Alpha psychiatry最新文献

{"title":"Insights from Tracing the Evolution of Automated Digital Mental Health Interventions in China.","authors":"Jin Han","doi":"10.31083/AP49906","DOIUrl":"https://doi.org/10.31083/AP49906","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 1","pages":"49906"},"PeriodicalIF":3.5,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12957963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147367423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Impairment and Non-Invasive Neuromodulation Interventions in Bipolar Disorder: A Narrative Review of Current Status and Future Directions.","authors":"Guilan Sun, Tongjie Zhuang, Minmin Wang, Xiaomei Zhang","doi":"10.31083/AP42381","DOIUrl":"https://doi.org/10.31083/AP42381","url":null,"abstract":"<p><p>Bipolar disorder (BD) is a severe mental illness characterized by recurrent episodes of mania and depression. The disorder is associated with high rates of relapse and disability, significantly affecting patients' social functioning and quality of life. It is estimated that 30-50% of individuals with BD do not regain their premorbid level of social functioning, primarily due to persistent cognitive impairments. These cognitive deficits are prominent not only during acute episodes but also persist throughout remission, even when emotional symptoms have stabilized. Multiple studies have demonstrated that cognitive dysfunction is widely recognized as a key predictor of relapse, disease progression, and loss of social functioning in individuals with BD. An increasing body of research suggests that the long-term prognosis of BD is closely linked to cognitive impairment, establishing cognitive remediation as a central therapeutic goal for improving social functioning in this population. However, current pharmacological treatments for cognitive deficits show limited efficacy and are frequently associated with notable side effects. Non-pharmacological approaches, particularly neuromodulation techniques, are increasingly recognized for their potential to improve cognitive deficits in BD. This narrative review summarizes the latest findings on neuromodulation interventions for cognitive impairment in BD, with a focus on the current applications and future directions of non-invasive neuromodulation techniques.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 1","pages":"42381"},"PeriodicalIF":3.5,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12957971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147367293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Conventional Facemask Ventilation During Electroconvulsive Therapy in Major Mental Disorders: A Preliminary Open-Label Randomized Controlled Trial.","authors":"Can-Jin Deng, Sha Nie, Rong Zeng, Jian-Xin Mai, Xiong Huang, Shi-Chao Xu, Xin-Hu Yang, Qing-Bin Zeng, Xing-Bing Huang, Wei Zheng","doi":"10.31083/AP39942","DOIUrl":"https://doi.org/10.31083/AP39942","url":null,"abstract":"<p><strong>Background: </strong>Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) technique prolongs apnea duration. However, there is limited knowledge regarding the effectiveness and safety of THRIVE technique compared to conventional facemask ventilation during electroconvulsive therapy (ECT) in Chinese patients with major mental disorders.</p><p><strong>Methods: </strong>Seventy adult individuals with major mental disorders (schizophrenia, n = 17; bipolar disorder, n = 25; major depressive disorder, n = 28) undergoing their first ECT session were assigned to either the THRIVE group (n = 35) or the facemask group (n = 35) based on the random sequence. The primary outcome was the lowest peripheral oxygen saturation (SpO₂) levels. Secondary outcomes included the incidence of oxygen desaturation, electroencephalogram seizure duration, stimulation dosage, mean arterial pressure (MAP), average SpO₂ levels, and heart rate (HR). Airway-related complications were documented within 24 hours following ECT.</p><p><strong>Results: </strong>In the THRIVE group, the lowest SpO₂ levels were notably higher than those in the facemask group (<i>p</i> < 0.05). Patients receiving THRIVE technique had consistently higher average SpO₂ levels than those receiving conventional facemask ventilation (<i>p</i> < 0.05). The incidence of oxygen desaturation in THRIVE group was lower than that in facemask group (<i>p</i> > 0.05). Moreover, significant differences between two study groups were not observed in terms of electroencephalogram seizure duration, stimulation dosage, MAP, and HR (all <i>ps</i> > 0.05). No airway-related complications were reported in either group.</p><p><strong>Conclusions: </strong>In this preliminary open-label randomized controlled trial, the THRIVE technique appeared to be more effective than conventional facemask ventilation in preserving SpO₂ levels during ECT in major mental disorders, establishing itself as a safe and effective oxygenation alternative.</p><p><strong>Trial registration: </strong>No: ChiCTR2400084318, https://www.chictr.org.cn/showproj.html?proj=229304.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 1","pages":"39942"},"PeriodicalIF":3.5,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12957965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147367361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Cited Articles in Evolutionary Psychiatry: Assessment With a Quality and Error Rating Scale.","authors":"Chad Beyer, Chanel Robinson, Dan J Stein","doi":"10.31083/AP39276","DOIUrl":"10.31083/AP39276","url":null,"abstract":"<p><strong>Background: </strong>Evolutionary psychiatry is a growing field that emphasizes the value of evolutionary explanations for traits that make individuals vulnerable to mental disorders. Some articles that apply evolutionary theory in psychiatry make errors, such as viewing a disease as an adaptation. We assessed article quality and error quantity in the most cited articles on evolutionary psychiatry and examined the relationship of these measures to citation number.</p><p><strong>Methods: </strong>PubMed, Web of Science, and Google Scholar were searched in 2023 and again in 2025 using specific terms related to \"evolution\" and \"psychiatry\", to find the most highly cited articles in the field. Based on the work of Nesse, we developed a measure for assessing overall article quality and error quantity in evolutionary psychiatry articles. We applied the measure to the 20 most highly cited articles, and calculated the correlations of article quality and error quantity with number of citations.</p><p><strong>Results: </strong>Twenty highly cited articles, with a mean citation count of 413.30 and publication year from 1964 to 2011, were rated. While the most highly cited articles had good quality on average, they also made important errors. There was no significant correlation of article quality or error quantity with citation count.</p><p><strong>Conclusion: </strong>Highly cited articles in evolutionary psychiatry demonstrated strengths but also weaknesses. The lack of a relationship of article quality and error quantity to citation rates suggests that other factors influence such citations. Future research should focus on achieving consensus on how best to assess the quality of evolutionary psychiatry articles and what errors should be avoided.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 6","pages":"39276"},"PeriodicalIF":3.5,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability Study of the Moodist Outcome Inventory (MOI).","authors":"Pelin Taş, Eslem Fulya Ekşi, Tuğçe Hilal Kadıoğlu, Kültegin Ögel","doi":"10.31083/AP49375","DOIUrl":"10.31083/AP49375","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study is to develop an easily applicable scale to measure the course of treatment and the level of recovery for mental problems in various dimensions, which can be used in clinical practice and research.</p><p><strong>Methods: </strong>The validity and reliability test of Moodist Outcome Inventory (MOI) were conducted with 293 participants. Criterion-related validity was investigated by assessment with the Brief Psychiatric Rating Scale (BPRS), Disability Assessment Schedule (WHO-DAS-II), and Psychological Distress Scale (K10-PDS). Factor analysis was investigated by assessment with clinical and non-clinical samples. The sample was followed for six clinical assessments and evaluated by repetitive analysis of Variance (ANOVA) measurement.</p><p><strong>Results: </strong>The Cronbach's alpha coefficient of the total scale was noted to be 0.89 in the reliability analysis. In the exploratory factor analysis, the single factor explaining 75.64% of the total variance was attained, and all items were included in this factor. Forty cases completed six clinical assessments, and the change between the MOI scores during the time interval was noted to be statistically significant. The correlation of the MOI scale with the K-10, WHO-DAS-II, and BPRS scales was noted to be 0.62, 0.73, and 0.65, respectively. In six consecutive assessments, the mean scores of all scales dropped significantly. The cut-off point of the scale was recorded as 7.27, and the reliable change index (RCI) was noted as 2.5.</p><p><strong>Conclusion: </strong>MOI was assessed as a valid and reliable scale for evaluating the course of treatment. The strengths of the scale are that it assesses both symptoms and well-being, is short, and can be implemented in clinical practice.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 6","pages":"49375"},"PeriodicalIF":3.5,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Repetitive Transcranial Magnetic Stimulation in Treating Alcohol Use Disorder: Neural Mechanisms, Efficacy, and Future Directions.","authors":"Guannan Li, Yinghuan Cao, Jun Zhong","doi":"10.31083/AP49374","DOIUrl":"10.31083/AP49374","url":null,"abstract":"<p><p>Alcohol Use Disorder (AUD) is a global health challenge, affecting 10-15% of the population, with significant social, health, and economic consequences. Although pharmacotherapies such as disulfiram, naltrexone, and acamprosate are available, their effectiveness is limited and patient adherence is often poor. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulation technique that targets neural circuits implicated in addiction. Emerging evidence suggests that rTMS may reduce alcohol craving and consumption, although results have been mixed. This review examines the neural mechanisms by which rTMS may influence AUD, summarizes current clinical evidence of its efficacy, and discusses future directions.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 6","pages":"49374"},"PeriodicalIF":3.5,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety and Depression Among Hepatitis B Inpatients in Shenzhen, China: A Cross-Sectional Study.","authors":"Yanping Chen, Gang Duan, Tao Wang, Xinying Wang, Ting He, Tiantian Liu, Ying He, Xiaoning Liu, Hongzhou Lu","doi":"10.31083/AP49373","DOIUrl":"10.31083/AP49373","url":null,"abstract":"<p><strong>Background: </strong>Chronic hepatitis B (CHB) represents a significant global public health challenge. In China, the disease remains prevalent despite recent reductions in incidence. In addition to its impact on physical health, CHB adversely affects patients' mental health, particularly in the form of anxiety and depression. However, limited research has been conducted on the psychological status of CHB inpatients, especially in metropolitan settings. This study aimed to evaluate the prevalence of anxiety and depression among hospitalized CHB patients in Shenzhen, China, and to investigate factors associated with these mental health conditions.</p><p><strong>Methods: </strong>A cross-sectional study was conducted involving 649 inpatients with chronic hepatitis B at Shenzhen Third People's Hospital. The Hospital Anxiety and Depression Scale (HADS) was used to assess levels of anxiety and depression. Logistic regression analysis was performed to identify factors associated with mental health outcomes.</p><p><strong>Results: </strong>The study revealed that 34.05% of patients experienced anxiety, while 71.65% exhibited symptoms of depression. Depression was more prevalent among older patients and those with multiple hospitalizations. Factors such as lack of health insurance and prolonged hospitalizations were significantly associated with depression. Female patients showed a higher propensity for experiencing anxiety.</p><p><strong>Conclusion: </strong>The high prevalence of anxiety and depression among CHB inpatients highlights the need for integrated mental health screening and intervention strategies within hospital settings. Tailored healthcare approaches are essential to address both the physical and psychological needs of CHB patients, particularly in rapidly urbanizing areas such as Shenzhen.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 6","pages":"49373"},"PeriodicalIF":3.5,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Mindfulness-Based Interventions for Depressive Symptoms and Their Relationship to Interoceptive Awareness: A Systematic Review.","authors":"Samantha Knep, Alice Shires","doi":"10.31083/AP39860","DOIUrl":"10.31083/AP39860","url":null,"abstract":"<p><strong>Background: </strong>This systematic review aimed to investigate the effectiveness of mindfulness-based interventions (MBIs) in treating depression, enhancing interoceptive awareness (IA), and whether IA mediates this relationship.</p><p><strong>Methods: </strong>In August 2024, a comprehensive literature search was conducted in web-based medical and psychological databases, including PsycINFO, MEDLINE, and Scopus, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were included if they were quantitative, peer-reviewed, in English, used MBIs derived from Mindfulness-based Stress Reduction (MBSR), Mindfulness-based Cognitive Therapy (MBCT), or Mindfulness-integrated Cognitive Behavioural Therapy (MiCBT), included a control/comparison group, pre- and post-intervention measures, assessed depressive symptoms and IA in adults over 18, and had at least 20 participants. Exclusion criteria included non-English publications, dissertations, case studies, qualitative research, therapies not derived from the specified MBIs, and studies with under 20 participants or individuals under 18. Methodological quality and risk of bias were assessed.</p><p><strong>Results: </strong>Six studies involving 646 participants met the inclusion criteria. All MBIs (MBCT, MBSR, MiCBT, Mindfulness-based Cancer Recovery, and Mindful Awareness in Body-Oriented Therapy) significantly reduced depressive symptomology and improved IA across varying effect sizes, with IA identified as a partial mediator.</p><p><strong>Conclusions: </strong>MBIs appear to alleviate depressive symptoms and improve IA, with one study finding IA as a mediator. Limitations included limited literature, search term specificity, heterogeneity and mixed evidence quality. Future research should explore IA's mediating role, develop a standardised IA measure, and integrate IA into broader treatment modalities to enhance outcomes.</p><p><strong>The prospero registration: </strong>CRD42023457300, https://www.crd.york.ac.uk/PROSPERO/view/CRD42023457300.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 6","pages":"39860"},"PeriodicalIF":3.5,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Mental Time Travel Research in Adolescent Depression: A Narrative Review.","authors":"Yuan Yuan, Jia-Li Liu, Wan-Ting Ran, Ya Wang, Gui-Fang Chen","doi":"10.31083/AP45509","DOIUrl":"10.31083/AP45509","url":null,"abstract":"<p><p>Adolescent depression is a serious public health issue affecting the mental health and quality of life of adolescents worldwide. Mental time travel (MTT), an individual's capacity to recall the past or look to the future, plays an important role in emotion regulation and mental health. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature search was conducted. Due to considerable heterogeneity among the included studies, a narrative synthesis approach was adopted. A total of 22 articles retrieved from PubMed, Web of Science, PsycINFO, and EBSCO (up to October 31, 2024) were included to elucidate the mechanisms underlying MTT impairments and related interventions in depressed adolescents. The main findings indicated that depressed adolescents exhibit overgeneralization of autobiographical memories, impoverished future simulations, and negative bias in MTT constructs. Neuroimaging studies have revealed aberrant activation within the autobiographical memory network, hyperengagement of the self-referential network during MTT tasks, and alterations in emotion regulation circuits. Furthermore, the efficacy of cognitive therapy and memory/imagery-specific training in ameliorating temporal cognitive biases and fostering positive future expectations was demonstrated. These findings underscore the importance of examining adolescent depression through the lens of MTT, offering a promising framework for understanding its cognitive and neural mechanisms and the development of novel intervention strategies.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 6","pages":"45509"},"PeriodicalIF":3.5,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Characteristics Associated With Methamphetamine Use in Patients With Heroin Use Disorder.","authors":"Zeki Vatansever, İzgi Alnıak, Tonguc D Berkol","doi":"10.31083/AP49341","DOIUrl":"10.31083/AP49341","url":null,"abstract":"<p><strong>Objective: </strong>This study compared addiction severity, psychotic symptoms, suicide risk, and craving in patients with heroin use disorder, with and without methamphetamine use. We also investigated the reasons for methamphetamine use in these patients, and assessed 3-month clinical follow-up and treatment compliance.</p><p><strong>Methods: </strong>This cross-sectional study included 166 inpatients diagnosed with heroin use disorder (DSM-5). Patients were divided into two groups: heroin use only (H), and heroin use + methamphetamine use (H+M). Clinical assessments included the Addiction Profile Index-Clinical Form (API-C), Brief Psychiatric Rating Scale (BPRS), and Suicide Probability Scale (SPS). Statistical analyses were conducted with Statistical Package for the Social Sciences (SPSS) and included descriptive statistics, Kolmogorov-Smirnov test, Chi-square test, Mann-Whitney U test, and logistic regression. Three-month follow-up results and treatment compliance were compared between the two groups.</p><p><strong>Results: </strong>The H and H+M groups included 80 and 86 participants, respectively. The H+M group had higher BPRS total scores, API-C subscale scores (craving, risky behaviors, excitement-seeking, impulsiveness, depression), addiction severity, additional substance use, anxiety, depressive symptoms, suicidal ideation, and 3-month lapse rate. Craving and excitement-seeking were independent predictors of methamphetamine use.</p><p><strong>Conclusion: </strong>The H+M group showed more severe addiction, novelty-seeking personal characteristics, and suicidal ideation compared to the H group. Craving scores were higher in the H+M group and should not be overlooked, along with a greater risk of early lapse. Our study found that craving, risky behaviors, depressive and psychotic symptoms, and suicidal thoughts are the most critical issues to be addressed in the treatment and follow-up of the H+M patient group.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"26 6","pages":"49341"},"PeriodicalIF":3.5,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}