Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Hazardous alcohol use and cardiometabolic risk among firefighters.","authors":"Danielle E Levitt, Kealey J Wohlgemuth, Emilie F Burnham, Michael J Conner, J Jason Collier, Jacob A Mota","doi":"10.1111/acer.15517","DOIUrl":"https://doi.org/10.1111/acer.15517","url":null,"abstract":"<p><strong>Background: </strong>Alcohol misuse is prevalent among firefighters, and associated adverse cardiometabolic health consequences could negatively impact readiness for duty. Mental health conditions may confer additional risk. Therefore, we aimed to determine whether alcohol misuse increases cardiometabolic risk among firefighters and whether mental health conditions modify these relationships.</p><p><strong>Methods: </strong>Deidentified data from firefighters (N = 2405; 95.8% males, 38 ± 9 years, 29.6 ± 4.6 kg/m²) included demographics, Alcohol Use Disorders Identification Test (AUDIT) and AUDIT-C scores, mental health screening scores, anthropometrics, metabolic panel, and cardiorespiratory testing results. Differences in cardiometabolic parameters between firefighters with low AUDIT-C (<3 [females] or <4 [males]; no or low-risk alcohol use) or high AUDIT-C (≥3 [females] or ≥4 [males]; hazardous alcohol use) were determined and odds ratios for clinical risk factors were calculated. Posttraumatic stress disorder (PTSD), insomnia, depression, and anxiety were assessed as moderators.</p><p><strong>Results: </strong>Firefighters with high AUDIT-C had significantly (p < 0.05) higher total cholesterol (TC), high-density lipoprotein (HDL-C), and systolic blood pressure (SBP) and diastolic blood pressure (DBP) and lower hemoglobin A1C (HbA1c) than those with low AUDIT-C. In unadjusted and/or adjusted analyses, those with high AUDIT-C had increased risk for overweight/obesity, hypercholesterolemia, and prehypertension/hypertension, and decreased risk for low HDL and elevated HbA1c. There were inverse moderation effects by posttraumatic stress disorder (PTSD), depression, and anxiety on relationships between AUDIT-C score and BP. Insomnia (directly) and anxiety (inversely) moderated relationships between AUDIT-C score and circulating lipids.</p><p><strong>Conclusions: </strong>Firefighters with high AUDIT-C have differential cardiometabolic risk, with specific relationships altered by mental health status. Whether higher HDL and lower HbA1c with high AUDIT-C in firefighters is protective long-term remains to be explored. Overall, these results underscore the need for alcohol screening and intervention to maintain cardiometabolic health and long-term occupational readiness among firefighters.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary adenylate cyclase-activating polypeptide (PACAP)overexpression in the paraventricular nucleus of the thalamus alters motivated and affective behavior in female rats.","authors":"Brody A Carpenter, Breanne E Pirino, Malcolm C Jennings, Shanna B Samels, Krisha S Shah, Joya Maser, Medha Gupta, Jessica R Barson","doi":"10.1111/acer.15525","DOIUrl":"10.1111/acer.15525","url":null,"abstract":"<p><strong>Background: </strong>Pituitary adenylate cyclase-activating polypeptide (PACAP) has been found to be involved in a wide range of motivated and affective behaviors. While the PACAP-38 isoform is more densely expressed than PACAP-27 in most of the brain, PACAP-27 is more highly expressed in the rodent paraventricular nucleus of the thalamus (PVT), where females also have greater expression than males. Notably, the role of PACAP-27 expression in cells of the PVT has not been explored.</p><p><strong>Methods: </strong>Adult, female Long-Evans rats were injected in the PVT with an adeno-associated virus (AAV) to increase expression of PACAP or a control AAV. They were then investigated for subsequent ethanol drinking and preference; sucrose drinking and preference; or locomotor activity in a novel chamber, behavior in a light-dark box, behavior in a novelty suppression of feeding test, locomotor activity in a familiar activity chamber, and behavior in a forced swim test.</p><p><strong>Results: </strong>Injection with the PACAP AAV resulted in a specific increase in levels of PACAP-27. Rats injected with the PACAP AAV demonstrated reduced drinking and preference for ethanol under the intermittent-access procedure compared to those injected with the control AAV. In contrast, rats injected with the PACAP AAV showed no significant difference in drinking or preference for sucrose, or in any affective behavior tested, except that they spent less time swimming in the forced swim test.</p><p><strong>Conclusions: </strong>In light of the low overall level of expression of PACAP-27 in the brain, the ability of PACAP-27 in the PVT to control ethanol drinking, with minimal effects on other motivated or affective behaviors, supports the idea that compounds related to PACAP-27 should be investigated as potential therapeutics for the treatment of alcohol use disorder.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Societal spirits in the silver streak: Unraveling complexity in drinking habits of the mature adult population","authors":"Maarten W. J. van den Ende,&nbsp;René Freichel,&nbsp;Han L. J. van der Maas,&nbsp;Reinout W. Wiers,&nbsp;Sacha Epskamp","doi":"10.1111/acer.15486","DOIUrl":"10.1111/acer.15486","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The complex interactions between an individual's drinking behavior and their social environment is crucial but understudied, particularly in mature adult populations. Our aim is to unravel these complexities by investigating how personal drinking patterns are related to those of one's social environment over time, and what the interplay is with personal factors such as occupational prestige and smoking behavior.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>The present study adopts an innovative graphical autoregressive (GVAR) panel network modeling approach to investigate the dynamics between personal drinking habits and social environmental factors, utilizing a comprehensive longitudinal dataset from the Framingham Heart Study with a large sample of predominantly mature adults (<i>N</i> = 1719–5718) connected within a social network. We explored both temporal and contemporaneous associations between individuals' drinking habits (self-reported), smoking behavior (self-reported), perceived job prestige (Treiman prestige score), and the drinking behaviors of their social environment. The latter consists of the proportion of abstaining, moderate drinking, and heavy drinking social connections of each subject.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our findings reveal significant associations between participants' behavior and that of their peers, with reciprocal interactions, substantiating the importance of the influence of one's social network for mature individuals. We found dynamic, reciprocal associations between an individual's drinking behavior and that of their peers, with periods of increased or decreased drinking correlating with increased connections to heavy drinkers or abstainers, respectively. In addition, when individuals drink more than usual, they also tend to consume more cigarettes, and vice versa.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The reciprocal feedback loops identified between an individual's drinking behavior and their social environment highlight the crucial role of social influences in shaping drinking behavior, including among older people. This emphasizes the need to consider social elements in the development of future theories, models, and interventions aimed at addressing problematic alcohol consumption in this vulnerable population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"217-225"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining social attention as a predictor of problem drinking behavior: A longitudinal study using eye-tracking","authors":"Jiaxu Han,&nbsp;Catharine E. Fairbairn,&nbsp;Walter James Venerable III,&nbsp;Sarah Brown-Schmidt,&nbsp;Talia Ariss","doi":"10.1111/acer.15490","DOIUrl":"10.1111/acer.15490","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Researchers have long been interested in identifying objective markers for problem drinking susceptibility informed by the environments in which individuals drink. However, little is known of objective cognitive-behavioral indices relevant to the social contexts in which alcohol is typically consumed. Combining group-based alcohol administration, eye-tracking technology, and longitudinal follow-up over a 2-year span, the current study examined the role of social attention in predicting patterns of problem drinking over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Young heavy drinkers (<i>N</i> = 246) were randomly assigned to consume either an alcoholic (target BAC 0.08%) or a control beverage in dyads comprising friends or strangers. Dyads completed a virtual video call in which half of the screen comprised a view of themselves (“self-view”) and half a view of their interaction partner (“other-view”). Participants' gaze behaviors, operationalized as the proportion of time spent looking at “self-view” and “other-view,” were tracked throughout the call. Problem drinking was assessed at the time of the laboratory visit and then every year subsequent for 2 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant interactions emerged between beverage condition and social attention in predicting binge drinking days. In cross-sectional analyses, among participants assigned to the control (but not alcohol) group, heightened self-focused attention was linked with increased binge days at baseline, <i>B</i> = 0.013, <i>Exp(B)</i> = 1.013, 95% CI <i>=</i> [0.004, 0.022], <i>p</i> = 0.005. In contrast, longitudinal models indicated that heightened self-focused attention among control participants while interacting with friends was linked with a more pronounced decline in binge drinking over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The relationship between social attention and problem drinking is complex and evolves over time. While dispositional self-consciousness may act as a risk factor at the cross-sectional level, it appears to serve a potentially protective function as participants mature into young adulthood. More broadly, results highlight potential utility for objective markers of self-consciousness in the understanding of problem drinking etiology.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"153-164"},"PeriodicalIF":3.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beliefs and attitudes about men's alcohol-related sexual harassment and aggression (BAMASHA): Development and initial validation of a new scale","authors":"Katarina L. Huellemann,&nbsp;Kathryn Graham,&nbsp;Sharon Bernards,&nbsp;Paul Tremblay,&nbsp;Antonia Abbey,&nbsp;Charlene Senn,&nbsp;Victoria Banyard,&nbsp;Sarah McMahon,&nbsp;Tara M. Dumas,&nbsp;Samantha Wells","doi":"10.1111/acer.15477","DOIUrl":"10.1111/acer.15477","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Men's perpetration of sexual violence (SV) toward women in drinking venues is a pervasive yet understudied phenomenon with significant downstream consequences for women. Although men's negative attitudes and beliefs toward women play an important role in SV, current attitude measures are limited in that they do not focus on SV specific to drinking contexts, thereby precluding understandings of SV in this context. As such, we developed and evaluated a measure of beliefs and attitudes about men's alcohol-related sexual harassment and aggression (BAMASHA) toward women in drinking venues to better understand this ubiquitous problem.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Young heterosexual men (<i>N</i> = 330, <i>M</i>_age = 22.66, <i>SD</i> = 2.09) completed an online survey that included 82 BAMASHA items developed to assess eight theoretical dimensions/sub-dimensions derived from past research. The survey also measured sexual aggression perpetration in drinking venues and well-established correlates of SV including drinking patterns, rape myth acceptance, hostility toward women, stereotypes about drinking women, and alcohol expectancies regarding sexual behavior.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Item analysis resulted in a 24-item inventory with exploratory and confirmatory factor analyses suggesting a unidimensional factor structure. The resultant measure and its 12-item short form also explained sexual aggression perpetration toward women in drinking venues when controlling for associated constructs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Findings underscore the unique contributions of the BAMASHA for sexual aggression perpetration and its utility in the context of drinking venues compared to measures of attitudes and beliefs toward SV more generally.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"128-141"},"PeriodicalIF":3.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"US mortality trends from alcohol-associated hepatitis by sex, age, race, and ethnicity, 1999-2020.","authors":"Bubu A Banini, Sanjaya Chauhan, Ayesha Amatya, Farzaneh Dashti, Khaled Zahrawi, Frhaan Zahrawi, Wajahat Z Mehal, Sherry A McKee","doi":"10.1111/acer.15515","DOIUrl":"https://doi.org/10.1111/acer.15515","url":null,"abstract":"<p><strong>Background: </strong>Alcohol-associated hepatitis (AH) is a subtype of alcohol-associated liver disease (ALD) resulting in severe acute liver inflammation. This study aims to examine longitudinal trends in mortality from AH in the United States (US) from 1999 to 2020, stratifying the data by sex, age, and racial/ethnic groups.</p><p><strong>Methods: </strong>We performed a cross-sectional study using data from the US Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (WONDER) to determine annual AH-related mortality rates (MR) in adults ≥21 years between 1999 and 2020. Data were stratified by sex, race, and 10-year age groups. Considering 1999 as baseline, mortality rate ratio (MRR) was calculated to characterize the MR in a particular year compared to baseline. Joinpoint regression analysis was conducted to characterize year-wise log-linear time calendar trends in MR.</p><p><strong>Results: </strong>From 1999 through 2020, AH-related deaths doubled from 0.5 per 100,000 (95% CI 0.5 to 0.6) to 1.1 per 100,000 (95% CI 1.1 to 1.2). While mortality rates for males doubled from 0.8 per 100,000 (95% CI 0.7 to 0.8) to 1.5 per 100,000 (95% CI 1.4 to 1.6), mortality rates for females almost tripled from 0.3 per 100,000 (9%% CI 0.3 to 0.4) to 0.8 per 100,000 (95% CI 0.7 to 0.8). The steepest increase in AH-related deaths from 1999 to 2020 were among American Indians/Alaska Natives and young adults 25-34 years, and particularly young adult females.</p><p><strong>Conclusions: </strong>Over the past two decades, overall AH-related mortality in the US has doubled. The steepest increase in AH-related mortality was noted among American Indians/Alaska Natives and young adults, particularly young adult females. Education and prevention efforts should target these high-risk populations, and studies aimed at elucidating biological and sociodemographic factors resulting in the differential rise in mortality are warranted.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Still rethinking the J-shaped curve: A commentary on Kember et al., 2024.","authors":"Alex P Miller","doi":"10.1111/acer.15523","DOIUrl":"https://doi.org/10.1111/acer.15523","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bereavement, prolonged grief, and the prevention of alcohol misuse.","authors":"Jeremy W Luk","doi":"10.1111/acer.15524","DOIUrl":"https://doi.org/10.1111/acer.15524","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Control of precision grip in children with heavy prenatal alcohol exposure.","authors":"Roger W Simmons, Jennifer D Thomas, Tanya T Nguyen, Sarah N Mattson, Edward P Riley","doi":"10.1111/acer.15504","DOIUrl":"10.1111/acer.15504","url":null,"abstract":"<p><strong>Background: </strong>Fine motor skill deficits have been reported for children with histories of prenatal alcohol exposure, but little is known whether impaired motor skill extends to the regulation of precision grip control.</p><p><strong>Methods: </strong>Children with (n = 15) and without (n = 17) histories of heavy prenatal alcohol exposure used their dominant hand to grasp, lift, and hold in space a small-instrumented object with a mass of 19 g. Object mass was also experimentally increased by separately adding two aluminum cubes with mass of 200 and 400 g. Participants completed a block of eight trials for each object mass with the last six trials in each trial block being statistically analyzed. Selected temporal and kinetic parameters of grip force (GF) and load force (LF) were examined to quantitatively index precision grip performance of the two groups.</p><p><strong>Results: </strong>Compared to typically developing peers, children with prenatal alcohol exposure used excessive and more variable LF and greater GF to lift each object mass, with more finger GF than thumb GF being applied to the apparatus. The GF/LF ratio for the clinical group was greater when lifting the smallest mass load. When holding the object in space, children with prenatal alcohol exposure produced greater GF for the smallest mass load, again with more GF being applied via the finger compared to the thumb.</p><p><strong>Conclusions: </strong>Children with heavy prenatal alcohol exposure demonstrate force deficits when using precision grip to manipulate an object with three different masses. Chronic irregular precision grip could manifest as a fine motor skill developmental delay that may negatively impact completion of functional activities of daily living requiring grasping an object with the index finger and thumb.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing initial/early aversion-resistant drinking across male and female alcohol-preferring and non-preferring rats.","authors":"Kari M Haines, Nicholle E Smith, Cristine L Czachowski","doi":"10.1111/acer.15518","DOIUrl":"https://doi.org/10.1111/acer.15518","url":null,"abstract":"<p><strong>Background: </strong>One trait of alcohol use disorder (AUD) is continuing to drink despite negative consequences. The current study investigated initial/early aversion-resistant drinking (ARD) across selectively bred alcohol-preferring lines to assess aversion resistance with minimal ethanol history and subsequent ethanol-seeking and drinking profiles. Additionally, ARD was assessed in alcohol-preferring and non-preferring rats using a sucrose reinforcer to determine if ARD may be a genetic risk factor for AUD.</p><p><strong>Methods: </strong>Male and female alcohol-preferring rats were given four concentrations of quinine (0.03, 0.10, 0.30, and 1.00 g/L-in random order) in an ethanol solution in the homecage for 30 min daily across 12 days. Seeking and drinking were then assessed in the operant chambers. Additional groups of alcohol-preferring and non-preferring rats were given access to the same concentrations of quinine-adulterated sucrose using the same daily, random-order presentation.</p><p><strong>Results: </strong>In ethanol, all preferring lines performed similarly, showing resistance to quinine at the lowest concentration. In the homecage, high-alcohol-drinking (HAD)1 rats drank high levels of ethanol similar to alcohol-preferring (P) rats, whereas in an operant task were more similar to the HAD2 rats. In sucrose, P and HAD2 rats were shown to be aversion resistant at low concentrations of quinine compared to baseline. Overall, the non-preferring lines all demonstrated sensitivity to quinine-adulterated sucrose.</p><p><strong>Conclusions: </strong>This study demonstrates alcohol-preferring lines show similar ARD when ethanol is the reinforcer. Regarding motivated responding, P rats show high-seeking and drinking behaviors as previously observed. In the homecage, HAD1 rats drink similarly to P rats indicating that different conditions (i.e., free vs. operant access) influence drinking behaviors between these lines. Importantly, in a sucrose reinforcer, alcohol-preferring rats are more aversion-resistant than non-preferring lines, while non-preferring lines show high sensitivity to aversion, suggesting an overall tendency to demonstrate a low level of compulsive behavior.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}