Alpha psychiatry最新文献

{"title":"Adaptation to Preceding Acute Psychological Stress is Associated With Subsequent Stress Coping Levels via Corticoid Receptors.","authors":"Yuta Aoto, Emi Kasama, Tohru Matsuki, Kenjiro Seki","doi":"10.31083/AP46061","DOIUrl":"10.31083/AP46061","url":null,"abstract":"<p><strong>Objective: </strong>Hypothalamic‒pituitary‒adrenal axis response is essential for coping with acute stressors, while maladaptive stress coping may increase the risk of major depressive disorder. We previously demonstrated that behavioral patterns induced by prior psychological stress predict coping levels in response to future stressors. This study investigated whether activating corticotropin-releasing hormone (CRH) and corticosteroid receptors mediates psychological stress-induced coping behavior.</p><p><strong>Methods: </strong>Behavioral responses in mice exhibiting a fear response elicited by exposure to 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), a synthetic component of fox feces, as preceding psychological stress, were assessed by measuring central zone entries in an open-field test. Time spent immobile during the tail suspension test was evaluated as a subsequent aversive stress-coping level. CRH overexpression was induced by adeno-associated virus injection (Hypo-CRH-OE) into the paraventricular hypothalamic nucleus. Dexamethasone (10 μg/kg, s.c.), a glucocorticoid receptor agonist, or fludrocortisone (5 mg/kg, s.c.), a mineralocorticoid receptor agonist was administered 30 min before behavioral tests.</p><p><strong>Results: </strong>Hypo-CRH-OE mice exhibited significantly higher plasma corticosterone levels than controls, without changes in baseline of locomotor activity or innate fear sensitivity. During TMT exposure, Hypo-CRH-OE mice showed lower central activity in the open-field test, accompanied by longer immobility time in the tail suspension test (TST), disrupting the correlation between these behaviors. A similar disruptive effect was observed in fludrocortisone-treated mice but not in dexamethasone-treated mice. Additionally, fludrocortisone, but not dexamethasone, prolonged immobility during the TST.</p><p><strong>Conclusions: </strong>Preceding psychological stress-induced behavioral patterns may predict coping levels through mineralocorticoid receptor activations offering a potential target for improving stress resilience and preventing depression.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"46061"},"PeriodicalIF":3.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NHANES 2011-2014: Association Between Conicity Index and Cognitive Performance in Older Adults.","authors":"Fei Chen, Ken Chen","doi":"10.31083/AP46031","DOIUrl":"10.31083/AP46031","url":null,"abstract":"<p><strong>Background: </strong>The negative impact of obesity on cognitive function (CF) is well-established; nevertheless, no prior studies have explored the link between conicity index and cognitive performance. This research sought to investigate the link between conicity index and cognitive impairment.</p><p><strong>Methods: </strong>Data were obtained from a cross-sectional analysis of the National Health and Nutrition Examination Survey 2011-2014 (NHANES), with CF evaluated by the total scores of three cognitive tests (TCT), the delayed recall test (DRT), the immediate recall test (IRT), the animal fluency test (AFT), and the digit symbol substitution test (DSST). The conicity index was derived from waist circumference, height, and weight. Multiple linear regression, smooth curve fitting, and subgroup interaction analyses were utilized to explore the correlation between conicity index and cognitive performance.</p><p><strong>Results: </strong>The study included 2752 subjects and the results indicated that increasing conicity index was markedly associated with declining CF. In fully adjusted models, the conicity index was linked to reductions in total cognitive score (β = -16.35, 95% confidence interval (CI): -26.68 to -6.02, <i>p</i> = 0.0019) and DRT (β = -1.52, 95% CI: -2.74 to -0.30, <i>p</i> = 0.0151), IRT (β = -2.93, 95% CI: -5.37 to -0.48, <i>p</i> = 0.0190), AFT (β = -2.03, 95% CI: -4.88 to 0.82, <i>p</i> = 0.1636), and DSST (β = -9.88, 95% CI: -17.11 to -2.65, <i>p</i> = 0.0075) scores. However, the negative association between conicity index and AFT score was not statistically significant.</p><p><strong>Conclusions: </strong>Lower CF is associated with a higher conicity index. The conicity index is useful for the early detection of cognitive decline.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"46031"},"PeriodicalIF":3.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindful Attention Awareness and Residual Mood and Anxiety Symptoms in Remitted Patients With Bipolar I Disorder.","authors":"Selin Alkan, Habib Erensoy, Tonguc Demir Berkol","doi":"10.31083/AP46029","DOIUrl":"10.31083/AP46029","url":null,"abstract":"<p><strong>Objective: </strong>In bipolar disorder, residual mood symptoms often persist even during the euthymic period, impairing functionality in 30-60% of patients in clinical remission. Addressing residual symptoms is critical as they are linked to reduced functionality and subjective wellbeing. This cross-sectional study aimed to determine the relationship between mindful attention awareness (MASS) and residual symptom severity in bipolar I disorder.</p><p><strong>Methods: </strong>This study included 100 patients with bipolar I disorder (BD-I) in remission, recruited consecutively from outpatient clinics between December, 2019 and March, 2020. The patients were evaluated using the sociodemographic data form, Hamilton Depression Rating Scale (HAM-D), Young Mania Rating Scale (YMRS), and Mindful Attention Awareness Scale (MAAS).</p><p><strong>Results: </strong>As the MAAS of the patients increases, their depressive symptoms decrease (<i>p</i> < 0.001). As the MAAS of the patients increases, their anxiety symptoms decrease (<i>p</i> < 0.001). No statistically significant relationship was found between the mindful attention awareness of the patients and their manic symptoms (<i>p</i> = 0.161). Two variables (HAM-D and Hamilton Anxiety Rating Scale Scores (HAM-A)) in the multiple linear regression model explain 21.8% of the change in MAAS score.</p><p><strong>Conclusion: </strong>Residual depressive and anxiety symptoms are predictive of lower MAAS in bipolar I disorder. Incorporating strategies to manage residual mood symptoms and improve mindfulness may enhance functionality and facilitate complete remission. However, given the cross-sectional design and the lack of a control group, causal inferences cannot be made. Further longitudinal and interventional studies are needed to explore the efficacy of mindfulness-based approaches in BD-I and determine whether the observed associations are specific to this disorder.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"46029"},"PeriodicalIF":3.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of PTSD on Problematic Internet Use among Chinese Earthquake Survivors: The Mediating Role of Fear of Missing Out and Rumination.","authors":"Chen Gong, Yezi Li","doi":"10.31083/AP46030","DOIUrl":"10.31083/AP46030","url":null,"abstract":"<p><strong>Objective: </strong>Problematic internet use (PIU) is a general behavioral addiction and encompasses various syndromes. Previous research found that traumatic events may potentially influence or alter the propensity for PIU. This study aimed to explore the mediating role of fear of missing out (FOMO) and rumination in the influence of post-traumatic stress disorder (PTSD) on PIU among Wenchuan earthquake survivors.</p><p><strong>Methods: </strong>In the fall of 2023, 665 valid participants' responses were selected in this cross-sectional study. The PTSD Checklist (PCL-C), FOMO Scale, Rumination Scale (RRS), and Generalized Problematic Internet Use Scale 2 (GPIUS2) were used to measure participants' internet usage and mental state. Description analysis and structural equation model analysis were examined by using SmartPLS.</p><p><strong>Results: </strong>PTSD positively influenced FOMO (β = 0.315, <i>p</i> < 0.001), rumination (β = 0.279, <i>p</i> = 0.001), and PIU (β = 0.213, <i>p</i> < 0.001). FOMO (β = 0.08, 95% CI (confidence interval) [0.037, 0.144], <i>p</i> = 0.005) and rumination (β = 0.093, 95% CI [0.032, 0.139], <i>p</i> = 0.002) played a mediating role in the influence of PTSD on PIU. Regarding the relationship between PTSD and PIU, direct and indirect effects comprised 45.6% and 54.4%. PTSD had a positively significant effect on PIU by mediating FOMO and rumination to form a chain mediation model (β = 0.081, 95% CI [0.010, 0.039], <i>p</i> = 0.002).</p><p><strong>Conclusions: </strong>This study investigated online usage and media psychology among survivors of the Wenchuan earthquake in China. FOMO and rumination were found to be important factors influencing the relationship between PTSD and PIU. To prevent or relieve people's PIU, we propose that medical practitioners and local government intervene on FOMO through effective measures to decrease rumination. The individual differences and specific internet platform usage that influence these psychological variables should also be further investigated in future studies.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"46030"},"PeriodicalIF":3.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Obesity and Depressive Symptoms: Mediation by C-Reactive Protein and Neutrophil-to-Lymphocyte Ratio.","authors":"Pu-Le Liu, Yan Zhang, Jiao Li, Jing Du, Ning Yang, Qiang-Li Dong","doi":"10.31083/AP45975","DOIUrl":"10.31083/AP45975","url":null,"abstract":"<p><strong>Background: </strong>Obesity and depressive disorders are significant public health concerns, and their association is well-documented. This study investigates the role of inflammatory markers, specifically C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), in mediating the relationship between obesity and depressive symptoms.</p><p><strong>Methods: </strong>We utilized data from 37,538 adults from the National Health and Nutrition Examination Survey (NHANES), covering the period from 2005 to March, 2020, pre-pandemic. Depressive symptoms were measured using the Patient Health Questionnaire-9 (PHQ-9), while inflammatory markers were assessed via NLR and CRP levels.</p><p><strong>Results: </strong>Results indicated a positive correlation between obesity, NLR, and CRP levels, and depressive symptoms. Notably, CRP exhibited a significant mediating effect in the obesity and depressive symptoms link, whereas NLR did not. (NLR: 0.0926%, <i>p</i> = 0.740; CRP: 32%, <i>p</i> < 0.001). Furthermore, the mediating effect of CRP in the male group was significantly higher than in the female group (Men: 57%, <i>p</i> < 0.001; Women: 16%, <i>p</i> = 0.046).</p><p><strong>Conclusion: </strong>These findings provide new insights into the mechanisms linking obesity and depressive symptoms, especially in men, and may guide future therapeutic strategies.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"45975"},"PeriodicalIF":3.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Research on Fear of Dementia Through eHealth Solutions in an Aging Society.","authors":"Huohuo Dai, Jiska J Aardoom, Niels H Chavannes, Anke Versluis","doi":"10.31083/AP45974","DOIUrl":"10.31083/AP45974","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"45974"},"PeriodicalIF":3.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Configurations of Family Risk Factors and Mental Health Symptoms Among Grade 4-6 Children in Guangdong, China: A Large-Scale Crisp-Set Qualitative Comparative Analysis Based on a Cumulative Risk Model.","authors":"Kaifeng Liu, En Fu, Ziyi Deng, Minrui Zhang, Yongxing Guo, Qiufeng Gao, Ruixiang Gao, Lei Mo","doi":"10.31083/AP45872","DOIUrl":"10.31083/AP45872","url":null,"abstract":"<p><strong>Background: </strong>Children's mental health is significantly influenced by family environments, where multiple risks often coexist, exert unequal impacts, and combine in different configurations that can result in diverse developmental outcomes. This study examines how different configurations of cumulative family risks influence mental health symptoms in Chinese children using a novel person-centered approach.</p><p><strong>Materials and methods: </strong>Data were collected through a large-scale, semester-based comprehensive survey of 34,041 children in Grades 4 to 6 in an economically underdeveloped county-level city in Guangdong, China, during November and December, 2022. Six family risk indicators were examined: incomplete family structure, parent-child separation, financial hardship, low parental education, lack of family intimacy, and family conflict. The Pediatric Symptom Checklist was used to measure children's mental health outcomes, consisting of internalizing problems, externalizing problems, and attention problems. Crisp-set qualitative comparative analysis was applied to identify specific configurations of family risks associated with different mental health outcomes.</p><p><strong>Results: </strong>No single risk factor was found necessary or sufficient to explain mental health outcomes; configurations of multiple risks were more predictive. Externalizing and attention symptoms shared one configuration, which also contributed to internalizing symptoms. Additionally, three distinct configurations were uniquely associated with internalizing symptoms. Only lack of family intimacy and family conflict consistently appeared as detrimental across all configurations.</p><p><strong>Conclusions: </strong>This study reinforces the cumulative risk model and aligns with the concepts of multifinality and equifinality. It emphasizes the importance of monitoring children with coexisting risks and targeted interventions addressing one or two key factors rather than all factors simultaneously. Future research should adopt longitudinal designs and include broader factors.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"45872"},"PeriodicalIF":3.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in Molecular Mechanisms of Depression Induced by Mother-Infant Separation and Intervention of Traditional Chinese Medicine.","authors":"Ling-Hui Kong, Min Liu, Hui Li, Rui-Rui Shang, Shi-Meng Lv, Zhong-Lin Wang, Qiang Ren","doi":"10.31083/AP45684","DOIUrl":"10.31083/AP45684","url":null,"abstract":"<p><p>Depression is a serious mental and emotional disorder and is considered to be the greatest cause of non-fatal disease worldwide. Early life stress (ELS) refers to the exposure of an individual to physical and psychological stress events such as neglect or abuse in early life that has a long-term impact on brain development, thus inducing emotional and cognitive disorders in adulthood. It is the main susceptibility and risk factor for depression. Current clinical treatment is primarily based on Western medicines such as fluoxetine, but there can be serious adverse reactions. Therefore, exploring the biochemical mechanism of ELS-induced disorders and how to intervene effectively and safely to prevent and treat depression has become a significant issue. Traditional Chinese medicine (TCM) has the unique advantages of few adverse reactions and high safety and has great potential for the treatment of depression. Maternal separation (MS) is one of the most important and commonly used models for simulating ELS. Many studies have shown that MS-induced depression involves the regulation of multiple pathways and several studies have shown that TCM improves MS-induced depression. However, there is currently a lack of systematic reviews and summaries of the molecular mechanisms of MS-induced depression and traditional Chinese medical interventions. Therefore, the mechanisms of action and traditional Chinese medical interventions for MS-mediated depression were reviewed by searching recent relevant literature and discussing the limitations of current research. The aim was to provide guidance for follow-up basic research and clinical treatment.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"45684"},"PeriodicalIF":3.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive Symptoms and Their Association With Quality of Life in Older Adults With Cataracts: A National Survey in China.","authors":"Zi-Mu Chen, Meng-Yi Chen, Qinge Zhang, Yuan Feng, Zhaohui Su, Teris Cheung, Gang Wang, Chee H Ng, Yu-Tao Xiang","doi":"10.31083/AP45683","DOIUrl":"10.31083/AP45683","url":null,"abstract":"<p><strong>Background: </strong>Depression is common among older adults with cataracts and is associated with significant functional impairment. However, the complex interrelationships among different depression symptoms are often overlooked by conventional mood disorders research based on total scores of depression measures. This study examined the interrelationships between different depressive symptoms and quality of life (QoL) in older adults with cataracts based on a national survey. By analyzing the key depressive symptoms related to QoL in this vulnerable population, the study aimed to identify potential critical treatment targets.</p><p><strong>Methods: </strong>In this study, the 10-item Center for Epidemiologic Studies Short Depression Scale and the World Health Organization Quality of Life-brief version were used to measure depressive symptoms and QoL respectively. In the network analysis, Expected Influence was used to identify the central symptoms, and a flow network model was used to examine the symptoms that directly affected QoL.</p><p><strong>Results: </strong>A total of 1683 participants were included in the analysis. Economic status was the only identified risk factor for depression in older adults with cataracts. The most central symptoms in the depression network were \"Feeling blue\", \"Everything was an effort\", and \"Inability to get going\". The flow network indicated that QoL had the strongest direct connections with \"Unhappiness\", \"Sleep disturbances\" and \"Feeling blue\".</p><p><strong>Conclusions: </strong>Depression was found to be common among older adults with cataracts. To mitigate the negative impact of depression on QoL, psychosocial interventions targeting the most central symptoms and those directly related to QoL should be prioritized.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"45683"},"PeriodicalIF":3.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Mechanism of Antidepressant Effects of Active Ingredients in Traditional Chinese Medicine: The Role of Autophagy.","authors":"Li-Juan Zhang, Dan Chen, Kai-Yong Xu, Rui-Rui Shang, Xiao-Yu Liu, Zi-Fa Li, Kang-Feng Wang, Min Zhang","doi":"10.31083/AP45685","DOIUrl":"10.31083/AP45685","url":null,"abstract":"<p><p>In clinical practice, selective serotonin reuptake inhibitors (SSRIs), a kind of Western medicine, are the primary treatment for depression, a complex mental illness. However, these treatments are associated with significant adverse reactions. With their many benefits and distinctive features, such as all-encompassing intervention and general control through several targets, processes, and pathways, the active components in traditional Chinese medicine (TCM) hold great promise for the treatment of depression. Autophagy plays a crucial role in the pathophysiology of depression, and its regulation has emerged as a potentially crucial management tactic. However, comprehensive evaluations of the link between depression and mitochondrial autophagy, as well as the therapeutic potential of TCM's active components, remain limited. This review examined recent literature on autophagy and its role in depression, along with studies on the effects of TCM active ingredients. Furthermore, it highlighted the limitations of current research to offer insights to guide future fundamental studies and clinical treatments for depression.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"45685"},"PeriodicalIF":3.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}