Association of Stmn1 Polymorphism and Cognitive Function: An Observational Study in the Chinese Adults.

IF 1.3 Q3 PSYCHIATRY
Alpha psychiatry Pub Date : 2025-02-28 eCollection Date: 2025-02-01 DOI:10.31083/AP38719
Hui Ma, Zhengtu Cong, Lijuan Liang, Zhaoxia Su, Jing Zhang, Hua Yang, Man Wang
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Abstract

Background: Stathmin1 (Stmn1) is a protein highly expressed during the development of the central nervous system. The phosphorylation of Stmn1 involves microtubule dynamics, so Stmn1 plays a vital part in neurite outgrowth and synaptic plasticity. Previous studies reported that Stmn1 genetic variants influence fear and anxiety as well as cognitive-affective processing. However, no study reported on the relationship between Stmn1 gene polymorphism and cognition in Chinese. Thus, this association was investigated in the present study.

Methods: A total of 129 healthy Han Chinese were genotyped for Stmn1 rs182455 polymorphism by polymerase chain reaction and restriction fragment length polymorphism analyses. Cognitive function was assessed using the Stroop Color-Word Test (SCWT) and Hopkins Verbal Learning Test-Revised (HVLT-R).

Results: In the present sample, rs182455 CC, CT, and TT genotypes were found in 56 (43.41%), 65 (50.39%) and 8 (6.20%) cases, respectively. The genotype distribution did not deviate from Hardy-Weinberg equilibrium (χ2 = 3.715, p = 0.054). Significant differences were found between the three rs182455 genotypes and between the CC and (CT+TT) genotype groups in the Stroop Color (SC) scores of the SCWT (F = 3.322, 2.377; p = 0.039, 0.019, respectively) and the total recall (TR) scores on the HVLT-R (F = 3.118, 2.225; p = 0.048, 0.028, respectively). There was a female-specific difference in SC scores between the three rs182455 genotypes (F = 2.318, p = 0.023). The rs182455 genotype distribution showed no significant difference between two sexes (χ2 = 1.313, p = 0.519), whereas significant differences were seen in SC and TR scores between two sexes (t = -2.294, -2.490; p = 0.023, 0.014, respectively).

Conclusions: The findings suggest that rs182455 Stmn1 polymorphism might affect cognitive flexibility and immediate free recall in healthy Chinese individuals, especially females.

背景:Stathmin1(Stmn1)是一种在中枢神经系统发育过程中高度表达的蛋白质。Stmn1的磷酸化涉及微管动力学,因此Stmn1在神经元突起生长和突触可塑性中起着至关重要的作用。先前的研究报告称,Stmn1 基因变异会影响恐惧和焦虑以及认知情感处理。然而,还没有研究报道中国人的 Stmn1 基因多态性与认知之间的关系。因此,本研究对这一关系进行了调查:方法:通过聚合酶链式反应和限制性片段长度多态性分析,对 129 名健康汉族人进行 Stmn1 rs182455 多态性基因分型。结果表明,rs182455多态性在129名健康汉族人中并不常见:在本样本中,发现 rs182455 CC、CT 和 TT 基因型的病例分别为 56 例(43.41%)、65 例(50.39%)和 8 例(6.20%)。基因型分布没有偏离哈代-温伯格平衡(χ2 = 3.715,P = 0.054)。在 SCWT 的 Stroop 颜色 (SC) 分数(F = 3.322,2.377;p = 0.039,0.019,分别)和 HVLT-R 的总回忆 (TR) 分数(F = 3.118,2.225;p = 0.048,0.028,分别)方面,三种 rs182455 基因型之间以及 CC 和(CT+TT)基因型组之间存在显著差异。三种 rs182455 基因型之间的 SC 分数存在女性特异性差异(F = 2.318,p = 0.023)。rs182455基因型分布在两性之间无显著差异(χ2 = 1.313,p = 0.519),而SC和TR得分在两性之间存在显著差异(t = -2.294,-2.490;p = 0.023,0.014):研究结果表明,rs182455 Stmn1多态性可能会影响中国健康人尤其是女性的认知灵活性和即时自由回忆能力。
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