Alpha psychiatry最新文献

{"title":"The Use and Evaluation of Long-acting Injectable Antipsychotic Medications in Community-Dwelling Patients with Schizophrenia in Guangdong Province, China.","authors":"Shi-Bin Wang, Wenyan Tan, Xiao-Yang Fu","doi":"10.5152/alphapsychiatry.2024.241591","DOIUrl":"10.5152/alphapsychiatry.2024.241591","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"561-563"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Bipolar Disorder I and II: Clinical Features, Comorbidities, and Pharmacological Pattern.","authors":"Andrea Aguglia, Gabriele Giacomini, Clio F De Michiel, Nicolò Garbarino, Alessio Lechiara, Caterina Magni, Matteo Meinero, Edoardo Verrina, Alessandra Costanza, Andrea Amerio, Mario Amore, Gianluca Serafini","doi":"10.5152/alphapsychiatry.2024.241474","DOIUrl":"10.5152/alphapsychiatry.2024.241474","url":null,"abstract":"<p><strong>Objective: </strong>Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition provides precise diagnostic criteria to differentiate between bipolar disorder (BD) type I and II; nevertheless, it can be challenging to come up with the right diagnosis. The aim of this study is to evaluate the sociodemographic differences, clinical features, comorbidities, and pharmacological pattern between patients with BD type I and II.</p><p><strong>Methods: </strong>A total of 680 patients with BD type I and II were consecutively recruited to our psychiatry department. A semi-structured interview was used to collect several information.</p><p><strong>Results: </strong>Patients with BD type I were mostly males, single, with a lower current age, and unemployed compared to patients with BD type II. Furthermore, patients with BD type I showed an earlier age at onset and a significant higher prevalence of psychotic and residual symptoms, a higher number of hospitalizations, and involuntary admissions. On the other hand, patients with BD type II were associated with a significant higher prevalence of lifetime suicide attempts, psychiatric comorbidities, and use of alcohol. Finally, antidepressant drugs were prescribed more often to patients with BD type II, while antipsychotics and mood stabilizers were mostly prescribed in patients with BD type I.</p><p><strong>Conclusion: </strong>the differentiation of the 2 nosologic bipolar diagnosis is in line with the current scientific interest, confirming the existence of a markedly different profile between BD type I and II. This differentiation could reduce the heterogeneity of bipolar presentation in research, optimize clinical assessment, and increase the interest in developing more precise and individualized therapeutic strategies, also implementing psychosocial therapies.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"472-479"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety and Depression after Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis of Short- and Long-Term Outcomes.","authors":"Peiwen Yuan, Dong Wang, Dafei Xie","doi":"10.5152/alphapsychiatry.2024.231359","DOIUrl":"10.5152/alphapsychiatry.2024.231359","url":null,"abstract":"<p><strong>Objective: </strong>Anxiety and depression commonly afflict colorectal cancer (CRC) surgery patients, but their impact on survival remains uncertain.</p><p><strong>Methods: </strong>We systematically reviewed three databases for relevant articles. Data included study and patient characteristics, cancer type, anxiety/depression measures, timing, and prevalence. Meta-analyses, using common- or random-effects models, assessed associations. Subgroup analyses based on follow-up duration and publication bias assessment were performed.</p><p><strong>Results: </strong>We analyzed seven cohort studies, examining anxiety and depression's impact on mortality in colorectal cancer patients. Samples ranged from 215 to 567 for anxiety and 215 to 46 710 for depression. Using common- or random-effects models based on heterogeneity, anxiety and depression showed increased mortality risk. Pooled odds ratio (OR) for anxiety was 1.07 (95% CI [confidence interval] 1.05-1.10), depression's OR was 2.76 (95% CI 1.25-6.11; random-effects). Pooled hazard ratio (HR) for anxiety was 1.33 (95% CI 1.28-1.37; common-effects) and 1.30 (95% CI 1.19-1.43; random-effects). HRs for depression were 1.45 (95% CI 1.30-1.61; random-effects) and 1.28 (95% CI 1.25-1.32; common-effects). Subgroup analyses revealed stronger effects on mortality in a shorter follow-up (0-5 years) compared to a longer follow-up (5-28 years).</p><p><strong>Conclusion: </strong>This meta-analysis shows that anxiety and depression are linked to increased mortality in patients with CRC. The findings suggested that screening and treating mental distress improve survival and quality of life in this population.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"429-439"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Network Pharmacology and Molecular Docking to Explore the Mechanisms of Ningshen Wendan Decoction in the Treatment of Schizophrenia.","authors":"Chunhua Qi, Yanhua Yu, Haibing Lv, Xiaojie Ju, Xiaocui Ji, Pengfei Li, Kuanjun He","doi":"10.5152/alphapsychiatry.2024.241560","DOIUrl":"10.5152/alphapsychiatry.2024.241560","url":null,"abstract":"<p><strong>Objective: </strong>Schizophrenia (SCZ) is a prevalent chronic mental disorder characterized by a high recurrence rate and significant disability. Currently, no satisfactory pharmacological treatments have been identified. Although Ningshen Wendan decoction (NSWDD) has shown promising results in improving cognitive function in patients with schizophrenia, its underlying mechanism of action remains unclear.</p><p><strong>Methods: </strong>This study systematically investigated the mechanisms of NSWDD in SCZ treatment using network pharmacology and molecular docking approaches.</p><p><strong>Results: </strong>Analysis of the interaction genes revealed 307 common targets of NSWDD and SCZ. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses indicated the involvement of multiple signaling pathways including interleukin 17 signaling pathway, multiple virus infections, Advanced glycosylation end products (AGEs) - receptor of AGEs (AGEs-RAGE) signaling pathway, tumor necrosis factor signaling pathway, and Hypoxia-inducible factor-1 (HIF-1) signaling pathway as key pathways influenced by NSWDD in treating SCZ. These pathways are associated with various biological processes such as transcriptional regulation, apoptosis regulation, gene expression regulation, and external stimulus-response. Molecular docking simulations indicated favorable binding interactions between components of NSWDD and target proteins via intermolecular forces.</p><p><strong>Conclusion: </strong>The study provided initial insights into the internal molecular mechanisms underlying the beneficial effect of NSWDD on SCZ through multi-target modulation across multiple pathways.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"456-464"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Identity Bubble Reinforcement on the Happiness Index among Chinese Medical Staff: The Mediating Role of General Self-Efficacy.","authors":"Lingling Fan, Xiaoli Chen, Niuniu Sun, Jinli Wu, Xincheng Huang, Yang Ni, Lin Cai, Yibo Wu","doi":"10.5152/alphapsychiatry.2024.241681","DOIUrl":"10.5152/alphapsychiatry.2024.241681","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the mediating role of general self-efficacy in the influence of social media identity bubble reinforcement on the happiness index among Chinese medical staff.</p><p><strong>Methods: </strong>This study utilized data (n = 877) from the 2022 Psychological and Behavioral Investigation of Chinese Residents (PBICR) related to medical staff. Correlation analysis was performed using SPSS 26.0 software, and the relationships between general self-efficacy, social media identity bubble reinforcement, and the happiness index of Chinese medical staff were examined using AMOS 23.0 software.</p><p><strong>Results: </strong>The happiness index of Chinese medical staff was scored at 2.93 ± 1.21 for each item. Social media identity bubble reinforcement among Chinese medical staff was positively correlated with general self-efficacy (<i>r</i> = 0.380, <i>P</i> < .001), as well as with the happiness index (<i>r</i> = 0.330, <i>P</i> < .001). General self-efficacy was positively correlated with the happiness index (<i>r</i> = 0.575, <i>P</i> < .001) and was found to mediate the relationship between social media identity bubble reinforcement and the happiness index of Chinese medical staff. In terms of the mediating effect of social media identity bubble reinforcement, the direct effect's 95% confidence interval (CI) was 0.031-0.142, accounting for 34.68% of the total effect, which is statistically significant (<i>P</i> = .015), while the 95% CI of the indirect effect was 0.125-0.212, representing 65.32% of the total effect, also statistically significant (<i>P</i> = .005).</p><p><strong>Conclusion: </strong>Social media identity bubble reinforcement and general self-efficacy were found to be important factors influencing the happiness index of medical staff. Hospital managers and policymakers can thus enhance the social media identity bubble reinforcement and general self-efficacy of Chinese medical staff through effective measures to improve their happiness indices.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"519-525"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inpatient Care for Elderly Suicide Survivors: Nurse-Led Mindfulness-Based Cognitive Therapy.","authors":"Dandan Li, Mingsi Fan, Hailei Bian, Li Ni","doi":"10.5152/alphapsychiatry.2024.241519","DOIUrl":"10.5152/alphapsychiatry.2024.241519","url":null,"abstract":"<p><strong>Objective: </strong>The aim was to analyze the effects of nurse-led mindfulness-based cognitive therapy (MBCT) in hospitalized elderly suicide survivors.</p><p><strong>Methods: </strong>The data of middle-aged and elderly suicide survivors in the medical system and nursing records of our hospital from January 2018 to August 2023 were retrospectively collected. The patients were divided into conventional group and MBCT group according to whether they actively received MBCT. The general demographic data of the patients and the changes in the scores of Suicidal Ideation Scale (SSI), Beck Hopelessness Scale (BHS), Patient Health Questionnaire 15 (PHQ-15), and Geriatric Depression Scale (GDS-15) at admission and 3 and 6 months of follow-up were collected. Propensity score matching was used to balance the baseline data of the 2 groups. Multiple logistic regression analysis was used to determine the effect of the inpatient care program on each score.</p><p><strong>Results: </strong>A total of 160 patients were included in the study, including 100 patients in the MBCT group and 60 patients in the conventional group. There was no significant difference in baseline data between the 2 groups after matching (<i>P</i> > .05). Suicidal Ideation Scale score, BHS score, PHQ-15 score, and GDS-15 score in MBCT group were lower than those in conventional group at 6 months of follow-up (<i>P</i> < .05). At the same time, multiple logistic regression analysis showed that the intervention program was the main factor affecting the SSI (OR = 1.538, <i>P</i> = .010), BHS (OR = 1.614, <i>P</i> = .006), PHQ-15 (OR = 1.797, <i>P</i> = .001), and GDS-15 scores (OR = 1.642, <i>P</i> = .004) at 6 months of follow-up.</p><p><strong>Conclusions: </strong>The application of nurse-led MBCT in hospitalized elderly suicide survivors may reduce suicidal ideation, hopelessness, and depression and improve physical symptoms.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"449-455"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Causal Effects between Mood Swings and Gastrointestinal Diseases: A Mendelian Randomization Study.","authors":"Kaixin Wang, Shuai Wang, Xiangdong Chen","doi":"10.5152/alphapsychiatry.2024.241688","DOIUrl":"10.5152/alphapsychiatry.2024.241688","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies have examined the links between mental disorders such as depression and bipolar disorder, and gastrointestinal (GI) diseases. However, few studies have investigated the link between mood swings and GI diseases. Given the impact of mood swings on various conditions and the growing comprehension of the gut-brain axis, this study aims to explore their causal relationship using Mendelian randomization (MR) methods.</p><p><strong>Methods: </strong>Single-nucleotide polymorphisms (SNPs) associated with mood swings were obtained from a recent study. SNPs associated with GI diseases were identified from the FinnGen project. We conducted two-sample bidirectional MR analyses using three methods, primarily the inverse variance weighting (IVW) method. Furthermore, we performed sensitivity analyses and false discovery rate (FDR) analysis to validate the accuracy and robustness of the results.</p><p><strong>Results: </strong>Bidirectional MR analysis revealed significant causal effects between mood swings and GI diseases according to the IVW method (odds ratio (OR): 1.213; 95% confidence interval (CI): 1.118-1.316; <i>P</i> = 3.490e-6; <i>P</i> _FDR = 8.730e-5). Mood swings were linked to an increased risk for 11 of 24 diseases, including five upper GI diseases (gastroesophageal reflux disease (GERD), acute gastritis, gastroduodenal ulcer, duodenal ulcer, and functional dyspepsia), two lower GI diseases (diverticular disease of the intestine and irritable bowel syndrome (IBS)) and four hepatobiliary and pancreatic diseases (nonalcoholic fatty liver disease (NAFLD), chronic pancreatitis, acute pancreatitis, and pancreatic cancer). Inverse MR analysis showed no causal relationship between 24 GI diseases and mood swings.</p><p><strong>Conclusions: </strong>This comprehensive MR analysis suggests that genetically predicted mood swings may be a risk factor in the development of GI diseases. Interventions for mood swings may help to treat GI diseases.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"533-540"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Resistant Depression Response to Esketamine Assessing Metabolomics (ReDREAM) Project-Untargeted Metabolomics to Identify Biomarkers of Treatment Response to Intranasal Esketamine in Individuals with Treatment-Resistant Depression: A Study Protocol.","authors":"Francesco Bartoli, Daniele Cavaleri, Ilaria Riboldi, Cristina Crocamo, Renato de Filippis, Riccardo Zandonella Callegher, Giuseppe Paglia, Umberto Albert, Pasquale De Fazio, Giuseppe Carrà","doi":"10.5152/alphapsychiatry.2024.241549","DOIUrl":"10.5152/alphapsychiatry.2024.241549","url":null,"abstract":"<p><strong>Objective: </strong>Treatment-resistant depression (TRD) affects around 20-30% of people with major depressive disorder. In 2019, esketamine nasal spray was approved for TRD by both the US Food and Drug Administration and the European Medicines Agency. While its clinical efficacy and safety are proven, the mechanisms underlying its antidepressant effect remain unclear. The use of metabolomics may allow understanding the metabolic effects of esketamine and predicting biological features associated with clinical response in TRD. Nonetheless, there is a lack of studies exploring the predictive value of metabolomics. The Resistant Depression Response to Esketamine Assessing Metabolomics (ReDREAM) project aims at identifying metabolic biosignatures that may represent novel correlates of response to esketamine treatment.</p><p><strong>Study design: </strong>This is the protocol of an observational, prospective study.</p><p><strong>Methods: </strong>We plan to select 60 people with TRD from 3 clinical sites in Italy. The participants will be administered with esketamine nasal spray, following standard clinical practice, twice a week for 4 weeks (\"induction phase\"), then once a week for 4 additional weeks (\"maintenance phase\"). We will test the correlations between baseline metabolic profile and depressive symptom improvement at study endpoints (weeks 4 and 8) and we will explore the likelihood of different metabolic phenotypes between responders and non-responders.</p><p><strong>Expected results: </strong>An involvement of energy metabolism, amino acid metabolism, urea cycle, and nitric oxide synthesis in response to treatment with esketamine nasal spray is hypothesized.</p><p><strong>Conclusion: </strong>Unbiased data from untargeted metabolomics associated with clinical changes after esketamine treatment may contribute to define new paradigms for precision psychiatry-oriented, personalized care of TRD.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"555-560"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broader Open Data Needed in Psychiatry: Practice from the Psychology and Behavior Investigation of Chinese Residents.","authors":"Yuqi Yang, Siyuan Fan, Wenwen Chen, Yibo Wu","doi":"10.5152/alphapsychiatry.2024.241804","DOIUrl":"10.5152/alphapsychiatry.2024.241804","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"564-565"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid Intima-media Thickness, Arterial Stiffness and Depression.","authors":"Christian Saleh","doi":"10.5152/alphapsychiatry.2024.241784","DOIUrl":"10.5152/alphapsychiatry.2024.241784","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"25 4","pages":"566-567"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}