American heart journal plus : cardiology research and practice最新文献

{"title":"The association of pre-diabetes with significant coronary artery disease and ischemic mitral regurgitation in patients with non-ST-segment elevation acute coronary syndrome","authors":"Maryam Nabati ,&nbsp;Younes Zeytounli ,&nbsp;Farima Sadat Mousavi ,&nbsp;Jamshid Yazdani ,&nbsp;Homa Parsaee","doi":"10.1016/j.ahjo.2025.100614","DOIUrl":"10.1016/j.ahjo.2025.100614","url":null,"abstract":"<div><h3>Background</h3><div>Pre-diabetes is associated with an increased risk of developing cardiovascular disease (CVD). We aimed to investigate the association between pre-diabetes and the severity of coronary artery disease, along with other high-risk markers—such as ischemic mitral regurgitation (MR)—in non-diabetic patients hospitalized with NSTE-ACS.</div></div><div><h3>Methods</h3><div>This study was a case control study on 200 non-diabetic patients including equal size of consecutive pre-diabetic and normoglycemic individuals with NSTE-ACS. All patients underwent an echocardiography to determine the left ventricular ejection fraction, prevalence and existence of ischemic mitral regurgitation (MR), and right ventricular size and function. After that, coronary angiography (CAG) was performed to assess the significance of coronary artery disease (CAD) and to calculate the SYNTAX score.</div></div><div><h3>Results</h3><div>pre-diabetic patients were older and had higher prevalence of hypertension than normoglycemic group (<em>P</em> value&lt;0.001 and 0.001, respectively). Also, significant CAD (86 % vs. 74 %, P value = 0.034) and severe ischemic MR (16 % vs. 6 %, P value = 0.024) were more prevalent in pre-diabetic patients than in normoglycemic patients, whereas the absence of MR was more common in normoglycemic patients (21 % vs. 3 %, <em>P</em> value &lt;0.001). The logistic regression analysis showed the association between significant CAD and pre-diabetes was independent of other variables (<em>P</em> value = 0.049, odds ratio [OR]: 2.402, 95 % CI: 1.005–5.741).</div></div><div><h3>Conclusions</h3><div>In our study, severe CAD and ischemic MR were more prevalent in pre-diabetic patients than normoglycemic ones that may be indicative of pre-diabetes as a high risk state in NSTE-ACS.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100614"},"PeriodicalIF":1.8,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new formula for evaluating culprit lesion characteristics in STEMI patients based on baseline","authors":"Rui Gao ,&nbsp;Qi Liu ,&nbsp;Jingbo Hou","doi":"10.1016/j.ahjo.2025.100616","DOIUrl":"10.1016/j.ahjo.2025.100616","url":null,"abstract":"<div><h3>Background</h3><div>Acute myocardial infarction is a leading cause of death worldwide. ST-segment elevated myocardial infarction patients exhibit different plaque morphology depending on many factors. However, the development of pathological states should not be attributed to a single factor alone. Therefore, a new formula is needed to comprehensively predict plaque characteristics to improve patient risk stratification and enable precision management.</div></div><div><h3>Methods</h3><div>This study include patients first diagnosed ST-segment elevation myocardial infarction who underwent optical coherence tomography before the intervention. NGSA2/P2 = ln ((non-high-density lipoprotein cholesterol / high-density lipoprotein cholesterol)*Glycosylated hemoglobin * admission systolic blood pressure * (Age)²/(platelet count)²) and further divided into three groups, T0 (&lt;4.315), T1(≥4.315, &lt;5.340), T3(≥5.340).</div></div><div><h3>Results</h3><div>A total of 268 patients were analyzed. Compared to the plaque erosion patients, the plaque rupture patients were older, had lower platelet counts, a higher prevalence of multi-vessel disease, and significantly higher levels of NGSA2/P2. Plaque rupture was positively correlated with age and NGSA2/P2 values, and negatively correlated with platelet counts. Compared to T0 group, the T1 and T2 groups had more cholesterol crystals, macrophages, thin-cap fibroatheromas, smaller normal°, greater lipid-rich° and lipid core index.</div></div><div><h3>Conclusions</h3><div>The new formula NGSA2/P2 integrates multiple indicators and provides superior predictions of plaque characters compared to the observation single factor. For older patients, it may be particularly important to strengthen the regulation of lipids, blood pressure, blood glucose, and platelet counts.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100616"},"PeriodicalIF":1.8,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic valve replacement in patients with significant aortic regurgitation: Comparing bicuspid and tricuspid aortic valve outcomes","authors":"Ching-Yan Zhu ,&nbsp;Jing-Nan Zhang ,&nbsp;Ferit Böyük ,&nbsp;Yi-Kei Tse ,&nbsp;Yan Chen ,&nbsp;Mei-Zhen Wu ,&nbsp;Qing-Wen Ren ,&nbsp;Jia-Yi Huang ,&nbsp;Ran Guo ,&nbsp;Wen-Li Gu ,&nbsp;Daniel Tai-Leung Chan ,&nbsp;Frank A. Flachskampf ,&nbsp;Kai-Hang Yiu","doi":"10.1016/j.ahjo.2025.100617","DOIUrl":"10.1016/j.ahjo.2025.100617","url":null,"abstract":"<div><h3>Background</h3><div>The role of bicuspid aortic valve (BAV) morphology in left ventricular (LV) remodelling and outcomes in aortic regurgitation (AR) patients undergoing surgical aortic valve replacement (SAVR) remains unclear. This study compares LV function and postoperative outcomes in patients with moderate-to-severe AR, stratified by BAV versus tricuspid aortic valve (TAV) morphology.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 323 patients with isolated moderate-to-severe AR undergoing SAVR (BAV: <em>n</em> = 70; TAV: <em>n</em> = 253). Baseline clinical, echocardiographic, surgical, and follow-up data were evaluated. Adverse events were defined as a composite of all-cause mortality and heart failure rehospitalization.</div></div><div><h3>Results</h3><div>Patients with BAV were a decade younger, were less symptomatic, but had smaller indexed aortic valve areas (AVAi) and greater regurgitant volumes. Patients with BAV had greater rise in indexed stroke volumes (SVi) with rising indexed LV end-diastolic volumes (LVEDVi) (p_interaction = 0.008), and milder LV ejection fraction decline with increasing LV end-systolic diameter (LVESD) (p_interaction = 0.004). Patients with BAV experienced less adverse events (16 % vs 30 %, <em>p</em> = 0.014). AVAi and indexed LV mass (LVMi) independently predicted adverse events after multivariable adjustment and age-matching, while valve morphology did not.</div></div><div><h3>Conclusion</h3><div>In patients requiring SAVR for isolated AR, patients with BAV had more severe valve dysfunction at a younger age but more preserved systolic function with LV dilation. AVAi and LVMi independently predict postoperative outcomes, supporting their use for risk stratification and timely intervention, especially in younger BAV patients.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100617"},"PeriodicalIF":1.8,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous closure of patent foramen ovale with complex anatomy using the Memopart™ occluder device","authors":"S. Gili,&nbsp;F. Cannata,&nbsp;M. Muratori,&nbsp;G. Santagostino Baldi,&nbsp;G. Teruzzi,&nbsp;G. Calligaris,&nbsp;D. Trabattoni","doi":"10.1016/j.ahjo.2025.100613","DOIUrl":"10.1016/j.ahjo.2025.100613","url":null,"abstract":"<div><div>We conducted a single center observational study aimed to assess safety and efficacy of Balmed Memopart PFO occluder in treatment of complex PFO anatomies including at least one of the following: tunnel length ≥ 8 mm, atrial septal aneurysm, lipomatous hypertrophy of fossa ovalis rims (≥10 mm), cribriform or additional multiple small defects on the fossa ovalis, residual large Eustachian ridge or Chiari network. This analysis demonstrated Memopart PFO occluder device to be a safe and effective option for PFO closure, with good procedural success rate (100 %) and no significant safety issues (1 mild residual shunt at 24 h).</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100613"},"PeriodicalIF":1.8,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk factor burden and adverse pregnancy outcomes in women with cardiovascular disease","authors":"Valerie C. Nemov ,&nbsp;Alden Dunham ,&nbsp;Claudio Schenone Giugni ,&nbsp;Viviana De Assis ,&nbsp;Emily Coughlin ,&nbsp;Mary Ashley Cain ,&nbsp;Judette M. Louis ,&nbsp;Daniela R. Crousillat","doi":"10.1016/j.ahjo.2025.100611","DOIUrl":"10.1016/j.ahjo.2025.100611","url":null,"abstract":"<div><h3>Introduction</h3><div>We investigated associations between pre-conception cardiovascular risk factor burden and adverse pregnancy outcomes (APOs) in women with cardiovascular disease (CVD).</div></div><div><h3>Methods</h3><div>We created a patient registry from our cardio-obstetrics program. APOs were defined as intrauterine growth restriction (IUGR), hypertensive disorder of pregnancy (HDP), and pre-term birth.</div></div><div><h3>Results</h3><div>Analysis included 63 women. 42 (66.7 %) experienced no APOs, while 21 (33.3 %) did; 18 (28.6 %), 3 (4.8 %), and 12 (19.0 %) developed an HDP, IUGR, or delivered pre-term, respectively. Pre-conception risk burden was not a significant predictor of APO development (<em>p</em> <em>=</em> 0.139). However, patients with pre-term delivery had a significantly higher number of risk factors (<em>p</em> &lt; 0.001), as did patients with chronic hypertension with superimposed HDP (<em>p</em> &lt; 0.001).</div></div><div><h3>Discussion</h3><div>Women delivering pre-term have higher risk factor burdens. Since pre-term birth is associated with future CVD in women independent of cause, optimization of preconception cardiovascular health could help mitigate these risks in an already vulnerable population.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100611"},"PeriodicalIF":1.8,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct oral anticoagulants versus low-molecular-weight heparin for thromboprophylaxis in cancer-related surgeries: A meta-analysis of efficacy and safety outcomes","authors":"Asma Mousavi ,&nbsp;Shayan Shojaei ,&nbsp;Parham Dastjerdi ,&nbsp;Soheil Rahmati ,&nbsp;Kasra Izadpanahi ,&nbsp;Homayoun Pishraft-sabet ,&nbsp;Elmira Jafari Afshar ,&nbsp;Keyvan Salehi ,&nbsp;Mahshad Sabri ,&nbsp;Mahsa Noohi Arbatan ,&nbsp;Parisa Fallahtafti ,&nbsp;Aronow Wilbert ,&nbsp;Andrew P. Ambrosy ,&nbsp;Mushabbar A. Syed ,&nbsp;Mina Iskander ,&nbsp;Kaveh Hosseini","doi":"10.1016/j.ahjo.2025.100607","DOIUrl":"10.1016/j.ahjo.2025.100607","url":null,"abstract":"<div><h3>Background</h3><div>Post-operative venous thromboembolism (VTE) remains a concern following cancer-related surgeries. This systematic review and meta-analysis aimed to evaluate the safety and efficacy of direct oral anticoagulants (DOACs) compared to low molecular weight heparin (LMWH) for thromboprophylaxis after cancer-related surgeries.</div></div><div><h3>Methods</h3><div>We systematically searched databases for studies comparing DOACs to LMWH for post-operative thromboprophylaxis in patients undergoing cancer-related surgeries. Primary outcomes were VTE incidence and bleeding events. Secondary outcomes included all-cause mortality and hospitalization rates. Subgroup analyses examined DOAC type, cancer type, and follow-up duration. A random-effects model calculated pooled risk ratios (RRs) with 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>Analysis included 16 studies with 6400 participants in the DOAC group (mean age 62.05 years, 28.15 % male) and 5801 participants in the LMWH group (mean age 60.78 years, 34.65 % male). DOACs were non-inferior to LMWH for VTE prevention (RR = 0.81, 95 % CI 0.56 to 1.16) with no significant difference in bleeding rates (RR = 0.70, 95 % CI 0.70 to 1.18). Mortality and hospitalization rates were similar between groups. Subgroup analyses suggested possible VTE reduction with DOACs in urological cancer surgeries (RR = 0.52, 95 % CI 0.44 to 0.61) and lower bleeding trends with Apixaban (RR = 0.64, 95 % CI 0.44 to 0.94).</div></div><div><h3>Conclusions</h3><div>DOACs appear non-inferior to LMWH for post-operative thromboprophylaxis in patients undergoing cancer-related surgeries, with comparable safety. The superior VTE prevention in urological cancer surgeries and Apixaban's favorable safety profile warrant further investigation. Moreover, additional research is necessary to clarify the roles of specific DOACs and optimal prophylaxis strategies across various cancer types and surgical procedures.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100607"},"PeriodicalIF":1.8,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous retrieval of a fractured coronary catheter: A case report","authors":"Chengli Tao ,&nbsp;Aixia Zhou ,&nbsp;Shuang Wu ,&nbsp;Xiaohui Chang","doi":"10.1016/j.ahjo.2025.100608","DOIUrl":"10.1016/j.ahjo.2025.100608","url":null,"abstract":"<div><h3>Background</h3><div>Intravascular angiographic catheter fracture is an extremely rare but critical complication of percutaneous coronary intervention (PCI). Conventional retrieval strategies (e.g., surgical intervention, snares) may prolong procedures and raise peri-procedural complication risks. Herein, we report a case of successful retrieval of a fractured catheter using an innovative technique.</div></div><div><h3>Case presentation</h3><div>A 59-year-old female with 7-year hypertension was admitted for 3-month recurrent exertional angina. Right radial coronary angiography was performed, during which a TIG catheter fractured ∼8 cm proximal to the ulnar-radial bifurcation in the right brachial artery. Initial attempts to retrieve it via a Runthrough NS guidewire failed.</div><div>To retrieve the fragment, we sequentially advanced JR3.5, 6FBL3.0, and 6FJR3.5 guiding catheters via the right radial arterial sheath to the proximal stump, then tried advancing a Cross-IT XTR guidewire along them—this maneuver remained unsuccessful.</div><div>Subsequently, an inferior vena cava (IVC) filter retriever via the right radial sheath failed to snare the proximal stump. We then constructed a custom snare by looping a Runthrough NS guidewire at an extension catheter tip, and retrieved the fragment via balloon-assisted counter-traction.</div><div>Postoperatively, the patient was stable without complications. Dual antiplatelet therapy and follow-up were initiated, with no adverse events at 1-month follow-up.</div></div><div><h3>Conclusion</h3><div>This minimally invasive technique obviates surgery, shows promise for intravascular foreign body management, and provides insights for adapting to failed conventional strategies in complex cases.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100608"},"PeriodicalIF":1.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of coronary artery disease involvement in patients with or without familial history","authors":"Ramin Khameneh Bagheri ,&nbsp;Hosna Hosseini Moghaddam ,&nbsp;Mostafa Ahmadi ,&nbsp;Ali Eshraghi ,&nbsp;Maryam Emadzadeh ,&nbsp;Faeze Keihanian ,&nbsp;Aida Yavari Kondori","doi":"10.1016/j.ahjo.2025.100609","DOIUrl":"10.1016/j.ahjo.2025.100609","url":null,"abstract":"<div><h3>Introduction</h3><div>Family history (FH) and genetic factors contribute significantly to coronary artery disease (CAD) risk. Given limited data on this association in the Iranian population, this study assessed CAD involvement patterns among patients with and without positive familial history.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted from April 2019 to April 2020 at <em>Imam</em> Reza and Ghaem Hospitals, Mashhad, Iran. We enrolled 300 patients who presented with typical chest pain and confirmed CAD via coronary angiography. Participants were divided into two groups based on FH of CAD and evaluated for potential risk factors.</div></div><div><h3>Results</h3><div>Of 300 patients, 170 had positive FH and 130 did not. The cohort included 175 males (58.3 %) with a mean age of 54.2 years. Multivariate logistic regression identified age (OR: 1.04, <em>p</em> = 0.014), male gender (OR: 0.56, <em>p</em> = 0.035), and hypertension (OR: 1.99, <em>p</em> = 0.008) as significant differentiators between FH groups. Positive FH was independently associated with more extensive CAD, including multivessel involvement and greater severity of disease.</div></div><div><h3>Conclusion</h3><div>Positive familial history is strongly associated with increased severity and extent of CAD in Iranian patients. Incorporating FH into risk stratification can improve identification of high-risk individuals for targeted preventive and therapeutic strategies.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100609"},"PeriodicalIF":1.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesterol crystal embolization syndrome: Systemic and end-organ injury","authors":"Akanksha Mehla ,&nbsp;Yash Patel ,&nbsp;Majid Yavari ,&nbsp;Mahmoud Khairy ,&nbsp;Kevin Watat ,&nbsp;F.N.U. Parul ,&nbsp;Karuna Rayamajhi ,&nbsp;Britni Smith ,&nbsp;George S. Abela ,&nbsp;Christopher A. Hanson","doi":"10.1016/j.ahjo.2025.100612","DOIUrl":"10.1016/j.ahjo.2025.100612","url":null,"abstract":"<div><div>Cholesterol embolization syndrome (CES) is characterized by the embolization of cholesterol crystals from atherosclerotic plaques into small and medium-size arteries. It predominantly occurs spontaneously in individuals with severe atherosclerosis or following vascular interventions. The dislodgment of cholesterol crystals triggers an inflammatory cascade in the affected vessels, leading to tissue ischemia and multi-organ dysfunction. Commonly affected are the kidneys, skin, and gastrointestinal tract, although any affected, though any organ system may be involved with varied presentations often making the diagnosis challenging. CES is diagnosed based on clinical suspicion supported by laboratory findings, such as eosinophilia, elevated inflammatory markers, imaging and/or histopathological evidence of cholesterol emboli. Treatment focuses on supportive care, addressing end-organ damage, and minimizing further embolization by optimizing atherosclerotic risk factors. Anticoagulation is generally avoided unless there is an alternative indication. Statins are commonly used for their pleiotropic effects on inflammation and plaque stabilization. In conclusion, CES is an underrecognized condition with significant morbidity. A high index of suspicion is essential for early diagnosis and intervention.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100612"},"PeriodicalIF":1.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Woven solutions for tissue engineering: Next-generation heart valves from fiber to function","authors":"Cornelia Sennewald ,&nbsp;Jasmin Pilgrim ,&nbsp;Dilbar Aibibu ,&nbsp;Thomas Gereke ,&nbsp;Philipp Schegner ,&nbsp;Chokri Cherif","doi":"10.1016/j.ahjo.2025.100604","DOIUrl":"10.1016/j.ahjo.2025.100604","url":null,"abstract":"<div><h3>Study objective</h3><div>Cardiovascular diseases remain one of the leading causes of morbidity and mortality worldwide, yet the availability of durable, patient-specific heart valve replacements is still limited. The aim is to utilize a biomimetic, textile-based design to mimic natural tissues, thereby creating customizable solutions with improved mechanical properties and scalable production for cardiovascular applications.</div></div><div><h3>Design</h3><div>By leveraging advanced 3D weaving techniques, the feasibility of manufacturing anatomically adaptable and mechanically robust textile valves is demonstrated. CAD-based design workflows and functional materials such as shape memory Nitinol wires are part of this technology. The integration of form-defining geometries, multilayer structures and functional surface treatments is enabled through tailored binding design and machine adaptations.</div></div><div><h3>Main outcome and results</h3><div>A textile-based heart valve implant was developed using advanced 3D weaving, CAD modelling and patient-specific imaging. Integrated leaflets and an annular ring were formed directly during weaving using mold inserts and multilayer structures, eliminating post-processing. Polyester and Nitinol materials provided mechanical stability and shape-memory functionality. Simulation models and SPH analysis validated pressure behaviour and deformation under physiological conditions. Functional zones with tailored stiffness, sealing and mobility were realized through binding variation and Jacquard control. A reproducible digital workflow, from CT segmentation to weaving on modified looms, enabled scalable production of anatomically accurate, functionally optimized heart valve prostheses. Mechanical evaluations reveal favourable performance in comparison to conventional valve designs.</div></div><div><h3>Conclusion</h3><div>These findings highlight the potential of fiber and textile technology as a scalable, customizable clinically relevant platform for heart valve tissue engineering and future biomedical applications.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100604"},"PeriodicalIF":1.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}