Early alcohol abstinence symptoms and the role of cumulative adversity.

IF 2.7 Q2 SUBSTANCE ABUSE
Helen C Fox, Jorge Alcina, Scott M Hyman, Verica Milivojevic, Rajita Sinha
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引用次数: 0

Abstract

Background: This study examined the course of early alcohol abstinence symptoms across multiple clinical domains (i.e., cravings, withdrawal, mood, and cardiovascular measures) in individuals undergoing inpatient alcohol treatment and assessed whether cumulative lifetime adversity influences the severity and trajectory of these symptoms.

Methods: Researchers tracked withdrawal symptoms, alcohol cravings, mood states, heart rate, and blood pressure in 34 inpatient participants at treatment admission and weekly for three to four consecutive weeks. The analysis employed two approaches: first, examining symptom presentation and progression over time in alcohol-dependent individuals using cumulative adversity as a moderating variable; second, comparing symptom patterns between alcohol-dependent participants with high versus low lifetime adversity against 38 control participants at each timepoint.

Results: Abstinence symptoms resolved by the third week of inpatient treatment across all participants. However, alcohol-dependent individuals with greater lifetime adversity exhibited significantly more severe symptom patterns compared to alcohol-dependent individuals with fewer adverse experiences. These differences persisted even when controlling for recent alcohol and tobacco use severity over the preceding 3 months.

Conclusions: Understanding the profile and progression of early abstinence symptoms, along with stress-related moderating factors, could inform more personalized care planning. Cumulative lifetime adversity may serve as a readily measurable correlate of early abstinence severity and may be valuable for predicting alcohol treatment outcomes. Addressing the effects of cumulative lifetime adversity may serve as a target for early intervention in patients with alcohol use disorder.

早期戒酒症状与逆境累积的作用。
背景:本研究考察了接受住院酒精治疗的个体在多个临床领域(即渴望、戒断、情绪和心血管测量)的早期戒酒症状的过程,并评估了累积终生逆境是否会影响这些症状的严重程度和发展轨迹。方法:研究人员追踪了34名住院患者的戒断症状、酒精渴望、情绪状态、心率和血压,这些患者在治疗入院时和每周连续三到四周。该分析采用了两种方法:首先,使用累积逆境作为调节变量,检查酒精依赖个体的症状表现和进展情况;其次,在每个时间点比较终身逆境高与低的酒精依赖参与者与38名对照参与者之间的症状模式。结果:所有参与者的戒断症状在住院治疗的第三周得到解决。然而,与不良经历较少的酒精依赖个体相比,终生逆境较大的酒精依赖个体表现出更严重的症状模式。即使在控制前3个月最近的酒精和烟草使用严重程度时,这些差异仍然存在。结论:了解早期戒断症状的概况和进展,以及与压力相关的调节因素,可以为更个性化的护理计划提供信息。累积的终生逆境可以作为早期戒酒严重程度的一种容易测量的相关性,并且可能对预测酒精治疗结果有价值。解决累积终生逆境的影响可能是酒精使用障碍患者早期干预的目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
5.40
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0.00%
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