Alpha psychiatry最新文献

{"title":"Comparison of Brain Function Between Medication-Naïve ADHD with and without Comorbidity in Chinese Children Using Resting-State fNIRS.","authors":"Wenjing Liao, Haimei Li, Qinwei Liu, Longfei Cao, Lingli Leng, Jie Yu, Ningning Liu, Qiujin Qian, Guannan Bai","doi":"10.5152/alphapsychiatry.2024.241674","DOIUrl":"10.5152/alphapsychiatry.2024.241674","url":null,"abstract":"<p><strong>Background: </strong>This study used functional near-infrared spectroscopy (fNIRS) to investigate brain activation patterns in children with attention deficit hyperactivity disorder (ADHD) with and without additional comorbidities to identify disease-related biomarkers by the neuroimaging that will facilitate to make a diagnosis decision.</p><p><strong>Methods: </strong>In this study, 165 medication-naive children aged 7 to 15 years were recruited and categorized into four groups: ADHD, ADHD with learning disabilities (ADHD&LD), ADHD with oppositional defiant disorder (ADHD&ODD), and healthy controls. A multichannel fNIRS system was used to monitor hemodynamic changes at rest state in the prefrontal and temporal lobes of the brain. The amplitude of a low-frequency fluctuation (ALFF) matrix was calculated by summation and averaging of the square root of the signal power spectrum. One-way analysis of variance was used to identify statistical differences between channels.</p><p><strong>Results: </strong>All ADHD children presented significantly higher ALFF values in different brain regions when compared with the healthy controls. Patients with ADHD&LD exhibited higher ALFF values in the medial prefrontal cortex (<i>P</i> _Ch38 = .01, <i>P</i> _Ch48 = .01), temporal cortex (<i>P</i> _Ch22 = .04, <i>P</i> _Ch41 = .002, <i>P</i> _Ch51 = .001), and the left ventrolateral prefrontal cortex (<i>P</i> _Ch39 = .0009, <i>P</i> _Ch50 = .001), whereas ADHD&ODD children were not significantly different to those diagnosed with ADHD.</p><p><strong>Conclusions: </strong>ADHD with learning disabilities (LD) possessed a different pathogenesis from ADHD, manifested as lower functional brain activity in the medial prefrontal cortex, temporal cortex, and the left ventrolateral prefrontal cortex, while ADHD&ODD did not present significant changes compared with ADHD. ODD-related symptoms may be part of ADHD symptoms rather than being an independent disorder.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"485-492"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Comorbid Depressive Symptoms and Diabetes Mellitus on Functional Dyspepsia in Older Patients.","authors":"Zhen-Peng Huang, Yan-Bin Chen, Bin-Bin Wen, Hui-Xian Guan, Bin Wu","doi":"10.5152/alphapsychiatry.2024.241584","DOIUrl":"10.5152/alphapsychiatry.2024.241584","url":null,"abstract":"<p><strong>Objective: </strong>Diabetes mellitus (DM) is a global epidemic; comorbid depressive symptoms are highly prevalent worldwide and commonly manifests as physical symptoms, including functional dyspepsia (FD), a gastrointestinal psychosomatic disorder. This study aimed to explore the effects of comorbid depressive symptoms and DM on FD in older patients.</p><p><strong>Methods: </strong>In total, 420 older patients with DM completed measures of depression, anxiety, and FD. Relevant demographic characteristics and medical information were self-reported and obtained from the hospital information system.</p><p><strong>Results: </strong>Among older patients with DM, 30.48% had depressive symptoms. Patients with depressive symptoms were more likely to have FD than those without (42.19% vs. 20.21%, <i>P</i> = .000). Dyspepsia symptoms were more frequent in patients with depression (<i>P</i> = .022). The greater the amount of dyspepsia symptoms, the higher the depression symptoms score (<i>P</i> = .000). Furthermore, dyspepsia symptoms were positively correlated with depressive symptoms (<i>r</i> values were 0.292, 0.311, 0.297, 0.369; all had <i>P</i> < .05). Both FD subtypes, postprandial distress, and epigastric pain syndromes affected depressive symptoms (<i>P</i> < .05). Smoking was significantly associated with FD (<i>P</i> < .05). Diabetes mellitus complications, such as diabetic neuropathy, different therapeutic methods, and anxiety symptoms, influenced FD overlap (<i>x</i> ² values were 6.298, 16.314, and 30.744; <i>P</i> < .05). Anxiety (odds ratio = 1.832, 95% Confidence Intervals (CI) 1.185-2.834) was a risk factor for FD in comorbid depressive symptoms and diabetes (<i>P</i> < .05).</p><p><strong>Conclusion: </strong>Comorbid depressive symptoms and DM overlapped with physical symptoms, such as FD, in older patients with DM. Lifestyle, diabetic factors, and anxiety were the associated risk factors.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"465-471"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antisocial Behavior and Antisocial Personality Disorder Among Youth in Ethnic Minority Areas in China: A Cross-sectional Study.","authors":"Qiao Zhou, Yu Wan, Jianhua Wang, Liying Yang, Fang Shen, Qinmin Ni, Qiu Tan, Liting Dong, Jing Yang, Hong Peng, Shixiao Zhang, Jibiao Huang, Xueyan Gao, Yanfen Fu","doi":"10.5152/alphapsychiatry.2024.241622","DOIUrl":"10.5152/alphapsychiatry.2024.241622","url":null,"abstract":"<p><strong>Objective: </strong>Antisocial behavior and antisocial personality disorder (ASPD) cause serious harm to society and families. Ethnicity may have an impact on an individual's antisocial behavior and the incidence of ASPD. Therefore, this study aimed to investigate the current status of antisocial behavior and ASPD among youth and its correlation with ethnicity in ethnic minority areas in China.</p><p><strong>Methods: </strong>A total of 2475 Chinese youth (1794 under 18 and 681 greater than or equal to 18) were recruited from December 1 to 30, 2021, in Yunnan, China. All participants completed a General Information Questionnaire and the Personality Diagnostic Questionnaire Fourth Edition Plus (PDQ-4+). Associations between antisocial behavior and ASPD and sociodemographic factors such as ethnicity were examined using binary logistic regression analysis.</p><p><strong>Results: </strong>The positive rate of antisocial behavior screening in youth was 5.4% (95% CI (confidence interval): 4.3-6.4), with a positive rate of ASPD screening of 4.4% (95% CI: 2.9-6.0). Male, single-child and maternal education level at senior high school and above were risk factors for positive antisocial behavior screening, while senior high school grade and medium subjective family economic status were protective factors for positive antisocial behavior screening. Being male and paternal educational background were risk factors for positive ASPD screening.</p><p><strong>Conclusion: </strong>This study found high rates of positive screening for antisocial behavior and ASPD in youth and no significant differences in ethnicity. These results can be used to inform personality development.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"526-532"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of Acute Psychological Stress on the Emotions of Individuals with Early Life Stress.","authors":"Sunya Reddy, Madhuri Molleti, Li Li","doi":"10.5152/alphapsychiatry.2024.231435","DOIUrl":"10.5152/alphapsychiatry.2024.231435","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to evaluate negative and positive emotional responses to acute psychological stress in individuals with early life stress (ELS).</p><p><strong>Methods: </strong>One hundred sixty-one participants from the Birmingham community in Alabama completed the study and were stratified into 2 groups based on measurements of ELS using the Childhood Trauma Questionnaire and a confirmatory clinical interview. Acute psychological stress, that is, the Trier Social Stress Test (TSST), was administered, and emotional responses were measured using the Visual Analogue Scale. Comparisons utilized chi-square for categorical variables and <i>t</i>-test for continuous variables. Analysis of covariance (ANCOVA) was applied to compare the 2 groups after controlling for confounding variables. Stepwise multiple linear regression analysis was used to investigate predictive power of variables for emotional responses to the TSST.</p><p><strong>Results: </strong>Participants with ELS experienced less pleasantness at the baseline (<i>P</i> = .02), and 1 minute (<i>P</i> = .04), but not 90 minutes time points compared to the non-ELS group. Participants in the ELS group also reported higher anxiety at baseline (<i>P</i> = .003), and 90 minutes (<i>P</i> = .04) post-TSST. Data analysis showed the effect of time on emotional responses during the TSST. Different emotional responses, including pleasantness, anxiety, fatigue, and vigor, were able to be predicted by ELS severity.</p><p><strong>Conclusion: </strong>Our data demonstrates that individuals with ELS presented different positive and negative emotional responses when exposed to acute psychological stress. Our findings may be useful for clinicians who work with individuals with ELS. Our findings also highlight the importance of recognizing emotional responses and of building up resilience in response to acute stress.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"513-518"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of Sibling Relations on Sociality, Communication, and Autism Severity in Children with Autism Spectrum Disorder: A Retrospective Analysis.","authors":"Hyun-Woo Park, Bum-Sung Choi, Byung-A Song, Ji-Hoon Kim","doi":"10.5152/alphapsychiatry.2024.241645","DOIUrl":"10.5152/alphapsychiatry.2024.241645","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the differences in sociality, communication, and autism severity in children with autism spectrum disorder (ASD) according to the presence or absence of siblings, the number of siblings, the order of birth, and the sex of sibling.</p><p><strong>Methods: </strong>We included 71 children with autism spectrum disorder who visited University Hospital as outpatients. We compared the communication and socialization scores using the Korean Version of the Vineland Adaptive Behavior Scale, second edition (K-VABS II); social interaction, communication, and language using the autism diagnostic interview-revised (ADI-R); and the total score of the Korean-Childhood Autism Rating Scale 2 (K-CARS 2) according to the presence or absence of siblings, the number of siblings, the order of birth and the sex of sibling. Data were evaluated with independent <i>t</i>-tests and analysis of variance (ANOVA) tests.</p><p><strong>Results: </strong>The patient's average age was 48.8 ± 13.6 months. There was a significant difference in the total score of K-CARS-2 according to the sex of siblings. The male sibling group was 34.36 ± 6.11 and the female sibling group was 30.29 ± 6.41 points, respectively.</p><p><strong>Conclusion: </strong>This result indicates that the quality of sibling interactions in families with a child with ASD may play a significant role in reducing ASD severity and improving the quality of sibling interactions, rather than the number of siblings alone affecting the social interactions of children with ASD.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"548-554"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression, Anxiety, and Stress Among Chinese People During the Omicron Outbreak and Its Impact on Sleep Quality and Alcohol Dependency.","authors":"Md Zahir Ahmed, Oli Ahmed, Sang Hanbin, Pei Xie, Mary C Jobe, Weijian Li","doi":"10.5152/alphapsychiatry.2024.241574","DOIUrl":"10.5152/alphapsychiatry.2024.241574","url":null,"abstract":"<p><strong>Objective: </strong>The present study aims to assess the mental health of Chinese people during the Omicron variant outbreak in March 2022. This study also explores how coronavirus disease 2019 (COVID-19) exposure history, vaccination status, sleep quality, and alcohol dependency symptoms influence mental health outcomes.</p><p><strong>Methods: </strong>The data were collected from 1049 Chinese people through Tencent using a structured questionnaire utilizing convenience sampling technique. The online cross-sectional study included the Chinese version of the Depression, Anxiety and Stress Scale 21, the Alcohol Use Disorder Identification Test, Fear of COVID-19 Scale, Warwick Edinburgh Mental Well-being Scale, and Pittsburgh Sleep Quality Index to assess depression, anxiety, stress, alcohol dependency, fear of COVID-19, and sleep quality, respectively. Statistical analyses included independent sample <i>t</i>-tests and <i>χ</i> ² tests to assess the differences in study variables across demographic characteristics, and multiple linear regressions to assess the effect of the experience of COVID-19 infection, vaccination, and mental health variables on sleep quality and alcohol dependency.</p><p><strong>Results: </strong>Results showed that 11.5% to 32.4% of the participants had a poor mental health symptoms. Males had significantly higher depressive symptoms (<i>χ</i> ² = 12.283, df = 4, <i>P</i> = .015) and alcohol dependency symptoms (<i>χ</i> ² = 66.604, df = 3, <i>P</i> < .001), and females had significantly lower mental well-being (<i>χ</i> ² = 12.742, df = 2, <i>P</i> = .002). Additionally, findings showed that stress (<i>β</i> = .250, <i>P</i> < .001), mental well-being (<i>β</i> = -.166, <i>P</i> < .001), and fear of COVID-19 (<i>β</i> = .061, <i>P</i> = .029) predicted poorer sleep quality, and anxiety (<i>β</i> = .115, <i>P</i> = .035) and mental well-being (<i>β</i> = -.097, <i>P</i> = .002) predicted alcohol dependency symptoms.</p><p><strong>Conclusion: </strong>Since the pandemic-induced mental health challenges persist for a prolonged period, the findings of these relationships offer guidance for mental health professionals to formulate therapeutic interventions to help people cope with psychological crises.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 3","pages":"329-336"},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11322709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Huo Li Su Oral Solution Combined with Zopiclone in the Treatment of Insomnia Symptoms.","authors":"Lin Cong, Zili Zhou","doi":"10.5152/alphapsychiatry.2024.231352","DOIUrl":"10.5152/alphapsychiatry.2024.231352","url":null,"abstract":"<p><strong>Objective: </strong>Insomnia is a common symptom in subhealthy states. In patients, long-term insomnia symptoms can lead to decreased immune function, even mental depression, thus seriously affecting quality of life. Therefore, this study aims to observe the therapeutic effect of huo li su (HLS) oral solution combined with zopiclone in the treatment of insomnia to find suitable drugs for treatment.</p><p><strong>Methods: </strong>A total of 161 patients with insomnia from January 2017 to March 2022 were selected in this retrospective cohort study. The patients were divided into the observation (82 cases, receiving HLS oral solution and zopiclone) and control (79 cases, receiving zopiclone alone) groups in accordance with therapeutic drug administration. The differences in the scores of the 2 groups on the Sleep Disorder Scale (SDRS), Pittsburgh Sleep Quality Index (PSQI), Fatigue Inventory 14 (FS-14), and traditional Chinese medicine (TCM) syndromes before and after treatment were compared.</p><p><strong>Results: </strong>No significant differences in age, gender, disease duration, body mass index (BMI), and other general data were found between the 2 groups (<i>P ></i> .05). The TCM syndrome, PSQI, FS-14, and SDRS scores before treatment of the 2 groups were not significantly different (<i>P</i> < .05). After 4 weeks of treatment, the TCM syndrome, PSQI, FS-14, and SDRS scores of the observation group were significantly lower than those of the control group.</p><p><strong>Conclusion: </strong>HLS oral solution combined with zopiclone can effectively improve insomnia symptoms and is superior to zopiclone alone.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 3","pages":"369-374"},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11322733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Nurse-led Telepsychological Intervention for Patients with Postpartum Depression: A Systematic Review and Meta-analysis.","authors":"Ting Luo, Zhenyu Zhang, Juan Li, YanJun Li, Wendan Xiao, Yanxi Zhou, Qian Jing, Lihong Zhao","doi":"10.5152/alphapsychiatry.2024.231492","DOIUrl":"10.5152/alphapsychiatry.2024.231492","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to systematically evaluate the therapeutic effect of nurse-led telepsychological intervention on patients with postpartum depression.</p><p><strong>Methods: </strong>PubMed, Embase, CINAHL, Web of Science, the Cochrane Library, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang Database, and China VIP database were searched for articles on the effectiveness of remote psychological intervention in improving postpartum depression. The search time was limited from the establishment of the database to December 2023. The literature was screened, and data were extracted. The Cochrane risk of bias assessment tool was used to evaluate the quality of randomized controlled trials that met standards, and RevMan5.4 was used for meta-analysis.</p><p><strong>Results: </strong>A total of 14 studies involving 1765 patients from 9 countries were included. Meta-analysis results showed that compared with routine care, telepsychological intervention can alleviate maternal depression (Standard Mean Difference [SMD] = -0.60, 95% CI [-0.91, -0.29], <i>I</i> ² = 88%, <i>P</i> < .01). Sensitivity and subgroup analyses revealed that 3 studies using the Edinburgh Postpartum Depression Scale evaluation tool were the source of heterogeneity in the meta-analysis.</p><p><strong>Conclusion: </strong>Telepsychological postpartum depression intervention can effectively improve postpartum depression, indicating that it has a certain clinical application value.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 3","pages":"304-311"},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11322730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory Structural Equation Modeling Analysis of the Anxiety Sensitivity Index 3.","authors":"Young-Jin Lim","doi":"10.5152/alphapsychiatry.2024.241520","DOIUrl":"10.5152/alphapsychiatry.2024.241520","url":null,"abstract":"<p><strong>Objective: </strong>Anxiety sensitivity is associated with the onset and progression of various emotional disorders. The Anxiety Sensitivity Index 3 (ASI-3) is a self-report scale for anxiety sensitivity. This study aims to resolve the ongoing controversy about the factorial structure of the ASI-3 using exploratory structural equation modeling (ESEM), a newly advanced technique.</p><p><strong>Methods: </strong>Confirmatory factor analysis (CFA), ESEM, bifactor-CFA, and bifactor-ESEM were used to investigate the factorial structure of the ASI-3. Three hundred Korean college students (female = 195, age: 21.74 ± 2.34) filled out the ASI-3 and the Distress Intolerance Index.</p><p><strong>Results: </strong>The bifactor-ESEM model exhibited a model fit superior to the 4 alternative models. The general factor showed higher loadings and reliability and explained common variance than the 3 specific factors in the bifactor-ESEM model. Most items reflected the global factor, but 6 items (Items 2, 3, 5, 7, 10, and 17) from the specific factors had insufficient loadings. Moreover, the global factor of the ASI-3 was associated with distress intolerance scores, indicating adequate criterion-related validity.</p><p><strong>Conclusion: </strong>The factorial structure of the ASI-3 is best described as a bifactor-ESEM model for Korean college students. Additionally, the bifactor-ESEM model of the ASI-3 includes a strong global factor that explains a large amount of the observed variance in the ASI-3 items.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 3","pages":"337-343"},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11322669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of 3' Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia.","authors":"Xiaoyun Guo, Xinqun Luo, Xiaoyi Huang, Yong Zhang, Jiawu Ji, Xiaoping Wang, Kesheng Wang, Jijun Wang, Xinghua Pan, Bin Chen, Yunlong Tan, Xingguang Luo","doi":"10.5152/alphapsychiatry.2024.241616","DOIUrl":"10.5152/alphapsychiatry.2024.241616","url":null,"abstract":"<p><strong>Objective: </strong>Schizophrenia is often associated with volumetric reductions in cortices and expansions in basal ganglia, particularly the putamen. Recent genome-wide association studies have highlighted the significance of variants in the 3' regulatory region adjacent to the kinectin 1 gene (<i>KTN1</i>) in regulating gray matter volume (GMV) of the putamen. This study aimed to comprehensively investigate the involvement of this region in schizophrenia.</p><p><strong>Methods: </strong>We analyzed 1136 single-nucleotide polymorphisms (SNPs) covering the entire 3' regulatory region in 4 independent dbGaP samples (4604 schizophrenia patients vs. 4884 healthy subjects) and 3 independent Psychiatric Genomics Consortium samples (107 240 cases vs. 210 203 controls) to identify consistent associations. Additionally, we examined the regulatory effects of schizophrenia-associated alleles on <i>KTN1</i> mRNA expression in 16 brain areas among 348 subjects, as well as GMVs of 7 subcortical nuclei in 38 258 subjects, and surface areas (SA) and thickness (TH) of the entire cortex and 34 cortical areas in 36 936 subjects.</p><p><strong>Results: </strong>The major alleles (<i>f</i> > 0.5) of 25 variants increased (<i>β</i> > 0) the risk of schizophrenia across 2 to 5 independent samples (8.4 × 10^-4 ≤ <i>P</i> ≤ .049). These schizophrenia-associated alleles significantly elevated (<i>β</i> > 0) GMVs of basal ganglia, including the putamen (6.0 × 10^-11 ≤ <i>P</i> ≤ 1.1 × 10^-4), caudate (8.7 × 10^-4 ≤ <i>P</i> ≤ 9.4 × 10^-3), pallidum (<i>P</i> = 6.0 × 10^-4), and nucleus accumbens (<i>P</i> = 2.7 × 10^-5). Moreover, they potentially augmented (<i>β</i> > 0) the SA of posterior cingulate and insular cortices, as well as the TH of frontal (pars triangularis and medial orbitofrontal), parietal (superior, precuneus, and inferior), and temporal (transverse) cortices, but potentially reduced (<i>β</i> < 0) the SA of the whole, frontal (medial orbitofrontal), and temporal (pole, superior, middle, and entorhinal) cortices, as well as the TH of rostral middle frontal and superior frontal cortices (8.9 × 10^-4 ≤ <i>P</i> ≤ .050).</p><p><strong>Conclusion: </strong>Our findings identify significant and functionally relevant risk alleles in the 3' regulatory region adjacent to <i>KTN1</i>, implicating their crucial roles in the development of schizophrenia.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 3","pages":"413-420"},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11322729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}