Biological psychiatry global open science最新文献

{"title":"α-Ketoglutarate Is a Circulatory Exercise Factor That Promotes Learning and Memory Recall and Has Antidepressant Properties","authors":"Fady Eid ,&nbsp;Perla El Ahmad ,&nbsp;Reine Khoury ,&nbsp;Diala El Masri ,&nbsp;Yara El Zoghby ,&nbsp;Yasmin Sahlloul ,&nbsp;Joanna Fadel ,&nbsp;Zena Haddad ,&nbsp;Amar Mezher ,&nbsp;Litsa Maria Ghayad ,&nbsp;Yorgo El Sabbagh ,&nbsp;Lea Gerges ,&nbsp;Mahmoud Lakis ,&nbsp;Christopher Sahyoun ,&nbsp;Ghinwa El Khoury ,&nbsp;Joseph S. Stephan ,&nbsp;Sama F. Sleiman","doi":"10.1016/j.bpsgos.2025.100477","DOIUrl":"10.1016/j.bpsgos.2025.100477","url":null,"abstract":"<div><h3>Background</h3><div>Depression poses a significant societal burden, necessitating effective treatment options. Conventional approaches often fall short, highlighting the need for alternatives. Exercise has emerged as a promising nonpharmacological strategy for improving mental health outcomes. Exercise promotes memory recall and alleviates depression by modulating BDNF (brain-derived neurotrophic factor) expression. The effects of exercise on BDNF are influenced by circulatory metabolites known as exercise factors.</div></div><div><h3>Methods</h3><div>Associative and spatial memory were evaluated in mice receiving α-ketoglutarate (aKG) and in exercise mice given a glutaminase inhibitor. To prevent and treat depression-like behaviors, male mice underwent daily defeat sessions by a CD1 aggressor for 10 days. Behavior was assessed on day 11 using social interaction and open-field tests. Mice received aKG for 5 days prior to the stress paradigm or as treatment for 14 days following the stress paradigm, after which social behavior was reassessed. BDNF signaling was examined via Western blots.</div></div><div><h3>Results</h3><div>aKG was identified as a metabolite released into the bloodstream following exercise in male mice. aKG was shown to mediate the positive effects of exercise on spatial learning and memory formation. aKG was also shown to have prophylactic and antidepressant effects in a chronic social defeat stress model of depression.</div></div><div><h3>Conclusions</h3><div>aKG acts as a prophylactic and antidepressant to effectively counteract social avoidance behaviors by modulating BDNF levels in the hippocampus and nucleus accumbens.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100477"},"PeriodicalIF":4.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrasting Individual-Specific Resilience and Compensation Personalization Frameworks: The Case of Rumination","authors":"Sigal Zilcha-Mano","doi":"10.1016/j.bpsgos.2025.100478","DOIUrl":"10.1016/j.bpsgos.2025.100478","url":null,"abstract":"<div><h3>Background</h3><div>Rumination has been identified as a potential mechanism of therapeutic change, particularly in directive and focused psychotherapies for depression. Previous research has predominantly focused on either trait-like individual differences or state-like changes in rumination without integrating these aspects. In the current study, we propose a computational approach to investigating whether rumination serves as a compensatory or a resilience mechanism by integrating trait-like and state-like effects.</div></div><div><h3>Methods</h3><div>Rumination and depressive symptoms were assessed (in <em>N</em> = 100) pretreatment and repeatedly throughout treatment. Mixed-level models were used to examine whether pretreatment trait-like rumination interacted with a time-variant variable of in-treatment state-like changes in rumination to predict subsequent changes in treatment outcomes. These models were used to determine whether individuals with higher or lower pretreatment trait-like levels of rumination benefited more from state-like reductions in rumination, thus contrasting the compensatory and resilience theoretical frameworks.</div></div><div><h3>Results</h3><div>As hypothesized, the findings supported the compensatory framework; individuals with higher pretreatment trait-like levels of rumination benefited most from greater state-like reductions in rumination during treatment, as evidenced by greater subsequent symptom reduction (<em>p</em> = .04).</div></div><div><h3>Conclusions</h3><div>The findings refine our understanding of rumination as an individual-specific mechanism of therapeutic change, dependent on an individual’s trait-like levels of rumination. The proposed computational approach enabled an empirical comparison of the 2 main theoretical frameworks of treatment personalization, compensatory and resilience, offering new insights into mechanisms that drive therapeutic change. Future studies could leverage the paradigm proposed here to examine for which patients and in what contexts mechanisms of change function as compensatory versus resilience mechanisms.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100478"},"PeriodicalIF":4.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2667-1743(25)00021-7","DOIUrl":"10.1016/S2667-1743(25)00021-7","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100467"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Neural Circuit Basis for the Sex-Specific Modulation of Binge Alcohol Drinking","authors":"Larry S. Zweifel","doi":"10.1016/j.bpsgos.2024.100444","DOIUrl":"10.1016/j.bpsgos.2024.100444","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100444"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Small Nucleolar RNAs Contribute to Neuropsychiatric Disorders? Insights and Future Perspectives","authors":"Yogesh Dwivedi","doi":"10.1016/j.bpsgos.2025.100447","DOIUrl":"10.1016/j.bpsgos.2025.100447","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100447"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2667-1743(25)00018-7","DOIUrl":"10.1016/S2667-1743(25)00018-7","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100464"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S2667-1743(25)00019-9","DOIUrl":"10.1016/S2667-1743(25)00019-9","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100465"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Insights Into the Neural Consequences of Synthetic Cannabinoids During Adolescence: The Critical Role of Reelin at Prefrontal Synapses","authors":"Giorgio Prosperi ,&nbsp;Antonia Manduca","doi":"10.1016/j.bpsgos.2025.100456","DOIUrl":"10.1016/j.bpsgos.2025.100456","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100456"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Many Roads to Irritability: How Developmental Change and Multiple Risk Pathways Can Impact Negative Findings in Resting-State Connectivity","authors":"Alecia C. Vogel,&nbsp;Kirsten E. Gilbert","doi":"10.1016/j.bpsgos.2025.100451","DOIUrl":"10.1016/j.bpsgos.2025.100451","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100451"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains","authors":"Micah A. Shelton ,&nbsp;Nicole Horan ,&nbsp;Xiangning Xue ,&nbsp;Lisa Maturin ,&nbsp;Darrell Eacret ,&nbsp;Julie Michaud ,&nbsp;Navsharan Singh ,&nbsp;Benjamin R. Williams ,&nbsp;Mackenzie C. Gamble ,&nbsp;Joseph A. Seggio ,&nbsp;Madeline K. Fish ,&nbsp;BaDoi N. Phan ,&nbsp;George C. Tseng ,&nbsp;Julie A. Blendy ,&nbsp;Leah C. Solberg Woods ,&nbsp;Abraham A. Palmer ,&nbsp;Olivier George ,&nbsp;Ryan W. Logan ,&nbsp;Marianne L. Seney","doi":"10.1016/j.bpsgos.2025.100476","DOIUrl":"10.1016/j.bpsgos.2025.100476","url":null,"abstract":"<div><h3>Background</h3><div>Opioid use disorder (OUD) has emerged as a severe, ongoing public health emergency. Current treatments for OUD are unsuccessful in leading to lasting abstinence in most users. This underscores the lasting effects of chronic opioid use and emphasizes the need to understand the molecular mechanisms of drug seeking and taking and how those alterations persist through acute and protracted withdrawal.</div></div><div><h3>Methods</h3><div>Here, we used RNA sequencing in postmortem human tissue from males (<em>n</em> = 10) and females (<em>n</em> = 10) with OUD and age- and sex-matched control subjects. We compared molecular alterations associated with human OUD in the nucleus accumbens (NAc) to mouse and rat models of nonvolitional (<em>n</em> = 4–5 per group per sex) and volitional (<em>n</em> = 5–6 per group per sex) exposure to opioids across distinct stages of opioid use and withdrawal (acute and prolonged).</div></div><div><h3>Results</h3><div>We found that the molecular signature in the NAc of females with OUD mirrored effects seen in the NAc of female rodents in a nonvolitional paradigm at all stages of exposure. Conversely, males with OUD showed an expression profile similar to that of rodents with volitional exposure but only during the acute withdrawal phase. Shared coexpression networks were involved in posttranscriptional modification of RNA and epigenetic modification of chromatin state.</div></div><div><h3>Conclusions</h3><div>Our results provide fundamental insight into the conserved molecular pathways altered by opioids across species, with evidence suggesting that alterations in females with OUD may be driven by drug exposure, while alterations in males with OUD may be driven by volitional intake.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100476"},"PeriodicalIF":4.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}