Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Contingency management and the expanding role of hepatology in alcohol use disorder.","authors":"Mohammed Abdulrasak","doi":"10.1111/acer.70118","DOIUrl":"https://doi.org/10.1111/acer.70118","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144664117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal person-centered analysis of anxiety sensitivity risk for young adult alcohol misuse: Examining the role of injunctive norms.","authors":"Charlotte Corran, Alexandre J S Morin, Christian S Hendershot, Roisin M O'Connor","doi":"10.1111/acer.70113","DOIUrl":"https://doi.org/10.1111/acer.70113","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use and problems increase during adolescence and peak in early adulthood. Tension reduction theory points to anxiety sensitivity as a risk factor for alcohol misuse, and the theory of planned behavior suggests that injunctive norms (i.e., perceived approval of risky drinking) may be central to this risk trajectory.</p><p><strong>Methods: </strong>This study utilized a longitudinal person-centered approach to identify unique patterns of injunctive norms (by three referent groups: typical students, friends, and parents) among 223 college students (M_age = 18.82, 62.2% women).</p><p><strong>Results: </strong>Latent profile analyses revealed three distinct injunctive norm profiles, which proved to be identical across the three measurement points. These profiles were characterized by mixed levels of perceived approval (high typical students, neutral friends, low parents; Mixed Tolerance profile), low levels of perceived approval (low typical students, friends, parents; Low Tolerance profile), and high levels of perceived approval (high typical students and friends, neutral parents; High Tolerance profile). Student membership in these profiles was moderate to highly stable over time. A higher level of anxiety sensitivity was associated with membership in profiles characterized by high perceived approval of risky drinking. The Mixed Tolerance profile was associated with the least amount of alcohol misuse and problems (protective), the Low Tolerance profile was associated with some risk, and the High Tolerance profile was associated with the most risk.</p><p><strong>Conclusion: </strong>Our findings demonstrate the nature and stability of injunctive norm profiles and offer new insight into the role of injunctive norm topologies in Alcohol-Related Social Risk (AS-risk) for young adult alcohol misuse and related problems.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does paternal alcohol consumption affect the severity of traits of fetal alcohol spectrum disorders?","authors":"Philip A May, Julie M Hasken, Jason Blankenship, Anna-Susan Marais, J Phillip Gossage, Wendy O Kalberg, Marlene De Vries, Luther K Robinson, David Buckley, Melanie Manning, Charles D H Parry, H Eugene Hoyme, Barbara Tabachnick, Soraya Seedat","doi":"10.1111/acer.70105","DOIUrl":"10.1111/acer.70105","url":null,"abstract":"<p><strong>Background: </strong>Animal models suggest that paternal alcohol consumption may influence offspring traits, yet few human studies exist.</p><p><strong>Methods: </strong>Data from population-based studies of fetal alcohol spectrum disorders (FASD) among first-grade students provided case-control data to explore traits of fathers of children with: FASD, alcohol exposure, and unexposed controls.</p><p><strong>Results: </strong>Most males in this population drank, but more fathers of children with FASD drank during pregnancy ( <math> <semantics> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> <annotation>$$ overline{x} $$</annotation></semantics> </math> = 73.2%) than fathers of controls ( <math> <semantics> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> <annotation>$$ overline{x} $$</annotation></semantics> </math> = 63.4%). Among drinkers, fathers of children with FASD: (a) consumed more drinks per occasion than controls ( <math> <semantics> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> <annotation>$$ overline{x} $$</annotation></semantics> </math> = 11.5 vs. 9.7 for maternally exposed controls and 8.1 for maternally unexposed controls), (b) drank more frequently and binged, and (c) were reported to have had a drinking problem ( <math> <semantics> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> <annotation>$$ overline{x} $$</annotation></semantics> </math> = 27.8% vs. <math> <semantics> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> <annotation>$$ overline{x} $$</annotation></semantics> </math> = 18.8%). Partial correlations, controlling for maternal average drinks per drinking day (DDD) by trimester and maternal tobacco use, indicated a significant, negative association between paternal heavy/binge drinking (≥5) and child outcomes resulting in a significant reduction in child height, head circumference, and verbal IQ. Categorical analysis of combined levels of maternal and paternal drinking indicated a significant mean reduction in child height, head circumference, and verbal IQ centile, and a significant increase in total dysmorphology score, did not occur without maternal drinking. Combined paternal and maternal drinking pattern analysis also indicated that paternal drinking was not independently associated with child total dysmorphology scores or neurocognitive outcomes. Models of maternal and paternal drinking were significant, but main and significant effects on total dysmorphology and neurocognitive outcomes were via maternal alcohol consumption. Likewise, paternal alcohol consumption was not independently associated with an FASD diagnosis when controlling for prenatal maternal alcohol and tobacco use.</p><p><strong>Conclusions: </strong>Paternal alcohol consumption was associated with an independent, negative influence on child height, head circumference, and verbal IQ. Maternal drinking, when combined with heavy male drinking, was associated with more severe FASD outcomes.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant treatment of alcohol associated liver disease and alcohol use disorder in the nontransplant setting: A scoping review.","authors":"Sawsan Fathma, Sherry A McKee, Alyssa A Grimshaw, Sarpong Boateng, David A Fiellin, Lamia Haque, Wajahat Z Mehal, Bubu A Banini","doi":"10.1111/acer.70112","DOIUrl":"https://doi.org/10.1111/acer.70112","url":null,"abstract":"<p><p>Alcohol-associated liver disease (ALD) is a leading cause of liver-related deaths in the United States and worldwide, occurring in persons with alcohol use disorder (AUD). Effective treatment of AUD is essential to curtail the progression of ALD and/or reverse the disease course, yet there is a paucity of information on care models for the concomitant treatment of AUD in persons with ALD, particularly when liver transplant is not imminent or warranted. Here, we reviewed existing literature on care models for the concomitant treatment of ALD and AUD among individuals not undergoing liver transplant evaluation or consideration. A comprehensive search of electronic databases including Cochrane Library, CINAHL, Ovid MEDLINE, Ovid Embase, Scopus, Google Scholar, PubMed, and Web of Science Core Collection from inception to July 2024 was conducted to identify original studies reporting care for both ALD and AUD in persons not undergoing liver transplant evaluation or consideration. From the 1146 publications identified, 43 studies were selected for further review, of which three articles were selected for data charting and inclusion in the review. Concomitant treatment of ALD and AUD were implemented both within inpatient and outpatient settings, with multidisciplinary care teams typically involving hepatology and addiction medicine and/or addiction psychiatry. One study showed that attention and care for AUD led to improvement in liver disease and a decrease in emergency department visits and frequency of hospitalization. The studies reviewed suggest that concomitant care for ALD and AUD in the nontransplant setting may improve outcomes for some patients. The limited number of studies highlights the need for more prospective and longitudinal studies evaluating concomitant treatment, especially in persons for whom liver transplant may not be an option or a consideration.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disturbances relate to problematic alcohol use via effortful control and negative emotionality.","authors":"Matison W McCool, Chloe E Martinez, Maria M Wong, Matthew R Pearson","doi":"10.1111/acer.70080","DOIUrl":"https://doi.org/10.1111/acer.70080","url":null,"abstract":"<p><strong>Background: </strong>Sleep disturbances, such as insomnia, are highly prevalent among college students. Alcohol use (and other substance use) peaks during emerging adulthood (18-25 years old). Short sleep duration and sleep disturbances have been shown to be a risk marker for the development of problematic alcohol use. Putative mechanisms that account for this relationship include facets of executive functioning and emotion regulation.</p><p><strong>Methods: </strong>In a large cross-sectional sample of college students (n = 5074), we examined the relationship between insomnia symptoms and problematic alcohol use (negative consequences and alcohol use disorder symptoms) via negative emotionality (stress, depression, anxiety, social anxiety) and effortful control (activation, attentional, and inhibitory) using structural equation modeling with bootstrapping (CFI = 0.979, TLI = 0.971, RMSEA = 0.038 [90% CI: 0.035, 0.041], SRMR = 0.045).</p><p><strong>Results: </strong>Insomnia symptoms were associated with higher negative emotionality (β = 0.539, p < 0.001) and lower effortful control (β = -0.283, p < 0.001); negative emotionality (β = 0.207, p < 0.001) and effortful control (β = -0.267, p < 0.001) were each related to problematic alcohol use. The relationship between insomnia and problematic alcohol use (β = 0.173, p < 0.001) dropped to nonsignificance when controlling for negative emotionality and effortful control (β = -0.014, p = 0.698).</p><p><strong>Conclusions: </strong>Although the cross-sectional nature of the data prohibits causal inference, these indirect effects support the plausibility that facets of executive functioning and emotion regulation account for the relationship between insomnia symptoms and problematic alcohol use. Understanding the relationships among these factors can help guide the development and tailoring of effective interventions that target sleep-alcohol use dynamics.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the GLP-1 receptor agonist exenatide on pro-inflammatory and metabolic biomarkers in individuals with alcohol use disorder: Post hoc results from a randomized, double-blinded, placebo-controlled clinical trial.","authors":"Malthe E B Hviid, Lea A N Christoffersen, Mette K Klausen, Thorsten Brodersen, Ole B Pedersen, Sisse R Ostrowski, Margit H Larsen, Mette Kongstad, Mathias E Jensen, Tina Vilsbøll, Anders Fink-Jensen","doi":"10.1111/acer.70110","DOIUrl":"https://doi.org/10.1111/acer.70110","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use disorder (AUD) has been associated with inflammation, metabolic syndrome, and increased risk of all-cause mortality. This study aimed to compare the pro-inflammatory and metabolic biomarker profiles in individuals with AUD with individuals without AUD, and to evaluate the effect of exenatide on these biomarkers in individuals with AUD.</p><p><strong>Methods: </strong>Serum concentrations of 25 biomarkers (interferon-γ [IFN-γ], tumor necrosis factor-α [TNF-α], interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, monocyte chemoattractant protein-1 [MCP-1], C-peptide, gastric inhibitory polypeptide [GIP], glucagon-like peptide [GLP-1], glucagon, insulin, leptin, pancreatic polypeptide [PP], adiponectin, high sensitivity C-reactive protein [hsCRP], fibroblast growth factor 21 [FGF-21], total cholesterol [CHOL], high-density lipoprotein [HDL], low-density lipoprotein [LDL], and triglycerides [TG]) from individuals with AUD were measured at baseline and after 26 weeks of treatment with the GLP-1 receptor agonist (GLP-1RA) exenatide once-weekly or placebo, using multiplexed immunoassays, enzyme-linked immunosorbent assay (ELISA), and line immunoassays. Serum samples from 23 individuals with no record of AUD or treatment with a GLP-1RA were measured once for comparison with individuals with AUD.</p><p><strong>Results: </strong>IL-6 (1.56 vs. 0.62 pg/mL), hsCRP (3.30 vs. 1.34 mg/L), and FGF-21 (1794.97 vs. 306.11 pg/mL) were significantly higher, whereas GIP (63.06 vs. 111.07 pg/mL) was significantly lower in individuals with AUD (n = 124) than in those without AUD (n = 23). No significant changes in biomarker levels were observed after treatment with exenatide (n = 40) compared with treatment with placebo (n = 37).</p><p><strong>Conclusion: </strong>Our findings support the well-established link between AUD and inflammation. However, treatment with the GLP-1 receptor agonist exenatide did not impact pro-inflammatory and metabolic biomarkers.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An ecological momentary assessment study of predictors for alcohol outcomes in transgender and gender diverse youth.","authors":"Sarah S Dermody, Stephanie M Penta, Theodore Forest Quinn, Alexandra Uhrig, Jeffrey D Wardell, Trevor A Hart, Christian S Hendershot, Elizabeth Saewyc, Alex Abramovich","doi":"10.1111/acer.70081","DOIUrl":"https://doi.org/10.1111/acer.70081","url":null,"abstract":"<p><strong>Background and aims: </strong>This study examined how gender minority stressors and resilience experienced by transgender and gender diverse (TGD) youth relate to daily and momentary occurrences of alcohol use risk processes (e.g., alcohol craving, drinking motives, and distress), alcohol use, and alcohol-related harms. The feasibility of ecological momentary assessment (EMA) was evaluated.</p><p><strong>Methods: </strong>Forty TGD youth (mean 22.42 years [SD = 3.03]; range 18-29) completed a baseline interview followed by 21 days of EMA. Daily morning surveys assessed stressors and resilience, alcohol risk processes, use and harms experienced \"yesterday\" and twice-daily random surveys assessed most of these experiences in the \"past 30 min\" or \"right now.\"</p><p><strong>Results: </strong>Using multilevel models, at the daily (within-person) level, gender minority stressors were significantly related to increased alcohol use (incidence rate ratio (IRR) = 1.16, 95% confidence interval [CI]: 1.03-1.32), drinking to cope (B = 0.16, 95% CI: 0.06-0.26), psychological distress (B = 0.19, 95% CI: 0.03-0.35) and alcohol craving (B = 0.05, 95% CI: 0.01-0.10), but not alcohol harms or negative affect. At the momentary (within-person) level, gender minority stress was associated with increased drinking to cope (B = 0.76, 95% CI: 0.51-1.01), alcohol craving (B = 0.43, 95% CI: 0.31-0.55), and negative affect (B = 2.17, 95% CI: 1.31-3.02). Daily resilience was also associated with increased alcohol use (IRR = 1.32, 95% CI: 1.15-1.52), but not craving or negative affect. Momentary resilience was associated with reduced drinking to cope (B = -0.56, 95% CI: -0.88, -0.23) and negative affect (B = -0.52, 95% CI: -0.81, -0.23), but not craving. Adherence rates and participants' ratings about study acceptability were favorable.</p><p><strong>Conclusions: </strong>Gender minority stressors are a risk factor for same-day alcohol use. Resilience factors may be associated with increased alcohol use through other mechanisms (e.g., drinking for social or conformity reasons). Interventions to reduce TGD youth's alcohol use should address gender minority stressors and support TGD youth to cope with these stressors.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal alcohol exposure worsens acute but not long-term cognitive outcomes due to stroke in middle-aged Sprague-Dawley rat offspring.","authors":"Shameena Bake, Marisa R Pinson, David A Hurst, Brendan O'Reilly, Nadia Samiya, Rajesh C Miranda, Farida Sohrabji","doi":"10.1111/acer.70079","DOIUrl":"https://doi.org/10.1111/acer.70079","url":null,"abstract":"<p><strong>Background: </strong>Prenatal alcohol exposure (PAE) is the major cause of developmental disability, ultimately resulting in a wide range of long-term health consequences across the lifespan. PAE adults are at increased risk for metabolic, immune, and cardiovascular disease, and neurocognitive disabilities. However, little is known about the contribution of PAE to adult-onset cerebrovascular disease, specifically ischemic stroke during middle age, a time when stroke incidence and severity typically increase. We hypothesized that PAE would exacerbate both acute consequences and long-term cognitive impairment due to an ischemic stroke in middle age.</p><p><strong>Methods: </strong>Pregnant Sprague-Dawley rats were exposed episodically to ethanol during the fetal neurogenic period. Middle-aged offspring (12 months old, male and female) from PAE and control dams were subjected to endothelin-1 induced unilateral middle cerebral artery occlusion (MCAo). Separate cohorts of animals were evaluated at 2 days after stroke for neurological and sensorimotor deficits, infarct volume, immune cell types, cytokines, and endocrine factors, and at 3 months after stroke for persistent changes in cognitive function.</p><p><strong>Results: </strong>In the acute phase, PAE increased brain infarct volume, with an increased expression of proinflammatory mediators in the ischemic hemisphere, paralleled by a reduced CD4:CD8 ratio in circulation. Stroke-induced neurological and sensorimotor deficits were worse in PAE females compared with control females. However, despite the impact of PAE on acute phase outcomes, this treatment did not significantly modify either associative learning (fear conditioning), episodic memory (novel object recognition) or spatial learning (Barnes maze) in the chronic phase.</p><p><strong>Conclusions: </strong>These data show that PAE did exacerbate acute stroke outcomes in middle-aged offspring, but did not additionally impair long-term cognitive performance after stroke.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aversion-resistant alcohol seeking in the human laboratory.","authors":"A C S Garrison, W Wu, M R Cox, D Haines, J Hays, M K Mlungwana, A E K Kosobud, D A Kareken, S O'Connor, M H Plawecki, M A Cyders","doi":"10.1111/acer.70078","DOIUrl":"10.1111/acer.70078","url":null,"abstract":"<p><strong>Background: </strong>Aversion-resistant, or \"compulsive,\" drinking is well-studied as a preclinical model of alcohol use disorder. Human studies have largely relied on subjective self-report of aversion-resistant drinking. The goal of this study was to develop and test a behavioral model of aversion-resistant alcohol seeking in the human laboratory, facilitating translational research on this important risk factor.</p><p><strong>Methods: </strong>A sample of 84 adults aged 21-55 (mean age = 32.2 years, 54.8% female, 58.3% white) who endorsed heavy alcohol use (mean AUDIT = 11.3, SD = 5.6) completed an interview/screening session and two counterbalanced progressive-ratio intravenous alcohol self-administration sessions, one in which alcohol seeking was paired with aversive and the other neutral stimuli (each beginning with a 40-min alcohol prime of 60 mg/dL). Study hypotheses were preregistered at clinicaltrials.gov (Study Details-Human Alcohol Seeking Despite Aversion-ClinicalTrials.gov, ID NCT03648840).</p><p><strong>Results: </strong>Contrary to hypotheses, across the whole sample, cumulative lifetime drinking did not relate specifically to aversion-resistant alcohol seeking; rather, those with more extensive drinking histories worked more for alcohol across both sessions. A parallel growth curve model analysis found that less of an alcohol-prime-associated increase in stimulation was related to more aversion-resistant alcohol seeking.</p><p><strong>Conclusions: </strong>These data suggest that aversion-resistant alcohol seeking may stem from the blunted stimulating effects of alcohol, consistent with the low-level response theory driving excessive alcohol seeking, or from acquired tolerance from drinking. This human model of aversion-resistant alcohol seeking can be paired with preclinical models to explore and evaluate new clinical treatment targets.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the relationship between cannabis use and drinking levels on co-use days.","authors":"Holly K Boyle, Alexander W Sokolovsky, Rachel L Gunn, Jordan A Gette, Helene R White, Kristina M Jackson","doi":"10.1111/acer.70107","DOIUrl":"https://doi.org/10.1111/acer.70107","url":null,"abstract":"<p><strong>Background: </strong>Co-use of alcohol and cannabis among young adults is often associated with more alcohol consumption than alcohol-only use, yet little work has examined cannabis use specifically during heavy drinking. Much of the work examining heavy drinking has focused on heavy episodic drinking (HED, 4+/5+ drinks/occasion for females/males); however, young adults report drinking levels that far exceed this, frequently reporting high-intensity drinking (HID; 8+/10+ drinks/occasion for females/males), double the HED threshold, which confers greater risk of acute negative consequences. This study examined whether day-level co-use (vs. alcohol-only use) was associated with greater odds of heavier drinking levels: HID vs. HED vs. moderate drinking (1-3/1-4 drinks/occasion for females/males). We explored whether within-person variations in cannabis use characteristics (frequency, form, and quantity) differentiated moderate drinking, HED, and HID on co-use days.</p><p><strong>Methods: </strong>Young adults who reported simultaneous alcohol and cannabis use (N = 318) from three US universities completed five repeated daily surveys for 54 days reporting number of drinks and number of cannabis uses (i.e., frequency/events), forms, and quantity.</p><p><strong>Results: </strong>Participants reported increased likelihood of HID and HED versus moderate drinking on co-use versus alcohol-only days. HID versus HED did not differ between co-use and alcohol-only days. On co-use days, heavier drinking was more likely on days with more cannabis use. The form of cannabis used and the use of multiple versus single forms of cannabis were not associated with drinking level. Yet, HID was more likely than HED and moderate drinking when more grams of flower were used and HID was also more likely than moderate drinking when more hits of concentrates were used.</p><p><strong>Conclusions: </strong>Findings show heavy drinking (HID, HED) was more likely than moderate drinking on co-use days and cannabis use characteristics may influence drinking levels. Co-use interventions may benefit from a focus on heavy drinking and cannabis use characteristics.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}