American heart journal plus : cardiology research and practice最新文献

{"title":"Direct oral anticoagulants versus low-molecular-weight heparin for thromboprophylaxis in cancer-related surgeries: A meta-analysis of efficacy and safety outcomes","authors":"Asma Mousavi ,&nbsp;Shayan Shojaei ,&nbsp;Parham Dastjerdi ,&nbsp;Soheil Rahmati ,&nbsp;Kasra Izadpanahi ,&nbsp;Homayoun Pishraft-sabet ,&nbsp;Elmira Jafari Afshar ,&nbsp;Keyvan Salehi ,&nbsp;Mahshad Sabri ,&nbsp;Mahsa Noohi Arbatan ,&nbsp;Parisa Fallahtafti ,&nbsp;Aronow Wilbert ,&nbsp;Andrew P. Ambrosy ,&nbsp;Mushabbar A. Syed ,&nbsp;Mina Iskander ,&nbsp;Kaveh Hosseini","doi":"10.1016/j.ahjo.2025.100607","DOIUrl":"10.1016/j.ahjo.2025.100607","url":null,"abstract":"<div><h3>Background</h3><div>Post-operative venous thromboembolism (VTE) remains a concern following cancer-related surgeries. This systematic review and meta-analysis aimed to evaluate the safety and efficacy of direct oral anticoagulants (DOACs) compared to low molecular weight heparin (LMWH) for thromboprophylaxis after cancer-related surgeries.</div></div><div><h3>Methods</h3><div>We systematically searched databases for studies comparing DOACs to LMWH for post-operative thromboprophylaxis in patients undergoing cancer-related surgeries. Primary outcomes were VTE incidence and bleeding events. Secondary outcomes included all-cause mortality and hospitalization rates. Subgroup analyses examined DOAC type, cancer type, and follow-up duration. A random-effects model calculated pooled risk ratios (RRs) with 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>Analysis included 16 studies with 6400 participants in the DOAC group (mean age 62.05 years, 28.15 % male) and 5801 participants in the LMWH group (mean age 60.78 years, 34.65 % male). DOACs were non-inferior to LMWH for VTE prevention (RR = 0.81, 95 % CI 0.56 to 1.16) with no significant difference in bleeding rates (RR = 0.70, 95 % CI 0.70 to 1.18). Mortality and hospitalization rates were similar between groups. Subgroup analyses suggested possible VTE reduction with DOACs in urological cancer surgeries (RR = 0.52, 95 % CI 0.44 to 0.61) and lower bleeding trends with Apixaban (RR = 0.64, 95 % CI 0.44 to 0.94).</div></div><div><h3>Conclusions</h3><div>DOACs appear non-inferior to LMWH for post-operative thromboprophylaxis in patients undergoing cancer-related surgeries, with comparable safety. The superior VTE prevention in urological cancer surgeries and Apixaban's favorable safety profile warrant further investigation. Moreover, additional research is necessary to clarify the roles of specific DOACs and optimal prophylaxis strategies across various cancer types and surgical procedures.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100607"},"PeriodicalIF":1.8,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous retrieval of a fractured coronary catheter: A case report","authors":"Chengli Tao ,&nbsp;Aixia Zhou ,&nbsp;Shuang Wu ,&nbsp;Xiaohui Chang","doi":"10.1016/j.ahjo.2025.100608","DOIUrl":"10.1016/j.ahjo.2025.100608","url":null,"abstract":"<div><h3>Background</h3><div>Intravascular angiographic catheter fracture is an extremely rare but critical complication of percutaneous coronary intervention (PCI). Conventional retrieval strategies (e.g., surgical intervention, snares) may prolong procedures and raise peri-procedural complication risks. Herein, we report a case of successful retrieval of a fractured catheter using an innovative technique.</div></div><div><h3>Case presentation</h3><div>A 59-year-old female with 7-year hypertension was admitted for 3-month recurrent exertional angina. Right radial coronary angiography was performed, during which a TIG catheter fractured ∼8 cm proximal to the ulnar-radial bifurcation in the right brachial artery. Initial attempts to retrieve it via a Runthrough NS guidewire failed.</div><div>To retrieve the fragment, we sequentially advanced JR3.5, 6FBL3.0, and 6FJR3.5 guiding catheters via the right radial arterial sheath to the proximal stump, then tried advancing a Cross-IT XTR guidewire along them—this maneuver remained unsuccessful.</div><div>Subsequently, an inferior vena cava (IVC) filter retriever via the right radial sheath failed to snare the proximal stump. We then constructed a custom snare by looping a Runthrough NS guidewire at an extension catheter tip, and retrieved the fragment via balloon-assisted counter-traction.</div><div>Postoperatively, the patient was stable without complications. Dual antiplatelet therapy and follow-up were initiated, with no adverse events at 1-month follow-up.</div></div><div><h3>Conclusion</h3><div>This minimally invasive technique obviates surgery, shows promise for intravascular foreign body management, and provides insights for adapting to failed conventional strategies in complex cases.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100608"},"PeriodicalIF":1.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of coronary artery disease involvement in patients with or without familial history","authors":"Ramin Khameneh Bagheri ,&nbsp;Hosna Hosseini Moghaddam ,&nbsp;Mostafa Ahmadi ,&nbsp;Ali Eshraghi ,&nbsp;Maryam Emadzadeh ,&nbsp;Faeze Keihanian ,&nbsp;Aida Yavari Kondori","doi":"10.1016/j.ahjo.2025.100609","DOIUrl":"10.1016/j.ahjo.2025.100609","url":null,"abstract":"<div><h3>Introduction</h3><div>Family history (FH) and genetic factors contribute significantly to coronary artery disease (CAD) risk. Given limited data on this association in the Iranian population, this study assessed CAD involvement patterns among patients with and without positive familial history.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted from April 2019 to April 2020 at <em>Imam</em> Reza and Ghaem Hospitals, Mashhad, Iran. We enrolled 300 patients who presented with typical chest pain and confirmed CAD via coronary angiography. Participants were divided into two groups based on FH of CAD and evaluated for potential risk factors.</div></div><div><h3>Results</h3><div>Of 300 patients, 170 had positive FH and 130 did not. The cohort included 175 males (58.3 %) with a mean age of 54.2 years. Multivariate logistic regression identified age (OR: 1.04, <em>p</em> = 0.014), male gender (OR: 0.56, <em>p</em> = 0.035), and hypertension (OR: 1.99, <em>p</em> = 0.008) as significant differentiators between FH groups. Positive FH was independently associated with more extensive CAD, including multivessel involvement and greater severity of disease.</div></div><div><h3>Conclusion</h3><div>Positive familial history is strongly associated with increased severity and extent of CAD in Iranian patients. Incorporating FH into risk stratification can improve identification of high-risk individuals for targeted preventive and therapeutic strategies.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100609"},"PeriodicalIF":1.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesterol crystal embolization syndrome: Systemic and end-organ injury","authors":"Akanksha Mehla ,&nbsp;Yash Patel ,&nbsp;Majid Yavari ,&nbsp;Mahmoud Khairy ,&nbsp;Kevin Watat ,&nbsp;F.N.U. Parul ,&nbsp;Karuna Rayamajhi ,&nbsp;Britni Smith ,&nbsp;George S. Abela ,&nbsp;Christopher A. Hanson","doi":"10.1016/j.ahjo.2025.100612","DOIUrl":"10.1016/j.ahjo.2025.100612","url":null,"abstract":"<div><div>Cholesterol embolization syndrome (CES) is characterized by the embolization of cholesterol crystals from atherosclerotic plaques into small and medium-size arteries. It predominantly occurs spontaneously in individuals with severe atherosclerosis or following vascular interventions. The dislodgment of cholesterol crystals triggers an inflammatory cascade in the affected vessels, leading to tissue ischemia and multi-organ dysfunction. Commonly affected are the kidneys, skin, and gastrointestinal tract, although any affected, though any organ system may be involved with varied presentations often making the diagnosis challenging. CES is diagnosed based on clinical suspicion supported by laboratory findings, such as eosinophilia, elevated inflammatory markers, imaging and/or histopathological evidence of cholesterol emboli. Treatment focuses on supportive care, addressing end-organ damage, and minimizing further embolization by optimizing atherosclerotic risk factors. Anticoagulation is generally avoided unless there is an alternative indication. Statins are commonly used for their pleiotropic effects on inflammation and plaque stabilization. In conclusion, CES is an underrecognized condition with significant morbidity. A high index of suspicion is essential for early diagnosis and intervention.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100612"},"PeriodicalIF":1.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Woven solutions for tissue engineering: Next-generation heart valves from fiber to function","authors":"Cornelia Sennewald ,&nbsp;Jasmin Pilgrim ,&nbsp;Dilbar Aibibu ,&nbsp;Thomas Gereke ,&nbsp;Philipp Schegner ,&nbsp;Chokri Cherif","doi":"10.1016/j.ahjo.2025.100604","DOIUrl":"10.1016/j.ahjo.2025.100604","url":null,"abstract":"<div><h3>Study objective</h3><div>Cardiovascular diseases remain one of the leading causes of morbidity and mortality worldwide, yet the availability of durable, patient-specific heart valve replacements is still limited. The aim is to utilize a biomimetic, textile-based design to mimic natural tissues, thereby creating customizable solutions with improved mechanical properties and scalable production for cardiovascular applications.</div></div><div><h3>Design</h3><div>By leveraging advanced 3D weaving techniques, the feasibility of manufacturing anatomically adaptable and mechanically robust textile valves is demonstrated. CAD-based design workflows and functional materials such as shape memory Nitinol wires are part of this technology. The integration of form-defining geometries, multilayer structures and functional surface treatments is enabled through tailored binding design and machine adaptations.</div></div><div><h3>Main outcome and results</h3><div>A textile-based heart valve implant was developed using advanced 3D weaving, CAD modelling and patient-specific imaging. Integrated leaflets and an annular ring were formed directly during weaving using mold inserts and multilayer structures, eliminating post-processing. Polyester and Nitinol materials provided mechanical stability and shape-memory functionality. Simulation models and SPH analysis validated pressure behaviour and deformation under physiological conditions. Functional zones with tailored stiffness, sealing and mobility were realized through binding variation and Jacquard control. A reproducible digital workflow, from CT segmentation to weaving on modified looms, enabled scalable production of anatomically accurate, functionally optimized heart valve prostheses. Mechanical evaluations reveal favourable performance in comparison to conventional valve designs.</div></div><div><h3>Conclusion</h3><div>These findings highlight the potential of fiber and textile technology as a scalable, customizable clinically relevant platform for heart valve tissue engineering and future biomedical applications.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100604"},"PeriodicalIF":1.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal magnetocardiography: Using quantum technologies to define fetal rhythm, conduction, and repolarization prior to birth","authors":"Janette F. Strasburger","doi":"10.1016/j.ahjo.2025.100593","DOIUrl":"10.1016/j.ahjo.2025.100593","url":null,"abstract":"<div><div>The timeframe of fetal development holds many risks, and mortality is higher than at almost any other time in the human life-cycle. To date, echocardiography has dominated fetal cardiac assessment. Since the 1990's, the potential value of fetal magnetocardiography (fMCG) as a means of recording the fetal rhythm and cardiac time intervals (RR, P, PR, QRS, QT, QTc) has been appreciated. Over the intervening 3 decades, well over 1000 fetal studies have been performed in pregnancies with various high-risk conditions, the majority with fetal arrhythmias or congenital heart disease. Most studies to date have been performed using Superconducting Quantum Interference Device (SQIUD) magnetometers within a magnetically-shielded room (MSR). Since 2015, a new type of quantum device called an Optically-pumped magnetometer (OPM) has been introduced. These small sensors can be assembled for multichannel recording. OPMs do not require cryogenics, dramatically reducing the potential cost of a system, and thus allowing for the concept of a “person-sized shield rather than a full-sized MSR. Yet no OPM systems are yet FDA approved for the fetus. This contemporary review will summarize the current and future use of fMCG in the clinical and research setting and will compare fetal MCG by OPM with that of SQUID. Challenges to commercialization will be discussed.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100593"},"PeriodicalIF":1.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk","authors":"Catarina Porto ,&nbsp;Katia Petribu ,&nbsp;Nathalia Barbosa ,&nbsp;Rayana Magalhães ,&nbsp;Cecília Lira ,&nbsp;Ana Beatriz Porto ,&nbsp;Brivaldo Markman-Filho ,&nbsp;Andrea Lordsleem ,&nbsp;Eveline Calado ,&nbsp;José Magalhães ,&nbsp;Everton Sougey ,&nbsp;Tatiana Silva ,&nbsp;Aluísio Junio ,&nbsp;Francisco Bandeira ,&nbsp;Rita Leão","doi":"10.1016/j.ahjo.2025.100599","DOIUrl":"10.1016/j.ahjo.2025.100599","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the contributions of vitamin D supplementation to the control of cardiovascular risk factors and the treatment of depressive symptoms, including suicide risk.</div></div><div><h3>Methods</h3><div>A randomized, placebo-controlled, double-blind clinical trial was conducted with 224 adults (18–61 years) diagnosed with major depressive disorder, recruited from psychiatric clinics of two universities in Northeast Brazil. Participants were randomized to receive vitamin D supplementation (50,000 IU/week; <em>n</em> = 112) or placebo (n = 112) for six months. Assessments included depressive symptoms, suicide risk, clinical/laboratory cardiovascular parameters, and serum vitamin D at baseline and day 180. Statistical analysis used chi-squared or Fisher's exact test, McNemar's test, Student's <em>t</em>-test or Mann-Whitney test, with odds ratios (OR) and 95 % confidence intervals (CI). Significance level was set at 5 %.</div></div><div><h3>Results</h3><div>Vitamin D supplementation significantly increased serum concentrations to adequate physiological levels and led to marked reductions in depressive symptoms (<em>p</em> = 0.001) and suicide risk (p = 0.001). Additionally, 13 of 15 evaluated cardiovascular risk factors showed normalization or significant reduction, without adverse events related to calcium metabolism or other side effects. Improvements included better lipid profile, glycemic control, and inflammatory markers. Clinically, these findings suggest potential for vitamin D as an adjuvant therapy in depression management, contributing to both mental health and cardiometabolic stability.</div></div><div><h3>Strengths and limitations</h3><div>Strengths include the rigorous double-blind, randomized design, probabilistic sampling, and comprehensive clinical-laboratory evaluation. Limitations involve the single-region sample, lack of long-term follow-up after supplementation, and the exclusion of patients with severe comorbidities, which may limit generalizability.</div></div><div><h3>Conclusion</h3><div>Weekly administration of 50,000 IU of vitamin D for six months proved effective in reducing depressive symptoms and suicide risk while improving cardiovascular health markers, highlighting its promise as an accessible, low-cost adjunctive therapy in psychiatric and primary care settings.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100599"},"PeriodicalIF":1.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telemedicine for the detection and management of in-hospital and out-of-hospital sudden cardiac arrest: Status quo and quo vadis","authors":"Aman Goyal ,&nbsp;Darshan Puttaswamy ,&nbsp;Esha Kadam ,&nbsp;Surabhi Maheshwari ,&nbsp;Sonia Hurjkaliani ,&nbsp;Priya Goyal ,&nbsp;Kamya Thakkar ,&nbsp;Viraj Shah ,&nbsp;Mohamed Daoud ,&nbsp;Gauranga Mahalwar","doi":"10.1016/j.ahjo.2025.100600","DOIUrl":"10.1016/j.ahjo.2025.100600","url":null,"abstract":"<div><div>Telemedicine has revolutionised healthcare by enabling the remote delivery of medical services through secure communication technologies. In cardiology, telemedicine has become invaluable for early diagnosis, emergency care, and chronic disease management, addressing challenges like cost and geographic barriers. Sudden cardiac arrest (SCA), a leading cause of mortality, represents a potential area for telemedicine application, though evidence supporting its direct impact on survival remains limited. Despite resuscitation advancements, SCA survival remains under 5 %, primarily due to delayed diagnosis and treatment. Emerging tools—such as wearable sensors, mobile applications, and artificial intelligence—show promise in early warning sign detection; however, most studies remain preliminary, and large-scale validation is lacking.</div><div>In cases of in-hospital cardiac arrest, telemedicine supports real-time consultations with remote experts. It facilitates adherence to clinical protocols, reduces treatment delays, and integrates cognitive aids to optimize resuscitation efforts. However, existing trials have yielded mixed results, and questions remain regarding feasibility, staffing models, and effective integration during acute events. Telemedicine strengthens the “chain of survival” for out-of-hospital cardiac arrest through telecommunicator cardiopulmonary resuscitation (CPR), boosting bystander CPR rates and improving survival chances. Nevertheless, concerns about added delays, first-responder coordination, and variability in system infrastructure remain critical barriers. Post-resuscitation, telemedicine networks enable evidence-based interventions such as targeted temperature management, demonstrating feasibility and effectiveness in emergency settings. Moreover, remote monitoring of pacemakers and implantable cardioverter defibrillators ensures timely care while reducing outpatient clinic burdens. Integrating artificial intelligence enhances telemedicine's potential by enabling personalized care and predictive analytics. However, limited physical examinations, technical issues, and data privacy concerns persist. Furthermore, restricted physical examinations, infrastructure limitations, and data privacy risks continue to hinder the broader adoption of telemedicine. While telemedicine holds potential to reduce mortality in high-risk scenarios like SCA, its current utility is constrained by technological, logistical, and systemic barriers. Continued research, targeted implementation strategies, and evidence-based integration into emergency care pathways are essential to realize its transformative promise.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"59 ","pages":"Article 100600"},"PeriodicalIF":1.8,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of lipid profile and high sensitive C reactive protein levels among cigarette smokers in East Gojjam, Ethiopia","authors":"Gelagey Baye ,&nbsp;Bayu Wondmneh ,&nbsp;Baye Ashenef ,&nbsp;Mohammed Jemal ,&nbsp;Temesgen Baylie ,&nbsp;Enyew Fenta Mengistu ,&nbsp;Adane Adugna","doi":"10.1016/j.ahjo.2025.100601","DOIUrl":"10.1016/j.ahjo.2025.100601","url":null,"abstract":"<div><h3>Introduction</h3><div>Cigarette smoking is a well-recognized independent risk factor for numerous cardiovascular disorders and contributes to the increasing morbidity and mortality associated with chronic heart diseases (CHD). This study aimed to evaluate how cigarette smoking affects lipid metabolism and inflammatory processes, along with other related mechanisms, in order to better understand the potential cardiovascular risks faced by smokers.</div></div><div><h3>Objectives</h3><div>To evaluate and compare the serum lipid profile and high-sensitivity C-reactive protein levels between cigarette smokers and non-smokers.</div></div><div><h3>Methods</h3><div>A hospital-based comparative cross-sectional study was conducted from December 2023 to May 2024 in East Gojjam, Ethiopia. The study included 150 cigarette smokers and 150 non-smokers. Independent <em>t</em>-tests and ANOVA were used to compare the mean lipid profiles and high-sensitivity C-reactive protein levels between smokers and non-smokers. A <em>p</em>-value of &lt;0.05 was considered statistically significant.</div></div><div><h3>Result</h3><div>The mean serum levels of total cholesterol, low-density lipoprotein, triglycerides, high-density lipoprotein, and high-sensitivity C-reactive protein in cigarette smokers were 178.46 ± 76.34 mg/dL, 112.36 ± 73.58 mg/dL, 138.80 ± 61.88 mg/dL, 38.33 ± 7.99 mg/dL, and 6.26 ± 5.53 mg/L, respectively. These values were significantly different from those of non-smokers (<em>p</em>-value &lt;0.05).</div></div><div><h3>Conclusion</h3><div>Serum mean levels of total cholesterol, low-density lipoprotein, triglycerides, and high-sensitivity C-reactive protein were significantly higher in cigarette smokers compared to non-smokers. In contrast, the mean serum level of high-density lipoprotein was significantly lower in smokers. These changes—elevated TC, LDL-C, TG, and hsCRP, along with decreased HDL-C—may increase the risk of cardiovascular diseases among cigarette smokers.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"58 ","pages":"Article 100601"},"PeriodicalIF":1.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Letter to the Editor regarding “Clinical benefit and cost effectiveness of adding life-time low-dose colchicine as secondary prevention following coronary artery bypass grafting surgery”’ [Am. Heart J. Plus Cardiol. Res. Pract. Vol. 58, 2025, 100591]","authors":"Parth Aphale ,&nbsp;Himanshu Shekhar ,&nbsp;Shashank Dokania","doi":"10.1016/j.ahjo.2025.100598","DOIUrl":"10.1016/j.ahjo.2025.100598","url":null,"abstract":"","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"58 ","pages":"Article 100598"},"PeriodicalIF":1.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}