American heart journal plus : cardiology research and practice最新文献

{"title":"Association of the triglyceride–glucose index with all-cause and cause-specific mortality in patients with comorbid hypertension and diabetes: A population-based cohort study","authors":"Jiahao Zou ,&nbsp;Song Lu ,&nbsp;Kaishen Cao ,&nbsp;Ruihong He ,&nbsp;Xia Feng ,&nbsp;Shuang Yang ,&nbsp;Wen Liu ,&nbsp;Haochen Liu ,&nbsp;Zhichao Wang ,&nbsp;Ruichun Liao ,&nbsp;Jin Chen ,&nbsp;Xiaoting Jiang ,&nbsp;Xiaoping Peng","doi":"10.1016/j.ahjo.2025.100657","DOIUrl":"10.1016/j.ahjo.2025.100657","url":null,"abstract":"<div><h3>Study objective</h3><div>Although the triglyceride-glucose (TyG) index has been shown to be an independent risk factor for either hypertension or diabetes, its association with the coexistence of both conditions remains unclear. This study aimed to evaluate the association between the TyG index and all-cause and cause-specific mortality among patients with comorbid hypertension and diabetes.</div></div><div><h3>Design</h3><div>To elucidate the correlation between the TyG index and various modes of death, three multifactorial Cox proportional risk regression models were constructed. Restricted cubic spline curves are utilised to fit dose–response associations with the TyG index and various mortality rates. The effect of the TyG index threshold on different types of mortality was assessed via a two-stage Cox regression model.</div></div><div><h3>Participants</h3><div>The current study included 3222 patients from the National Health and Nutrition Examination Survey with hypertension combined with diabetes mellitus.</div></div><div><h3>Main outcome measures</h3><div>The endpoints of interest were all-cause death, cardiovascular death, and diabetes death.</div></div><div><h3>Results</h3><div>During the median 13.7-year follow-up, 1029 (31.9 %) all-cause deaths were observed, including 308 (9.6 %) cardiovascular deaths and 99 (3.1 %) diabetes deaths. Multivariate Cox proportional risk regression models revealed a positive correlation with TyG for all three outcome deaths. A restricted cubic spline demonstrated that the TyG index was linearly and positively associated with diabetes mortality, with U-shaped associations between cardiovascular mortality and all-cause mortality, with thresholds set at 8.87 and 9.37, respectively.</div></div><div><h3>Conclusions</h3><div>Monitoring and maintaining appropriate TyG levels may help reduce the risk of mortality in patients with diabetes and hypertension.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"60 ","pages":"Article 100657"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial global strain supports left atrial end-diastolic volume as a measure of left atrial function","authors":"Sachiyo Igata ,&nbsp;Dwight Bibby ,&nbsp;Qizhi Fang ,&nbsp;Walter Rasmussen ,&nbsp;Theodore Abraham ,&nbsp;Jeffrey Olgin ,&nbsp;Nelson B. Schiller","doi":"10.1016/j.ahjo.2025.100668","DOIUrl":"10.1016/j.ahjo.2025.100668","url":null,"abstract":"<div><h3>Background</h3><div>Left atrial end-diastolic volume index (LAEDVI), the smallest achieved diastolic volume, strongly predicts cardiovascular events. We hypothesize that echocardiographic left atrial reservoir strain (LASr) parallels LAEDVI, providing an additional measurement of LA function.</div></div><div><h3>Methods</h3><div>We analyzed 133 subjects from the BEAT-AFib study. All subjects were in sinus rhythm when studied and were either deemed at risk for atrial fibrillation (Afib) (At-risk, <em>n</em> = 73) or had a history of Afib (Afib, <em>n</em> = 60). The at-risk group had two or more of the following: age &gt; 65 years, hypertension, diabetes, sleep apnea, BMI ≥ 30 kg/m², stable heart failure, and chronic kidney disease without dialysis. We included 83 normal subjects from our laboratory database. LA volumes were measured from 3-dimensional images. LASr was obtained by 2-dimensional speckle tracking R-R gating method from apical 4- and 2- chamber views.</div></div><div><h3>Results</h3><div>LASr was 38 % in normal, 31 % in at-risk, and 23 % in Afib, (<em>p</em> &lt; 0.01). LAEDVI was 11 mL/m² in normal, 15 mL/m² in at-risk, and 21 mL/m² in Afib (<em>p</em> &lt; 0.01). LASr was associated with LAEDVI (<em>r</em> = −0.684), LAESVI (<em>r</em> = −0.528), LA ejection fraction (<em>r</em> = 0.661), E/e’ ratio medial (<em>r</em> = −0.571) (all <em>p</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>LAEDVI are significantly different among normal subjects, those at-risk for Afib development and sinus rhythm with Afib history. LASr paralleled with LAEDVI in its ability to distinguish among these groups indicating that LASr is an additional useful component in evaluating LA function.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"60 ","pages":"Article 100668"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NF-κB and pulmonary hypertension: Advances in mechanistic research and therapeutic applications","authors":"Menghan Si ,&nbsp;Ye Hu ,&nbsp;Zichong Jin ,&nbsp;Yaqi Mao ,&nbsp;Longli Kang","doi":"10.1016/j.ahjo.2025.100669","DOIUrl":"10.1016/j.ahjo.2025.100669","url":null,"abstract":"<div><div>Pulmonary hypertension (PH) is a severe cardiovascular disorder characterized by pulmonary arterial smooth muscle cells (PASMCs) proliferation and vascular remodeling. The nuclear factor-kappa B (NF-κB) family of transcription factors serves as a central mediator of inflammatory responses and plays a critical role in both innate and adaptive immunity. In recent years, the involvement of NF-κB signaling in PH pathogenesis has attracted growing interest. Accumulating evidence indicates that NF-κB contributes to pulmonary vascular remodeling and right ventricular (RV) dysfunction by modulating inflammatory processes, cell proliferation, and apoptosis. This review systematically summarizes the molecular mechanisms by which NF-κB contributes to PH, emphasizing its cell-specific roles in PASMCs and pulmonary arterial endothelial cells (PAECs), and evaluates the therapeutic potential of NF-κB as a target in PH.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"60 ","pages":"Article 100669"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrocardiographic Profiles by sex in a cohort of healthy Vietnamese university students","authors":"Thang Nguyen Ngoc ,&nbsp;Le Nguyen Thi Nhat ,&nbsp;An Pham Van ,&nbsp;Soan Hoang Thu ,&nbsp;Nghia Nguyen Minh ,&nbsp;Thang Vu Tien ,&nbsp;Hong Le Thi Bich ,&nbsp;Hung Tran Viet ,&nbsp;Huyen Pham Thi Thu ,&nbsp;Nhung Do Phuong ,&nbsp;Linh Tran Thi Thuy ,&nbsp;Le Dao Phuong ,&nbsp;Cuong Duong Cao ,&nbsp;Long Nguyen ,&nbsp;Ngoc Nguyen Minh ,&nbsp;Chi Do Thi Kim ,&nbsp;Hien Nguyen Thu ,&nbsp;Huyen Nguyen Thi Thu","doi":"10.1016/j.ahjo.2025.100660","DOIUrl":"10.1016/j.ahjo.2025.100660","url":null,"abstract":"<div><h3>Study objective</h3><div>To establish sex-specific electrocardiographic (ECG) reference values in healthy Vietnamese late adolescents and characterize sex-based differences in repolarization patterns.</div></div><div><h3>Design</h3><div>Cross-sectional observational study.</div></div><div><h3>Setting</h3><div>University health screening program in Vietnam.</div></div><div><h3>Participants</h3><div>A total of 5127 first-year university students (58.6 % female; age 17–29 years), all asymptomatic and without known cardiovascular or metabolic disease.</div></div><div><h3>Interventions</h3><div>None.</div></div><div><h3>Main outcome measures</h3><div>Standard ECG parameters (heart rate, PR interval, QRS duration, QTc, QRST angle), J-point elevation, ST-segment amplitude, and T-wave morphology in leads V1–V6, stratified by sex.</div></div><div><h3>Results</h3><div>Significant sex differences were observed in all ECG parameters (<em>p</em> &lt; 0.001). Females had higher heart rates (83 vs. 80 bpm), shorter PR intervals (138 vs. 140 ms), and longer QTc intervals (423 vs. 406 ms), while males showed longer QRS durations (90 vs. 80 ms) and narrower QRST angles. In precordial leads, males exhibited higher J-point and ST-segment amplitudes, especially in V2–V3, with the 98th percentile of ST60V2 reaching 0.40 mV. Anterior T-wave inversion (TWI) was more common in females, notably in V1 (71.3 % vs. 48.1 %) and V2 (2.5 % vs. 0.9 %). TWI beyond V2 was rare in both sexes.</div></div><div><h3>Conclusion</h3><div>This is the first large-scale study to define sex-specific ECG reference values in a Vietnamese cohort. Marked differences in repolarization patterns emphasize the importance of ethnicity- and sex-specific criteria to enhance diagnostic accuracy and avoid misinterpretation in Southeast Asian populations.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"60 ","pages":"Article 100660"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of diabetes mellitus on one-year outcomes of bioresorbable versus durable polymer drug-eluting stents in patients undergoing percutaneous coronary intervention following rotational atherectomy: Results from a large prospective registry","authors":"Matthew Siano ,&nbsp;Rakhee Makhija ,&nbsp;Neel Patel ,&nbsp;Samantha Sartori ,&nbsp;Serdar Farhan ,&nbsp;David Power ,&nbsp;Yihan Feng ,&nbsp;Wen Chang ,&nbsp;Anton Camaj ,&nbsp;Frank Kalaba ,&nbsp;Vishal Dhulipala ,&nbsp;Keisuke Yasumura ,&nbsp;Roja Thapi ,&nbsp;Pooja Vijay ,&nbsp;Nikito Gurung ,&nbsp;Manish Vinayak ,&nbsp;Amit Hooda ,&nbsp;Parasuram Krishnamoorthy ,&nbsp;Joseph Sweeny ,&nbsp;George Dangas ,&nbsp;Samin Sharma","doi":"10.1016/j.ahjo.2025.100664","DOIUrl":"10.1016/j.ahjo.2025.100664","url":null,"abstract":"<div><h3>Background</h3><div>Patients with diabetes mellitus (DM) have worse outcomes after percutaneous coronary intervention (PCI), even with everolimus-eluting stents (EES). Limited data are available comparing outcomes in DM versus non-DM receiving various bioresorbable polymer (BP) or durable polymer (DP) EES after rotational atherectomy (RA). We aimed to study the impact of DM on outcomes in patients undergoing PCI with BP-EES and DP-EES after RA.</div></div><div><h3>Methods</h3><div>Consecutive patients undergoing PCI with RA between 2014 and 2021 were included. The primary outcome was major adverse cardiac events (MACE), a composite of death, myocardial infarction (MI), or stroke at 1 year, which was stratified according to DM status. Regression analysis was performed to adjust for confounders.</div></div><div><h3>Results</h3><div>Among 2376 patients (mean age 70.3 ± 10.7, 49.5 % DM) that underwent RA, 552 received BP-EES and 1824 received DP-EES. Both groups had similar number of stents implanted and stent diameters; however, the BP-EES group had a higher SYNTAX score and was more likely to have multi-vessel disease and undergo PCI to the left anterior descending, circumflex, and right coronary artery. In both BP-EES and DP-EES groups, there was no significant difference in adjusted risk of MACE (BP-EES: 7.3 % vs. 7.1 %, HR 0.78, 95 % CI 0.35–1.78, <em>P</em> = 0.562 &amp; DP-EES: 7.5 % vs. 3.7 %, HR 1.49, 95 % CI 0.89–2.50, <em>P</em> = 0.130) between diabetics and non-diabetics.</div></div><div><h3>Conclusions</h3><div>Despite differences in baseline characteristics, DM was not associated with worse MACE at one year in patients with complex coronary artery disease undergoing RA and PCI with contemporary BP-EES or DP-EES.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"60 ","pages":"Article 100664"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-cause mortality and cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes and heart failure with reduced ejection fraction","authors":"Aravinthan Vignarajah ,&nbsp;Peter Oro ,&nbsp;Joseph El Dahdah ,&nbsp;Nishanthi Vigneswaramoorthy ,&nbsp;Amanda R. Vest ,&nbsp;Gautam Shah","doi":"10.1016/j.ahjo.2025.100676","DOIUrl":"10.1016/j.ahjo.2025.100676","url":null,"abstract":"<div><h3>Background</h3><div>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a popular first-line treatment option in managing Type 2 Diabetes Mellitus (T2DM) with cardiovascular co morbidities. Studies have established the benefit of GLP-1 RAs in improving cardiovascular (CV) outcomes in patients with T2DM. However, the impact of GLP-1 RAs on mortality and cardiovascular outcomes in patients with T2DM and Heart failure with reduced ejection fraction (HFrEF) remains uncertain.</div></div><div><h3>Methods</h3><div>This retrospective cohort study employed an active-comparator new-user design using the TriNetX Research Network database. Patients aged 18 years or older with T2DM and left ventricular ejection fraction of ≤40 % were identified for inclusion. Patients were classified into two groups: GLP-1 RAs users versus dipeptidyl peptidase 4 inhibitor (DPP4i) users. Propensity score matching (1:1) was conducted based on demographics, body mass index, comorbidities, glycated hemoglobin levels, medications and socioeconomic factors resulting in a matched cohort of 26,196 patients. Outcomes analyzed included all-cause mortality, acute myocardial infarction, cerebrovascular accident, and all-cause hospitalization.</div></div><div><h3>Results</h3><div>The GLP-1 RA user group demonstrated a reduced hazard ratio (HR, 95 % confidence interval) over 5 years compared with the DPP4i user group for all-cause mortality (0.62, 0.59–0.66, <em>P</em> &lt; 0.001), all-cause hospitalization (0.71, 0.69–0.73, <em>P</em> &lt; 0.001), acute myocardial infarction (0.87, 0.82–0.92, <em>P</em> &lt; 0.001), heart failure exacerbation (0.83, 0.81–0.86, <em>P</em> &lt; 0.001) and cerebrovascular accidents (0.85, 0.80–0.92, P &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>In patients with T2DM and HFrEF, GLP-1 RA therapy shows potential beneficial effects in reducing CV events over 5 years compared to control (DPP4i) group.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"60 ","pages":"Article 100676"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiomyopathy in valosin-containing protein multisystem proteinopathy: Evaluation, diagnosis, and management","authors":"Joshua M. Chan ,&nbsp;Candela Romano ,&nbsp;Andy Y. Lee ,&nbsp;Stephani Wang ,&nbsp;Dawn Lombardo ,&nbsp;Forum Kamdar ,&nbsp;Michaela Dora ,&nbsp;Shaida Khan ,&nbsp;Pradeep Mammen ,&nbsp;Virginia Kimonis","doi":"10.1016/j.ahjo.2025.100644","DOIUrl":"10.1016/j.ahjo.2025.100644","url":null,"abstract":"<div><div>Valosin-containing protein (<em>VCP</em>)-associated multisystem proteinopathy is a rare, autosomal dominant disease that affects skeletal muscle, bone, central nervous system, and the heart. While <em>VCP</em> mutations are well established as causing inclusion body myopathy, Paget's disease of bone, frontotemporal dementia, and amyotrophic lateral sclerosis, their role in cardiomyopathy remains underrecognized. This review aims to evaluate the pathophysiology, diagnostic approach, and management of VCP-associated cardiomyopathy to provide a framework for clinical care and future research.</div><div>Emerging evidence from animal models and human case studies suggests that VCP dysfunction disrupts cardiomyocyte homeostasis, impairs protein degradation, and alters mitochondrial function, leading to maladaptive cardiac remodeling and susceptibility to dilated or hypertrophic cardiomyopathy. Echocardiographic studies in patients with VCP variants reveal a significant prevalence of diastolic dysfunction, conduction abnormalities, and variable degrees of systolic impairment. Despite these findings, there are no standardized guidelines for the diagnosis and management of VCP-associated cardiomyopathy. Current treatment strategies are extrapolated from heart failure guidelines, incorporating neurohormonal blockades with angiotensin-converting enzyme inhibitors, beta-blockers, and mineralocorticoid receptor antagonists.</div><div>Our review highlights the need for systematic screening protocols, genotype-phenotype correlation studies, and the development of targeted therapies. Future research should focus on identifying biomarkers for early detection, elucidating the molecular mechanisms underlying cardiac dysfunction, and assessing the efficacy of novel treatment strategies. Recognizing VCP-associated cardiomyopathy as a distinct clinical entity will facilitate earlier diagnosis, improve patient outcomes, pave the way for disease-specific therapeutic interventions and insights into the mechanism for isolated cardiomyopathy.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"60 ","pages":"Article 100644"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term outcomes of acute heart failure hospitalizations in Ethiopia: A multicenter prospective study","authors":"Getachew Yitayew Tarekegn ,&nbsp;Legesse Chekleba ,&nbsp;Tilaye Arega Moges ,&nbsp;Fisseha Nigussie Dagnew ,&nbsp;Samuel Berihun Dagnew ,&nbsp;Sisay Stiotaw Anberbr ,&nbsp;Behailu Terefe Tesfaye","doi":"10.1016/j.ahjo.2025.100665","DOIUrl":"10.1016/j.ahjo.2025.100665","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine the incidence and predictors of unplanned 30-day readmission and in-hospital mortality among adults hospitalized with AHF in Ethiopia.</div></div><div><h3>Methods</h3><div>A multicenter prospective observational study was conducted in six referral hospitals in the Amhara region between December 2023 and April 2024. Adults (≥18 years) with AHF were consecutively enrolled and followed up until discharge and 30 days post-discharge. Kaplan–Meier survival analysis and Cox regression were used to estimate outcomes and predictors.</div></div><div><h3>Results</h3><div>Of the 1131 patients, 275 (24.4 %) were readmitted within 30 days and 121 (10.7 %) died in the hospital. Independent predictors of readmission included hyponatremia (AHR = 10.5; 95 % CI: 3.1–36.2), thrombocytopenia (AHR = 16.7; 95 % CI: 4.8–58.3), ischemic heart disease (AHR = 6.9; 95 % CI: 1.8–27.0), Charlson Comorbidity Index ≥4 (AHR = 6.5; 95 % CI: 1.7–24.6), poor physician adherence to guideline-directed therapy (AHR = 8.2; 95 % CI: 2.3–30.1), and low patient adherence (AHR = 4.8; 95 % CI: 1.6–14.5). Prescription of ACE inhibitors, beta-blockers, and SGLT2 inhibitors at discharge significantly reduced the readmission risk (AHR range: 0.09–0.30). The predictors of in-hospital mortality included reduced ejection fraction, tachycardia, hypoxemia, left bundle branch block, pulmonary hypertension, elevated creatinine, severe hypertension, and pneumonia.</div></div><div><h3>Conclusion</h3><div>AHF patients in Ethiopia experience high short-term readmission and mortality. Correcting electrolyte imbalances, improving comorbidity management, strengthening physician adherence to guideline-directed therapy, and promoting patient adherence are essential for improving outcomes.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"60 ","pages":"Article 100665"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced native T1 on cardiac magnetic resonance imaging as a novel marker of myocardial involvement in Niemann-Pick disease type B","authors":"Betim Redzepi ,&nbsp;Panagiotis Antiochos ,&nbsp;Christel Tran ,&nbsp;Joana Vieira Barbosa ,&nbsp;Ambra Masi ,&nbsp;Meng Zhang ,&nbsp;Revi Adheriyani ,&nbsp;Belinda Campos-Xavier ,&nbsp;Juerg Schwitter","doi":"10.1016/j.ahjo.2025.100636","DOIUrl":"10.1016/j.ahjo.2025.100636","url":null,"abstract":"<div><h3>Background</h3><div>Niemann-Pick disease type B (NPD-B) is a rare lysosomal storage disorder caused by biallelic mutations in the <em>SMPD1</em> gene, leading to deficient acid sphingomyelinase activity and lipid accumulation in various organs. Although cardiac involvement is known in similar disorders like Anderson-Fabry disease, the myocardial impact in NPD-B remains poorly characterized.</div></div><div><h3>Methods</h3><div>Two adult patients with genetically confirmed NPD-B underwent multiparametric cardiac magnetic resonance (CMR) including native T1 mapping and late gadolinium enhancement (LGE). Clinical, biochemical, and histopathological data were reviewed.</div></div><div><h3>Results</h3><div>Patient 1, a 59-year-old man with a homozygous <em>SMPD1</em> mutation (c.[Arg610del]), showed advanced pulmonary disease and liver steatosis. CMR revealed biventricular dilation with preserved systolic function and reduced native T1 values without LGE, suggesting myocardial lipid accumulation. Despite enzyme replacement therapy, the patient died of pulmonary complications 22 months later.</div><div>Patient 2, a 31-year-old woman with compound heterozygous <em>SMPD1</em> mutations (c.[739G &gt; A], c.[1801G &gt; A]), had cirrhosis, dyslipidemia, and stable lung disease. CMR showed normal T1 values and no cardiac abnormalities.</div></div><div><h3>Discussion/conclusions</h3><div>This study compares two adult NPD-B patients who underwent CMR imaging. The first patient who died during follow-up showed reduced native T1 values, suggesting myocardial lipid accumulation, while the second had normal values and no complications during follow-up. These two patients are reported here to stimulate research in this field, as native T1 may aid in assessment of myocardial involvement. The two cases also suggest a potential influence of genetic mutations on disease severity. Given the risk of cardiac involvement in NPD-B, CMR — especially T1 mapping — may be a valuable tool for assessing myocardial infiltration. Future studies are needed to explore its correlation with genotype, disease progression, and treatment response.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"60 ","pages":"Article 100636"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145365066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical treatment of postinfarction thrombosed left ventricle aneurysm formed from coronary artery dissection.","authors":"Olena K. Gogayeva ,&nbsp;Oleksandr O. Nudchenko ,&nbsp;Mykola L. Rudenko ,&nbsp;Anatolii V. Rudenko","doi":"10.1016/j.ahjo.2025.100652","DOIUrl":"10.1016/j.ahjo.2025.100652","url":null,"abstract":"<div><h3>Background</h3><div>Spontaneous coronary artery dissection (SCAD) may lead to acute myocardial infarction (MI), delayed treatment might develop such life-threatening complication as left ventricle aneurysm (LVA) with further embolization due to the presence of a thrombus in the aneurysmal sac.</div></div><div><h3>Material and methods</h3><div>ECG, Echo, coronary angiography and cardiac surgery were performed to a 42-year-old military servant with episodes of dyspnea, dizziness and unconsciousness.</div></div><div><h3>Results</h3><div>There were a signs of postinfarction LVA on ECG. Echo study confirmed LVA with moderate decrease of LV ejection fraction (EF) 35 % and floating thrombus. Coronary angio findings were as following: stenosis of LAD up to 50 %, LCX 60 % with spiral dissection of the LAD. We performed CABG, resection of LVA with thrombectomy on-pump. Patient was discharged on 8th postoperative day. In 15 months after surgery ECHO revealed a recurrent thrombosis of LV apex (LV EF 45 %) that is characterized by increased mobility and heterogeneous structure. Ultrasound exam of lower extremities arteries revealed two thrombotic occlusions: one of the right posterior tibial artery in the middle segment, and another of the left anterior tibial artery in the distal segment. Reoperation was performed on-pump (13 min fibrillation and 98 min perfusion time). Patient was discharged on 6th day after surgery.</div></div><div><h3>Conclusion</h3><div>Our clinical case demonstrates successful surgical treatment of patient with thrombosed LVA, which appeared after MI due to the coronary artery dissection. Uncontrolled anticoagulation therapy was one of the reasons for recurrent LV thrombosis with low extremities arteries embolization which required on-pump redo cardiac surgery.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"60 ","pages":"Article 100652"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145365218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}