Alpha psychiatry最新文献

{"title":"Optimizing Cognitive Health: The Promise and Challenges of Physical-Cognitive Interventions for Dementia and Mild Cognitive Impairment.","authors":"Yingchun Zeng, Guolong Zhang","doi":"10.31083/AP38762","DOIUrl":"10.31083/AP38762","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38762"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who Are You? Views of Self as Reported by 90 Depressed Adolescent Psychiatric Inpatients.","authors":"Christopher McGovern, James C Overholser, Christiana Silva","doi":"10.31083/AP38761","DOIUrl":"10.31083/AP38761","url":null,"abstract":"<p><strong>Background: </strong>The factors contributing to adolescents' views of self can be complex and idiosyncratic. Self-esteem can hinge upon a narrow or broad set of factors, depending on how the adolescent conceptualizes the self. The present study examines how narrow and broad views of self may be differentially related to measures of depression severity and suicide risk among adolescents.</p><p><strong>Methods: </strong>In total, 90 adolescent psychiatric inpatients were evaluated while hospitalized during a major depressive episode. All patients completed the Children's Depression Inventory, the Hopelessness Scale for Children, the Rosenberg Self-Esteem Scale, and the Self-Esteem Worksheet-an idiographic measure that allows each person to rate the importance and success related to enter their personal values and priorities.</p><p><strong>Results: </strong>Compared to depressed adolescent inpatients, depressed and suicidal teens reported significantly higher levels of depression and hopelessness, along with significantly lower levels of self-esteem on both measures of self-esteem. Further, lower scores on the Self-Esteem Worksheet were associated with more severe depression, elevated hopelessness, and elevated suicidal ideation.</p><p><strong>Conclusions: </strong>The Self-Esteem Worksheet provides insights into the mind of vulnerable teens that may help to guide treatment and prevention efforts.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38761"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Privacy Protection for Open Sharing of Psychiatric and Behavioral Research Data: Ethical Considerations and Recommendations.","authors":"Yundi Zhang, Siyuan Fan, Hui Hui, Ning Zhang, Jing Li, Liping Liao, Chaofu Ke, Dan Zhang, Shihong Su, Zhiqiang Song, Yu Zhang, Qian Du, Long Liu, Lan Wang, Lijie Yang, Jia Li, Li Xu, Shiqi Xiao, Lei Shi, Xuman Xiao, Wenzhao Wang, Niuniu Sun, Qilian He, Ran Hao, Ju Wu, Zhiqiang Tian, Yanting Lou, Qiang Yao, Wai-Kit Ming, Feng Jiang, Xiaoming Zhou, Mingxu Wang, Xinying Sun, Yibo Wu","doi":"10.31083/AP38759","DOIUrl":"10.31083/AP38759","url":null,"abstract":"<p><p>Data sharing within psychiatric and behavioral research represents a novel application of ethical principles in practice; however, it suffers from a dearth of practical experience and established ethical norms. In this study, we comprehensively examined the ethical considerations surrounding the acquisition, management, sharing, and utilization of such data. We graded sensitive data and suggest ethical standards for privacy protection based on varying levels of data sensitivity. The objective of this study is to foster orderly and standardized open sharing of psychiatric and behavioral research data, thereby advancing the development and progress of related academic disciplines in China. This Chinese expert consensus has been registered on the International Guide Registration platform (Registration Number: PREPARE-2024CN412).</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38759"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Revolving Door Phenomenon in the Romanian Mental Health System.","authors":"Radu-Mihai Păun, Valentin Petre Matei, Cătălina Tudose","doi":"10.31083/AP38789","DOIUrl":"10.31083/AP38789","url":null,"abstract":"<p><strong>Background: </strong>Hospitalized at least three times in a two-year period, have emerged as an unintended side effect of the deinstitutionalization of mental health in high-income countries. Guaranteeing access to high-quality outpatient services has shown to be the most effective method for alleviating the revolving door phenomenon. In Eastern Europe, deinstitutionalization is ongoing, 0 but the phenomenon has received little attention. The present cross-sectional study examined the revolving door phenomenon in the largest psychiatric inpatient unit in Bucharest, Romania.</p><p><strong>Methods: </strong>Socio-demographic healthcare use and clinical characteristics of 144 patients were collected following admission to the \"Profesor Doctor Alexandru Obregia\" Psychiatric Hospital via an initial visit conducted between September 2022 and January 2023. A follow-up check occurred one year later to evaluate the number of readmissions and compare those who met the criteria for revolving door status at follow-up with those who did not. After identifying factors associated with revolving door status by univariate analysis, a bivariate model included the results to account for reciprocal moderating effects.</p><p><strong>Results: </strong>In total, 56 (38.9%) patients met the criteria for revolving door status. The number of lifetime hospitalizations was significantly higher in the revolving door group (odds ratio (OR) = 3.956, <i>p</i> ≤ 0.001), while involuntary admission on the initial visit decreased the odds of receiving a revolving door status on follow-up (OR = 0.188, <i>p</i> = 0.008). Revolving door patients had less time between readmissions than controls (OR = 0.991, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Frequent hospitalization was the primary factor predicting revolving door status in the cohort studied, reflecting the Romanian mental health system's focus on inpatient care. This illustrates the need for reliable outpatient care as an alternative to hospital admission to avoid the self-perpetuating cycle of repeated admissions that are inefficient both from an economic and medical standpoint.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38789"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Insomnia, Depression, and Perceived Social Support among Individuals with Amphetamine Use Disorder (AUD) and Healthy Controls.","authors":"Nasrin Abdoli, Dena Sadeghi-Bahmani, Nader Salari, Mehdi Khodamoradi, Zeno Stanga, Annette B Brühl, Serge Brand, Kenneth M Dürsteler","doi":"10.31083/AP38786","DOIUrl":"10.31083/AP38786","url":null,"abstract":"<p><strong>Background: </strong>Compared to the general population, individuals with substance use disorders (SUD) report more frequently to suffer from sleep disturbances and symptoms of depression, and to perceive lower social support. Here, we investigated whether this pattern of mental health issues could be confirmed and replicated among individuals with amphetamine use disorder (AUD). We also assessed the degree of perceived social support from their families, friends and significant others, always compared to healthy controls (HC) of the general population.</p><p><strong>Method: </strong>Individuals with AUD attending the Outpatient Department for Substance Abuse of the Kermanshah University of Medical Sciences (Kermanshah, Iran) (n = 468; 30.8% females; mean age: 29.16 years) and healthy controls (HC; n = 376; 34.6% females; mean age: 24.11 years) participated in the study. Participants completed a series of self-rating questionnaires covering sociodemographic information, symptoms of insomnia and depression, and perceived social support from their families, friends and significant others.</p><p><strong>Results: </strong>Compared to HC, individuals with AUD reported higher scores for insomnia and depression, and lower scores for perceived social support (families; friends; significant others). Older age and higher severity scores for depression and insomnia were the predictors in the binary logistic regression model to identify individuals with AUD and HC with a precision of 97.4%.</p><p><strong>Conclusions: </strong>Individuals with AUD additionally suffer from insomnia and depression, along with lower perceived social support. Given that standardized intervention programs for insomnia, depression and social competencies exist, such interventions might mitigate mental health issues among individuals with AUD and improve their psychosocial behavior.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38786"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of <i>Stmn1</i> Polymorphism and Cognitive Function: An Observational Study in the Chinese Adults.","authors":"Hui Ma, Zhengtu Cong, Lijuan Liang, Zhaoxia Su, Jing Zhang, Hua Yang, Man Wang","doi":"10.31083/AP38719","DOIUrl":"10.31083/AP38719","url":null,"abstract":"<p><strong>Background: </strong>Stathmin1 (Stmn1) is a protein highly expressed during the development of the central nervous system. The phosphorylation of Stmn1 involves microtubule dynamics, so Stmn1 plays a vital part in neurite outgrowth and synaptic plasticity. Previous studies reported that <i>Stmn1</i> genetic variants influence fear and anxiety as well as cognitive-affective processing. However, no study reported on the relationship between <i>Stmn1</i> gene polymorphism and cognition in Chinese. Thus, this association was investigated in the present study.</p><p><strong>Methods: </strong>A total of 129 healthy Han Chinese were genotyped for <i>Stmn1</i> rs182455 polymorphism by polymerase chain reaction and restriction fragment length polymorphism analyses. Cognitive function was assessed using the Stroop Color-Word Test (SCWT) and Hopkins Verbal Learning Test-Revised (HVLT-R).</p><p><strong>Results: </strong>In the present sample, rs182455 CC, CT, and TT genotypes were found in 56 (43.41%), 65 (50.39%) and 8 (6.20%) cases, respectively. The genotype distribution did not deviate from Hardy-Weinberg equilibrium (χ² = 3.715, <i>p</i> = 0.054). Significant differences were found between the three rs182455 genotypes and between the CC and (CT+TT) genotype groups in the Stroop Color (SC) scores of the SCWT (F = 3.322, 2.377; <i>p</i> = 0.039, 0.019, respectively) and the total recall (TR) scores on the HVLT-R (F = 3.118, 2.225; <i>p</i> = 0.048, 0.028, respectively). There was a female-specific difference in SC scores between the three rs182455 genotypes (F = 2.318, <i>p</i> = 0.023). The rs182455 genotype distribution showed no significant difference between two sexes (χ² = 1.313, <i>p</i> = 0.519), whereas significant differences were seen in SC and TR scores between two sexes (t = -2.294, -2.490; <i>p</i> = 0.023, 0.014, respectively).</p><p><strong>Conclusions: </strong>The findings suggest that rs182455 <i>Stmn1</i> polymorphism might affect cognitive flexibility and immediate free recall in healthy Chinese individuals, especially females.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38719"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family Intensive Behavioral Intervention for Children with Autism Spectrum Disorder: A Half-Year Comparison-Controlled Study.","authors":"Yi Wu, Xueping Chen, Duo Li, Hongwu Wang, Yan Ou, Shaoyuan Su, Guimin Liu, Qingying Zhang, Wenwang Rao","doi":"10.31083/AP38796","DOIUrl":"10.31083/AP38796","url":null,"abstract":"<p><strong>Objective: </strong>Family intervention is a crucial component of treatment for children with autism spectrum disorder (ASD), yet the impact of parent-mediated family-intensive behavioral intervention on the language abilities of children with ASD has been barely studied. The purpose is to investigate the effectiveness of the Verbal Behavior Milestones Assessment and Placement Program (VB-MAPP)-based family-intensive behavioral intervention in enhancing the language abilities of children with ASD. This study provides insights to help ASD children better cope with daily life.</p><p><strong>Methods: </strong>From September 2020 to September 2022, a total of 85 clinically diagnosed children with ASD and 30 age- and sex-matched children without ASD were recruited. Applied Behavior Analysis (ABA) and VB-MAPP were used for evaluating and determining individualized intervention programs for children with ASD. The intervention lasted 6 months.</p><p><strong>Results: </strong>There were no significant differences in demographic characteristics between children with ASD and children without ASD (all <i>p</i> > 0.05), except for the mother's age. After the intervention, there was a significant increase in all VB-MAPP scores among children with ASD (all <i>p</i> < 0.001), compared with the baseline VB-MAPP total score and 16 domain scores. Tests of noninferiority showed that children with ASD at post-intervention were non-inferior to children without ASD in the Visual Perceptual Skills and Matching-to-Sample (VP/MTS) score (<i>p</i> = 0.001), play score (<i>p</i> = 0.034), reading score (<i>p</i> < 0.001), and writing score (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Family-intensive behavioral intervention significantly improved the skills of children with ASD, as assessed by the VB-MAPP. These findings emphasize the importance of family intervention and provide further support for proposing a family intervention program for children with ASD that is suitable for China's national conditions.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38796"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myasthenia Gravis and Depression: A Multifaceted Exploration through Omics and Beyond.","authors":"Zheng Guo, Yulu Zheng, Lois Balmer","doi":"10.31083/AP38754","DOIUrl":"10.31083/AP38754","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38754"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Gut Microbiota in Two Different Maternal Exposure Models of Autism Spectrum Disorder in Mice.","authors":"Qiang Zhang, Xuying Pang, Min Guo, Yuezhu Wang, Yu Xu, Quan Li, Huajun Zheng","doi":"10.31083/AP38790","DOIUrl":"10.31083/AP38790","url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with unknown etiology and unclear pathogenesis. Although construction of animal models of ASD using chemical exposure during pregnancy is a mature technique, the gut microbiota of these exposure models induced using different chemicals in mice have not been compared.</p><p><strong>Methods: </strong>To compare the effects of exposure to different chemicals during pregnancy on the composition of gut microbiota in offspring, we treated Institute of Cancer Research (ICR) mice with lipopolysaccharide (LPS) and valproic acid (VPA) during pregnancy to construct different offspring ASD mouse models. After successful model construction, the gut microbiota of these models were studied.</p><p><strong>Results: </strong>After adjusting for the random effects of the litter, the two groups showed a significant reduction in social time (social deficits) and an increase in self-grooming behaviors (repetitive and stereotyped behaviors). Gut microbiota analysis revealed significant changes, mostly a decrease, in the abundance of four phyla, 52 genera, and 41 species in the two types of ASD models. Several different gut microbes could be related to the development of ASD.</p><p><strong>Conclusions: </strong>Chemicals exposure during pregnancy induces ASD-related behavioral abnormalities in offspring mice. Importantly, exposure to different chemicals during pregnancy produces varying degrees of effects on gut microbiota composition in offspring ASD models. This finding can provide a reference for studies on the etiology and pathogenesis of ASD.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38790"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurosyphilis Diagnosis and Treatment in Psychiatric Hospitals: A Retrospective Study.","authors":"Yajie Wang, Zhili Hu, Heping Zheng, Xiaolin Qin, Changchang Li, Hui Zhang, Lianhong Zheng, Wujian Ke","doi":"10.31083/AP38794","DOIUrl":"10.31083/AP38794","url":null,"abstract":"<p><strong>Background: </strong>Neurosyphilis, caused by <i>Treponema pallidum</i> invading the nervous system, can lead to severe neurological complications across all stages of syphilis. Misdiagnosis is common, exacerbated by overlapping psychiatric conditions and diagnostic limitations. This study aims to improve the understanding and management of neurosyphilis in psychiatric settings to enhance diagnostic accuracy and treatment efficacy.</p><p><strong>Methods: </strong>A retrospective study used data from the Chinese Case Report System (CCRS) spanning 2014-2018. Four municipal psychiatric hospitals in Guangdong were chosen based on syphilis rates and psychiatric patient volumes. Sociodemographic data, syphilis history, symptoms, diagnostic and treatment details, and laboratory results were reviewed. The Brief Psychiatric Rating Scale (BPRS) assessed psychopathology symptoms. Treatment efficacy was evaluated using BPRS scores before and after standard treatment. Diagnoses followed national guidelines, with statistical analyses performed using logistic regression and <i>t</i>-tests.</p><p><strong>Results: </strong>Out of 69,436 psychosis patients screened, 1588 were diagnosed with syphilis, with 262 (16.5%) of these cases identified as neurosyphilis. Syphilis prevalence mildly declined from 2.8% (2014) to 2.0% (2016), while neurosyphilis cases increased marginally from 0.34% (2014) to 0.39% (2018). Confirmatory Cerebrospinal Fluid (CSF) tests were conducted in only 30.2% of neurosyphilis cases. Standard therapy was administered to 66.8% of patients, with significantly better outcomes in confirmed cases (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Diagnosing and treating neurosyphilis in Guangdong's psychiatric hospitals remains challenging. Accurate diagnosis and standardized treatment protocols are essential to effectively manage both syphilis and associated mental health complications caused by neurosyphilis.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38794"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}