American heart journal plus : cardiology research and practice最新文献

{"title":"Understanding veteran perspectives surrounding implantable cardioverter- defibrillator decision-making","authors":"Gretchen C. Stage,&nbsp;Marcie Lee,&nbsp;Jazmin I. Beltran,&nbsp;Krysttel C. Stryczek,&nbsp;Daniel D. Matlock,&nbsp;Laura Scherer,&nbsp;Christopher E. Knoepke,&nbsp;Wanda L. Bernstein,&nbsp;Paul D. Varosy,&nbsp;Amneet Sandhu","doi":"10.1016/j.ahjo.2026.100953","DOIUrl":"10.1016/j.ahjo.2026.100953","url":null,"abstract":"<div><h3>Background</h3><div>In 2018, the Center for Medicare and Medicaid Services (CMS) mandated the use of evidence-based shared decision-making (SDM) tools for cardiovascular decisions, including implantable cardioverter defibrillator (ICD) implantation for primary prevention in patients with systolic heart failure. Military Veterans are a unique population with experiences including combat, and heightened rates of anxiety, depression and post-traumatic stress disorder. Understanding Veteran perspectives on ICD decision-making processes is necessary to inform the Veteran Health Administration's (VHA) ICD care model.</div></div><div><h3>Study objective</h3><div>To understand factors influencing Veterans' ICD decision-making, semi-structured interviews were conducted with Veteran patients with an ICD (Implanters), those referred for consideration (Deliberators), and those who declined (Decliners).</div></div><div><h3>Methods</h3><div>Interviews explored experiences with being offered an ICD, understanding of the device, and factors influencing personal decisions. Data were analyzed using content and thematic analysis.</div></div><div><h3>Results</h3><div>Interviews with 13 participants revealed four primary themes that guided ICD decision-making: (1) desire for information and involvement in personal decisions, (2) quality of life values, (3) views of spirituality (4) Decliners and Deliberators accepted natural death and expressed desire to not intervene medically to prolong life.</div><div>Participants valued consultation with providers and personal networks, yet ultimately prioritized autonomy. The role of mental health experiences and cohort-level differences on decision-making was inconclusive.</div></div><div><h3>Conclusion</h3><div>Participants' ICD implantation decision-making were influenced by considerations around quality of life, spiritual beliefs, and reluctance to invasively interfere with disease progression. These insights highlight the importance of personalized patient-provider interactions and the need for decision-support tools tailored to VHA Veteran care.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"71 ","pages":"Article 100953"},"PeriodicalIF":2.3,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Mechanisms of gut microbiota metabolite-mediated gut-heart Axis in heart failure: An integrative study based on network pharmacology”","authors":"Shaik Shafiya Begum,&nbsp;Mohammad Mansoor,&nbsp;Ranakishor Pelluri","doi":"10.1016/j.ahjo.2026.100946","DOIUrl":"10.1016/j.ahjo.2026.100946","url":null,"abstract":"","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"71 ","pages":"Article 100946"},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149144752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of monocyte-to-HDL and neutrophil-to-HDL cholesterol ratio for obstructive coronary artery disease in Patients undergoing coronary angiography","authors":"Dania A. Bani Hani,&nbsp;Jafar A. Alshraideh,&nbsp;Afaf S. Yousef,&nbsp;Abeer A. Alwahadneh,&nbsp;Meshal Matar Alenazi,&nbsp;Ja'’far M. Alkhawaldeh,&nbsp;Hamza Alduraidi,&nbsp;Shaker Al-Nabulsi,&nbsp;Salah S. Al-Zaiti","doi":"10.1016/j.ahjo.2026.100943","DOIUrl":"10.1016/j.ahjo.2026.100943","url":null,"abstract":"<div><h3>Background</h3><div>The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) are emerging composite biomarkers that reflect systemic inflammatory status and lipid metabolism. Although both indices have individually been associated with coronary artery disease (CAD), evidence directly comparing their diagnostic performance for obstructive CAD remains scarce.</div></div><div><h3>Objective</h3><div>This study aims to compare the diagnostic performance of MHR and NHR in identifying obstructive CAD among patients undergoing elective coronary angiography.</div></div><div><h3>Methods</h3><div>A prospective cohort study was conducted involving patients who underwent diagnostic coronary angiography in Jordan. Obstructive CAD was defined as stenosis of 50% or more in a major epicardial vessel on invasive coronary angiography.</div></div><div><h3>Results</h3><div>A total of 215 patients were included, of whom 129 (60%) were male, with a mean age of 58.4 ± 11.4 years; 43.7% had obstructive CAD. After adjusting for age, sex, and prior CAD history in multivariate regression analysis, MHR remained an independent predictor of obstructive CAD (OR = 1.99, 95% CI: 1.34–2.97, <em>p</em> &lt; 0.001), whereas NHR was not independently associated (OR = 1.66, 95%CI: 0.74–3.69, <em>p</em> = 0.21). The clinical model integrating MHR demonstrated an AUC of 0.801 (95% CI: 0.74–0.86); however, this numerical increase was not statistically significant (DeLong test, <em>p</em> = 0.216).</div></div><div><h3>Conclusion</h3><div>MHR may have potential value for risk stratification in obstructive CAD. Although adding MHR to the clinical model resulted in a numerically higher AUC, the incremental improvement in discrimination was not statistically significant. Further studies involving larger, multicenter cohorts are needed to establish the incremental predictive and clinical utility of MHR.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"71 ","pages":"Article 100943"},"PeriodicalIF":2.3,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149144684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous left atrial appendage occlusion versus oral anticoagulation in atrial fibrillation: A pragmatic meta-analysis of randomized trials within the DOAC era","authors":"Gabriel Moraes Kuniyoshi,&nbsp;Rafael Zoppi Campane,&nbsp;Nikita Patil,&nbsp;Ana Clara Vitorino de Oliveira,&nbsp;Beatriz Araújo,&nbsp;Ricardo Ryoshim Kuniyoshi","doi":"10.1016/j.ahjo.2026.100942","DOIUrl":"10.1016/j.ahjo.2026.100942","url":null,"abstract":"<div><h3>Background</h3><div>Percutaneous left atrial appendage occlusion (LAAO) is an established alternative to oral anticoagulation (OAC). However, its safety and efficacy boundaries remain incompletely defined in dedicated comparisons against direct oral anticoagulants (DOACs).</div></div><div><h3>Objective</h3><div>This study applied a pragmatic framework to evaluate the comparative efficacy and safety of LAAO versus OAC in a DOAC-predominant setting.</div></div><div><h3>Methods</h3><div>PubMed, Embase, and Cochrane Library were searched for randomized controlled trials comparing LAAO with OAC, restricted to a DOAC-predominant comparator. Risk ratios (RR) with 95% confidence intervals (CI) were calculated via a Mantel-Haenszel random-effects model.</div></div><div><h3>Results</h3><div>Four trials comprising 5890 patients were included (96.4% of controls assigned to DOACs). Overall stroke (RR 1.18, 95% CI 0.87–1.60; <em>p</em> <em>=</em> 0.28), systemic embolism (RR 1.09, 95% CI 0.29–4.08; <em>p</em> = 0.89), major bleeding (RR 0.98, 95% CI 0.81–1.19; <em>p</em> = 0.84), hemorrhagic stroke (RR 0.82, 95% CI 0.45–1.51; <em>p</em> = 0.53), and all-cause mortality (RR 1.00, 95% CI 0.85–1.17; <em>p</em> = 0.98) did not differ significantly. Ischemic stroke presented numerical asymmetry favoring OAC that approached statistical significance (RR 1.36, 95% CI 0.99–1.89; <em>p</em> = 0.06). Conversely, within available protocol-defined datasets, LAAO significantly reduced nonprocedural clinically relevant bleeding (RR 0.50, 95% CI 0.43–0.60; <em>p</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>In a pragmatic analysis of the DOAC era, randomized data show no statistically significant differences for hard individual endpoints, though broad confidence intervals reflect precision limits. A numerical asymmetry for ischemic stroke favored OAC, while LAAO reduced nonprocedural clinically relevant bleeding. Current evidence remains non-definitive, warranting shared clinical decision-making to balance individual thromboembolic risks against long-term bleeding susceptibility.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"71 ","pages":"Article 100942"},"PeriodicalIF":2.3,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149144765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Multicenter, randomized controlled study evaluating percutaneous and non-fluoroscopic procedure of atrial septal defects—study protocol of the PANASD randomized controlled trial” [Am. Heart J. Plus: Cardiol. Res. Pract. 64 (2026) 100747]","authors":"Junke Chang,&nbsp;Jing Dong,&nbsp;Fengwen Zhang,&nbsp;Cheng Wang,&nbsp;Wenbin Ouyang,&nbsp;Fang Fang,&nbsp;Chuangshi Wang,&nbsp;Xiangbin Pan","doi":"10.1016/j.ahjo.2026.100851","DOIUrl":"10.1016/j.ahjo.2026.100851","url":null,"abstract":"","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"70 ","pages":"Article 100851"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for the Special Issue on Cholesterol Crystal Embolization","authors":"George S. Abela","doi":"10.1016/j.ahjo.2026.100895","DOIUrl":"10.1016/j.ahjo.2026.100895","url":null,"abstract":"","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"70 ","pages":"Article 100895"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An urgent call for quality measures for cardiac implantable electronic device infections in the United States","authors":"Sami El-Dalati,&nbsp;Luke Strnad,&nbsp;Evan Shalen,&nbsp;Oliver Monfredi,&nbsp;Shinichi Fukuhara,&nbsp;Karl Ilg,&nbsp;Sean Pokorney,&nbsp;John Gurley,&nbsp;Charles Love","doi":"10.1016/j.ahjo.2026.100867","DOIUrl":"10.1016/j.ahjo.2026.100867","url":null,"abstract":"<div><div>Infection is a significant cause of morbidity and mortality among patients with cardiac implantable electronic devices (CIEDs). Over 400,000 CIEDs are placed annually in the United States with an infection rate of approximately 1-2% in the first 12 months after implantation. In 2010, the American Heart Association provided a class I recommendation for complete system removal in all cases of endovascular CIED-I or pocket infection. Retrospective studies have shown that CIED removal is associated with improved outcomes, and prompt CIED removal within 7 days of confirmed infection is associated with lower mortality at 1-year compared to extraction after 7 days. Despite these strong recommendations and existing evidence, data demonstrates that ∼80% of patients with CIED-I do not undergo device extraction. To address this gap, we advocate for creation of an electronic clinical quality measure (eCQM) that would create incentives for hospitals to provide efficient, guideline-concordant care, analogous to existing eCQMs for other conditions, such as ST elevation myocardial infarctions. At present, patients with CIED-Is are dying unnecessarily due to non-adherence with evidence-based, guideline recommended care. Healthcare providers and professional societies, working alongside government agencies, have an opportunity to significantly improve outcomes by developing a sustainable, accountable care model for CIED-Is.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"70 ","pages":"Article 100867"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and lactation as window to maternal cardiovascular health","authors":"Corinne E. Chatham,&nbsp;Egle Bytautiene Prewit,&nbsp;Daniela Crousillat,&nbsp;Alex M. Parker,&nbsp;Adetola F. Louis-Jacques","doi":"10.1016/j.ahjo.2026.100790","DOIUrl":"10.1016/j.ahjo.2026.100790","url":null,"abstract":"","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"66 ","pages":"Article 100790"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetocardiography comes of age: From biophysical signal to clinical decision-making","authors":"Robert Takla ,&nbsp;Mazen Awais","doi":"10.1016/j.ahjo.2026.100765","DOIUrl":"10.1016/j.ahjo.2026.100765","url":null,"abstract":"","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"65 ","pages":"Article 100765"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147803494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Cannabis use and Survival in patients with heart failure: A claims-based cohort study of commercially insured adults","authors":"Onyedika J. Ilonze ,&nbsp;Xiaochun Li ,&nbsp;Fangqian Ouyang ,&nbsp;Larry A. Allen ,&nbsp;Robert L. Page ,&nbsp;Sara K. Quinney ,&nbsp;Denise Christina Vidot ,&nbsp;Sarah Chuzi ,&nbsp;Khadijah Breathett","doi":"10.1016/j.ahjo.2026.100766","DOIUrl":"10.1016/j.ahjo.2026.100766","url":null,"abstract":"<div><div>We aimed to examine the prevalence of documented cannabis use and its association with survival among patients with HF using the Optum Clinoformatics dataset, large, national informatics dataset. We demonstrated low period prevalence of cannabis use among patients with heart failure and there was no statistically significant difference (<em>p</em> = 0.76) in all-cause mortality between individuals who use cannabis versus non-users.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"64 ","pages":"Article 100766"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147599938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}