Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Upregulation of E3 ligase UBR2 in acetaldehyde-treated C2C12 myotubes and its potential involvement in fast-twitch muscle atrophy in alcohol-fed rats.","authors":"Kaori Shintani-Ishida, Hiroshi Ikegaya","doi":"10.1111/acer.70102","DOIUrl":"https://doi.org/10.1111/acer.70102","url":null,"abstract":"<p><strong>Background: </strong>Chronic alcohol intake induces atrophy of type II (anaerobic, fast-twitch) muscle fibers in preference to type I (aerobic, slow-twitch) muscle fibers. However, the molecular mechanism underlying the preferential atrophy of type II muscle fibers remains unclear. The ubiquitin-proteasome system (UPS) mediates the degradation of myofibrillar proteins in skeletal muscle loss. This study investigated whether E3 ubiquitin ligases, including UBR2 and MuRF1, are involved in ethanol-induced type II muscle fiber-specific atrophy.</p><p><strong>Methods: </strong>In a chronic alcohol intake rat model, 4- to 5-week-old male Wistar rats were fed the Lieber-DeCarli liquid diet for 8 weeks. Muscle specimens were collected from the extensor digitorum longus (EDL) and soleus muscles of both legs. In an in vitro model, myotubes differentiated from murine C2C12 myoblasts were treated with culture medium containing 100 mM ethanol or 1 mM acetaldehyde for 6 h.</p><p><strong>Results: </strong>The muscle weight of the EDL seemed to be lesser in the ethanol group compared to the control group, and there was no difference in the muscle weight of the soleus between these groups. Cross-sectional area (CSA) of type IIA, IIB, and IIX muscle fibers in the EDL of ethanol-fed rats was smaller compared to the control rats, and CSA of type I muscle fibers in the soleus was larger in ethanol-fed rats. UBR2 protein levels seem to increase in the EDL but not in the soleus, whereas MuRF1 protein level remained unchanged in both muscles. C2C12 myotubes expressing MHC IIb, characteristics of type IIB muscle fibers, showed reduced myotube diameter after ethanol or acetaldehyde treatment. Acetaldehyde treatment increased UBR2 expression, but not MuRF1 expression, and enhanced ubiquitination. Knockdown of UBR2 using siRNA prevented acetaldehyde-induced myotube atrophy.</p><p><strong>Conclusion: </strong>This study demonstrated that the E3 ligase UBR2 may play a role in alcohol-induced type II muscle-preferential atrophy.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing subjective effects and intoxication on simultaneous alcohol and cannabis use occasions relative to alcohol- or cannabis-only occasions.","authors":"Ashley N Linden-Carmichael, Shou-Chun Chiang, Walter Dyer, Sandesh Bhandari, Stephanie T Lanza","doi":"10.1111/acer.70101","DOIUrl":"https://doi.org/10.1111/acer.70101","url":null,"abstract":"<p><strong>Background: </strong>Simultaneous use of alcohol and cannabis-or use of both substances so effects overlap-is common among college-attending young adults and can heighten one's likelihood of experiencing substance-related harms in daily life. Limited ecological momentary assessment and daily diary work have examined the role of subjective intoxication and subjective effects when engaging in simultaneous relative to alcohol- or cannabis-only use, and studies have yielded mixed results. As such, subjective experiences serve as important internal cues for decision making; this study aimed to examine the level of subjective intoxication and effects across simultaneous, alcohol-only, and cannabis-only occasions.</p><p><strong>Methods: </strong>Participants were 119 college students aged 18-25 who reported weekly simultaneous use at baseline. Participants enrolled in a 4-week ecological momentary assessment study with up to eight prompts per day collected on weekend days.</p><p><strong>Results: </strong>Multilevel models revealed that relative to alcohol- and cannabis-only days, simultaneous use days were not significantly associated with subjective alcohol or cannabis intoxication, respectively. Peak levels of subjective alcohol effects were, however, significantly stronger during simultaneous use occasions relative to alcohol-only use occasions. Subjective cannabis effects were not significantly different between simultaneous and cannabis-only use days.</p><p><strong>Conclusions: </strong>Study findings suggest that \"adding\" cannabis to an alcohol use occasion may bolster subjective effects such as feeling clumsy, confused, and having difficulty concentrating. Findings also highlight that subjective effects, rather than degree of impairment/intoxication, more strongly differentiates alcohol and simultaneous use occasions, and may serve as a useful momentary intervention target in future work.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risky relationships: Secondhand harms and health indicators associated with college students' relationships with heavy drinkers","authors":"Pamela J. Trangenstein,&nbsp;Erika M. Rosen,&nbsp;Christina C. Tam,&nbsp;Jih-Cheng Yeh,&nbsp;Thomas K. Greenfield,&nbsp;David H. Jernigan","doi":"10.1111/acer.70083","DOIUrl":"10.1111/acer.70083","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Heavy drinking is pervasive on college campuses, yet little is known about how heavy drinkers affect college students around them. People with versus without heavy drinkers in their lives often differ systematically, complicating such analyses. This study tested whether relationships with heavy drinkers were associated with alcohol-related harms to others (AHTOs) and related health indicators among college students after using propensity score weighting to account for demographic and behavioral differences between those with and without heavy drinkers in their lives.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Data were from a probability-based survey of 1901 US college students, recruited in November–December 2021 (16% response rate), 271 of whom had a heavy drinker in their life. There were two sets of outcomes: (1) AHTOs (i.e., harassment, physical, sexual) and (2) health indicators (i.e., frequent mental distress and service use because of someone else's drinking). Secondary models were stratified by the heavy drinker's relationship to the participant (i.e., intimate peer, other peer, and family member). To correct for multiple testing, <i>p</i>-values &lt; 0.002 were considered significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In double-robust propensity score-weighted regressions, relationships with a heavy drinker (vs. not) were associated with harassment (aOR = 3.89 [2.05, 7.38]) and sexual AHTOs (aOR = 2.98 [1.29, 6.88]). Students with a heavy drinker in their life (vs. not) had greater odds of frequent mental distress (aOR = 2.05 [1.28, 3.29]) and service use because of someone else's drinking (aOR = 7.39 [3.32, 16.47]). All relationship types were associated with harassment and service use because of someone else's drinking. Relationships with heavy drinking other peers and family members were associated with frequent mental distress.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Relationships with a heavy drinker are associated with college AHTOs and health indicators.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 7","pages":"1576-1586"},"PeriodicalIF":3.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"48th Annual RSA Scientific Meeting/ISBRA Congress: June 21–25, 2025, New Orleans, LA","authors":"","doi":"10.1111/acer.70062","DOIUrl":"https://doi.org/10.1111/acer.70062","url":null,"abstract":"<p>\u0000 \u0000 </p><p>\u0000 \u0000 </p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 S1","pages":"4-7"},"PeriodicalIF":3.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Abstracts","authors":"","doi":"10.1111/acer.70063","DOIUrl":"https://doi.org/10.1111/acer.70063","url":null,"abstract":"<p>*Abstract numbers do not correlate to poster number assigned for presentation at the Annual Meeting.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 S1","pages":"125-537"},"PeriodicalIF":3.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RSA & ISBRA 2025 Symposia & Workshops","authors":"","doi":"10.1111/acer.70061","DOIUrl":"https://doi.org/10.1111/acer.70061","url":null,"abstract":"<p>Abstract withdrawn</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 S1","pages":"8-124"},"PeriodicalIF":3.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Texas Research Society on Alcoholism—35th Annual Scientific Meeting","authors":"","doi":"10.1111/acer.70060","DOIUrl":"https://doi.org/10.1111/acer.70060","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 S1","pages":"565-570"},"PeriodicalIF":3.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Need for international consensus on diagnostic criteria for fetal alcohol spectrum disorders (FASD): Commentary on Myers et al., \"Comparing rates of agreement between different diagnostic criteria for fetal alcohol spectrum disorder: A systematic review\".","authors":"Elizabeth Jane Elliott","doi":"10.1111/acer.70095","DOIUrl":"https://doi.org/10.1111/acer.70095","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The reciprocal relationship between posttraumatic stress disorder symptoms and alcohol use in a large multisite longitudinal sample stratified by sex: A random-intercept cross-lagged panel model","authors":"Cecilia A. Hinojosa,&nbsp;Sanne J. H. van Rooij,&nbsp;Negar Fani,&nbsp;Robyn A. Ellis,&nbsp;Henri M. Garrison-Desany,&nbsp;Stacey L. House,&nbsp;Francesca L. Beaudoin,&nbsp;Xinming An,&nbsp;Thomas C. Neylan,&nbsp;Gari D. Clifford,&nbsp;Sarah D. Linnstaedt,&nbsp;Laura T. Germine,&nbsp;Scott L. Rauch,&nbsp;The AURORA Study Group,&nbsp;Karestan C. Koenen,&nbsp;Kerry J. Ressler,&nbsp;Samuel A. McLean,&nbsp;Jennifer S. Stevens","doi":"10.1111/acer.70092","DOIUrl":"10.1111/acer.70092","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) often co-occur. There is a lack of longitudinal studies measuring the naturalistic development of PTSD and alcohol use problems in individuals with recent trauma exposure. This study aimed to compare the temporal relationships between posttraumatic stress symptoms and alcohol use over 6 months following trauma exposure in males and females.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Large-scale longitudinal observational emergency department (ED)-based study of individuals with recent trauma exposure. Individuals with recent trauma exposure (<i>n</i> = 2942, 62% female) were recruited from 29 EDs across the United States within 72 h of trauma exposure from 2017 to 2021. PTSD symptoms, measured via the PTSD Checklist for the DSM-5, and alcohol use measured via the PhenX toolkit, were assessed at five time points: ED visit, 2 weeks, 8 weeks, 3 months, and 6 months following trauma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PTSD symptoms predicted lower future alcohol use between the pretrauma to two-week time points (<i>b</i> = −0.08, <i>p</i> = 0.01) and higher use between the 3- to 6-month time points (<i>b</i> = 0.06, <i>p</i> = 0.01). There were no time points in which alcohol use predicted future PTSD symptoms. When stratifying by sex, male participants showed reciprocal associations, with alcohol use early after trauma predicting PTSD symptoms between 2 and 8 weeks (<i>b</i> = 0.08, <i>p</i> = 0.01), while PTSD symptoms predicted alcohol use between the 3- to 6-month time points (<i>b</i> = 0.10, <i>p</i> = 0.01). Female participants showed a different reciprocal pattern, with pretrauma PTSD symptoms predicting lower alcohol use 2 weeks posttrauma (<i>b</i> = −0.08, <i>p</i> = 0.04), while alcohol use subsequently predicted greater PTSD symptoms from 8 weeks to 3 months (<i>b</i> = 0.04, <i>p</i> = 0.04); these findings did not survive Bonferroni correction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Males and females exhibit complex temporal development patterns of PTSD symptoms and alcohol use that align with the mutual maintenance hypothesis in males but the susceptibility hypothesis in females. These patterns are masked in analyses that do not stratify by sex.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 7","pages":"1504-1517"},"PeriodicalIF":3.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the responsivity of men's perceptions of sexual interest: The impact of sexual consent communications, acute intoxication, and past perpetration of sexual aggression","authors":"Lauren Smith,&nbsp;William H. George,&nbsp;Elizabeth C. Neilson","doi":"10.1111/acer.70093","DOIUrl":"10.1111/acer.70093","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Several distal and proximal processes have been implicated in sexual aggression (SA) perpetration, including sexual misperception, or the erroneous perception of a potential partner's sexual interest or consent, alcohol intoxication, and past perpetration. Little is known about how these predictors interact in the context of a sexual interaction. Thus, the present study aimed to investigate how men's perceptions of a woman's sexual interest changed over the course of a hypothetical sexual interaction and how their intoxication, past perpetration and the woman's consent cues influenced those perceptions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Single, male social drinkers aged 21–30 with a history of risky sexual behavior (<i>N</i> = 97) completed an alcohol administration paradigm in which they were randomly assigned to an alcohol condition (sober control vs. intoxicated [BrAC = 0.10%]). Participants read a hypothetical scenario in which a man and woman engaged in nonpenetrative sex and the woman expressed nonconsent nonverbally and verbally. At several points during the scenario, participants rated the woman's sexual interest. Participants also reported their past perpetration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Men's perceptions of the woman's sexual interest significantly decreased following verbal expressions of nonconsent. There were no significant differences between intoxicated and sober participants' ratings of the woman's sexual perception following verbal expressions of nonconsent. Men with a history of perpetration rated the woman's sexual interest following multiple verbal expressions of nonconsent as higher than nonperpetrators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Results suggest that intoxication does not necessarily impede men's ability to adjust their perceptions of a woman's sexual interest following verbal expressions of nonconsent.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 7","pages":"1614-1625"},"PeriodicalIF":3.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}