Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Age 18–30 Trajectories of Beverage-Specific Binge Drinking Prevalence Over 30 Years for Men and Women in the United States","authors":"Justin Jager,&nbsp;Jin Yan,&nbsp;Paul Espinoza,&nbsp;Megan E. Patrick,&nbsp;Katherine M. Keyes","doi":"10.1111/acer.70420","DOIUrl":"10.1111/acer.70420","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Binge drinking contributes to substantial mortality, morbidity, and economic costs in the United States. Although trends in and determinants of overall binge drinking are well characterized, little is known about how binge drinking trends vary by beverage type (beer, wine, liquor) across young adulthood and over historical time. Understanding beverage-specific patterns may clarify shifts in alcohol-related risks and inform beverage-specific policy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were drawn from the Monitoring the Future longitudinal study, which sampled representative cohorts of US high-school seniors from 1976 through 2008 and followed them across seven waves through age 30 from 1988 through 2020 (<i>N</i> = 20,684). Piecewise latent-growth models assessed age trends, cohort trends, and age-by-cohort interactions in overall, beer, wine, and liquor binge drinking prevalence separately for each sex.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For both sexes, overall binge drinking followed an inverted U pattern across age (increases from age 18–22, decreases through age 30); beer and liquor binge drinking followed the overall inverted U pattern, whereas wine was flat. Cohort trends varied sharply by age and differentially so by beverage type. For both sexes, historical decreases in overall binge drinking at the outset of young adulthood (age 18) were a function of historical decreases in beer and wine. However, due to historical increases in liquor and wine during the latter portion of young adulthood, for both sexes age 18 decreases in overall binge drinking were not maintained through age 30, where levels were flat for men and increased for women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Beverage-specific trends reveal that historical declines in binge drinking at younger ages of young adulthood are concentrated in beer and wine, whereas increases in liquor and wine at older ages offset these initial declines. Beverage-specific policies with evidence-based efficacy and cost effectiveness, such as increasing price and reducing availability, may help reduce emerging risks related to liquor and wine binge drinking.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol Use Trajectories Across Disasters: Associations With Depression and Illness Anxiety","authors":"Lynsay Ayer,&nbsp;Samer Atshan,&nbsp;Rachana Seelam,&nbsp;Bonnie Ghosh-Dastidar,&nbsp;Alyson B. Harding,&nbsp;Andrew Parker,&nbsp;Vanessa Parks","doi":"10.1111/acer.70389","DOIUrl":"10.1111/acer.70389","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol use often fluctuates following disasters, but individual trajectories and their links to mental health remain poorly understood. This study examined long-term patterns of alcohol use among disaster-exposed adults and their associations with depression and illness anxiety (a preoccupation with having or acquiring a serious illness).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data (<i>N</i> = 941) came from five waves (2016–2024) of the <i>Survey of Trauma, Resilience, and Opportunity among Neighborhoods in the Gulf (STRONG)</i>, a longitudinal cohort of adults in the U.S. Gulf Coast region. Growth mixture modeling identified latent trajectories of alcohol use across nine years encompassing multiple disasters (Deepwater Horizon oil spill, hurricanes, COVID-19 pandemic). Multinomial regression examined demographic and disaster exposure correlates of trajectory membership. Linear mixed-effects models assessed associations between drinking trajectories and longitudinal changes in depression and illness anxiety.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A four-class model best fit the data: <i>Low Stable</i> (36%), <i>Elevated Stable</i> (47%), <i>Decreasing</i> (11%), and <i>Increasing</i> (7%) drinking trajectories. Elevated Stable drinkers were younger, more educated, and less likely to be female or Black. Disaster exposure differed modestly by class, with only oil spill exposure and COVID-19 disruptions associated with drinking patterns. Over time, depression increased among Elevated Stable and Increasing drinkers, while illness anxiety rose among Elevated Stable and Decreasing drinkers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Alcohol use and mental health trajectories following disasters are heterogeneous and interrelated. Persistent or increasing drinking was linked to worsening depression, while illness anxiety followed distinct patterns. Tailored prevention and intervention strategies should consider individual drinking trajectories and disaster context.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Neurodevelopmental Outcome Following Three Randomized Controlled Trials of Choline in Fetal Alcohol Spectrum Disorder (FASD)","authors":"Jeffrey R. Wozniak,&nbsp;Judith K. Eckerle,&nbsp;Blake A. Gimbel,&nbsp;Abigail M. Ernst,&nbsp;Mary E. Anthony,&nbsp;Kent A. Tuominen,&nbsp;Erik de Water,&nbsp;Alexandra L. Doughty,&nbsp;Steven H. Zeisel,&nbsp;Michael K. Georgieff","doi":"10.1111/acer.70394","DOIUrl":"10.1111/acer.70394","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Fetal alcohol spectrum disorder (FASD) represents a range of neurodevelopmental outcomes from prenatal alcohol exposure for which there are few interventions. Preclinical studies have identified choline as a potential treatment for cognitive deficits in FASD. We previously conducted three randomized controlled trials (RCTs) in children under age 6 and reported on memory benefits following all three trials. Two RCTs compared a fixed 500 mg daily dose to placebo, and the third RCT tested a weight-adjusted choline dose. Here, we report on a longitudinal follow-up 5 years post-study completion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The RCTs included 2.5- to 5.9-year-old children with FASD who received choline (<i>n</i> = 53) or placebo (<i>n</i> = 51). Participants described here (<i>n</i> = 28 choline; <i>n</i> = 30 placebo) were 9.1 years old on average at follow-up. Of these, 9% had fetal alcohol syndrome (FAS), 43% partial FAS (PFAS), and 48% alcohol-related neurodevelopmental disorder (ARND). Parents completed a diagnostic interview and behavior checklists while participants completed assessments of general cognitive ability, executive functioning, and memory.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants who received choline in the initial RCT showed a medium effect size performance advantage (9.1% better) for non-verbal IQ and a medium effect size advantage (11.3% better) for working memory over placebo. Age at enrollment did not explain significant variance in outcome but choline dose was significantly associated with non-verbal IQ and working memory (higher dose contributed to better performance at follow-up). High rates of anxiety disorders and impulse-control disorders were observed. While there were no statistically significant differences in mental health diagnoses for choline versus placebo, there were some differences that neared significance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Very few RCTs have been conducted in FASD, and interventions targeting cognitive functioning are needed. The data reported here suggest that choline supplementation has long-lasting neurodevelopmental benefits, especially in non-verbal IQ and working memory for individuals with FASD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic Risk Profiles and the Manifestations of Alcohol Use Disorder and Related Outcomes","authors":"Genevieve F. Dash,&nbsp;Fazil Aliev,&nbsp;Sally I-Chun Kuo,&nbsp;Andrey Anokhin,&nbsp;Sarah J. Brislin,&nbsp;Kathleen Bucholz,&nbsp;Grace Chan,&nbsp;Maia Choi,&nbsp;Emma C. Johnson,&nbsp;Chella Kamarajan,&nbsp;Samuel Kuperman,&nbsp;Alex P. Miller,&nbsp;John I. Nurnberger,&nbsp;Martin H. Plawecki,&nbsp;Holly E. Poore,&nbsp;John Rice,&nbsp;Leah Wetherill,&nbsp;COGA Collaborators,&nbsp;Danielle M. Dick","doi":"10.1111/acer.70390","DOIUrl":"10.1111/acer.70390","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Research suggests that multiple genetically influenced pathways of risk impact alcohol use disorder (AUD), including externalizing (disinhibition, behavioral undercontrol), internalizing (negative affect, depression), and alcohol-specific (physiological response to alcohol) factors. This study examined the joint effects of genetic influences representing these risk domains on AUD and their influence on comorbid phenotypes among individuals with AUD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants of European-like ancestry from the Collaborative Study on the Genetics of Alcoholism (<i>N</i> = 6883) provided data on lifetime AUD, conduct disorder (CD), antisocial personality disorder (ASPD), major depressive disorder (MDD), alcohol expectancies, sensation seeking, and neuroticism. Polygenic scores (PGS) representing externalizing (EXT), major depressive disorder (MDD), and alcohol-specific (ALC-sp) risk were calculated. First, participants were grouped based on combinations of high versus low (top vs. bottom 30%) EXT, MDD, and ALC-sp PGS (<i>n</i> = 2006), and AUD outcomes were compared across groups. Second, among individuals with AUD, psychopathology, alcohol expectancies, sensation seeking, and neuroticism were compared across those with high versus low EXT (<i>n</i> = 1664), MDD (<i>n</i> = 1620), and ALC-sp (<i>n</i> = 1669) PGS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants with three high PGS and those with high EXT + high ALC-sp PGS had the most severe AUD outcomes. High EXT + high MDD PGS and high MDD + high ALC-sp PGS groups generally did not differ from groups with only one high PGS. Comparisons between groups with only one high PGS were not significant. Among individuals with AUD, high EXT PGS was associated with CD/ASPD, arousal/aggression alcohol expectancies, and relaxation/tension reduction alcohol expectancies; high MDD PGS was associated with MDD and neuroticism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Quantity and type of genetic risk are important for AUD outcomes. EXT plays an outsized role in AUD, particularly in the presence of other high PGS, and may potentiate alcohol expectancies that reinforce harmful patterns of use. Findings elucidate the role of multiple pathways of genetic risk for AUD and how they impact comorbid phenotypes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marital Status History and Alcohol Use and Problems Across the Lifespan","authors":"Fanghong Dong,&nbsp;Christina Garasky,&nbsp;Jessica Salvatore,&nbsp;Sally Kuo,&nbsp;Grace Chan,&nbsp;Howard J. Edenberg,&nbsp;Chella Kamarajan,&nbsp;Martin Henry Plawecki,&nbsp;Victor Hesselbrock,&nbsp;Jacquelyn L. Meyers,&nbsp;Danielle M. Dick,&nbsp;Elliot Nelson,&nbsp;Emma Johnson,&nbsp;Arpana Agrawal,&nbsp;Kathleen Bucholz,&nbsp;Vivia McCutcheon","doi":"10.1111/acer.70378","DOIUrl":"10.1111/acer.70378","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Marital transitions and stability are key social determinants of alcohol use, yet their impact across different life stages remains underexplored. This study utilizes a lifespan-oriented approach to examine longitudinal associations between marital status and alcohol consumption and problems and to investigate underlying sex differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Longitudinal data from two components (early mid-life and later-life) of the Collaborative Study on the Genetics of Alcoholism (COGA) were included, with participants averaging 33 (early mid-life) and 62 (later-life) years of age at their last interview. Participants were categorized into distinct groups based on their marital history across assessment waves: persistently married (reference), never married, divorced/separated, widowed, and three transition groups (into marriage, out of marriage, and mixed transitions). Alcohol use measures included past 12-month alcohol symptom counts, past 6-month typical drinks per week, and past 6-month maximum drinks consumed in 24 h. Generalized linear mixed models estimated cohort-specific risks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Across both cohorts, alcohol consumption declined with age, while AUD symptom counts significantly increased (<i>p</i> &lt; 0.001). In the later-life sample, never married individuals exhibited the highest likelihood of AUD symptoms (IRR = 3.82, <i>p</i> &lt; 0.001). A significant sex interaction indicated widowhood was associated with a threefold increase in AUD symptoms (IRR = 3.46, <i>p</i> = 0.003), whereas widowhood was relatively protective among women (reference group). In the early mid-life sample, transitioning out of marriage emerged as a primary correlate of symptom escalation (IRR = 2.13, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Marital stability buffers against AUD problems across the lifespan. However, the risks associated with marital instability are highly specific: marital exit poses a critical threat in early mid-life, while widowhood represents a profound vulnerability for older men. Interventions should be tailored with attention to life stage and sex-specific risks to mitigate alcohol-related harm during marital transitions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Social Contexts of Alcohol and Cannabis Use and Perceived Descriptive Norms in Sexual Minority Women and Gender Diverse Individuals Assigned Female at Birth","authors":"Haley A. Edison,&nbsp;Christina Dyar","doi":"10.1111/acer.70422","DOIUrl":"10.1111/acer.70422","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Existing literature primarily uses minority stress theory as an explanation for disparities in alcohol and cannabis use affecting sexual and gender minority (SGM) populations. Far less research has examined the roles of other factors, such as social norms. Elevated perceived descriptive norms for similar peer groups have been linked to individuals' increased alcohol and cannabis use, making descriptive norms a potential key risk factor for problematic alcohol and cannabis use among SGM groups. No studies to date have examined the development of descriptive norms in SGM people. The current study aimed to further the understanding of the development of descriptive norms for alcohol and cannabis use in sexual minority women and gender diverse (SMWGD) individuals assigned female at birth by examining cross-sectional and prospective associations between frequency of alcohol and cannabis use with other SGM people and perceived descriptive alcohol and cannabis norms using regression models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used data from a baseline survey, follow-up survey, and a 30-day EMA period from a longitudinal study of 409 SMWGD individuals ages 18–25 years old.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Drinking more frequently with SGM individuals during the EMA period was cross-sectionally associated with higher perceived frequency of drinking among SMWGD individuals at baseline and prospectively predicted increases in the perceived frequency of drinking among SMWGD individuals from baseline to follow-up. None of the concurrent or prospective associations between frequency of using cannabis with SGM individuals during the EMA period and descriptive norms for cannabis use among SMWGD individuals were significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings provide important information about the development of descriptive norms for alcohol and cannabis use in SMWGD individuals, which can be used to inform earlier norms-based substance use interventions in this population. Predicting elevated descriptive norms in this population also provides novel intervention targets for norms-based interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Transdermal Alcohol Concentration Features Derived From a Wrist-Worn Sensor and Subjective Response to Alcohol Assessed via Ecological Momentary Assessment","authors":"Elizabeth Chevalier,&nbsp;Shreya Narla,&nbsp;Yan Wang,&nbsp;Stephanie M. Gorka,&nbsp;Robert F. Leeman,&nbsp;Jessica Weafer","doi":"10.1111/acer.70423","DOIUrl":"10.1111/acer.70423","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>There is a growing interest in the use of reliable, accurate, and user-friendly wearable biosensors to measure alcohol consumption in naturalistic environments. Growing evidence has shown that the BACtrack Skyn, a wrist-worn alcohol biosensor, can reliably measure alcohol consumption in these settings. However, little is known regarding the utility of Skyn features in predicting real-time subjective response to alcohol. This study examined associations between Skyn transdermal alcohol concentration (TAC) features and both self-reported alcohol consumption and subjective response assessed via ecological momentary assessment (EMA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Moderate drinkers (<i>n</i> = 50, ages 21–25) completed EMA assessments and wore the Skyn biosensor for 11 consecutive days. Participants completed post-drink questionnaires after each drink and completed multiple EMA surveys on non-drinking nights as well. Measures included the brief biphasic alcohol effects scale (B-BAES) to assess stimulation and sedation and visual analog scales (VAS) to assess mood, craving, and intoxication. Total drinks were reported in a morning questionnaire. Skyn data were processed using the Skyn Data Manager (SDM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Correlational analyses showed that all TAC measures were positively associated with self-reported drinks (<i>p</i>s &lt; 0.001). Linear mixed effects models showed that peak TAC and TAC-AUC predicted stimulation, positive mood, craving, and intoxication (<i>p</i>s &lt; 0.05), and TAC rate of rise predicted stimulation, craving, and intoxication (<i>p</i>s &lt; 0.001). Peak TAC interacted with weekend days to predict intoxication, such that peak TAC was a stronger predictor of intoxication on weekends compared to weekdays.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These results support the reliability, validity, and utility of the Skyn device in naturalistic studies as well as the use of the SDM as an efficient and reliable method for processing Skyn data. The findings encourage the use of the Skyn in future studies to examine individual differences in associations between objective measures of alcohol consumption and subjective response in naturalistic environments.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Technology to Enhance Identification of Subtle Facial Dysmorphisms: A Critical Milestone in Diagnosis","authors":"Suzy Davies,&nbsp;Jessie R. Maxwell","doi":"10.1111/acer.70429","DOIUrl":"https://doi.org/10.1111/acer.70429","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderate Prenatal Alcohol Exposure Disrupts Brain Redox Homeostasis and the Activity of Tyrosine Phosphatase STEP in Adult Offspring","authors":"Anindita Bhattacharjee,&nbsp;Sathyanarayanan Rajagopal,&nbsp;Seong Won Choi,&nbsp;John Weaver,&nbsp;Ke Jian Liu,&nbsp;Ranjana Poddar,&nbsp;Kevin K. Caldwell,&nbsp;C. Fernando Valenzuela,&nbsp;Surojit Paul","doi":"10.1111/acer.70421","DOIUrl":"https://doi.org/10.1111/acer.70421","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite public health efforts, prenatal alcohol exposure (PAE) remains a significant concern. Its effects on offspring vary depending on the amount and frequency of drinking, and the risk of Fetal Alcohol Spectrum Disorders (FASDs) increases with heavy or binge drinking. In contrast, the long-term consequences of moderate PAE remain unclear. Although previous studies indicate that moderate PAE may have a limited impact on neurodevelopment, its ability to induce persistent cerebrovascular dysfunction may promote chronic low-level oxidative stress in the brain. Therefore, it is important to determine whether moderate PAE can trigger long-lasting impairments in brain function that persist into adulthood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The current study investigated the effect of moderate PAE on the brain's redox environment in adult (4–6 months) and middle-aged (12–14 months) offspring. Electron paramagnetic resonance (EPR) spectroscopy was used to noninvasively measure thiol levels in the brain. Biochemical assays measured levels of reduced and total glutathione, the primary thiol and major antioxidant in the brain. To determine the functional consequences of altered redox status, the study examined the dimerization status and enzymatic activity of the redox-sensitive and neuron-specific tyrosine phosphatase STEP (STriatal Enriched Phosphatase), a key regulator of synaptic signaling and neuroprotection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The findings demonstrate that moderate PAE significantly reduces total thiol content and glutathione levels in adult male PAE offspring. This redox imbalance is accompanied by enhanced STEP dimerization and a concomitant reduction in STEP phosphatase activity. Notably, the redox imbalance and STEP dysfunction persisted into aging in male PAE offspring.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings demonstrate that moderate PAE leads to long-lasting alterations in the brain's redox homeostasis and compromises STEP function in male offspring. Such persistent dysfunction of the redox-sensitive neuroprotectant STEP may increase the vulnerability of male PAE offspring to neurological disorders later in life. Future studies would examine sex- and age-related interactions in PAE offspring.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily-Level Drinking Motives as Predictors of Transdermal Alcohol Concentration and Alcohol-Induced Blackouts Among Young Adults","authors":"Shannon D. Glenn,&nbsp;Michael A. Russell,&nbsp;Robert J. Turrisi,&nbsp;Veronica L. Richards","doi":"10.1111/acer.70426","DOIUrl":"https://doi.org/10.1111/acer.70426","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol use is necessary—but not sufficient—for understanding why individuals experience an alcohol-induced blackout (AIB). Drinking motives are one of the most proximal risk factors for alcohol use. This study conducts a comprehensive within-person examination of AIBs predicted by prospective daily reports of drinking motives and alcohol use measured using a transdermal alcohol concentration (TAC) biosensor.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants were young adults who engaged in risky drinking and experienced at least 1 AIB in the past 3-months (<i>N =</i> 169, <i>M</i>_<i>age</i> = 20.8, 53% female, 87% White, 10% Hispanic). They wore TAC biosensors and completed twice daily surveys about drinking motives and AIBs over six social weekends (i.e., Thursday–Sunday). TAC drinking features (peak, rise rate, and rise duration) were extracted from TAC data for each day. Two-level multilevel structural equation models were conducted to examine the associations between drinking motives, latent intoxication estimated from TAC features, and AIBs. Aim 1 examined separate models for each motive (enhancement, social, coping, conformity). Aim 2 examined a single model with each motive adjusting for the others.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In Aim 1, on days when participants reported higher enhancement, social, coping, and conformity motives, the associated increase in TAC intoxication was associated with increased odds of experiencing an AIB. In Aim 2, when all motives were entered into a single model, only social motives resulted in increased TAC, which subsequently increased the odds of an AIB occurring.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Findings demonstrate that days when an individual reports above average drinking motives relative to their own average, they are at increased risk of engaging in riskier drinking, which may result in subsequent AIBs. These findings suggest that daily changes in drinking motives may be an important intervention pathway for preventing risky drinking and subsequent AIBs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149099337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}