Association of Children's Dietary Inflammatory Index with Depression and Anxiety Symptoms in Adolescents: Mediating Role of Inflammation and Cardiometabolic Risk Factors.

IF 1.3 Q3 PSYCHIATRY
Alpha psychiatry Pub Date : 2025-02-28 eCollection Date: 2025-02-01 DOI:10.31083/AP38791
Kezban Şahin, Hülya Yardımcı, Murat Açık, Alkım Öden Akman, Fadime Yüksel
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Abstract

Background: Evidence is scarce on the mechanisms involved in the relationship between dietary inflammatory index and mental health in adolescents. This study aimed to assess the association between children-DII (C-DII) and depressive and anxiety disorder symptoms in adolescents and to explore whether inflammation and cardiometabolic risk factors mediate this association.

Methods: The study was conducted at the Ankara City Hospital Pediatrics Polyclinic and 304 adolescents. In cross-sectional study, adolescents were asked general information questions. Anthropometric measurements were performed and some biochemical parameters and inflammation (C-reactive protein (CRP)) were obtained. The C-DII score was calculated from 24-h dietary recalls. Depression and anxiety levels of the participants were assessed by self-report. Structural equation modelling analyzed how cardiometabolic risk factors and inflammation mediate the relationship between mental health and dietary inflammation.

Results: C-DII scores were positively associated with depression and anxiety score (β [95% confidence interval (CI)] = 0.224 [0.08-0.25] for depression; 0.923 [0.04-1.67] for anxiety). Except for dietary inflammation with anxiety in girls, these relationships remained statistically significant in all subgroups by sex. It was determined that CRP partially mediated the relationship between dietary inflammation and depression and anxiety. It was determined that body mass index (BMI)-z score and waist circumference (WC) mediated the relationship between dietary inflammation and depression scores.

Conclusions: Our findings indicate that the higher pro-inflammatory potential of diet is associated with a higher risk of depression and anxiety, and this association may be mediated by CRP for depression and anxiety, WC, and BMI-z score for only depression. Further research is required to verify our findings and clarify the latent mechanism in larger populations.

儿童饮食炎症指数与青少年抑郁和焦虑症状的关系:炎症和心脏代谢危险因素的中介作用
背景:关于青少年饮食炎症指数与心理健康之间关系的机制缺乏证据。本研究旨在评估儿童- dii (C-DII)与青少年抑郁和焦虑障碍症状之间的关系,并探讨炎症和心脏代谢危险因素是否介导这种关联。方法:在安卡拉市立医院儿科综合门诊对304名青少年进行研究。在横断面研究中,青少年被问及一般信息问题。进行了人体测量,并获得了一些生化参数和炎症(c反应蛋白(CRP))。根据24小时饮食回顾计算C-DII评分。参与者的抑郁和焦虑水平通过自我报告进行评估。结构方程模型分析了心脏代谢危险因素和炎症如何介导心理健康和饮食炎症之间的关系。结果:C-DII评分与抑郁和焦虑评分呈正相关(β[95%可信区间(CI)] = 0.224 [0.08-0.25];焦虑(0.923[0.04-1.67])。除了女孩的饮食炎症与焦虑,这些关系在按性别划分的所有亚组中仍然具有统计学意义。确定CRP部分介导了饮食炎症与抑郁和焦虑之间的关系。确定体重指数(BMI)-z评分和腰围(WC)介导饮食炎症与抑郁评分之间的关系。结论:我们的研究结果表明,较高的饮食促炎潜力与较高的抑郁和焦虑风险相关,而这种关联可能是由抑郁和焦虑的CRP、WC和仅抑郁的BMI-z评分介导的。需要进一步的研究来验证我们的发现,并在更大的人群中阐明潜在的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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