Alcohol (Hanover, York County, Pa.)最新文献

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Santa Claus, the Tooth Fairy, and purported lifetime nondrinkers: Ramifications for observational evidence about alcohol and health. 圣诞老人、牙仙和所谓的终生不饮酒者:对酒精与健康观察证据的影响。
IF 3
Alcohol (Hanover, York County, Pa.) Pub Date : 2024-11-05 DOI: 10.1111/acer.15478
Timothy S Naimi, Tanya Chikritzhs
{"title":"Santa Claus, the Tooth Fairy, and purported lifetime nondrinkers: Ramifications for observational evidence about alcohol and health.","authors":"Timothy S Naimi, Tanya Chikritzhs","doi":"10.1111/acer.15478","DOIUrl":"https://doi.org/10.1111/acer.15478","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Links between adolescent binge drinking and midlife alcohol use behaviors by age, sex, and race/ethnicity. 按年龄、性别和种族/民族分列的青少年暴饮与中年酒精使用行为之间的联系。
IF 3
Alcohol (Hanover, York County, Pa.) Pub Date : 2024-11-01 Epub Date: 2024-10-27 DOI: 10.1111/acer.15435
Megan E Patrick, Sarah J Peterson, Yuk C Pang, Yvonne M Terry-McElrath
{"title":"Links between adolescent binge drinking and midlife alcohol use behaviors by age, sex, and race/ethnicity.","authors":"Megan E Patrick, Sarah J Peterson, Yuk C Pang, Yvonne M Terry-McElrath","doi":"10.1111/acer.15435","DOIUrl":"10.1111/acer.15435","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use is increasing among adults in midlife (i.e., ages 35-60), but few studies examine specific alcohol use behaviors in this age group. We examined measures of typical drinks, maximum drinks, binge drinking, and high-intensity drinking by age, sex, and race/ethnicity among midlife adults, as well as the prospective association between age 18 binge drinking and midlife behaviors.</p><p><strong>Methods: </strong>Data from 5180 respondents participating in the national Monitoring the Future Panel study who were aged 35-60 in 2022 (followed since they were in 12th grade in 1980-2005) were used to estimate past 30-day midlife drinking behaviors (i.e., typical drinks, maximum drinks, binge, and high-intensity drinking) by age group, sex, and race/ethnicity. Associations between age 18 binge drinking status and midlife drinking outcomes were examined, as well as moderation by sociodemographic characteristics.</p><p><strong>Results: </strong>Across ages 35-60, the mean typical number of drinks on drinking days within the past month ranged from 1.4 to 1.8; the mean maximum drinks ranged from 2.3 to 3.2. Past-month binge and high-intensity drinking prevalence ranged from 19.1% to 31.2% and 3.6% to 8.1%, respectively. Estimates of drinking behaviors were generally higher among respondents aged 35-40 (vs. older age groups), males (vs. females), those identifying as White (vs. other racial/ethnic groups), and those who reported age 18 binge drinking (vs. not). Adolescent binge drinking was a stronger predictor of high-intensity drinking among females than males and of typical and maximum drinks among older (age 60) than younger (age 35) respondents.</p><p><strong>Conclusion: </strong>Binge and high-intensity drinking were reported by a meaningful percentage of the US midlife adults. Binge drinking in adolescence was a predictor of subsequent alcohol-related risks. These long-term connections were especially strong among females. Age 18 binge drinking was a stronger predictor of high-intensity drinking at age 60 than earlier in midlife, underscoring that adolescent binge drinking is a key indicator of risk across the lifespan.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical characteristics of seizure recurrence and epilepsy development in patients with alcohol-related seizures. 酒精相关性癫痫发作患者癫痫复发和癫痫发展的临床特征。
IF 3
Alcohol (Hanover, York County, Pa.) Pub Date : 2024-11-01 Epub Date: 2024-09-27 DOI: 10.1111/acer.15449
Min Young Chun, Hyungmi An, Hye Ah Lee, Sungeun Hwang, Seungwon Chung, Na-Young Kim, Hyang Woon Lee
{"title":"Clinical characteristics of seizure recurrence and epilepsy development in patients with alcohol-related seizures.","authors":"Min Young Chun, Hyungmi An, Hye Ah Lee, Sungeun Hwang, Seungwon Chung, Na-Young Kim, Hyang Woon Lee","doi":"10.1111/acer.15449","DOIUrl":"10.1111/acer.15449","url":null,"abstract":"<p><strong>Background: </strong>Alcohol withdrawal is widely recognized as a trigger for acute symptomatic seizures among individuals with chronic alcohol consumption. While most alcohol withdrawal seizures occur shortly after cessation, chronic alcohol consumption can be associated with the development of epilepsy, necessitating anti-epileptic drug (AED) therapy. This study aimed to investigate the clinical characteristics, seizure recurrence, and epilepsy development in patients with alcohol-related seizures and to identify prognostic factors for epilepsy.</p><p><strong>Methods: </strong>In a retrospective analysis at Ewha Womans University Mokdong Hospital, 206 patients with alcohol-related seizures were examined and 15 were excluded due to preexisting epilepsy. Demographic and clinical data, including alcohol withdrawal duration, seizure recurrence, types, and comorbidities, were investigated. Logistic regression models were used to analyze the risk factors for seizure recurrence and epilepsy development. The performance of the final models was evaluated based on the area under the receiver operating characteristic curve (AUC) and validated using calibration plots and leave-one-out cross-validation.</p><p><strong>Results: </strong>Of the 191 patients (146 males; mean age 48.3 ± 12.1 years) with alcohol-related seizures, 99 patients (51.8%) experienced seizure recurrence and 79 patients (41.4%) developed epilepsy. Factors associated with seizure recurrence included alcohol consumption levels, occurrence of focal impaired awareness seizure, anxiety, and headache. The number of recurrent seizures, semiology, status epilepticus, electroencephalogram findings, and brain imaging findings was associated with epilepsy development. The predictive models showed strong diagnostic performance, with AUCs of 0.833 for seizure recurrence and 0.939 for epilepsy development.</p><p><strong>Conclusion: </strong>High alcohol consumption and specific clinical and diagnostic features are significant predictors of seizure recurrence and the development of epilepsy among patients with alcohol-related seizures. These findings underscore the importance of early identification and intervention to prevent seizure recurrence and the onset of epilepsy, emphasizing the importance of AED treatment in managing these conditions.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevations in interleukin-8 levels in individuals with alcohol use disorder and clinical insomnia symptoms. 酒精使用障碍和临床失眠症状患者的白细胞介素-8水平升高。
IF 3
Alcohol (Hanover, York County, Pa.) Pub Date : 2024-11-01 Epub Date: 2024-10-13 DOI: 10.1111/acer.15444
Erica N Grodin, Wave-Ananda Baskerville, Kaitlin R McManus, Michael R Irwin, Lara A Ray
{"title":"Elevations in interleukin-8 levels in individuals with alcohol use disorder and clinical insomnia symptoms.","authors":"Erica N Grodin, Wave-Ananda Baskerville, Kaitlin R McManus, Michael R Irwin, Lara A Ray","doi":"10.1111/acer.15444","DOIUrl":"10.1111/acer.15444","url":null,"abstract":"<p><strong>Background: </strong>Insomnia commonly co-occurs with alcohol use disorder (AUD) and predicts poorer outcomes for those with AUD. Insomnia and AUD are individually associated with increases in systemic inflammation. Insomnia and inflammation both serve as risk factors for relapse in AUD. However, little is known about the relationship between insomnia and systemic inflammation in individuals with AUD. Therefore, the present study examined the relationship between the severity of insomnia symptoms and plasma levels of inflammatory cytokines in a sample of treatment-seeking individuals with an AUD.</p><p><strong>Methods: </strong>This secondary analysis included 101 (61M/40F) individuals with an AUD. Participants were categorized into groups based on their scores on the Insomnia Severity Index: no insomnia (n = 47), subthreshold insomnia (n = 37), and clinical insomnia (n = 17). Participants provided blood samples to measure plasma levels of four peripheral markers of inflammation (IL-6, IL-8, TNF-α, and CRP). Inflammatory marker levels were compared between groups. Interactive effects of sex and AUD severity were examined.</p><p><strong>Results: </strong>There was a significant main effect of insomnia group on log IL-8 levels (F = 6.52, p = 0.002), such that individuals with AUD and clinical insomnia had higher log IL-8 levels compared to both the no insomnia and subthreshold insomnia groups (ps ≤ 0.05). Sex and AUD severity interacted with this relationship, such that men with clinical insomnia and AUD and individuals with severe AUD had higher log IL-8 levels. There were no significant effects of insomnia on IL-6, TNF-α, or CRP levels.</p><p><strong>Conclusion: </strong>The present study identified a specific elevation in IL-8 levels in individuals with an AUD and clinical insomnia that was not identified in other markers of peripheral inflammation (IL-6, TNF-α, CRP). Sex and AUD severity interacted with insomnia symptoms, indicating that those with clinical insomnia and severe AUD or male sex may be the most vulnerable to the inflammatory consequences associated with AUD and clinical insomnia symptoms.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid droplet-associated proteins in alcohol-associated fatty liver disease: A proteomic approach. 酒精相关性脂肪肝中的脂滴相关蛋白:蛋白质组学方法
IF 3
Alcohol (Hanover, York County, Pa.) Pub Date : 2024-11-01 Epub Date: 2024-10-16 DOI: 10.1111/acer.15446
Sathish Kumar Perumal, Le Z Day, Madan Kumar Arumugam, Srinivas Chava, Vikas Kumar, Natalia A Osna, Jon Jacobs, Karuna Rasineni, Kusum K Kharbanda
{"title":"Lipid droplet-associated proteins in alcohol-associated fatty liver disease: A proteomic approach.","authors":"Sathish Kumar Perumal, Le Z Day, Madan Kumar Arumugam, Srinivas Chava, Vikas Kumar, Natalia A Osna, Jon Jacobs, Karuna Rasineni, Kusum K Kharbanda","doi":"10.1111/acer.15446","DOIUrl":"10.1111/acer.15446","url":null,"abstract":"<p><strong>Background: </strong>The earliest manifestation of alcohol-associated liver disease (ALD) is steatosis characterized by deposition of fat in specialized organelles called lipid droplets (LDs). While alcohol administration causes a rise in LD numbers in the hepatocytes, little is known regarding their characteristics that allow their accumulation and size to increase. The aim of the present study is to gain insights into underlying pathophysiological mechanisms by investigating the ethanol-induced changes in hepatic LD proteome as a function of LD size.</p><p><strong>Methods: </strong>Adult male Wistar rats (180-200 g BW) were fed with ethanol liquid diet for 6 weeks. At sacrifice, large-, medium-, and small-sized hepatic LD subpopulations (LD1, LD2, and LD3, respectively) were isolated and subjected to morphological and proteomic analyses.</p><p><strong>Results: </strong>Morphological analysis of LD1-LD3 fractions of ethanol-fed rats clearly demonstrated that LD1 contained larger LDs compared with LD2 and LD3 fractions. Our preliminary results from principal component analysis showed that the proteome of different-sized hepatic LD fractions was distinctly different. Proteomic data analysis identified over 2000 proteins in each LD fraction with significant alterations in protein abundance among the three LD fractions. Among the altered proteins, several were related to fat metabolism, including synthesis, incorporation of fatty acid, and lipolysis. Ingenuity pathway analysis revealed increased fatty acid synthesis, fatty acid incorporation, LD fusion, and reduced lipolysis in LD1 compared to LD3. Overall, the proteomic findings indicate that the increased level of protein that facilitates fusion of LDs combined with an increased association of negative regulators of lipolysis dictates the generation of large-sized LDs during the development of alcohol-associated hepatic steatosis.</p><p><strong>Conclusion: </strong>Several significantly altered proteins were identified in different-sized LDs isolated from livers of ethanol-fed rats. Ethanol-induced increases in specific proteins that hinder LD lipid metabolism led to the accumulation and persistence of large-sized LDs in the liver.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Voucher-based contingency management to promote treatment engagement in comorbid alcohol use disorder and alcohol-related liver disease: A pilot theory-informed qualitative study with service users. 以代金券为基础的应急管理,促进合并酒精使用障碍和酒精相关肝病患者参与治疗:以服务使用者为对象的试点理论定性研究。
IF 3
Alcohol (Hanover, York County, Pa.) Pub Date : 2024-11-01 Epub Date: 2024-09-26 DOI: 10.1111/acer.15450
Sofia Hemrage, Stephen Parkin, Nicola Kalk, Naina Shah, Paolo Deluca, Colin Drummond
{"title":"Voucher-based contingency management to promote treatment engagement in comorbid alcohol use disorder and alcohol-related liver disease: A pilot theory-informed qualitative study with service users.","authors":"Sofia Hemrage, Stephen Parkin, Nicola Kalk, Naina Shah, Paolo Deluca, Colin Drummond","doi":"10.1111/acer.15450","DOIUrl":"10.1111/acer.15450","url":null,"abstract":"<p><strong>Background: </strong>Effective interventions for the management of alcohol-related liver disease (ARLD) remain a gap in clinical practice, and patients' engagement with alcohol services is suboptimal. Based upon the principles of operant conditioning, contingency management (CM) is a psychosocial intervention th at involves gradual, increasing incentives upon completion of treatment-related goals such as treatment attendance.</p><p><strong>Methods: </strong>A pilot feasibility trial was conducted with 30 adult patients recruited from an inpatient clinical setting. Consecutive sampling was used to recruit patients presenting comorbid alcohol use disorder (AUD) and ARLD. Participants were randomized to integrated liver care (ILC), receiving hepatology and AUD care, or ILC with a voucher-based CM intervention (intervention arm). A longitudinal qualitative approach was adopted to explore anticipated (Stage 1) and experienced acceptability (Stage 2). The Theoretical Framework of Acceptability (TFA) guided semi-structured in-depth interviews and deductive analysis.</p><p><strong>Results: </strong>Thirty participants were enrolled in the pilot trial, and interviews were conducted with 24 participants at Stage 1 and seven at Stage 2. Over half of the cohort (54.2%, n = 13) presented decompensated liver disease, and an average of 179 units of alcohol were consumed per week. Overall positive views toward voucher-based CM were noted, and explanatory data emerged across five TFA domains (intervention coherence, ethicality, self-efficacy, perceived effectiveness, and affective attitude). The core aspects of the voucher-based CM intervention matched participants' preferences and needs. Participants regarded CM as having a symbolic value and strengthening the therapeutic alliance with healthcare providers.</p><p><strong>Conclusion: </strong>The data support the scope of voucher-based CM intervention to promote engagement with treatment services, and its potential to address the gaps in the care continuum in ARLD. The findings are of practical significance for developing person-centered, tailored interventions for this clinical population. The outcomes of this investigation can inform decision-making among stakeholders and healthcare providers and improve health outcomes for this clinical population.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insomnia treatment effects on negative emotionality among veterans in treatment for alcohol use disorder. 失眠治疗对接受酒精使用障碍治疗的退伍军人负面情绪的影响。
IF 3
Alcohol (Hanover, York County, Pa.) Pub Date : 2024-11-01 Epub Date: 2024-10-28 DOI: 10.1111/acer.15436
Mary Beth Miller, Ryan W Carpenter, Melissa Nance, Lindsey K Freeman, Jane Metrik, Brian Borsari, Christina S McCrae, Jennifer E Merrill, Kate B Carey, John E McGeary
{"title":"Insomnia treatment effects on negative emotionality among veterans in treatment for alcohol use disorder.","authors":"Mary Beth Miller, Ryan W Carpenter, Melissa Nance, Lindsey K Freeman, Jane Metrik, Brian Borsari, Christina S McCrae, Jennifer E Merrill, Kate B Carey, John E McGeary","doi":"10.1111/acer.15436","DOIUrl":"10.1111/acer.15436","url":null,"abstract":"<p><strong>Background: </strong>Insomnia symptoms are pervasive and persistent in alcohol use disorder (AUD), though little is known about the mechanisms that underlie this association. We previously found that cognitive behavioral therapy for insomnia (CBT-I) reduced alcohol-related problems among veterans by improving insomnia severity (NCT03806491). In this planned secondary analysis of the same clinical trial data, we tested negative emotionality as one potential mechanism to explain this effect. Specifically, we tested the change in negative emotionality as a mediator of the association between change in insomnia symptoms and alcohol-related outcomes (craving, heavy drinking frequency, and alcohol-related problems).</p><p><strong>Methods: </strong>Participants were 67 veterans in treatment for AUD who also met the criteria for insomnia disorder (91% male, 84% White, average age = 46.3 years). Participants were randomized to five sessions of CBT-I or a single-session sleep hygiene control. Assessments occurred at baseline, immediately posttreatment (~6 weeks after baseline), and at 6-week follow-up. Measures included the Insomnia Severity Index, Penn Alcohol Craving Scale, Timeline Followback, and Short Inventory of Problems. We created a latent negative emotionality indicator based on five validated and reliable measures of negative emotionality.</p><p><strong>Results: </strong>Contrary to hypotheses, CBT-I did not improve negative emotionality relative to sleep hygiene control. However, across both treatment conditions, decreases in insomnia symptoms from baseline to posttreatment were associated with concurrent decreases in negative emotionality, which in turn predicted reductions in alcohol craving and heavy drinking.</p><p><strong>Conclusion: </strong>Negative emotionality may help explain links between insomnia symptoms and alcohol-related outcomes.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal alcohol exposure and health at midlife: Self-reported health outcomes in two cohorts. 产前酒精暴露与中年健康:两个队列中自我报告的健康结果。
IF 3
Alcohol (Hanover, York County, Pa.) Pub Date : 2024-11-01 Epub Date: 2024-10-29 DOI: 10.1111/acer.15441
C D Coles, Z R Shapiro, J A Kable, S A Stoner, G J Ritfeld, T M Grant
{"title":"Prenatal alcohol exposure and health at midlife: Self-reported health outcomes in two cohorts.","authors":"C D Coles, Z R Shapiro, J A Kable, S A Stoner, G J Ritfeld, T M Grant","doi":"10.1111/acer.15441","DOIUrl":"10.1111/acer.15441","url":null,"abstract":"<p><strong>Background: </strong>The Developmental Origins of Health and Disease Hypothesis (DOHaD) suggests prenatal alcohol exposure (PAE) should have implications for adult physical and mental health. Since the health profile of older adults with PAE and diagnoses of fetal alcohol spectrum disorder (FASD) is unknown, the current study evaluates self-reported health problems of midlife adults with and without a history of PAE to describe these outcomes.</p><p><strong>Methods: </strong>Participants (N = 357) recruited from longitudinal cohorts in Atlanta, GA and Seattle, WA completed a health survey assessing a range of physical conditions. Initial analysis compared the frequency of conditions between alcohol-exposed and nonexposed groups. To identify patterns within groups, 10 problem areas were subjected to latent class analysis (LCA). Finally, the direct effect of PAE on health outcomes was evaluated using multilevel modeling, controlling for effects of other factors.</p><p><strong>Results: </strong>Compared with unexposed controls, individuals with PAE reported significantly higher frequencies of problems with hearing, dentition, heart, cancer, gastritis, kidney stones, bladder, diabetes, thyroid, skin, and seizures. LCA found that controls yielded two classes, with 45% reporting sleep and vision problems and 55% reporting sleep, vision, cardiovascular, endocrine, immune, and dental problems. The PAE group yielded three classes, with 13% endorsing few health problems, 43% reporting sleep, vision, immune, and dental problems, and 43% reporting sleep, vision, cardiovascular, urinary, endocrine, skin, immune, dental, and gastrointestinal problems. With multivariate analysis, controlling for other influences, PAE was associated directly with hearing, urinary, dental, and gastrointestinal problems. A similar pattern was found for alcohol-exposed individuals who did and did not meet criteria for fetal alcohol syndrome (FAS).</p><p><strong>Discussion: </strong>Patients affected by alcohol may report greater frequency and range of health adversity. That PAE was only uniquely associated with a limited set of problems suggests that many health outcomes in midlife result from an initial vulnerability potentiated by postnatal stress resulting from other associated factors.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploratory analysis of blood alcohol concentration-related technology use and drinking outcomes among young adults. 对血液酒精浓度相关技术的使用和年轻人饮酒结果的探索性分析。
IF 3
Alcohol (Hanover, York County, Pa.) Pub Date : 2024-11-01 Epub Date: 2024-09-30 DOI: 10.1111/acer.15455
Sayre E Wilson, Hannah A Lavoie, Benjamin L Berey, Tessa Frohe, Bonnie H P Rowland, Liana S E Hone, Robert F Leeman
{"title":"Exploratory analysis of blood alcohol concentration-related technology use and drinking outcomes among young adults.","authors":"Sayre E Wilson, Hannah A Lavoie, Benjamin L Berey, Tessa Frohe, Bonnie H P Rowland, Liana S E Hone, Robert F Leeman","doi":"10.1111/acer.15455","DOIUrl":"10.1111/acer.15455","url":null,"abstract":"<p><strong>Background: </strong>Mobile health (mHealth) technology use may reduce alcohol use and related negative consequences; however, little is known about its efficacy without prompting from researchers or pay-per-use. This exploratory analysis assessed relationships between mHealth technology use frequency and alcohol-use outcomes.</p><p><strong>Methods: </strong>Young adults who drink heavily (N = 97, M<sub>age</sub> = 23, 51% male, 64% non-Hispanic White, M<sub>drinks/week</sub> = 21) had the option to use three mHealth technologies (breathalyzer device/app, blood alcohol content estimator app, drink counting via text message) while drinking for 2 weeks. Relationships between alcohol-related outcomes and any, multiple, and specific mHealth technology use across study days and drinking days were evaluated via bivariate correlations and multiple regressions.</p><p><strong>Results: </strong>Participants used one or more mHealth technologies on approximately 68% of drinking days (33% of field days), with multiple technologies used on 34% of drinking days. Bivariate correlations revealed that a higher percentage of study days with any mHealth technology use was related to higher mean weekly drinks. However, a higher percentage of drinking days with any mHealth technology use was related to lower mean weekly drinks, percent of heavy and high-intensity drinking days, and negative consequences. There were several significant, inverse correlations between alcohol variables and using the mHealth technologies that provided personalized feedback. Multiple regression analyses (holding sex and baseline alcohol variables constant) indicated that a higher percentage of drinking days with any mHealth technology use was related to lower mean weekly drinks and lower percentage of heavy drinking days.</p><p><strong>Conclusions: </strong>Using mHealth technologies to moderate drinking without direct prompting from the research team or per-use incentives was related to less overall alcohol use and heavy drinking. This indicates potential real-world engagement with mHealth apps to assist with in-the-moment drinking. Normalizing mHealth technology use during drinking could help curb the public health crisis around harmful alcohol use in young adult populations.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol hangovers as a predictor of the development of immune-related chronic diseases. 宿醉是免疫相关慢性病发病的预测因素。
IF 3
Alcohol (Hanover, York County, Pa.) Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI: 10.1111/acer.15434
Emina Išerić, Andrew Scholey, Joris C Verster
{"title":"Alcohol hangovers as a predictor of the development of immune-related chronic diseases.","authors":"Emina Išerić, Andrew Scholey, Joris C Verster","doi":"10.1111/acer.15434","DOIUrl":"10.1111/acer.15434","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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