Alpha psychiatry最新文献

{"title":"Are Pollution and Climate Change Potential Factors in the Development of Obsessive-Compulsive Disorder?","authors":"Luigi Attademo","doi":"10.31083/AP39005","DOIUrl":"10.31083/AP39005","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"39005"},"PeriodicalIF":3.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Postictal Delirium in Geriatric Patients Undergoing Electroconvulsive Therapy: The Role of Lithium and Quetiapine.","authors":"Shiling Wu, Kun Li, Jiang Long, Chenchen Zhang, Rui Li, Bochao Cheng, Minne Cao, Wei Deng","doi":"10.31083/AP45431","DOIUrl":"10.31083/AP45431","url":null,"abstract":"<p><strong>Background: </strong>Postictal delirium (PID) is a significant and often underrecognized adverse effect associated with electroconvulsive therapy (ECT) in geriatric patients. Despite its clinical relevance, the specific risk factors contributing to the development of PID in this vulnerable population remain inadequately understood, which may affect treatment outcomes and patient safety.</p><p><strong>Methods: </strong>In this retrospective study, we analyzed data from 168 elderly patients who underwent ECT between 2009 and 2020 at a general hospital in China. Univariate analyses of sociodemographic and clinical characteristics were performed to identify variables for inclusion in a logistic regression model. Multiple binary logistic regression analysis was performed to determine the relationship between these variables and PID occurrence.</p><p><strong>Results: </strong>The incidence of PID was 20.8% (35/168) among the study cohort. Univariate analysis revealed statistically significant differences between PID and non-PID groups for lithium (<i>χ</i> ² = 6.67, <i>p</i> <i>=</i> 0.010), quetiapine (<i>χ</i> ² = 4.36, <i>p</i> = 0.037), number of ECT sessions (<i>U</i> = 3065.50, <i>p</i> = 0.003), and response rate (<i>χ</i> ² = 12.86, <i>p <</i> 0.001). Logistic regression analysis demonstrated that lithium (odds ratio (OR) = 5.128; <i>p</i> = 0.009) and quetiapine (OR = 2.562; <i>p</i> = 0.024) were significantly associated with PID.</p><p><strong>Conclusion: </strong>Our findings indicate that lithium and quetiapine use significantly increase the risk of developing PID, underscoring the need for clinical vigilance. Careful consideration of these medications when planning ECT treatment is recommended to minimize the risk of postictal complications and optimize therapeutic outcomes.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"45431"},"PeriodicalIF":3.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Childhood Abuse, Personality, and Depression: A Narrative Review.","authors":"Wei Luo, Bao-Liang Zhong","doi":"10.31083/AP45405","DOIUrl":"10.31083/AP45405","url":null,"abstract":"<p><p>Depression is a common mental health problem that imposes a significant burden on both individuals and society. Numerous studies have shown that childhood abuse has a long-lasting detrimental effect on mental health, including the development of depression. This study reviews recent studies on the association between childhood abuse and depression, highlighting the robust causal link between childhood abuse and subsequent depression. The strength of this association varies depending on the type of abuse, with emotional abuse showing a particularly strong connection to depression. In addition, this narrative review examines the role of personality in the relationship between childhood abuse and depression. Evidence indicates that personality traits act as both mediators and moderators in this association, with neuroticism being particularly influential. Although available research evidence primarily consists of cross-sectional studies, which cannot determine the temporal sequence of childhood abuse, personality problems, and depression, the interrelations of these three variables provide a more comprehensive understanding of the etiology of depression. These insights lay the foundation for future longitudinal research and inform the development of more targeted preventive and therapeutic interventions in clinical psychiatry.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"45405"},"PeriodicalIF":3.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence for Management of Major Depression: Initial Design, Progress, and Research Plans.","authors":"Farrokh Alemi, Janusz Wojtusiak, Aneel Ursani, K Pierre Eklou, Kevin Lybarger","doi":"10.31083/AP44608","DOIUrl":"10.31083/AP44608","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Herein, we report on the initial development, progress, and future plans for an autonomous artificial intelligence (AI) system designed to manage major depressive disorder (MDD). The system is a web-based, patient-facing conversational AI that collects medical history, provides presumed diagnosis, recommends treatment, and coordinates care for patients with MDD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The system includes seven components, five of which are complete and two are in development. The first component is the AI's knowledgebase, which was constructed using Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression to analyze extensive patient medical histories and identify factors influencing response to antidepressants. The second component is a series of adjustments to the knowledgebase designed to correct algorithm bias in patient subgroups. The third component is a conversational Large Language Model (LLM) that efficiently gathers patients' medical histories. The fourth component is a dialogue management system that minimizes digressions in the LLM conversations, using a topic network statistically derived from the AI's own knowledgebase. The fifth component is planned to enable real-time, human-in-the-loop monitoring. The sixth component is an existing analytical, non-generative module that provides and explains treatment advice. The seventh component is planned to coordinate care with clinicians via closed-loop referrals.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In component 1, the AI's knowledgebase correctly predicted 69.2% to 78.5% of the variation in response to 15 oral antidepressants. Patients treated by AI-concordant clinicians were 17.5% more likely to benefit from their treatment than patients of AI-discordant clinicians. In component 2, the use of the system required adjustments to improve accuracy for predicting the responses of African Americans to four antidepressants and no adjustments were required for the remaining 10 antidepressants. In component 3, the conversational intake efficiently covered 1499 relevant medical history events (including 700 diagnoses, 550 medications, 151 procedures, and 98 prior antidepressant responses). In the fourth component, the dialogue management system was effective in maintaining a long dialogue with many turns in the conversation. In the sixth component, the advice system was able to rely exclusively on pre-set text. An online ad campaign attracted 1536 residents of Virginia to use the advice system. Initially, a focus group of clinicians was skeptical of the value of the advice system and requested more prospective studies before they would implement the system in their clinics. When the system was redesigned to advise patients at home, clinicians were willing to receive referrals from the system and discuss the advice of the system with their patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Further research is needed to refine and evaluate the system.","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"44608"},"PeriodicalIF":3.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Love Attitudes, Attachment Styles, and Personality Traits in Women Who Have Experienced Domestic Violence.","authors":"Selin Balki Tekin, Ayşe Nur İnci Kenar, Hande Şenol","doi":"10.31083/AP44607","DOIUrl":"10.31083/AP44607","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the relationship between attitudes toward love, attachment styles, and personality traits in women who have experienced domestic violence (DV).</p><p><strong>Methods: </strong>The study consisted of 64 women who experienced DV and 64 women without such history. All participants completed a sociodemographic data form and three assessment scales.</p><p><strong>Results: </strong>Among women who were exposed to violence, attitudes toward altruistic and passionate love were significantly higher (<i>p</i> < 0.001, <i>p</i> = 0.026). In contrast, women who had not experienced violence showed higher levels of friendly and possessive love attitudes (<i>p</i> = 0.010, <i>p</i> < 0.001). Women who experienced violence also exhibited a significant increase in both anxious and avoidant attachment styles (<i>p</i> < 0.001 and <i>p</i> < 0.001), while the emotionally balanced personality trait was significantly lower (<i>p</i> = 0.006). Additionally, positive correlations were found between altruistic love and anxious attachment style and between logical love and anxious attachment style (<i>p</i> = 0.021, r = 0.288; <i>p</i> = 0.033, r = 0.267, respectively). Conversely, negative correlations were observed between altruistic love attitudes and both extraversion and emotional stability (<i>p</i> = 0.038, r = -0.261; <i>p</i> = 0.030, r = -0.271, respectively), between game-playing love attitude and conscientiousness and emotional stability (<i>p</i> = 0.046, r = -0.250; <i>p</i> = 0.027, r = -0.277, respectively), and between passionate love attitude and emotional stability (<i>p</i> = 0.009, r = -0.323). Furthermore, a positive correlation was noted between friendly love attitudes and agreeableness (<i>p</i> = 0.017, r = 0.296).</p><p><strong>Conclusions: </strong>Individuals with high levels of emotional stability, along with friendly and possessive love attitudes, may be better equipped to cope with violence, while those with anxious and avoidant attachment styles, as well as altruistic and passionate love attitudes, may have difficulty handling such experiences.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 4","pages":"44607"},"PeriodicalIF":3.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Intermittent Fasting on Anxiety and the Functional Connectivity of the Amygdala in Healthy Adults.","authors":"Lijuan Huo, Yibo Li, Yu Fu, Zhi Yang, Lijun Jia, Chunbo Li, Bin Zhang","doi":"10.31083/AP44384","DOIUrl":"10.31083/AP44384","url":null,"abstract":"<p><strong>Objectives: </strong>This study assessed the effect of intermittent fasting on anxiety, depression, and connectivity of the amygdala by functional magnetic resonance imaging in healthy adults. The findings could provide insights into IF as a potential non-pharmacological intervention for anxiety, offering clinical significance as a cost-effective and accessible alternative or adjunct therapy.</p><p><strong>Methods: </strong>Twenty-six healthy adults followed a time-restricted eating regimen for 50 days, fasting for 18 hours daily. Assessments were conducted at baseline, during fasting (days 10, 30, and 50), and after fasting (days 20 and ~60). Measurements included body mass index (BMI), metabolic parameters, Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), and resting-state functional magnetic resonance imaging (fMRI) connectivity of the amygdala.</p><p><strong>Results: </strong>The BMI, glucose and insulin concentrations, insulin resistance, and anxiety scores significantly decreased during and after fasting compared to the baseline measurements (all <i>p</i> < 0.05), lasting for two months. Furthermore, we used the bilateral laterobasal amygdala as seed regions, which are responsible for emotional regulation and anxiety-like behaviours; we found changes in resting-state connectivity with the postcentral gyrus on fasting days 30 and 50.</p><p><strong>Conclusion: </strong>IF reduces anxiety by modulating amygdala functional connectivity and enhancing brain plasticity, suggesting its potential as a therapeutic approach for anxiety and related emotional disorders. The findings underscore IF's promise as an alternative or adjuvant intervention in psychiatric care.</p><p><strong>Clinical trial registration: </strong>The study was registered at Clinicaltrials.gov (https://www.chictr.org.cn/showproj.html?proj=136213), registration number: ChiCTR2100052473.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"44384"},"PeriodicalIF":1.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Exposome of Mental Health Outcomes to Enhance Population Salutogenesis.","authors":"Melike Karaçam Doğan, Sinan Guloksuz","doi":"10.31083/AP44314","DOIUrl":"10.31083/AP44314","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"44314"},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Injection Start Regimen of Long-Acting Injectable Aripiprazole: Retrospective Data From a Tertiary Care Hospital in Turkey.","authors":"Ayşe Nur İnci Kenar, Selin Balki Tekin","doi":"10.31083/AP44278","DOIUrl":"10.31083/AP44278","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the safety, tolerability, and efficacy of a newly developed two-injection start (TIS) regimen of aripiprazole once-monthly (AOM) in adult patients diagnosed with bipolar disorder, schizophrenia, or schizoaffective disorder.</p><p><strong>Methods: </strong>This retrospective study included patients diagnosed with schizophrenia, bipolar disorder, or schizoaffective disorder who were regularly followed at our clinic between January 2023 and October 2024 and initiated on the AOM treatment following the TIS regimen. Recorded data included diagnoses, sociodemographic characteristics (age, gender), concurrent psychotropic medications at the time of AOM-TIS initiation, time of hospital discharge following AOM-TIS administration, and details regarding their last AOM treatment.</p><p><strong>Results: </strong>This study included 29 patients (17 females and 12 males; mean age 36.62 ± 12.18 years) who received AOM according to the TIS regimen. AOM was administered as monotherapy in 48.2% of cases. Three patients initiated treatment directly with the AOM-TIS regimen, while nine patients did not receive any concomitant psychotropic medication. Five patients were prescribed mood stabilizers in combination with the AOM-TIS regimen. No serious adverse events, including arrhythmias, severe hyperthermia, impaired consciousness, akathisia, or allergic reactions, were reported following AOM-TIS administration.</p><p><strong>Conclusions: </strong>The AOM-TIS regimen enables the attainment of therapeutic plasma concentrations within a shortened timeframe, facilitating a more rapid clinical response. This approach may contribute to reduced healthcare costs by shortening the duration of hospitalization and enhancing patient adherence, supported by its favorable tolerability profile.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"44278"},"PeriodicalIF":1.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-mental Health in the Age of AI: Data Safety, Privacy Regulations and Recommendations.","authors":"Hanwen Zhang, Yanna Mao, Yibin Lin, Dexing Zhang","doi":"10.31083/AP44279","DOIUrl":"10.31083/AP44279","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"44279"},"PeriodicalIF":1.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric Acid in First-Episode Psychosis: A Systematic Review.","authors":"Daniel Rego, Sofia Ramos Ferreira, Nuno Madeira","doi":"10.31083/AP44248","DOIUrl":"10.31083/AP44248","url":null,"abstract":"<p><strong>Background: </strong>Psychotic disorders such as schizophrenia (SCZ) have been frequently linked with oxidative stress, with uric acid (UA) levels being of particular interest, although evidence remains inconclusive. A possible reduction of UA levels in early phases of SCZ, namely first-episode psychosis (FEP), has been hypothesized. In this systematic review, we aimed to analyze and summarize current evidence regarding UA levels in patients with early psychosis.</p><p><strong>Methods: </strong>We conducted a systematic review of case-control studies comparing serum or plasma UA levels in individuals experiencing FEP with those in healthy controls (HC).</p><p><strong>Results: </strong>Eight studies met the inclusion criteria, with a total sample of 950 individuals that included 520 FEP patients and 430 HC. A tendency for lower UA levels in FEP was described, albeit without definitive evidence, and decreased UA levels were restricted to certain ethnic populations.</p><p><strong>Conclusions: </strong>Our findings do not fully support the hypothesis of an oxidative stress response in early psychosis translatable with reduced UA levels in patients with FEP. Further research is warranted to elucidate the nature and magnitude of the relationship between oxidative stress, UA levels, and early psychosis.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 3","pages":"44248"},"PeriodicalIF":1.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}