Scoping review of the effects of antihistamines on physiological responses to alcohol among individuals with natural and induced alcohol flushing reactions.

IF 2.7 Q2 SUBSTANCE ABUSE
Tommy Gunawan, Sarah S Izabel, B Eric Turnquist, Nancy Diazgranados, Vijay A Ramchandani
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Abstract

Background: Individuals with a genetically driven impairment in acetaldehyde metabolism have acute alcohol sensitivity and experience a range of heightened physiological responses, including skin flushing after consuming alcohol. Some individuals consume histamine receptor antagonists (antihistamines) to block the skin flushing response. However, our knowledge of the effects of antihistamines on the physiological responses of alcohol is poor. The purpose of this scoping review was to evaluate the current evidence of the effects of antihistamines on the physiological effects of alcohol among individuals with acute alcohol sensitivity and identify gaps in this literature.

Methods: A scoping review was conducted to identify studies prior to March 2024 that administered alcohol and antihistamines to individuals with natural or induced alcohol sensitivity and examined the following physiological responses: skin flushing, heart rate, blood pressure, and skin temperature.

Results: Seven experimental studies were identified. Antihistamines showed some evidence in reducing alcohol-induced skin flushing, which was associated with a reduction in skin temperature. Antihistamines showed inconsistent effects on alcohol-associated changes in HR and BP.

Conclusions: Antihistamines may attenuate alcohol skin flushing in alcohol-sensitive individuals with mixed and inconclusive effects on other physiological responses. Current evidence is limited by small sample sizes, inconsistent findings, and a lack of acetaldehyde measurement. These limitations highlight the urgent need for rigorous studies to clarify the health risks of alcohol-antihistamine co-use and to inform harm reduction strategies for vulnerable populations. Understanding these interactions is vital for public health to inform targeted education and interventions.

综述了抗组胺药对酒精生理反应的影响,包括自然的和诱导的酒精脸红反应。
背景:基因驱动乙醛代谢损伤的个体具有急性酒精敏感性,并经历一系列增强的生理反应,包括饮酒后皮肤发红。有些人服用组胺受体拮抗剂(抗组胺药)来阻止皮肤潮红反应。然而,我们对抗组胺药对酒精生理反应的影响知之甚少。本综述的目的是评估抗组胺药对急性酒精敏感性个体酒精生理影响的现有证据,并确定文献中的空白。方法:对2024年3月之前的研究进行了范围综述,以确定对天然或诱导酒精敏感性个体给予酒精和抗组胺药的研究,并检查了以下生理反应:皮肤潮红、心率、血压和皮肤温度。结果:确定了7项实验研究。抗组胺药在减少酒精引起的皮肤潮红方面显示出一些证据,这与皮肤温度的降低有关。抗组胺药对酒精相关的HR和BP变化的影响不一致。结论:抗组胺药可能减轻酒精敏感个体的酒精皮肤潮红,但对其他生理反应的影响是混合的,不确定的。目前的证据受到样本量小、发现不一致和缺乏乙醛测量的限制。这些限制突出表明,迫切需要进行严格的研究,以澄清酒精与抗组胺药共同使用的健康风险,并为弱势群体提供减少危害的战略信息。了解这些相互作用对于公共卫生为有针对性的教育和干预提供信息至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
5.40
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