Philip A May, Julie M Hasken, Jason Blankenship, Anna-Susan Marais, J Phillip Gossage, Wendy O Kalberg, Marlene De Vries, Luther K Robinson, David Buckley, Melanie Manning, Charles D H Parry, H Eugene Hoyme, Barbara Tabachnick, Soraya Seedat
{"title":"Does paternal alcohol consumption affect the severity of traits of fetal alcohol spectrum disorders?","authors":"Philip A May, Julie M Hasken, Jason Blankenship, Anna-Susan Marais, J Phillip Gossage, Wendy O Kalberg, Marlene De Vries, Luther K Robinson, David Buckley, Melanie Manning, Charles D H Parry, H Eugene Hoyme, Barbara Tabachnick, Soraya Seedat","doi":"10.1111/acer.70105","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Animal models suggest that paternal alcohol consumption may influence offspring traits, yet few human studies exist.</p><p><strong>Methods: </strong>Data from population-based studies of fetal alcohol spectrum disorders (FASD) among first-grade students provided case-control data to explore traits of fathers of children with: FASD, alcohol exposure, and unexposed controls.</p><p><strong>Results: </strong>Most males in this population drank, but more fathers of children with FASD drank during pregnancy ( <math> <semantics> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> <annotation>$$ \\overline{x} $$</annotation></semantics> </math> = 73.2%) than fathers of controls ( <math> <semantics> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> <annotation>$$ \\overline{x} $$</annotation></semantics> </math> = 63.4%). Among drinkers, fathers of children with FASD: (a) consumed more drinks per occasion than controls ( <math> <semantics> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> <annotation>$$ \\overline{x} $$</annotation></semantics> </math> = 11.5 vs. 9.7 for maternally exposed controls and 8.1 for maternally unexposed controls), (b) drank more frequently and binged, and (c) were reported to have had a drinking problem ( <math> <semantics> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> <annotation>$$ \\overline{x} $$</annotation></semantics> </math> = 27.8% vs. <math> <semantics> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> <annotation>$$ \\overline{x} $$</annotation></semantics> </math> = 18.8%). Partial correlations, controlling for maternal average drinks per drinking day (DDD) by trimester and maternal tobacco use, indicated a significant, negative association between paternal heavy/binge drinking (≥5) and child outcomes resulting in a significant reduction in child height, head circumference, and verbal IQ. Categorical analysis of combined levels of maternal and paternal drinking indicated a significant mean reduction in child height, head circumference, and verbal IQ centile, and a significant increase in total dysmorphology score, did not occur without maternal drinking. Combined paternal and maternal drinking pattern analysis also indicated that paternal drinking was not independently associated with child total dysmorphology scores or neurocognitive outcomes. Models of maternal and paternal drinking were significant, but main and significant effects on total dysmorphology and neurocognitive outcomes were via maternal alcohol consumption. Likewise, paternal alcohol consumption was not independently associated with an FASD diagnosis when controlling for prenatal maternal alcohol and tobacco use.</p><p><strong>Conclusions: </strong>Paternal alcohol consumption was associated with an independent, negative influence on child height, head circumference, and verbal IQ. Maternal drinking, when combined with heavy male drinking, was associated with more severe FASD outcomes.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258960/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alcohol (Hanover, York County, Pa.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/acer.70105","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Animal models suggest that paternal alcohol consumption may influence offspring traits, yet few human studies exist.
Methods: Data from population-based studies of fetal alcohol spectrum disorders (FASD) among first-grade students provided case-control data to explore traits of fathers of children with: FASD, alcohol exposure, and unexposed controls.
Results: Most males in this population drank, but more fathers of children with FASD drank during pregnancy ( = 73.2%) than fathers of controls ( = 63.4%). Among drinkers, fathers of children with FASD: (a) consumed more drinks per occasion than controls ( = 11.5 vs. 9.7 for maternally exposed controls and 8.1 for maternally unexposed controls), (b) drank more frequently and binged, and (c) were reported to have had a drinking problem ( = 27.8% vs. = 18.8%). Partial correlations, controlling for maternal average drinks per drinking day (DDD) by trimester and maternal tobacco use, indicated a significant, negative association between paternal heavy/binge drinking (≥5) and child outcomes resulting in a significant reduction in child height, head circumference, and verbal IQ. Categorical analysis of combined levels of maternal and paternal drinking indicated a significant mean reduction in child height, head circumference, and verbal IQ centile, and a significant increase in total dysmorphology score, did not occur without maternal drinking. Combined paternal and maternal drinking pattern analysis also indicated that paternal drinking was not independently associated with child total dysmorphology scores or neurocognitive outcomes. Models of maternal and paternal drinking were significant, but main and significant effects on total dysmorphology and neurocognitive outcomes were via maternal alcohol consumption. Likewise, paternal alcohol consumption was not independently associated with an FASD diagnosis when controlling for prenatal maternal alcohol and tobacco use.
Conclusions: Paternal alcohol consumption was associated with an independent, negative influence on child height, head circumference, and verbal IQ. Maternal drinking, when combined with heavy male drinking, was associated with more severe FASD outcomes.
背景：动物模型表明父亲饮酒可能会影响后代的性状，但很少有人类研究存在。方法：基于人群的一年级学生胎儿酒精谱系障碍（FASD）研究数据提供了病例对照数据，以探讨FASD、酒精暴露和未暴露对照组儿童父亲的特征。结果：该人群中大多数男性饮酒，但FASD患儿的父亲在怀孕期间饮酒较多（x¯$$ \overline{x} $$ = 73.2）%) than fathers of controls ( x ¯ $$ \overline{x} $$ = 63.4%). Among drinkers, fathers of children with FASD: (a) consumed more drinks per occasion than controls ( x ¯ $$ \overline{x} $$ = 11.5 vs. 9.7 for maternally exposed controls and 8.1 for maternally unexposed controls), (b) drank more frequently and binged, and (c) were reported to have had a drinking problem ( x ¯ $$ \overline{x} $$ = 27.8% vs. x ¯ $$ \overline{x} $$ = 18.8%). Partial correlations, controlling for maternal average drinks per drinking day (DDD) by trimester and maternal tobacco use, indicated a significant, negative association between paternal heavy/binge drinking (≥5) and child outcomes resulting in a significant reduction in child height, head circumference, and verbal IQ. Categorical analysis of combined levels of maternal and paternal drinking indicated a significant mean reduction in child height, head circumference, and verbal IQ centile, and a significant increase in total dysmorphology score, did not occur without maternal drinking. Combined paternal and maternal drinking pattern analysis also indicated that paternal drinking was not independently associated with child total dysmorphology scores or neurocognitive outcomes. Models of maternal and paternal drinking were significant, but main and significant effects on total dysmorphology and neurocognitive outcomes were via maternal alcohol consumption. Likewise, paternal alcohol consumption was not independently associated with an FASD diagnosis when controlling for prenatal maternal alcohol and tobacco use.Conclusions: Paternal alcohol consumption was associated with an independent, negative influence on child height, head circumference, and verbal IQ. Maternal drinking, when combined with heavy male drinking, was associated with more severe FASD outcomes.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
