American heart journal plus : cardiology research and practice最新文献

{"title":"The design and rationale of the cardiac REHABilitation to improve metabolic health in Hypertrophic CardioMyopathy (REHAB-HCM) Study.","authors":"Matthew Cheung, Nathaniel Moulson, Jinelle C Gelinas, Ali Daraei, Sarah M Bradwell, Carolyn Taylor, Neil D Eves, Graeme J Koelwyn, Thomas M Roston","doi":"10.1016/j.ahjo.2025.100501","DOIUrl":"https://doi.org/10.1016/j.ahjo.2025.100501","url":null,"abstract":"<p><strong>Study objective: </strong>Hypertrophic cardiomyopathy (HCM) is the most common genetic myocardial disorder increasingly characterized by concomitant metabolic syndrome. Cardiac rehabilitation (CR) has been shown to improve metabolic parameters in populations with heart failure and myocardial infarction. However, there is a paucity of data on the impact of CR in the HCM population with metabolic syndrome. We designed the REHAB-HCM study to explore the feasibility, safety, and efficacy of CR in HCM patients with metabolic syndrome.</p><p><strong>Design: </strong>Prospective observation cohort study.</p><p><strong>Setting: </strong>A multi-disciplinary HCM clinic and Multidisciplinary Exercise-based Cardiac Rehabilitation program.</p><p><strong>Participants: </strong>Patients aged 18-80 years old diagnosed with HCM and metabolic syndrome, defined by the American Heart Association and American College of Cardiology guidelines, and the National Cholesterol Education Adult Treatment Panel III (NCEP-ATP III) criteria.</p><p><strong>Intervention: </strong>A structured 3-month CR program with 6 months extended follow-up of physical activity levels.</p><p><strong>Main outcome measures: </strong>Feasibility (e.g., attendance), safety (e.g., major adverse events and exercise-related harms), and efficacy pertaining to long term improvements in physical activity levels, metabolic health, cardiorespiratory fitness, quality of life, and systemic and cellular markers of inflammation.</p><p><strong>Conclusion: </strong>This prospective cohort study will address an important knowledge gap by evaluating the effect of an organized CR program in HCM patients and metabolic syndrome. It is anticipated that exercise and CR will be feasible and beneficial for this complex patient population without significant exercise-related harms.</p>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"50 ","pages":"100501"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underlying and contributing causes of mortality from CDC WONDER-Insights for researchers.","authors":"Abdul Mannan Khan Minhas, Laurence S Sperling, Sadeer Al-Kindi, Dmitry Abramov","doi":"10.1016/j.ahjo.2025.100499","DOIUrl":"https://doi.org/10.1016/j.ahjo.2025.100499","url":null,"abstract":"<p><strong>Background: </strong>The multiple cause of death files available through the Center for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) present underlying and contributing causes of mortality. We sought to evaluate potential differences in mortality reporting that may occur based on utilization of only underlying versus utilization of both underlying and contributing cause of mortality.</p><p><strong>Methods: </strong>All-cause and top 5 underlying causes of deaths in individuals ≥25 years of age from 2011 to 2019 occurring within United States were extracted from CDC WONDER. Deaths for the top 5 underlying causes of death as underlying and as underlying or contributing causes were extracted. For each cause, we calculated the percentage of the deaths that would be reported if only the underlying versus the underlying or contributing mortality was reported.</p><p><strong>Results: </strong>Between 2011 and 2019, the top 5 underlying causes of mortality were heart disease, malignant neoplasm, chronic lower respiratory disease, cerebrovascular disease, and accidents. For these causes, the percentages of deaths presented by reporting (underlying)/(underlying or contributing) causes were 53 %, 91 %, 50 %, 59 %, and 79 % respectively.</p><p><strong>Discussion/conclusion: </strong>Data within the commonly utilized multiple cause of death files from CDC WONDER demonstrate that reliance solely on the underlying cause of mortality may underestimate important contributions of common contributing causes. These findings could aid in the understanding of published research and may shape the framework for future studies utilizing multiple cause of death data through CDC WONDER.</p>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"50 ","pages":"100499"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and race disparities in emergency department patients with chest pain and a detectable or mildly elevated troponin.","authors":"Lucas M Boyer, Anna C Snavely, Jason P Stopyra, Subha V Raman, Jeffrey M Caterino, Carol L Clark, Alan E Jones, Michael E Hall, Carolyn J Park, Brian C Hiestand, Sujethra Vasu, Michael A Kutcher, W Gregory Hundley, Simon A Mahler, Chadwick D Miller","doi":"10.1016/j.ahjo.2024.100495","DOIUrl":"10.1016/j.ahjo.2024.100495","url":null,"abstract":"<p><strong>Background: </strong>Identifying and eliminating health disparities is a public health priority. The goal of this analysis is to determine whether cardiac testing or outcome disparities exist by race or sex in patients with detectable to mildly elevated serum troponin.</p><p><strong>Methods: </strong>We conducted a secondary analysis of the CMR-IMPACT trial that randomized patients with symptoms suggestive of acute coronary syndrome and a detectable or mildly elevated troponin measure from 4 US hospitals to an early invasive angiography or cardiac MRI strategy. The primary endpoint was the composite of all-cause mortality, myocardial infarction, cardiac hospital readmission, and repeat cardiac ED. Secondary outcomes were components of the composite and revascularization.</p><p><strong>Results: </strong>Participants (<i>n</i> = 312, mean age 61 ± 11 years) were 36.2 % non-white and 40.1 % female. The composite outcome occurred in 63.7 % of non-white vs. 49.8 % of white patients (aHR 1.50, 95 % CI 1.08-2.09) and 53.6 % of female vs. 55.6 % of male patients (aHR 0.93, 95 % CI 0.68-1.28). Non-white (aHR 0.57, 95 % CI 0.35-0.92) patients had lower rates of revascularization also less median stenosis (<i>p</i> < 0.001) and stenosis >70 % (p < 0.001) during index cardiac testing. Despite these findings, ACS after discharge was higher among non-white patients (aHR 1.84, 95 % CI 1.11-3.05). Females had lower rates of revascularization (aHR 0.52, 95 % CI 0.33-0.82), but no increase in ACS after discharge (aHR 0.90, 95 % CI 0.55-1.49).</p><p><strong>Conclusion: </strong>Non-white patients had higher rates of ACS following discharge despite lower rates of obstructive CAD following standardization of index cardiac testing. Future disparity works should explore care following the index encounter.</p>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"49 ","pages":"100495"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cathepsin-D and outcomes in peripartum cardiomyopathy: Results from IPAC.","authors":"Vincenzo B Polsinelli, Karen Hanley-Yanez, Charles F McTiernan, Kalgi Modi, Jennifer Haythe, Hal Skopicki, Uri Elkayam, Leslie T Cooper, James D Fett, Dennis M McNamara","doi":"10.1016/j.ahjo.2024.100489","DOIUrl":"10.1016/j.ahjo.2024.100489","url":null,"abstract":"<p><strong>Objective: </strong>Evaluate the relationship of cathepsin-D (CD) on disease severity and clinical outcomes for women with peripartum cardiomyopathy.</p><p><strong>Background: </strong>Cathepsin-D is a protease released during oxidative stress that cleaves prolactin (PRL) generating a 16 kDa fragment that is pro-apoptotic, anti-angiogenic, and has been implicated in the pathogenesis of peripartum cardiomyopathy (PPCM).</p><p><strong>Methods: </strong>In 99 women with newly diagnosed PPCM enrolled in the Investigation in Pregnancy Associated Cardiomyopathy (IPAC) study, CD levels were assessed by ELISA from serum obtained at study entry. Left ventricular ejection fraction (LVEF) was assessed by echocardiography at entry, 6, and 12-months. CD levels were compared to healthy PP and non-PP controls. Survival free from major cardiovascular events (death, transplantation, or left ventricular assist device) was determined up to 12 months post-partum (PP).</p><p><strong>Results: </strong>Mean age was 30 ± 6 years, with a baseline LVEF of 34 % ± 10. Cathepsin-D levels were higher in PPCM women (278 ± 114 ng/ml) than in healthy PP (190 ± 74, <i>p</i> = 0.02) and healthy non-PP controls (136 ± 79, <i>p</i> < 0.001). There was no association of CD with age, breastfeeding status, or time from delivery to the presentation. Cathepsin-D levels were higher in women with higher New York Heart Association (NYHA) functional class (<i>p</i> = 0.001). Higher tertiles of CD levels were associated with lower event-free survival (<i>p</i> = 0.008).</p><p><strong>Conclusions: </strong>In this prospective cohort of women with PPCM, higher CD levels at the time of diagnosis were associated with worse symptoms, less recovery of LVEF, and worse clinical outcomes. Circulating CD may contribute to the development of PPCM and influence disease severity, myocardial recovery, and clinical outcomes.</p>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"49 ","pages":"100489"},"PeriodicalIF":1.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging the postpartum period to reduce racial disparities in postpartum hypertension care.","authors":"Malamo E Countouris, Jared W Magnani","doi":"10.1016/j.ahjo.2024.100490","DOIUrl":"https://doi.org/10.1016/j.ahjo.2024.100490","url":null,"abstract":"<p><p>Pregnancy provides a window of opportunity for management of hypertension care. Particularly in the postpartum period - the so-called \"4th trimester\" - individuals of Black race are at increased risk for hypertension-related morbidity and mortality. Telehealth interventions, such as remote blood pressure monitoring programs and virtual postpartum visits, can reduce racial disparities in the delivery of recommended care. System and policy changes can address social factors that impact postpartum care as well. Cardiovascular clinicians have a key role to play in managing hypertension and addressing cardiovascular disease prevention strategies during reproductive years.</p>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"49 ","pages":"100490"},"PeriodicalIF":1.3,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in stroke-related mortality in atrial fibrillation patients in the United States: Insights from the CDC WONDER database.","authors":"Muhammad Abdullah Naveed, Sivaram Neppala, Himaja Dutt Chigurupati, Muhammad Omer Rehan, Ahila Ali, Hamza Naveed, Bazil Azeem, Rabia Iqbal, Manahil Mubeen, Mashood Ahmed, Ayman R Fath, Timir Paul, Bilal Munir","doi":"10.1016/j.ahjo.2024.100491","DOIUrl":"https://doi.org/10.1016/j.ahjo.2024.100491","url":null,"abstract":"<p><strong>Background: </strong>Stroke associated with atrial fibrillation (AF) is a significant cause of mortality. This study analyzed demographic trends and disparities in mortality rates due to stroke in AF patients aged ≥25 years.</p><p><strong>Methods: </strong>A retrospective analysis was conducted to acquire death data using the Centers for Disease Control and Prevention database from 1999 to 2020. Age-adjusted mortality rates (AAMRs) were calculated per 100,000 persons, and trends were assessed using Average Annual Percentage Change (AAPC) and annual percent change (APC). Data were stratified by year, sex, race/ethnicity, and geographical regions.</p><p><strong>Results: </strong>Between 1999 and 2020, AF-associated stroke contributed to 331,106 deaths among adults in this study population. Deaths occurred predominantly in medical facilities (43.2 %). The overall AAMR for AF-associated stroke decreased from 7.4 in 1999 to 6.4 in 2020, with an APC of -1.02 (<i>p</i>-value = 0.004). Additionally, AAMR showed a significant decline from 2015 to 2018 with an APC of -7.22 (p-value <0.000001), followed by a striking rise from 2018 to 2020 (APC: 4.98) (p-value = 0.0008). Women had slightly higher AAMR than men (men: 6.6; women: 7.1) (<i>p</i> value = 0.02). AAMRs varied among racial/ethnic groups, with Whites having the highest AAMR (7.4), followed by Blacks (5.4), American Indian or Alaska Natives (4.6), Asian or Pacific Islanders (4.5), and Hispanics (4.1). AAMRs decreased for all races except Blacks. Geographically, AAMRs ranged from 4.3 in Nevada to 11.9 in Vermont, with the Western region showing the highest mortality (AAMR: 7.9). Nonmetropolitan areas had slightly higher AAMRs than metropolitan areas, with both experiencing a decrease over the study period.</p><p><strong>Conclusion: </strong>This analysis depicts significant demographic and geographic disparities in mortality rates attributed to stroke associated with AF. Targeted interventions and equitable healthcare access are crucial to mitigate these disparities and improve outcomes for this population.</p>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"49 ","pages":"100491"},"PeriodicalIF":1.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing predictive risk to actual presence of coronary atherosclerosis on coronary computed tomography angiography.","authors":"Emma Playford, Simon Stewart, Gerard Hoyne, Geoff Strange, Girish Dwivedi, Christian Hamilton-Craig, Gemma Figtree, David Playford","doi":"10.1016/j.ahjo.2024.100493","DOIUrl":"https://doi.org/10.1016/j.ahjo.2024.100493","url":null,"abstract":"<p><strong>Background: </strong>There is limited data showing the predictive accuracy of traditional cardiovascular risk scores (CVRS) to predict asymptomatic coronary artery disease (CAD) determined by coronary computed tomography angiography (CCTA).</p><p><strong>Methods: </strong>Asymptomatic individuals without known CAD undergoing a screening CCTA and sufficient data to calculate their CVRS, were extracted retrospectively. Atherosclerosis was extracted using natural language processing of the CCTA report, including the coronary artery calcium score (CACS) and the extent and severity of CAD. Absence of atherosclerosis was defined as both zero plaque and zero CACS, and atherosclerosis was defined as low, moderate, or extensive by location and extent of plaque-burden. CVRS was categorized as high (>15 %), moderate (10-15 %), low (1-9 %) and \"zero\" (<1 %) risk.</p><p><strong>Results: </strong>828 individuals (median age 58.6, IQR = 52.0, 65.3 years, 57 % male) met inclusion criteria, and a zero, low, moderate, and high CVRS was identified in 13, 483, 113 and 219 individuals (8 %, 49 %, 74 %, 66 % male), respectively. Predominantly low plaque-burden atherosclerosis was detected in 548 scans (67 % male). However, of the 137 males and 68 females with extensive atherosclerosis, 47 (34 %) and 38 (56 %) respectively had low CVRS classification. Overall, 23 % of males and 31 % of females had CAD predicted by CVRS (Monte Carlo: females, <i>p</i> = 0.024; males, <i>p</i> < 0.001), but there was little to no agreement between CVRS and atherosclerosis burden (Cohen's kappa: males, <i>κ</i> = 0.149; females, <i>κ</i> = 0.096).</p><p><strong>Conclusions: </strong>In asymptomatic individuals without known CAD, a low CVRS does not exclude extensive CAD. Newer tools incorporating additional markers may be helpful in risk prediction in such individuals.</p>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"49 ","pages":"100493"},"PeriodicalIF":1.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical recommendations for telehealth and electronic consultations in the veterans health administration referral coordination initiative.","authors":"David E Winchester, Lisa Arfons","doi":"10.1016/j.ahjo.2024.100492","DOIUrl":"https://doi.org/10.1016/j.ahjo.2024.100492","url":null,"abstract":"<p><p>Telemedicine Veterans health services Cardiology Referral Consultation.</p>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"49 ","pages":"100492"},"PeriodicalIF":1.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The uses of right heart catheterization in cardio-pulmonary disease: State-of-the-art.","authors":"Bhavesh Katbamna, Lingling Wu, Mario Rodriguez, Phillip King, Joel Schilling, Jamal Mahar, Ajith P Nair, Hani Jneid, Elizabeth S Klings, Gerald L Weinhouse, Sula Mazimba, Marc A Simon, Markus Strauss, Chayakrit Krittanawong","doi":"10.1016/j.ahjo.2024.100488","DOIUrl":"https://doi.org/10.1016/j.ahjo.2024.100488","url":null,"abstract":"<p><p>The right heart catheterization (RHC) remains an important diagnostic tool for a spectrum of cardiovascular disease processes including pulmonary hypertension (PH), shock, valvular heart disease, and unexplained dyspnea. While it gained widespread utilization after its introduction, the role of the RHC has evolved to provide valuable information for the management of advanced therapies in heart failure (HF) and cardiogenic shock (CS) to name a few. In this review, we provide a comprehensive overview on the indications, utilization, complications, interpretation, and calculations associated with RHC.</p>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"49 ","pages":"100488"},"PeriodicalIF":1.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a nomogram that predicts the risk of heart failure in hemodialysis patients.","authors":"Jie Luo, Zhangru Rui, Yun He, Hui Li, Yang Yuan, Wenhong Li","doi":"10.1016/j.ahjo.2024.100487","DOIUrl":"https://doi.org/10.1016/j.ahjo.2024.100487","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is expected to become the fifth leading cause of death globally by 2040. Cardiovascular disease (CVD), particularly heart failure (HF), is a severe complication in CKD patients on hemodialysis. This study aimed to develop a nomogram to predict the risk of heart failure hospitalization in hemodialysis patients, providing a valuable tool for clinical decision-making. We retrospectively analyzed data from 196 patients at Kunming Yanan Hospital's hemodialysis center, including demographic, dialysis-related, and laboratory information. Significant HF predictors identified through univariate and multivariate logistic regression were age, diabetes, dialysis duration, left ventricular mass index (LVMI), albumin (ALB), and ejection fraction (EF). These predictors formed the basis of the nomogram, which demonstrated good discrimination (AUC = 0.728) and calibration (Hosmer-Lemeshow test, <i>P</i> = 0.463). Decision curve analysis confirmed the nomogram's clinical utility across various threshold probabilities. This study's findings can help clinicians identify high-risk patients, improving management strategies and potentially reducing HF-related hospitalizations in the hemodialysis population.</p>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"49 ","pages":"100487"},"PeriodicalIF":1.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}