Alpha psychiatry最新文献

{"title":"Factor Analysis of the BDI-II and HAMD-21 in Patients With Irritable Bowel Syndrome.","authors":"Akaki Burkadze, Eka Burkadze, Tamar Kandashvili, Teimuraz Silagadze","doi":"10.31083/AP44020","DOIUrl":"10.31083/AP44020","url":null,"abstract":"<p><strong>Objective: </strong>The factorial validity of the Beck Depression Inventory-II (BDI-II) and the 21-item Hamilton Depression Rating Scale (HAMD-21) in individuals with Irritable Bowel Syndrome (IBS) has not yet been investigated. This study aimed to assess the factor structure of these instruments and analyze their interrelationships within the Georgian IBS population.</p><p><strong>Methods: </strong>Principal component analysis was performed on data from 89 IBS patients. Factors were determined using eigenvalues ≥1, with factor loadings exceeding 0.4 and oblique rotations identifying factor compositions. The Kaiser-Meyer-Olkin measure, Cronbach's alpha, Bartlett's test, communality, non-redundant residuals, and the component correlation matrix were used to assess factor validity. Intercorrelations between the scales' symptoms were also analyzed.</p><p><strong>Results: </strong>The mean BDI-II score was 24.31 (standard deviation (SD) = 14.93) and the mean HAMD-21 score was 17.38 (SD = 8.91). According to the cutoff criteria for both scales, the sample exhibited moderate depression. The BDI-II identified three factors, while the HAMD-21 revealed four distinct factors. Combined analysis showed that most BDI-II items and core depressive symptoms from HAMD-21 clustered into Component I. Component II included four HAMD-21 items: insomnia (delayed), agitation, somatic anxiety, and insight. Significant positive correlations between paired BDI-II and HAMD-21 symptoms were found, with a high correlation (r = 0.88, <i>p</i> = 0.000) between the scales, differing from previous findings.</p><p><strong>Conclusion: </strong>The high correlations within components, along with low non-redundant residuals and high communality, indicate satisfactory factor validity for both the BDI-II and HAMD-21. The self-report BDI-II inventory and the HAMD-21 scale are complementary in evaluating depressive symptoms in patients with IBS.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"44020"},"PeriodicalIF":1.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Psychoeducation-Based Model Group Work in Continuous Treatment of Patients With Bipolar Disorder in Remission.","authors":"Xuemin Shi, Suilin Jia, Lingkai Yang, Zhipeng Yin, Bowen Yin, Guangdong Chen","doi":"10.31083/AP43989","DOIUrl":"10.31083/AP43989","url":null,"abstract":"<p><strong>Objective: </strong>To explore the value of psychoeducation-based group work in the continuous treatment of patients with bipolar disorder in remission.</p><p><strong>Methods: </strong>From December 2020 to March 2022, 60 outpatients with remission-stage bipolar disorder were enrolled in the trial. All enrolled subjects were randomly and single-blindly divided into a study group and a control group at a 1:1 ratio. The control group was treated with general drug therapy, while the study group was treated with group psychological education combined with drug therapy. To analyze the treatment adherence of patients in the two groups, and to compare the changes in self-awareness and attitude toward treatment questionnaire (ITAQ) scale scores, Morisky medication adherence scale scores, Self-rating Depression Scale (SDS) total scores, and subscale scores before and after the intervention in the two groups.</p><p><strong>Results: </strong>The mean score for treatment compliance in the study group was 4.2 ± 0.3, which was significantly higher than that in the control group (4.2 ± 0.3 <i>vs</i>. 3.2 ± 0.5, <i>p</i> < 0.001). The ITAQ score in the study group following the intervention was significantly higher than that in the control group (18.5 ± 3.2 <i>vs</i>. 12.7 ± 2.7, <i>p</i> < 0.001), as well as the study group prior to the intervention (<i>p</i> < 0.001). Morisky scale scores after intervention were significantly higher than those in the control group (6.9 ± 1.0 <i>vs</i>. 5.5 ± 0.8, <i>p</i> < 0.001) and the study group before intervention (<i>p</i> < 0.001). Sheehan Disability Scale 1 (SDS1), SDS2, SDS3, and SDS scores after intervention were 8.5 ± 1.2, 8.0 ± 1.5, 7.9 ± 2.0, and 25.5 ± 4.3, respectively, all of which were significantly higher than those in the control group (all <i>p</i> < 0.001). The proportion of positive coping style for bipolar disorder in the study group was significantly higher than that in the control group (93.3% <i>vs</i>. 50.0%, <i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>Continuous intervention using psychoeducation-based model group work in patients with bipolar disorder in the remission stage can significantly improve treatment compliance, improve insight and treatment attitudes, ensure compliance with drug therapy, and reduce the degree of mental disability.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"43989"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Communications Reveal Social Aversion in Rats With Contact Motivation Deficits but not Anhedonia.","authors":"Anastasiya A Rebik, Nadezda D Broshevitskaya, Vyacheslav D Riga, Pavel L Aleksandrov, Maria I Zaichenko, Inna S Midzyanovskaya","doi":"10.31083/AP43990","DOIUrl":"10.31083/AP43990","url":null,"abstract":"<p><strong>Objectives: </strong>Animal models of human diseases are commonly used in experimental research. Autism Spectrum Disorder (ASD) is characterized by reduced social motivation and often co-occurs with epilepsy, representing a distinct clinical subgroup. This study investigated social deficits in Krushinsky-Molodkina (KM) rats, which present with latent epilepsy and an autistic-like phenotype, by measuring ultrasonic communications during social interaction.</p><p><strong>Methods: </strong>The three-chamber test for social preference/novelty, accompanied by registration of ultrasonic vocalizations (USVs), was conducted in 12 KM and 12 control Wistar rats. For analysis, each individual vocalization trajectory was mapped and the results were derived from aggregating the individual data. To assess potential anhedonia, sucrose preference was tested in a separate group (10 KM and 20 Wistar rats) by measuring the consumption of 1% sucrose and water in individual rats over a 24-h period. All animals used were seizure-naive males, aged 4-6 months.</p><p><strong>Results: </strong>A longer duration of aversive USV calls was registered during the sociability tests in KM rats (<i>p</i> < 0.05, compared with controls). The majority (<i>p</i> < 0.05) of aversive USVs occurred when KM rats distanced themselves from the social stimuli, and the duration of these calls showed a positive correlation with freezing behavior (Spearman coefficient Rs = 0.68, <i>p</i> < 0.05). Reduced sucrose preference was not observed in KM rats; instead, an increase in daytime sucrose consumption was noted.</p><p><strong>Conclusions: </strong>KM rats exhibit negative emotional states in sociability tests, as evidenced by enhanced aversive vocalizations and distancing behavior. The social aversion observed in KM rats is not associated with anhedonia.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"43990"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network Specificity in Predicting Childhood Trauma Characteristics Using Effective Connectivity.","authors":"Shufei Zhang, Wei Zheng, Zezhi Li, Huawang Wu","doi":"10.31083/AP43988","DOIUrl":"10.31083/AP43988","url":null,"abstract":"<p><strong>Background: </strong>Childhood maltreatment (CM) has become one of the leading psychological stressors, adversely impacting brain development during adolescence and into adulthood. Although previous studies have extensively explored functional connectivity associated with CM, the dynamic interaction of brain effective connectivity (EC) is not well documented.</p><p><strong>Methods: </strong>Resting-state functional magnetic resonance imaging data were collected from 215 adults with an assessment using the Childhood Trauma Questionnaire (CTQ). Whole-brain EC was estimated by regression dynamic causal modeling and subsequently down-resampled into seven networks. To predict CTQ total scores, repeated cross-validated ridge-regularized linear regression was employed, with whole-brain and network-specific EC features selected at thresholds of 5% of the strongest positive and negative correlations between EC and scores, as well as 10% and 20% thresholds. Additionally, a least absolute shrinkage and selection operator (LASSO)-regularized linear regression model was utilized as validation analysis.</p><p><strong>Results: </strong>Our findings revealed that whole-brain EC showed a marginal association with predicting CTQ total scores, and EC within the default mode network (DMN) significantly predicted these scores. EC features from other networks did not yield significant predictive results. Notably, across varying feature selection thresholds, DMN features consistently demonstrated significant predictive power, comparable to results from LASSO-regularized predictions.</p><p><strong>Conclusions: </strong>These findings suggested that brain EC can capture individual differences in CM severity, with the DMN potentially serving as an important predictor related to CM.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"43988"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network Analysis of Parental-Economic Factors and Symptoms of Suicidal Ideation Among Left-Behind Children in Unprivileged Regions in China.","authors":"Yang Yu, Qianyu Zhang, Xuerong Liu, Mengjie Luo, Xiaolin Zhang, Xianyong An, Jingxuan Zhang","doi":"10.31083/AP43496","DOIUrl":"10.31083/AP43496","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate relationships between parental-economic factors and suicidal ideation among left-behind children in underprivileged regions of China using network analysis, to pinpoint key factors and pathways contributing to suicidal ideation, thereby facilitating evidence-based suicide preventive interventions.</p><p><strong>Methods: </strong>In total, 1076 left-behind children were selected from a large dataset (N = 249,772) after applying exclusion criteria. Suicidal ideation was assessed via the Positive and Negative Suicide Ideation Inventory-Chinese Version (PANSI-C). The outcomes were grouped into positive suicidal ideation and negative suicidal ideation within the network analysis framework. Sociodemographic data, parental status, and economic status were also recorded. Through network analyses, centrality and bridge indices were calculated. Network stability and accuracy were evaluated by bootstrapping methods.</p><p><strong>Results: </strong>The network had three communities: positive suicidal ideation, negative suicidal ideation, and covariates. Strong positive correlations were observed within communities, especially among \"life worth\", \"confident\", and \"satisfy\". Nodes \"failure\", \"lonely and sad\", \"confident\", and \"satisfy\" exhibited the highest expected influence. Nodes \"hopeless\", \"life worth\", and \"satisfaction of family members' relationships\" served as bridges between the covariates and suicidal ideation. Significant structural differences existed between female and male networks.</p><p><strong>Conclusions: </strong>This study highlights the multifaceted nature of suicidal ideation among left-behind children, which is influenced by various parental-economic factors. Key node and bridge links offer targets for tailored interventions. Gender-sensitive approaches are imperative in suicide preventive measures. Network analysis provides a comprehensive framework to unravel complex relationships, informing evidence-based interventions for left-behind children.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"43496"},"PeriodicalIF":1.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arabic Perspectives on Classification of Psychotic Disorders: A Historical Overview and Comparison With Contemporary Classifications.","authors":"Homayun Shahpesandy","doi":"10.31083/AP43494","DOIUrl":"10.31083/AP43494","url":null,"abstract":"<p><p>This paper explores the perspectives of Arabic-scribing medical schools on the classification of psychotic disorders of the Middle Ages, the so-called \"Islamic Golden Age\". Through an in-depth analysis of seminal texts in Arabic medical literature, including works by renowned scholars such as Tabari, Razi, Avicenna, and others, this paper elucidates the historical development of psychiatric taxonomy in the Arabic medical tradition. By examining the representations of \"junun\" (\"madness\") or psychoses in these texts and comparing them with earlier European and current classifications, we aim to highlight the unique contributions of Arabic-scribing scholars to the field of clinical psychiatry. The Arabic taxonomy divides \"junun\" (\"insanity\") into three major categories of (1) permanent insanities (\"al-junun al-thābet\"), (2) symptomatic illnesses (\"a'rāz tābea-tul amrāz\"), and (3) reactive. Arabic medical schools consider \"insanity\" as a primary brain pathology albeit with multifactorial etiology-a concept formulated by early Greco-Roman medicine, developed by Muslim physicians, and re-invented by Griesinger in the 19th century-known as the \"organic model\" of mental illnesses.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"43494"},"PeriodicalIF":1.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balance Control in Children and Youth with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.","authors":"Wenhong Xu, Niuniu Li, Jing Qi","doi":"10.31083/AP42869","DOIUrl":"10.31083/AP42869","url":null,"abstract":"<p><strong>Background: </strong>Compared with typically developing (TD) children and youth, those with autism spectrum disorder (ASD) present more balance deficits. However, the understanding of which specific balance areas are affected remains incomplete at present.</p><p><strong>Methods: </strong>Relevant studies were searched in PubMed, Web of Science Core Collection, Scopus and EBSCO from the establishment of the database to March 17, 2024. Two reviewers independently screened the literature, extracted data and assessed the methodological quality of the included studies. Meta-analysis was performed through Review Manager software, and a narrative description of the results was used if the data could not be pooled for meta-analysis.</p><p><strong>Results: </strong>A total of 16 studies were included, with six being suitable for meta-analysis. The research indicated that individuals with ASD showed poorer balance control compared with TD peers. Specifically, the ASD group faced significant difficulties in sensory orientation and demonstrated deficiencies in verticality and anticipatory postural adjustments.</p><p><strong>Conclusions: </strong>Children and youth with ASD exhibit impairments in balance control across different domains compared with their TD peers. More research is needed to comprehensively assess the balance control construct in this population, including studies with longitudinal designs in particular.</p><p><strong>The prospero registration: </strong>The protocol of this systematic review was registered with the International Prospective Register of Systematic Reviews (registration no. CRD42024553855; registration date 15 June 2024; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024553855).</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"42869"},"PeriodicalIF":1.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Executive Function in the Co-occurrence of ADHD and Developmental Dyscalculia in Chinese Children.","authors":"Jing Zhang, Min Dong, Lu Liu, Sunwei Qiu, Meirong Pan, Xinlin Zhou, Qiujin Qian","doi":"10.31083/AP42712","DOIUrl":"10.31083/AP42712","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to elucidate the characteristics of executive function deficits in children with Attention-deficit/hyperactivity disorder (ADHD) comorbid with developmental dyscalculia (ADHD+DD).</p><p><strong>Methods: </strong>Three groups of Chinese children (n = 637) aged from 6 to 16 years were included in this study. Initially, a between-group comparison on both performance-based and scale-based executive function was conducted, controlling for age, Raven score, and gender. Partial correlation analysis and regression analysis were then used to investigate the association between executive function, ADHD symptoms, and arithmetic ability. Furthermore, logistic regression analysis and path analysis were used to differentiate the effect of executive functions on ADHD without developmental dyscalculia (ADHD-DD) and ADHD+DD.</p><p><strong>Results: </strong>Both ADHD groups had more severe executive function impairment than the control group. Compared with the ADHD-DD group, the ADHD+DD group performed worse in performance-based executive functions but similar in scale-based executive functions. ADHD-DD and ADHD were differentiated by inhibition (odds ratio (OR) = 2.00, 95% CI = 1.42; 2.81) and processing speed (OR = 0.90, 95% CI = 0.84; 0.97). In terms of symptom dimensions, verbal working memory had an effect on ADHD symptoms and complex subtraction (<i>p_Ina</i> = 0.006, <i>p_HI</i> = 0.018, <i>p_CS</i> = 0.002), processing speed (<i>p_Ina</i> = 0.002, <i>p_CS</i> = 0.001) and working memory factors influenced inattention and complex subtraction (<i>p_Ina</i> < 0.001, <i>p_CS</i> = 0.001), and inhibition (<i>p</i> = 0.004) and cognitive flexibility (<i>p</i> = 0.013) contributed uniquely to complex subtraction.</p><p><strong>Conclusion: </strong>Individuals with ADHD+DD exhibit multiple executive function deficits, with inhibition and processing speed being potential etiological factors. Verbal working memory, processing speed, and working memory factors are shared executive function deficits for ADHD symptoms and arithmetic ability. Cognitive flexibility and inhibition are specific risk factors for arithmetic ability.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"42712"},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Did Serendipity Contribute to the Discovery of New Antidepressant Drugs? Historical Analysis Using Operational Criteria.","authors":"Francisco López-Muñoz, Pilar D'Ocón, Alejandro Romero, Domenico De Berardis, Cecilio Álamo","doi":"10.31083/AP40037","DOIUrl":"https://doi.org/10.31083/AP40037","url":null,"abstract":"<p><strong>Objective: </strong>Given their great importance, as one of the most prescribed types of therapeutic drugs worldwide, we have analyzed the role of serendipity in the discovery of new antidepressants, ranging from selective serotonin reuptake inhibitors to more contemporary developments.</p><p><strong>Methods: </strong>We carried out a historical analysis of the discovery of new antidepressants, resorting to the original articles published on their development (initial pharmacological and clinical information) and applied an operational criterion of serendipity developed by our group.</p><p><strong>Results: </strong>Selective serotonin reuptake inhibitors (fluoxetine, fluvoxamine, citalopram, paroxetine, sertraline, and escitalopram), selective dopamine and noradrenaline reuptake inhibitors (bupropion), noradrenaline and serotonin reuptake inhibitors (venlafaxine, milnacipram, duloxetine, and desvenlafaxine), selective noradrenaline reuptake inhibitors (reboxetine), noradrenergic and specific serotonergic antidepressants (mirtazapine), melatonergic agonists (agomelatine), and serotonin modulators and stimulators (vortioxetine, vilazodone, tianeptine) correspond to the type IV pattern. Moclobemide, a reversible monoamine oxidase inhibitor, corresponds to the type II pattern, for which the initial serendipitous findings (i.e., the chance discovery of the inhibitory effects of monoamine oxidase (MAO) whilst being studied for their antihyperlipidemic properties) led to subsequent non-serendipitous discoveries (clinical antidepressant efficacy). Ketamine, a glutamatergic modulator, corresponds to the type III pattern, characterized by a non-serendipitous origin (initial development as an anesthetic agent) leading to a serendipitous observation (the discovery of antidepressant efficacy in individuals illicitly using).</p><p><strong>Conclusion: </strong>The majority of new antidepressants adhere to a type IV pattern, characterized by a rational and targeted design process where serendipity played no part, except moclobemide (type II pattern) and ketamine (type III pattern).</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 2","pages":"40037"},"PeriodicalIF":1.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Ziprasidone Injection vs Haloperidol Injection for Agitation in Patients with Acute Schizophrenia.","authors":"Sufang Qi, Wenjie Li, Limin Yang, Guangwei Sun, Xinming Li, Xin Liu, Zhicheng Xue, Yue Zhang, Guanglei Xun","doi":"10.31083/AP40032","DOIUrl":"https://doi.org/10.31083/AP40032","url":null,"abstract":"<p><strong>Objective: </strong>Agitation represents a serious and prevalent symptomatology within acute schizophrenia. This study aims to conduct a nuanced comparison of the efficacy and safety profiles of intramuscular (IM) ziprasidone versus IM haloperidol in the management of agitation among patients with acute schizophrenia.</p><p><strong>Methods: </strong>This investigation was structured as a randomized, 3-day study, utilizing flexible dosing strategies. It included 69 patients diagnosed with schizophrenia, who were randomly allocated to receive either IM ziprasidone (n = 35, 20 to 40 mg/day) or IM haloperidol (n = 34, 5 to 10 mg/day). The primary endpoints included comparative analyses of the change in Positive and Negative Syndrome Scale (PANSS) total scores and Positive and Negative Syndrome Scale Excited Component (PANSS-EC) scores from baseline to study completion across the two groups.</p><p><strong>Results: </strong>At baseline, there were no significant differences between the IM ziprasidone and haloperidol groups. Both treatments led to significant reductions in PANSS-EC total scores (haloperidol, <i>p</i> = 0.001; ziprasidone, <i>p</i> = 0.001) and PANSS total scores (haloperidol, <i>p</i> = 0.001; ziprasidone, <i>p</i> = 0.001) from baseline to study endpoint. Nevertheless, no significant difference was observed between the two groups in terms of changes in PANSS-EC scores (<i>p</i> = 0.312) and PANSS total scores (<i>p</i> = 0.159) from baseline to endpoint. The haloperidol group exhibited a higher incidence of adverse events compared with the ziprasidone group, reaching statistical significance (<i>p</i> = 0.027).</p><p><strong>Conclusions: </strong>Our findings indicate that both medications are equally effective in controlling agitation symptoms. However, ziprasidone exhibited superior characteristics in safety and tolerability, particularly in reducing the incidence of extrapyramidal symptoms.</p><p><strong>Clinical trial registration: </strong>The study was registered at https://www.chictr.org.cn/showproj.html?proj=246996, registration number: ChiCTR2500100002, date of registration: 1 April 2025.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 2","pages":"40032"},"PeriodicalIF":1.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}