Cardiovascular risk factor burden and adverse pregnancy outcomes in women with cardiovascular disease

IF 1.8 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

American heart journal plus : cardiology research and practice Pub Date : 2025-09-11 DOI:10.1016/j.ahjo.2025.100611

Valerie C. Nemov , Alden Dunham , Claudio Schenone Giugni , Viviana De Assis , Emily Coughlin , Mary Ashley Cain , Judette M. Louis , Daniela R. Crousillat

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Abstract

Introduction

We investigated associations between pre-conception cardiovascular risk factor burden and adverse pregnancy outcomes (APOs) in women with cardiovascular disease (CVD).

Methods

We created a patient registry from our cardio-obstetrics program. APOs were defined as intrauterine growth restriction (IUGR), hypertensive disorder of pregnancy (HDP), and pre-term birth.

Results

Analysis included 63 women. 42 (66.7 %) experienced no APOs, while 21 (33.3 %) did; 18 (28.6 %), 3 (4.8 %), and 12 (19.0 %) developed an HDP, IUGR, or delivered pre-term, respectively. Pre-conception risk burden was not a significant predictor of APO development (p = 0.139). However, patients with pre-term delivery had a significantly higher number of risk factors (p < 0.001), as did patients with chronic hypertension with superimposed HDP (p < 0.001).

Discussion

Women delivering pre-term have higher risk factor burdens. Since pre-term birth is associated with future CVD in women independent of cause, optimization of preconception cardiovascular health could help mitigate these risks in an already vulnerable population.

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心血管疾病妇女的心血管危险因素负担和不良妊娠结局

我们研究了患有心血管疾病（CVD）的女性孕前心血管危险因素负担与不良妊娠结局（APOs）之间的关系。方法：我们从我们的心脏产科项目创建了一个患者注册表。apo被定义为宫内生长受限（IUGR）、妊娠高血压障碍（HDP）和早产。结果共纳入63名女性。无apo 42例（66.7%），有apo 21例（33.3%）；分别有18例（28.6%）、3例（4.8%）和12例（19.0%）发生HDP、IUGR或早产。孕前风险负担不是APO发生的显著预测因子（p = 0.139）。然而，早产患者的危险因素数量明显较高（p < 0.001），合并HDP的慢性高血压患者也是如此（p < 0.001）。早产妇女有更高的风险因素负担。由于早产与女性未来的心血管疾病无关，因此优化孕前心血管健康有助于减轻已经脆弱的人群的这些风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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