Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Rethinking gender differences: An investigation of comorbid psychopathology and alcohol use disorder in veterans.","authors":"William H Craft, Claudia B Padula","doi":"10.1111/acer.15505","DOIUrl":"https://doi.org/10.1111/acer.15505","url":null,"abstract":"<p><strong>Background: </strong>While men have been found to drink more alcohol and have higher rates of alcohol-related mortality, women tend to experience higher rates of alcohol-related consequences, including psychological comorbidities and worse alcohol use disorder (AUD) outcomes. However, gender differences in comorbid psychopathology and associations with AUD outcomes among veterans are less well understood.</p><p><strong>Methods: </strong>Veterans (N = 126; 32 women) receiving inpatient treatment for AUD completed baseline clinical measures including the Beck Depression Inventory-II, Beck Anxiety Inventory, Early Life Stress Questionnaire, and PTSD Checklist for DSM-5. Alcohol use was assessed with the Timeline Followback for the 90 days prior to the baseline assessment and again at 1-, 3-, and 6-month follow-ups. Gender differences in baseline alcohol and psychopathology measures were examined using Fisher's exact test and Mann-Whitney U test. Linear/logistic regression was used to examine associations between comorbid psychopathology and alcohol relapse/use severity post-study.</p><p><strong>Results: </strong>Consistent with prior literature, statistically significant gender differences in psychopathology were observed, with women reporting higher anxiety (p < 0.001), depression (p = 0.001), early life stress (p < 0.001), and PTSD (p < 0.001) at baseline. Higher early life stress was also associated with higher anxiety, depression, and PTSD. Statistically significant gender differences were not observed for alcohol use in the 90 days prior to the study. Similarly, gender was not associated with relapse or severity of use at 1-, 3-, or 6-month follow ups (ps > 0.05). Psychopathology measures were not associated with relapse or severity of use at any time point (ps > 0.05).</p><p><strong>Conclusion: </strong>Our study highlights that women veterans are drinking similar quantities of alcohol to men, supporting emerging evidence of a narrowing gender gap in alcohol use. Women also have a higher psychiatric burden than men; thus, identifying ways to mitigate comorbidity among women veterans should be a health priority.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating sex and line differences in successive negative contrast and ethanol consumption using alcohol preferring and high alcohol drinking rats.","authors":"Nicholle E Smith, Cristine L Czachowski","doi":"10.1111/acer.15535","DOIUrl":"https://doi.org/10.1111/acer.15535","url":null,"abstract":"<p><strong>Background: </strong>The loss of a job or relationship are a couple of examples of unexpected reward loss. Life events, such as these can induce negative emotional reactions (e.g., anxiety and stress), which have been associated with increased alcohol consumption and in turn, an increased risk of developing an alcohol use disorder (AUD). The present study analyzed consummatory successive negative contrast (SNC) for the first time in alcohol preferring (P) and high alcohol drinking (HAD) rats that have been selectively bred to consume high amounts of ethanol. Following reward loss, animals were given free access to ethanol to determine whether consumption would increase as a possible indication of any negative emotional reaction.</p><p><strong>Methods: </strong>Male and female P and HAD rats were split into shifted and unshifted groups receiving either 32% or 4% sucrose for 5 min across 10 preshift days. Subsequently, all animals received 4% sucrose for four postshift days, across which, animals were given access to 20% ethanol for 30 min after access to 4% sucrose.</p><p><strong>Results: </strong>Male and female P rats demonstrated a longer contrast effect than HAD rats, indicated by a longer recovery time following the downshift in reward. Conversely, HAD males did not demonstrate a contrast effect following this downshift in reward unlike their female counterparts. Surprisingly, P rats who experienced a loss of reward consumed significantly less ethanol than animals who did not. Lastly, individual measure of contrast size, or shift ratio, was significantly associated with greater ethanol consumption in HAD males only, who did not display a contrast effect.</p><p><strong>Conclusions: </strong>These data indicate different reactivity to SNC between these two lines and sexes, suggesting different genetic and sex-related mechanisms underlying sensitivity to an unexpected loss of reward and ethanol consumption following this loss.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol-induced liver injury is mediated via α4-containing nicotinic acetylcholine receptors expressed in hepatocytes.","authors":"Jeffrey D Ritzenthaler, Abigail Ekuban, Benjamin Horsman, Jesse Roman, Walter H Watson","doi":"10.1111/acer.15533","DOIUrl":"https://doi.org/10.1111/acer.15533","url":null,"abstract":"<p><strong>Background: </strong>Our previous study demonstrated that alcohol induced the expression of the α4 subunit of nicotinic acetylcholine receptors (nAChRs) in the livers of wild type mice (WT), and that whole-body α4 nAChR knockout mice (α4KO) showed protection against alcohol-induced steatosis, inflammation, and injury. Based on these findings, we hypothesized that hepatocyte-specific α4 nAChRs may directly contribute to the detrimental effects of alcohol on the liver.</p><p><strong>Methods: </strong>Hepatocyte-specific α4 knockout mice (α4HepKO) were generated, and the absence of α4 nAChR was confirmed through PCR of genomic DNA. Female WT and α4HepKO mice were exposed to alcohol in the NIAAA chronic + binge model. After 10 days on the Lieber-DeCarli liquid diet containing 5% (vol/vol) alcohol or isocaloric maltose-dextrin, the mice were gavaged with a single dose of alcohol or isocaloric maltose-dextrin. The mice were euthanized 9 h later and their organs harvested. Additionally, hepatocytes were isolated from WT, α4HepKO, α4floxed, and α4KO mice and exposed to 80 mM alcohol in vitro for 24 h. Steatosis, inflammation, and cell injury were assessed in both liver and isolated hepatocytes.</p><p><strong>Results: </strong>In WT mice, alcohol exposure resulted in hepatic steatosis, inflammation, and injury as evidenced by increased liver triglycerides, neutrophil infiltration, and serum concentrations of liver enzymes. All of these responses were markedly lower in α4HepKO mice. mRNA expression of genes involved in lipogenesis (Srebf1, Fasn, and Dgat2) and inflammation (TNFα, Cxcl5, Cxcl1, and Serpine1) were increased in the livers of WT mice exposed to alcohol in vivo and in WT hepatocytes exposed to alcohol in vitro. These changes were not observed in liver or hepatocytes from mice lacking α4 nAChRs.</p><p><strong>Conclusions: </strong>α4 nAChRs expressed in hepatocytes mediate alcohol-associated hepatoxicity. Therefore, the development of therapeutic strategies targeting hepatocyte α4-containing nAChRs could help reduce the burden of ALD.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articles of Public Interest","authors":"","doi":"10.1111/acer.15530","DOIUrl":"10.1111/acer.15530","url":null,"abstract":"&lt;p&gt;How much alcohol a person drinks is strongly linked to how much their peers drink—and not just among teens and young adults. A new study of mature adults, published in &lt;i&gt;Alcohol: Clinical and Experimental Research&lt;/i&gt;, has found that adults’ social connections influence a person's drinking, both contemporaneously and over time. And, an individual's social network is more influential in changing their drinking behavior over time than other factors, such as their occupation or smoking. The study highlights the importance of understanding social connections in order to design interventions for mature adults who drink heavily. Prior studies have found that peer pressure, family dynamics, and social environment play a critical role in whether adolescents begin and continue to engage in substance use. However, there have been fewer studies of factors contributing to drinking among mature adults, who have more alcohol-related health risks and different social environments, stressors, and coping behaviors than teens and young adults. The current study sought to fill this gap in the research by examining how the drinking behaviors of adults with an average age of 55 years old related to factors such as smoking and their perceived job prestige, as well as the drinking behaviors of their peers. All of the study's analyses of social networks found that, for mature adults, the social environment plays a crucial role in influencing individual drinking behavior. Individual drinking was highly correlated with the contemporaneous drinking behavior of their peers, and, over time, their drinking behavior both influences and is influenced by their social network. People who drank more were more likely to show an increase over time in the proportion of connections with those who drink heavily, while those who drank less showed an increase over time in the proportion of connections who abstain from alcohol. Those who had an increase in the number of heavy drinking connections increased their drinking over time, while those who had an increase in the number of friends or family who abstained from alcohol drank less over time. The study found that higher perceived job prestige tended to be associated with more regular drinking, fewer connections who abstain from alcohol, and less smoking. However, there were no clear associations over time between smoking habits, job prestige, and drinking, suggesting that the social environment is a more influential factor in modifying drinking behavior than smoking or socioeconomic status. Data for this study came from the Framingham Heart Study, an ongoing longitudinal study that began in 1948. Researchers analyzed self-reported information about drinking and smoking behaviors. Social connections consisted of friendships, familial ties, and individuals living at the same address, as obtained through self-report and municipal data. The 30 years of data used for this study were collected between 1971 and 2003, so they may not apply","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"4"},"PeriodicalIF":3.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.15530","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"List of 2024 reviewers","authors":"","doi":"10.1111/acer.15507","DOIUrl":"https://doi.org/10.1111/acer.15507","url":null,"abstract":"<p>Drs. Michael Miles, Laura Nagy, Tammy Chung, and Howard Becker with the Board of Field Editors and the Editorial Office of <i>Alcohol: Clinical and Experimental Research</i> would like to express gratitude to the following investigators who have reviewed manuscripts submitted to the Journal for publication from October 1, 2023, through September 30, 2024. It is the rigor of the peer review process that ultimately determines the quality of the Journal. Your continued support of the Journal is greatly appreciated.</p><p>We apologize if any reviewer has been inadvertently omitted from the list. Please let us know, as we intend to publish an addendum as necessary.\u0000 </p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"256-266"},"PeriodicalIF":3.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.15507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143115714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment-seeking individuals with alcohol use disorder.","authors":"Huaze Gao, Rajita Sinha, Stephanie Wemm, Verica Milivojevic","doi":"10.1111/acer.15529","DOIUrl":"10.1111/acer.15529","url":null,"abstract":"<p><strong>Background: </strong>Chronic alcohol consumption in alcohol use disorder (AUD) is associated with autonomic nervous system dysregulation, increasing cardiovascular risk, and high alcohol cravings. Heart rate variability (HRV), a marker of autonomic nervous system responsiveness to stressors, may mediate alcohol's impact on the cardiovascular system. While pregnenolone (PREG) has been shown to normalize heart rate and blood pressure in individuals with AUD, its effects on sympathetic and parasympathetic components of HRV and related alcohol craving are not known.</p><p><strong>Methods: </strong>Fifty-five treatment-seeking individuals with AUD were randomized to placebo (n = 21) or daily pregnenolone at 300 mg (n = 18) or 500 mg (n = 16), in a double-blind, 8-week pilot clinical trial. In week 2, participants underwent three randomized, counterbalanced 5-minute personalized guided imagery provocations (stress, alcohol, and neutral/relaxing cues) on separate days. HRV indices were assessed during each session and analyzed using linear mixed-effects models (LMEs), including association between HRV indices and anxiety and alcohol craving.</p><p><strong>Results: </strong>A medication group × condition interaction was found for parasympathetic, high-frequency (HF) (p = 0.028) and sympathetic/parasympathetic, low-frequency/high-frequency (LF/HF) ratio (p = 0.017) indices of HRV. Placebo had higher HF during alcohol cue (p = 0.011), while 500 mg PREG demonstrated lower HF in response to stress (p = 0.050) and alcohol cues (p = 0.047). Placebo showed lower LF/HF ratio during stress (p = 0.006) and alcohol cue (p = 0.001), while the PREG groups showed no changes. Overall, the LF/HF response to alcohol cue was significantly lower in placebo compared to the 300 mg PREG (p = 0.012) and 500 mg PREG (p = 0.037) groups. Lastly, HF was found to predict alcohol craving regardless of PREG doses.</p><p><strong>Conclusions: </strong>We found a normalization of autonomic response in PREG groups. These findings suggest that PREG holds therapeutic potential for enhancing autonomic function in AUD.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmonization of alcohol use data and mortality across a multi-national HIV cohort collaboration.","authors":"Suzanne M Ingle, Adam Trickey, Anastasia Lankina, Kathleen A McGinnis, Amy Justice, Matthias Cavassini, Antonella d' Arminio Monforte, Ard van Sighem, M John Gill, Heidi M Crane, Niels Obel, Inma Jarrin, Elmar Wallner, Jodie Guest, Michael J Silverberg, Georgia Vourli, Linda Wittkop, Timothy R Sterling, Derek D Satre, Greer A Burkholder, Dominique Costagliola, Jonathan A C Sterne","doi":"10.1111/acer.15522","DOIUrl":"https://doi.org/10.1111/acer.15522","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use is measured in diverse ways across settings. Harmonization of measures is necessary to assess effects of alcohol use in multi-cohort collaborations, such as studies of people with HIV (PWH).</p><p><strong>Methods: </strong>Data were combined from 14 HIV cohort studies (nine European, five North American) participating in the Antiretroviral Therapy Cohort Collaboration. We analyzed data on adult PWH with measured alcohol use at any time from 6 months before starting antiretroviral therapy. Five cohorts measured alcohol use with AUDIT-C and others used cohort-specific measures. We harmonized alcohol use as grams/day, calculated using country-level definitions of a standard drink. For Alcohol Use Disorders Identification Test (AUDIT-C), we used Items 1 (frequency) and 2 (number of drinks on a typical day). Where alcohol was measured in categories, we used the mid-point to calculate grams/day. We used multivariable Cox models to estimate associations of alcohol use with mortality.</p><p><strong>Results: </strong>Alcohol use data were available for 83,424 PWH, 22,447 (27%) had AUDIT-C measures and 60,977 (73%) recorded the number of drinks/units per week/day. Of the sample, 19,150 (23%) were female, 54,006 (65%) had White ethnicity, and median age was 42 years. Median alcohol use was 0.3 g/day (interquartile range [IQR] 0-4.8) and 0 g/day (IQR 0-20) for those with and without AUDIT-C. There was a J-shaped relationship between grams/day and mortality, with higher mortality for PWH reporting no alcohol use (adjusted hazard ratio [aHR] 1.46; 95% CI: 1.23-1.72) and heavier (>61.0 g/day) alcohol use (aHR 1.92; 1.41-2.59) compared with 0.1-5.5 g/day among those with AUDIT-C measures. Associations were similar among those with non-AUDIT-C measures.</p><p><strong>Conclusions: </strong>Grams/day is a useful metric to harmonize diverse measures of alcohol use. Magnitudes of associations of alcohol use with mortality may differ by setting and measurement method. Higher mortality among those with heavier alcohol use strengthens the case for interventions to reduce drinking.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of chronic ethanol consumption and SARS-COV-2 on the liver and intestine: A pilot dose-response study in mice.","authors":"Smita Ghare, Dennis Warner, Jeffrey Warner, Paula M Chilton, Jiyeon Lee, JingWen Zhang, Min Wang, Josiah Hardesty, Rui Treves, Jon Gabbard, Charles Anderson, Lalit Batra, Chithra Sreenivasan, Jennifer Kraenzle, Matthew McCulley, Stephanie McCoy, Lihua Zhang, Wenke Feng, Dibson Dibe Gondim, Shirish Barve, Jian Zheng, Kenneth Palmer, Craig McClain, Irina Kirpich","doi":"10.1111/acer.15528","DOIUrl":"10.1111/acer.15528","url":null,"abstract":"<p><strong>Background: </strong>During the coronavirus disease 2019 (COVID-19) pandemic, there was a marked increase in alcohol consumption. COVID-19 superimposed on underlying liver disease notably worsens the outcome of many forms of liver injury. The goal of a current pilot study was to test the dual exposure of alcohol and COVID-19 infection in an experimental animal model of alcohol-associated liver disease (ALD).</p><p><strong>Methods: </strong>After 4 weeks of ethanol (EtOH) feeding, C57BL/6 male mice received SARS-CoV-2 (SARS2-N501Y_MA30) intranasally at 3 × 10², 1 × 10³, 3 × 10³, and 1 × 10⁴ plaque-forming units (PFU). Mice were then weighed/monitored daily for morbidity/mortality for 10 days while continuing EtOH consumption. Markers of liver inflammation, injury, and intestinal barrier integrity were evaluated.</p><p><strong>Results: </strong>A similar gradual weight loss was observed in all inoculated mice (slightly less in the 3 × 10² group) up to post-infection day 4. Greater mortality was observed in mice receiving the highest viral dose at days 3 and 4 post-infection. The majority of the surviving mice subjected to EtOH and inoculated with 3 × 10³ or 1 × 10⁴ PFU rapidly lost 25% of their body weight and were euthanized on post-infection day 4. Analysis of liver health in animals that survived to the end of the experiment exhibited no significant changes in hepatic steatosis but had a limited increase in plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels at all viral doses versus EtOH alone. However, the 1 × 10⁴ PFU viral dose exacerbated EtOH-induced hepatic inflammation characterized by elevated levels of several pro-inflammatory cytokines, including Il-6 and Tnf-α. There was limited effect of viral infection on the intestine.</p><p><strong>Conclusions: </strong>SARS-CoV-2 infection caused a dose-dependent negative impact on body weight and survival in mice fed EtOH. This pilot study suggests that early mortality observed after high-dose SARS-CoV-2 challenge could be due, in part, to hepatic dysfunction following chronic EtOH feeding.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High prevalence of alcohol use disorders in 454 young adult offspring from the San Diego prospective study.","authors":"Marc A Schuckit, Tom L Smith, Lee Anne Mendoza, George Danko, Hannah Fisher, Camarin Laurance","doi":"10.1111/acer.15519","DOIUrl":"https://doi.org/10.1111/acer.15519","url":null,"abstract":"<p><strong>Background: </strong>Preliminary evaluations of 212 drinking offspring from the San Diego Prospective Study (SDPD) indicated that over 50% developed alcohol use disorder (AUD) by their mid-20s. The present analysis evaluated if those findings remained robust when the group increased to 454 individuals, a sample size that facilitated a search for potential contributors to the high AUD prevalence.</p><p><strong>Methods: </strong>Semistructured interviews were used to evaluate lifetime AUD diagnoses in 224 daughters and 230 sons from the SDPS (N = 454) by mean age 26. Analyses compared participants with and without AUD regarding demography, alcohol use, personality, and psychiatric diagnoses. Characteristics associated with AUD were entered together in a backward elimination regression analysis, and the results were entered in a structural equation model (SEM) to evaluate potential mediation of risks for alcohol problems.</p><p><strong>Results: </strong>Lifetime AUD was documented for 61% of the sons and 41% of the daughters. Offspring with AUD reported averages of 13 maximum and five usual drinks per occasion and endorsed an average of 4 DSM AUD criteria. Even after considering personality characteristics, family AUD histories, and personal psychiatric histories, significant contributions to the regression analysis were limited to lower levels of response to alcohol, higher positive alcohol expectancies, and drinking to cope. Key elements of the hypothesized SEM were supported, and mediation between the low alcohol response and the number of alcohol problems was documented for expectancies, drinking to cope, and peer heavier drinking.</p><p><strong>Conclusion: </strong>The results support prior high AUD rates in SDPS offspring and demonstrate that the AUD diagnoses were associated with robust alcohol intake and problems. The data also indicated mediation of the impact of the low alcohol response on the development of AUD through several characteristics proposed by prior work in other populations.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The need to consider other substance use and the heterogeneity of simultaneous alcohol and cannabis use occasions: A commentary on Farrelly et al.","authors":"Ashley N Linden-Carmichael, Jennifer L Shipley","doi":"10.1111/acer.15526","DOIUrl":"10.1111/acer.15526","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}