Biological psychiatry global open science最新文献

{"title":"Negative Schizotypy: Now That We Know What It Is, Should We Do Something About It?","authors":"Philip D. Harvey","doi":"10.1016/j.bpsgos.2024.100354","DOIUrl":"10.1016/j.bpsgos.2024.100354","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100354"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000673/pdfft?md5=cb5e1b98eb5d0e69b1f2617a23648720&pid=1-s2.0-S2667174324000673-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2667-1743(24)00094-6","DOIUrl":"10.1016/S2667-1743(24)00094-6","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 5","pages":"Article 100381"},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000946/pdfft?md5=e4c107b2955882d1f85d260b960e176f&pid=1-s2.0-S2667174324000946-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Borderline Personality Disorder Symptoms and Stressful Life Events: An Evaluation of Gene-Environment Interplay","authors":"Vilde Sofie Arneberg ,&nbsp;Vilde Sundsvold ,&nbsp;Ludvig Daae Bjørndal ,&nbsp;Eivind Ystrom","doi":"10.1016/j.bpsgos.2024.100390","DOIUrl":"10.1016/j.bpsgos.2024.100390","url":null,"abstract":"<div><h3>Background</h3><div>Borderline personality disorder (BPD) is associated with high rates of stressful life events (SLEs). It is unclear whether people who experience SLEs have more BPD symptoms after accounting for the effects of familial risk factors. Our aims in the current study were to 1) create a predictive model of BPD using stressors across age and contexts and 2) examine whether SLEs resulted in higher levels of BPD symptoms beyond the effects of genetic and environmental risk factors.</div></div><div><h3>Methods</h3><div>The sample comprised 2801 twins from the Norwegian Institute of Public Health Twin Panel. Poisson regression was used to explore which SLEs predicted BPD symptoms. Elastic net penalized regression was conducted to develop a predictive model for SLEs and BPD symptoms. Co-twin control analyses were performed to differentiate between environmental and genetic factors.</div></div><div><h3>Results</h3><div>SLEs experienced during childhood and adulthood were associated with BPD symptoms. A weighted polyevent risk score explained 22% of the total variation in symptoms. Shared environmental and heritable factors explained 31% and 47% of individual differences in BPD symptomatology, respectively. Measured SLEs explained 42% of the shared environmental risk for BPD. The predictive risk of SLEs for BPD was reduced when shared environmental and genetic factors were accounted for. However, SLEs increased risk of BPD symptoms beyond the effects of shared genetic and environmental factors.</div></div><div><h3>Conclusions</h3><div>BPD symptomatology following SLEs cannot fully be explained by genetic and shared environmental factors. The SLE-BPD symptoms associations were primarily due to selection by family environments. It is important to identify familial factors that lead to both SLEs and BPD symptoms. SLEs remained associated with BPD symptoms beyond genetic and environmental confounding.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100390"},"PeriodicalIF":4.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of Anxiety- and Depressive-Like Behaviors in Rodent Models of Neuropathic Pain","authors":"Tomás de la Rosa ,&nbsp;Meritxell Llorca-Torralba ,&nbsp;Adrián Martínez-Cortés ,&nbsp;Cristina Romero-López-Alberca ,&nbsp;Esther Berrocoso","doi":"10.1016/j.bpsgos.2024.100388","DOIUrl":"10.1016/j.bpsgos.2024.100388","url":null,"abstract":"<div><h3>Background</h3><div>Epidemiological studies have frequently shown the concurrence of chronic pain with symptoms of anxiety and depression, particularly in women. Animal models are useful to understand the complex mechanisms underlying comorbidities, but the wide range of methods employed and the wealth of evidence sometimes impedes effective translation and reproducibility. In this systematic review and meta-analysis, we aimed to synthesize the evidence regarding the influence of variables such as sex and species on anxiety- and depressive-like behaviors in rodent models of neuropathic pain.</div></div><div><h3>Methods</h3><div>Following PROSPERO registration, we searched EMBASE, Scopus, and the Web of Science from their inception to November 24, 2023, identifying 126 studies that met the inclusion criteria. The Hedges’ <em>g</em> value for each experiment and study was calculated, and further subgroup and meta-regression analyses were performed.</div></div><div><h3>Results</h3><div>Neuropathic pain significantly reduced the time that rats and mice spent in the open arms of the elevated plus and zero mazes (<em>g</em> = −1.14), time spent in the center of the open field (<em>g</em> = −1.12), sucrose consumption in the sucrose preference test (<em>g</em> = −1.43), and grooming time in the splash test (<em>g</em> = −1.37) while increasing latency to feed in the novelty-suppressed feeding test (<em>g</em> = 1.59) and immobility in the forced swimming (<em>g</em> = 1.85) and tail suspension (<em>g</em> = 1.91) tests. Sex differences were observed, with weaker effects in female than in male rodents for several behavioral paradigms, and funnel plots identified positive publication bias in the literature.</div></div><div><h3>Conclusions</h3><div>This meta-analysis emphasizes the effect of neuropathic pain on anxiety- and depressive-like behaviors in rodents, highlighting the importance of investigating sex differences in future experimental studies.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100388"},"PeriodicalIF":4.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Mental Disorders in Donors and Matched Recipients of Hematopoietic Stem Cell Transplants: A Population-Based Cohort Study","authors":"Troels Boldt Rømer ,&nbsp;Henrik Sengeløv ,&nbsp;Rune Haubo Bojesen Christensen ,&nbsp;Michael Eriksen Benros","doi":"10.1016/j.bpsgos.2024.100389","DOIUrl":"10.1016/j.bpsgos.2024.100389","url":null,"abstract":"<div><h3>Background</h3><div>Immunological mechanisms have been implicated in the development of mental disorders, and interestingly, case reports have suggested that hematopoietic stem cell transplantation (HSCT) can both transmit and cure psychotic disorders by replacing immune progenitor cells.</div></div><div><h3>Methods</h3><div>Using Danish registers, we followed patients who received HSCT from donors with a psychiatric diagnosis or psychotropic medication use. We assessed risk of incident mental disorders or psychotropic medication use compared with recipients with unaffected donors. We identified 464 donor-recipient pairs (51.3% male recipients). All donor-recipient pairs were related.</div></div><div><h3>Results</h3><div>Receiving HSCT from a donor with a psychiatric history was not significantly associated with incident psychiatric diagnoses (hazard rate ratio [HRR] 2.79, 95% CI, 0.83–9.39; <em>p</em> = .098) or incident use of psychotropics (HRR 1.43, 95% CI, 0.91–2.24; <em>p</em> = .118). Subgroup analysis showed an increased risk of antipsychotic use, which remained significant after adjusting for confounders (HRR 4.73, 95% CI, 1.26–17.78; <em>p</em> = .021); however, this was based on a small number of cases. For depression and antidepressant use, data were available to perform a meta-analysis of our and one additional study, which showed no significant difference (HRR 1.24, 95%, CI 0.66–2.35).</div></div><div><h3>Conclusions</h3><div>Receiving HSCT from a donor with a psychiatric history did not affect risk of mental disorders. An increased risk of antipsychotic use was observed only in subgroup analyses; however, the exploratory nature of the study, the limited sample size, and family relationship between donors and recipients do not allow for causal conclusions, and external replication studies are warranted.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100389"},"PeriodicalIF":4.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Effects of Birth Weight on Longitudinal Behavioral Outcomes: A Mendelian Randomization Approach Using Polygenic Scores","authors":"Lars Meinertz Byg ,&nbsp;Carol Wang ,&nbsp;John Attia ,&nbsp;Andrew Whitehouse ,&nbsp;Craig Pennell","doi":"10.1016/j.bpsgos.2024.100387","DOIUrl":"10.1016/j.bpsgos.2024.100387","url":null,"abstract":"<div><h3>Background</h3><div>It is unclear whether sex differences in behavior arising from birth weight (BW) are genuine because of the cross-sectional nature and potential confounding in previous studies. We aimed to test whether sex differences associated with BW phenotype were reproducible using a Mendelian randomization approach, i.e., association between polygenic score (PGS) for BW and behavior outcomes across childhood and adolescence.</div></div><div><h3>Methods</h3><div>Using data from the Raine Study, we had 1484 genotyped participants with a total of 6446 Child Behavior Checklist assessments from ages 5 to 17 years. We used BW-PGSs in linear mixed-effect models to predict parentally assessed attention, aggression, and social problems scales; we also derived estimates and significance for a sex-by-genotype interaction. We used a Bonferroni-corrected significance threshold and tested robustness of the results with teacher assessments of behavior and a second PGS.</div></div><div><h3>Results</h3><div>We found a sex-by-genotype interaction with lower BW-PGSs associated with increased aggression in males compared with females. These findings were consistent across various analyses, including teacher assessments. Surprisingly, a lower BW-PGS showed protective effects in females, while a lower BW phenotype had detrimental effects in males with evidence of a genotype-phenotype mismatch increasing aggression problems in males only.</div></div><div><h3>Conclusions</h3><div>This study underscores the genuine nature of behavioral sex differences arising from low BW and highlights the sex-dependent and diverging effects of environmental and genetic BW determinants.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100387"},"PeriodicalIF":4.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of Posterior Default Mode Network Activity During Interoceptive Attention and Relation to Mindfulness","authors":"Dhakshin Ramanathan ,&nbsp;Jason Nan ,&nbsp;Gillian Grennan ,&nbsp;Satish Jaiswal ,&nbsp;Suzanna Purpura ,&nbsp;James Manchanda ,&nbsp;Vojislav Maric ,&nbsp;Pragathi Priyadharsini Balasubramani ,&nbsp;Jyoti Mishra","doi":"10.1016/j.bpsgos.2024.100384","DOIUrl":"10.1016/j.bpsgos.2024.100384","url":null,"abstract":"<div><h3>Background</h3><div>Interoceptive attention to internal sensory signals, such as the breath, is fundamental to mindfulness. However, interoceptive attention can be difficult to study, with many studies relying on subjective and retrospective measures. Response consistency is an established method for evaluating variability of attention on exteroceptive attention tasks, but it has rarely been applied to interoceptive attention tasks.</div></div><div><h3>Methods</h3><div>In this study, we measured consistency of response times on a breath-monitoring task with simultaneous electroencephalography in individuals across the life span (15–91 years of age, <em>N</em> = 324).</div></div><div><h3>Results</h3><div>We found that consistency on the breath-monitoring task was positively correlated with attentive performance on an exteroceptive inhibitory control task. Electroencephalography source reconstruction showed that on-task alpha band (8–12 Hz) activity was greater than that measured at rest. Low-consistency/longer breath responses were associated with elevated brain activity compared with high-consistency responses, particularly in posterior default mode network (pDMN) brain regions. pDMN activity was inversely linked with functional connectivity to the frontoparietal network and the cingulo-opercular network on task but not at rest, suggesting a role for these frontal networks in on-task regulation of pDMN activity. pDMN activity within the precuneus region was greater in participants who reported low subjective mindfulness and was adaptively modulated by task difficulty in an independent experiment.</div></div><div><h3>Conclusions</h3><div>Elevated pDMN alpha activity serves as an objective neural marker for low-consistency responding during interoceptive breath attention, scales with task difficulty, and is associated with low subjective mindfulness.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100384"},"PeriodicalIF":4.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resilience to Chronic Stress Is Characterized by Circadian Brain-Liver Coordination","authors":"Christina Savva ,&nbsp;Ivan Vlassakev ,&nbsp;Blynn G. Bunney ,&nbsp;William E. Bunney ,&nbsp;Lucas Massier ,&nbsp;Marcus Seldin ,&nbsp;Paolo Sassone-Corsi ,&nbsp;Paul Petrus ,&nbsp;Shogo Sato","doi":"10.1016/j.bpsgos.2024.100385","DOIUrl":"10.1016/j.bpsgos.2024.100385","url":null,"abstract":"<div><h3>Background</h3><div>Chronic stress has a profound impact on circadian regulation of physiology. In turn, disruption of circadian rhythms increases the risk of developing both psychiatric and metabolic disorders. To explore the role of chronic stress in modulating the links between neural and metabolic rhythms, we characterized the circadian transcriptional regulation across different brain regions and the liver as well as serum metabolomics in mice exposed to chronic social defeat stress, a validated model for studying depressive-like behaviors.</div></div><div><h3>Methods</h3><div>Male C57BL/6J mice underwent chronic social defeat stress, and subsequent social interaction screening identified distinct behavioral phenotypes associated with stress resilience and susceptibility. Stressed mice and their control littermates were sacrificed every 4 hours over the circadian cycle for comprehensive analyses of the circadian transcriptome in the hypothalamus, hippocampus, prefrontal cortex, and liver together with assessments of the circadian circulatory metabolome.</div></div><div><h3>Results</h3><div>Our data demonstrate that stress adaptation was characterized by reprogramming of the brain as well as the hepatic circadian transcriptome. Stress resiliency was associated with an increase in cyclic transcription in the hypothalamus, hippocampus, and liver. Furthermore, cross-tissue analyses revealed that resilient mice had enhanced transcriptional coordination of circadian pathways between the brain and liver. Conversely, susceptibility to social stress resulted in a loss of cross-tissue coordination. Circadian serum metabolomic profiles corroborated the transcriptome data, highlighting that stress-resilient mice gained circadian rhythmicity of circulating metabolites, including bile acids and sphingomyelins.</div></div><div><h3>Conclusions</h3><div>This study reveals that resilience to stress is characterized by enhanced metabolic rhythms and circadian brain-liver transcriptional coordination.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100385"},"PeriodicalIF":4.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667174324000983/pdfft?md5=0519555da8e37c473bb455fd9ff06ea4&pid=1-s2.0-S2667174324000983-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Prenatal Depression and Assessing Model Bias Using Machine Learning Models","authors":"Yongchao Huang ,&nbsp;Suzanne Alvernaz ,&nbsp;Sage J. Kim ,&nbsp;Pauline Maki ,&nbsp;Yang Dai ,&nbsp;Beatriz Peñalver Bernabé","doi":"10.1016/j.bpsgos.2024.100376","DOIUrl":"10.1016/j.bpsgos.2024.100376","url":null,"abstract":"<div><h3>Background</h3><div>Perinatal depression is one of the most common medical complications during pregnancy and postpartum period, affecting 10% to 20% of pregnant individuals, with higher rates among Black and Latina women who are also less likely to be diagnosed and treated. Machine learning (ML) models based on electronic medical records (EMRs) have effectively predicted postpartum depression in middle-class White women but have rarely included sufficient proportions of racial/ethnic minorities, which has contributed to biases in ML models. Our goal is to determine whether ML models could predict depression in early pregnancy in racial/ethnic minority women by leveraging EMR data.</div></div><div><h3>Methods</h3><div>We extracted EMRs from a large U.S. urban hospital serving mostly low-income Black and Hispanic women (<em>n</em> = 5875). Depressive symptom severity was assessed using the Patient Health Questionnaire-9 self-report questionnaire. We investigated multiple ML classifiers using Shapley additive explanations for model interpretation and determined prediction bias with 4 metrics: disparate impact, equal opportunity difference, and equalized odds (standard deviations of true positives and false positives).</div></div><div><h3>Results</h3><div>Although the best-performing ML model's (elastic net) performance was low (area under the receiver operating characteristic curve = 0.61), we identified known perinatal depression risk factors such as unplanned pregnancy and being single and underexplored factors such as self-reported pain, lower prenatal vitamin intake, asthma, carrying a male fetus, and lower platelet levels. Despite the sample comprising mostly low-income minority women (54% Black, 27% Latina), the model performed worse for these communities (area under the receiver operating characteristic curve: 57% Black, 59% Latina women vs. 64% White women).</div></div><div><h3>Conclusions</h3><div>EMR-based ML models could moderately predict early pregnancy depression but exhibited biased performance against low-income minority women.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100376"},"PeriodicalIF":4.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol Use Disorder–Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex","authors":"Julie D. White ,&nbsp;Melyssa S. Minto ,&nbsp;Caryn Willis ,&nbsp;Bryan C. Quach ,&nbsp;Shizhong Han ,&nbsp;Ran Tao ,&nbsp;Amy Deep-Soboslay ,&nbsp;Lea Zillich ,&nbsp;Stephanie H. Witt ,&nbsp;Rainer Spanagel ,&nbsp;Anita C. Hansson ,&nbsp;Shaunna L. Clark ,&nbsp;Edwin J.C.G. van den Oord ,&nbsp;Thomas M. Hyde ,&nbsp;R. Dayne Mayfield ,&nbsp;Bradley T. Webb ,&nbsp;Eric O. Johnson ,&nbsp;Joel E. Kleinman ,&nbsp;Laura J. Bierut ,&nbsp;Dana B. Hancock","doi":"10.1016/j.bpsgos.2024.100375","DOIUrl":"10.1016/j.bpsgos.2024.100375","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol use disorder (AUD) has a profound public health impact. However, understanding of the molecular mechanisms that underlie the development and progression of AUD remains limited. Here, we investigated AUD-associated DNA methylation changes within and across 2 addiction-relevant brain regions, the nucleus accumbens and dorsolateral prefrontal cortex.</div></div><div><h3>Methods</h3><div>Illumina HumanMethylation EPIC array data from 119 decedents (61 cases, 58 controls) were analyzed using robust linear regression with adjustment for technical and biological variables. Associations were characterized using integrative analyses of public annotation data and published genetic and epigenetic studies. We also tested for brain region–shared and brain region–specific associations using mixed-effects modeling and assessed implications of these results using public gene expression data from human brain.</div></div><div><h3>Results</h3><div>At a false discovery rate of ≤.05, we identified 105 unique AUD-associated CpGs (annotated to 120 genes) within and across brain regions. AUD-associated CpGs were enriched in histone marks that tag active promoters, and our strongest signals were specific to a single brain region. Some concordance was found between our results and those of earlier published alcohol use or dependence methylation studies. Of the 120 genes, 23 overlapped with previous genetic associations for substance use behaviors, some of which also overlapped with previous addiction-related methylation studies.</div></div><div><h3>Conclusions</h3><div>Our findings identify AUD-associated methylation signals and provide evidence of overlap with previous genetic and methylation studies. These signals may constitute predisposing genetic differences or robust methylation changes associated with AUD, although more work is needed to further disentangle the mechanisms that underlie these associations and their implications for AUD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"4 6","pages":"Article 100375"},"PeriodicalIF":4.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}