Alpha psychiatry最新文献

{"title":"FYN Tyrosine Kinase Gene Polymorphisms in Alcohol-Dependent Korean Patients.","authors":"Sung Young Huh, Sung-Gon Kim, Ji-Hoon Kim, Hyeon-Kyeong Kim, Yeon-Sue Kim","doi":"10.31083/AP38752","DOIUrl":"10.31083/AP38752","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use disorder (AUD) is a common disease with a high economic cost. The glutamate cell signaling pathway associated with alcohol has been reported to be one of the main pathologies of AUD. Previous studies have suggested that <i>FYN</i>, which is known to control NMDA glutamate receptor function through phosphorylation, might be associated with AUD.</p><p><strong>Method: </strong>The present study included 354 subjects in the alcohol-dependent group and 139 subjects in the control group. The alcohol-dependent group was recruited from five university hospitals and a psychiatric hospital, and the control group was recruited from people who visited the university hospital for routine medical checkups in Korea. <i>FYN</i> gene single nucleotide polymorphism (SNPs) were selected based on SNP databases and previous studies of the <i>FYN</i> gene. Ten SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism techniques.</p><p><strong>Results: </strong>GG genotypes and G allele frequencies of rs1058134 in male AUD patients were significantly lower than in controls (<i>p</i> = 0.003). AA genotypes and A allele frequencies of rs12191154 in female AUD patients were significantly lower than in controls (<i>p</i> < 0.001, <i>p</i> = 0.003). In female AUD patients, AA genotypes and A allele frequencies of rs9387025 were significantly higher than in controls (<i>p</i> = 0.003).</p><p><strong>Conclusion: </strong>These findings suggest that the <i>FYN</i> gene may be a candidate gene for AUD. This may help for the planning of further studies to determine the function of each SNP and the exact relationship between the <i>FYN</i> gene and AUD.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38752"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocircuitry and Neuroanatomy in Panic Disorder: A Systematic Review.","authors":"Peter Kyriakoulis, Clarissa Wijaya, Laiana Quagliato, Rafael C Freire, Antonio E Nardi","doi":"10.31083/AP38756","DOIUrl":"10.31083/AP38756","url":null,"abstract":"<p><strong>Background: </strong>This review updates our understanding of the neuroanatomical and neurocircuitry factors involved in panic disorder (PD). Many aspects remain undetermined.</p><p><strong>Methods: </strong>Clinical studies and a randomized controlled trial were identified via PubMed database and included in this review.</p><p><strong>Results: </strong>The search, following PRISMA guidelines, identified 13 human studies and 3 animal studies. Nine human studies compared brain activity and connectivity between regions in PD patients. Neural activity in the amygdala was highlighted in six studies. The hippocampus had higher activation in PD patients compared to those with social phobia, but generally showed less activity compared to healthy controls. The parahippocampal gyrus and thalamus exhibited greater activation in PD patients than healthy controls. Activity in the prefrontal cortices was also noted, particularly the ventromedial prefrontal cortex (vmPFC), ventrolateral prefrontal cortex (vlPFC), dorsomedial prefrontal cortex (dmPFC), and dorsolateral prefrontal cortex (dlPFC). Other regions involved included the dorsal midbrain, left brainstem (showing hyperactivation), S1, and right caudate, which showed increased activity in PD patients. The left intraparietal sulcus (IPS) exhibited hypoactivation in response to predictable cues compared to unpredictable or neutral cues within the default mode network (DMN). Three animal studies suggested that electrical and chemical activation of the dorsal periaqueductal gray (dPAG) in rats elicited fight-or-flight behaviors, providing a model for panic attacks.</p><p><strong>Conclusions: </strong>Neuroimaging studies suggest several key regions involved in PD pathophysiology, including the brainstem, amygdala, hippocampus, parahippocampal gyrus, thalamus, insula, and prefrontal and cingulate cortices. Hypersensitivity in the brainstem and amygdala plays a role in activating the fear network. Further prospective studies are needed to identify the neuroanatomical sites involved in PD and fear circuitry.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38756"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application of China's Proactive Health Management Model for Community-Dwelling Elderly in Mental Health.","authors":"Huang Lin, Shujuan Xiao, Jinguo Zhai, Chichen Zhang","doi":"10.31083/AP38787","DOIUrl":"10.31083/AP38787","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38787"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in the Association between Social Support and Major Depression: A Mediation Analysis with Interoception Mediator.","authors":"Yuqing Wu, Meichen Lu, Xiaohong Liu, Yifan Sun, Zhenhe Zhou, Hongliang Zhou","doi":"10.31083/AP38763","DOIUrl":"10.31083/AP38763","url":null,"abstract":"<p><strong>Background: </strong>Social support is recognized as a critical factor in both the prevention and management of Major depression Disorder (MDD), and can influence interoceptive processes. The mechanism of sex differences in the association between social support and MDD has not been clarified. This study was to elucidate the mechanism of sex differences in the association between social support and MDD by a mediation analysis with interoception mediator.</p><p><strong>Methods: </strong>Participants included 390 depressed patients (male/female: 150/240). Social Support Rating Scale (SSRS) was used to assess the degree of social support; Multidimensional Assessment of Interoceptive Awareness (MAIA-2C) was used to evaluate the interoception; Patient Health Questionnaire-9 (PHQ-9) was used to assess depression status. The pairwise correlated variables were put into the mediation model for the mediation analysis.</p><p><strong>Results: </strong>The depression status in female depressed patients was more severity than that in male depressed patients, while the social support in female depressed patients was less than that in male depressed patients. In male depressed patients, the Noticing of MAIA-2C plays a partial mediating role in social support and depression status, however, in female depressed patients, the Self-Regulation and Trusting of MAIA-2C plays a partial mediating role in social support and depression status.</p><p><strong>Conclusions: </strong>The female depressed patients receive significantly less social support than male counterparts, contributing to more severe symptoms, with the quality and adequacy of social support being crucial due to its mediation by interoception, highlighting a biological mechanism behind MDD. Differences in how interoception mediating role between genders suggest a physiological reason for the heightened severity of depressive symptoms in females.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38763"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Association between Diabetes Distress and Personality Traits: Insights from the Alternative DSM-5 Model for Personality Disorders.","authors":"Judita Konečná, David Lacko, Eva Horová, Karel D Riegel","doi":"10.31083/AP38760","DOIUrl":"10.31083/AP38760","url":null,"abstract":"<p><strong>Objective: </strong>Little is known about the association between subjectively experienced levels of diabetes distress (DD) and personality traits (PTs), even when levels of DD appear stable over time. This study aimed to use the Alternative Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Model for Personality Disorders (AMPD) to associate specific maladaptive PTs with experienced DD and to describe differences in the constellation of PTs between people with type 1 diabetes (PWT1D) and type 2 diabetes (PWT2D).</p><p><strong>Methods: </strong>A total of 358 participants with diabetes mellitus (DM) (56.2% female, mean age 42.33 years, standard deviation (SD) = 14.33) were evaluated using the Diabetes Distress Scale (DDS) and the shortened 160-item version of the Personality Inventory for DSM-5 (PID-5). Psychometric properties of the DDS were evaluated first, then the association between DDS and PID-5 scores, and the differences between groups based on diabetes type and DD level, were analyzed.</p><p><strong>Results: </strong>Strong associations were found between the PID-5 Negative Affectivity (NEF) domain and the emotional burden (β = 0.852, <i>p</i> _Holm < 0.001) and regimen distress (β = 0.435, <i>p</i> _Holm = 0.006) DDS subscale scores. PWT1D had a higher level of personality pathology than PWT2D, as did participants with elevated levels of DD across most domains and facets of PID-5.</p><p><strong>Conclusions: </strong>Our findings suggest that attention should be paid to the level of NEF among people with diabetes in relation to their emotional burden and perception of regimen distress. We recommend a distinction between people based on their diabetes type. Implications for clinical practice and interventions for DD perceived through the lens of the dimensional DSM-5 PT model are discussed.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38760"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Correlates of Depressive Symptoms and Cognitive Impairment in Elderly People over 65 Years Old in the Community and Nursing Homes.","authors":"Jie Zhang, Ying Zhang, Junjiao Ping, Jiali Luo, Haifeng Huang, Yanzhen Ren, Tingyun Jiang, Xinxia Liu","doi":"10.31083/AP38788","DOIUrl":"10.31083/AP38788","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive impairment and depression significantly reduce quality of life in the aging population. This study aimed to investigate the prevalence of depressive symptoms and cognitive impairment and explore its relationship in the elderly.</p><p><strong>Methods: </strong>A total of 1645 elderly people in nursing homes and 4703 elderly people in the community were enrolled in the survey. The Patient Health Questionnaire-9 and Ascertain Dementia-8 were employed to evaluate depressive symptoms and cognitive impairment.</p><p><strong>Results: </strong>The overall prevalence of cognitive impairment was 12.5% in the community-dwelling group and 52.2% in the nursing home group. The prevalence of cognitive impairment in nursing homes was significantly higher than that in community-dwelling groups for the same age group (<i>p</i> < 0.001). The overall prevalence of depressive symptoms was 3.9% in the community-dwelling group and 2.0% in the nursing home group. The prevalence of depressive symptoms increased with age in the community-dwelling group (<i>p</i> < 0.001). The binary logistic regression results showed that the type of care mode affected the prevalence of cognitive impairment, and the elderly in nursing homes had a high risk of cognitive impairment (odds ratio [OR] = 3.528, 95% confidence interval [CI]: 2.209-5.635, <i>p</i> < 0.001); depressive symptoms had a significant positive correlation with the odds of cognitive impairment (OR = 1.854, 95% CI: 1.052-3.266, <i>p</i> < 0.05); and the cognitive impairment rate increased with age (OR = 1.412, 95% CI: 1.044-1.910, <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>There was an increased prevalence in cognitive impairment as well as depressive symptoms in the aging population in Zhongshan city. Population-based mental health strategies need to be urgently implemented for the aging.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38788"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive Negative Thinking is Associated With Depression and Feeding Status at 3 and 6 Months Postpartum: Retrospective Study.","authors":"Chunfeng Xing, Guoxin Li, Guangqing Zhang, Yaxin Liu, Meirong Yan, Guilin Liu","doi":"10.31083/AP38795","DOIUrl":"10.31083/AP38795","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between repetitive negative thinking and depression as well as feeding status at 3 and 6 months postpartum.</p><p><strong>Method: </strong>One hundred and twenty-eight pregnant women recruited by the hospital from January 2020 to June 2022 were selected for the study. General demographic data of pregnant women, the multiple Persistent Thinking Questionnaire (PTQ), the Edinburgh Postnatal Depression Scale (EPDS) at 3 and 6 months postpartum, and breastfeeding status were collected. According to PTQ scores, the pregnant women were divided into high subgroup (scores ≥30) and low subgroup (scores <30). Intergroup comparisons of continuous variables following a normal distribution were performed using the <i>t</i>-test, while categorical data were analyzed using the χ² test. Spearman correlation analysis was conducted to examine the relationship between PTQ, EPDS, and breastfeeding status.</p><p><strong>Results: </strong>EPDS scores were higher in the high group than in the low group at 3 and 6 months postpartum (<i>p</i> < 0.001). The breastfeeding rates in the high group were lower than that in the low group at 3 and 6 months postpartum (<i>p</i> < 0.001). Higher PTQ scores were associated with postpartum depression at 3 and 6 months (r = 0.379, <i>p</i> < 0.001; r = 0.358, <i>p</i> < 0.001) and lower breastfeeding rates (r = -0.346, <i>p</i> < 0.001; r = -0.353, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Higher PTQ scores are associated with increased postpartum depression and reduced breastfeeding rates at 3 and 6 months postpartum, suggesting that repetitive negative thinking may be related to postpartum mental health and feeding outcomes.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38795"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Children's Dietary Inflammatory Index with Depression and Anxiety Symptoms in Adolescents: Mediating Role of Inflammation and Cardiometabolic Risk Factors.","authors":"Kezban Şahin, Hülya Yardımcı, Murat Açık, Alkım Öden Akman, Fadime Yüksel","doi":"10.31083/AP38791","DOIUrl":"10.31083/AP38791","url":null,"abstract":"<p><strong>Background: </strong>Evidence is scarce on the mechanisms involved in the relationship between dietary inflammatory index and mental health in adolescents. This study aimed to assess the association between children-DII (C-DII) and depressive and anxiety disorder symptoms in adolescents and to explore whether inflammation and cardiometabolic risk factors mediate this association.</p><p><strong>Methods: </strong>The study was conducted at the Ankara City Hospital Pediatrics Polyclinic and 304 adolescents. In cross-sectional study, adolescents were asked general information questions. Anthropometric measurements were performed and some biochemical parameters and inflammation (C-reactive protein (CRP)) were obtained. The C-DII score was calculated from 24-h dietary recalls. Depression and anxiety levels of the participants were assessed by self-report. Structural equation modelling analyzed how cardiometabolic risk factors and inflammation mediate the relationship between mental health and dietary inflammation.</p><p><strong>Results: </strong>C-DII scores were positively associated with depression and anxiety score (β [95% confidence interval (CI)] = 0.224 [0.08-0.25] for depression; 0.923 [0.04-1.67] for anxiety). Except for dietary inflammation with anxiety in girls, these relationships remained statistically significant in all subgroups by sex. It was determined that CRP partially mediated the relationship between dietary inflammation and depression and anxiety. It was determined that body mass index (BMI)-z score and waist circumference (WC) mediated the relationship between dietary inflammation and depression scores.</p><p><strong>Conclusions: </strong>Our findings indicate that the higher pro-inflammatory potential of diet is associated with a higher risk of depression and anxiety, and this association may be mediated by CRP for depression and anxiety, WC, and BMI-z score for only depression. Further research is required to verify our findings and clarify the latent mechanism in larger populations.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38791"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Paliperidone Combined with Sertraline in the Treatment of Schizophrenia and its Influence on Serum Neurofunctional Related Factors.","authors":"Meng Gu, Zhilian Pi, Long Zhu, Jun Zhang","doi":"10.31083/AP38775","DOIUrl":"10.31083/AP38775","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the efficacy of paliperidone combined with sertraline in treating schizophrenia (SCZ) and its effect on serum neurofunctional factors.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on SCZ patients admitted between June 2020 and June 2021. Initially, 80 patients were treated with paliperidone, while 36 received a combination of paliperidone and sertraline. Propensity score matching based on 3 covariates resulted in 2 groups: the control group (paliperidone alone, n = 36) and the observation group (paliperidone + sertraline, n = 36). The clinical efficacy, adverse reactions, quality of life scores, serum biomarkers levels related to nerve and liver function, and anxiety and depression levels were compared between the 2 groups.</p><p><strong>Results: </strong>The observation group demonstrated higher total effectiveness than the control group (<i>p</i> = 0.011). Post-treatment, the scores of all dimensions of quality of life in both groups were improved, and the observation group was higher than the control group (<i>p</i> < 0.001). Post-treatment, the observation group exhibited lower neuron-specific enolase (NSE) and higher neuregulin 1 (NRG1) levels than the control group (<i>p</i> < 0.001). The levels of aminotransferase (AST), total bilirubin (TBiL) and alanine aminotransferase (ALT) increased in both groups post-treatment (<i>p</i> < 0.001). The levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-2 (IL-2) decreased in both groups post-treatment, and the observation group had lower levels of these cytokines compared to the control group after treatment (<i>p</i> < 0.001). Post-treatment, Hamilton Anxiety Scale (HAMA) score and Hamilton Depression Scale (HAMD) score decreased in both groups, with the observation group showing lower scores than the control group (<i>p</i> < 0.001). The changes in the scores of various dimensions of quality of life, HAMA and HAMD scores, neurofunctional factors and inflammatory markers levels in the observation group were greater than those in the control group (<i>p</i> < 0.001). There were no serious side effects during and after treatment in both groups.</p><p><strong>Conclusions: </strong>Paliperidone combined with sertraline effectively improves serum neuregulin levels in SCZ patients, alleviates negative emotional effects without causing liver or kidney damage, and demonstrates excellent clinical efficacy and safety.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38775"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-Analysis of the Clinical Efficacy of Auricular Acupressure on Patients with Depression.","authors":"Xiaohua Yang, Qingqing Liu, Xiaoping Wu","doi":"10.31083/AP38776","DOIUrl":"10.31083/AP38776","url":null,"abstract":"<p><strong>Objective: </strong>A systematic review of evaluating the clinical effects of auricular acupressure on patients with depression.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in various electronic databases including PubMed, Web of Science, Cochrane Library, Google Scholar, CNKI, Wanfang, Embase, and VIP. The search time limit was from the establishment of the database to December, 2023. The included results were integrated and analyzed, and ReviewManager 5.4 was used for meta-analysis.</p><p><strong>Results: </strong>A total of 13 studies with a total of 504 depression patients were included. Compared with the control group, auricular acupressure showed a significant reduction in depression scores, as reflected in the Hamilton Depression Scale (standardized mean difference [SMD] = -1.50, 95% confidence interval [CI]: -2.25~-0.75); risk rate [RR] = 1.96, 95% CI: 0.66~5.82), Self-Rating Depression Scale (SMD = -0.91, 95% CI: -1.15~-0.67), and Patient Health Questionnaire scores (SMD = -0.94, 95% CI: -1.46~-0.41; all <i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>The meta-analysis suggested that auricular acupoint therapy is safe and effective in treating depression, and can reduce Hamilton Depression Scale (HAMD) and Pittsburgh Sleep Quality Index (PSQI) scores. There were no obvious adverse reactions. This therapy could therefore be used as a complementary therapeutic approach for patients with depression.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 1","pages":"38776"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}