Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Patient perspectives on medications for alcohol use disorder: A systematic scoping review.","authors":"Devin C Tomlinson, Autumn Rae Florimbio, Carol A Lee, Mark A Ilgen, Lewei A Lin, Lara N Coughlin","doi":"10.1111/acer.70022","DOIUrl":"https://doi.org/10.1111/acer.70022","url":null,"abstract":"<p><p>Front-line treatments for alcohol use disorder (AUD) include psychotherapy and medication, and both treatments are underused. However, utilization rates of medications for alcohol use disorder (MAUD) are particularly low. The goal of the present scoping review is to characterize patient perspectives about MAUD to identify barriers to MAUD and potential areas of future work to increase access, initiation, and retention on MAUD. Searches of titles and abstracts were conducted on PubMed, EMBASE, PsycINFO, and CINAHL until March 2024 with patient perspective-, MAUD-, and alcohol-related keywords. Articles were assessed for eligibility and included in the present review if they examined adult patients' perspectives of MAUD. Fourteen studies were included in the review. The majority of patient populations assessed were individuals with AUD, and most studies evaluated MAUD in general (n = 7) or specific medications (i.e., naltrexone, n = 5; disulfiram, n = 2; acamprosate, n = 1). Important themes related to patient-perceived barriers to MAUD were identified, including a lack of awareness and misunderstanding about the effectiveness and effects of MAUD, apprehensiveness or experience with side effects, and perceived stigma of MAUD. Future work incorporating patient perspectives of MAUD into interventions and strategies may help improve MAUD uptake, including person-centered discussions factoring in unique patient perspectives about MAUD to increase patient MAUD knowledge and reduce MAUD stigma.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying family environment profiles in families of children with prenatal alcohol exposure.","authors":"Riley J Felicicchia, Matthew T Hyland, Scott C Roesch, Sarah N Mattson","doi":"10.1111/acer.70016","DOIUrl":"https://doi.org/10.1111/acer.70016","url":null,"abstract":"<p><strong>Background: </strong>Individuals with prenatal alcohol exposure (PAE) may face unique family environments that potentially influence adaptive functioning and behavioral challenges. This study aimed to identify profiles of families of children with PAE based on family characteristics, including cohesion, conflict, and organization, and to examine the relationship between family environment profiles and child outcomes.</p><p><strong>Methods: </strong>Data were collected from caregivers of 283 youth (5-17 years) with histories of PAE. Caregivers completed several questionnaires, including the Child Behavior Checklist (CBCL), Vineland Adaptive Behavior Scales (VABS), and Family Environment Scale (FES). Latent profile analysis (LPA) was used to identify profiles in the family environment using three subscales from the FES (Cohesion, Conflict, and Organization). Model fit was determined by comparing 1-, 2-, 3-, 4-, and 5-profile solutions. One-way ANCOVA follow-up tests were conducted to explore differences in adaptive and behavioral functioning across family environment profiles.</p><p><strong>Results: </strong>The 4-profile solution was considered the best fit for the data. Interpretation of conditional response probabilities indicated that Profile 1 was defined by low cohesion; Profile 2 was defined by low organization; Profile 3 was defined as high cohesion and organization; and Profile 4 was defined as high conflict. After controlling for race, sex, age, and ethnicity, there were significant profile differences on the Internalizing, Externalizing, and Total Problem Behavior scales of the CBCL. There were no significant differences in adaptive functioning across profiles.</p><p><strong>Conclusions: </strong>The results of this study highlight the importance of the family environment in understanding the strengths and challenges experienced by children with PAE. Four unique profiles of family environments emerged in families of children with PAE. The high-conflict profile was associated with increased behavioral problems in children. These findings can be used to support families of children with PAE and to identify treatment targets for interventions for children with PAE and their caregivers.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic stress-enhanced ethanol drinking: Sex, but not stress responsivity, alters sensitivity to the effects of a CRF-R1 antagonist and a GPR39 agonist in mice.","authors":"Melinda L Helms, Deborah A Finn, Michelle A Nipper, Andrey E Ryabinin, Rita P Cervera-Juanes","doi":"10.1111/acer.70005","DOIUrl":"https://doi.org/10.1111/acer.70005","url":null,"abstract":"<p><strong>Background: </strong>Predator stress (PS) is used to model trauma leading to post-traumatic stress disorder, and it increases ethanol drinking in a proportion of male and female rodents. The goals of the present studies were to identify male and female mice with prior binge drinking experience that exhibited sensitivity and resilience to PS-enhanced drinking and then to test two target molecules (corticotropin releasing factor receptor 1 [CRF-R1] antagonist NBI-27914 [NBI] and G-protein coupled receptor 39 [GPR39] agonist TC-G 1008 [TC-G]) for their ability to selectively reduce PS-enhanced drinking.</p><p><strong>Methods: </strong>Adult male and female C57BL/6J mice received seven binge ethanol sessions, a period of abstinence, and acclimation to lickometer chambers to examine the effects of NBI or TC-G on stress-associated drinking. Following establishment of stable baseline (BL) drinking and four intermittent PS exposures, mice were classified into \"Sensitive\" and \"Resilient\" subgroups, based on the change in ethanol drinking from BL after PS2-4. Then, mice received injections of vehicle or drug (NBI or TC-G) in a within-subjects design. Control studies examined the effects of NBI or TC-G on binge drinking, locomotor activity, and saccharin intake.</p><p><strong>Results: </strong>NBI and TC-G significantly suppressed binge drinking in male and female mice in the control studies. However, sensitivity to the ability of the compounds to decrease PS-enhanced drinking did not differ between animals in the \"PS-sensitive\" versus \"PS-resilient\" subgroups, and female mice were insensitive to TC-G in the traumatic stress drinking model. Specifically, NBI doses of 5 and 10 mg/kg (males) and 12.5 mg/kg (females) significantly decreased PS-associated drinking in both subgroups. TC-G (7.5 mg/kg) significantly decreased PS-associated drinking in both subgroups of male mice but not in female mice.</p><p><strong>Conclusions: </strong>The present findings suggest that stress sensitivity and subsequent enhanced ethanol drinking in the \"Sensitive\" subgroup may not increase sensitivity to CRF-R1 antagonism or GPR39 agonism.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contingency management to promote treatment engagement in comorbid alcohol use disorder and alcohol-related liver disease: Findings from a pilot randomized controlled trial.","authors":"Sofia Hemrage, Nicola Kalk, Naina Shah, Stephen Parkin, Paolo Deluca, Colin Drummond","doi":"10.1111/acer.70018","DOIUrl":"https://doi.org/10.1111/acer.70018","url":null,"abstract":"<p><strong>Background: </strong>Alcohol-related liver disease (ARLD) is a leading cause of preventable death and health inequalities. Evidence-based interventions for comorbid alcohol use disorder (AUD) and ARLD remain limited, and only a small proportion of this clinical population engages with treatment. There is a need to improve patient outcomes by bridging this gap through novel, person-centred interventions. Contingency management (CM) is a psychosocial intervention that involves gradual, increasing incentives upon the completion of treatment-related goals, such as treatment attendance. This single-centre, randomized pilot trial of voucher-based CM was conducted to promote treatment engagement in comorbid AUD and ARLD.</p><p><strong>Methods: </strong>Thirty service users were recruited from an inpatient setting, offered integrated liver care (ILC) and allocated to ILC only or ILC + CM. Primary outcomes included feasibility criteria (recruitment, study retention post-randomization, completeness of data and protocol fidelity). Secondary outcome data on engagement, alcohol intake, and liver function were also collected. Data were gathered at baseline, post-ILC, and 12 weeks post-ILC and analyzed through descriptive statistics.</p><p><strong>Results: </strong>The feasibility of the research was subject to challenges inherent to conducting applied health research in a real-world clinical setting. The recruitment and retention rates were 73.20% and 36.70%, respectively. All participants received CM per protocol. An increasing trend in engagement was observed in the ILC + CM compared to ILC only (67% vs. 33%). A trending 76% reduction in alcohol intake and an overall improvement in liver outcomes were observed among participants engaging with the trial, with no significant differences between control and treatment groups.</p><p><strong>Conclusion: </strong>Overall, the CM intervention was feasible to deliver and appears promising in improving outcomes in individuals with comorbid AUD and ARLD. Aspects related to recruitment, study retention post-randomization, and protocol fidelity need to be further adapted before proceeding with a definitive trial.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective responses to simultaneous alcohol and cannabis use relative to alcohol-only use and cannabis-only use: An ecological momentary assessment investigation.","authors":"Sophie G Coelho, Christian S Hendershot, Jeffrey D Wardell","doi":"10.1111/acer.70017","DOIUrl":"https://doi.org/10.1111/acer.70017","url":null,"abstract":"<p><strong>Background: </strong>Few studies have examined subjective responses to simultaneous alcohol and cannabis use in naturalistic settings. The current study used ecological momentary assessment (EMA) to compare subjective responses between simultaneous use and both alcohol-only use and cannabis-only use sessions, while also examining the moderating role of quantities of alcohol and cannabis consumed at both the session and person levels.</p><p><strong>Methods: </strong>Young adults (N = 149, 59.73% women) reporting recent simultaneous use completed three 21-day EMA bursts, spaced 6 months apart. Participants completed a survey each time they initiated a new session of alcohol or cannabis use, along with two hourly follow-up surveys. Surveys assessed alcohol use (quantities), cannabis use (quantities, forms of cannabis), and current acute subjective responses.</p><p><strong>Results: </strong>At the session level, simultaneous use (vs. alcohol-only use) was associated with greater peak sedation and intoxication, with the latter association strengthened during sessions involving relatively lighter drinking. Simultaneous use sessions also involved greater peak liking ratings relative to alcohol-only use sessions, though only among participants who reported relatively lower average alcohol consumption. In addition, relative to cannabis-only use sessions, simultaneous use sessions were associated with greater peak energized and liking ratings, with the former association strengthened during sessions involving relatively heavier cannabis concentrate use. Simultaneous use sessions also involved lower peak sedated and anxious ratings relative to cannabis-only use sessions, though only among participants who reported relatively lighter average cannabis consumption.</p><p><strong>Conclusions: </strong>Overall, simultaneous use was experienced as more impairing (i.e., greater intoxication and sedation) than alcohol-only use and as more reinforcing (i.e., greater stimulation and liking) than cannabis-only use. Some differences in subjective responses between simultaneous use and single-substance use sessions depended on session-level or person-level consumption amounts, which may inform tailored interventions for simultaneous use.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Species differences in comorbid alcohol use disorder and major depressive disorder: A narrative review.","authors":"Garrett A Winkler, Nicholas J Grahame","doi":"10.1111/acer.70015","DOIUrl":"https://doi.org/10.1111/acer.70015","url":null,"abstract":"<p><p>Alcohol use disorder (AUD) and major depressive disorder (MDD) are often comorbid, and it is estimated that between 15 % to 33% of people dependent on alcohol have an MDD diagnosis. Mood-related symptoms are also common in humans during acute withdrawal, but by most accounts, symptoms abate after 2-4 weeks of alcohol abstinence. Preclinical studies, important for understanding the etiology and finding treatments for this comorbidity, also find depression-like and anxiety-like phenotypes in early abstinence along with protracted negative affect detectable past 2 weeks postcessation. In this narrative review, we focus on the translational divergence of AUD and MDD comorbidity with a focus on the time line mismatch between species in concurrent AUD + MDD and MDD following AUD. We also highlight the preclinical success and clinical failure of classic antidepressants for AUD and the relative absence of withdrawal and negative affect in high-drinking selected lines of mice and rats. We suggest sources of these discrepancies, including discussion of relief/reward-driven drinking subpopulations and future directions for the field.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant caffeine increases voluntary alcohol consumption in male, but not female, adolescent C57BL/6J mice.","authors":"Amarpreet Kaur, Anna G Johnston, Jaytee Wesolowski, Jennifer N Berry","doi":"10.1111/acer.70023","DOIUrl":"https://doi.org/10.1111/acer.70023","url":null,"abstract":"<p><strong>Background: </strong>The notion that stimulating qualities of energy drinks reduce overall depressant effects of alcohol has resulted in an increase in the popularity of combining energy drinks with alcohol among young adults and teenagers. Alcohol misuse often emerges during or shortly after vulnerable adolescent years. Even though energy drinks are frequently advertised to and enjoyed by adolescents, there are limited investigations on the neurobehavioral effects of combining caffeine with alcohol during adolescence. This study sought to examine the impact of exposing C57BL/6J adolescent mice to concurrent alcohol and caffeine.</p><p><strong>Methods: </strong>In the current study, adolescent (n = 98, 50 males and 48 females) C57BL/6J mice were given access to two bottles using an intermittent access (IA) two-bottle choice drinking paradigm for a total of 4 weeks. The experimental bottle contained either caffeine (0.015% w/v), alcohol (10% v/v), or a combination of alcohol + caffeine at the aforementioned concentrations. Adolescent male and female mice were given free access to the substance(s) for 24 h, after which the experimental bottle was taken away for another 24 h.</p><p><strong>Results: </strong>Male adolescent mice consumed significantly more alcohol when combined with caffeine compared to male adolescent mice that had access to alcohol alone. Further, this trend was shown only in male adolescent mice and not in female adolescent mice, as females did not show any differences in alcohol consumption regardless of whether there was caffeine in the mixture. Ten days following the final removal of alcohol and/or caffeine bottles, mice were given a secondary bottle containing alcohol (10%) for 24 h. Male mice previously exposed to alcohol + caffeine consumed a significantly higher quantity of alcohol during the 24-h challenge period.</p><p><strong>Conclusions: </strong>These data suggest that adolescent males may be more vulnerable to consuming higher amounts of alcohol when combined with caffeinated beverages.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of at-risk alcohol use on nighttime blood pressure, urinary catecholamines, and sleep quality in midlife adults.","authors":"Keng-Yu Chang, Tabitha Haun, Zhaoli Liu, Alfredo Gil, Ziba Taherzadeh, Paul J Fadel, Shane A Phillips, Mariann R Piano, Chueh-Lung Hwang","doi":"10.1111/acer.70021","DOIUrl":"https://doi.org/10.1111/acer.70021","url":null,"abstract":"<p><strong>Background: </strong>The association between alcohol and hypertension has been predominantly based on office blood pressure (BP) measurements. However, little is known about the effect of alcohol use on nighttime BP and the underlying mechanisms. The purpose of this study was to investigate the effects of at-risk alcohol use on nighttime BP, urinary catecholamines, and sleep quality in midlife adults.</p><p><strong>Methods: </strong>A total of 32 midlife men and 30 postmenopausal women, free of major clinical diseases and nonsmokers (age: 58 ± 4; mean ± SD), were included. Among all participants, 22 were currently taking antihypertensive medications. At-risk drinkers were defined as those who had a dried blood spot phosphatidylethanol level ≥20 ng/mL. All participants completed 24-h ambulatory BP monitoring and urine collection to determine nighttime (or asleep) BP and nighttime urinary catecholamine levels. Sleep quality was determined by using the Pittsburgh Sleep Quality Index.</p><p><strong>Results: </strong>In midlife adults free of antihypertensive medications, at-risk drinkers had a higher nighttime systolic (118 ± 14 vs. 107 ± 14 mmHg, p = 0.02) and diastolic BP (70 ± 9 vs. 62 ± 9 mmHg, p = 0.003) than low-risk drinkers with no between-group differences in sleep quality component scores (p ≥ 0.14). In midlife adults taking antihypertensive medications, no difference in nighttime BP was found between at-risk drinkers and low-risk drinkers (p ≥ 0.68), with a higher score for the \"use of sleeping medication\" component in high-risk drinkers (p = 0.02). Regardless of antihypertensive medication use, no difference between at-risk drinkers and low-risk drinkers was found in nighttime urinary catecholamine levels (p ≥ 0.19).</p><p><strong>Conclusions: </strong>Our findings suggest that in midlife adults free of antihypertensive medication use, at-risk alcohol use is associated with an increase in nighttime BP, and the increase in nighttime BP may be mediated by mechanisms other than increased catecholamines and poor sleep quality.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of graded alcohol use on atherogenic lipid profiles among Latinos with underlying chronic liver disease.","authors":"Shyam Patel, Laura Bull, Kian Salimi, Amy M Shui, Kevin Siao, Bokun Yang, Jacquelyn J Maher, Mandana Khalili","doi":"10.1111/acer.70010","DOIUrl":"https://doi.org/10.1111/acer.70010","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use and hepatitis C virus (HCV) often coexist and are associated with cardiovascular disease. One of the underlying drivers is dyslipidemia. We assessed lipid and lipoprotein levels and the relationship between alcohol use and atherogenic lipid profiles, specifically small dense low-density lipoprotein cholesterol (sdLDL-C), in Latinos with and without HCV.</p><p><strong>Methods: </strong>From June 1, 2002, to January 1, 2016, 150 Latino adults underwent demographic, clinical, metabolic, lipid/lipoprotein, and genetic evaluations. Linear regression (adjusted for age, sex, and recent alcohol use) assessed factors associated with sdLDL-C.</p><p><strong>Results: </strong>Participant characteristics were as follows: median age 44 years, 64% male, 39% HCV+, and alcohol use in the last 12 months was 19% heavy and 47% moderate. Ancestries were as follows: 52% European, 40% Native American (NA), and 4.3% African. 29% had non-CC PNPLA3, 89% non-CC TM6SF2, and 73% non-CC IL-28b genotypes. High-density lipoprotein (HDL) cholesterol, HDL-3, apolipoprotein A-1, and lipoprotein-associated phospholipase A2 levels differed by alcohol use groups (p < 0.05). On multivariable analysis, female sex (est. -6.08, p < 0.001), HCV+ status (est. -8.49, p < 0.001), and heavy alcohol use (vs. none) (est. -4.32, p = 0.03) were associated with lower, while NA ancestry (est. 0.92; p = 0.01) and adipose tissue insulin resistance (est. 3.30, p < 0.001) were associated with higher sdLDL-C levels. The positive association between NA ancestry and sdLDL-C was dampened by the presence of a non-CC IL28b genotype (interaction est. -1.95, p = 0.01).</p><p><strong>Conclusions: </strong>In this Latino cohort, ancestry and metabolic dysfunction, independent of alcohol use and HCV, were associated with atherogenic risk. In addition to HCV treatment in this population, cardiometabolic health should be optimized.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethanol causes rapid decreases in the hepatic retinoid levels shaping the early steps of alcohol-associated liver disease.","authors":"Xiao-Han Tang, Glen Pesola, Qiuying Chen, Dawson Miller, Laura E Nagy, Megan R McMullen, Robert E Schwartz, Sergey Tsoy, Christine Lim, Shireen Chikara, Steven S Gross, Steven E Trasino, Lorraine J Gudas, Marta Melis","doi":"10.1111/acer.70011","DOIUrl":"https://doi.org/10.1111/acer.70011","url":null,"abstract":"<p><strong>Background: </strong>Chronic alcohol drinking causes hepatic vitamin A (retinoids and derivatives) decreases, which correlate with the progression and severity of alcohol-associated liver disease (ALD). However, the effects of short-term ethanol (EtOH) intake on liver retinoids and ALD are still undefined.</p><p><strong>Methods: </strong>Using high-performance liquid chromatography and high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC, HPLC-MS/MS), and molecular biology techniques in mice and cultured human hepatocytes, we investigated the temporal EtOH effects on retinoids and ALD.</p><p><strong>Results: </strong>In female and male mice, acute EtOH intake caused hepatic retinol (ROL) and retinyl palmitate (RP) decreases within hours, whereas it did not significantly change the retinoic acid (RA) levels, and those of the RA catabolism metabolite, 4-oxo-RA. After EtOH withdrawal, the liver recovered the ROL and RP levels within 48 h, whereas RA and 4-oxo-RA levels remained almost undetectable by this time point. Compared with control diet-fed mice, hepatic ROL and RP levels remained decreased in the 10-day and 3-week-long EtOH treatments, while retinyl oleate and linoleate increased. Interestingly, some of the RA signaling receptors, Rarβ, along with Cyp26a1, revealed dramatic transcript increases during the 10-day-long experiments that attenuated over time (up to 8 weeks), reflecting impaired RA signaling. Our work also showed that primary human hepatocytes serve as a model to better define the role of EtOH in retinoid biology.</p><p><strong>Conclusions: </strong>This work reveals that acute and short-term exposures to EtOH disrupt retinoid homeostasis, identifying key events in the early pathogenesis of ALD.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}