Alpha psychiatry最新文献

{"title":"Comparison of Gut Microbiota in Two Different Maternal Exposure Models of Autism Spectrum Disorder in Mice.","authors":"Qiang Zhang, Xuying Pang, Min Guo, Yuezhu Wang, Yu Xu, Quan Li, Huajun Zheng","doi":"10.31083/AP38790","DOIUrl":"10.31083/AP38790","url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with unknown etiology and unclear pathogenesis. Although construction of animal models of ASD using chemical exposure during pregnancy is a mature technique, the gut microbiota of these exposure models induced using different chemicals in mice have not been compared.</p><p><strong>Methods: </strong>To compare the effects of exposure to different chemicals during pregnancy on the composition of gut microbiota in offspring, we treated Institute of Cancer Research (ICR) mice with lipopolysaccharide (LPS) and valproic acid (VPA) during pregnancy to construct different offspring ASD mouse models. After successful model construction, the gut microbiota of these models were studied.</p><p><strong>Results: </strong>After adjusting for the random effects of the litter, the two groups showed a significant reduction in social time (social deficits) and an increase in self-grooming behaviors (repetitive and stereotyped behaviors). Gut microbiota analysis revealed significant changes, mostly a decrease, in the abundance of four phyla, 52 genera, and 41 species in the two types of ASD models. Several different gut microbes could be related to the development of ASD.</p><p><strong>Conclusions: </strong>Chemicals exposure during pregnancy induces ASD-related behavioral abnormalities in offspring mice. Importantly, exposure to different chemicals during pregnancy produces varying degrees of effects on gut microbiota composition in offspring ASD models. This finding can provide a reference for studies on the etiology and pathogenesis of ASD.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38790"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family Intensive Behavioral Intervention for Children with Autism Spectrum Disorder: A Half-Year Comparison-Controlled Study.","authors":"Yi Wu, Xueping Chen, Duo Li, Hongwu Wang, Yan Ou, Shaoyuan Su, Guimin Liu, Qingying Zhang, Wenwang Rao","doi":"10.31083/AP38796","DOIUrl":"10.31083/AP38796","url":null,"abstract":"<p><strong>Objective: </strong>Family intervention is a crucial component of treatment for children with autism spectrum disorder (ASD), yet the impact of parent-mediated family-intensive behavioral intervention on the language abilities of children with ASD has been barely studied. The purpose is to investigate the effectiveness of the Verbal Behavior Milestones Assessment and Placement Program (VB-MAPP)-based family-intensive behavioral intervention in enhancing the language abilities of children with ASD. This study provides insights to help ASD children better cope with daily life.</p><p><strong>Methods: </strong>From September 2020 to September 2022, a total of 85 clinically diagnosed children with ASD and 30 age- and sex-matched children without ASD were recruited. Applied Behavior Analysis (ABA) and VB-MAPP were used for evaluating and determining individualized intervention programs for children with ASD. The intervention lasted 6 months.</p><p><strong>Results: </strong>There were no significant differences in demographic characteristics between children with ASD and children without ASD (all <i>p</i> > 0.05), except for the mother's age. After the intervention, there was a significant increase in all VB-MAPP scores among children with ASD (all <i>p</i> < 0.001), compared with the baseline VB-MAPP total score and 16 domain scores. Tests of noninferiority showed that children with ASD at post-intervention were non-inferior to children without ASD in the Visual Perceptual Skills and Matching-to-Sample (VP/MTS) score (<i>p</i> = 0.001), play score (<i>p</i> = 0.034), reading score (<i>p</i> < 0.001), and writing score (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Family-intensive behavioral intervention significantly improved the skills of children with ASD, as assessed by the VB-MAPP. These findings emphasize the importance of family intervention and provide further support for proposing a family intervention program for children with ASD that is suitable for China's national conditions.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38796"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurosyphilis Diagnosis and Treatment in Psychiatric Hospitals: A Retrospective Study.","authors":"Yajie Wang, Zhili Hu, Heping Zheng, Xiaolin Qin, Changchang Li, Hui Zhang, Lianhong Zheng, Wujian Ke","doi":"10.31083/AP38794","DOIUrl":"10.31083/AP38794","url":null,"abstract":"<p><strong>Background: </strong>Neurosyphilis, caused by <i>Treponema pallidum</i> invading the nervous system, can lead to severe neurological complications across all stages of syphilis. Misdiagnosis is common, exacerbated by overlapping psychiatric conditions and diagnostic limitations. This study aims to improve the understanding and management of neurosyphilis in psychiatric settings to enhance diagnostic accuracy and treatment efficacy.</p><p><strong>Methods: </strong>A retrospective study used data from the Chinese Case Report System (CCRS) spanning 2014-2018. Four municipal psychiatric hospitals in Guangdong were chosen based on syphilis rates and psychiatric patient volumes. Sociodemographic data, syphilis history, symptoms, diagnostic and treatment details, and laboratory results were reviewed. The Brief Psychiatric Rating Scale (BPRS) assessed psychopathology symptoms. Treatment efficacy was evaluated using BPRS scores before and after standard treatment. Diagnoses followed national guidelines, with statistical analyses performed using logistic regression and <i>t</i>-tests.</p><p><strong>Results: </strong>Out of 69,436 psychosis patients screened, 1588 were diagnosed with syphilis, with 262 (16.5%) of these cases identified as neurosyphilis. Syphilis prevalence mildly declined from 2.8% (2014) to 2.0% (2016), while neurosyphilis cases increased marginally from 0.34% (2014) to 0.39% (2018). Confirmatory Cerebrospinal Fluid (CSF) tests were conducted in only 30.2% of neurosyphilis cases. Standard therapy was administered to 66.8% of patients, with significantly better outcomes in confirmed cases (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Diagnosing and treating neurosyphilis in Guangdong's psychiatric hospitals remains challenging. Accurate diagnosis and standardized treatment protocols are essential to effectively manage both syphilis and associated mental health complications caused by neurosyphilis.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38794"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FYN Tyrosine Kinase Gene Polymorphisms in Alcohol-Dependent Korean Patients.","authors":"Sung Young Huh, Sung-Gon Kim, Ji-Hoon Kim, Hyeon-Kyeong Kim, Yeon-Sue Kim","doi":"10.31083/AP38752","DOIUrl":"10.31083/AP38752","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use disorder (AUD) is a common disease with a high economic cost. The glutamate cell signaling pathway associated with alcohol has been reported to be one of the main pathologies of AUD. Previous studies have suggested that <i>FYN</i>, which is known to control NMDA glutamate receptor function through phosphorylation, might be associated with AUD.</p><p><strong>Method: </strong>The present study included 354 subjects in the alcohol-dependent group and 139 subjects in the control group. The alcohol-dependent group was recruited from five university hospitals and a psychiatric hospital, and the control group was recruited from people who visited the university hospital for routine medical checkups in Korea. <i>FYN</i> gene single nucleotide polymorphism (SNPs) were selected based on SNP databases and previous studies of the <i>FYN</i> gene. Ten SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism techniques.</p><p><strong>Results: </strong>GG genotypes and G allele frequencies of rs1058134 in male AUD patients were significantly lower than in controls (<i>p</i> = 0.003). AA genotypes and A allele frequencies of rs12191154 in female AUD patients were significantly lower than in controls (<i>p</i> < 0.001, <i>p</i> = 0.003). In female AUD patients, AA genotypes and A allele frequencies of rs9387025 were significantly higher than in controls (<i>p</i> = 0.003).</p><p><strong>Conclusion: </strong>These findings suggest that the <i>FYN</i> gene may be a candidate gene for AUD. This may help for the planning of further studies to determine the function of each SNP and the exact relationship between the <i>FYN</i> gene and AUD.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38752"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocircuitry and Neuroanatomy in Panic Disorder: A Systematic Review.","authors":"Peter Kyriakoulis, Clarissa Wijaya, Laiana Quagliato, Rafael C Freire, Antonio E Nardi","doi":"10.31083/AP38756","DOIUrl":"10.31083/AP38756","url":null,"abstract":"<p><strong>Background: </strong>This review updates our understanding of the neuroanatomical and neurocircuitry factors involved in panic disorder (PD). Many aspects remain undetermined.</p><p><strong>Methods: </strong>Clinical studies and a randomized controlled trial were identified via PubMed database and included in this review.</p><p><strong>Results: </strong>The search, following PRISMA guidelines, identified 13 human studies and 3 animal studies. Nine human studies compared brain activity and connectivity between regions in PD patients. Neural activity in the amygdala was highlighted in six studies. The hippocampus had higher activation in PD patients compared to those with social phobia, but generally showed less activity compared to healthy controls. The parahippocampal gyrus and thalamus exhibited greater activation in PD patients than healthy controls. Activity in the prefrontal cortices was also noted, particularly the ventromedial prefrontal cortex (vmPFC), ventrolateral prefrontal cortex (vlPFC), dorsomedial prefrontal cortex (dmPFC), and dorsolateral prefrontal cortex (dlPFC). Other regions involved included the dorsal midbrain, left brainstem (showing hyperactivation), S1, and right caudate, which showed increased activity in PD patients. The left intraparietal sulcus (IPS) exhibited hypoactivation in response to predictable cues compared to unpredictable or neutral cues within the default mode network (DMN). Three animal studies suggested that electrical and chemical activation of the dorsal periaqueductal gray (dPAG) in rats elicited fight-or-flight behaviors, providing a model for panic attacks.</p><p><strong>Conclusions: </strong>Neuroimaging studies suggest several key regions involved in PD pathophysiology, including the brainstem, amygdala, hippocampus, parahippocampal gyrus, thalamus, insula, and prefrontal and cingulate cortices. Hypersensitivity in the brainstem and amygdala plays a role in activating the fear network. Further prospective studies are needed to identify the neuroanatomical sites involved in PD and fear circuitry.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38756"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Association between Diabetes Distress and Personality Traits: Insights from the Alternative DSM-5 Model for Personality Disorders.","authors":"Judita Konečná, David Lacko, Eva Horová, Karel D Riegel","doi":"10.31083/AP38760","DOIUrl":"10.31083/AP38760","url":null,"abstract":"<p><strong>Objective: </strong>Little is known about the association between subjectively experienced levels of diabetes distress (DD) and personality traits (PTs), even when levels of DD appear stable over time. This study aimed to use the Alternative Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Model for Personality Disorders (AMPD) to associate specific maladaptive PTs with experienced DD and to describe differences in the constellation of PTs between people with type 1 diabetes (PWT1D) and type 2 diabetes (PWT2D).</p><p><strong>Methods: </strong>A total of 358 participants with diabetes mellitus (DM) (56.2% female, mean age 42.33 years, standard deviation (SD) = 14.33) were evaluated using the Diabetes Distress Scale (DDS) and the shortened 160-item version of the Personality Inventory for DSM-5 (PID-5). Psychometric properties of the DDS were evaluated first, then the association between DDS and PID-5 scores, and the differences between groups based on diabetes type and DD level, were analyzed.</p><p><strong>Results: </strong>Strong associations were found between the PID-5 Negative Affectivity (NEF) domain and the emotional burden (β = 0.852, <i>p</i> _Holm < 0.001) and regimen distress (β = 0.435, <i>p</i> _Holm = 0.006) DDS subscale scores. PWT1D had a higher level of personality pathology than PWT2D, as did participants with elevated levels of DD across most domains and facets of PID-5.</p><p><strong>Conclusions: </strong>Our findings suggest that attention should be paid to the level of NEF among people with diabetes in relation to their emotional burden and perception of regimen distress. We recommend a distinction between people based on their diabetes type. Implications for clinical practice and interventions for DD perceived through the lens of the dimensional DSM-5 PT model are discussed.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38760"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Correlates of Depressive Symptoms and Cognitive Impairment in Elderly People over 65 Years Old in the Community and Nursing Homes.","authors":"Jie Zhang, Ying Zhang, Junjiao Ping, Jiali Luo, Haifeng Huang, Yanzhen Ren, Tingyun Jiang, Xinxia Liu","doi":"10.31083/AP38788","DOIUrl":"10.31083/AP38788","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive impairment and depression significantly reduce quality of life in the aging population. This study aimed to investigate the prevalence of depressive symptoms and cognitive impairment and explore its relationship in the elderly.</p><p><strong>Methods: </strong>A total of 1645 elderly people in nursing homes and 4703 elderly people in the community were enrolled in the survey. The Patient Health Questionnaire-9 and Ascertain Dementia-8 were employed to evaluate depressive symptoms and cognitive impairment.</p><p><strong>Results: </strong>The overall prevalence of cognitive impairment was 12.5% in the community-dwelling group and 52.2% in the nursing home group. The prevalence of cognitive impairment in nursing homes was significantly higher than that in community-dwelling groups for the same age group (<i>p</i> < 0.001). The overall prevalence of depressive symptoms was 3.9% in the community-dwelling group and 2.0% in the nursing home group. The prevalence of depressive symptoms increased with age in the community-dwelling group (<i>p</i> < 0.001). The binary logistic regression results showed that the type of care mode affected the prevalence of cognitive impairment, and the elderly in nursing homes had a high risk of cognitive impairment (odds ratio [OR] = 3.528, 95% confidence interval [CI]: 2.209-5.635, <i>p</i> < 0.001); depressive symptoms had a significant positive correlation with the odds of cognitive impairment (OR = 1.854, 95% CI: 1.052-3.266, <i>p</i> < 0.05); and the cognitive impairment rate increased with age (OR = 1.412, 95% CI: 1.044-1.910, <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>There was an increased prevalence in cognitive impairment as well as depressive symptoms in the aging population in Zhongshan city. Population-based mental health strategies need to be urgently implemented for the aging.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38788"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in the Association between Social Support and Major Depression: A Mediation Analysis with Interoception Mediator.","authors":"Yuqing Wu, Meichen Lu, Xiaohong Liu, Yifan Sun, Zhenhe Zhou, Hongliang Zhou","doi":"10.31083/AP38763","DOIUrl":"10.31083/AP38763","url":null,"abstract":"<p><strong>Background: </strong>Social support is recognized as a critical factor in both the prevention and management of Major depression Disorder (MDD), and can influence interoceptive processes. The mechanism of sex differences in the association between social support and MDD has not been clarified. This study was to elucidate the mechanism of sex differences in the association between social support and MDD by a mediation analysis with interoception mediator.</p><p><strong>Methods: </strong>Participants included 390 depressed patients (male/female: 150/240). Social Support Rating Scale (SSRS) was used to assess the degree of social support; Multidimensional Assessment of Interoceptive Awareness (MAIA-2C) was used to evaluate the interoception; Patient Health Questionnaire-9 (PHQ-9) was used to assess depression status. The pairwise correlated variables were put into the mediation model for the mediation analysis.</p><p><strong>Results: </strong>The depression status in female depressed patients was more severity than that in male depressed patients, while the social support in female depressed patients was less than that in male depressed patients. In male depressed patients, the Noticing of MAIA-2C plays a partial mediating role in social support and depression status, however, in female depressed patients, the Self-Regulation and Trusting of MAIA-2C plays a partial mediating role in social support and depression status.</p><p><strong>Conclusions: </strong>The female depressed patients receive significantly less social support than male counterparts, contributing to more severe symptoms, with the quality and adequacy of social support being crucial due to its mediation by interoception, highlighting a biological mechanism behind MDD. Differences in how interoception mediating role between genders suggest a physiological reason for the heightened severity of depressive symptoms in females.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38763"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application of China's Proactive Health Management Model for Community-Dwelling Elderly in Mental Health.","authors":"Huang Lin, Shujuan Xiao, Jinguo Zhai, Chichen Zhang","doi":"10.31083/AP38787","DOIUrl":"10.31083/AP38787","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38787"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive Negative Thinking is Associated With Depression and Feeding Status at 3 and 6 Months Postpartum: Retrospective Study.","authors":"Chunfeng Xing, Guoxin Li, Guangqing Zhang, Yaxin Liu, Meirong Yan, Guilin Liu","doi":"10.31083/AP38795","DOIUrl":"10.31083/AP38795","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between repetitive negative thinking and depression as well as feeding status at 3 and 6 months postpartum.</p><p><strong>Method: </strong>One hundred and twenty-eight pregnant women recruited by the hospital from January 2020 to June 2022 were selected for the study. General demographic data of pregnant women, the multiple Persistent Thinking Questionnaire (PTQ), the Edinburgh Postnatal Depression Scale (EPDS) at 3 and 6 months postpartum, and breastfeeding status were collected. According to PTQ scores, the pregnant women were divided into high subgroup (scores ≥30) and low subgroup (scores <30). Intergroup comparisons of continuous variables following a normal distribution were performed using the <i>t</i>-test, while categorical data were analyzed using the χ² test. Spearman correlation analysis was conducted to examine the relationship between PTQ, EPDS, and breastfeeding status.</p><p><strong>Results: </strong>EPDS scores were higher in the high group than in the low group at 3 and 6 months postpartum (<i>p</i> < 0.001). The breastfeeding rates in the high group were lower than that in the low group at 3 and 6 months postpartum (<i>p</i> < 0.001). Higher PTQ scores were associated with postpartum depression at 3 and 6 months (r = 0.379, <i>p</i> < 0.001; r = 0.358, <i>p</i> < 0.001) and lower breastfeeding rates (r = -0.346, <i>p</i> < 0.001; r = -0.353, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Higher PTQ scores are associated with increased postpartum depression and reduced breastfeeding rates at 3 and 6 months postpartum, suggesting that repetitive negative thinking may be related to postpartum mental health and feeding outcomes.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38795"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}