Biological psychiatry global open science最新文献

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2667-1743(25)00018-7","DOIUrl":"10.1016/S2667-1743(25)00018-7","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100464"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S2667-1743(25)00019-9","DOIUrl":"10.1016/S2667-1743(25)00019-9","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100465"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Insights Into the Neural Consequences of Synthetic Cannabinoids During Adolescence: The Critical Role of Reelin at Prefrontal Synapses","authors":"Giorgio Prosperi , Antonia Manduca","doi":"10.1016/j.bpsgos.2025.100456","DOIUrl":"10.1016/j.bpsgos.2025.100456","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100456"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Many Roads to Irritability: How Developmental Change and Multiple Risk Pathways Can Impact Negative Findings in Resting-State Connectivity","authors":"Alecia C. Vogel, Kirsten E. Gilbert","doi":"10.1016/j.bpsgos.2025.100451","DOIUrl":"10.1016/j.bpsgos.2025.100451","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 2","pages":"Article 100451"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains","authors":"Micah A. Shelton ,&nbsp;Nicole Horan ,&nbsp;Xiangning Xue ,&nbsp;Lisa Maturin ,&nbsp;Darrell Eacret ,&nbsp;Julie Michaud ,&nbsp;Navsharan Singh ,&nbsp;Benjamin R. Williams ,&nbsp;Mackenzie C. Gamble ,&nbsp;Joseph A. Seggio ,&nbsp;Madeline K. Fish ,&nbsp;BaDoi N. Phan ,&nbsp;George C. Tseng ,&nbsp;Julie A. Blendy ,&nbsp;Leah C. Solberg Woods ,&nbsp;Abraham A. Palmer ,&nbsp;Olivier George ,&nbsp;Ryan W. Logan ,&nbsp;Marianne L. Seney","doi":"10.1016/j.bpsgos.2025.100476","DOIUrl":"10.1016/j.bpsgos.2025.100476","url":null,"abstract":"<div><h3>Background</h3><div>Opioid use disorder (OUD) has emerged as a severe, ongoing public health emergency. Current treatments for OUD are unsuccessful in leading to lasting abstinence in most users. This underscores the lasting effects of chronic opioid use and emphasizes the need to understand the molecular mechanisms of drug seeking and taking and how those alterations persist through acute and protracted withdrawal.</div></div><div><h3>Methods</h3><div>Here, we used RNA sequencing in postmortem human tissue from males (<em>n</em> = 10) and females (<em>n</em> = 10) with OUD and age- and sex-matched control subjects. We compared molecular alterations associated with human OUD in the nucleus accumbens (NAc) to mouse and rat models of nonvolitional (<em>n</em> = 4–5 per group per sex) and volitional (<em>n</em> = 5–6 per group per sex) exposure to opioids across distinct stages of opioid use and withdrawal (acute and prolonged).</div></div><div><h3>Results</h3><div>We found that the molecular signature in the NAc of females with OUD mirrored effects seen in the NAc of female rodents in a nonvolitional paradigm at all stages of exposure. Conversely, males with OUD showed an expression profile similar to that of rodents with volitional exposure but only during the acute withdrawal phase. Shared coexpression networks were involved in posttranscriptional modification of RNA and epigenetic modification of chromatin state.</div></div><div><h3>Conclusions</h3><div>Our results provide fundamental insight into the conserved molecular pathways altered by opioids across species, with evidence suggesting that alterations in females with OUD may be driven by drug exposure, while alterations in males with OUD may be driven by volitional intake.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100476"},"PeriodicalIF":4.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Data-Driven Subtypes of Depression Informed by Clinical and Neuroimaging Data: A Registered Report","authors":"Kayla Hannon ,&nbsp;Setthanan Jarukasemkit ,&nbsp;Leda Balogh ,&nbsp;Fyzeen Ahmad ,&nbsp;Petra Lenzini ,&nbsp;Aristeidis Sotiras ,&nbsp;Janine D. Bijsterbosch","doi":"10.1016/j.bpsgos.2025.100473","DOIUrl":"10.1016/j.bpsgos.2025.100473","url":null,"abstract":"<div><h3>Background</h3><div>Efforts to elucidate subtypes within depression have yet to establish a consensus. In this study, we aimed to rigorously compare different subtyping approaches in the same participant space to quantitatively test agreement across subtyping approaches and determine whether the different approaches are sensitive to different sources of heterogeneity in depression.</div></div><div><h3>Methods</h3><div>We implemented 6 different data-driven subtyping methods developed in previous work using the same UK Biobank participants (<em>n</em> = 2276 participants with depression, <em>n</em> = 1595 healthy control participants). The 6 approaches include 2 symptom-based, 2 structural neuroimaging–based, and 2 functional neuroimaging–based techniques. The resulting subtypes were compared based on participant assignment, stability, and sensitivity to subtype differences in demographics, general health, clinical characteristics, neuroimaging, trauma, cognition, genetics, and inflammation markers.</div></div><div><h3>Results</h3><div>We found almost no agreement between the resulting subtypes of the 6 approaches (mean adjusted Rand index [ARI] = 0.006), even within data domains. This finding was largely driven by differences in input feature set (mean ARI = 0.005) rather than clustering algorithm (mean ARI = 0.23). However, each approach had relatively high internal stability across bootstraps (ARI = 0.36–0.89); most approaches performed above null; and most approaches were sensitive to relevant phenotypes within their data domain.</div></div><div><h3>Conclusions</h3><div>Despite marginal overlap between approaches, we found the subtyping approaches to be internally consistent. These results explain why previous studies found strong evidence for subtypes within their analysis but with very little convergence between studies. We recommend that in future work, investigators incorporate systematic comparisons between their approach and alternative/previous approaches to facilitate consensus on depression subtypes.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100473"},"PeriodicalIF":4.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shedding Light on Changes in Subjective Experience During an Intensive Contemplative Retreat: The Lyon Assessment of Meditation Phenomenology Questionnaire","authors":"Oussama Abdoun ,&nbsp;Arnaud Poublan-Couzardot ,&nbsp;Stéphane Offort ,&nbsp;Giuseppe Pagnoni ,&nbsp;Antoine Lutz","doi":"10.1016/j.bpsgos.2025.100474","DOIUrl":"10.1016/j.bpsgos.2025.100474","url":null,"abstract":"<div><h3>Background</h3><div>A significant share of meditation research relies on trait psychometric measures of mindfulness, which neglect the complex and dynamic unfolding of experiential processes entailed by meditation over time. However, there have been a few attempts to capture ongoing changes in experience during meditation. In this study, we integrated and expanded on 3 of these previous approaches to create a novel instrument, which we called the Lyon Assessment of Meditation Phenomenology (LAMP). This questionnaire encompasses contextual, conative, affective, somatic, attentional, cognitive, and metacognitive domains.</div></div><div><h3>Methods</h3><div>Fifty-three experienced meditators completed the LAMP after each meditation session during an intensive 10-day retreat. We modeled the time courses of the individual answers to each question using generalized additive modeling and automatically clustered participants using group-based trajectory modeling.</div></div><div><h3>Results</h3><div>Over 60% of the dimensions assessed by LAMP exhibited significant change during the retreat across the group, following distinct temporal trajectories. These trajectories reflected differences between meditation types (chiefly, focused attention and open monitoring) and individual expertise, supporting a previously proposed multidimensional phenomenological model of mindfulness-related practices. We also identified 3 clusters of individual temporal trajectories associated with prior meditative experience and difficulties experienced during the retreat. Finally, we replicated and extended core findings from mindfulness research on pain regulation.</div></div><div><h3>Conclusions</h3><div>The proposed multidimensional experience-sampling approach provides a rich characterization of the dynamic aspects of meditative experience and may be used to deepen our knowledge of the phenomenology and mechanisms of meditation and meditation-based interventions.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 4","pages":"Article 100474"},"PeriodicalIF":4.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Frequency for Seizure Induction With Electroconvulsive Therapy and Magnetic Seizure Therapy in Nonhuman Primates","authors":"Angel V. Peterchev ,&nbsp;Zhi-De Deng ,&nbsp;Christopher Sikes-Keilp ,&nbsp;Elyssa C. Feuer ,&nbsp;Moacyr A. Rosa ,&nbsp;Sarah H. Lisanby","doi":"10.1016/j.bpsgos.2025.100471","DOIUrl":"10.1016/j.bpsgos.2025.100471","url":null,"abstract":"<div><h3>Background</h3><div>Electroconvulsive therapy (ECT) and magnetic seizure therapy (MST) are effective in the treatment of medication-resistant depression. Determining the stimulus frequency that results in the lowest seizure threshold could produce fewer adverse effects by reducing the overall stimulus intensity.</div></div><div><h3>Methods</h3><div>To determine the optimal frequency for seizure induction, 4 male rhesus macaques were titrated with an increasing number of pulses at fixed frequencies ranging from 5 to 240 pulses per second (pps) using ultrabrief pulse right-unilateral ECT and circular-coil-on-vertex MST. Bilateral electroencephalography was recorded to characterize the seizure expression.</div></div><div><h3>Results</h3><div>The seizure threshold dependence on stimulus frequency was similar for ECT and MST. While higher frequencies required progressively shorter trains to induce a seizure, the middle frequency range was associated with the fewest pulses (and therefore the least charge and energy), with a minimum at 16 pps and similarly low thresholds for 10 and 25 pps. The number of pulses at seizure threshold increased markedly at lower and higher frequencies. The lowest stimulus frequencies, 5 and 10 pps, were associated with the greatest ictal power measured by electroencephalography.</div></div><div><h3>Conclusions</h3><div>While neither efficacy nor side effects were assessed in this study, the results highlight the significance of stimulus frequency for seizure induction, suggest efficient titration schedules that minimize exposure to the electrical stimulus, and can inform studies to assess the impact on clinical outcomes. These data can also support safety guidelines for interventions such as transcranial magnetic stimulation that must avoid seizure induction.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100471"},"PeriodicalIF":4.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143696217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable White Matter Structure in the First Three Years After Psychosis Onset","authors":"Peter C. Van Dyken ,&nbsp;Kun Yang ,&nbsp;Andreia V. Faria ,&nbsp;Akira Sawa ,&nbsp;Michael MacKinley ,&nbsp;Ali R. Khan ,&nbsp;Lena Palaniyappan","doi":"10.1016/j.bpsgos.2025.100472","DOIUrl":"10.1016/j.bpsgos.2025.100472","url":null,"abstract":"<div><h3>Background</h3><div>White matter alterations observed using diffusion weighted imaging have become a hallmark of chronic schizophrenia, but it is unclear when these changes arise over the course of the disease. Nearly all studies reported to date have been cross-sectional, so despite their large sample sizes, they cannot determine whether changes accumulate as a degenerative process or patients with preexisting white matter damage are predisposed to more chronic forms of schizophrenia.</div></div><div><h3>Methods</h3><div>We examined 160 scans comprising 2 years of annual follow-up data from 42 control participants and 28 patients with schizophrenia recruited in the first 2 years since their diagnosis, totaling 2 to 3 scans per participant. We also examined 6-month follow-up data obtained from an ultra-high field (7T) scanner (68 scans; <em>n</em> = 19 patients with first-episode schizophrenia, <em>n</em> = 15 control participants) as a validation dataset. A longitudinal model was used to compare the trajectory of diffusion tensor parameters in patients and control participants.</div></div><div><h3>Results</h3><div>Positive and negative symptom scores were correlated with diffusion parameters using region of interest-based approaches. No longitudinal differences between patients and control participants were observed for any diffusion tensor imaging parameter in either dataset. However, we did observe consistent associations between white matter alterations and negative symptoms in both datasets.</div></div><div><h3>Conclusions</h3><div>White matter does not appear to be susceptible to schizophrenia-linked degeneration in the early stages of disease, but preexisting pathology may be linked to disease severity.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100472"},"PeriodicalIF":4.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Polygenic Risk Scores and Treatment Response to Antidepressants, Benzodiazepines, and Antihistamines in Anxiety and Depression","authors":"Amelie Markant ,&nbsp;Fara Tabrizi ,&nbsp;Hampus Grönvall ,&nbsp;Doug Speed ,&nbsp;Fredrik Åhs","doi":"10.1016/j.bpsgos.2025.100470","DOIUrl":"10.1016/j.bpsgos.2025.100470","url":null,"abstract":"<div><h3>Background</h3><div>Anxiety and depression are the most prevalent mental health disorders. The first-line treatment is antidepressants, such as serotonin reuptake inhibitors, but benzodiazepines and antihistamines are also used to treat anxiety. Only one-third of patients achieve remission with first-line treatment. Identifying responders and nonresponders to monotherapy prior to treatment could increase remission rates and reduce dropout. The aim of the current study was to predict response to antidepressants, benzodiazepines, and antihistamines from polygenic risk scores (PRSs) in individuals with anxiety and/or depression symptoms.</div></div><div><h3>Methods</h3><div>We identified 2515 individuals in a genotyped cohort in the Swedish Twin Registry who had been prescribed drugs for anxiety and/or depression. Of these individuals, 1037 received monotherapy (555 with antidepressants, 169 with benzodiazepines, and 313 with antihistamines). The remaining 1478 individuals switched or added more drugs during the assessment period (2005–2018). The accuracy of 42 PRSs for psychiatric diagnoses as well as for nonclinical phenotypes in predicting mono- versus multitherapy was assessed using logistic regression.</div></div><div><h3>Results</h3><div>Monotherapy with benzodiazepines was predicted by a PRS for depressive symptoms indexed by the Patient Health Questionnaire (odds ratio [OR] = 1.29), while monotherapy with antihistamines was predicted by a PRS for lifetime anxiety disorder (OR = 1.25) and a PRS for schizophrenia (OR = 1.24). None of the investigated PRSs significantly predicted monotherapy with antidepressants.</div></div><div><h3>Conclusions</h3><div>Real-world data suggest that monotherapy with benzodiazepines or antihistamines can be predicted from PRSs related to anxiety, depression, and schizophrenia.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 3","pages":"Article 100470"},"PeriodicalIF":4.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}