdimarsdottir ,&nbsp;Bjarni Jóhann Vilhjálmsson","doi":"10.1016/j.bpsgos.2025.100613","DOIUrl":"10.1016/j.bpsgos.2025.100613","url":null,"abstract":"<div><h3>Background</h3><div>Phenotypic links between psychiatric disorders and adverse perinatal events are increasingly being reported, but the mechanisms remain unclear. In this study, we aimed to assess how polygenic scores (PGSs) for 8 psychiatric conditions influence perinatal risk.</div></div><div><h3>Methods</h3><div>The main analysis included 13,085 mothers and their corresponding birth information. PGSs for psychiatric conditions were estimated using genome-wide association study data (excluding the iPSYCH cohort) via LDpred2 and used as exposures. Ten adverse perinatal events from Danish national registers served as outcomes. Associations were analyzed using logistic or multinomial regression, with false discovery rate correction applied.</div></div><div><h3>Results</h3><div>We found that PGSs for psychiatric conditions were associated with heavy smoking (attention-deficit/hyperactivity disorder [ADHD], anxiety, and depression), lower likelihood of being overweight/obese (schizophrenia, anorexia nervosa, and obsessive-compulsive disorder [OCD]), very young maternal age (&lt;20 years) at childbirth (ADHD, depression, and anxiety), and non-cohabitation (ADHD, schizophrenia, anxiety, and depression). Little evidence of an association between maternal PGSs for psychiatric conditions and birth weight, gestational age, and labor presentation was identified. We identified a novel dose-response relationship in which higher PGSs for ADHD, anxiety, and depression were associated with a greater cumulative burden of adverse perinatal events, whereas higher PGSs for anorexia nervosa and OCD were linked to a lower burden.</div></div><div><h3>Conclusions</h3><div>High genetic liability for psychiatric conditions may partially explain the observed phenotypic associations between maternal mental illness and adverse perinatal events, with higher genetic liability generally associated with either an increase or decrease in the cumulative burden of adverse perinatal events in a dose-response–like manner.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100613"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiology and Functional Magnetic Resonance Imaging of Cue Craving: Potential Biomarkers for Therapeutic Neuromodulation in Addiction","authors":"Jody Tanabe ,&nbsp;Jordan Hickman ,&nbsp;Andy Tekriwal ,&nbsp;Joseph Sakai ,&nbsp;Aviva Abosch ,&nbsp;Steven Ojemann ,&nbsp;Joseph P. Schacht ,&nbsp;John A. Thompson","doi":"10.1016/j.bpsgos.2025.100622","DOIUrl":"10.1016/j.bpsgos.2025.100622","url":null,"abstract":"<div><div>A major goal for substance use disorder (SUD) treatment is the reduction of drug craving, which contributes to continued drug use and relapse. Pathological craving is thought to reflect dysfunction in neural networks, sparking a growing interest in modulating the mesocorticolimbic reward and related networks to decrease craving and improve outcomes. Although initial studies of neuromodulation in SUDs have produced promising results, biomarkers for craving remain elusive. Advances in deep brain stimulation (DBS) now allow recording of local field potentials (LFPs) in the nucleus accumbens (NAc), the central hub of the reward circuit, thus paving the way for a novel LFP biomarker for craving. Insights into mechanistic models of craving that relate localized electrophysiology to distributed circuit activity are in the earliest stages. At the same time, performing invasive DBS surgery on individuals with SUD is a formidable challenge and underscores the need to refine our understanding of noninvasive functional magnetic resonance imaging (fMRI)–defined network biomarkers of craving. Here, we review the literature on LFPs and single-unit neural activity during craving and reward, highlighting recent findings of craving-related NAc LFPs in humans. Next, we review fMRI studies of cue craving in the context of potential neuromodulation targets based on a triple network model. Third, we briefly review relationships between electrophysiology and fMRI in general. Lastly, we suggest future research directions that integrate neuromodulation, electrophysiological recording, and neuroimaging to improve our understanding of craving in SUD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100622"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Episodic Memory With Multiomics Scores","authors":"Anni L.K. Malmberg ,&nbsp;Matti Pirinen ,&nbsp;Johannes Kettunen ,&nbsp;Katri Räikkönen ,&nbsp;Johan G. Eriksson ,&nbsp;Jari Lahti","doi":"10.1016/j.bpsgos.2025.100607","DOIUrl":"10.1016/j.bpsgos.2025.100607","url":null,"abstract":"<div><h3>Background</h3><div>Episodic memory (EM) refers to the ability to encode and recall events—a vital cognitive function for healthy cognitive aging and an endophenotype for dementia.</div></div><div><h3>Methods</h3><div>Using genome- and metabolome-wide least absolute shrinkage and selection operator (LASSO) analysis, we developed polygenic (LASSO-PRS) and metabolic risk scores (MRS) in ∼68.5-year-old individuals (<em>n</em> = 897). We also applied the Bayesian regression method PRS-CS to an external genome-wide meta-analysis (GWAMA, <em>N</em> = 29,785, age &gt; 18 years) to derive another PRS (GWAMA-PRS). We assessed incremental variances (<em>R</em>²) in EM explained by the PRSs and MRS separately and in combination beyond the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) score in 104 independent ∼68.5-year-old individuals. Finally, we validated the PRSs in 2 independent pediatric cohorts (<em>N</em> = 309, age = ∼11.9 years; <em>N</em> = 443, age = ∼8.6 years).</div></div><div><h3>Results</h3><div>In the independent sample of ∼68.5-year-old individuals, compared with CAIDE score alone, accounting additionally for either MRS, LASSO-PRS, or GWAMA-PRS increased <em>R</em>² by 1.6, 5.6, and 4.5 percentage points (pp), respectively, while accounting additionally for MRS + LASSO-PRS or MRS + GWAMA-PRS increased <em>R</em>² by 7.8 and 6.4 pp, respectively. Both LASSO-PRS (all false discovery rate [FDR]–adjusted <em>p</em> values = .01–.03) and GWAMA-PRS (all FDR-adjusted <em>p</em> values = .03) were significantly associated with EM in all models, while the CAIDE score and MRS were not (all FDR-adjusted <em>p</em> values &gt; .05). PRSs were not associated with EM in the pediatric cohorts (all FDR-adjusted <em>p</em> values &gt; .05).</div></div><div><h3>Conclusions</h3><div>Genomics added predictive value to EM beyond epidemiological risk factors in adults, but the same was not observed with metabolomics. Adult-derived PRSs did not predict EM in children.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100607"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145324650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Shifts and Scientific Influence in Treatment-Resistant Depression Research: A Data-Driven Perspective","authors":"Yunsheng Liu ,&nbsp;Zengwei Kou","doi":"10.1016/j.bpsgos.2025.100610","DOIUrl":"10.1016/j.bpsgos.2025.100610","url":null,"abstract":"<div><h3>Background</h3><div>Treatment-resistant depression (TRD) remains a major psychiatric challenge, with therapeutic paradigms evolving over the last 50 years. However, research on TRD is fragmented across molecular mechanisms, clinical interventions, and epidemiological trends, highlighting the need for a comprehensive synthesis to guide future studies and enhance clinical outcomes.</div></div><div><h3>Methods</h3><div>We conducted a large-scale bibliometric analysis of 16,198 TRD-related publications from PubMed, Web of Science, and Scopus (1974–2025). Using CiteSpace, VOSviewer, and Bibliometrix, we quantified publication trends, collaborative networks, and thematic shifts. Special attention was paid to influential researchers and institutions, as well as examining the shifting research focus from traditional invasive therapies, including deep brain stimulation, to emerging pharmacological advancements such as ketamine-based treatments.</div></div><div><h3>Results</h3><div>We identified leading countries, institutions, and key contributors on TRD research. Thematic clusters revealed sustained focus on neurobiological mechanisms (glutamate dysfunction, inflammation) and clinical efficacy. A pivotal shift from invasive techniques (dominant before 2000) to ketamine-based therapies was observed, with ketamine-related publications surging after 2010. High-impact journals such as <em>Biological Psychiatry</em> and <em>American Journal of Psychiatry</em> anchored 3 intellectual clusters: molecular neuropharmacology, pathophysiology, and clinical psychiatry. Despite progress, gaps persist in understanding ketamine’s systemic effects and noncanonical NMDA receptor roles.</div></div><div><h3>Conclusions</h3><div>This bibliometric study traces TRD research evolution from the 1970s onward, revealing key shifts from invasive interventions to novel pharmacotherapies such as ketamine, a transformative advance highlighting a mechanism-driven approach. By analyzing influential contributors, collaborations, and emerging trends, our work synthesizes decades of fragmented knowledge, providing clinicians and researchers with a cohesive road map for future TRD investigations.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100610"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145324657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Neurocircuitry of Cannabis Cue Reactivity in Cannabis Use Disorder: A Functional Neuroimaging Study","authors":"Valentina Lorenzetti ,&nbsp;Hannah Sehl ,&nbsp;Arush Honnedevasthana Arun ,&nbsp;Eugene McTavish ,&nbsp;Adam Clemente ,&nbsp;Hannah Thomson ,&nbsp;Marianna Quinones-Valera ,&nbsp;Alexandra Gaillard ,&nbsp;Emillie Beyer ,&nbsp;Diny Thomson ,&nbsp;Janna Cousijn ,&nbsp;Izelle Labuschagne ,&nbsp;Peter Rendell ,&nbsp;Gill Terrett ,&nbsp;Chao Suo ,&nbsp;Lisa-Marie Greenwood ,&nbsp;Victoria Manning ,&nbsp;Govinda Poudel","doi":"10.1016/j.bpsgos.2025.100638","DOIUrl":"10.1016/j.bpsgos.2025.100638","url":null,"abstract":"<div><h3>Background</h3><div>A common feature of cannabis use disorder (CUD) is an intense reactivity to cannabis cues, which are becoming increasingly visible due to the growth in its decriminalization, accessibility, and marketing of cannabis products. The brain’s automatic reactivity to cannabis cues can trigger craving and subsequent use. In this study, we aimed to test neural activity during cannabis cue reactivity in non–treatment-seeking individuals with moderate-to-severe CUD and past attempts to cut down/quit.</div></div><div><h3>Methods</h3><div>The study examined 65 individuals with moderate-to-severe CUD and 43 control participants, with a functional magnetic resonance imaging cannabis cue-reactivity task and assessment of mental health and substance use as well as cognitive testing. Group differences in neural responses to cannabis cue reactivity were examined, adjusting for age and sex; correlations with cannabis use characteristics and mental health variables were assessed, accounting for recent substance use.</div></div><div><h3>Results</h3><div>Compared with control participants, individuals with CUD showed greater brain activity during cannabis cue reactivity in the superior/middle occipital, medial/lateral orbitofrontal cortex, anterior/posterior cingulate, cerebellar, hippocampus, and middle temporal and lateral parietal cortices (<em>p</em> &lt; .05; cluster <em>k</em> &gt; 10, familywise error corrected). Greater occipital/cerebellar activity correlated with greater subjective arousal toward cannabis images and cannabis withdrawal scores, while anterior cingulate/inferior parietal activity negatively correlated with urinary level of 11-Nor-9-carboxy-Δ⁹-tetrahydrocannabinol:creatinine (<em>p</em>s &lt; .05).</div></div><div><h3>Conclusions</h3><div>Exposure to cannabis cues can elicit greater activity within salience evaluation/attention, motivation, and disinhibition pathways of addiction neurocircuitry in people with moderate-to-severe CUD, consistent with prominent neuroscientific theories of addiction and findings with other substances. Interventions that can suppress brain activity in salience and attention circuits during cannabis cue reactivity may help reduce craving and subsequent use.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100638"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}